JP2009533483A - ２−メチレン−１α，２５−ジヒドロキシ−１８，１９，２１−トリノルビタミンＤ３およびその使用 - Google Patents
２−メチレン−１α，２５−ジヒドロキシ−１８，１９，２１−トリノルビタミンＤ３およびその使用 Download PDFInfo
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- JP2009533483A JP2009533483A JP2009508549A JP2009508549A JP2009533483A JP 2009533483 A JP2009533483 A JP 2009533483A JP 2009508549 A JP2009508549 A JP 2009508549A JP 2009508549 A JP2009508549 A JP 2009508549A JP 2009533483 A JP2009533483 A JP 2009533483A
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Landscapes
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| US74438506P | 2006-04-06 | 2006-04-06 | |
| PCT/IB2007/003971 WO2008125901A2 (en) | 2006-04-06 | 2007-04-06 | 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin d3 and uses thereof |
Publications (2)
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| JP2009533483A true JP2009533483A (ja) | 2009-09-17 |
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| JP2009532460A (ja) * | 2006-04-06 | 2009-09-10 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−置換−１α，２５−ジヒドロキシ−１９，２６，２７−トリノルビタミンＤ類縁体およびその使用 |
| US20110237557A1 (en) * | 2010-03-23 | 2011-09-29 | Deluca Hector F | Diastereomers of 2-methylene-19-nor-22-methyl-1alpha,25-dihydroxyvitamin d3 |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| US8604009B2 (en) * | 2010-03-23 | 2013-12-10 | Wisconsin Alumni Research Foundation | (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-hydroxyvitamin D3 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2005523906A (ja) * | 2002-02-18 | 2005-08-11 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | １α−ヒドロキシ−２−メチレン−１９−ノル−プレグナカルシフェロール及びその使用 |
| WO2005082456A1 (en) * | 2004-02-19 | 2005-09-09 | Wisconsin Alumni Research Foundation | USE OF 2-METHYLENE-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 FOR THE PROPHYLAXIS OF BONE DISEASES |
| WO2005102995A1 (en) * | 2004-04-09 | 2005-11-03 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin d compounds |
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| US4188345A (en) | 1978-07-26 | 1980-02-12 | Wisconsin Alumni Research Foundation | Fluorovitamin D compounds and processes for their preparation |
| US4411833A (en) | 1982-05-26 | 1983-10-25 | Wisconsin Alumni Research Foundation | Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol |
| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| US4970203A (en) | 1988-12-09 | 1990-11-13 | Deluca Hector F | Method for improving reproductive functions in mammals |
| US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| JP2898882B2 (ja) | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | ２−位に置換基を有する１９−ノル−ビタミンｄ３ 化合物 |
| US5880114A (en) | 1993-06-16 | 1999-03-09 | Wisconsin Alumni Research Foundation | Treatment of immune deficiency with vitamin D compounds |
| US6291444B1 (en) | 1993-06-16 | 2001-09-18 | Wisconsin Alumni Research Foundation | Treatment of t-cell immunodeficiencies with vitamin D compounds |
| US5552392A (en) | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| US5825133A (en) * | 1996-09-25 | 1998-10-20 | Rockwell International | Resonant inverter for hot cathode fluorescent lamps |
| US6306844B1 (en) | 1997-03-17 | 2001-10-23 | Wisconsin Alumni Research Foundation | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| US5843928A (en) | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6392071B1 (en) | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6806262B2 (en) | 2000-05-31 | 2004-10-19 | Wisconsin Alumni Research Foundation | 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds |
| US6382071B1 (en) | 2000-08-07 | 2002-05-07 | Gilbert A. Bertani | Bola capturing apparatus |
| AU7544501A (en) | 2000-09-08 | 2002-03-22 | Wisconsin Alumni Res Found | 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
| US20030018017A1 (en) | 2001-01-25 | 2003-01-23 | Deluca Hector F. | Method of treatment of type I diabetes |
| US20040214803A1 (en) | 2001-05-22 | 2004-10-28 | Luciano Adorini | Use of vitamin d3 analogue for the treatment of autoimmune diabetes |
| US6627622B2 (en) | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6846811B2 (en) | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
| GB0305332D0 (en) | 2003-03-10 | 2003-04-09 | Leuven K U Res & Dev | Biological evaluation of novel vitamin D analogues |
| NZ542674A (en) | 2003-04-10 | 2009-03-31 | Wisconsin Alumni Res Found | 2-Propylidene-19-nor-vitamin D compounds |
| US20050009792A1 (en) | 2003-07-08 | 2005-01-13 | Deluca Hector F. | (20S)-1alpha-hydroxy-2-methylene-19-nor-vitamin D3 and its uses |
| WO2005051396A2 (en) | 2003-11-25 | 2005-06-09 | Deltanoid Pharmaceuticals, Inc. | Methods for reducing body fat using vitamin d compounds |
| WO2005051323A2 (en) | 2003-11-25 | 2005-06-09 | Wisconsin Alumni Research Foundation | Vitamin d analogs for obesity prevention and treatment |
| WO2006057884A2 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2α-METHYL AND 2ß-METHYL ANALOGS OF 19,26,27-TRINOR-(20S)-1α-HYDROXYVITAMIN D3 AND THEIR USES |
| US7528122B2 (en) | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| US7803789B2 (en) | 2006-02-02 | 2010-09-28 | Wisconsin Alumni Research Foundation | Vitamin D analog—RAK, methods and uses thereof |
| NZ570814A (en) | 2006-04-06 | 2011-11-25 | Wisconsin Alumni Res Found | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
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- 2007-04-06 JP JP2009508549A patent/JP2009533483A/ja not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005523906A (ja) * | 2002-02-18 | 2005-08-11 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | １α−ヒドロキシ−２−メチレン−１９−ノル−プレグナカルシフェロール及びその使用 |
| WO2005082456A1 (en) * | 2004-02-19 | 2005-09-09 | Wisconsin Alumni Research Foundation | USE OF 2-METHYLENE-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 FOR THE PROPHYLAXIS OF BONE DISEASES |
| WO2005102995A1 (en) * | 2004-04-09 | 2005-11-03 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin d compounds |
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| WO2008125901A2 (en) | 2008-10-23 |
| US7704981B2 (en) | 2010-04-27 |
| WO2008125901A3 (en) | 2008-12-04 |
| WO2008125901A8 (en) | 2009-07-23 |
| AU2007349772A1 (en) | 2008-10-23 |
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| CA2639585A1 (en) | 2007-10-06 |
| EP2021321B1 (en) | 2012-06-20 |
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| EP2021321A2 (en) | 2009-02-11 |
| NZ571773A (en) | 2011-11-25 |
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