JP2009269855A5 - - Google Patents

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JP2009269855A5
JP2009269855A5 JP2008121573A JP2008121573A JP2009269855A5 JP 2009269855 A5 JP2009269855 A5 JP 2009269855A5 JP 2008121573 A JP2008121573 A JP 2008121573A JP 2008121573 A JP2008121573 A JP 2008121573A JP 2009269855 A5 JP2009269855 A5 JP 2009269855A5
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paramagnetic metal
polyamidoamine dendron
dendron lipid
metal
liposome
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JP2008121573A
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JP5397976B2 (en
JP2009269855A (en
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Claims (8)

ポリアミドアミンデンドロン脂質中の１以上の遊離アミノ基と、常磁性金属とがリンカーを介して結合してなる常磁性金属含有ポリアミドアミンデンドロン脂質。   A paramagnetic metal-containing polyamidoamine dendron lipid obtained by binding one or more free amino groups in a polyamidoamine dendron lipid and a paramagnetic metal via a linker. 常磁性金属が、ガドリニウムである請求項１に記載の常磁性金属含有ポリアミドアミンデンドロン脂質。   The paramagnetic metal-containing polyamidoamine dendron lipid according to claim 1, wherein the paramagnetic metal is gadolinium. 常磁性金属がキレート化合物の形態である請求項１又は２に記載の常磁性金属含有ポリアミドアミンデンドロン脂質。 The paramagnetic metal-containing polyamidoamine dendron lipid according to claim 1 or 2, wherein the paramagnetic metal is in the form of a chelate compound. 前記遊離アミノ基が、下記式由来のアミノ基である請求項１〜３のいずれか１項に記載の常磁性金属含有ポリアミドアミンデンドロン脂質：
ＤＬ−Ｇ２：Ｒ1Ｒ2ＮＸ（Ｘ（ＸＨ2）2）2
ＤＬ−Ｇ３：Ｒ1Ｒ2ＮＸ（Ｘ（Ｘ（ＸＨ2）2）2）2
ＤＬ−Ｇ４：Ｒ1Ｒ2ＮＸ（Ｘ（Ｘ（Ｘ（ＸＨ2）2）2）2）2
ＤＬ−Ｇ５：Ｒ1Ｒ2ＮＸ（Ｘ（Ｘ（Ｘ（Ｘ（ＸＨ2）2）2）2）2）2
ＤＬ−Ｇ６：Ｒ1Ｒ2ＮＸ（Ｘ（Ｘ（Ｘ（Ｘ（Ｘ（ＸＨ2）2）2）2）2）2）2
ＤＬ−Ｇ７：Ｒ1Ｒ2ＮＸ（Ｘ（Ｘ（Ｘ（Ｘ（Ｘ（Ｘ（ＸＨ2）2）2）2）2）2）2）2又は
ＤＬ−Ｇ８：Ｒ1Ｒ2ＮＸ（Ｘ（Ｘ（Ｘ（Ｘ（Ｘ（Ｘ（Ｘ（ＸＨ2）2）2）2）2）2）2）2）2
（式中、Ｒ1及びＲ2は同一又は異なって、アルキル基、アルコキシ基、アリール基又はアラルキル基を表し、Ｘは、−ＣＨ2ＣＨ2ＣＯＮＨＣＨ2ＣＨ2Ｎ＜を表す）。 The paraamino metal-containing polyamidoamine dendron lipid according to any one of claims 1 to 3, wherein the free amino group is an amino group derived from the following formula:
DL-G2: R 1 R 2 NX (X (XH 2 ) 2 ) 2
DL-G3: R 1 R 2 NX (X (X (XH 2 ) 2 ) 2 ) 2
DL-G4: R 1 R 2 NX (X (X (X (XH 2 ) 2 ) 2 ) 2 ) 2
DL-G5: R 1 R 2 NX (X (X (X (X (XH 2 ) 2 ) 2 ) 2 ) 2 ) 2
DL-G6: R 1 R 2 NX (X (X (X (X (X (XH 2) 2) 2) 2) 2) 2) 2
DL-G7: R 1 R 2 NX (X (X (X (X (X (X (XH 2 ) 2 ) 2 ) 2 ) 2 ) 2 ) 2 ) 2 ) 2 or DL-G8: R 1 R 2 NX (X (X (X (X (X (X (X (XH 2 ) 2 ) 2 ) 2 ) 2 ) 2 ) 2 ) 2 ) 2
(In the formula, R 1 and R 2 are the same or different and each represents an alkyl group, an alkoxy group, an aryl group or an aralkyl group, and X represents —CH 2 CH 2 CONHCH 2 CH 2 N <). 請求項１〜４のいずれか１項に記載の常磁性金属含有ポリアミドアミンデンドロン脂質を含む常磁性金属含有リポソーム。   Paramagnetic metal-containing liposome comprising the paramagnetic metal-containing polyamidoamine dendron lipid according to any one of claims 1 to 4. リポソーム膜が、ホスファチジルコリン及びホスファチジルセリンから選択される脂質で構成される請求項５に記載の常磁性金属含有リポソーム。   The paramagnetic metal-containing liposome according to claim 5, wherein the liposome membrane is composed of a lipid selected from phosphatidylcholine and phosphatidylserine. 請求項１〜４のいずれか１項に記載の常磁性金属含有ポリアミドアミンデンドロン脂質、又は請求項５又は６に記載の常磁性金属含有リポソームと、医薬的に許容される担体とを含むことを特徴とする磁気共鳴イメージング（ＭＲＩ）用の造影剤。   A paramagnetic metal-containing polyamidoamine dendron lipid according to any one of claims 1 to 4, or a paramagnetic metal-containing liposome according to claim 5 or 6, and a pharmaceutically acceptable carrier. A contrast agent for magnetic resonance imaging (MRI). 腫瘍部位を検出するための請求項７に記載の造影剤。   The contrast agent according to claim 7 for detecting a tumor site.
JP2008121573A 2008-05-07 2008-05-07 Paramagnetic metal-containing polyamidoamine dendron lipids Active JP5397976B2 (en)

Priority Applications (1)

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JP2008121573A JP5397976B2 (en) 2008-05-07 2008-05-07 Paramagnetic metal-containing polyamidoamine dendron lipids

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JP2009269855A JP2009269855A (en) 2009-11-19
JP2009269855A5 true JP2009269855A5 (en) 2011-06-23
JP5397976B2 JP5397976B2 (en) 2014-01-22

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* Cited by examiner, † Cited by third party
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CN103755923B (en) * 2013-12-26 2016-06-01 江苏苏博特新材料股份有限公司 A kind of low temperature curing type aliphatic amide epoxy polyamine resin curing agent and its preparation method
CN104558529B (en) * 2014-12-26 2017-10-10 江苏苏博特新材料股份有限公司 A kind of preparation method of acid amide type self-emulsifying aqueous epoxy resin curing agent
JP7220472B2 (en) * 2017-03-06 2023-02-10 国立大学法人 筑波大学 Liposomes, anticancer agents, and cancer treatment kits
WO2023240135A2 (en) 2022-06-07 2023-12-14 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates

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NL194579C (en) * 1983-01-21 2002-08-05 Schering Ag Diagnostic.
JP4305615B2 (en) * 2002-11-08 2009-07-29 公立大学法人大阪府立大学 Gene transfer agent composition comprising polyamidoamine dendron
JP2008510829A (en) * 2004-08-25 2008-04-10 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Compositions based on dendrimers and their use

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