JP2009264815A - Osmotic pressure analyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an osmotic pressure analyzer capable of shortening the time until a sample liquid is brought to a supercooled state by utilizing the standby time of the container, which waits for measurement and analysis, of a plurality of containers held by a holder. <P>SOLUTION: The osmotic pressure analyzer is equipped with: the containers 2 for housing the sample liquid; a cooling tank 7 which has a cooling means 8 and houses an antifreezing solution; and a moving means 4 for moving each of the containers 2 along with a thermistor 5, which is inserted in the container 2 to detect the temperature of the sample liquid, to introduce them into the cooling tank 7. In the analyzer, the temperature of the sample liquid is detected by the thermistor 5 when the freezing stimulation due to vibration is applied to the sample liquid after being supercooled to convert the supercooled sample liquid into a solid-liquid coexisting state to measure the solidification temperature (osmotic pressure) of the sample liquid. The osmotic pressure analyzer further includes a precooling means 17 for cooling the container 2 held to the holder 3. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention measures the coagulation temperature of the sample liquid by supercooling the sample liquid and then measuring the solidification temperature of the sample liquid by detecting the temperature when the solid and liquid are converted into a coexisting state by applying freezing stimulation by vibration. The present invention relates to an osmotic pressure analyzer for analyzing pressure.

  In general, a dialysate used in dialysis treatment is collected as a sample solution (sample solution) before use, and its osmotic pressure is analyzed by an osmotic pressure analyzer, which is used as an index. Such a conventional osmotic pressure analyzer is a thermistor and a vibrating needle that can be inserted into a container containing the collected dialysate as a sample solution, a cooling tank containing an antifreeze solution, the thermistor and the vibrating needle as a sample solution in the container. And moving means for moving into the cooling liquid while immersed.

  Specifically, after the sample liquid is supercooled (in a state where it does not freeze even if it is further cooled beyond the solidification temperature), freezing stimulation is applied by vibration with a vibrating needle and the solid and liquid coexist (solid liquid The coagulation temperature of the sample solution is measured by detecting the temperature at that time by temperature detection means such as a thermistor.

  However, the higher the osmotic pressure of the sample solution, the lower the coagulation temperature, and the lower the osmotic pressure, the higher the coagulation temperature. Therefore, the osmotic pressure can be analyzed by measuring the coagulation temperature as described above. Using this measured osmotic pressure as an index, it is possible to determine whether or not the dialysate is generally desired. In addition, since this prior art does not relate to the literature known invention, there is no prior art document information to be described.

  However, the conventional osmotic pressure analyzer has a problem in that it takes a relatively long time to move the container into the cooling tank to cool it and bring the sample liquid into a supercooled state. However, a holder that can hold a plurality of containers is provided so that each of the containers contains a sample solution, and the containers to be measured are sequentially moved into the cooling tank to measure the solidification temperature of the sample solution and the osmotic pressure. Although an osmotic pressure analyzer that automatically performs analysis of a sample has been proposed, the present applicant examines whether a waiting time of a plurality of containers held by a holder that is waiting for measurement / analysis can be used. It came to.

  The present invention has been made in view of such circumstances, and makes a sample liquid supercooled by using a waiting time of a plurality of containers held by a holder waiting for measurement / analysis. An object of the present invention is to provide an osmotic pressure analyzer capable of shortening the time until the time.

  The invention according to claim 1 is a cooling tank in which a container capable of storing a predetermined amount of sample liquid, a holder for holding a plurality of containers, an antifreeze liquid, and a cooling means for cooling the antifreeze liquid are provided. The temperature detection means capable of detecting the temperature of the sample liquid is moved so that it can be inserted into a predetermined one of the plurality of containers held by the holder, and the container can be moved together with the temperature detection means. And a moving means that can move the container through which the temperature detecting means is inserted into the cooling tank, and after the sample liquid in the container is supercooled, a solid is formed by applying freezing stimulation by vibration. In the osmotic pressure analyzer for analyzing the osmotic pressure by measuring the solidification temperature of the sample liquid by detecting the temperature when the temperature and the liquid are converted into a coexisting state, the temperature detection means holds the holder. The Characterized by comprising a pre-cooling means for cooling the vessel.

  According to a second aspect of the present invention, in the osmotic pressure analyzer according to the first aspect of the present invention, the osmotic pressure analyzer includes a bat that is made of a metal member having excellent heat conductivity and supports the lower surface of the container held by the holder, and the precool The means is characterized in that the container can be cooled by cooling the bat.

  According to a third aspect of the present invention, in the osmotic pressure analyzer according to the second aspect, the bat has a concave shape that follows the lower surface of the container held by the holder, and the concave shape of the holder The lower surface is supported.

  The invention according to claim 4 is the osmotic pressure analyzer according to any one of claims 1 to 3, further comprising a vibrating means that is inserted into the container and imparts vibration to the sample liquid. Is moved by the moving means together with the temperature detecting means to reach into the sample liquid.

  According to the invention of claim 1, since the pre-cooling means for cooling the container held by the holder is provided, the waiting time of the one waiting for measurement / analysis among the plurality of containers held by the holder is reduced. By using it, the time until the sample solution is brought into a supercooled state can be shortened.

  According to the second aspect of the present invention, the bat is provided to support the lower surface of the container made of a metal member having excellent heat conductivity and held by the holder, and the precooling means cools the container by cooling the bat. Since it was comprised so that it can do, the container in standby can be cooled beforehand with an efficient and simple structure.

  According to the invention of claim 3, the bat has a concave shape that follows the lower surface of the container held by the holder, and the lower surface of the holder is supported by the concave shape. The container can be cooled.

  According to the fourth aspect of the present invention, there is provided a vibrating means that is inserted into the container and imparts vibration to the sample liquid, and the vibrating means is moved by the moving means together with the temperature detecting means to reach the sample liquid. Therefore, the vibrating means and the temperature detecting means can be simultaneously immersed in the sample solution by the moving means.

Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The osmotic pressure analyzer according to the present embodiment detects the temperature of the sample liquid by supercooling the sample liquid and then detecting the temperature when the solid and liquid are converted into a coexisting state by applying freezing stimulation by vibration. The osmotic pressure is analyzed by measuring the coagulation temperature, and a dialysis solution is used as a sample solution. That is, by analyzing the osmotic pressure of the dialysate and using the measured value as an index, it is possible to determine whether or not the dialysate to be used in dialysis treatment is generally desired.

  As shown in FIGS. 1 to 5, the osmotic pressure analyzer includes a main body 1 on which a screen 18 with a touch key and an operation means 19 are formed, and a holder 3 that holds six containers 2 and one wiping container 11. And the cooling tank 7 and the moving means 4. The main body 1 constitutes a casing of the present osmotic pressure analyzer. A bat 10 containing the holder 3 is formed on the upper surface, and a screen 18 with touch keys and an operation means 19 are formed on the front surface.

  The container 2 can accommodate a predetermined amount of sample solution (dialysis solution in the present embodiment) inside, and is made of a transparent member having an open top and an arcuate bottom. The container 2 does not necessarily need to be a transparent member, but is preferably made of a material having good heat conductivity. Different sample liquids (dialysates at different parts of the dialyzer) are accommodated in the containers 2 and can be held by being inserted through the holding holes 3a (see FIG. 3) of the holder 3, respectively. The holder 3 has a holding hole 3b in addition to the holding hole 3a. The holder 3 holds the wiping container 11 in one holding hole 3b while holding the container 2 in the six holding holes 3a. It is possible to hold it.

  On the other hand, as shown in FIG. 3, the main body 1 is formed with a motor M, a pulley P2 driven by the motor M, and a pulley P1 on which the belt 12 can be suspended between the pulley P2. The holder 3 is connected to the belt 12 via an interlocking member 13. When the motor M is driven to rotate the belt 12, the holder 3 moves linearly in the bat 10 along the belt 12. Thus, if the holder 3 is moved to a desired position, any one of the held containers 2 or the wiping container 11 is set to a predetermined position (a measurement position that is a position below the thermistor 5 and the vibrating needle 6). it can. In addition, the code | symbol S1, 2 in the figure has shown the said sensor for positioning.

  The cooling tank 7 is made of a heat insulating material or the like having an accommodation space therein, and is configured to contain an antifreeze liquid and a cooling means 8 for cooling the antifreeze liquid as shown in FIG. is there. The cooling means 8 is composed of a cooling thermomodule, for example, a Peltier element 8a whose surface faces the inside of the cooling tank 7 (an element whose front side is cooled by flowing current and the back side is heated by that amount), Fins 8b for heat dissipation are formed on the back side. In addition, it can replace with the Peltier element 8a and can be used as the general purpose cooling means which can cool the antifreeze liquid in the cooling tank 7.

  Further, as shown in FIG. 2, a guide member 9 is inserted from the upper surface to the inside of the cooling tank 7. The guide member 9 has a space that can accommodate the container 2 and the wiping container 11 while being open at the top, and supports the bottom surfaces of the container 2 and the wiping container 11 as shown in FIG. And a spring 15 for urging the support portion 14 upward in the drawing. A notch 9a is formed on a side surface of the guide member 9 located inside the cooling tank 7, and the inside of the cooling tank 7 and the inside of the guide member 9 communicate with each other, and the antifreezing liquid in the cooling tank 7 is guided by the guide member. 9 is also filled.

  The moving means 4 includes an operating rod 4b extending upward from the upper surface of the main body 1 and a driven rod 4a that operates together with the operating rod 4b. The thermistor 5 capable of detecting the temperature of the sample liquid. (Temperature detection means) and the inside of a predetermined one (positioned at the measurement position) among the plurality of containers 2 held by the holder 3 by moving the vibration needle 6 (vibration means) for applying vibration to the sample liquid The container 2 can be moved downward together with the thermistor 5, and the container 2 with the thermistor 5 inserted (the same applies to the wiping container 11) can be moved into the cooling tank 7. Is. However, the thermistor 4b moves up and down when the actuating rod 4b expands (moves in the direction in which the moving means 4 moves away from the upper surface of the main body 1) or contracts (in the direction in which the moving means 4 approaches the upper surface of the main body 1). 5 and the vibrating needle 6 can move up and down.

  Thus, the container 2 (or the wiping container 11) is positioned above the guide member 9 (that is, the position below the thermistor 5 and the vibrating needle 6 and the measurement position), and the bottom surface of the container 2 (the support portion 14). When the operating rod 4b is contracted and the thermistor 5 and the vibrating needle 6 are moved downward in the state where the thermistor 5 and the vibrating needle 6 are moved downward, as shown in FIG. It can be inserted into the container 11). In this state, as shown in the figure, the tip side of the thermistor 5 and the vibrating needle 6 is immersed in the sample liquid in the container 2 (or the wiping container 11), and the end face of the driven rod 4a (the thermistor 5 and the vibrating needle). 6 is attached to an opening edge of the container 2 (or the wiping container 11).

  Therefore, if the operating rod 4b is further contracted and the driven rod 4a is lowered, the container 2 (or wiping container 11) at the measurement position can be moved downward together with the thermistor 5 and the vibrating needle 6, and the thermistor Thus, the container 2 (or the wiping container 11) in a state where the 5 and the vibrating needle 6 are inserted can be moved into the cooling tank 7. More specifically, the container 2 (or the wiping container 11) pressed by the driven rod 4a descends against the urging force of the spring 15 while being supported by the support portion 14, and reaches the inside of the guide member 9. Then, it is immersed in the antifreeze liquid cooled by the cooling means 8.

  By immersing the container 2 in the antifreeze liquid as described above, the sample liquid stored inside is rapidly cooled. Thus, after the sample liquid in the container 2 is supercooled, the vibrating needle 6 is driven to vibrate, and by the vibration, freezing stimulation is applied to convert the solid and liquid into a coexisting state (solid-liquid coexisting state). . By detecting the temperature at this time with the thermistor 5, the coagulation temperature of the sample liquid can be measured, and the osmotic pressure can be analyzed based on the coagulation temperature. Thereby, since the osmotic pressure in the sample solution in the container 2 can be analyzed, it is possible to determine whether or not the dialysate is generally desired by using the value as an index.

  That is, if the thermistor 5 and the vibrating needle 6 are inserted into the container 2 by the moving means 4 and the container 2 is further lowered by the moving means 4 and reaches the guide member 9 while maintaining the state, the antifreeze liquid in the cooling tank 7 is obtained. If the temperature at which the internal sample liquid is rapidly cooled and the sub-cooled state is vibrated by the vibrating needle 6 and becomes a solid-liquid coexistence state is detected by the thermistor 5, The coagulation temperature (that is, osmotic pressure) of the sample solution can be measured.

  After the measurement, when the actuating rod 4b is extended and the driven rod 4a is raised, the container 2 and the support portion 14 are also raised by the urging force of the spring 15, and the support portion 14 is at the initial position. While the container 2 stops, if the operating rod 4b is further extended from there and the driven rod 4a is raised, the thermistor 5 and the vibrating needle 6 are separated upward from the container 2 and returned to the initial position. Thereby, the measurement operation for one sample solution is completed.

  As shown in FIG. 14, the osmotic pressure analyzer includes a wiping means 16 for wiping the thermistor 5 as a temperature detecting means and the vibrating needle 6 as a vibrating means, as described above. The wiping container 11 containing the wiping means 16 is held in the holding hole 3b (see FIG. 3) of the holder 3. The wiping means 16 is made of a sponge accommodated on the bottom surface in the wiping container 11, and the tip of the wiping means 16 is inserted into the wiping container 11 while the thermistor 5 and the vibrating needle 6 moved by the moving means 4 are inserted into the wiping container 11. The sample liquid and the like adhering to the side can be wiped off by the absorption action of the sponge.

  Here, in this embodiment, the pre-cooling means 17 is attached to the lower surface of the bat 10 that supports the lower surface of the container 2 that is made of a metal member having excellent heat conductivity and is held by the holder 3. The pre-cooling means 17 is configured to be able to cool the container 2 held by the holder 3 by cooling the bat 10. For example, the pre-cooling means 17 is similar to the cooling means 8 disposed in the cooling tank 7. It consists of a thermo module.

  More specifically, the cooling thermo module as the pre-cooling means 17 is, for example, a Peltier element whose surface is closely fixed to the bottom surface of the bat 10 (the surface side is cooled by flowing current, and the back side is heated accordingly. And fins (not shown) for heat dissipation may be formed on the back side thereof. It should be noted that a general-purpose pre-cooling means that can cool the container 2 via the bat 10 instead of the Peltier element may be used, or the bat 10 may be cooled together with the cooling tub 7 by being connected to the cooling means 8. You may comprise.

  6 to 9, the bat 10 according to this embodiment has a concave shape that follows the bottom surface of the container 2 held by the holder 3 (in this embodiment, an arc shape as shown in FIG. 9). 10a and the lower surface of the container 2 is supported by the concave shape 10a. More specifically, the concave shape 10a is a groove-like shape formed by extending in the longitudinal direction at the approximate center of the bat 10, and is in contact with and supported along the lower surface of the container 2 together with the holder 3 and the container. 2 (same for the wiping container 11) can be allowed to move. In addition, the code | symbol 10b in the same figure has shown the through-hole which faced the cooling tank 7. FIG.

  Furthermore, in this embodiment, the holder 3 can hold a plurality of (six) containers 2 and (one) wiping container 11 in a straight line, and the container 2 (six containers 6) containing the sample liquid to be measured. Any one of the containers 2) and the wiping container 11 can be alternately moved to positions below the thermistor 5 and the vibrating needle 6. Specifically, in the initial state, the wiping container 11 is located below the thermistor 5 and the vibrating needle 6 (see FIG. 10), and the operation means 19 of the main body 1 is operated to start measurement. Then, first, the motor M is driven to rotate forward to move the holder 3 to the left side in the figure, and the container 2 closest to the wiping container 11 is positioned below the thermistor 5 and the vibrating needle 6 (measurement position). To move.

  When the thermistor 5 and the vibrating needle 6 are lowered by the moving means 4, the thermistor 5 and the vibrating needle 6 are inserted into the container 2, and the tip side is immersed in the internal sample solution. The container 2 is lowered and reaches the guide member 9, and is cooled by being immersed in the antifreeze liquid in the cooling tank 7 (see FIG. 11). Thus, after the osmotic pressure of the sample liquid in the container 2 is analyzed, the thermistor 5 and the vibrating needle 6 are raised by the moving means 4.

  Thereafter, the motor M is driven in reverse to move the holder 3 to the right side in the drawing to return to the initial state (see FIG. 10), and the thermistor 5 and the vibrating needle 6 are lowered by the moving means 4 and inserted into the wiping container 11. By doing so, the tip side is brought to the internal wiping means 16. At this time, the sample liquid adhering to the tip side is wiped off by the wiping means 16 made of sponge (see FIG. 12). After such a wiping operation, the thermistor 5 and the vibrating needle 6 are raised by the moving means 4 and the motor M is driven to rotate forward to move the holder 3 to the left again in the figure, and this time from the position closest to the wiping container 11. The second container 2 is moved to a position below the thermistor 5 and the vibrating needle 6 (see FIG. 13).

  Thereafter, the osmotic pressure analysis is sequentially performed on the sample liquid in the container 2 while the wiping operation by the wiping means 16 is interposed. In this way, the container 2 containing the sample solution and the wiping container 11 containing the wiping means 16 are alternately moved to a position below the thermistor 5 and the vibrating needle 6 to measure the coagulation temperature and the wiping operation. By alternately performing the above, it is possible to suppress the sample liquid adhering to the thermistor 5 and the vibrating needle 6 during the previous measurement from remaining until the next measurement and adversely affecting the measurement accuracy.

  Here, in the present embodiment, as described above, the container 2 is cooled in advance by the pre-cooling means 17 via the bat 10 in the process of sequentially performing measurement and osmotic pressure analysis on the sample liquid in the container 2. Therefore, the sample liquid in the waiting container 2 is cooled to a predetermined temperature, and the time until the sample liquid is inserted into the cooling bath 7 and is in a supercooled state can be shortened.

  Therefore, according to the above embodiment, since the pre-cooling means 17 for cooling the container 2 held by the holder 3 is provided, the measurement / analysis is waited for among the plurality of containers 2 held by the holder 3. However, the time until the sample solution is brought into a supercooled state can be shortened by using the waiting time. The bat 10 is made of a metal member having excellent heat conductivity and supports the lower surface of the container 2 held by the holder 3, and the precooling means 17 cools the container 2 by cooling the bat 10. Since it was comprised so that the container 2 in standby could be cooled in advance with an efficient and simple structure.

  Furthermore, the bat 10 has a concave shape 10a that follows the lower surface of the container 2 held by the holder 3, and the lower surface of the container 2 is supported by the concave shape 10a. Can be increased, and the standby container 2 can be cooled more efficiently. The pre-cooling means is not limited to the one that cools the bat 10 and indirectly cools the container 2, but cools the container 2 held by the holder 3 to directly cool the container 2 in the standby state. You may comprise.

  Furthermore, a vibrating needle 6 (vibrating means) that is inserted into the container 2 and imparts vibration to the sample liquid is provided, and the vibrating needle 6 is moved by the moving means 4 together with the thermistor 5 (temperature detecting means). Since the moving means 4 allows the vibrating needle 6 and the thermistor 5 to be immersed in the sample solution at the same time. Note that the vibrating needle 6 may not be provided on the driven rod 4a, and other forms of freezing stimulus applying means that can apply freezing stimulus such as vibration to the supercooled sample liquid may be used.

  According to this embodiment, the wiping container 11 containing the wiping means 16 is held by the holder 3, and the thermistor 5 and the vibrating needle 6 moved by the moving means 4 are inserted into the wiping container 11. While the wiping means 16 can be wiped off, it is possible to improve the workability by eliminating the need for a wiping operation by the operator, and to eliminate the need for a separate drive mechanism for wiping and to suppress the manufacturing cost. Can be simplified.

  That is, according to the present embodiment, the container 2 is placed in the cooling tank 7 by the cooperative operation of the moving means 4 that moves the thermistor 5 and the vibrating needle 6 up and down and the motor M that moves (slides) the holder 3 left and right. Since the osmotic pressure analysis operation can be performed by moving it, the wiping operation by the wiping means 16 can be performed by the same cooperative operation, so that a separate driving mechanism for wiping is unnecessary. is there. Instead of the moving means 4 or the motor M, other driving mechanisms may be used as long as the thermistor 5 and the vibrating needle 6 can be moved up and down and the holder 3 can be slid.

  Although the present embodiment has been described above, the present invention is not limited to this. For example, the wiping container 11 containing the wiping means 16 is not held by the holder 3 (the wiping operation is not performed during the measurement process). It can be applied to an osmotic pressure analyzer. That is, in this embodiment, the holder 3 can hold a plurality of containers 2 and a wiping container 11, and the container 2 containing the sample liquid to be measured or the wiping container 11 is alternately connected to the thermistor 5 (temperature detection). However, only a plurality of containers 2 are held by the holder 3 so that the measurement of the coagulation temperature and the analysis of the osmotic pressure are performed sequentially without wiping. Also good.

  Further, in the present embodiment, the holder 3 is linearly slid while holding the plurality of containers 2 and the wiping container 11, but is formed in an annular shape and moves in the circumferential direction, for example. There may be. Of course, the holder 3 need only hold a plurality of containers 2, and may hold a number of containers 2 other than six. In this embodiment, the dialysate is applied as the sample solution. However, the osmotic pressure may be analyzed using another sample solution. Furthermore, instead of the thermistor 5, it may be another temperature detecting means that can be moved by a moving means and inserted into the container to detect the temperature of the sample liquid.

  As long as the osmotic pressure analyzer is provided with a pre-cooling means for cooling the container held by the holder, it can be applied to other forms and applications.

1 is a schematic external view showing an osmotic pressure analyzer according to an embodiment of the present invention. The schematic diagram which shows the positional relationship of the container and holder which hold | maintained the container for wiping, and a cooling tank in the same osmotic pressure analyzer. Schematic showing the drive mechanism of the holder in the same osmotic pressure analyzer The schematic diagram which shows the positional relationship of the container (wiping container) and the guide member 9 in the same osmotic pressure analyzer. The schematic diagram which shows the state which the container descend | falls from the state of FIG. 4 and was accommodated in the guide member 9 Top view showing a bat in the same osmotic pressure analyzer VII-VII line sectional view in FIG. VIII-VIII sectional view taken on the line in FIG. IX-IX line sectional view in FIG. Schematic diagram showing a state in which the holder in the osmotic pressure analyzer is in the initial state and the thermistor is in the initial position. The schematic diagram which shows the state which the holder in the same osmotic pressure analyzer moved and the said container was moved in the cooling tank, inserting a thermistor in the 1st container. The schematic diagram which shows the state which the holder in the same osmotic pressure analyzer moved and the said container was moved in a cooling tank, inserting a thermistor in the container for wiping The schematic diagram which shows the state which the holder in the same osmotic pressure analyzer moved and the said container was moved in the cooling tank, inserting the thermistor in the 2nd container. The schematic diagram which shows the wiping means accommodated in the container for wiping in the same osmotic pressure analyzer

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Main body 2 Container 3 Holder 4 Moving means 5 Thermistor (temperature detection means)
6 Vibrating needle (vibration means)
DESCRIPTION OF SYMBOLS 7 Cooling tank 8 Cooling means 9 Guide member 10 Butt 10a Concave shape 11 Wiping container 12 Belt 13 Interlocking member 14 Support part 15 Spring 16 Wiping means 17 Precooling means 18 Screen with touch key 19 Operation means

Claims (4)

A container capable of holding a predetermined amount of sample liquid;
A holder for holding a plurality of the containers;
A cooling tank in which an antifreeze is contained and a cooling means for cooling the antifreeze is disposed;
The temperature detection means capable of detecting the temperature of the sample liquid is moved so that it can be inserted into a predetermined one of the plurality of containers held by the holder, and the container can be moved together with the temperature detection means. A moving means capable of moving the container in a state where the temperature detecting means is inserted into the cooling tank;
And after the sample liquid in the container is supercooled, the temperature detecting means detects the temperature when the solid and liquid are converted into a coexisting state by applying freezing stimulation by vibration. In an osmotic pressure analyzer that analyzes the osmotic pressure by measuring the coagulation temperature of the sample liquid,
An osmotic pressure analyzer comprising pre-cooling means for cooling the container held by the holder.   The bat comprises a metal member having excellent heat conductivity and supports the lower surface of the container held by the holder, and the precooling means is configured to cool the container by cooling the bat. The osmotic pressure analyzer according to claim 1.   3. The osmotic pressure analyzer according to claim 2, wherein the bat has a concave shape that follows the lower surface of the container held by the holder, and the lower surface of the holder is supported by the concave shape. .   It is provided with a vibrating means that is inserted into the container and imparts vibration to the sample liquid, and the vibrating means is moved by the moving means together with the temperature detecting means and reaches the sample liquid. The osmotic pressure analyzer according to any one of claims 1 to 3.

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