JP2009247512A - Biological optical measurement probe for simultaneous electroencephalographic measurement and biological optical measurement apparatus using same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide: a safe biological optical measurement probe stably executing optical measurement and electroencephalographic measurement; and a biological optical measurement apparatus using the same. <P>SOLUTION: A plurality of optical fiber fixing devices for fixing an incident optical fiber and a detecting optical fiber are formed with recesses for housing electroencephalographic electrodes, at their bases in a side coming into contact with a skin, into a shape fitted to the shape of the electroencephalographic electrodes. The electrode used has a hole formed in its upper part, the distal end of the optical fiber fixed by the fixing device is inserted into the hole of the electrode and the electrode is fitted in the groove. The fixing device base and the electrode base have substantially same heights and the optical fiber distal end is installed at a substantially same height to or a slightly projecting from the base. A handle-like portion of the electrode or a cable is made to pass through a cut of the fixing device base edge portion, so that the optical fiber and the electrode stably come into contact with the skin. When bringing them into contact with the skin, cream-like electroencephalographic paste is applied to the inside of the collodion electrode so as to prevent the optical fiber distal end alone from biting into the skin to cause pain. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a living body light measurement technique for measuring a metabolite concentration in a living body or a change in the concentration using light, and more particularly, a living body light measuring probe for measuring a metabolite concentration in a subject's head, and a probe for the same. It is related with the used biological light measuring device.

A technology (biological light measurement device) that measures blood volume changes in the cerebral cortex due to brain activity at multiple points and displays the blood volume changes as moving images or still images has already been developed in "Medical Physics, vol.22, No.
12, pp1997-2005 (1995) ”.

  In addition, a report that the electroencephalogram was measured at the same time as measuring the blood volume change with a biological light measurement device was published in "Neuroimage. 2002 Jul; vol. 16 (3 Pt 1): pp587-592 (2002)". However, the conventional biological light measurement probe and the electroencephalogram electrode are used together.

  As described above, since it is difficult to use what is used alone, it has already been done as follows.

  (1) A technique for inserting an electroencephalogram electrode with a hole into the tip of an optical fiber is described in Japanese Patent Application Laid-Open No. 2003-149137.

  (2) Japanese Patent Application Laid-Open No. 2006-187304 describes a technique for attaching an electroencephalogram electrode on a connecting portion for connecting fixtures for fixing an optical fiber.

  (3) Japanese Patent Application Laid-Open No. 2006-223503 discloses a technique in which a socket for attaching an electroencephalogram electrode is provided on a connecting portion for connecting fixtures for fixing an optical fiber.

Atsushi Maki, et al .: Spatial and temporal analysis of human motor activity Medical Physics, vol.22, No.12, pp1997-2005 (1995) R. P. Kennan, et al .: Simultaneous recording of event-related auditory oddball response using transcranial near infrared optical topography and surface EEG, Neuroimage 2002 Jul, vol.16 (3 Pt 1), pp587-592 (2002) JP 2003-149137 A JP 2006-187304 A JP 2006-223503 A

  However, the above-described biological optical measurement probe has the following problems.

  The electroencephalogram electrode must be pressed against the skin to reduce the impedance. However, the above-described method of providing an electroencephalogram electrode or an electroencephalogram electrode socket on the connection portion has a problem that the electroencephalogram electrode cannot be sufficiently pressed and brought into contact with the skin at a relatively thin and elastic connection portion. On the other hand, the technique of making a hole in the electrode and inserting the tip of the optical fiber can simultaneously hold the optical fiber. However, it is impossible to maintain a stable contact state only by inserting, and since the actual electrode has a handle-like part for attaching the cable, not just a dish, the optical fiber itself is not stable and aggressive. In addition, if the electroencephalogram electrode is punctured, the impedance itself changes, which makes it impossible to measure the electroencephalogram itself.

  The present invention has been made in order to solve such problems, and the optical fiber and the electroencephalogram electrode are both in contact with the skin in a stable manner, and the biomedical optical probe capable of simultaneously measuring the electroencephalogram with high safety. And it aims at providing the living body optical measuring device using the same.

  In order to achieve the above object, the present invention has the following features.

  On the bottom surface of the plurality of optical fiber fixtures that fix the incident optical fiber and the detection optical fiber on the side in contact with the skin, a recess is formed in which the electroencephalogram electrode matching the shape of the electroencephalogram electrode is accommodated. A collodion electrode having a shape with a hole in the upper part is used, and the tip of the optical fiber fixed by a fixture is inserted into the hole of the collodion electrode, and the collodion electrode is inserted into the recess. The bottom of the fixture and the bottom of the electrode should be almost the same height, and the tip of the optical fiber should be placed so that it is almost the same height or slightly protruding. There is a notch at the edge of the bottom of the fixture, and the handle or cable of the electrode passes through this notch, so that the optical fiber and the electrode can be brought into stable contact with the skin. When contacting the skin, the cream-like electroencephalogram paste is applied to the inside of the above-mentioned collodion electrode, so that only the tip of the optical fiber is hard to cause skin and no pain is generated. If the electrode is not attached, it is the same shape as the electrode, but it is not dish-shaped, and a soft material with a flat bottom is fitted into the recess, causing no pain.

  In this way, optical measurement and electroencephalogram measurement can be performed stably, and a safe probe can be provided.

Hereinafter, typical configuration examples of the present invention will be listed.
(1) One or a plurality of irradiation optical fibers for irradiating the subject with light and one or a plurality of detections for detecting the light irradiated from the irradiation optical fiber and propagated through the inside of the subject A biological optical measurement probe having a plurality of optical fiber fixtures for fixing the optical fiber for irradiation, and the optical fiber for irradiation and the optical fiber for detection, respectively, for an electroencephalogram with a hole in the center An electrode (colodion electrode) is used, and the irradiation or detection optical fiber is disposed so as to pass through the hole of the electrode.
(2) In the biological light measurement probe according to (1), the bottom surface of the fixture that is in contact with the skin has a depression that is recessed in the shape of an electroencephalogram electrode.
(3) In the biological optical measurement probe according to (1)-(2), the irradiation or detection optical fiber fixed to the fixture is arranged so as to be substantially coaxial with the hole of the electroencephalogram electrode. It is characterized by being.
(4) In the biological light measurement probe according to (1) to (3), the bottom surface of the fixture that is in contact with the skin and the bottom surface of the electroencephalogram electrode that is fitted in the depression are substantially the same height. Features.
(5) In the biological light measurement probe according to (1) to (3), the tip of the irradiation or detection optical fiber is substantially the same height as the bottom surface of the fixture or the bottom surface of the electroencephalogram electrode. Or it arrange | positions so that it may protrude a little.
(6) In the biological optical measurement probe according to (5), the length of the tip of the irradiation or detection optical fiber protruding from the skin bottom surface of the fixture or the bottom surface of the electroencephalogram electrode is about 0 to about It is characterized by being 1 millimeter.
(7) In the biological optical measurement probe according to (1) to (6), when an electroencephalogram electrode is not used, the depression is filled with an embedding member having substantially the same shape as the electroencephalogram electrode, and the surface in contact with the skin is substantially flat. It is characterized by.
(8) In the biological optical measurement probe according to any one of (1) to (7), a part of one or a plurality of electrodes or a cable of an electrode may be attached to an edge of the bottom surface of the fixture in contact with the skin. It is characterized by a notch for threading.
(9) In the biological light measurement probe according to (8), an angle formed by a substantially center of the notch for passing the cable of the electrode and a center line of the optical fiber drawn from the fixture is 11.5 degrees to 180 degrees. It is a value between degrees.
(10) In the biological optical measurement probe according to (1) to (9), the fixture and the embedding member are formed of a soft material such as rubber or gel.
(11) A living body light measuring device having the living body light measuring probe according to (1) to (10).

  According to the present invention, it is possible to stably perform optical measurement and electroencephalogram measurement, and to realize a safe biological light measurement probe and a biological light measurement apparatus using the probe.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

  FIG. 1 is a diagram showing a configuration of a base of a fixture that is a part of an optical fiber fixture of a biological light measurement probe according to an embodiment of the present invention. This is used with the lid shown in FIG. FIG. 1 shows (a) a bird's-eye view, (b) a bird's-eye view, (c) a perspective view as viewed from the side, and (d) of the base of the optical fiber fixture constituting the biological light measurement probe of the present invention. A cross-sectional view seen from the side is shown. An optical fiber insertion port 3 and an optical fiber port 4 are open in the base 1, and the side in contact with the skin is the bottom 2. The diameter of the base 1 and the diameter of the bottom 2 may be substantially the same, but it is desirable that the diameter of the bottom 2 is large for stability. In addition, although the base 1 has a thinned portion, this is a portion through which a connecting portion for connecting optical fiber fixtures (not shown) is passed. This thin part may not be present. A notch 5 is formed at the edge of the bottom 2. The width of the maximum portion of the notch 5 is preferably substantially the same as or slightly larger than the width of the electrode handle 12 (FIG. 3). In this case, two notches 5 are formed. There may be one notch 5, or three or four. A recess 6 is formed from the bottom 2 to the base 1. The shape of the recess 6 is almost the same as that of the electroencephalogram electrode (colodion electrode) with a hole shown in FIG. 3, so that the electrode can be completely accommodated. The depth of the recess 6 is substantially the same as the thickness d of the electroencephalogram electrode shown in FIG. As a material forming the optical fiber fixture, it is desirable to use a soft material having biocompatibility such as silicon rubber and gel. Of course, a hard material such as resin may be used.

  FIG. 2 is a view showing a configuration of a lid portion of a fixture that is a part of the fixture of the biological light measurement probe according to the embodiment of the present invention shown in FIG. It is used by covering the base of the optical fiber fixture shown in FIG. FIG. 2 shows (a) a bird's-eye view, (b) a bird's-eye view, (c) a view from the side, (d) a side view of the lid of the fixture constituting the biological light measurement probe of the present invention. A cross-sectional view is shown. The lid portion 7 has an optical fiber holding portion 8 that is inserted into the upper portion of the optical fiber insertion port 3 of the fixture base 1 and an insertion portion 9 that is inserted into the optical fiber port 4 of the base portion 1. The pressing portion 8 is fitted into the upper portion of the optical fiber insertion port 3 and pressed so that the optical fiber does not come off. The insertion portion 9 is formed with a non-slip protrusion, and the optical fiber port 4 is formed with a groove corresponding thereto, so that the lid portion 2 is fitted into the base portion 1 so as not to slip. The insertion portion 9 is cut so that an optical fiber can pass therethrough. The optical fiber is inserted from the insertion port 3 of the base 1 and installed so as to protrude into the recess 6 through the optical fiber port 4. The tip of the optical fiber is installed so as to be almost the same height as the bottom 2 or slightly protrude from the bottom. Further, cover the cover 7 and hold it so that the optical fiber does not come off. The lid portion 7 and the base portion 1 may be adhered or may be closed only by the insertion portion.

  FIG. 3 shows the configuration of the electroencephalogram electrode. This is a so-called collodion electrode with a hole for injecting cream for electroencephalogram. In the present invention, the electroencephalogram cream or paste is applied directly to the inside of the electrode. The electroencephalogram electrode is usually made of silver. Since silver is easy to oxidize, it is used after it has been preliminarily immersed in saline to form a silver oxide film on the surface. An electrode hole 11 is opened in the electrode 10, and an electrode handle 12 for joining a cable 13 for connection to an electroencephalograph protrudes. The electrode 10 has a bowl-like shape, and an electroencephalogram cream or paste is applied to the inside of the electrode 10 to adhere to the skin. Usually, the diameter r of the hole 11 is about 2 millimeters and the electrode thickness d is between 2 and 3 millimeters.

  FIG. 4 is an image diagram of a state in which an optical fiber is inserted into an optical fiber fixture and an electroencephalogram electrode is also attached. An optical fiber 14 is inserted into the base 1 and a lid 7 is fitted, and an electrode handle 12 and a cable 13 connected to the electrode handle 12 are pulled out from a notch 5 in the bottom 2. By pulling out the handle 12 in this way, the bottom 2 can come into contact with the skin without floating, and the recess 6 in FIG. 5 is brought into contact with the electrode 10 so that the electrode 10 is pressed against the skin. Can be brought into stable contact with the skin without floating.

  FIG. 5 is a cross-sectional view of the image diagram shown in FIG. An optical fiber 14 is inserted into the base 1 and the lid 7 is covered from above. There is an optical fiber support portion 15-2 having a convex portion in the middle of the optical fiber 14, and the convex portion engages with a groove inside the optical fiber insertion port 3 so that the optical fiber 14 does not come off. Further, the optical fiber 14 is arranged so that the optical fiber tip 15-1 protrudes into the recess 6 through the optical fiber port 4. The optical fiber tip 15-1 also has a convex portion that engages with the groove inside the optical fiber port 4 so that it does not protrude too much into the recess 6. An electroencephalogram electrode 10 is fitted in the recess 6. The hole 11 of the electroencephalogram electrode, the optical fiber port 4 and the optical fiber tip 15-1 are arranged so as to be substantially coaxial, and the optical fiber tip 15-1 protruding from the optical fiber port 4 is in the hole 11 of the electrode. Inserted. The diameter of the optical fiber tip 15-1 is substantially the same as or slightly smaller than the diameter r of the hole 11 of the electrode. The diameter of the optical fiber tip 15-1 other than the portion through which the hole 11 is passed is larger than r, and it also serves as a stopper so that the optical fiber tip 15-11 does not protrude beyond the bottom of the electrode. Yes. Since the electrode handle 12 is a cross-sectional view, it is difficult to understand, but the electrode handle 12 is drawn from the notch 5 in the bottom 2. An electroencephalogram paste or cream is applied to the inside of the electrode 10 so that the surface is flat or slightly piled up. Since the paste or cream is white, near infrared light passes through, but it is scattered. Therefore, wiping only the end face of the optical fiber tip 15-1 improves the measurement efficiency. When the electrode is pressed, the paste or cream layer attached to the end face becomes thin, so it does not have to be wiped off. When measuring a newborn baby, the pressing is refrained, but the influence on the measurement is small because the skin is easy to transmit light.

  FIG. 6 is a cross-sectional view similar to FIG. The details are almost the same as in FIG. 5 except that the handle 12 of the electrode is bent and the handle 12 and the cable 13 are released through the notch 5. The notch 12 is widest on the inside and is almost the same width as or slightly wider than the handle of the electrode, and the width becomes narrower as it approaches the edge. It is possible to make it. With this configuration, since the cable 13 is separated from the head, the operation of the cable 13 is facilitated. However, when measuring in the sleeping state, the handle 12 may be attached to the portion under the body in the state of FIG. 5 because the handle 12 is less likely to be damaged by the weight of the body.

  FIG. 7 is a top view of another embodiment of the optical fiber fixture. The variation of the notch 5 of the bottom part 2 is shown. In FIG. 1, two incisions 5 are shown in FIG. 1, but FIG. 7 (a) is an example in which two are facing in different directions, (b) is three examples, and (c) is four examples. , (D) and (e) are all embodiments having one notch, but variations in different directions. Which notch is passed through the handle 12 is determined depending on the positional relationship with the optical fiber 14 and which part of the head is measured depending on which direction the cable 13 is taken out and easy to use. For example, when the optical topography main body is on the right side of the head and the electroencephalograph main body is on the left side, the optical fiber fixing device can be rotated to adjust the direction in which the optical fiber exits. Then, the handle 12 of the electroencephalogram electrode is selected and passed through the notch 5 facing the left side. Further, when measuring a sleeping newborn, the optical fiber fixing device arranged in the back of the head passes the cable through the notch 5 in a direction that allows the cable 13 to pass through between adjacent fixing devices so that the weight is not applied to the cable 13. Note that the slits 5 are formed so as to be symmetric, but they may be formed asymmetrically.

FIG. 8 is a diagram showing a positional relationship among the optical fiber insertion port 3, the cut 5, and the electroencephalogram electrode 10. FIG. 8A is a view from above, and FIG. 8B is a cross-sectional view. Here, the size of each part will be described.
W: width of notch; 2-5 mm, d1: diameter of optical fiber support; 2-5 mm, d2: diameter of optical fiber; 1-3 mm, L: diameter of electroencephalogram electrode; about 10 mm, t: height of constriction 2-10 mm, D1: diameter of the constriction of the optical fiber fixture; 5-10 mm, D2: diameter of the upper portion of the optical fiber fixture; 8-15 mm, D3: diameter of the base of the optical fiber fixture; 10- 15mm.

  18-1 is the center line of the optical fiber insertion port 3, and 18-2 is the center line of the notch 5. In order to prevent the pattern of the optical fiber and the electrode from colliding with each other, the minimum value of the angle θ formed by 18-1 and 18-2 is expressed by the following equation.

θ ＝ sin ^-1 ((d2 + W) / D2) ... (1)
Since the maximum value of θ is when the optical fiber insertion slot and the cut are on a straight line, the range of θ is expressed by the following equation.

180 ° ≧ θ ≧ sin ⁻¹ ((d2 + W) / D2). . . (2)
When converted using the minimum value of d2, the minimum value of W, and the maximum value of D2, the range of θ is approximately 11.5 ° to 180 °.
Although not shown, since the length of the electrode handle 12 is about 10 mm, if the height t is 10 mm or more,
The minimum value of θ may be smaller than the above range (2). However, in reality, if t is large, the fixture becomes unstable.

  FIG. 9 shows a filling member used when the electrode 10 is not fitted in the recess 6. The filling member 16 has substantially the same shape as the electrode 10, but has no handle and does not have a hook shape. Only the hole 17 of the filling member is opened, and the bottom surface is flat. The diameter of the hole 17 is almost the same as r, but a slightly smaller one is better. In particular, when the filling member is molded from a soft material, if the diameter is the same as or slightly smaller than the narrow portion of the optical fiber tip 15-1, the filling member will not easily fall out of the tip 15-1. It is desirable that the thickness be substantially the same as the thickness d of the electrode so that when the filling member 16 is fitted into the recess 5, there is almost no step between the bottom portion 2 and the filling member 16 or is small.

  FIG. 10 is a cross-sectional view when an optical fiber is inserted into an optical fiber fixture and a filling member is fitted. The details are almost the same as those in FIG. 5, but a filling member 16 is fitted in the recess 5. Since the optical fiber tip 15-1 is almost the same height as the bottom surface of the filling member 16 or slightly protrudes (1 mm or less), there is no problem of biting into the skin and it is safe.

  In FIG. 11 and subsequent figures, a configuration is shown in which the above-described optical fiber fixture and the optical fiber fixture to which an electroencephalogram electrode is attached are mounted on the subject.

  FIG. 11 is an image diagram showing an example of the configuration of a biological light measurement probe according to an embodiment for realizing mounting on a subject according to the present invention. In FIG. 11 (a), a vertical fixing portion 19 for keeping an optical fiber fixing tool at a substantially constant distance is bonded to a cap 21 made of a stretchable material. The stretchable material is, for example, a stretchable cloth. The vertical fixing portion 19 is provided with three rings 20 for inserting optical fiber fixtures. As shown in FIG. 11 (b), the ring 20 of the vertical fixing portion 19 is connected by a connecting member 22, and the connecting member 22 is configured to be rotatable about the ring 20. As shown in FIG. 13 (a), the means may be such that the ring 20 and the ring of the connecting member 22 are fitted together in the constricted portion 1-2 of the optical fiber fixture 1, or as shown in FIG. 13 (b). In addition, the ring 20 may be provided with a groove-like fixing portion into which the connecting member 22 can be fitted. Further, as shown in FIG. 13 (c), a part 20-1 that is different from the ring 20 and that is fixed by fitting the ring of the ring 20 and the connecting member 22 may be prepared. An electroencephalogram electrode may be attached to a part or a plurality of parts of the stretchable material.

  FIG. 12 shows a state where the probe of FIG. The elastic material cap 21 is extended, and accordingly, the connecting member 22 is rotated about the center of the ring 20 into which the fixing tool (the base 1 and the lid portion 7) is inserted, and the interval between the vertical fixing portions 19 is widened. Since the material of the vertical fixing portion 19 and the connecting member 22 is not substantially stretchable, the portion to which the vertical fixing portion 19 is bonded does not extend, and the ring 20 on the adjacent vertical fixing portion 19 connected by the connecting member 22 is not stretched. Probes can be fitted to heads of various sizes while maintaining a constant distance between each other.

  FIG. 13 is a cross-sectional view showing the positional relationship between the fixing base 1 and the ring 20 of the vertical fixing portion 19 and the connecting member 22 as described above. In FIG. 13A, the ring 20 and the connecting member 22 are fastened by inserting the base 1. The connecting member 22 rotates around the base 1. FIG. 13 (b) is an embodiment in which there are protrusions for fastening the connecting member to the ring 20. The connecting member 22 is fitted into the protruding portion of the ring 20 and rotates around the protruding portion of the ring 20. In FIG. 13 (c), the connecting member 22 is fastened by using a component 20-1 for fitting and fixing the ring 20 and the ring of the connecting member 22. The connecting member 22 rotates around the part 20-1.

  FIG. 14 uses a resin net (netron) 24 instead of the stretchable material 21 of FIG. The resin net 24 expands and contracts in one direction, but does not extend in another direction. This non-extending direction is used as the vertical fixing portion 19, and the rings 20 are fixed at equal intervals in the non-extending direction. This distance is 2 or 3 centimeters as before. As shown in FIG. 14, a portion where the direction of the vertical fixing portion 19 does not match may be used by connecting a plurality of resin nets and switching the direction. An electroencephalogram electrode may be attached to a part or a plurality of parts of the net.

  FIG. 15 shows a state where the probe of FIG. The function is the same as in FIG.

  FIG. 16 is the same as the probe using the resin net of FIG. 15, but cuts off the unused net portion so that it can be worn, for example, avoiding the ears.

  FIG. 17 shows the probe of FIG.

  FIG. 18 shows a configuration in which the net of the net is used as a substitute for the ring 22 in addition to using the direction in which the resin net does not extend as the vertical fixing portion 19. An independent optical fiber fixture (base 1 and lid 7) is inserted directly into the net of the net and used. At that time, the distance between the meshes in the non-stretching direction to be inserted should be 2 or 3 cm.

  FIG. 19 shows a state where FIG.

  As described above in detail, according to the present invention, it is possible to realize a biological light measurement probe capable of measuring light measurement and electroencephalogram measurement stably and safely.

(A) Bird's-eye view, (b) Bird's-eye view seen from above, (c) Perspective view seen from the side, and (d) Seen from the side. Sectional view. (A) bird's-eye view, (b) bird's-eye view, (c) view from the side, and (d) view from the side, of the lid of the fixture for the biological optical measurement probe according to one embodiment of the present invention. Sectional view. The cross section and overhead view of the electroencephalogram electrode used for one Example of this invention. The image figure of the state which inserted the optical fiber and the electroencephalogram electrode in the fixture of the probe for biological light measurement which becomes one Example of this invention. Sectional drawing of the state which inserted the optical fiber in the fixture of the probe for biological light measurement which becomes one Example of this invention, and fitted the electroencephalogram electrode. Sectional drawing of the state which inserted the optical fiber in the fixing tool of the probe for biological light measurement which becomes one Example of this invention, and fitted the electroencephalogram electrode of the state which bent the handle | pattern. FIG. 2 is a view showing a pattern different from that in FIG. 1 in the notches in the bottom of the fixture for measuring a biological light according to an embodiment of the present invention, wherein (a) is two patterns different from FIG. There are three, (c) has four, (d) and (e) have one pattern, each with a different direction. Sectional drawing and bird's-eye view of the fixing | fixed part of the probe for biological light measurement which becomes one Example of this invention. Sectional drawing and bird's-eye view of the filling member of the probe for biological light measurement which becomes one Example of this invention. Sectional drawing of the state which inserted the optical fiber in the fixture of the probe for biological light measurement which becomes one Example of this invention, and fitted the filling member. In the probe according to the present invention, (a) a state in which the base portion of the embodiment using the stretchable material is bonded to the cap of the stretchable material, and (b) an image diagram showing a state in which the connecting member is further attached. The figure which shows a mode that the test subject mounted | wore the probe of FIG. Sectional drawing which showed the structure of the socket of the optical fiber fixing tool of the Example of FIG. 11, a ring, and a connection member. The image figure of the Example using the resin net material of the probe by this invention. The figure which shows a mode that the test subject mounted | wore the probe of FIG. The image figure of another Example using the resin net material of the probe by this invention. The figure which shows a mode that the test subject mounted | worn with the probe of FIG. The image figure of further another Example using the resin net material of the probe by this invention. The figure which shows a mode that the test subject mounted | wore the probe of FIG.

Explanation of symbols

  1: base of optical fiber fixture, 1-2: constriction of optical fiber fixture, 2: bottom of optical fiber fixture, 3: optical fiber insertion port, 4: optical fiber port, 5: notch, 6: depression 7: Cover part of optical fiber fixture, 8: Optical fiber holding part, 9: Insertion part, 10: Electroencephalogram electrode, 11: Electrode hole, 12: Electrode handle, 13: Cable, 14: Optical fiber, 15 -1: optical fiber tip, 15-2: optical fiber support, 16: filling member, 17: hole in the filling member, 18-1: center line 1, 18-2: center line 2, 19: vertical fixing part , 20: Ring, 20-1: Parts for fitting and fixing the ring 13 and the ring of the connecting member 3, 21: Cap of elastic material, 22: Connecting member, 23: Subject, 24: Resin net (Netron).

Claims (11)

  One or a plurality of irradiation optical fibers for irradiating the subject with light, and one or a plurality of detection optical fibers for detecting the light irradiated from the irradiation optical fiber and propagated through the inside of the subject And a biological light measurement probe having a plurality of optical fiber fixtures for fixing the irradiation optical fiber and the detection optical fiber, respectively, using an electroencephalogram electrode having a hole in the center The optical fiber for irradiation or detection is disposed so as to pass through the hole of the electrode.   2. The biological light measurement probe according to claim 1, wherein the bottom surface of the fixture on the side in contact with the skin has a recess recessed in the shape of the electroencephalogram electrode. 3. The biological light measurement probe according to claim 1, wherein the irradiation or detection optical fiber fixed to the fixture is disposed so as to be substantially coaxial with the hole of the electroencephalogram electrode. Probe for measuring biological light. 4. The biological light measurement probe according to claim 1, wherein the bottom surface of the fixture that is in contact with the skin and the bottom surface of the electroencephalogram electrode fitted in the recess are substantially the same height. Probe. 4. The biological optical measurement probe according to claim 1, wherein a tip of the irradiation or detection optical fiber is arranged to be substantially the same height or slightly protruding from a skin side bottom surface of the fixture or a bottom surface of an electroencephalogram electrode. A probe for measuring biological light. 6. The biological optical measurement probe according to claim 5, wherein the length of the tip of the irradiation or detection optical fiber protruding from the skin-side bottom surface of the fixture or the bottom surface of the electroencephalogram electrode ranges from 0 to about 1 millimeter. A probe for measuring biological light. 7. The biological optical measurement probe according to claim 1, wherein when the electroencephalogram electrode is not used, the depression is filled with an embedding member having substantially the same shape as the electroencephalogram electrode, and the surface in contact with the skin is substantially flattened. Probe for measuring biological light. 8. The biological optical measurement probe according to claim 1, wherein a part of one or a plurality of electroencephalogram electrodes or a notch for passing an electrode cable is formed at an edge of the bottom surface of the fixture in contact with the skin. There is a probe for measuring biological light. 9. The biological optical measurement probe according to claim 8, wherein an angle formed between a substantially center of the notch for passing the cable of the electrode and a center line of the optical fiber drawn from the fixture is between 11.5 degrees and 180 degrees. A probe for measuring biological light, which is a value. The biological light measurement probe according to claim 1, wherein the fixture and the filling member are formed of a soft material such as rubber or gel. A biological light measurement apparatus comprising the biological light measurement probe according to claim 1.

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