JP2009233793A - Needle-like article, and method of and device for manufacturing replicative needle-like article - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method of manufacturing a needle-like article so shaped as to suppress breakage during the transfer molding. <P>SOLUTION: This method of manufacturing the needle-like article uses a grinding edge having tilted surfaces between the end surface and the side surfaces, respectively, in the cross section of the grinding edge and also having a working surface formed of at least two or more types of abrasive grain surfaces. By using the method, the end area of the needle-like article where breakage is liable to occur during the transfer molding can be worked in such a surface that has extremely small surface roughness. Since working conditions can be set for the other areas without being restricted by abrasive grain size, the rupture of a substrate which occur due to the insufficient grinding capacity can be suppressed. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a fine needle-like device that can transmit a pharmaceutical product.

  The percutaneous absorption method, which is a method of infiltrating a drug from the skin and administering the drug into the body, is used as a method that can be easily administered without causing pain to the human body. There are drugs that are difficult to administer by transdermal absorption. As a method of efficiently absorbing these drugs into the body, a method of perforating the skin using micron-order fine needles and administering the drug directly into the skin has attracted attention. According to this method, it is possible to easily administer a drug subcutaneously without using a special medication device (see Patent Document 1).

  The shape of the fine needle-like body used at this time is required to have a sufficient fineness and tip angle for piercing the skin and a sufficient length for allowing the drug solution to penetrate subcutaneously, The diameter should be several μm to several hundred μm, and the length should be a length that penetrates the stratum corneum, which is the outermost layer of the skin, and does not reach the nerve layer, specifically several tens μm to several hundred μm. Is preferred.

  More specifically, it is required to penetrate the stratum corneum that is the outermost skin layer. The thickness of the stratum corneum varies slightly depending on the site, but is about 20 μm on average. In addition, an epidermis having a thickness of about 200 μm to 350 μm exists under the stratum corneum, and further, a dermis layer in which capillaries are stretched exists under the epidermis. For this reason, in order to penetrate the stratum corneum and allow the chemical solution to penetrate, a needle of at least 20 μm or more is required. Further, when producing a needle-like body for the purpose of blood collection, a needle-like body having a height of at least 350 μm or more is required due to the above-described skin structure.

  In addition, as a material constituting the needle-shaped body, even if a damaged needle-shaped body remains in the body, it is necessary to be a material that does not adversely affect the human body, such as medical silicone, Biocompatible resins such as maltose, polylactic acid, dextran, and polycarbonate are considered promising (see Patent Document 2).

  As an example of a method for producing a fine needle-like body, a technique for producing a mold original plate using precision machining and etching technology has been proposed (see Patent Document 3).

  Further, as a method for producing a biocompatible needle-like body, a method has been proposed in which a duplicate plate is raised from a mold and transfer molding is performed using the duplicate plate. (See Patent Document 4).

The known literature is described below.
US Pat. No. 6,183,434 Japanese Patent Laid-Open No. 2005-21677 JP 2002-79499 A JP-T-2007-523771

In order to produce needle-like bodies having such a fine structure at low cost and in large quantities, transfer molding methods represented by injection molding, imprinting, and casting are effective. In order to perform the molding, an original mold having a desired shape with the concavities and convexities reversed is necessary.
However, when an original mold is produced using machining or the like, the processed surface has a large surface roughness. When transfer molding is performed using such an original mold, a phenomenon may occur in which the duplicate plate and the molded product stick. Therefore, in particular, in the region of the tip of the needle-like body that is relatively fragile in terms of strength, there also arises a problem that a phenomenon that the tip is lost at the time of peeling occurs.
In addition, when a grinding blade composed only of fine abrasive grains is used to reduce the surface roughness in grinding, the grinding load decreases and the processing load increases, and the base material as a processing material is reduced. There is a problem of being damaged.

  Accordingly, the present invention has been made to solve the above-described problems, and a needle-like body and a replication needle that can suppress defects during grinding and transfer molding of a needle-like body having a fine structure. An object of the present invention is to provide a method for manufacturing a needle-like body and a device for manufacturing a needle-like body.

  In accordance with the above object, the invention according to claim 1 of the present invention is a method of manufacturing a fine needle-like body by precision machining using a grinding blade, wherein the processing surface shape of the grinding blade is the tip surface and A method of manufacturing a needle-like body, characterized in that an inclined surface is formed between the side wall surface and a grinding blade having a processing surface constituted by at least two types of abrasive grain surfaces is used. .

  The invention according to claim 2 of the present invention is characterized in that a replica is produced by transfer molding from a replica plate for mold making obtained by inverting a needle-like body produced using the production method according to claim 1. It is a manufacturing method of the duplication needlelike object which makes.

  The invention according to claim 3 of the present invention is characterized in that a biocompatible material is used as a constituent material of the replicated needle-shaped body that is replicated and manufactured by the transfer molding. It is.

  The invention according to claim 4 of the present invention is an apparatus for manufacturing a fine needle-like body using a grinding blade, and the processing surface shape of the grinding blade is formed with an inclined surface between a tip surface and a side wall surface. The needle-shaped body manufacturing apparatus is characterized by using a grinding blade having a processed surface constituted by at least two types of abrasive grain surfaces.

  The invention according to claim 5 of the present invention is the needle-shaped body manufacturing apparatus according to claim 4, wherein the abrasive grain size of the grinding blade differs depending on the inner region and the outer region of the grinding blade, and as it goes outward. An apparatus for manufacturing a needle-like body using a grinding blade characterized by an increase in particle size.

The method for producing a needle-like body of the present invention is such that an inclined surface is formed between the tip surface and the side wall surface in the processed surface shape of the grinding blade, and is constituted by at least two types of abrasive grain surfaces. A grinding blade having a processed surface is used.
By using the manufacturing method of the present invention, it is possible to process only the tip region of the needle-like body that is prone to defects during transfer molding into a surface shape with extremely small surface roughness, thus suppressing defects during transfer molding. Is possible. In addition, since the other region can be set with a grinding blade for processing and its use conditions without being restricted by the type of the abrasive grain surface for reducing the surface roughness, In manufacturing, the grinding ability is not lowered, and therefore the machining load is not increased, and as a result, breakage of the work material can be suppressed.

In addition, the method for producing a replica needle-shaped body according to the present invention is to make a replica plate for mold making from an original mold of the needle-shaped body manufactured using the grinding blade, and further perform transfer molding from the replica plate. To produce a duplicate needle like the original mold. In the transfer molding method, by selecting the filling material, it is possible to form even a material in which it is difficult to produce a needle-like body using mechanical or chemical direct processing, and a large amount of products can be formed. It is possible to manufacture efficiently and at low cost. In addition, since a biocompatible material is used as the material for transfer molding, it is possible to manufacture a replicated needle-like body using a material having a low load on the living body. If a biocompatible material is used, even if a fine needle-like body is broken and left in the body, it has an effect that it is harmless.

  Moreover, the manufacturing apparatus of the acicular body of the present invention is such that the machining surface shape of the grinding blade used in the apparatus is formed with an inclined surface between the tip surface and the side wall surface, and at least two types of abrasive surfaces are used. By using a grinding blade having a configured working surface, it is possible to provide an apparatus capable of producing a needle-like body with few defects without reducing grinding ability. In particular, in a wheel-shaped grinding blade, the abrasive particle size of the grinding blade varies depending on the inner region and the outer region, and the particle size increases toward the outer side. The manufacturing apparatus makes it possible to increase both the grinding ability and the yield rate of needle-like bodies.

  The needle-like body and the production method of the needle-like body and the needle-like body manufacturing apparatus of the present invention can be applied not only to medical treatment but also to various fields that require fine needle-like bodies. It is also useful as a fine needle-like body used for measurement jigs, drug discovery, cosmetics, biomaterials, and the like, as well as a method for producing a replicated needle-like body and a needle-like body production apparatus.

  Hereinafter, embodiments of the needle-shaped body, the method for manufacturing a replica needle-shaped body, and the apparatus for manufacturing the needle-shaped body according to the present invention will be described.

  Grinding in the present invention is precision machining with a grinding blade attached to the tip of a spindle that rotates at high speed, and finely cuts a kerf on a workpiece substrate. A grinding blade is formed in the outer peripheral part of a disk shaped support body. As a material of the grinding blade, it is desirable to have a high hardness, and diamond is generally used in many cases. In the present invention, it is also possible to use a diamond wheel in which a grinding blade made of diamond is formed on the entire outer periphery of a disc-shaped support. Diamond wheels are widely used in the cutting process of substrates in the semiconductor industry, and are inexpensive and readily available members.

FIG. 1 shows a partial cross-sectional view of the tip of the grinding blade. FIG. 1A shows a conventional example. In general, the cross-sectional shape of the grinding blade 12 is such that the grinding blade side wall surface 4 and the grinding blade tip surface 5 intersect at an angle of 90 ° to form an orthogonal vertex 6. .
On the other hand, the processing surface of the grinding blade 11 used in the method for manufacturing a needle-shaped body of the present invention has an inclined surface 7 between the tip surface 5 and the side wall surface 4 as shown in the sectional view of FIG. At this time, the inclination angle of the inclined surface 7 determines the side wall angle of the needle-like body finally formed. Thereby, the side wall angle of the acicular body manufactured can be controlled by the inclined surface of the grinding blade.

  The grinding blade of the present invention comprises at least two types of abrasive grain surfaces, for example, the abrasive grain surface A9 and the abrasive grain surface B10 (FIG. 1 (c)). At this time, the abrasive condition is not particularly limited, and an arbitrary parameter can be appropriately selected. Preferably, the abrasive grain surface A9 constituting the inner region of the grinding blade can be processed in a fine shape. Emphasis is placed on the structure, and the abrasive grain surface B10 constituting the outer region places importance on the abrasive grain structure having a high grinding ability. In the abrasive grain surface, parameters contributing to fine processing and grinding ability include material, abrasive grain size, degree of concentration, bonding conditions, and the like, and these may be arbitrarily combined to constitute a required grinding blade. More preferably, the selection of the abrasive grain size is the most effective among the parameters contributing to the fine processing and grinding ability. Specifically, the abrasive particle size is changed between the inner and outer regions of the grinding blade, and a small particle size suitable for micromachining is used on the inner side, and the particle size is increased toward the outer side to increase the grinding ability. To emphasize. Moreover, it is not limited only to such an abrasive grain surface having a regular change in one direction, and the structure of the abrasive grain surface includes an irregularly changing shape, such as a structure in which different abrasive grain surfaces are randomly arranged. There may be.

  Further, it is desirable that the processing surface shape of the grinding blade 11 is a chamfered surface 8 by chamfering so that the tip surface 5 and the inclined surface 7 of the grinding blade do not intersect with each other (see FIG. 1 (b)). At this time, the chamfered surface 8 determines the shape of the base portion of the needle-like body that is finally formed. That is, by providing the chamfered surface 8, a needle-like body having a gentle hem shape at the base can be manufactured. As a result, it is possible to relieve stress concentrated on the base of the needle-like body at the time of puncturing, and as a result, it is possible to manufacture a needle-like body having a shape suitable for suppressing breakage of the needle-like body at the time of puncturing.

  Although the processing method of a grinding blade front-end | tip part is not restrict | limited in particular, Polishing with a grindstone can be used suitably. Moreover, the manufacturing apparatus of the acicular body using said grinding blade can be utilized favorably for manufacture of an acicular body.

  Hereinafter, as an example of the method for producing a needle-shaped body in the present invention, description will be given with reference to the drawings. In the present invention, the needle-like body and the duplicate needle-like body are produced by a technique that includes a step of producing an original mold, a step of producing a duplicate plate, and a step of transfer molding from the duplicate plate.

First, as shown in FIG. 2A, a base material 1 is prepared.
At this time, the material is not particularly limited as the base material, and it is desirable to select the material from the viewpoint of processing suitability and the availability of the material. Specific examples include ceramics such as alumina, aluminum nitride, machinable ceramics, crystal materials such as silicon and quartz, organic materials such as acrylic and polyacetal, and glass.

Next, as shown in FIG. 2B, the surface of the substrate 1 is ground while rotating the grinding blade 11 to form the groove A in a linear shape by a predetermined length.
At this time, the groove A is not limited to being formed in a straight line, and may be formed in a curved line. When the groove A is provided in a curved shape, a needle-like body having a polygonal shape whose bottom surface is closed by a curved line can be manufactured.
Further, the grinding conditions such as the number of revolutions of the grinding blade and the grinding speed are not particularly limited, and it is desirable to optimize to the conditions excellent in workability in consideration of the materials of the grinding blade 11 and the substrate 1.

  By the grinding process, a groove A21 is formed as shown in FIG. The inclination of the side wall surface of the groove A21 matches the inclination of the inclined surface 7 formed at the tip of the grinding blade 11 shown in FIG. Similarly, the portion where the side wall surface and the bottom surface of the groove A21 intersect has a shape corresponding to the chamfered surface 8 formed at the tip of the grinding blade 11 shown in FIG.

Next, a step of forming at least one groove A ′ so as to be parallel to the groove A described above is performed.
As shown in FIG. 2D, the groove A′22 is processed by the grinding blade 11 next to the groove A21. At this time, it is desirable that the grinding blade 11 process the groove so as to partially overlap the groove A21. As a result, the tip of the convex portion formed by grinding does not become flat, can be sharpened, and a needle-like body having excellent puncture properties can be manufactured.
The groove A ′ is ground in parallel with the groove A21.
As a result, a groove A′22 as shown in FIG. Between the groove A21 and the groove A′22, the tip end portion is overlapped by the overlapping of the inclined surface 7 of the grinding blade 11 when forming the groove A and the inclined surface 7 of the grinding blade 11 when forming the groove A ′. Since the apex is formed, the convex portion 2 having a sharp tip shape is formed. Therefore, when a plurality of grooves A ′ are provided, it is necessary to form the grooves A ′ so as to be adjacent to the already provided grooves.

  The height of the convex portion 2 is determined by the grinding depth, the angle of the inclined surface 7 of the grinding blade 11, and the overlapping distance between the groove A21 and the groove A'22.

Next, grooves are sequentially formed in the same manner as the groove A′22 is formed, and as shown in FIG. 2 (f), a desired number of convex portions 2 are formed to have a substantially triangular cross-sectional shape. The base material 3 having the convex portions 2 formed on the surface is obtained.
At this time, the number of needle-like bodies arranged in an array to be manufactured is determined by the number of convex portions 2 to be formed.
As shown in FIG. 3, the cross-sectional shape of the convex portion 2 has a side wall inclination that matches the inclination of the inclined surface 7 formed at the tip of the grinding blade 11, and the portion where the side wall surface and the bottom surface intersect is shown in FIG. 2. 11 is a shape 13 having a skirt corresponding to the chamfered surface 8 formed at the tip of 11.
Also, the needle-like body can be formed in various side shapes depending on the shape of the grinding surface used. Although FIG. 3 shows an example of a needle-like body having two types of surface states, it is not limited to this. As a result, it is possible to produce a needle-like body without changing the grinding conditions on the bottom surface by performing fine processing only on the tip portion where defects are likely to occur during transfer. Alternatively, it is possible to change only the surface roughness of the bottom surface while maintaining the conventional condition of the tip, which is the opposite, and an arbitrary shape according to the design can be produced.
In addition, the transition of the grinding surface can be processed stepwise or continuously, and this is also determined by the shape of the grinding blade used. Depending on the shape of the grinding blade, several types of repetitive patterns can be reproduced on the side surface of the needle-like body.

  In FIG. 3, the example in which the portion where the side wall surface and the bottom surface intersect with each other in the cross-sectional shape of the convex portion 2 has an arcuate hem shape, but the angle intersects with an angle smaller than the angle between the side wall surface and the bottom surface. By forming at least one auxiliary plane, it is possible to relieve the stress concentrated on the needle base at the time of puncturing. In this case, at the time of tip processing of the grinding blade 11, a grinding blade having at least one auxiliary plane is used so as to chamfer the apex portion formed by the inclined surface 7 and the grinding blade tip surface 5 intersecting.

  Next, a cross groove B is provided so as to cross the groove A, and a cross groove B ′ is provided so as to be parallel to the cross groove B. At this time, the groove A21 and the groove A′22 are provided, and the substrate 3 on which the convex portion is formed is rotated, so that the intersection groove B and the intersection groove are equivalent to the condition where the groove A21 and the groove A′22 are provided. B ′ can be formed. In the case described above, the intersecting angle between the groove A and the groove A ′ and the intersecting groove B and the intersecting groove B ′ is equal to the rotation angle of the base material 3 having the convex portions formed on the surface.

  FIG. 4 is a perspective view showing an example in which the base material 3 having the convex portions 2 formed on the surface is rotated by 90 ° and grinding is performed under the same conditions as the groove forming step. In this case, as shown in FIG. 4, the portion that remains without being ground becomes an array-like regular pyramid 24, and an array-like needle-like body 25 is obtained on the support substrate 23. In FIG. 4, the regular quadrangular pyramid 24 and the support substrate 23 are connected at an angle, but by using the grinding blade 11 subjected to the chamfering described above, the base of the pyramid has a gentle hem shape. I can do it. Further, the groove slope has a surface roughness distribution depending on the particle size of the selected grinding blade.

Further, the step of providing the intersecting groove B and the intersecting groove B ′ parallel to the intersecting groove may be performed a plurality of times. By controlling the number of executions of the process and the angle at which the grooves intersect, cone-shaped needles having various bottom shapes can be manufactured.
For example, when the process of providing the intersection groove B and the intersection groove B ′ parallel to the intersection groove is performed once and the two-direction grinding is performed by shifting by 60 °, a quadrangular pyramid shape having a rhombus at the bottom is obtained. At this time, the apex angle of the rhombus is 60 ° and 120 ° at the opposite apexes.
Further, by performing the process of providing the intersecting groove and the intersecting groove ′ parallel to the intersecting groove twice and grinding in three directions, a needle-like body having a hexagonal pyramid shape on the bottom surface can be obtained.

Moreover, the convex part which is not a needle-like body may remain in the periphery of the needle-like body group obtained by said process depending on the case. When it is necessary to remove this, the convex portion may be removed by grinding.

  From the above, by controlling the cross-sectional shape of the grinding blade, the number of executions of the process, and the angle at which the grooves intersect, a conical needle-like body having an arbitrary surface shape and an arbitrary polygonal bottom is manufactured. I can do it. In addition, since the needle-like bodies can be created for each column by providing the linear grooves, it is possible to form the needle-like bodies in a lump, particularly when manufacturing the needle-like bodies arranged in an array. . The needle-like body obtained so far can be used as an original mold for duplication described below.

  Next, a method for manufacturing a duplicate plate from an original mold (see FIGS. 5A and 5B) will be described with reference to the drawings. In FIG. 5A, the replica material 31 is filled in the original mold 30. At this time, an additive or the like may be added. After the replication material is cured, as shown in FIG. 5B, the replication material 31 is peeled from the original mold 30 to form a concave replication plate 33. By producing a duplicate plate, a large amount of needles can be produced from the same duplicate plate, so that production costs can be suppressed and productivity can be increased.

  The original mold used here may be subjected to surface shape processing and chemical surface modification before transfer in order to improve the releasability of the duplicated plate. Specifically, polishing by machining, drilling, grooving, surface processing and surface modification using an etching process, or application of a release agent can be preferably used. Further, at the time of producing a duplicate plate, heating and cooling may be performed to control the curing rate.

  Further, in the duplicate plate production process, it is preferable to perform a defoaming process in order to improve reproducibility in a fine region. A known defoaming method may be used for the defoaming step. For example, it can be performed using a defoaming method such as vacuum defoaming, centrifugal defoaming, stirring defoaming or the like.

  The replication material is not particularly limited, and a material can be selected in consideration of the shape followability capable of transferring the original plate, transferability in transfer processing molding described later, durability, and releasability. For example, it can be produced by a technique using nickel or a silicone resin material, and can be suitably used as an inexpensive and low-risk material. However, it is not limited to this. Examples of a replication method when nickel is selected include a plating method and a PVD method. Further, a purification step may be added to remove impurities in the replication material.

  When producing a duplicate plate, it is possible to provide a function such as control of curing time by adding an arbitrary additive to the resin duplicate material. The additive used here is not particularly limited, and a material that does not cause harmful effects by reaction with the replication material may be selectively used. Examples of the materials used include inorganic materials, water, and organic solvents, but other materials that can affect the formation of the replica plate surface shape may be used, and the present invention is not limited thereto. The timing at which the additive is added is not particularly limited, and can be added before the replica material is cured before filling. Preferably, it is before filling, which can promote uniform dispersion of the additive. Moreover, the additive used is not limited to only one type, and a plurality of different types of additives may be used. Moreover, in order to make the addition amount into arbitrary surface shapes, the addition and subtraction can be changed as appropriate. In order to completely remove the additive, a duplicate plate washing step may be added after the duplicate plate is cured.

  At this time, the viscosity of the replication material before mixing with the additive is preferably 1 Pa · s to 100 Pa · s. If the viscosity is too low, the additive cannot be fixed in the replication material, resulting in two layers. On the other hand, if the viscosity is too high, the additive cannot be evenly dispersed in the replication material and will exist as a lump.

  Next, transfer processing molding using a duplicate plate (see FIGS. 5C and 5D) will be described. In FIG. 5 (c), the duplication plate 33 is filled with a molding material 34. The molding material is not particularly limited, but it is preferable to use a medical silicone resin, maltose, polylactic acid, dextran, saccharide, polycarbonate, or the like, which is a biocompatible material, in a duplicate needle-like body that becomes a puncture part. If a biocompatible material is used, even if the needle-shaped body is broken and left in the body, it has an effect that it is harmless. Although there is no restriction | limiting about the filling method of the molding material 34 at this time, From a viewpoint of productivity, the imprint method, the hot embossing method, the injection molding method, the extrusion molding method, and the casting method can be used suitably.

  After filling with the molding material 34, it is peeled off from the duplicate plate 33 to obtain an arbitrary duplicate needle 35. At this time, in order to improve the peelability of the duplicate plate, a release layer for increasing the mold release effect may be formed on the surface of the duplicate plate before filling the material of the duplicate needle-like body (not shown). ) As the release layer, for example, a widely known fluorine-based resin can be used. Moreover, as a formation method of a mold release layer, thin film formation methods, such as PVD method, CVD method, a spin coat method, a dip coat method, can be used suitably.

  From the above, it is possible to carry out the production of the needle-shaped body and the duplicate needle-shaped body of the present invention. In addition, the manufacturing method of the acicular body of this invention and a replication acicular body is not limited to the said embodiment, The other well-known method which can be guessed in each process shall also be included.

  Hereinafter, the method for producing the needle-shaped body of the present invention will be described with specific examples. Naturally, the manufacturing method of the acicular body of the present invention is not limited to the following examples, and includes other manufacturing methods that can be inferred from known materials in each step.

First, the tip of a grinding blade containing diamond abrasive grains was processed into a desired shape, which will be described later, by polishing with a diamond grindstone.
FIG. 1 is a partial cross-sectional view of the tip of a disc-shaped grinding blade. As shown in FIG. 1A, the cross-sectional shape of the grinding blade 12 before polishing is such that the grinding blade side wall surface 4 and the grinding blade tip surface 5 intersect at an angle of 90 ° to form a vertex 6.
The grinding blade 12 was processed using a diamond grindstone to obtain a grinding blade 11.
As shown in FIG. 1 (b), the grinding blade 11 has an inclined surface 7, and the apex portion formed by the intersection of the inclined surface 7 and the grinding blade tip surface 5 is processed into a shape having an approximate chamfered surface 8.
In this embodiment, a grinding blade having a thickness of 1 mm is used, the tip of the grinding blade is polished to have a width of 200 μm, and the angle between the side surface 4 of the grinding blade and the inclined surface 7 is 160 °. processed.
The inclination angle of the inclined surface 7 determines the side wall angle of the needle-like body finally formed. Further, the chamfered surface 8 determines the shape of the base portion of the needle-like body that is finally formed. In order to set the tip angle of the finally formed pyramid shaped needle-like body to 40 °, the inclination of the inclined surface 7 of the tip of the grinding blade in this example was selected to be 160 °.
At this time, the structure of the grinding blade was composed of two types of abrasive grain surfaces as shown in FIG. The outer peripheral region of the grinding blade is composed of diamond abrasive grains having an average abrasive grain size of about 50 μm, and the inside thereof is composed of diamond abrasive grains having an average grain size of about 20 μm.

Next, the process of forming the groove | channel A in the surface of the ceramic base material was implemented by the grinding process by the grinding blade which processed the front-end | tip as above-mentioned.
First, as shown in FIG. 2A, a ceramic substrate having a square of 30 mm on a side and a thickness of 3 mm is prepared. Subsequently, as shown in FIG. 2B, the surface of the ceramic substrate is rotated while rotating the grinding blade. Was ground to a depth of 300 μm to form a groove having a length of 30 mm.

By the grinding process, a groove A was formed as shown in FIG. The width of the upper opening of the groove A was about 418 μm and the depth was 300 μm.
The inclination of the side wall surface of the groove A corresponds to the inclination of the inclined surface formed at the tip of the grinding blade. In this example, the angle formed by the surface of the ceramic substrate and the side wall surface of the groove A was 110 °. . Similarly, the portion where the side wall surface and the bottom surface of the groove A intersect each other has a shape having a skirt corresponding to the chamfered surface formed at the tip of the grinding blade.

Next, the process of processing groove | channel A 'to the surface of the base material 1 was implemented.
As shown in FIG. 2D, a groove was machined by a grinding blade adjacent to the groove A under the same conditions as the groove A. At this time, the grinding blade worked the groove so as to overlap the groove A by a width of 100 μm. Moreover, it grind | polished in parallel with respect to the groove | channel A. Thus, a groove A ′ having a depth of 300 μm and a length of 3 mm was formed adjacent to the groove A as shown in FIG. A convex portion having a sharp tip shape was formed between the groove A and the groove A ′.

  The height of the convex portion 2 is determined by the grinding depth, the angle of the tip inclined surface of the grinding blade, and the overlapping distance between the groove A and the groove A ′. In the present example, the height of the convex portion 2 was about 162 μm, and the width of the root was about 118 μm. The tip of the convex portion formed by the overlapping of the inclined surfaces at the tip of the grinding blade became the apex at an angle of 40 °.

  Next, the grooves are sequentially formed in the same manner as the groove A ′, and as shown in FIG. 2 (f), a desired number of protrusions are formed, and the protrusions have a generally triangular cross-sectional shape. A base material having a surface formed thereon was obtained. In this example, a total of 6 grooves were produced. Five protrusions were formed by forming six grooves. As shown in FIG. 3, the cross-sectional shape of the convex portion has a side wall inclination that matches the inclination of the inclined surface formed at the tip of the grinding blade, and the portion where the side wall surface and the bottom surface intersect with each other at the tip of the grinding blade in FIG. It became a shape with a hem corresponding to the formed chamfered surface.

  Next, the base material on which the five convex portions formed by the previous six groove forming steps were formed was rotated by 90 °, and grinding was performed under the same conditions as in the groove forming step. As a result, five intersecting grooves B and five intersecting grooves B ′ are formed. As a result, the portion that remains without being ground becomes an array of regular quadrangular pyramids as shown in FIG. A needle-like body was obtained. In this example, 25 needle-like bodies arranged in an array of 5 columns and 5 rows were obtained. The needle-like body obtained at this time was a quadrangular pyramid, the tip angle was 40 °, the height was about 162 μm, and the width of one side of the bottom surface was 118 μm. Moreover, the boundary line produced by the difference in surface roughness was confirmed on the side surface of the pyramid, and the tip portion became a needle-like body having a structure in which the surface roughness was reduced compared to the base portion.

Next, in order to replicate the produced needle-like body, the produced needle-like body was used as a mother die, a duplicate plate was made from the mother die, and a transfer processing molding process was performed.
First, a nickel film of 600 μm was formed on the surface of the needle-like body by a plating method. Next, the nickel film was peeled off from the acicular body to produce a duplicate plate. Next, a replica needle was produced using the imprint method for the duplicate plate. Polycarbonate, which is a biocompatible material, was used as the replica needle material to be filled. Through the above steps, a sharp replica needle-like body made of polycarbonate, which is a biocompatible resin, could be manufactured.

  The replica needle-like body of the present invention can be expected to be used as a fine needle used in a device for transporting drugs such as medicines, drug discovery, and cosmetics.

It is a partial schematic sectional drawing which shows an example of the cross-sectional structure of the front-end | tip part of the grinding blade used with the manufacturing process and manufacturing apparatus of an acicular body. (A) is a conventional grinding blade, (b) and (c) are grinding blades of the present invention. (A)-(f) is a schematic sectional drawing for demonstrating the manufacturing process of the acicular body by embodiment of the manufacturing method of the acicular body of this invention with time. It is a partial schematic sectional drawing which shows an example of the cross-sectional structure of the acicular body in the manufacturing method of the acicular body of this invention. It is a schematic perspective view for demonstrating the collection of the acicular body manufactured by the manufacturing method of the acicular body of this invention. (A)-(d) is a sectional side view of an example of the general | schematic process for demonstrating the manufacturing process of the replication acicular body of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Base material 2 ... Convex part 3 ... Base material 4 in which convex part was formed on the surface ... Grinding blade side wall surface 5 ... Grinding blade tip surface 6 ... Orthogonal vertex 7 of grinding blade tip part ... Inclined surface 8 ... Chamfering surface 9 ... Abrasive surface A
10: Abrasive surface B
DESCRIPTION OF SYMBOLS 11 ... Grinding blade front-end | tip part cross-section 12 which processed the front-end | tip ... Conventional grinding blade front-end | tip part cross-section 13 ... The gentle skirt-shaped part 21 of a needle-like body base part ... Groove A
22 ... Groove A '
23 ... the support substrate of the needle-like body,
24 ... acicular body,
25 ... Needle-like bodies 30 arranged in an array form ... Original mold needle-like bodies 31 ... Duplicating material 33 ... Duplicating plate 34 ... Molding material 35 ... Duplicating needle-like bodies

Claims (5)

A method for producing a fine needle-like body by precision machining using a grinding blade,
As for the processing surface shape of the grinding blade, an inclined surface is formed between the tip surface and the side wall surface, and a grinding blade having a processing surface composed of at least two types of abrasive surfaces is used. A method for producing a needle-like body characterized by the above.   A method for producing a duplicate needle-like body, wherein a replica plate for mold making produced by inverting the needle-like body produced using the production method according to claim 1 is produced by transfer molding.   The method for producing a duplicate needle-like body according to claim 2, wherein a biocompatible material is used as a constituent material of the duplicate needle-like body produced by replication by the transfer molding. An apparatus for producing a fine needle-like body using a grinding blade,
As for the processing surface shape of the grinding blade, an inclined surface is formed between the tip surface and the side wall surface, and a grinding blade having a processing surface composed of at least two types of abrasive surfaces is used. The needle-shaped body manufacturing apparatus characterized by the above. The needle-shaped body manufacturing apparatus according to claim 4,
An apparatus for producing a needle-like body using a grinding blade, wherein the grinding particle size of the grinding blade varies depending on an inner region and an outer region of the grinding blade, and the particle size increases toward the outer side.