JP2009203220A - Substituted isoxazoline compound and pest control agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new pest control agent, especially an insecticide or a miticide. <P>SOLUTION: A substituted isoxazoline compound represented by general formula (1) [wherein A<SP>1</SP>, A<SP>2</SP>, A<SP>3</SP>and A<SP>4</SP>represent each independently C-Y or N; G represents a benzene ring or the like; L represents -CH(R<SP>4</SP>)- or the like; X represents a hydrogen atom or the like; R<SP>1</SP>represents -C(O)R<SP>1a</SP>or the like; R<SP>1a</SP>represents a 1-2C alkyl or the like, substituted with a 1-4C alkyl or the like; R<SP>2</SP>represents a hydrogen atom or a 1-2C alkyl or the like, substituted with a 1-4C alkyl or the like; R<SP>3</SP>represents trifluoromethyl, chlorodifluoromethyl or the like] or a salt thereof, and a pest control agent containing such a compound or salt, are provided. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a novel substituted isoxazoline compound and a salt thereof, and a pest control agent comprising the compound as an active ingredient. The pest control agent in the present invention refers to the fields of agriculture and horticulture or livestock / hygiene (internal or external parasites for animals or birds as domestic animals or pets, hygiene pests and unpleasant pests at home and work sites), etc. It means a pest control agent for harmful arthropods. The agrochemical in the present invention means an insecticide / acaricide, nematicide, herbicide, fungicide, etc. in the field of agriculture and horticulture.

  Conventionally, regarding substituted isoxazoline compounds, 4- (5-substituted-5-substituted aryl-4,5-dihydroisoxazol-3-yl) benzoic acid amide compounds exhibit pest control activity, particularly insecticidal / miticidal activity. It is known (see Patent Documents 1 and 2). However, there is no disclosure regarding N- [4- (5-substituted-5-substituted aryl-4,5-dihydroisoxazol-3-yl) phenylmethyl] amide compounds and the like according to the present invention.

  In addition, 3- (5-substituted carbamoyl-5-substituted alkyl-4,5-dihydroisoxazol-3-yl) benzylamine derivatives have platelet glycoprotein IIb / IIIa fibrinogen receptor complex antagonistic activity or factor Xa inhibitory activity, etc. And is used as a thrombolytic agent and a therapeutic agent for thromboembolic diseases (see, for example, Patent Document 3 and Patent Document 4). Furthermore, it is known that another specific substituted isoxazoline compound is used as an intermediate for producing an HIV protease inhibitor or an intermediate for producing an insecticide (see, for example, Patent Document 5 and Patent Document 6). However, there is no disclosure regarding the N- [4- (5-substituted-5-substituted aryl-4,5-dihydroisoxazol-3-yl) phenylmethyl] amide compound and the like according to the present invention. The usefulness as a pest control agent is not known at all.

On the other hand, regarding substituted benzaldoxime compounds, 4- (aminomethyl) benzaldoxime and N- [4- (hydroxyiminomethyl) phenylmethyl] carbamic acid-tert-butyl (see, for example, Patent Document 7), 4 -Alkoxy-substituted benzaldoxime derivatives (see, for example, Patent Document 8) and 4-hydroxyiminomethyl-N, N-dimethylbenzoic acid amide (see Non-Patent Document 1) are known. However, the 4-[(substituted amido) alkyl] benzaldoxime derivative that can be used as an intermediate for producing the pest control agent according to the present invention is a novel compound not described in any literature.
International Publication No. 2005/085216 Pamphlet International Publication No. 2007/026965 Pamphlet International Publication No. 97/023212 Pamphlet International Publication No. 97/048395 Pamphlet WO99 / 014210 Pamphlet International Publication No. 2004/018410 Pamphlet International Publication No. 2005/116209 Pamphlet International Publication No. 95/024398 Pamphlet Journal of the Chemical Society Perkin Transactions, 1 [J. Chem. Soc. Perkin Trans. 1] 1979, p. 643

  The development of pest control agents for the purpose of controlling various pests such as agricultural and horticultural pests, forest pests, and hygiene pests has progressed, and a wide variety of drugs have been put to practical use to date.

  However, due to the long-term use of such drugs, in recent years, pests have acquired drug resistance, making it difficult to control with existing insecticides and fungicides that have been used. In addition, some existing pest control agents are highly toxic, or some of them remain in the environment for a long time, and the problem of disturbing the ecosystem is becoming apparent. Under such circumstances, development of a novel pest control agent having not only high pest control activity but also low toxicity and low persistence is always expected.

  As a result of intensive research aimed at solving the above problems, the present inventors have found that the novel substituted isoxazoline compounds represented by the following general formulas (1) and (1a) according to the present invention are excellent pests. The present invention has been completed by discovering that it is a very useful compound that exhibits control activity, particularly insecticidal / miticidal activity, and has little adverse effect on non-target organisms such as mammals, fish and beneficial insects.

  That is, the present invention relates to the following [1] to [14].

  [1] General formula (1):

[Wherein, A ¹ , A ² , A ³ and A ⁴ each independently represent CY or N;
G represents a benzene ring, a nitrogen-containing 6-membered aromatic heterocycle, a furan ring, a thiophene ring or a 5-membered aromatic heterocycle containing two or more heteroatoms selected from an oxygen atom, a sulfur atom and a nitrogen atom;
L is -C (R ⁴ ) (R ^4a )-, -C (R ⁴ ) (R ^4a ) CH _2- , -CH ₂ C (R ⁴ ) (R ^4a )-, -N (R ^4b )- Or -C (R ⁴ ) (R ^4a ) N (R ^4b )-
X is a halogen atom, cyano, nitro, _{azido, -SCN, -SF 5, C 1} ~C 6 alkyl, optionally substituted by R ⁵ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl , optionally substituted by R ⁵ (C ₃ ~C ₈₎ cycloalkyl, optionally substituted by _{E-1~E-50, C 2} ~C 6 _{^{alkenyl, R 5 (C 2 ~C 6}} ) alkenyl , C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₂ -C ₆ alkynyl, optionally substituted by R ⁵ (C ₂ ^~C ₆₎ alkynyl, -OH, -OR ^6, - OS (O) ₂ R ⁶ , -SH, -S (O) _r R ⁶ , -N (R ⁸ ) R ⁷ , -N = C (R ^8a ) R ^7a , -C (O) R ⁹ , -C (R ⁹ ) = NOH, -C (R ⁹ ) = NOR ¹⁰ , M-5, M-20, M-48, -C (O) OR ¹⁰ , -C (O) SR ¹⁰ , -C (O) N (R ¹² ) R ¹¹ , -C (S) OR ¹⁰ , -C (S) SR ¹⁰ , -C (S) N (R ¹² ) R ¹¹ , M-40 to M-43, M-46, M -47, -S (O) ₂ OR ¹⁰ , -S (O) ₂ N (R ¹² ) R ¹¹ , -Si (R ^13a ) (R ^13b ) R ¹³ , phenyl, phenyl substituted by (Z) _p1 Or D-1 to D-65 And, when m represents an integer of 2 or more, each X may be the or different from each other the same as each other,
Further, when two Xs are adjacent to each other, the two adjacent Xs are -CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ O-, -CH ₂ OCH _2- , -OCH ₂ O-, -CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -CH ₂ CH ₂ N (R ¹⁴ )-, -CH ₂ N (R ¹⁴ ) CH _2- , -CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH _2- , -CH ₂ OCH ₂ O-, -OCH ₂ CH ₂ O-, -OCH ₂ CH ₂ S-, -CH ₂ CH = CH-,- OCH = CH-, -SCH = CH-, -N (R ¹⁴ ) CH = CH-, -OCH = N-, -SCH = N-, -N (R ¹⁴ ) CH = N-, -N (R ¹⁴ By forming N = CH-, -CH = CHCH = CH-, -OCH ₂ CH = CH-, -N = CHCH = CH-, -N = CHCH = N- or -N = CHN = CH- A 5-membered ring or a 6-membered ring may be formed together with the carbon atom to which each of two Xs is bonded. At this time, the hydrogen atom bonded to each carbon atom forming the ring is optionally substituted by Z. In addition, when simultaneously substituted with two or more Z, each Z may be the same as or different from each other,
Y is a hydrogen atom, a halogen atom, cyano, nitro, _{azido, -SCN, -SF 5, C 1} ~C 6 alkyl, optionally substituted by R ⁵ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally substituted by R ⁵ (C ₃ ~C ₈₎ cycloalkyl, E-1~E-50, C 2 ~C 6 alkinyl, optionally substituted by R ⁵ (C ₂ ~C ₆₎ ^{alkynyl, -OH, -OR 6, -OS (} O) 2 R 6, -SH, -S (O) r R 6, -N (R 8) R 7, -N (R 8) C (O ) R ^9a , -N = C (R ^8a ) R ^7a , -C (O) N (R ¹² ) R ¹¹ , -C (S) N (R ¹² ) R ¹¹ , -Si (R ^13a ) (R ^13b ) R ¹³ , phenyl, (Z) phenyl substituted by _p1 or D-1 to D-65, and when two or more Y are present at the same time, each Y may be the same as or different from each other You may,
Further, when two Ys are adjacent to each other, the two adjacent Ys are —CH ₂ CH ₂ CH ₂ —, —CH ₂ CH ₂ O—, —CH ₂ OCH ₂ —, —OCH ₂ O—, —CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -SCH ₂ S-, -CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH ₂ -,- CH ₂ OCH ₂ O-, -OCH ₂ CH ₂ O-, -OCH ₂ CH ₂ S-, -SCH ₂ CH ₂ S-, -OCH = N-, -SCH = N-, -CH = CHCH = CH- , -CH = CHCH = N-, -CH = CHN = CH-, -CH = NCH = CH- or -N = CHCH = CH- to form 5 together with the carbon atom to which each of the two Y bonds. A hydrogen atom bonded to each carbon atom forming the ring may be optionally substituted by Z, and at the same time two or more Z may be formed. When substituted, each Z may be the same as or different from each other,
R ¹ is a hydrogen atom, -C (O) R ^1a , -C (O) OR ^1b , -C (O) SR ^1b , -C (O) N (R ^1d ) R ^1c , -C (S) R ^1a , -C (S) OR ^1b , -C (S) SR ^1b , -C (S) N (R ^1d ) R ^1c , -S (O) ₂ R ^1b or -S (O) ₂ N (R ^1d ) ^Represents R ^1c
R ^1a is hydrogen atom, C ₁ -C ₁₂ alkyl, optionally substituted by R ¹⁵ (C ₁ ~C ₁₂₎ alkyl, C ₃ -C ₁₂ cycloalkyl, optionally substituted by R ¹⁵ (C ₃ -C ₁₂₎ cycloalkyl, E-1~E-50, C 2 ~C 12 alkenyl, optionally substituted by R ¹⁵ (C ₂ ~C ₁₂₎ alkenyl, C ₅ -C ₁₂ cycloalkenyl, C ₅ ~ C ₁₂ halo cycloalkenyl, C ₂ -C ₁₂ alkynyl, optionally substituted by R ¹⁵ (C ₂ ~C ₁₂₎ ^{alkynyl, - [C (R 16a)} (R 16b)] n -R 16, -C ( O) R ⁹ , -C (O) R ^9a , -C (R ⁹ ) = NOH, -C (R ⁹ ) = NOR ¹⁰ , -C (R ⁹ ) = NN (R ¹² ) R ¹¹ , -C ( O) OR ¹⁰ , -C (O) N (R ¹² ) R ¹¹ , phenyl, (Z) phenyl substituted by _p1 or D-1 to D-65,
R ^1b is optionally substituted by C ₁ -C ₁₂ alkyl, optionally substituted by R ¹⁵ (C ₁ ~C ₁₂₎ alkyl, C ₃ -C ₁₂ cycloalkyl, R ¹⁵ (C ₃ ~C ₁₂ ) Cycloalkyl, E-3, E-4, E-6, E-8, E-10, E-25, E-26, E-28, E-29, E-31, E-32, E- 35, E-38, E- 42, E-46, E-49, C 2 ~C 12 alkenyl, C ₂ -C ₁₂ haloalkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, phenyl, (Z) phenyl substituted by _p1 , D-1 to D-4, D-6 to D-13, D-15 to D-23, D-25 to D-37, D-39, D-40, D-42, D-43, D-45, D-47 or D-50 to D-65,
R ^1c is a hydrogen atom, C ₁ -C ₁₂ alkyl, optionally substituted by R ¹⁵ (C ₁ ~C ₁₂₎ alkyl, C ₃ -C ₁₂ cycloalkyl, optionally substituted by R ¹⁵ (C ₃ -C ₁₂₎ cycloalkyl, E-3~E-6, E -8, E-10, E-24~E-26, E-28, E-29, E-31, E-32, E-35 , E-38, E-42 , E-46, E-49, C 2 ~C 12 alkenyl, C ₂ -C ₁₂ haloalkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, - [C (R ^16a ) (R ^16b )] _n -R ¹⁶ , -C (O) R ⁹ , -C (O) R ^9a , -C (R ⁹ ) = NOR ¹⁰ , -C (O) OR ¹⁰ , -C (O) SR ¹⁰ , -C (O) N (R ¹² ) R ¹¹ , M-11, M-28, -C (S) R ⁹ , -C (S) OR ¹⁰ , -C (S) SR ¹⁰ , -C (S) N (R ¹² ) R ¹¹ , M-14, M-32, -OR ¹⁰ , -S (O) ₂ R ¹⁰ , -S (O) ₂ N (R ¹² ) R ¹¹ ,- N (R ¹⁸ ) R ¹⁷ , phenyl, phenyl substituted by (Z) _p1 , D-1 to D-45 or D-47 to D-65,
R ^1d is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₆₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl Or R ^1d together with R ^1c forms a C ₂ -C ₆ alkylene chain, thereby forming a 3- to 7-membered ring with the nitrogen atom to which R ^1c and R ^1d are bonded. represents good, this time the alkylene chain an oxygen atom, may contain one sulfur atom or a nitrogen atom, and C ₁ -C ₆ alkyl group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, C ₁ -C ₆ alkylaminocarbonyl group, C ₁ -C ₆ halo alkylaminocarbonyl group, di (C ₁ -C ₆ alkyl) amino Carbonyl group may optionally be substituted by oxo group or thioxo group,
R ² is hydrogen atom, cyano, C ₁ -C ₁₂ alkyl, (C ₁ -C ₁₂ ) alkyl, C ₃ -C ₁₂ cycloalkyl, C ₃ -C ₁₂ alkenyl, C ₃ optionally substituted by R ^15a -C ₁₂ haloalkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ ^{haloalkynyl, -C (O) R 9,} -C (O) R 9a, -C (O) OR 10, -C (O) SR ¹⁰ , -C (O) N (R ¹² ) R ¹¹ , -C (O) C (O) OR ¹⁰ , -C (S) OR ¹⁰ , -C (S) SR ¹⁰ , -C (S) N (R ¹² ) R ¹¹ , C ₁ -C ₁₂ alkoxy, C ₁ -C ₁₂ haloalkoxy, -SR ¹⁰ , -S (O) ₂ R ¹⁰ , -SN (R ^18a ) R ^17a , phenyl, (Z) _p1 R ¹ and R ² are linked by representing phenyl substituted by D or D-52 to D-54, or R ² together with R ¹ to form a C _{4 to} C ₆ alkylene chain together with the nitrogen atom represent that may form a 5- to 7-membered ring, this time the alkylene chain an oxygen atom, may contain one sulfur atom or a nitrogen atom, and C ₁ -C ₆ alkyl group, C ₁ C ₆ alkylidene group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ haloalkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, C ₁ -C ₆ haloalkoxycarbonyl groups, C ₁ -C ₆ alkylaminocarbonyl group, C ₁ -C ₆ halo alkylaminocarbonyl group, di (C ₁ -C ₆ alkyl) aminocarbonyl group, a phenyl group, D-52 group, D-55 group, optionally by an oxo group or thioxo group May be replaced,
R ³ represents a halogen atom, cyano, optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ⁵ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ⁵ ( C ₃ -C ₈₎ cycloalkyl, E-1~E-50, C 3 ~C 6 alkenyl, optionally substituted by R ⁵ (C ₂ ~C ₆₎ alkenyl, C ₃ -C ₆ alkynyl, R ⁵ (C ₂ -C ₆ ) alkynyl, -OR ⁶ , -S (O) _r R ⁶ , -N (R ¹² ) R ¹¹ , -C (O) R ⁹ , -C (R ⁹ ) = NOH, -C (R ⁹ ) = NOR ¹⁰ , M-5, M-20, M-48, -C (O) OR ¹⁰ , -C (O) SR ¹⁰ , -C (O) N (R ^{12) R 11, -C (S} ) OR 10, -C (S) SR 10, -C (S) N (R 12) R 11, -Si (R 13a) (R 13b) R 13, -P ( O) (OR ¹⁹ ) ₂ , phenyl, (Z) phenyl substituted by _p1 or D-1 to D-65,
R ⁴ is a hydrogen atom, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, C ₁ -C _{6 alkoxycarbonyl, -C (O) NH 2,} -C (S) NH 2, phenyl, (Z) phenyl substituted by _{p1, D-1~D-4,} D-18, D-21 or D-52 ~ Represents D-54,
R ^4a represents a hydrogen atom or C ₁ -C ₆ alkyl, or R ^4a together with R ⁴ forms a C ₂ -C ₅ alkylene chain, thereby binding R ⁴ and R ^4a It indicates that may form a 3-6 membered ring with the carbon atom, this time the alkylene chain an oxygen atom, may contain one sulfur atom or a nitrogen atom, and C ₁ -C ₄ alkyl group, -CHO group, C ₁ -C ₄ alkylcarbonyl group, C ₁ -C ₄ alkoxycarbonyl group, C ₁ -C ₄ alkylaminocarbonyl group, C ₁ -C ₄ halo alkylaminocarbonyl group, di (C ₁ -C ₄ alkyl) amino Optionally substituted by a carbonyl group or a phenyl group,
R ^4b is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₃ -C ₆ cycloalkylcarbonyl, C ₃ -C ₆ halocycloalkyl carbonyl, represents C ₁ -C ₆ alkoxycarbonyl or C ₁ -C ₆ haloalkoxycarbonyl,
D-1 to D-65 each represent an aromatic heterocycle represented by the following structural formula;

Z is a halogen atom, cyano, nitro, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkoxy (C ₁ ~ C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, -OH, C ₁ ~C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ haloalkyl sulfonyloxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ Haroaruki Sulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, -NH _2, C ₁ ~C ₆ alkyl amino, di (C ₁ -C ₆ alkyl) amino, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C _{6 haloalkoxycarbonyl, -C (O) NH 2,} C 1 ~C 6 alkyl amino carbonyl, C ₁ -C ₆ haloalkylcarbonyl aminocarbonyl, di (C ₁ -C ₆ alkyl) aminocarbonyl, -C (S ) NH ₂ , —S (O) ₂ NH ₂ , C ₁ -C ₆ alkylaminosulfonyl, di (C ₁ -C ₆ alkyl) aminosulfonyl or phenyl, p1, p2, p3 or p4 is an integer of 2 or more Each Z may be the same as or different from each other;
Further, when two Zs are adjacent to each other, the two adjacent Zs are -CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ O-, -CH ₂ OCH _2- , -OCH ₂ O-, -CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -CH ₂ CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH _2- , -CH ₂ OCH ₂ O- , -OCH ₂ CH ₂ O-, -CH ₂ CH ₂ CH ₂ S-, -OCH ₂ CH ₂ S- or -CH = CH-CH = CH- may form a 5- or 6-membered ring together with the carbon atom, this time, the hydrogen atoms bonded to each carbon atom forming the ring is a halogen atom, a cyano group, a nitro group, C ₁ -C ₄ alkyl group may be optionally substituted by C ₁ -C ₄ haloalkyl groups, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio group,
E-1 to E-50 each represent a saturated heterocyclic ring represented by the following structural formula,

R ⁵ is a halogen atom, cyano, C _{3 to} C ₈ cycloalkyl, C _{3 to} C ₈ halocycloalkyl, E-1 to E-50, —OH, —OR ⁶ , —SH, —S (O) _r R ⁶ , -N (R ⁸ ) R ⁷ , -N (R ⁸ ) C (O) R ^9a , -C (O) OR ¹⁰ , -C (O) N (R ¹² ) R ¹¹ , -Si (R ^13a ) (R ^13b ) R ¹³ , phenyl, (Z) phenyl substituted by _p1 or D-1 to D-65,
R ⁶ is optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ²² (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ²² (C ₃ ~C ₈ ) Cycloalkyl, E-3 to E-6, E-8, E-10, E-24 to E-26, E-28, E-29, E-31, E-32, E-35, E- 46, C ₂ -C ₆ alkenyl, optionally substituted by R ²² (C ₂ ~C ₆₎ alkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl, optionally substituted by R ²² (C ₃ ~C ₆₎ alkynyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, phenyl, phenyl substituted by (Z) _p1, D-1~D -4, D-6 to D-13, D-15 to D-23, D-25 to D-37, D-39, D-40, D-42, D-43, D-45, D-47 Or D-50 to D-65,
R ⁷ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ ^{haloalkynyl, -C (O) R 9,} -C (O) OR 10, -C (O) SR ^{10, -C (O) N (} R 12) R 11, -C (S) OR 10, -C (S) SR 10, -C (S) N (R 12) R 11, -C (O) C (O) R ¹⁰ , -C (O) C (O) OR ¹⁰ , -OH, -S (O) ₂ R ¹⁰ , -S (O) ₂ N (R ¹² ) R ¹¹ , -P (O) ( OR ¹⁹ ) ₂ or -P (S) (OR ¹⁹ ) ₂
R ⁸ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, -CHO, C ₁ -C ₆ alkylcarbonyl, or represents C ₁ -C ₆ haloalkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl, or , R ⁸ together with R ⁷ represents a C _{2 to} C ₆ alkylene chain, thereby forming a 3- to 7-membered ring with the nitrogen atom to which R ⁷ and R ⁸ are bonded; in this case the alkylene chain is an oxygen atom, may contain one sulfur atom or a nitrogen atom, and optionally substituted halogen atom, C ₁ -C ₄ alkyl group, C ₁ -C ₄ haloalkyl group, the oxo group or thioxo group May have been
R ^7a represents C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₃ -C ₆ alkenyloxy, phenoxy or phenoxy substituted by (Z) _p1 ;
R ^8a represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ alkenyl, phenyl or phenyl substituted by (Z) _{p 1} , or R ^8a is R ^7a Together with C ₄ -C ₆ alkylene chain to form a 5- to 7-membered ring together with the carbon atoms to which R ^7a and R ^8a are attached, wherein the alkylene chain is May contain one oxygen or sulfur atom,
R ⁹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E- 5~E-10, E-24~E- 32, C 2 ~C 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₂ -C ₆ alkynyl or C ₂ -C ₆ haloalkynyl,
R ^9a represents phenyl, phenyl substituted by (Z) _p1 , naphthyl or D-1 to D-65;
R ¹⁰ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E-3 -E -6, E-8, E-10, E-24 to E-26, E-28, E-29, E-31, E-32, E-35, E-38, E-42, E-46 _{, E-49, C 2 ~C} 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ halo Alkynyl, phenyl, phenyl substituted by (Z) _p1 , D-1 to D-4, D-6 to D-13, D-15 to D-23, D-25 to D-37, D-39, D-40, D-42, D-43, D-45, D-47 or D-50 to D-65,
R ¹¹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E- 3 to E-6, E-8, E-10, E-24 to E-26, E-28, E-29, E-31, E-32, E-35, E-38, E-42, E-46, E-49, C 2 ~C 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, phenyl, phenyl substituted by (Z) _p1, D-1 to D-45 or D-47 to D-65
R ¹² is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₄₎ alkyl, or represents C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl, or, R ¹² is R ^{11 represents} a C _{2 to} C ₆ alkylene chain to form a 3- to 7-membered ring together with the nitrogen atom to which R ¹¹ and R ¹² are bonded. oxygen atom may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₄ alkyl group, C ₁ -C ₄ alkoxy group, -CHO group, C ₁ -C ₄ alkylcarbonyl group or a C It may be optionally substituted by ₁ -C ₄ alkoxycarbonyl group,
R ¹³ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, phenyl or phenyl substituted by (Z) _p1 ;
R ^13a and R ^13b each independently represent C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₆ alkoxy;
R ¹⁴ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ haloalkoxycarbonyl (C ₁ -C ₄₎ alkyl, phenyl (C ₁ -C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ -C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ ~ C ₆ represents alkynyl, C ₃ -C ₆ haloalkynyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, phenyl substituted by phenyl or (Z) _p1,
Further, when Z is present at the adjacent position to R ¹⁴ is, -CH ₂ and adjacent R ¹⁴ and _{Z CH 2 CH 2 CH 2 -} , -CH = CH-CH = CH-, -N = CH- An atom to which each of R ¹⁴ and Z is bonded by forming CH = CH-, -CH = N-CH = CH-, -CH = CH-N = CH- or -CH = CH-CH = N- may form a 6-membered ring with a substituted this time, a hydrogen atom is a halogen atom attached to each carbon atom forming the ring, optionally by C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl group May have been
R ¹⁵ is a halogen atom, cyano, nitro, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, hydroxy (C ₃ -C ₈ ) cycloalkyl, C ₁ -C ₄ alkoxy (C ₃ -C ₈₎ cycloalkyl, E-1~E-50, C 5 ~C 10 cycloalkyl, C ₅ -C ₁₀ halo ^{cycloalkenyl, -OR 23, -N (R 24} ) R 23, -C (O) R 26 , -C (R ²⁶ ) = NOH, -C (R ²⁶ ) = NOR ²⁷ , -C (O) OH, -C (O) OR ²⁷ , -C (O) SR ²⁷ , -C (O) N ( R ²⁹ ) R ²⁸ , -C (O) N (R ²⁹ ) OR ²⁷ , -C (O) N (R ²⁹ ) N (R ^28a ) R ²⁸ , -C (O) C (O) OR ²⁷ ,- C (S) OR ²⁷ , -C (S) SR ²⁷ , -C (S) N (R ²⁹ ) R ²⁸ , -C (= NR ²⁸ ) OR ²⁷ , -C (= NR ²⁸ ) SR ²⁷ , -C (= NR ²⁹ ) N (R ^28a ) R ²⁸ , -C (= NOR ²⁷ ) N (R ²⁹ ) R ²⁸ , -S (O) ₂ OH, -S (O) ₂ OR ²⁷ , -S (O) ₂ N (R ²⁹ ) R ²⁸ , -Si (R ^13a ) (R ^13b ) R ¹³ , -P (O) (OR ¹⁹ ) ₂ , -P (S) (OR ¹⁹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , M-1 to M-48, phenyl, phenyl substituted by (Z) _p1 , naphthyl or D-1 to D-65,
R ^15a is a halogen atom, cyano, nitro, C _{3 to} C ₈ cycloalkyl, E- _{5 to} E-8, E-24 to E-29, C _{5 to} C ₁₀ cycloalkenyl, —OR ²³ , —N ( R ²⁴ ) R ²³ , -S (O) _r R ²⁵ , -C (O) R ²⁶ , -C (R ²⁶ ) = NOH, -C (R ²⁶ ) = NOR ²⁷ , M-5, -C (O ) OR ²⁷ , -C (O) SR ²⁷ , -C (O) N (R ²⁹ ) R ²⁸ , M-11, M-28, -C (S) OR ²⁷ , -C (S) SR ²⁷ ,- C (S) N (R ²⁹ ) R ²⁸ , M-14, M-32, -C (O) C (O) OR ²⁷ , -S (O) ₂ N (R ²⁹ ) R ²⁸ , -Si (R ^13a ) (R ^13b ) R ¹³ , -P (O) (OR ¹⁹ ) ₂ , -P (S) (OR ¹⁹ ) ₂ , phenyl, phenyl substituted by (Z) _p1 , D-1 to D-5 , D-14, D-24, D-41, D-21 to D-23 or D-52 to D-59,
M-1 to M-48 each represents a partially saturated heterocyclic ring represented by the following structural formula,

R ¹⁶ represents -SH, -S (O) _r R ²⁵ or -S (O) _t (R ²⁵ ) = NR ^25a ,
R ^16a and R ^16b are each independently a hydrogen atom, a halogen atom, cyano, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ represents alkylthio, C ₁ -C ₄ alkylsulfinyl, C ₁ -C ₄ alkylsulfonyl, C ₁ -C ₄ alkyl Job aryloxycarbonyl, to -C (O) NH ₂ or -C (S) NH _2, respectively R ^16a and each R ^16b may be the same as or different from each other,
R ¹⁷ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³⁰ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E- 3 to E-6, E-8, E-10, E-24 to E-26, E-28, E-29, E-31, E-32, E-35, E-38, E-42, E-46, E-49, C 2 ~C 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl, C ₃ ~ C ₆ haloalkynyl, -C (O) R ²⁶ , -C (O) OR ²⁷ , -C (O) SR ²⁷ , -C (O) N (R ²⁹ ) R ²⁸ , -C (S) R ²⁶ , -C (S) OR ²⁷ , -C (S) SR ²⁷ , -C (S) N (R ²⁹ ) R ²⁸ , -S (O) ₂ R ²⁷ , -S (O) ₂ N (R ²⁹ ) R ²⁸ , -P (O) (OR ¹⁹ ) ₂ , -P (S) (OR ¹⁹ ) ₂ , phenyl, phenyl substituted by (Z) _p1 , D-1 to D-45 or D-47 to D- 65 represents
R ¹⁸ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfonyl (C ₁ -C ₄₎ alkyl, cyano (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ -C ₄₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, or represents C ₃ -C ₆ alkynyl or C ₃ -C ₆ haloalkynyl, Alternatively, R ¹⁸ represents that by together with R ¹⁷ forms a C ₂ -C ₆ alkylene chain, may form a 3- to 7-membered ring together with the nitrogen atom to which R ¹⁷ and R ¹⁸ are bonded In this case the alkylene chain is an oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₄ alkyl groups, C ₁ -C ₂ alkoxy (C ₁ -C ₂₎ alkyl groups, C ₁ -C ₄ alkoxy group, -CHO group may be optionally substituted by C ₁ -C ₄ alkylcarbonyl group or C ₁ -C ₄ alkoxycarbonyl group,
R ^17a is C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₁ -C ₁₂ alkoxy (C ₁ -C ₁₂ ) alkyl, cyano (C ₁ -C ₁₂ ) alkyl, C ₁ -C ₁₂ alkoxycarbonyl (C ₁ ~C ₁₂₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ halo alkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, C ₁ -C ₁₂ alkylcarbonyl, C ₁ -C ₁₂ alkoxycarbonyl, -C (O) ON = C (CH 3) SCH 3, -C (O) ON = C (SCH ₃ ) C (O) N (CH ₃ ) ₂ represents phenyl or phenyl substituted by (Z) _p1 ,
R ^18a is C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₁ -C ₁₂ alkoxy (C ₁ -C ₁₂ ) alkyl, cyano (C ₁ -C ₁₂ ) alkyl, C ₁ -C ₁₂ alkoxycarbonyl (C ₁ ~C ₁₂₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ halo alkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, phenyl or (Z) or represents phenyl which is substituted by _p1, or, R ^18a together with R ^17a C ₄ ~C ₇ alkylene By forming a chain, it represents that a 5- to 8-membered ring may be formed together with the nitrogen atom to which R ^17a and R ^18a are bonded. At this time, the alkylene chain may contain one oxygen atom or sulfur atom. may be optionally substituted and the C ₁ -C ₄ alkyl or C ₁ -C ₄ alkoxy group,
R ¹⁹ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ²⁰ is a halogen atom, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ -C ₄₎ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylamino, di (C ₁ -C ₆ alkyl) amino, C ₁ ~ C ₆ alkoxycarbonyl, phenyl or phenyl substituted by (Z) _{p 1} , and when q 1 to q 8 represent an integer of 2 or more, each R ²⁰ may be the same as or different from each other Well, furthermore, when two R ²⁰ are substituted on the same carbon atom, the two R ²⁰ together are oxo, thioxo, imino, C ₁ -C ₄ alkylimino, C ₁ -C ₄ alkoxy It indicates that may form an imino or C ₁ -C ₄ alkylidene,
R ²¹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³⁰ , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, -OH, ^{benzyloxy, -C (O) R 31,} -C (O) OR 32, -C (O) SR 32, -C (O) N (R 34 ) R ³³ , -C (S) N (R ³⁴ ) R ³³ , -S (O) ₂ R ³² , -P (O) (OR ¹⁹ ) ₂ , -P (S) (OR ¹⁹ ) ₂ , phenyl, (Z) represents phenyl or D-5 substituted by _p1 ,
R ²² is a halogen atom, cyano, C _{3 to} C ₈ cycloalkyl, C _{3 to} C ₈ halocycloalkyl, E-1 to E-50, C _{1 to} C ₆ alkoxy, C _{1 to} C ₆ haloalkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, C ₁ -C ₆ alkylamino, di (C ₁ -C ₆ alkyl) amino, - CHO, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, C ₁ -C ₆ alkylaminocarbonyl, di (C ₁ -C ₆ alkyl) aminocarbonyl, phenyl, (Z) phenyl substituted by _p1 or D-1 to D-65,
R ²³ is a hydrogen atom, C ₁ -C ₈ alkyl, optionally substituted by R ³⁰ (C ₁ ~C ₈₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally substituted by R ³⁰ (C ₃ -C ₈₎ cycloalkyl, E-3~E-6, E -8, E-10, E-24~E-26, E-28, E-29, E-31, E-32, E-35 , E-38, E-42 , E-46, E-49, C 3 ~C 8 alkenyl, optionally substituted by R ³⁰ (C ₃ ~C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, R ³⁰ optionally substituted by (C ₃ ~C ₈₎ ^{alkynyl, -C (O) R 31,} -C (O) OR 32, -C (O) SR 32, -C (O) N (R 34) R ³³ , -C (O) C (O) R ³² , -C (O) C (O) OR ³² , -C (S) R ³¹ , -C (S) OR ³² , -C (S) SR ³² , -C (S) N (R ³⁴ ) R ³³ , -S (O) ₂ R ³² , -S (O) ₂ N (R ³⁴ ) R ³³ , -Si (R ^13a ) (R ^13b ) R ¹³ ,- P (O) (OR ¹⁹ ) ₂ , -P (S) (OR ¹⁹ ) ₂ , phenyl, phenyl substituted by (Z) _p1 , D-1 to D-4, D-6 to D-13, D -15 to D-23, D-25 to D-37, D-39, D-40, D-42, D-43, D-45, D-47 or D-50 to D-65,
R ²⁴ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₄ cycloalkyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, C _{1 to} C ₆ alkoxy, phenyl or phenyl substituted by (Z) _{p 1} , or R ²⁴ together with R ²³ forms a C _{2 to} C ₅ alkylene chain, thereby allowing R ²³ and R ²⁴ represents that a 3- to 6-membered ring may be formed together with the nitrogen atom to which ²⁴ is bonded, in which case the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and a halogen atom, C _1- C ₄ alkyl group, C ₁ -C ₄ haloalkyl groups, C ₁ -C ₄ alkoxy group, -CHO group, C ₁ -C ₄ alkylcarbonyl group, C ₁ -C ₄ alkoxy May be substituted by a xycarbonyl group, a phenyl group, a phenyl group substituted by (Z) _p1 , an oxo group or a thioxo group,
R ²⁵ is, C ₁ -C ₈ alkyl, optionally substituted by R ³⁰ (C ₁ ~C ₈₎ alkyl, optionally substituted by C ₃ -C ₈ cycloalkyl, R ³⁰ (C ₃ ~C ₈ ) Cycloalkyl, E-3, E-4, E-6, E-8, E-10, E-25, E-26, E-28, E-29, E-31, E-32, E- 35, E-38, E- 42, E-46, E-49, C 3 ~C 8 alkenyl, optionally substituted by R ³⁰ (C ₃ ~C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, R optionally substituted by ³⁰ (C ₃ ^~C ₈₎ ^{alkynyl, -C (O) R 31,} -C (O) OR 32, -C (O) SR 32, -C (O) N (R 34) R ³³ , -C (O) C (O) R ³² , -C (O) C (O) OR ³² , -C (S) R ³¹ , -C (S) OR ³² , -C (S) SR ³² , -C (S) N (R 34) R 33, -SH, C 1 ~C 6 alkylthio, C ₁ -C ₆ haloalkylthio, phenylthio, phenylthio substituted by _{(Z) p1, -P (O} ) ( _{^{OR 19) 2, -P (S}} ) (OR 19) 2, phenyl, (Z) phenyl substituted by _{p1, D-18, D-} 21, D-25, D-30~D-35, D- 50, D-52, D-55, D-56, D-58 It represents the D-59,
R ^25a is a hydrogen atom, cyano, nitro, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, represents C ₁ -C ₆ alkylsulfonyl or C ₁ -C ₆ haloalkylsulfonyl,
R ²⁶ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ haloalkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylsulfonyl (C _{1 ~C 4)} alkyl, C ₁ -C ₆ haloalkylsulfonyl (C _{1 ~C 4)} alkyl, phenyl (C _{1 ~C 4)} alkyl, phenyl substituted by (Z) _p1 (C ₁ ~C ₄₎ represents alkyl, C ₃ -C ₆ cycloalkyl, phenyl substituted by phenyl or (Z) _p1,
R ²⁷ is optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ³⁰ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ³⁰ (C ₃ ~C ₈ ) Cycloalkyl, E-3 to E-6, E-8, E-10, E-24 to E-26, E-28, E-29, E-31, E-32, E-35, E- 38, E-42, E- 46, E-49, C 2 ~C 6 alkenyl, optionally substituted by R ³⁰ (C ₂ ~C ₆₎ alkenyl, C ₃ -C ₆ alkynyl, optionally by R ³⁰ substituted (C ₃ ~C ₆₎ alkynyl, phenyl, (Z) phenyl substituted by _{p1, D-1~D-4,} D-6~D-13, D-15~D-23, D- 25-D-37, D-39, D-40, D-42, D-43, D-45, D-47 or D-50-D-65,
R ²⁸ is a hydrogen atom, C ₁ -C ₆ alkyl, optionally substituted by R ³⁰ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally substituted by R ³⁰ (C ₃ -C ₈₎ cycloalkyl, E-3~E-6, E -8, E-10, E-24~E-26, E-28, E-29, E-31, E-32, E-35 , E-38, E-42 , E-46, E-49, C 2 ~C 6 alkenyl, optionally substituted by R ³⁰ (C ₂ ~C ₆₎ alkenyl, C ₃ -C ₈ alkynyl, R ³⁰ optionally substituted by (C ₃ ~C ₆₎ alkynyl, phenyl, represents phenyl, D-1 to D-45 or D-47~D-65 substituted by (Z) _p1,
R ^28a represents a hydrogen atom or a C ₁ -C ₄ alkyl,
R ²⁹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted with R ³⁰ , C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C Represents ₆ alkynyl, C ₃ -C ₆ haloalkynyl, phenyl or phenyl substituted by (Z) _{p 1} , or R ²⁹ together with R ²⁸ forms a C ₂ -C ₅ alkylene chain , R ²⁸ and R ²⁹ may form a 3- to 6-membered ring together with the nitrogen atom to which R ²⁸ and R ²⁹ are bonded, wherein the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and halogen atom, C ₁ -C ₄ alkyl group, C ₁ -C ₄ alkoxy group, -CHO group, C ₁ -C ₄ alkylcarbonyl group, C ₁ -C ₄ alkoxycarbonyl group, a phenyl group, substituted by (Z) _p1 Optionally substituted by a phenyl group or an oxo group,
R ³⁰ is a halogen atom, cyano, nitro, C _{3 to} C ₈ cycloalkyl, C _{3 to} C ₈ halocycloalkyl, E-5 to E-8, E-11 to E-13, E-19, E- 20, E-24~E-29, E-33~E-36, E-44~E-46, C 2 ~C 6 alkenyl, C ₂ -C ₆ haloalkenyl, -OH, -OR ^32, -OC (O) R ³¹ , -OC (O) OR ³² , -OC (O) N (R ³⁴ ) R ³³ , -OC (S) N (R ³⁴ ) R ³³ , -SH, -S (O) _r R ³² , -SC (O) R ³¹ , -SC (O) OR ³² , -SC (O) N (R ³⁴ ) R ³³ , -SC (S) N (R ³⁴ ) R ³³ , -N (R ³⁴ ) R ³³ , -N (R ³⁴ ) CHO, -N (R ³⁴ ) C (O) R ³¹ , -N (R ³⁴ ) C (O) OR ³² , -N (R ³⁴ ) C (O) N (R ³⁴ ) R ³³ , -N (R ³⁴ ) C (S) N (R ³⁴ ) R ³³ , -N (R ³⁴ ) S (O) ₂ R ³² , -C (O) R ³¹ , -C (O) OH, -C (O) OR ³² , -C (O) SR ³² , -C (O) N (R ³⁴ ) R ³³ , -C (O) C (O) OR ³² , -Si (R ^13a ) ( R ^13b ) R ¹³ , -P (O) (OR ¹⁹ ) ₂ , -P (S) (OR ¹⁹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , phenyl, (Z) represents phenyl substituted by _p1 or D-1 to D-65;
R ³¹ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³⁵ , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, E-5~E-8, E -24~E-29, C 2 ~C 8 alkenyl, C ₂ -C ₈ haloalkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo represents cycloalkenyl, C ₂ -C ₈ alkynyl, C ₂ -C ₈ haloalkynyl, phenyl, phenyl or D-1 to D-65 substituted by (Z) _p1,
R ³² is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³⁵ , C ₃ -C ₆ cycloalkyl, E-6, E-8 , C ₂ -C ₈ represents alkenyl, C ₂ -C ₈ haloalkenyl, a C ₃ -C ₈ alkynyl or phenyl,
R ³³ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³⁵ , C ₃ -C ₆ cycloalkyl, E-5, E-6 , E-8, E-24 , C 2 ~C 8 alkenyl, C ₂ -C ₈ haloalkenyl, C ₃ -C ₈ alkynyl, phenyl, phenyl substituted by _{(Z) p1, D-1~D} -45 Or D-47 to D-65,
R ³⁴ represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₈ cycloalkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl, or R ³⁴ Represents that, together with R ³³ , a C ₂ -C ₅ alkylene chain may be formed to form a 3- to 6-membered ring with the nitrogen atom to which R ³³ and R ³⁴ are bonded. alkylene chain oxygen atom may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₄ alkyl group, C ₁ -C ₄ alkoxy group, -CHO group, C ₁ -C ₄ alkylcarbonyl group , C ₁ -C ₄ alkoxycarbonyl group, may be optionally substituted by a phenyl group substituted by a phenyl group or (Z) _p1,
R ³⁵ is cyano, C _{3 to} C ₆ cycloalkyl, C _{3 to} C ₆ halocycloalkyl, E-5 to E-8, E-24 to E-29, C _{1 to} C ₄ alkoxy, C _{1 to} C ₄ haloalkoxy, phenoxy, (Z) _p1 phenoxy substituted by, C ₁ -C ₄ alkylthio, C ₁ -C ₄ haloalkylthio, phenylthio, (Z) phenylthio substituted by _p1, C ₁ -C ₄ alkylsulfonyl , C ₁ -C ₄ haloalkylsulfonyl, phenylsulfonyl, (Z) phenylsulfonyl substituted by ^{_{p1, -N (R 37) R}} 36, C 1 ~C 6 alkyl carbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, di (C ₁ -C ₆ alkyl) aminocarbonyl, tri (C ₁ -C ₄ alkyl) silyl, phenyl, (Z) phenyl substituted by _p1, naphthyl or D-1 to D-65 Represents
R ³⁶ is phenyl substituted by a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, phenylcarbonyl or (Z) _p1 Represents carbonyl,
R ³⁷ represents a hydrogen atom or C ₁ -C ₆ alkyl,
m represents an integer of 0 to 5;
n represents an integer of 2 to 4,
p1 represents an integer of 1 to 5,
p2 represents an integer of 0 to 4,
p3 represents an integer of 0 to 3,
p4 represents an integer of 0 to 2,
p5 represents an integer of 0 or 1,
q1 represents an integer of 0 to 2,
q2 represents an integer of 0 to 3,
q3 represents an integer of 0 to 4,
q4 represents an integer of 0 to 5,
q5 represents an integer of 0 to 6,
q6 represents an integer of 0 to 7,
q7 represents an integer of 0 to 8,
q8 represents an integer of 0 to 9,
r represents an integer of 0 to 2;
t represents an integer of 0 or 1. ]
Or a salt thereof.

[2] A ¹ , A ² and A ⁴ each independently represent CY or N;
A ³ represents CH or N,
G represents a benzene ring,
L is -C (R ⁴ ) (R ^4a )-, -C (R ⁴ ) (R ^4a ) CH _2- , -N (R ^4b )-or -C (R ⁴ ) (R ^4a ) N (R ^4b )-
X is a halogen atom, cyano, nitro, -SF _5, C ₁ ~C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ ~C ₄₎ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) Represents haloalkyl, —OR ⁶ , —S (O) _r R ⁶ or —NH _2, and when m represents an integer of 2 or more, each X may be the same as or different from each other. ,
Further, when two X are adjacent, the two X adjacent the _{-CF 2 OCF 2 -, - OCF} 2 O -, - CF 2 OCF 2 O- or -OCF ₂ CF ₂ O-to form a May form a 5- or 6-membered ring with the carbon atom to which each is attached,
Y is a hydrogen atom, a halogen atom, cyano, nitro, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, substituted by R ⁵ (C ₁ ~C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C _{2 to} C ₆ alkynyl, -OR ⁶ , -S (O) _r R ⁶ , -N (R ⁸ ) R ⁷ , -C (S) NH ₂ , D-1 to D-5, D-14, D- 24 or D-41, when two or more Y are present, each Y may be the same as or different from each other;
Further, when two Ys are adjacent to each other, the two adjacent Ys may form a 6-membered ring with the carbon atom to which each of the two Ys is bonded by forming -CH = CHCH = CH-. Often,
R ¹ is a hydrogen atom, -C (O) R ^1a , -C (O) OR ^1b , -C (O) SR ^1b , -C (O) N (R ^1d ) R ^1c , -C (S) R ^1a , -C (S) OR ^1b , -C (S) SR ^1b , -C (S) N (R ^1d ) R ^1c or -S (O) ₂ R ^1b
R ^1a is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ ,-[C (R ^16a ) (R ^16b )] _n − R ¹⁶ , C ₃ -C ₇ cycloalkyl, C ₃ -C ₆ halocycloalkyl, cyano (C ₃ -C ₆ ) cycloalkyl, phenyl (C ₃ -C ₆ ) cycloalkyl, E-5, E-6, E-21, E-22, E-24~E-26, C 2 ~C 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ alkynyl, C ₂ -C ₆ haloalkynyl, -C (O ) R ⁹ , -C (R ⁹ ) = NOR ¹⁰ , M-7, -C (O) OR ¹⁰ , -C (O) N (R ¹² ) R ¹¹ , phenyl, phenyl substituted by (Z) _p1 , D-1 to D-4, D-15 to D-17, D-21 to D-24 or D-52 to D-59,
R ^1b represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl or phenyl,
R ^1c is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , -CH ₂ CH ₂ -R ¹⁶ , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ ^{alkynyl, -C (R 9) = NOR} 10, C 1 ~C 6 alkoxycarbonyl, M-14, M-32 , C 1 ~C 6 alkoxy, C ₁ -C ₆ ^{alkylsulfonyl, -N (R 18) R 17} , represents phenyl, phenyl or D-52~D-54 substituted by (Z) _p1,
R ^1d represents a hydrogen atom, C ₁ -C ₆ alkyl or benzyl, or R ^1d together with R ^1c forms a C ₄ -C ₅ alkylene chain, whereby R ^1c and R ^1d are with bound nitrogen atom indicates that may form a 5- or 6-membered ring, this time the alkylene chain an oxygen atom, may contain one sulfur atom or a nitrogen atom, and C ₁ -C ₄ alkyl group, -CHO group, C ₁ -C ₄ alkylcarbonyl group, C ₁ -C ₄ alkoxycarbonyl group, C ₁ -C ₄ alkylaminocarbonyl group, C ₁ -C ₄ halo alkylaminocarbonyl group, di (C ₁ -C ₄ alkyl Optionally substituted by an aminocarbonyl group or an oxo group,
R ² is a hydrogen atom, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ^15a , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkylthio or -SN (R ^18a) R ^17a or it represents, or, R ² is by together with R ¹ to form a C ₄ -C ₆ alkylene chain, may form a 5- to 7 membered ring together with the nitrogen atom R ¹ and R ² are bonded indicates that, this time the alkylene chain an oxygen atom, may contain one sulfur atom or a nitrogen atom, and C ₁ -C ₄ alkyl group, C ₁ -C ₄ alkylidene group, optionally by an oxo group or thioxo group May be replaced,
R ³ represents C ₁ -C ₆ haloalkyl or C ₃ -C ₈ halocycloalkyl,
R ⁴ is a hydrogen atom, cyano, C ₁ -C ₃ alkyl, C ₁ -C ₃ haloalkyl, C ₃ -C ₄ cycloalkyl, C ₂ -C ₃ alkynyl, -C (O) NH ₂ , -C (S ) Represents NH ₂ , phenyl, D-18 or D-21,
R ^4a represents a hydrogen atom or C ₁ -C ₃ alkyl, or R ^4a together with R ⁴ forms an ethylene chain to form cyclopropyl together with the carbon atom to which R ⁴ and R ^4a are attached. Represents that a ring may be formed,
R ^4b represents a hydrogen atom, C ₁ -C ₃ alkyl, C ₁ -C ₃ alkylcarbonyl, a C ₃ -C ₄ cycloalkyl carbonyl or C ₁ -C ₃ alkoxycarbonyl,
Z is a halogen atom, cyano, nitro, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ alkylthio or C ₁ -C ₄ represents haloalkylthio, and when p1 to p4 represent an integer of 2 or more, each Z may be the same as or different from each other;
R ⁵ represents -OH, C ₁ -C ₄ alkoxy, C ₁ -C ₄ alkylthio, C ₁ -C ₄ alkylsulfinyl or C ₁ -C ₄ alkylsulfonyl,
R ⁶ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₄ haloalkoxy (C ₁ -C ₄ ) haloalkyl,
R ⁷ represents a hydrogen atom, C ₁ -C ₆ alkyl, —CHO, C ₁ -C ₆ alkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl,
R ⁸ represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ⁹ represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ¹⁰ represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ¹¹ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or C ₃ -C ₆ cycloalkyl,
R ¹² represents a hydrogen atom,
R ¹⁴ represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ¹⁵ is cyano, C _{3 to} C ₆ cycloalkyl, E-5 to E-8, E-24, E-25, E-27, E-28, C _{5 to} C ₆ cycloalkenyl, —OR ²³ , -N (R ²⁴ ) R ²³ , -C (O) OR ²⁷ , -C (O) N (R ²⁹ ) R ²⁸ , -C (S) N (R ²⁹ ) R ²⁸ , -C (= NOH) N ^{(R 29) R 28, -C} (= NOR 27) N (R 29) R 28, tri (C ₁ ~C ₄₎ alkylsilyl, phenyl, phenyl substituted by _{(Z) p1, D-1} , D -3, D-21, D-22 or D-52 to D-54,
R ^15a is cyano, C ₃ -C ₆ cycloalkyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ alkylthio, C ₁ -C ₄ alkylsulfinyl, C ₁ -C ₄ alkyl Represents sulfonyl, -N (R ²⁴ ) R ²³ , -C (O) OR ²⁷ , -C (O) N (R ²⁹ ) R ²⁸ , -C (S) NH ₂ or phenyl;
R ¹⁶ represents -S (O) _r R ²⁵ or -S (O) _t (R ²⁵ ) = NR ^25a ,
R ^16a and R ^16b each independently represent a hydrogen atom or C ₁ -C ₂ alkyl, each R ^16a and each R ^16b may be the same or different from each other,
R ¹⁷ is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, -C (O) R ²⁶ , -C (O) OR ²⁷ , -C (O) N (R ²⁹ ) R ²⁸ , -C (S) N (R ²⁹ ) R ²⁸ , phenyl or phenyl substituted by (Z) _p1 ,
R ¹⁸ represents a hydrogen atom or C ₁ -C ₄ alkyl, or R ¹⁸ together with R ¹⁷ forms a C ₄ -C ₅ alkylene chain, thereby binding R ¹⁷ and R ¹⁸ Represents that a 5- to 6-membered ring may be formed together with the nitrogen atom, and this alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and a C ₁ -C ₄ alkyl group, —CHO group may be optionally substituted by C ₁ -C ₄ alkylcarbonyl group or C ₁ -C ₄ alkoxycarbonyl group,
R ^17a represents C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxycarbonyl (C ₁ -C ₄ ) alkyl or C ₁ -C ₆ alkoxycarbonyl,
R ^18a represents C ₁ -C ₆ alkyl or benzyl,
R ²⁰ represents C ₁ -C ₂ alkyl, and when q 3, q 4 and q 5 represent 2, each R ²⁰ may be the same as or different from each other,
R ²¹ represents a hydrogen atom, C ₁ -C ₄ alkylcarbonyl or C ₁ -C ₄ alkoxycarbonyl,
R ²³ is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ cycloalkyl (C ₁ ~C ₂₎ alkyl, cyano (C ₁ ~C ₂₎ alkyl, C ₃ ~ C ₄ cycloalkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ ^{alkynyl, -C (O) R 31,} -C (O) OR 32, -C (O) SR 32, -C (O) N ( R ³⁴ ) R ^{33 represents} C ₁ -C ₄ alkylsulfonyl, C ₁ -C ₄ haloalkylsulfonyl, phenyl or phenyl substituted by (Z) _p1 ;
R ²⁴ is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ alkylcarbonyl, C ₁ -C ₄ haloalkylcarbonyl, C ₁ -C ₄ alkoxy or a carbonyl or C ₁ -C ₄ alkylsulfonyl, or , R ²⁴ together with R ²³ represents a C _{4 to} C ₅ alkylene chain, thereby forming a 5- to 6-membered ring together with the nitrogen atom to which R ²³ and R ²⁴ are bonded; At this time, the alkylene chain may contain one oxygen atom or sulfur atom, and may be optionally substituted with an oxo group,
R ²⁵ is C ₁ -C ₄ alkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³⁰ , C ₃ -C ₄ alkenyl, C ₃ -C ₄ alkynyl, -C (O) R ³¹ , Represents -C (O) OR ³² or -C (O) N (R ³⁴ ) R ³³ ,
R ^25a represents a hydrogen atom, cyano or C ₁ -C ₂ haloalkylcarbonyl,
R ²⁶ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₆ cycloalkyl or phenyl;
R ²⁷ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or C ₃ -C ₆ cycloalkyl,
R ²⁸ is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ cycloalkyl (C ₁ -C ₂ ) alkyl, C ₃ -C ₆ cycloalkyl or C ₁ -C ₄ Represents haloalkylcarbonyl,
R ²⁹ represents a hydrogen atom or C ₁ -C ₄ alkyl, or R ²⁹ together with R ²⁸ forms a C ₄ -C ₅ alkylene chain, thereby bonding R ²⁸ and R ²⁹ . Represents that a 5- to 6-membered ring may be formed together with the nitrogen atom, in which case the alkylene chain may contain one oxygen atom or sulfur atom, and may be optionally substituted with an oxo group,
R ³⁰ represents a halogen atom, cyano or -C (O) N (R ³⁴ ) R ³³ ,
R ³¹ is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₂ alkoxy (C ₁ -C ₂ ) alkyl, C ₃ -C ₆ cycloalkyl, phenyl, D-24 or D-52 ~ Represents D-54,
R ³² represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ³³ represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ³⁴ represents a hydrogen atom or C ₁ -C ₄ alkyl,
m represents an integer of 1 to 3,
n represents 2,
p2 represents an integer of 0 to 3,
p3 represents an integer of 0 to 2,
p5 represents 1,
q2 represents 0,
q3 and q5 represent an integer of 0 to 2,
q4 represents an integer of 0 to 2,
q6 and q8 are the substituted isoxazoline compounds or salts thereof according to the above [1], wherein 0 is 0

[3] A ¹ represents CY or N;
A ² and A ³ represent CH,
A ⁴ represents CH or N;
L represents -C (R ⁴ ) (R ^4a )-
X is a halogen atom, cyano, nitro, -SF _5, C ₁ ~C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ alkylthio or When C represents C ₁ -C ₄ haloalkylthio and m represents 2 or 3, each X may be the same as or different from each other;
Y is a hydrogen atom, a halogen atom, cyano, nitro, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₂ -C ₄ alkynyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ represents alkylthio, a C ₁ -C ₄ haloalkylthio or -C (S) NH _2,
R ¹ is -C (O) R ^1a , -C (O) OR ^1b , -C (O) SR ^1b , -C (O) N (R ^1d ) R ^1c , -C (S) R ^{1a or-} C (S) N (R ^1d ) R ^1c
R ^1a is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , -CH ₂ CH ₂ -R ¹⁶ , C ₃ -C ₄ cycloalkyl, E-5, E-6 , C 2 ~C 4 alkenyl, C ₂ -C ₄ haloalkenyl, C ₂ -C ₄ ^{alkynyl, -C (R 9) = NOR} 10, is substituted by (Z) _p1 Represents phenyl, D-3, D-17 or D-53,
R ^1b represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ^1c is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , C ₃ -C ₄ cycloalkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ represents an alkynyl, a C ₁ -C ₄ alkoxy, C ₁ -C ₄ alkylsulfonyl or -N (R ¹⁸⁾ R ^17,
R ^1d represents a hydrogen atom or C ₁ -C ₄ alkyl, or R ^1d together with R ^1c forms a C ₄ -C ₅ alkylene chain, thereby binding R ^1c and R ^1d . It represents that a 5- to 6-membered ring may be formed together with a nitrogen atom, and this alkylene chain may contain one oxygen atom or sulfur atom, and may be optionally substituted with a methyl group or an oxo group. Often,
R ² represents a hydrogen atom, C ₁ -C ₄ alkyl, (C ₁ -C ₂ ) alkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ alkynyl or C ₁ -C ₄ alkoxy substituted by R ^15a . Represent,
R ³ represents C ₁ -C ₄ haloalkyl,
R ⁴ represents a hydrogen atom, cyano, methyl, trifluoromethyl, ethynyl or —C (S) NH ₂ ;
R ^4a represents a hydrogen atom, or R ^4a together with R ⁴ may form an ethylene chain to form a cyclopropyl ring together with the carbon atom to which R ⁴ and R ^4a are bonded. Represents
Z is a halogen atom, cyano, nitro, C ₁ -C ₄ alkyl or C ₁ -C ₄ alkylthio, when p1 and p2 represents an integer of 2 or more, each Z may may be the same with each other or one another They may be different,
R ⁹ represents a hydrogen atom,
R ¹⁰ represents C ₁ -C ₂ alkyl,
R ¹⁴ represents C ₁ -C ₂ alkyl,
R ¹⁵ is cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or -C (O) N (R ²⁹ ) R ²⁸ Represents
R ^15a is cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, C ₁ -C ₂ alkylthio, -N (R ²⁴ ) R ²³ , C ₁ -C ₂ alkoxycarbonyl, it represents a ^{-C (O) N (R 29} ) R 28 or -C (S) NH _2,
R ¹⁶ represents -S (O) _r R ²⁵ ,
R ¹⁷ represents a hydrogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₂ alkoxycarbonyl,
R ¹⁸ represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ²³ is C ₁ -C ₂ alkyl, cyano (C ₁ -C ₂ ) alkyl, -C (O) R ³¹ , -C (O) OR ³² , -C (O) SR ³² or C ₁ -C ₂ Represents alkylsulfonyl,
R ²⁴ represents a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkylcarbonyl, C ₁ -C ₂ alkoxycarbonyl or C ₁ -C ₂ alkylsulfonyl,
R ²⁵ represents C ₁ -C ₂ alkyl,
R ²⁸ represents a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyclopropylmethyl,
R ²⁹ represents a hydrogen atom or C ₁ -C ₂ alkyl,
R ³¹ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or C ₃ -C ₄ cycloalkyl,
R ³² represents C ₁ -C ₂ alkyl,
p1 represents an integer of 1 to 3,
p2 represents an integer of 0 to 2,
p3 and p4 represent an integer of 0 or 1,
The substituted isoxazoline compound or a salt thereof according to the above [2], wherein t represents 0.

[4] L represents —CH (R ⁴ ) —,
X represents a halogen atom, cyano, —SF ₅ , C ₁ -C ₂ haloalkyl, C ₁ -C ₂ haloalkoxy or C ₁ -C ₂ haloalkylthio, and when m represents 2 or 3, each X is They may be the same or different from each other,
Y is a hydrogen atom, a halogen atom, cyano, nitro, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl, C ₂ -C ₃ alkynyl, C ₁ -C ₂ haloalkoxy, C ₁ -C ₂ haloalkylthio or represents -C (S) NH _2,
R ¹ represents -C (O) R ^1a , -C (O) SR ^1b , -C (O) N (R ^1d ) R ^1c or -C (S) R ^1a ,
R ^1a is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , C ₃ -C ₄ cycloalkyl, E-6, C ₂ -C ₄ represents alkenyl, C ₂ -C ₄ haloalkenyl, C ₂ -C ₄ alkynyl, phenyl or D-53 substituted by (Z) _p1,
R ^1b represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ^1c represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ cycloalkyl or C ₃ -C ₄ alkynyl,
R ^1d represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ² represents a hydrogen atom, C ₁ -C ₄ alkyl, (C ₁ -C ₂ ) alkyl substituted by R ^15a , C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ³ represents C ₁ -C ₂ haloalkyl,
R ⁴ represents a hydrogen atom, cyano, methyl, ethynyl or —C (S) NH ₂ ;
Z represents a halogen atom, cyano, nitro or C ₁ -C ₄ alkylthio, when p1 and p2 represents an integer of 2 or more, each Z may be the even or different from each other the same as each other,
R ¹⁵ represents C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or -C (O) N (R ²⁹ ) R ²⁸ ,
R ^15a represents cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or C ₁ -C ₂ alkoxycarbonyl,
R ²³ represents cyano (C ₁ -C ₂ ) alkyl, -C (O) R ³¹ or C ₁ -C ₂ alkoxycarbonyl,
R ²⁴ represents a hydrogen atom or C ₁ -C ₂ alkoxycarbonyl,
R ²⁸ represents a hydrogen atom or C ₁ -C ₂ alkyl,
The substituted isoxazoline compound or a salt thereof according to the above [3], wherein R ³¹ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyclopropyl.

[5] A ¹ represents CY,
A ⁴ represents CH,
X represents a halogen atom or trifluoromethyl, and when m represents 2 or 3, each X may be the same as or different from each other;
Y represents a hydrogen atom, a halogen atom, nitro or methyl,
R ¹ represents -C (O) R ^1a or -C (O) NHR ^1c ,
R ^1a represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, cyclopropylmethyl, cyclopropyl or E-6,
R ^1c represents C ₁ -C ₃ alkyl, C ₁ -C ₃ haloalkyl, cyclopropyl or propargyl,
R ² represents a hydrogen atom, C ₁ -C ₂ alkyl, cyclopropylmethyl, C ₁ -C ₂ alkoxymethyl, cyanomethyl, allyl or propargyl,
R ³ represents trifluoromethyl or chlorodifluoromethyl,
R ⁴ represents a substituted isoxazoline compound or a salt thereof according to the above [4], wherein R ⁴ represents a hydrogen atom, cyano or methyl.

  [6] General formula (1a):

[Wherein A ¹ represents CY or N;
A ⁴ represents CH or N;
Y is a hydrogen atom, a halogen atom, cyano, nitro, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl, C ₂ -C ₃ alkynyl, C ₁ -C ₂ haloalkoxy, C ₁ -C ₂ haloalkylthio or represents -C (S) NH _2,
R ¹ represents -C (O) R ^1a or -C (S) R ^1a ,
R ^1a is -C (R ^16a ) (R ^16b ) -S (O) _r R ²⁵ , -C (R ^16a ) (R ^16b ) -S (O) _t (R ²⁵ ) = NR ^25a , E-7 , E-8, E-51 or E-52,
R ² represents a hydrogen atom, C ₁ -C ₂ alkyl, methyl, allyl or propargyl substituted by R ^15a ;
R ³ represents C ₁ -C ₂ haloalkyl,
R ⁴ represents a hydrogen atom, cyano, methyl, ethynyl or —C (S) NH ₂ ;
E-7, E-8, E-51 and E-52 each represent a saturated heterocyclic ring represented by the following structural formula,

R ^15a is cyano, cyclopropyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, C ₁ -C ₂ alkoxycarbonyl, -C (O) N (R ²⁹ ) R ²⁸ or -C (S) NH ₂
R ^16a represents a hydrogen atom, a fluorine atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ alkylthio or C ₁ -C ₂ alkylsulfinyl,
R ^16b represents a hydrogen atom or a fluorine atom,
R ²⁵ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyanomethyl;
R ^25a represents a hydrogen atom or C ₁ -C ₂ haloalkylcarbonyl,
R ²⁸ represents a hydrogen atom or C ₁ -C ₂ alkyl,
R ²⁹ represents a hydrogen atom or methyl,
q6 represents 0,
r represents an integer of 0 to 2;
t represents an integer of 0 or 1. ]
Or a salt thereof.

[7] A ¹ represents CY,
A ⁴ represents CH,
Y represents a hydrogen atom, a halogen atom, nitro or methyl,
R ^1a represents -C (R ^16a ) (R ^16b ) -S (O) _r R ²⁵ or E-7,
R ² represents a hydrogen atom, C ₁ -C ₂ alkyl or propargyl,
R ³ represents trifluoromethyl or chlorodifluoromethyl,
R ⁴ represents a hydrogen atom or methyl,
R ^16a is a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ alkylthio or C ₁ -C ₂ alkylsulfinyl,
R ^16b represents a hydrogen atom,
R ²⁵ represents a substituted isoxazoline compound or a salt thereof according to the above [6], wherein R ²⁵ represents C ₁ -C ₂ alkyl or C ₁ -C ₂ haloalkyl.

  [8] General formula (2):

[Wherein A ¹ represents CY or N;
A ⁴ represents CH or N;
J represents a hydrogen atom or a halogen atom,
L represents -C (R ⁴ ) (R ^4a )-
Y is a hydrogen atom, a halogen atom, cyano, nitro, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₂ -C ₄ alkynyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy or - It represents C (S) NH _2,
R ¹ is -C (O) R ^1a , -C (O) OR ^1b , -C (O) SR ^1b , -C (O) N (R ^1d ) R ^1c , -C (S) R ^{1a or-} C (S) N (R ^1d ) R ^1c
R ^1a is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ ,-[C (R ^16a ) (R ^16b )] _n − R ^16, C ₃ ~C ₄ cycloalkyl, E-5~E-8, E -51, E-52, C 2 ~C 4 alkenyl, C ₂ -C ₄ haloalkenyl, C ₂ -C ₄ alkynyl, ( Z) represents phenyl, D-3, D-17 or D-53 substituted by _p1 ,
R ^1b represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ^1c is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , C ₃ -C ₄ cycloalkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ represents an alkynyl, a C ₁ -C ₄ alkoxy, C ₁ -C ₄ alkylsulfonyl or -N (R ¹⁸⁾ R ^17,
R ^1d represents a hydrogen atom or C ₁ -C ₄ alkyl, or R ^1d together with R ^1c forms a C ₄ -C ₅ alkylene chain, thereby binding R ^1c and R ^1d . It represents that a 5- to 6-membered ring may be formed together with a nitrogen atom, and this alkylene chain may contain one oxygen atom or sulfur atom, and may be optionally substituted with a methyl group or an oxo group. Often,
R ² represents a hydrogen atom, C ₁ -C ₄ alkyl, (C ₁ -C ₂ ) alkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ alkynyl or C ₁ -C ₄ alkoxy substituted by R ^15a . Represent,
R ⁴ represents a hydrogen atom, cyano, methyl, trifluoromethyl, ethynyl or —C (S) NH ₂ ;
R ^4a represents a hydrogen atom, or R ^4a together with R ⁴ may form an ethylene chain to form a cyclopropyl ring together with the carbon atom to which R ⁴ and R ^4a are bonded. Represents
D-3, D-17 and D-53 each represent an aromatic heterocycle represented by the following structural formula,

Z represents a halogen atom, cyano, nitro or C ₁ -C ₄ alkyl, when p1 and p2 represents an integer of 2 or more, each Z may be the even or different from each other the same as each other,
R ¹⁴ represents C ₁ -C ₂ alkyl,
E-5 to E-8, E-51 and E-52 each represent a saturated heterocyclic ring represented by the following structural formula,

R ¹⁵ is cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or -C (O) N (R ²⁹ ) R ²⁸ Represents
R ^15a is cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ , C ₁ -C ₂ alkoxycarbonyl, -C (O ) N (R ²⁹ ) R ²⁸ or -C (S) NH ₂
R ¹⁶ represents -S (O) _r R ²⁵ or -S (O) _t (R ²⁵ ) = NR ^25a ,
R ^16a represents a hydrogen atom, a fluorine atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ alkylthio or C ₁ -C ₂ alkylsulfinyl,
R ^16b represents a hydrogen atom or a fluorine atom,
R ¹⁷ represents a hydrogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₂ alkoxycarbonyl,
R ¹⁸ represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ²³ is C ₁ -C ₂ alkyl, cyano (C ₁ -C ₂ ) alkyl, -C (O) R ³¹ , -C (O) OR ³² , -C (O) SR ³² or C ₁ -C ₂ Represents alkylsulfonyl,
R ²⁴ represents a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkylcarbonyl, C ₁ -C ₂ alkoxycarbonyl or C ₁ -C ₂ alkylsulfonyl,
R ²⁵ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyanomethyl;
R ^25a represents a hydrogen atom or C ₁ -C ₂ haloalkylcarbonyl,
R ²⁸ represents a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyclopropylmethyl,
R ²⁹ represents a hydrogen atom or C ₁ -C ₂ alkyl,
R ³¹ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or C ₃ -C ₄ cycloalkyl,
R ³² represents C ₁ -C ₂ alkyl,
n represents an integer of 1 or 2,
p1 represents an integer of 1 to 3,
p2 represents an integer of 0 to 2,
p3 and p4 represent an integer of 0 or 1,
q6 represents 0,
r represents an integer of 1 or 2,
t represents an integer of 0 or 1. ]
The substituted benzaldoxime compound or its salt represented by these.

[9] L represents —CH (R ⁴ ) —,
Y is a hydrogen atom, a halogen atom, cyano, nitro, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl, C ₂ -C ₃ alkynyl, C ₁ -C ₂ haloalkoxy or -C (S) NH ₂ Represent,
R ¹ represents -C (O) R ^1a , -C (O) SR ^1b , -C (O) N (R ^1d ) R ^1c or -C (S) R ^1a ,
R ^1a is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , -C (R ¹⁶ ) (R ^16a ) -S (O) _r- R ²⁵ , C ₃ -C ₄ cycloalkyl, E-6, E-7, C ₂ -C ₄ alkenyl, C ₂ -C ₄ haloalkenyl, C ₂ -C ₄ alkynyl, phenyl substituted by (Z) _p1 Or D-53,
R ^1b represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ^1c represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ cycloalkyl or C ₃ -C ₄ alkynyl,
R ^1d represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ² represents a hydrogen atom, C ₁ -C ₄ alkyl, (C ₁ -C ₂ ) alkyl substituted by R ^15a , C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ⁴ represents a hydrogen atom, cyano, methyl, ethynyl or —C (S) NH ₂ ;
Z represents a halogen atom, cyano or nitro, and when p1 and p2 represent an integer of 2 or more, each Z may be the same as or different from each other;
R ¹⁵ represents C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or -C (O) N (R ²⁹ ) R ²⁸ ,
R ^15a represents cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or C ₁ -C ₂ alkoxycarbonyl,
R ¹⁶ represents a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ alkylthio or C ₁ -C ₂ alkylsulfinyl,
R ^16a represents a hydrogen atom,
R ²³ represents cyano (C ₁ -C ₂ ) alkyl, -C (O) R ³¹ or C ₁ -C ₂ alkoxycarbonyl,
R ²⁴ represents a hydrogen atom or C ₁ -C ₂ alkoxycarbonyl,
R ²⁵ represents C ₁ -C ₂ alkyl or C ₁ -C ₂ haloalkyl,
R ²⁸ represents a hydrogen atom or C ₁ -C ₂ alkyl,
The substituted benzaldoxime compound or a salt thereof according to the above [8], wherein R ³¹ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyclopropyl.

[10] A ¹ represents CY,
A ⁴ represents CH,
Y represents a hydrogen atom, a halogen atom, nitro or methyl,
R ¹ represents -C (O) R ^1a or -C (O) NHR ^1c ,
R ^1a represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, cyclopropylmethyl, cyclopropyl or E-6,
R ^1c represents C ₁ -C ₃ alkyl, C ₁ -C ₃ haloalkyl, cyclopropyl or propargyl,
R ² represents a hydrogen atom, C ₁ -C ₂ alkyl, cyclopropylmethyl, C ₁ -C ₂ alkoxymethyl, cyanomethyl, allyl or propargyl,
R ⁴ represents a substituted benzaldoxime compound or a salt thereof according to the above [9], wherein R ⁴ represents a hydrogen atom, cyano or methyl.

  [11] A pest control agent comprising, as an active ingredient, one or more selected from the substituted isoxazoline compounds and salts thereof described in [1] to [7] above.

  [12] An agrochemical containing one or more selected from the substituted isoxazoline compounds according to the above [1] to [7] and salts thereof as an active ingredient.

  [13] A mammal or avian internal or ectoparasite control agent comprising one or more selected from the substituted isoxazoline compounds and salts thereof according to the above [1] to [7] as active ingredients.

  [14] An insecticide or acaricide containing, as an active ingredient, one or more selected from the substituted isoxazoline compounds and salts thereof described in [1] to [7] above.

  The compound of the present invention has excellent insecticidal / miticidal activity against many agricultural pests, spider mites, mammals or birds' internal or ectoparasites, and has acquired resistance against existing insecticides. Even against this, it exhibits a sufficient control effect. Furthermore, it has little adverse effect on mammals, fish and beneficial insects, has low persistence, and has a light environmental impact.

  Therefore, the present invention can provide a useful novel pest control agent.

  The active compounds used as the pest control agents in the present invention are the compounds represented by the above [1] to [7], and the compounds represented by the above [8] to [10] are usually those active compounds. It is a novel production intermediate used for production.

  The compounds encompassed by the present invention may have geometrical isomers of E-form and Z-form depending on the type of substituent, but the present invention is not limited to these E-form, Z-form or E-form. And a mixture containing the Z-form in an arbitrary ratio. In addition, the compounds included in the present invention include optically active substances resulting from the presence of one or more asymmetric carbon atoms, but the present invention includes all optically active substances or racemates.

  Among the compounds included in the present invention, those that can be converted into acid addition salts according to a conventional method include, for example, hydrohalic acids such as hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, and the like. Salt of inorganic acid such as salt, nitric acid, sulfuric acid, phosphoric acid, chloric acid, perchloric acid, salt of sulfonic acid such as methanesulfonic acid, ethanesulfonic acid, trifluoromethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, Salt of carboxylic acid such as formic acid, acetic acid, propionic acid, trifluoroacetic acid, fumaric acid, tartaric acid, succinic acid, maleic acid, malic acid, succinic acid, benzoic acid, mandelic acid, ascorbic acid, lactic acid, gluconic acid, citric acid or the like A salt of an amino acid such as glutamic acid or aspartic acid can be used.

  Alternatively, among the compounds included in the present invention, those that can be converted into a metal salt according to a conventional method include, for example, alkali metal salts such as lithium, sodium, and potassium, and alkaline earth metals such as calcium, barium, and magnesium. It can be a salt or a salt of aluminum.

  Next, specific examples of each substituent shown in the present specification are shown below. Here, n- represents normal, i- represents iso, s- represents secondary, tert- represents tertiary, and Ph represents phenyl.

  As a halogen atom in this invention compound, a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom are mentioned. In the present specification, the notation “halo” also represents these halogen atoms.

The notation of C _a -C _b alkyl in the present specification represents a linear or branched hydrocarbon group composed of _a to _b carbon atoms, for example, a methyl group, an ethyl group, an n-propyl group, i-propyl, n-butyl, i-butyl, s-butyl, tert-butyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 1-ethylpropyl 1,1-dimethylpropyl group, 1,2-dimethylpropyl group, 2,2-dimethylpropyl group, n-hexyl group, 1-methylpentyl group, 2-methylpentyl group, 1,1-dimethylbutyl group, Specific examples include 1,3-dimethylbutyl group, heptyl group, octyl group, nonyl group, decyl group, undecyl group, dodecyl group and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, C _a -C _b haloalkyl is represented by a linear or branched chain consisting of _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. Represents a hydrocarbon group, and when substituted by two or more halogen atoms, the halogen atoms may be the same as or different from each other. For example, fluoromethyl group, chloromethyl group, bromomethyl group, iodomethyl group, difluoromethyl group, chlorofluoromethyl group, dichloromethyl group, bromofluoromethyl group, trifluoromethyl group, chlorodifluoromethyl group, dichlorofluoromethyl group, trichloromethyl Group, bromodifluoromethyl group, bromochlorofluoromethyl group, dibromofluoromethyl group, 2-fluoroethyl group, 2-chloroethyl group, 2-bromoethyl group, 2,2-difluoroethyl group, 2-chloro-2-fluoroethyl Group, 2,2-dichloroethyl group, 2-bromo-2-fluoroethyl group, 2,2,2-trifluoroethyl group, 2-chloro-2,2-difluoroethyl group, 2,2-dichloro-2 -Fluoroethyl group, 2,2,2-trichloroethyl group, 2-bromo-2,2-difluoroethyl group, 2-bromo-2-chloro-2-fluoroethyl group, 2-butyl Lomo-2,2-dichloroethyl group, 1,1,2,2-tetrafluoroethyl group, pentafluoroethyl group, 1-chloro-1,2,2,2-tetrafluoroethyl group, 2-chloro-1 1,2,2-tetrafluoroethyl group, 1,2-dichloro-1,2,2-trifluoroethyl group, 2-bromo-1,1,2,2-tetrafluoroethyl group, 2-fluoropropyl Group, 2-chloropropyl group, 2-bromopropyl group, 2-chloro-2-fluoropropyl group, 2,3-dichloropropyl group, 2-bromo-3-fluoropropyl group, 3-bromo-2-chloropropyl group Group, 2,3-dibromopropyl group, 3,3,3-trifluoropropyl group, 3-bromo-3,3-difluoropropyl group, 2,2,3,3-tetrafluoropropyl group, 2-chloro- 3,3,3-trifluoropropyl group, 2,2,3,3,3-pentafluoropropyl group, 1,1,2,3,3,3-hexafluoropropyl group, heptafluoropropyl group, 2, 3-dichloro-1,1,2,3,3-pentaph Oropropyl group, 2-fluoro-1-methylethyl group, 2-chloro-1-methylethyl group, 2-bromo-1-methylethyl group, 2,2,2-trifluoro-1- (trifluoromethyl) ethyl Groups, 1,2,2,2-tetrafluoro-1- (trifluoromethyl) ethyl group, 2,2,3,3,4,4-hexafluorobutyl group, 2,2,3,4,4, 4-hexafluorobutyl group, 2,2,3,3,4,4,4-heptafluorobutyl group, 1,1,2,2,3,3,4,4-octafluorobutyl group, nonafluorobutyl Group, 4-chloro-1,1,2,2,3,3,4,4-octafluorobutyl group, 2-fluoro-2-methylpropyl group, 2-chloro-1,1-dimethylethyl group, 2 Specific examples include -bromo-1,1-dimethylethyl group, 5-chloro-2,2,3,4,4,5,5-heptafluoropentyl group, tridecafluorohexyl group, etc. In the range of the number of carbon atoms.

In the present specification, C _{a to} C _b cycloalkyl represents a cyclic hydrocarbon group having _a to _b carbon atoms, and forms a monocyclic or complex ring structure having 3 to 6 members. I can do it. Each ring may be optionally substituted with an alkyl group within the range of the specified number of carbon atoms. For example, cyclopropyl group, 1-methylcyclopropyl group, 2-methylcyclopropyl group, 2,2-dimethylcyclopropyl group, 2,2,3,3-tetramethylcyclopropyl group, cyclobutyl group, cyclopentyl group, 2- Specific examples include methylcyclopentyl group, 3-methylcyclopentyl group, cyclohexyl group, 2-methylcyclohexyl group, 3-methylcyclohexyl group, 4-methylcyclohexyl group, bicyclo [2.2.1] heptan-2-yl group, etc. , Each selected range of carbon atoms.

In the present specification, C _a -C _b halocycloalkyl represents a cyclic hydrocarbon group composed of _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. And can form monocyclic or complex ring structures from 3 to 6-membered rings. Each ring may be optionally substituted with an alkyl group within the range of the specified number of carbon atoms, and the substitution with a halogen atom may be a ring structure part, a side chain part, They may be both, and when they are substituted by two or more halogen atoms, the halogen atoms may be the same as or different from each other. For example, 1-fluorocyclopropyl group, 1-chlorocyclopropyl group, 1-bromocyclopropyl group, 2,2-difluorocyclopropyl group, 2,2-dichlorocyclopropyl group, 2,2-dibromocyclopropyl group, 2 , 2-Difluoro-1-methylcyclopropyl group, 2,2-dichloro-1-methylcyclopropyl group, 2,2-dibromo-1-methylcyclopropyl group, 1- (trifluoromethyl) cyclopropyl group, 2 Specific examples include 1,2,3,3-tetrafluorocyclobutyl group, 2-chloro-2,3,3-trifluorocyclobutyl group, and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, C _a -C _b alkenyl is a linear or branched chain composed of _a to _b carbon atoms and has one or more double bonds in the molecule. Represents a saturated hydrocarbon group, for example, vinyl group, 1-propenyl group, 2-propenyl group, 1-methylethenyl group, 2-butenyl group, 1-methyl-2-propenyl group, 2-methyl-2-propenyl group, 2 -Pentenyl group, 2-methyl-2-butenyl group, 3-methyl-2-butenyl group, 2-ethyl-2-propenyl group, 1,1-dimethyl-2-propenyl group, 2-hexenyl group, 2-methyl Specific examples include 2-pentenyl group, 2,4-dimethyl-2,6-heptadienyl group, 3,7-dimethyl-2,6-octadienyl group, etc. Is done.

In the present specification, C _a -C _b haloalkenyl is a linear or branched chain consisting of _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. And an unsaturated hydrocarbon group having one or more double bonds in the molecule. At this time, when substituted with two or more halogen atoms, the halogen atoms may be the same as or different from each other. For example, 2,2-dichlorovinyl group, 2-fluoro-2-propenyl group, 2-chloro-2-propenyl group, 3-chloro-2-propenyl group, 2-bromo-2-propenyl group, 3-bromo-2 -Propenyl group, 3,3-difluoro-2-propenyl group, 2,3-dichloro-2-propenyl group, 3,3-dichloro-2-propenyl group, 2,3-dibromo-2-propenyl group, 2, 3,3-trifluoro-2-propenyl group, 2,3,3-trichloro-2-propenyl group, 1- (trifluoromethyl) ethenyl group, 3-chloro-2-butenyl group, 3-bromo-2- Butenyl group, 4,4-difluoro-3-butenyl group, 3,4,4-trifluoro-3-butenyl group, 3-chloro-4,4,4-trifluoro-2-butenyl group, 3-bromo- A 2-methyl-2-propenyl group or the like is given as a specific example, and is selected within the range of each designated number of carbon atoms.

In the present specification, C _a -C _b cycloalkenyl represents a cyclic unsaturated hydrocarbon group having 1 to 2 carbon atoms and having 1 to 2 carbon atoms. A monocyclic or complex ring structure from a member ring to a 6-member ring can be formed. Each ring may be optionally substituted with an alkyl group within the range of the specified number of carbon atoms, and the double bond may be either endo- or exo-. For example, 1-cyclopentenyl group, 2-cyclopentenyl group, 1-cyclohexenyl group, 2-cyclohexenyl group, bicyclo [2.2.1] -5-hepten-2-yl group and the like can be mentioned as specific examples. Selected within the specified number of carbon atoms.

In the present specification, C _a -C _b halocycloalkenyl is a cyclic and one carbon atom having _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. Alternatively, it represents an unsaturated hydrocarbon group having two or more double bonds, and can form a monocyclic or complex ring structure having 3 to 6 members. Each ring may be optionally substituted with an alkyl group within the range of the specified number of carbon atoms, and the double bond may be either endo- or exo-. In addition, the substitution by a halogen atom may be a ring structure part, a side chain part or both of them, and when substituted by two or more halogen atoms, those halogen atoms May be the same as or different from each other. Specific examples include 2-fluoro-1-cyclopentenyl group, 2-chloro-1-cyclopentenyl group, 3-chloro-2-cyclopentenyl group, 2-fluoro-1-cyclohexenyl group, etc. Selected within the specified number of carbon atoms.

In the present specification, C _a -C _b alkylidene represents a linear or branched hydrocarbon group composed of _a to _b carbon atoms and bonded by a double bond, such as a methylidene group or an ethylidene group. Specific examples include a group, a propylidene group, a 1-methylethylidene group, and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, C _a -C _b alkynyl is a linear or branched chain consisting of _a to _b carbon atoms, and has one or more triple bonds in the molecule. Represents a hydrocarbon group, for example, ethynyl group, 1-propynyl group, 2-propynyl group, 2-butynyl group, 1-methyl-2-propynyl group, 2-pentynyl group, 1-methyl-2-butynyl group, 1, Specific examples include a 1-dimethyl-2-propynyl group, a 2-hexynyl group, and the like, and each is selected within the specified number of carbon atoms.

In the present specification, C _a -C _b haloalkynyl represents a linear or branched chain having _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. And an unsaturated hydrocarbon group having one or more triple bonds in the molecule. At this time, when substituted by two or more halogen atoms, the halogen atoms may be the same as or different from each other. Specific examples include 2-chloroethynyl group, 2-bromoethynyl group, 2-iodoethynyl group, 3-chloro-2-propynyl group, 3-bromo-2-propynyl group, 3-iodo-2-propynyl group and the like. Each of which is selected for each specified number of carbon atoms.

The notation of C _a -C _b alkoxy in the present specification represents an alkyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methoxy group, ethoxy group, n-propyloxy group, Specific examples include i-propyloxy group, n-butyloxy group, i-butyloxy group, s-butyloxy group, tert-butyloxy group, n-pentyloxy group, n-hexyloxy group, etc. It is selected in the range of the number of atoms.

The notation of C _a -C _b haloalkoxy in the present specification represents a haloalkyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, difluoromethoxy group, trifluoromethoxy group, chlorodifluoro Methoxy group, bromodifluoromethoxy group, 2-fluoroethoxy group, 2-chloroethoxy group, 2,2,2-trifluoroethoxy group, 1,1,2,2, -tetrafluoroethoxy group, 2-chloro-1 , 1,2-trifluoroethoxy group, 2-bromo-1,1,2-trifluoroethoxy group, pentafluoroethoxy group, 2,2-dichloro-1,1,2-trifluoroethoxy group, 2,2 , 2-trichloro-1,1-difluoroethoxy group, 2-bromo-1,1,2,2-tetrafluoroethoxy group, 2,2,3,3-tetrafluoropropyloxy group, 1,1,2, 3,3,3-hexafluoropropyloxy group, 2,2,2-trifluoro-1- (trifluoromethyl) ethoxy group, Data fluoropropyl group, 2-bromo-1,1,2,3,3,3-hexafluoro-propyloxy group, etc. As a specific example, may be selected from the range of the specified number of carbon atoms.

The notation of C _a -C _b alkenyloxy in the present specification represents an alkenyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, 2-propenyloxy group, 2-butenyloxy group, Specific examples include 2-methyl-2-propenyloxy group, 3-methyl-2-butenyloxy group and the like, and each is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylthio in the present specification represents an alkyl-S-group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylthio group, ethylthio group, n-propylthio group, i Specific examples include -propylthio group, n-butylthio group, i-butylthio group, s-butylthio group, tert-butylthio group, n-pentylthio group, n-hexylthio group, etc. Selected.

The notation of C _a -C _b haloalkylthio in the present specification represents a haloalkyl-S— group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, difluoromethylthio group, trifluoromethylthio group, chlorodifluoro Methylthio group, bromodifluoromethylthio group, 2,2,2-trifluoroethylthio group, 1,1,2,2-tetrafluoroethylthio group, 2-chloro-1,1,2-trifluoroethylthio group, Pentafluoroethylthio group, 2-bromo-1,1,2,2-tetrafluoroethylthio group, 1,1,2,3,3,3-hexafluoropropylthio group, heptafluoropropylthio group, 1, Specific examples include 2,2,2-tetrafluoro-1- (trifluoromethyl) ethylthio group, nonafluorobutylthio group and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, the notation of C _a -C _b alkylsulfinyl represents an alkyl-S (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylsulfinyl group, ethylsulfinyl group, Specific examples include n-propylsulfinyl group, i-propylsulfinyl group, n-butylsulfinyl group, i-butylsulfinyl group, s-butylsulfinyl group, tert-butylsulfinyl group and the like. The range is selected.

In the present specification, the expression C _a -C _b haloalkylsulfinyl represents a haloalkyl-S (O) -group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, difluoromethylsulfinyl group, trifluoromethyl Sulfinyl group, chlorodifluoromethylsulfinyl group, bromodifluoromethylsulfinyl group, 2,2,2-trifluoroethylsulfinyl group, 2-bromo-1,1,2,2-tetrafluoroethylsulfinyl group, 1,2,2 Specific examples include 2-tetrafluoro-1- (trifluoromethyl) ethylsulfinyl group, nonafluorobutylsulfinyl group, and the like, each selected within the range of the specified number of carbon atoms.

The notation of C _a -C _b alkylsulfonyl in the present specification represents an alkyl-S (O) ₂ -group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylsulfonyl group, ethylsulfonyl group N-propylsulfonyl group, i-propylsulfonyl group, n-butylsulfonyl group, i-butylsulfonyl group, s-butylsulfonyl group, tert-butylsulfonyl group, n-pentylsulfonyl group, n-hexylsulfonyl group, etc. Specific examples are given, each selected in the range of the specified number of carbon atoms.

The notation of C _a -C _b haloalkylsulfonyl in the present specification represents a haloalkyl-S (O) ₂ -group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a difluoromethylsulfonyl group, trifluoro Methylsulfonyl group, chlorodifluoromethylsulfonyl group, bromodifluoromethylsulfonyl group, 2,2,2-trifluoroethylsulfonyl group, 1,1,2,2-tetrafluoroethylsulfonyl group, 2-chloro-1,1, Specific examples include 2-trifluoroethylsulfonyl group, 2-bromo-1,1,2,2-tetrafluoroethylsulfonyl group, and the like, and each is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylamino in the present specification represents an amino group in which one of the hydrogen atoms is substituted with an alkyl group having the above meaning consisting of _a to _b carbon atoms, for example, a methylamino group , Ethylamino group, n-propylamino group, i-propylamino group, n-butylamino group, i-butylamino group, tert-butylamino group and the like. Selected by range.

In the present specification, the notation of di (C _a -C _b alkyl) amino has the above-mentioned meaning that the number of carbon atoms, both of which are the same or different from each other, may be the same or different from each other. Represents an amino group substituted by an alkyl group, such as dimethylamino group, ethyl (methyl) amino group, diethylamino group, n-propyl (methyl) amino group, i-propyl (methyl) amino group, di (n-propyl) Specific examples include amino group, n-butyl (methyl) amino group, i-butyl (methyl) amino group, tert-butyl (methyl) amino group, etc., each selected within the range of the specified number of carbon atoms. .

The notation of C _a -C _b alkylimino in the present specification represents an alkyl-N = group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylimino group, ethylimino group, n-propylimino group. Specific examples include i-propylimino group, n-butylimino group, i-butylimino group, s-butylimino group and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, the expression C _a -C _b alkoxyimino represents an alkoxy-N = group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a methoxyimino group, an ethoxyimino group, and n-propyl. Specific examples include an oxyimino group, an i-propyloxyimino group, an n-butyloxyimino group, and the like, and each is selected in the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylcarbonyl in the present specification represents an alkyl-C (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, acetyl group, propionyl group, butyryl group. Specific examples thereof include isobutyryl group, valeryl group, isovaleryl group, 2-methylbutanoyl group, pivaloyl group, hexanoyl group, heptanoyl group and the like, and each is selected in the range of the designated number of carbon atoms.

The notation of C _a -C _b haloalkylcarbonyl in the present specification represents a haloalkyl-C (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a fluoroacetyl group, a chloroacetyl group, Difluoroacetyl group, dichloroacetyl group, trifluoroacetyl group, chlorodifluoroacetyl group, bromodifluoroacetyl group, trichloroacetyl group, pentafluoropropionyl group, heptafluorobutanoyl group, 3-chloro-2,2-dimethylpropanoyl group Etc. are given as specific examples, and each is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkoxycarbonyl in the present specification represents an alkyl-OC (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a methoxycarbonyl group, an ethoxycarbonyl group, Specific examples include n-propyloxycarbonyl group, i-propyloxycarbonyl group, n-butoxycarbonyl group, i-butoxycarbonyl group, tert-butoxycarbonyl group, etc., selected within the range of each designated number of carbon atoms Is done.

The notation of C _a -C _b haloalkoxycarbonyl in the present specification represents a haloalkyl-OC (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a 2-chloroethoxycarbonyl group, Specific examples include 2,2-difluoroethoxycarbonyl group, 2,2,2-trifluoroethoxycarbonyl group, 2,2,2-trichloroethoxycarbonyl group, etc., each selected within the range of the specified number of carbon atoms Is done.

The notation of C _a -C _b alkylaminocarbonyl in the present specification represents a carbamoyl group in which one of the hydrogen atoms is substituted with an alkyl group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylcarbamoyl Group, ethylcarbamoyl group, n-propylcarbamoyl group, i-propylcarbamoyl group, n-butylcarbamoyl group, i-butylcarbamoyl group, s-butylcarbamoyl group, tert-butylcarbamoyl group, etc. Is selected within the range of the specified number of carbon atoms.

In the present specification, the expression C _a -C _b haloalkylaminocarbonyl represents a carbamoyl group in which one of the hydrogen atoms is substituted with a haloalkyl group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as 2-fluoro Specific examples include ethylcarbamoyl group, 2-chloroethylcarbamoyl group, 2,2-difluoroethylcarbamoyl group, 2,2,2-trifluoroethylcarbamoyl group, etc., selected within the range of each specified number of carbon atoms Is done.

In the present specification, the notation of di (C _a -C _b alkyl) aminocarbonyl means in the above-mentioned meaning that the number of carbon atoms, which may be both the same or different from each other, consists of _a to _b carbon atoms. Represents a carbamoyl group substituted by an alkyl group, for example, N, N-dimethylcarbamoyl group, N-ethyl-N-methylcarbamoyl group, N, N-diethylcarbamoyl group, N, N-di-n-propylcarbamoyl group Specific examples include N, N-di-n-butylcarbamoyl group and the like, and each is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylaminosulfonyl in the present specification represents a sulfamoyl group in which one of the hydrogen atoms is substituted with an alkyl group having the above-mentioned meaning consisting of _a to _b carbon atoms. Famoyl group, ethylsulfamoyl group, n-propylsulfamoyl group, i-propylsulfamoyl group, n-butylsulfamoyl group, i-butylsulfamoyl group, s-butylsulfamoyl group, Specific examples include a tert-butylsulfamoyl group and the like, which are selected in the range of each designated number of carbon atoms.

In the present specification, the notation of di (C _a -C _b alkyl) aminosulfonyl means in the above meaning that the number of carbon atoms that may be the same or different from each other is _a to _b. Represents a sulfamoyl group substituted by an alkyl group, such as N, N-dimethylsulfamoyl group, N-ethyl-N-methylsulfamoyl group, N, N-diethylsulfamoyl group, N, N-di- Specific examples include -n-propylsulfamoyl group, N, N-di-n-butylsulfamoyl group and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, the notation of tri (C _a -C _b alkyl) silyl is substituted with an alkyl group having the above-mentioned meanings each having the same or different number of carbon atoms from _a to _b . Represents a silyl group, for example, trimethylsilyl group, triethylsilyl group, tri (n-propyl) silyl group, ethyldimethylsilyl group, n-propyldimethylsilyl group, n-butyldimethylsilyl group, i-butyldimethylsilyl group, tert- Specific examples include a butyldimethylsilyl group and the like, and each butyldimethylsilyl group is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylsulfonyloxy in the present specification represents an alkylsulfonyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylsulfonyloxy group, ethylsulfonyloxy group Specific examples include an n-propylsulfonyloxy group, an i-propylsulfonyloxy group, and the like, and each is selected within the specified number of carbon atoms.

The notation of C _a -C _b haloalkylsulfonyloxy in the present specification represents a haloalkylsulfonyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, difluoromethylsulfonyloxy group, trifluoromethyl Specific examples include a sulfonyloxy group, a chlorodifluoromethylsulfonyloxy group, a bromodifluoromethylsulfonyloxy group, and the like, and each is selected within the range of the designated number of carbon atoms.

C _a -C _b cycloalkyl (C _d -C _e ) alkyl, hydroxy (C _d -C _e ) alkyl, C _a -C _b alkoxy (C _d -C _e ) alkyl, C _a -C _b herein Haloalkoxy (C _d -C _e ) alkyl, C _a -C _b alkylthio (C _d -C _e ) alkyl, C _a -C _b haloalkylthio (C _d -C _e ) alkyl, C _a -C _b alkylsulfinyl ( C _d -C _e ) alkyl, C _a -C _b haloalkylsulfinyl (C _d -C _e ) alkyl, C _a -C _b alkylsulfonyl (C _d -C _e ) alkyl, C _a -C _b haloalkylsulfonyl (C _d -C _e) alkyl, cyano (C _d ~C _e) alkyl, C _a -C _b alkoxycarbonyl (C _d ~C _e) alkyl, C _a -C _b haloalkoxycarbonyl (C _d ~C _e) alkyl, phenyl (C _d ~C _e) alkyl or (Z) _p1 notation such as phenyl (C _d ~C _e) alkyl substituted by the optional C _a -C _b are the respective meanings Black alkyl group, C _a -C _b alkoxy group, C _a -C _b haloalkoxy group, C _a -C _b alkylthio group, C _a -C _b haloalkylthio group, C _a -C _b alkylsulfinyl group, C _a ~ C _b haloalkylsulfinyl group, C _a -C _b alkylsulfonyl group, C _a -C _b haloalkylsulfonyl group, C _a -C _b alkoxycarbonyl group, C _a -C _b haloalkoxycarbonyl group, hydroxyl group, cyano group, phenyl group Or (Z) an alkyl group having the above-mentioned meaning consisting of d to e, wherein the hydrogen atom bonded to the carbon atom is substituted by a phenyl group substituted by _p1 , and each designated carbon atom Selected in a range of numbers.

Optionally substituted by R ⁵ in this specification (C _a ~C _b) alkyl, optionally substituted by R ¹⁵ (C _a ~C _b) alkyl, optionally substituted by R ^15a (C _^a ~ C _b) alkyl, optionally substituted by R ²² (C _a ~C _b) alkyl, optionally substituted by R ³⁰ (C _a ~C _b) optionally substituted by alkyl or R ³⁵ (C _a -C _b) notation alkyl or the like, any of ^{R 5, R 15, R 15a} , by R ^22, R ³⁰ or R ^35, the carbon atoms bonded to hydrogen atoms are optionally substituted carbon atoms a~ It represents an alkyl group as defined above consisting of b, and is selected within the range of the number of carbon atoms specified. At this time, when two or more substituents R ⁵ , R ¹⁵ , R ^15a , R ²² , R ³⁰ or R ³⁵ on each (C _a -C _b ) alkyl group are present, each R ⁵ , R ¹⁵ , R ^15a , R ²² , R ³⁰ or R ³⁵ may be the same as or different from each other.

In the present specification, the notation of hydroxy (C _d -C _e ) haloalkyl, C _a -C _b alkoxy (C _d -C _e ) haloalkyl or C _a -C _b haloalkoxy (C _d -C _e ) haloalkyl is as described above. The number of carbon atoms in which a hydrogen atom or a halogen atom bonded to a carbon atom is substituted by any C _a -C _b alkoxy group, C _a -C _b haloalkoxy group or hydroxyl group, Are selected within the range of each specified number of carbon atoms.

Hydroxy herein (C _d ~C _e) cycloalkyl, C _a -C _b alkoxy (C _d ~C _e) cycloalkyl, cyano (C _d ~C _e) cycloalkyl or phenyl (C _d ~C _e) The notation such as cycloalkyl represents the number of carbon atoms in which a hydrogen atom bonded to a carbon atom is arbitrarily substituted by any C _a -C _b alkoxy group, cyano group, hydroxyl group or phenyl group, each having the above-mentioned meaning. It represents a cycloalkyl group having the above meaning consisting of ˜e, and is selected in the range of each designated number of carbon atoms.

Optionally substituted by R ⁵ in this specification (C _a ~C _b) cycloalkyl, optionally substituted by R ¹⁵ (C _a ~C _b) cycloalkyl, optionally substituted by R ²² (C _a -C _b) optionally substituted by cycloalkyl or R ³⁰ (C _{a ~C b)} notation cycloalkyl or the like, by any R ^5, R ^15, R ²² or R ^30, bonded to a carbon atom It represents a cycloalkyl group having the above-mentioned meaning consisting of a to b carbon atoms in which hydrogen atoms are optionally substituted, and each is selected within the range of the designated number of carbon atoms. At this time, the substitution by R ⁵ , R ¹⁵ , R ²² or R ³⁰ may be a ring structure part, a side chain part or both of them, and each (C _{a to} C _b ) when two or more substituents R ⁵ , R ¹⁵ , R ²² or R ³⁰ on the cycloalkyl group are present, each R ⁵ , R ¹⁵ , R ²² or R ³⁰ may be identical to each other, or They may be different from each other.

Optionally substituted by R ⁵ in this specification (C _a ~C _b) alkenyl, optionally substituted by R ¹⁵ (C _a ~C _b) alkenyl, optionally substituted by R ²² (C _a ~ C _b ) alkenyl or (C _a -C _b ) alkenyl optionally substituted by R ³⁰ may be represented by any R ⁵ , R ¹⁵ , R ²² or R ³⁰ , and optionally a hydrogen atom bonded to a carbon atom. It represents an alkenyl group having the above-mentioned meaning, wherein the number of substituted carbon atoms consists of a to b, and is selected within the range of each designated number of carbon atoms. At this time, when there are two or more substituents R ⁵ , R ¹⁵ , R ²² or R ³⁰ on each (C _a -C _b ) alkenyl group, each R ⁵ , R ¹⁵ , R ²² or R ^{30 is present.} May be the same as or different from each other.

Optionally substituted by R ⁵ in this specification (C _a ~C _b) alkynyl, optionally substituted by R ¹⁵ (C _a ~C _b) alkynyl, optionally substituted by R ²² (C _a ~ C _b ) Alkynyl or optionally substituted by R ³⁰ (C _a -C _b ) alkynyl is notated by any R ⁵ , R ¹⁵ , R ²² or R ³⁰ , optionally hydrogen atoms attached to carbon atoms It represents an alkynyl group having the above meaning consisting of a to b substituted carbon atoms, and is selected in the range of each designated number of carbon atoms. At this time, when two or more substituents R ⁵ , R ¹⁵ , R ²² or R ³⁰ on each (C _a -C _b ) alkynyl group are present, each R ⁵ , R ¹⁵ , R ²² or R ^{30 is present.} May be the same as or different from each other.

In this specification
[R ^1d represents that a C _{2 to} C ₆ alkylene chain may be formed together with R ^1c to form a 3- to 7-membered ring with the nitrogen atom to which R ^1c and R ^1d are bonded; In this case, the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and may be optionally substituted with an oxo group or a thioxo group.
[R ² represents that together with R ¹ , a C _{4 to} C ₆ alkylene chain may be formed to form a 5- to 7-membered ring with the nitrogen atom to which R ¹ and R ² are bonded; In this case, the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and may be optionally substituted with an oxo group or a thioxo group.
[R ⁸ represents that R ⁷ together with R ⁷ may form a C ₂ -C ₆ alkylene chain to form a 3- to 7-membered ring with the nitrogen atom to which R ⁷ and R ⁸ are bonded; In this case, the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and may be optionally substituted with an oxo group or a thioxo group.
as well as
[R ²⁴ represents that by forming C ₂ -C ₅ alkylene chain together with R ^23, may form a 3- to 6-membered ring together with the nitrogen atom to which R ²³ and R ²⁴ are bonded, At this time, the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and may be optionally substituted with an oxo group or a thioxo group.]
Specific examples of notations such as aziridine, azetidine, azetidin-2-one, pyrrolidine, pyrrolidin-2-one, oxazolidine, oxazolidine-2-one, oxazolidine-2-thione, thiazolidine, thiazolidine-2-one, thiazolidine -2-thione, imidazolidine, imidazolidine-2-one, imidazolidine-2-thione, piperidine, piperidin-2-one, piperidine-2-thione, 2H-3,4,5,6-tetrahydro-1, 3-Oxazin-2-one, 2H-3,4,5,6-tetrahydro-1,3-oxazine-2-thione, morpholine, 2H-3,4,5,6-tetrahydro-1,3-thiazine 2-one, 2H-3,4,5,6-tetrahydro-1,3-thiazine-2-thione, thiomorpholine, thiomorpholine-1-oxide, thiomorpholine-1,1-dioxide, perhydropyrimidine-2 -On, piperazine, homopiperidine, homopiperidin-2-one, heptamethy N'imin and the like, may be selected from the range number of each of the specified atoms.

In this specification
[R ^4a represents that, together with R ⁴ , a C ₂ -C ₅ alkylene chain may be formed to form a 3- to 6-membered ring with the carbon atom to which R ⁴ and R ^4a are bonded; At this time, the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom.]
Specific examples of the notation include, for example, cyclopropane ring, cyclobutane ring, cyclopentane ring, tetrahydrofuran ring, tetrahydrothiophene ring, pyrrolidine ring, cyclohexane ring, tetrahydropyran ring, tetrahydrothiopyran ring, piperidine ring, cycloheptane ring, oxepane ring , Thiepan ring, azepan ring and the like, and each is selected within the range of the designated number of atoms.

In this specification
[R ^8a represents that together with R ^7a , a C ₄ -C ₆ alkylene chain is formed to form a 5- to 7-membered ring together with the carbon atom to which R ^7a and R ^8a are bonded; At this time, the alkylene chain may contain one oxygen atom or one sulfur atom.]
Specific examples of the notation include, for example, cyclopentylidene, tetrahydrofuran-3-ylidene, tetrahydrothiophene-3-ylidene, cyclohexylidene, tetrahydropyran-3-ylidene, tetrahydropyran-4-ylidene, tetrahydrothiopyran-3-ylidene , Tetrahydrothiopyran-4-ylidene, and the like, each selected within a range of the specified number of atoms.

In this specification
[R ¹² represents that by forming C ₂ -C ₆ alkylene chain together with R ^11, may form a 3- to 7-membered ring together with the nitrogen atom to which R ¹¹ and R ¹² are bonded, At this time, the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom.]
[R ¹⁸ represents that R ¹⁷ together with R ¹⁷ may form a C ₂ -C ₆ alkylene chain to form a 3- to 7-membered ring with the nitrogen atom to which R ¹⁷ and R ¹⁸ are bonded; At this time, the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom.]
[R ^18a represents that by forming a C ₄ -C ₇ alkylene chain together with R ^17a, may form a 5- to 8-membered ring together with the nitrogen atom to which R ^17a and R ^18a are attached, At this time, the alkylene chain may contain one oxygen atom or sulfur atom,
[R ²⁹ represents that R ²⁸ and R ²⁸ may form a C ₂ -C ₅ alkylene chain to form a 3- to 6-membered ring together with the nitrogen atom to which R ²⁸ and R ²⁹ are bonded; At this time, the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and may be optionally substituted with an oxo group.]
as well as
[R ³⁴ represents that R 3 and R ³³ may form a C _{2 to} C ₅ alkylene chain to form a 3 to 6 membered ring with the nitrogen atom to which R ³³ and R ³⁴ are bonded; At this time, the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom.]
Specific examples of notation such as aziridine, azetidine, pyrrolidine, oxazolidine, thiazolidine, imidazolidine, piperidine, morpholine, thiomorpholine, thiomorpholine-1-oxide, thiomorpholine-1,1-dioxide, piperazine, homopiperidine, Heptamethyleneimine and the like can be mentioned, and each is selected within the range of the designated number of atoms.

In the compounds included in the present invention, examples of combinations of atoms represented by A ¹ , A ² , A ³ and A ⁴ include the following groups.

That is, AI: A ¹ is CY, A ² , A ³ and A ⁴ are CH.

A-II: A ¹ is CY, A ² and A ³ are CH, and A ⁴ is N.

A-III: A ¹ is CY, A ² and A ⁴ are CH, and A ³ is N.

A-IV: A ¹ is CY, A ² is N, A ³ and A ⁴ are CH.

AV: A ¹ is N, A ² , A ³ and A ⁴ are CH.

A-VI: A ¹ is CY, A ² and A ³ are N, and A ⁴ is CH.

A-VII: A ¹ is CY, A ² and A ⁴ are N, and A ³ is CH.

A-VIII: A ¹ is CY, A ³ and A ⁴ are N, and A ² is CH.

A-IX: A ¹ and A ⁴ are N, A ² and A ³ are CH.

AX: A ¹ , A ² , A ³ and A ⁴ are CY or N.

Of these, AI, A-II, A-III, A-IV and AV are more preferred as the combination of atoms represented by A ¹ , A ² , A ³ and A ⁴ , and further AI and A-II Is particularly preferred.

  In the compounds included in the present invention, examples of the substituent represented by G include 6-membered aromatic rings such as benzene ring, pyridine ring, pyrimidine ring, pyrazine ring and pyridazine ring, furan ring, thiophene ring and isoxazole ring. Aromatic 5-membered rings such as pyrazole ring, thiazole ring and imidazole ring, among which 6-aromatic rings represented by G-1, G-3 and G-4 and G- An aromatic 5-membered ring represented by 13, G-14, G-17, G-18, G-20, G-21 and G-22 is preferred, and a benzene ring represented by G-1 is particularly preferred. preferable.

  In the compounds included in the present invention, examples of the preferred range of the substituent represented by L include the following groups.

That is, LI: —CH (R ⁴ ) — [where R ⁴ represents a hydrogen atom, cyano or methyl. ].

L-II: —CH (R ⁴ ) — [wherein R ⁴ represents a hydrogen atom, cyano, methyl, ethynyl or —C (S) NH ₂ . ].

L-III: -C (R ⁴ ) (R ^4a )-[where R ⁴ represents a hydrogen atom, cyano, methyl, trifluoromethyl, ethynyl or -C (S) NH ₂ , and R ^4a represents a hydrogen atom Represents. ].

L-IV: -C (R ⁴ ) (R ^4a )-[where R ⁴ and R ^4a together form an ethylene chain to form a cyclohexane together with the carbon atom to which R ⁴ and R ^4a are bonded. It represents forming a propyl ring. ].

LV: -C (R ⁴ ) (R ^4a )-[where R ⁴ is a hydrogen atom, cyano, C ₁ -C ₃ alkyl, C ₁ -C ₃ haloalkyl, C ₃ -C ₄ cycloalkyl, C _2- C ₃ alkynyl, —C (O) NH ₂ , —C (S) NH ₂ , phenyl, D-18 or D-21, R ^4a represents a hydrogen atom, and p4 represents 0. ].

L-VI: -C (R ⁴ ) (R ^4a )-[where R ⁴ represents cyano or C ₁ -C ₃ alkyl, R ^4a represents C ₁ -C ₃ alkyl, or R ⁴ And R ^4a may form an ethylene chain to form a cyclopropyl ring together with the carbon atom to which R ⁴ and R ^4a are bonded. ].

L-VII: —C (R ⁴ ) (R ^4a ) CH ₂ — [wherein R ⁴ represents a hydrogen atom, methyl, cyano or —C (S) NH ₂ , and R ^4a represents a hydrogen atom. ].

L-VIII: -N (R ^4b )-and -C (R ⁴ ) (R ^4a ) N (R ^4b )-[where R ⁴ represents a hydrogen atom or methyl, R ^4a represents a hydrogen atom, R ^4b represents a hydrogen atom, C ₁ -C ₃ alkyl, C ₁ -C ₃ alkylcarbonyl, C ₃ -C ₄ cycloalkylcarbonyl or C ₁ -C ₃ alkoxycarbonyl. ].

  Among these, the preferred range of the substituent represented by L is more preferably L-I, L-II, L-III, L-IV and L-V, and particularly preferably L-I and L-II.

  In the compounds included in the present invention, examples of the range of the substituent represented by X include the following groups. At this time, when m represents an integer of 2 or more in each of the following cases, each X may be the same as or different from each other.

  That is, X-I: a halogen atom and trifluoromethyl [where m represents an integer of 1 to 3. ].

X-II: halogen atom, cyano, —SF ₅ , C ₁ -C ₂ haloalkyl, C ₁ -C ₂ haloalkoxy and C ₁ -C ₂ haloalkylthio [wherein m represents an integer of 1 to 3. ].

X-III: halogen atom, cyano, nitro, -SF _5, C ₁ ~C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ alkylthio And C ₁ -C ₄ haloalkylthio [wherein m represents an integer of 1 to 3. ].

X-IV: halogen atom, —SF ₅ , C ₁ -C ₆ haloalkyl, hydroxy (C ₁ -C ₄ ) haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) haloalkyl, —OR ⁶ and —S ( O) _r R ⁶ [wherein R ⁶ represents C ₁ -C ₆ haloalkyl or C ₁ -C ₄ haloalkoxy (C ₁ -C ₄ ) haloalkyl, r represents an integer of 0 to 2, and m represents 1 Represents. ].

XV: halogen atoms, cyano, nitro, -SF _5, C ₁ ~C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ ~C ₄₎ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ Haloalkyl, —NH ₂ , —OR ⁶ and —S (O) _r R ^6, wherein R ⁶ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₄ haloalkoxy (C _1- C ₄ ) represents haloalkyl, r represents an integer of 0 to 2, and m represents an integer of 2 or 3. ].

X-VI: m represents 2, two X are adjacent _{-CF 2 OCF 2 -, - OCF} 2 O -, - CF 2 OCF 2 O- or -OCF _{by 2} CF ₂ form O- the , Each forms a 5- or 6-membered ring with the carbon atoms to which they are attached.

  X-VII: 3,5-dichloro.

  In the compounds included in the present invention, examples of the range of the substituent represented by Y include the following groups. At this time, when two or more substituents represented by Y are present simultaneously, each Y may be the same as or different from each other.

  That is, Y-I: a hydrogen atom, a halogen atom, nitro and methyl.

Y-II: hydrogen atom, halogen atom, cyano, nitro, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl, C ₂ -C ₃ alkynyl, C ₁ -C ₂ haloalkoxy, C ₁ -C ₂ haloalkylthio and -C (S) NH _2.

Y-III: hydrogen atom, halogen atom, cyano, nitro, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₂ -C ₄ alkynyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ alkylthio, C ₁ -C ₄ haloalkylthio and -C (S) NH _2.

Y-IV: hydrogen atom, halogen atom, cyano, nitro, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, substituted by R ⁵ (C ₁ ~C ₄₎ alkyl [wherein, R ⁵ is - OH, represents a C ₁ -C ₄ alkoxy, C ₁ -C ₄ alkylthio, C ₁ -C ₄ alkylsulfinyl or C ₁ -C ₄ alkylsulfonyl. ], C ₂ ~C ₆ alkenyl, C ₂ -C ₆ alkynyl, and -C (S) NH _2.

^{YV: -OR 6, -S (O} ) r R 6 [ wherein, R ⁶ represents a C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl, r is an integer of 0 to 2. ] And -N (R ⁸⁾ R ⁷ [wherein, R ⁷ represents a hydrogen atom, C ₁ -C ₆ alkyl, -CHO, a C ₁ -C ₆ alkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl, R ⁸ represents a hydrogen atom or a C ₁ -C ₆ alkyl. ].

  Y-VI: D-1 to D-5, D-14, D-24 and D-41 [wherein p2, p3 and p4 represent 0. ].

In the compounds included in the present invention, examples of the range of the substituent represented by R ¹ include the following groups.

That is, R ¹ -I: —C (O) R ^1a [wherein R ^1a represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, cyclopropylmethyl, cyclopropyl, or E-6, and q 6 represents 0 is represented. ].

R ¹ -II: —C (O) NHR ^1c [wherein R ^1c represents C ₁ -C ₃ alkyl, C ₁ -C ₃ haloalkyl, cyclopropyl or propargyl. ].

R ¹ -III: —C (O) R ^1a and —C (S) R ^1a [wherein R ^1a is substituted with C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, R ¹⁵ (C ₁ -C ₂₎ alkyl, C ₃ -C _{4 cycloalkyl, E-6, C 2 ~C} 4 alkenyl, C ₂ -C ₄ haloalkenyl, C ₂ -C ₄ alkynyl, phenyl or substituted by (Z) _p1 D-53, R ¹⁵ is C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or -C (O) N (R ²⁹ ) R ²⁸ , R ²³ represents cyano (C ₁ -C ₂ ) alkyl, R ²⁴ represents a hydrogen atom or C ₁ -C ₂ alkoxycarbonyl, and R ²⁸ represents a hydrogen atom or C ₁ -C ₂ alkyl. R ²⁹ represents a hydrogen atom or C ₁ -C ₂ alkyl, Z represents a halogen atom, cyano, nitro or C ₁ -C ₄ alkylthio, and when p1 and p2 represent an integer of 2 or more, each Z May be the same as or different from each other p1 represents an integer of 1 to 3, p2 is an integer of 0 to 2, q6 stands for 0, t represents 0. ].

R ¹ -IV: —C (O) SR ^1b [wherein R ^1b represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl. And -C (O) N (R ^1d ) R ^1c [wherein R ^1c is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ cycloalkyl or C ₃ -C ₄ alkynyl. R ^1d represents a hydrogen atom or C ₁ -C ₄ alkyl. ].

R ¹ -V: —C (O) R ^1a and —C (S) R ^1a [where R ^1a is substituted by a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, R ¹⁵ (C ₁ ~C ₂₎ alkyl, C ₃ -C ₄ cycloalkyl, E-5, E-6 , C 2 ~C 4 alkenyl, C ₂ -C ₄ haloalkenyl, C ₂ -C ₄ alkynyl, -CH _{2 ^{CH 2 -R 16, -C (R}} 9) = NOR 10, phenyl substituted by (Z) _p1, represents the D-3, D-17 or D-53, R ¹⁴ is a C ₁ -C ₂ alkyl R ¹⁵ is cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or -C (O) N (R ²⁹ ) R represents ^28, R ⁹ represents a hydrogen atom, R ¹⁰ represents a C ₁ -C ₂ alkyl, R ¹⁶ represents ^{_{-S (O) r R 25,}} R 23 is C ₁ -C ₂ alkyl, cyano ( C ₁ -C ₂₎ alkyl or C ₁ -C ₂ haloalkylcarbonyl, R ²⁴ is a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkylcarbonyl, C ₁ -C ₂ Arukokishikaru Represents alkylsulfonyl or C ₁ -C ₂ alkylsulfonyl, R ²⁵ is C ₁ -C ₂ alkyl, R ²⁸ is a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyclopropylmethyl, R ²⁹ represents a hydrogen atom or C ₁ -C ₂ alkyl, Z represents a halogen atom, cyano, nitro, C ₁ -C ₄ alkyl or C ₁ -C ₄ alkylthio, and p 1 and p 2 represent an integer of 2 or more Each Z may be the same or different from each other, p1 represents an integer of 1 to 3, p2 represents an integer of 0 to 2, and p3 and p4 represent an integer of 0 or 1 Q6 represents 0, and t represents 0. ].

R ¹ -VI: —C (O) OR ^1b and —C (O) SR ^1b [where R ^1b is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ alkenyl, or C ₃ ~C represents a ₄ alkynyl. ].

R ¹ -VII: —C (O) N (R ^1d ) R ^1c and —C (S) N (R ^1d ) R ^1c [where R ^1c is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl. , substituted by R ¹⁵ (C ₁ ~C ₂₎ alkyl, C ₃ -C ₄ cycloalkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ alkynyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ Represents alkylsulfonyl or —N (R ¹⁸ ) R ¹⁷ , R ^1d represents a hydrogen atom or C ₁ -C ₄ alkyl, or R ^1d together with R ^1c represents a C ₄ -C ₅ alkylene chain. And forming a 5- to 6-membered ring together with the nitrogen atom to which R ^1c and R ^1d are bonded, wherein the alkylene chain may contain one oxygen or sulfur atom, and Optionally substituted by a methyl group or an oxo group, R ¹⁵ represents cyano, C ₁ -C ₂ alkoxy or —C (O) N (R ²⁹ ) R ²⁸ , R ¹⁷ represents a hydrogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₂ Arukokishikaru Represents nil, R ¹⁸ represents a hydrogen atom or a C ₁ -C ₄ alkyl, R ²⁸ represents a C ₁ -C ₂ alkyl or C ₁ -C ₂ haloalkyl, R ²⁹ is a hydrogen atom or a C ₁ -C ₂ alkyl Represents. ].

R ¹ -VIII: —C (O) R ^1a and —C (S) R ^1a [wherein R ^1a is substituted by a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, R ¹⁵ (C ₁ ~C ₂₎ alkyl, C ₃ -C ₇ cycloalkyl, C ₃ -C ₆ halocycloalkyl, phenyl (C ₃ ~C ₆₎ cycloalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ halo alkenyl, C ₂ -C ₆ alkynyl or C ₂ -C ₆ haloalkynyl, R ¹⁵ is C ₃ -C ₆ cycloalkyl, C ₅ -C ₆ cycloalkenyl, phenyl, phenyl substituted by (Z) _p1, D-1, D-3, D-21, D-22 or D-52 to D-54, Z represents a halogen atom, and when p1 represents 2, each Z may be the same as each other Alternatively, they may be different from each other, p1 represents an integer of 1 or 2, p2, p3 and p4 represent 0 or an integer of 1, and t represents 0. ].

R ¹ -IX: —C (O) R ^1a and —C (S) R ^1a [where R ^1a is (C ₁ -C ₂ ) alkyl or cyano (C ₃ -C ₆ ) substituted by R ¹⁵ Represents cycloalkyl, R ¹⁵ is cyano, -C (O) OR ²⁷ , -C (O) N (R ²⁹ ) R ²⁸ , -C (S) N (R ²⁹ ) R ²⁸ , -C (= NOH) N (R ²⁹ ) R ²⁸ or -C (= NOR ²⁷ ) N (R ²⁹ ) R ²⁸ , R ²⁷ represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl, R ²⁸ is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ cycloalkyl (C ₁ -C ₂ ) alkyl, C ₃ -C ₆ cycloalkyl or C ₁ -C ₄ haloalkylcarbonyl, R ²⁹ Represents a hydrogen atom or C ₁ -C ₄ alkyl, or R ²⁹ together with R ²⁸ together with the nitrogen atom to which R ²⁸ and R ²⁹ are bonded, by forming a C ₄ -C ₅ alkylene chain. Represents that a 5- to 6-membered ring may be formed, in which case the alkylene chain may contain one oxygen or sulfur atom and It may be optionally substituted with a so group. ].

R ¹ -X: —C (O) R ^1a and —C (S) R ^1a [wherein R ^1a is (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , E-5, E-6, E-21, E-22 or E-24 to E-26, R ¹⁵ is E-5 to E-8, E-24, E-25, E-27, E-28, -OR ²³ or- N (R ²⁴ ) R ²³ , R ²⁰ represents C ₁ -C ₂ alkyl, and when q4 represents 2, each R ²⁰ may be the same as or different from each other, R ²¹ represents a hydrogen atom, C ₁ -C ₄ alkylcarbonyl or C ₁ -C ₄ alkoxycarbonyl, R ²³ represents a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ cyclo alkyl (C ₁ ~C ₂₎ alkyl, cyano (C ₁ ~C ₂₎ alkyl, C ₃ -C ₄ cycloalkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ alkynyl, -C (O) R ^{31, -C (O) oR 32, -C} (O) SR 32, -C (O) N (R 34) R 33, C 1 ~C 4 alkylsulfonyl, C ₁ -C ₄ haloalkylsulfonyl, phenyl or (Z) It has been replaced by _p1 Represents Eniru, R ²⁴ is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ alkylcarbonyl, C ₁ -C ₄ haloalkylcarbonyl, a C ₁ -C ₄ alkoxycarbonyl or C ₁ -C ₄ alkylsulfonyl Table Alternatively, R ²⁴ may form a C ₄ -C ₅ alkylene chain together with R ²³ to form a 5- to 6-membered ring with the nitrogen atom to which R ²³ and R ²⁴ are bonded. In this case, the alkylene chain may contain one oxygen atom or sulfur atom and may be optionally substituted with an oxo group, and R ³¹ is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl. C ₁ -C ₂ alkoxy (C ₁ -C ₂ ) alkyl, C ₃ -C ₆ cycloalkyl or phenyl, R ³² represents C ₁ -C ₄ alkyl, and R ³³ represents C ₁ -C ₄ alkyl. represents, R ³⁴ represents a hydrogen atom, Z represents a halogen atom, when p1 represents 2, each Z is They may be the same or different from each other, p1 represents an integer of 1 or 2, q4 represents an integer of 0 to 2, q6 and q8 represent 0, and r represents 0 to 2 Represents an integer. ].

R ¹ -XI: —C (O) R ^1a and —C (S) R ^1a [where R ^1a represents —CH (R ^16b ) CH (R ^16a ) —R ¹⁶ , and R ¹⁶ represents —S ( O) _r R ²⁵ or ^{_{-S (O) t (R 25}} ) = represents NR ^25a, R ^16a and R ^16b represents a hydrogen atom or a C ₁ -C ₂ alkyl each independently, R ²⁵ is C ₁ ~ C ₄ alkyl, optionally substituted by R ³⁰ (C ₁ ~C ₄₎ alkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ ^{alkynyl, -C (O) R 31,} -C (O) OR 32 Or -C (O) N (R ³⁴ ) R ³³ , R ^25a represents a hydrogen atom, cyano or C ₁ -C ₂ haloalkylcarbonyl, R ³⁰ represents a halogen atom, cyano or -C (O) N (R ³⁴⁾ represents R ^33, R ³¹ represents a C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or D-24, R ³² represents a C ₁ -C ₄ alkyl, R ³³ is C ₁ -C ₄ R represents alkyl, R ³⁴ represents a hydrogen atom, p 3 represents, r represents an integer of 0 to 2, and t represents an integer of 0 or 1. ].

R ¹ -XII: -C (O) R ^1a [where R ^1a is -C (O) R ⁹ , -C (R ⁹ ) = NOR ¹⁰ , M-7, -C (O) OR ¹⁰ or- C (O) N (R ¹² ) R ¹¹ , R ⁹ represents a hydrogen atom or C ₁ -C ₄ alkyl, R ¹⁰ represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl, R ¹¹ the C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or C ₃ -C ₆ cycloalkyl, R ¹² represents a hydrogen atom, Z is represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl , P5 represents 1 and q2 represents 0. ].

R ¹ -XIII: —C (O) R ^1a and —C (S) R ^1a [where R ^1a is phenyl, phenyl substituted by (Z) _p1 , D-1 to D-4, D-15 represents ~D-17, D-21~D- 24 or D-52~D-59, R ¹⁴ represents a C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl, Z is a halogen atom, cyano, nitro , C ₁ -C ₄ represents alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, a C ₁ -C ₄ alkylthio or C ₁ -C ₄ haloalkylthio, p1 to p4 When Z represents an integer of 2 or more, each Z may be the same as or different from each other, p1 represents an integer of 1 to 5, p2 represents an integer of 0 to 3, p3 and p4 represents an integer of 0 to 2, and t represents 0. ].

R ¹ -XIV: -C (O) OR ^1b , -C (O) SR ^1b , -C (S) OR ^1b , -C (S) SR ^1b and -S (O) ₂ R ^1b [where R ^1b represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, or phenyl. ].

R ¹ -XV: -C (O) N (R ^1d ) R ^1c and -C (S) N (R ^1d ) R ^1c [where R ^1c is a hydrogen atom, C ₁ -C ₆ alkyl, C _1- C ₆ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , -CH ₂ CH ₂ -R ¹⁶ , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl. R ^1d represents a hydrogen atom or C ₁ -C ₆ alkyl, or R ^1d together with R ^1c forms a C ₄ -C ₅ alkylene chain, thereby binding R ^1c and R ^1d to together with the nitrogen atom represent that may form a 5- or 6-membered ring, this time the alkylene chain an oxygen atom, may contain one sulfur atom or a nitrogen atom, and C ₁ -C ₄ alkyl group, - CHO group, C ₁ -C ₄ alkylcarbonyl group, C ₁ -C ₄ alkoxycarbonyl group, C ₁ -C ₄ alkylaminocarbonyl group, C ₁ -C ₄ halo alkylaminocarbonyl group, di (C ₁ -C ₄ alkyl) Aminocal May be optionally substituted by alkylsulfonyl group or an oxo group, R ¹⁵ is cyano, C ₃ -C ₆ ^{cycloalkyl, -OR 23, -N (R 24} ) R 23, -C (O) OR 27, - ^{C (O) N (R 29} ) R 28, -C (S) N (R 29) R 28, tri (C ₁ ~C ₄₎ alkylsilyl, phenyl, phenyl substituted by (Z) _p1, D- 1, D-3, D-21, D-22 or D-52 to D-54, R ¹⁶ represents —S (O) _r R ²⁵ , R ²³ represents C _{1 to} C ₄ alkyl or C ₁ -C ₄ haloalkyl, R ²⁴ represents a C ₁ -C ₄ alkyl, R ²⁵ represents a C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl, R ²⁷ is C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl, R ²⁸ represents a hydrogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl, R ²⁹ represents a hydrogen atom or a C ₁ -C ₄ alkyl, Z is a halogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl, when p1 represents 2, each Z may may be the same with each other or one another May be different, p1 represents an integer of 1 or 2, p2, p3 and p4 is an integer of 0 or 1, r is an integer of 0 to 2, t represents 0. ].

R ¹ -XVI: -C (O) N (R ^1d ) R ^1c and -C (S) N (R ^1d ) R ^1c [where R ^1c is -C (R ⁹ ) = NOR ¹⁰ , C _1- C ₆ alkoxycarbonyl, M-14, M-32 , C 1 ~C 6 alkoxy, C ₁ -C ₆ ^{alkylsulfonyl, -N (R 18) R 17} , phenyl, phenyl or D substituted by (Z) _p1 -52 to D-54, R ^1d represents a hydrogen atom, C _{1 to} C ₆ alkyl or benzyl, R ⁹ represents a hydrogen atom, R ¹⁰ represents C _{1 to} C ₄ alkyl, and R ¹⁷ represents hydrogen. atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ ^{haloalkyl, -C (O) R 26,} -C (O) OR 27, -C (O) N (R 29) R 28, -C (S) N (R ²⁹ ) R ²⁸ , phenyl or phenyl substituted by (Z) _p1 , R ¹⁸ represents a hydrogen atom or C ₁ -C ₄ alkyl, or R ¹⁸ together with R ¹⁷ C ₄ -C by ₅ to form an alkylene chain, it represents that may form a 5- or 6-membered ring together with the nitrogen atom to which R ¹⁷ and R ¹⁸ are bonded, this time the alkylene Oxygen atom may contain one sulfur atom or a nitrogen atom, and optionally substituted by C ₁ -C ₄ alkyl group, -CHO group, C ₁ -C ₄ alkylcarbonyl group or C ₁ -C ₄ alkoxycarbonyl group R ²⁰ represents C ₁ -C ₂ alkyl, and when q 3 and q 5 represent 2, each R ²⁰ may be the same as or different from each other, R ²⁶ the C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or phenyl, R ²⁷ represents a C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl, R ²⁸ is a hydrogen atom, C ₁ -C ₄ alkyl Or C ₁ -C ₄ haloalkyl, R ²⁹ represents a hydrogen atom or C ₁ -C ₄ alkyl, Z is a halogen atom, cyano, nitro, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or C ₁ -C ₄ alkoxy, when p1 and p2 represents 2, each Z is different from even or together the same as each other May have I, p1 represents an integer of 1 or 2, p2 is an integer of 0 to 2, q3 and q5 represents an integer of 0 to 2, t represents 0. ].

R ¹ -XVII: a hydrogen atom.

R ¹ -XVIII: -C (O) R ^1a and -C (S) R ^1a [where R ^1a represents -C (R ^16a ) (R ^16b ) -S (O) _r R ²⁵ or E-7 R ^16a represents a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ alkylthio or C ₁ -C ₂ alkylsulfinyl, R ^16b represents a hydrogen atom, R ²⁵ represents C ₁ -C ₂ alkyl or C ₁ -C ₂ haloalkyl is represented, q 6 represents 0, and r represents an integer of 0-2. ].

R ¹ -XIX: -C (O) R ^1a and -C (S) R ^1a [where R ^1a is -C (R ^16a ) (R ^16b ) -S (O) _r R ²⁵ , -C (R ^16a ) (R ^16b ) -S (O) _t (R ²⁵ ) = NR ^25a , E-7, E-8, E-51 or E-52, R ^16a represents a hydrogen atom, a fluorine atom, C ₁ to C ₂ alkyl, C ₁ -C ₂ alkylthio or C ₁ -C ₂ alkylsulfinyl, R ^16b represents a hydrogen atom or a fluorine atom, R ²⁵ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyanomethyl. R ^25a represents a hydrogen atom or C ₁ -C ₂ haloalkylcarbonyl, q 6 represents 0, r represents an integer of 0 to 2, and t represents an integer of 0 or 1. ].

In the compounds included in the present invention, examples of the range of the substituent represented by R ² include the following groups.

That is, R ² -I: a hydrogen atom.

R _² -II: C ₁ ^{~C 2} alkyl, cyclopropylmethyl, C ₁ -C ₂ alkoxymethyl, cyanomethyl, allyl and propargyl.

R ² -III: C ₁ -C ₄ alkyl, (C ₁ -C ₂ ) alkyl substituted by R ^15a [where R ^15a is cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ represents haloalkoxy, a -N (R ²⁴⁾ R ²³ or C ₁ -C ₂ alkoxycarbonyl, R ²³ represents -C (O) R ³¹ or C ₁ -C ₂ alkoxycarbonyl, R ²⁴ Represents a hydrogen atom, and R ³¹ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyclopropyl. ], C ₃ ~C ₄ alkenyl and C ₃ -C ₄ alkynyl.

R ² -IV: C ₁ ~C ₄ alkyl, C ₃ -C ₄ cycloalkyl (C ₁ ~C ₂₎ alkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ alkynyl and C ₁ -C ₄ alkoxy.

R ² -V: (C ₁ -C ₂ ) alkyl substituted by R ^15a [where R ^15a is C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, C ₁ -C ₂ alkylthio or -N represents ^{(R 24) R 23, R} 23 represents ^{-C (O) R 31, -C} (O) oR 32, -C (O) SR 32 or C ₁ -C ₂ alkylsulfonyl, R ²⁴ is hydrogen Represents an atom, R ³¹ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or C ₃ -C ₄ cycloalkyl, and R ³² represents C ₁ -C ₂ alkyl. ].

R ² -VI: (C ₁ -C ₂ ) alkyl substituted by R ^15a [where R ^15a is cyano, C ₁ -C ₂ alkoxycarbonyl, —C (O) N (R ²⁹ ) R ²⁸ or — C (S) NH ₂ represents, R ²⁸ represents a hydrogen atom, C ₁ -C ₂ alkyl or C ₁ -C ₂ haloalkyl, and R ²⁹ represents a hydrogen atom or C ₁ -C ₂ alkyl. ].

R ² -VII: C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ^15a [where R ^15a is C ₃ -C ₆ cycloalkyl or phenyl To express. ], C ₃ ~C ₆ cycloalkyl, C ₃ -C ₆ alkenyl and C ₃ -C ₆ alkynyl.

R ² -VIII: (C ₁ -C ₂ ) alkyl substituted by R ^15a [where R ^15a is C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ alkylthio, C ₁ -C ₄ alkylsulfinyl, represents C ₁ -C ₄ alkylsulfonyl or ^{-N (R 24) R 23,} R 23 is ^{-C (O) R 31, -C} (O) oR 32, C 1 ~C 4 alkyl represents sulfonyl or C ₁ -C ₄ haloalkylsulfonyl, R ²⁴ represents a hydrogen atom, R ³¹ is C ₁ -C ₄ represents alkyl, C ₁ -C ₄ haloalkyl, a C ₃ -C ₆ cycloalkyl or phenyl, R ³² represents a C ₁ -C ₄ alkyl. ].

R ² -IX: (C ₁ -C ₂ ) alkyl substituted by R ^15a [where R ^15a is cyano, —C (O) OR ²⁷ , —C (O) N (R ²⁹ ) R ²⁸ or — C (S) NH ₂ represents, R ²⁷ represents C ₁ -C ₄ alkyl, R ²⁸ represents a hydrogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl, R ²⁹ represents a hydrogen atom or C 4 It represents a ₁ -C ₄ alkyl. ].

R ² -X: cyano, C ₁ -C ₆ alkylcarbonyl and C ₁ -C ₆ alkoxycarbonyl.

R ² -XI: C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkylthio and -SN (R ^18a ) R ^17a [where R ^17a is C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxycarbonyl ( C ₁ -C ₄ ) alkyl or C ₁ -C ₆ alkoxycarbonyl, R ^18a represents C ₁ -C ₆ alkyl or benzyl. ].

R ² -XII: R ² together with R ¹ forms a C ₄ -C ₆ alkylene chain, thereby forming a 5- to 7-membered ring with the nitrogen atom to which R ¹ and R ² are bonded, The alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and may be optionally substituted with a C ₁ -C ₄ alkyl group, C ₁ -C ₄ alkylidene group, oxo group or thioxo group. .

R _² -XIII: C ₁ ~C ² alkyl and propargyl.

R ² -XIV: C ₁ -C ₂ alkyl, methyl substituted by R ^15a [where R ^15a is cyano, cyclopropyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, C ₁ -C _{2 represents} alkoxycarbonyl, -C (O) N (R ²⁹ ) R ²⁸ or -C (S) NH ₂ , R ²⁸ represents a hydrogen atom or C ₁ -C ₂ alkyl, and R ²⁹ represents a hydrogen atom or methyl. To express. ], Allyl and propargyl.

In the compounds included in the present invention, examples of the preferred range of the substituent represented by R ³ include the following groups.

That is, R ³ -I: trifluoromethyl and chlorodifluoromethyl.

R ³ -II: difluoromethyl, trifluoromethyl, chlorodifluoromethyl, bromodifluoromethyl, 1,1,2,2-tetrafluoroethyl and pentafluoroethyl.

R ³ -III: C ₁ -C ₂ alkyl optionally substituted with two or more optional halogen atoms.

R ³ -IV: C ₁ -C ₂ haloalkyl.

R ³ -V: C ₁ -C ₄ haloalkyl.

R ³ -VI: C ₁ -C ₆ haloalkyl or C ₃ -C ₈ halocycloalkyl.

Of these, more preferable R ³ -I and R ³ -II as the preferred range of the substituent represented by R ^3, furthermore, R ³ -I is particularly preferred.

Each group which shows the range of each substituent in these compounds included in the present invention can be arbitrarily combined, and each represents the range of the present compound. Examples of combinations of ranges for X, Y, R ¹ and R ² include, for example, combinations shown in Table 1 below. However, the combinations in Table 1 are for illustrative purposes, and the present invention is not limited to these.
Table 1 Table 1 (continued)
―――――――――――――――――――――――――――――――――――――――
XYR ¹ R ² XYR ¹ R ²
―――――――――――――――――― ――――――――――――――――――
XI YI R ¹ -IR ² -I XI Y-IV R ¹ -II R ² -II
XI YI R ¹ -IR ² -II XI Y-IV R ¹ -III R ² -I
XI YI R ¹ -IR ² -III XI Y-IV R ¹ -IV R ² -I
XI YI R ¹ -IR ² -IV XI YV R ¹ -IR ² -I
XI YI R ¹ -IR ² -V XI YV R ¹ -IR ² -II
XI YI R ¹ -IR ² -VI XI YV R ¹ -II R ² -I
XI YI R ¹ -IR ² -VII XI YV R ¹ -II R ² -II
XI YI R ¹ -IR ² -VIII XI YV R ¹ -III R ² -I
XI YI R ¹ -IR ² -IX XI YV R ¹ -IV R ² -I
XI YI R ¹ -IR ² -X XI Y-VI R ¹ -IR ² -I
XI YI R ¹ -IR ² -XI XI Y-VI R ¹ -IR ² -II
XI YI − R ² -XII XI Y-VI R ¹ -II R ² -I
XI YI R ¹ -II R ² -I XI Y-VI R ¹ -II R ² -II
XI YI R ¹ -II R ² -II XI Y-VI R ¹ -III R ² -I
XI YI R ¹ -II R ² -III XI Y-VI R ¹ -IV R ² -I
XI YI R ¹ -II R ² -IV X-II YI R ¹ -IR ² -I
XI YI R ¹ -II R ² -V X-II YI R ¹ -IR ² -II
XI YI R ¹ -II R ² -VI X-II YI R ¹ -IR ² -III
XI YI R ¹ -II R ² -VII X-II YI R ¹ -IR ² -IV
XI YI R ¹ -II R ² -VIII X-II YI R ¹ -IR ² -V
XI YI R ¹ -II R ² -IX X-II YI R ¹ -IR ² -VI
XI YI R ¹ -II R ² -X X-II YI R ¹ -II R ² -I
XI YI R ¹ -II R ² -XI X-II YI R ¹ -II R ² -II
XI YI R ¹ -III R ² -I X-II YI R ¹ -II R ² -III
XI YI R ¹ -III R ² -II X-II YI R ¹ -II R ² -IV
XI YI R ¹ -III R ² -III X-II YI R ¹ -II R ² -V
XI YI R ¹ -III R ² -IV X-II YI R ¹ -II R ² -VI
XI YI R ¹ -III R ² -V X-II YI R ¹ -III R ² -I
XI YI R ¹ -III R ² -VI X-II YI R ¹ -III R ² -II
XI YI R ¹ -IV R ² -I X-II YI R ¹ -III R ² -III
XI YI R ¹ -IV R ² -II X-II YI R ¹ -IV R ² -I
XI YI R ¹ -IV R ² -III X-II YI R ¹ -IV R ² -II
XI YI R ¹ -IV R ² -IV X-II YI R ¹ -IV R ² -III
XI YI R ¹ -IV R ² -V X-II YI R ¹ -VR ² -I
XI YI R ¹ -IV R ² -VI X-II YI R ¹ -VR ² -II
XI YI R ¹ -VR ² -I X-II YI R ¹ -VI R ² -I
XI YI R ¹ -VR ² -II X-II YI R ¹ -VI R ² -II
XI YI R ¹ -VR ² -III X-II YI R ¹ -VII R ² -I
XI YI R ¹ -VI R ² -I X-II YI R ¹ -VII R ² -II
XI YI R ¹ -VI R ² -II X-II YI R ¹ -VIII R ² -I
XI YI R ¹ -VI R ² -III X-II YI R ¹ -VIII R ² -II
XI YI R ¹ -VII R ² -I X-II YI R ¹ -IX R ² -I
XI YI R ¹ -VII R ² -II X-II YI R ¹ -XR ² -I
XI YI R ¹ -VII R ² -III X-II YI R ¹ -XI R ² -I
XI YI R ¹ -VIII R ² -I X-II YI R ¹ -XII R ² -I
XI YI R ¹ -VIII R ² -II X-II YI R ¹ -XIII R ² -I
XI YI R ¹ -IX R ² -I X-II YI R ¹ -XIV R ² -I
XI YI R ¹ -IX R ² -II X-II YI R ¹ -XV R ² -I
XI YI R ¹ -XR ² -I X-II YI R ¹ -XVI R ² -I
XI YI R ¹ -XR ² -II X-II Y-II R ¹ -IR ² -I
XI YI R ¹ -XI R ² -I X-II Y-II R ¹ -IR ² -II
XI YI R ¹ -XI R ² -II X-II Y-II R ¹ -IR ² -III
XI YI R ¹ -XII R ² -I X-II Y-II R ¹ -II R ² -I
XI YI R ¹ -XII R ² -II X-II Y-II R ¹ -II R ² -II
XI YI R ¹ -XIII R ² -I X-II Y-II R ¹ -II R ² -III
^{XI YI R 1 -XIII R 2 -II} X-II Y-II R 1 -III R 2 -I
^{XI YI R 1 -XIV R 2 -I} X-II Y-II R 1 -III R 2 -II
XI YI R ¹ -XIV R ² -II X-II Y-II R ¹ -IV R ² -I
XI YI R ¹ -XV R ² -I X-II Y-II R ¹ -IV R ² -II
XI YI R ¹ -XV R ² -II X-II Y-II R ¹ -VR ² -I
XI YI R ¹ -XVI R ² -I X-II Y-II R ¹ -VI R ² -I
XI YI R ¹ -XVI R ² -II X-II Y-II R ¹ -VII R ² -I
XI YI R ¹ -XVII R ² -I X-II Y-II R ¹ -VIII R ² -I
XI YI R ¹ -XVII R ² -II X-II Y-III R ¹ -IR ² -I
XI Y-II R ¹ -IR ² -I X-II Y-III R ¹ -IR ² -II
XI Y-II R ¹ -IR ² -II X-II Y-III R ¹ -II R ² -I
XI Y-II R ¹ -IR ² -III X-II Y-III R ¹ -II R ² -II
XI Y-II R ¹ -IR ² -IV X-II Y-III R ¹ -III R ² -I
XI Y-II R ¹ -IR ² -V X-II Y-III R ¹ -IV R ² -I
XI Y-II R ¹ -IR ² -VI X-III YI R ¹ -IR ² -I
XI Y-II R ¹ -II R ² -I X-III YI R ¹ -IR ² -II
XI Y-II R ¹ -II R ² -II X-III YI R ¹ -IR ² -III
XI Y-II R ¹ -II R ² -III X-III YI R ¹ -II R ² -I
XI Y-II R ¹ -II R ² -IV X-III YI R ¹ -II R ² -II
XI Y-II R ¹ -II R ² -V X-III YI R ¹ -II R ² -III
XI Y-II R ¹ -II R ² -VI X-III YI R ¹ -III R ² -I
XI Y-II R ¹ -III R ² -I X-III YI R ¹ -III R ² -II
XI Y-II R ¹ -III R ² -II X-III YI R ¹ -IV R ² -I
XI Y-II R ¹ -III R ² -III X-III YI R ¹ -IV R ² -II
XI Y-II R ¹ -IV R ² -I X-III YI R ¹ -VR ² -I
XI Y-II R ¹ -IV R ² -II X-III YI R ¹ -VI R ² -I
XI Y-II R ¹ -IV R ² -III X-III YI R ¹ -VII R ² -I
XI Y-II R ¹ -VR ² -I X-III YI R ¹ -VIII R ² -I
XI Y-II R ¹ -VR ² -II X-III Y-II R ¹ -IR ² -I
XI Y-II R ¹ -VI R ² -I X-III Y-II R ¹ -IR ² -II
XI Y-II R ¹ -VI R ² -II X-III Y-II R ¹ -II R ² -I
XI Y-II R ¹ -VII R ² -I X-III Y-II R ¹ -II R ² -II
XI Y-II R ¹ -VII R ² -II X-III Y-II R ¹ -III R ² -I
XI Y-II R ¹ -VIII R ² -I X-III Y-II R ¹ -IV R ² -I
XI Y-II R ¹ -VIII R ² -II X-IV YI R ¹ -IR ² -I
XI Y-II R ¹ -IX R ² -I X-IV YI R ¹ -IR ² -II
XI Y-II R ¹ -XR ² -I X-IV YI R ¹ -II R ² -I
XI Y-II R ¹ -XI R ² -I X-IV YI R ¹ -II R ² -II
XI Y-II R ¹ -XII R ² -I X-IV YI R ¹ -III R ² -I
XI Y-II R ¹ -XIII R ² -I X-IV YI R ¹ -IV R ² -I
XI Y-II R ¹ -XIV R ² -I XV YI R ¹ -IR ² -I
XI Y-II R ¹ -XV R ² -I XV YI R ¹ -IR ² -II
XI Y-II R ¹ -XVI R ² -I XV YI R ¹ -II R ² -I
XI Y-III R ¹ -IR ² -I XV YI R ¹ -II R ² -II
XI Y-III R ¹ -IR ² -II XV YI R ¹ -III R ² -I
XI Y-III R ¹ -IR ² -III XV YI R ¹ -IV R ² -I
XI Y-III R ¹ -II R ² -I X-VI YI R ¹ -IR ² -I
XI Y-III R ¹ -II R ² -II X-VI YI R ¹ -IR ² -II
XI Y-III R ¹ -II R ² -III X-VI YI R ¹ -II R ² -I
XI Y-III R ¹ -III R ² -I X-VI YI R ¹ -II R ² -II
XI Y-III R ¹ -III R ² -II X-VI YI R ¹ -III R ² -I
XI Y-III R ¹ -IV R ² -I X-VI YI R ¹ -IV R ² -I
XI Y-III R ¹ -IV R ² -II X-VII YI R ¹ -XVIII R ² -I
XI Y-III R ¹ -VR ² -I X-VII YI R ¹ -XVIII R ² -XIII
XI Y-III R ¹ -VI R ² -I X-VII YI R ¹ -XVIII R ² -XIV
XI Y-III R ¹ -VII R ² -I X-VII YI R ¹ -XIX R ² -I
XI Y-III R ¹ -VIII R ² -I X-VII YI R ¹ -XIX R ² -XIII
XI Y-IV R ¹ -IR ² -I X-VII Y-II R ¹ -XVIII R ² -I
XI Y-IV R ¹ -IR ² -II X-VII Y-II R ¹ -XVIII R ² -XIII
XI Y-IV R ¹ -II R ² -I X-VII Y-II R ¹ -XIX R ² -I
―――――――――――――――――― ――――――――――――――――――
The compound of the present invention can be produced, for example, by the following method.

  Manufacturing method A

For example, in accordance with the method described in Journal of Heterocyclic Chemistry [J. Heterocyclic Chem.] 2003, 40, 229, etc., general formula (3) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ and m represent the same meaning as described above, J ⁴ represents a chlorine atom, a bromine atom, an iodine atom, a C ₁ -C ₄ alkyl sulfonate group (for example, methanesulfonyloxy). group) or a C ₁ -C ₄ haloalkylsulfonate group (e.g., representing a trifluoromethanesulfonyloxy group) or the like. And 1 to 1.5 equivalents of potassium phthalimide, for example, toluene, dichloromethane, tetrahydrofuran, 1,4-dioxane, acetone, N, N-dimethylformamide, N, N-dimethylacetamide, Dimethyl sulfoxide or the like is used as a solvent, and if necessary, in the presence of 0.1 to 2 equivalents of a base such as sodium carbonate, potassium carbonate or sodium bicarbonate, and 0.1 to 1 equivalents of tetrabutylammonium iodide as a catalyst if necessary. , Tributylhexadecylphosphonium bromide, crown ether (18-Crown-6) and the like, and the reaction is carried out in the temperature range from room temperature to the reflux temperature of the reaction mixture for 0.5 to 24 hours. In the formula, A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ and m have the same meaning as described above. ], For example, toluene, dichloromethane, chloroform, methanol, ethanol, tetrahydrofuran, 1,4-dioxane, water or a mixture of any two or more of them as a solvent, and if necessary, nitrogen In an inert gas atmosphere such as argon, 1 to 4 equivalents of hydrazine monohydrate or hydrazine aqueous solution and 1 room temperature to the reflux temperature of the reaction mixture with respect to 1 equivalent of the compound represented by the general formula (4) by reacting 1 to 24 hours, L is -CH (R ⁴⁾ in the general formula (1) - and the general formula R ¹ and R ² are hydrogen atom (1-1) wherein, a ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ and m have the same meaning as described above. This invention compound represented by this can be obtained.

  Manufacturing method B

For example, according to the method described in The Journal of Organic Chemistry [J. Org. Chem.] 1999, Vol. 64, p. 1015, the general formula (3) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ , m and J ¹ represent the same meaning as described above. And 1 to 1.3 equivalents of hexamethylenetetramine, for example, benzene, toluene, chlorobenzene, dichloromethane, chloroform, 1,2-dichloroethane, methanol, ethanol, etc. General formula (5) obtained by reacting in the temperature range of the reflux temperature of the reaction mixture for 0.5 to 24 hours [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ , m and J ¹ represent the same meaning as described above. A compound represented by the general formula (5) using, for example, methanol, ethanol, acetic acid, propionic acid, water or a mixture of any two or more of them as a solvent. Hydrolysis for 0.5 to 24 hours in the temperature range from room temperature to the reflux temperature of the reaction mixture in the presence of 5 to 100 equivalents of an acid catalyst such as hydrochloric acid, hydrobromic acid, propionic acid, and phosphoric acid. In the general formula (1), L is —CH (R ⁴ ) —, and R ¹ and R ² are hydrogen atoms, wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ and m have the same meaning as described above. This invention compound represented by this can be obtained.

  Manufacturing method C

For example, according to the method described in Journal of Medicinal Chemistry [J. Med. Chem.] 1993, 36, 2558, etc., the general formula (3) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ , m and J ¹ represent the same meaning as described above. And 1 to 3.0 equivalents of sodium azide or lithium azide, if necessary under an inert gas atmosphere such as nitrogen or argon, for example, chloroform, ethanol, acetone, N , N-dimethylformamide, DMPU (N, N′-dimethylpropylene urea), acetonitrile, dimethyl sulfoxide, water or a mixture of any two or more of them as a solvent, and if necessary, 0.005 as a catalyst. Add ~ 0.3 equivalents of tetrabutylammonium hydrogen sulfate, methyltrioctylammonium chloride, lithium iodide, potassium iodide, etc., and react for 0.5 to 48 hours in the temperature range from room temperature to the reflux temperature of the reaction mixture. (Wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ and m have the same meaning as described above) The ], For example, ethanol, tetrahydrofuran, acetonitrile, or a mixture of two or more of them in an arbitrary ratio, etc., as a solvent, 1 to 1 with respect to 1 equivalent of the compound represented by the general formula (6) By reacting with 5 equivalents of triphenylphosphine and 2 to 5 equivalents of water in the temperature range of room temperature to the reflux temperature of the reaction mixture for 2 to 24 hours, L in formula (1) is —CH (R ⁴ ). -Wherein R ¹ and R ² are hydrogen atoms, wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ⁴ , R ⁴ and m are as defined above Means the same. This invention compound represented by this can be obtained.

  In addition, the compound represented by the general formula (6) is converted into, for example, dichloromethane, according to the method described in Journal of Medicinal Chemistry [J. Med. Chem.] 2003, 46, 3116, etc. Using platinum (IV) oxide, palladium-charcoal, etc. as a catalyst in a solvent such as methanol, ethanol, ethyl acetate, or a mixture of two or more of them in any proportion, at room temperature in a hydrogen gas atmosphere of 1 to 4 atm. The compound of the present invention represented by the general formula (1-1) can also be obtained by hydrogenating for 20 minutes to 24 hours.

  Manufacturing method D

General formula (3) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ , m and J ¹ represent the same meaning as described above. And 1 to 40 equivalents of the general formula (7) [wherein R ² represents a hydrogen atom, an alkyl group, a substituted alkyl group, an alkenyl group, an alkynyl group, or the like. Or a salt thereof, if necessary, benzene, toluene, dichloromethane, chloroform, 1,2-dichloroethane, methanol, ethanol, tert-butyl methyl ether, 1,2-dimethoxyethane, tetrahydrofuran, 1, 4-Dioxane, N, N-dimethylformamide, DMPU (N, N′-dimethylpropyleneurea), acetonitrile, water or a mixture of any two or more of them as a solvent, and if necessary, lithium hydroxide , Sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, triethylamine, ethyldiisopropylamine, etc. in the presence of 1 to 10 equivalents of a base, if necessary, 0.1 to 0.5 equivalents of sodium iodide or iodine In the temperature range from 0 ° C. to the reflux temperature of the reaction mixture. By between reaction, L is -CH in formula (1) (R ⁴⁾ - a and the general formula R ¹ is a hydrogen atom (1-2) ^{wherein, A 1, A 2, A} 3 , A ⁴ , G, X, R ³ , R ⁴ and m represent the same meaning as described above, and R ² represents a hydrogen atom, an alkyl group, a substituted alkyl group, an alkenyl group, an alkynyl group or the like. This invention compound represented by this can be obtained.

  The primary amines represented by the general formula (7) used here are known compounds, and some of them are available as commercial products. Others can also be easily synthesized according to the general methods for synthesizing primary amines described in the literature.

  Manufacturing method E

General formula (8) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ and m represent the same meaning as described above, and R ^4a represents a hydrogen atom, an alkyl group or the like. The general Strecker reaction described in the literature, for example, Chemistry Letters [Chem. Lett.] 1987, p. 687, Journal of Medicinal Chemistry [J. Med. Chem.] 1985 , 28, page 1280, etc., by reacting according to the reaction conditions and the like, in general formula (1), L is —C (R ^4a ) (CN) —, and R ¹ and R ² are hydrogen atoms. General formula (1-3) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ and m represent the same meaning as described above, R ^4a represents a hydrogen atom, an alkyl group, etc. Represents. This invention compound represented by this can be obtained.

  Manufacturing method F

General formula (3) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ , m and J ¹ represent the same meaning as described above. ] 1 to 6 equivalents of a cyanating agent such as lithium cyanide, sodium cyanide, potassium cyanide or tetraethylammonium cyanide, for example, toluene, dichloromethane, chloroform, methanol, ethanol, tetrahydrofuran, , 4-dioxane, N, N-dimethylformamide, NMP (N-methyl-2-pyrrolidinone), acetonitrile, dimethyl sulfoxide, water or a mixture of any two or more of them as a solvent, if necessary As a catalyst, 0.05 to 0.25 equivalents of potassium iodide, butyltrimethylammonium chloride, tetrabutylammonium chloride, tetrabutylammonium hydrogen sulfate, crown ether (18-Crown-6) or the like is added, and room temperature to 100 1 in the temperature range of ℃ By reacting 48 hours, the general formula (9) ^{wherein, A 1, A 2, A} 3, A 4, G, X, R 3, R 4 and m are as defined above. The compound represented by this can be obtained.

For example, benzene, methanol, diethyl ether, tetrahydrofuran, or two or more kinds thereof are obtained in an inert gas atmosphere such as nitrogen or argon if necessary, in an equivalent gas of the compound represented by the general formula (9) thus obtained. As a solvent, for example, borane-tetrahydrofuran complex, sodium borohydride-trifluoroacetic acid, sodium borohydride-cobalt (II) chloride, sodium borohydride-nickel (II) chloride, hydrogen 1 to 5 equivalents of a hydrogenating agent such as sodium borohydride-iodine, lithium aluminum hydride, lithium aluminum hydride-aluminum chloride or lithium aluminum hydride-sulfuric acid, and 5 minutes in the temperature range from 0 ° C. to the reflux temperature of the reaction mixture by reacting 24 hours, L in the general formula (1) is -CH (R ⁴⁾ CH ₂ - and are General formula R ¹ and R ² are hydrogen atom (1-4) ^{wherein, A 1, A 2, A} 3, A 4, G, X, R 3, R 4 and m are as defined above To express. This invention compound represented by this can be obtained.

  Manufacturing method G

General formula (9) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ and m represent the same meaning as described above. And a known general formula (10) [wherein R ^4a represents a C _{1 to} C ₆ alkyl group, and J ¹ represents the same meaning as described above. In an inert gas atmosphere such as nitrogen and argon, if necessary, for example, tetrahydrofuran, N, N-dimethylformamide, NMP (N-methyl-2-pyrrolidinone), water or A mixture of any ratio of two or more of them is used as a solvent, for example, in the presence of 1 to 3 equivalents of a base such as sodium hydroxide, potassium hydroxide, potassium tert-butoxide, sodium hydride, etc. 0.005 to 0.01 equivalents of benzyltriethylammonium chloride, benzyltriethylammonium bromide, benzyltributylammonium bromide, crown ether (18-Crown-6), etc. are added as by reacting 24 hours, the general formula (11) ^{wherein, a 1, a 2, a} 3, a 4, G, X, R 3, R 4 and m are as defined above Represents the taste, R ^4a represents C ₁ -C ₆ alkyl group. The compound represented by this can be obtained.

The compound represented by the general formula (11) thus obtained can be obtained by, for example, the method described in The Journal of Organic Chemistry [J. Org. Chem.] 2000, 65, 8152, etc. In accordance with the general formula (12) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ and m are the same as described above] R ^4a represents a C ₁ -C ₆ alkyl group. And then reacting with [I, I-bis (trifluoroacetoxy) iodo] benzene, L in the general formula (1) is -C (R ⁴ ) (R ^4a )- And R ¹ and R ² are hydrogen atoms in general formula (1-5) wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ and m are the same as above R ^4a represents a C ₁ -C ₆ alkyl group. This invention compound represented by this can be obtained.

  Manufacturing method H

General formula (13) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ and m have the same meaning as described above. In the presence of titanium tetra-i-propoxide according to the method described in, for example, The Journal of Organic Chemistry [J. Org. Chem.] 2003, 68, 7133. Under the general formula (1), L is a cyclopropylidene group and R ¹ and R ² are hydrogen atoms by reacting with ethyl magnesium bromide and then reacting with boron trifluoride diethyl ether complex. Formula (1-6) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ and m have the same meaning as described above. This invention compound represented by this can be obtained.

  Some of the compounds represented by the general formula (13) used here are known compounds described in International Patent Application Publication (WO 2005/085216), and others are the methods described in the literature. Can be synthesized in the same manner as known compounds.

  Manufacturing method I

General formula (1-7) wherein R ¹ is a hydrogen atom in general formula (1) [where A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ² , R ³ and m are Represents the same meaning as above. In the formula, R ^1a represents the same meaning as described above, J ² represents a chlorine atom, a bromine atom, C ₁ -C. ₄ alkylcarbonyloxy group (e.g., pivaloyloxy group), C ₁ -C ₄ alkoxycarbonyloxy group (e.g., isobutyl oxycarbonitride noroxycodone group) or azolyl group (e.g., imidazol-1-yl group). Or a general formula (15) [wherein R ^1a represents the same meaning as described above.] ], For example, dichloromethane, chloroform, diethyl ether, tert-butyl methyl ether, tetrahydrofuran, 1,4-dioxane, ethyl acetate, acetonitrile, etc. as a solvent, and if necessary, carbonic acid In the presence of 1-2 equivalents of a base such as sodium, potassium carbonate, triethylamine, pyridine or 4- (dimethylamino) pyridine, the reaction is carried out in the temperature range from 0 ° C. to the reflux temperature of the reaction mixture for 10 minutes to 24 hours. General formula (1-8) in which R ¹ is -C (O) R ^1a in formula (1) [where A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ^1a , R ² , R ³ and m have the same meaning as described above. This invention compound represented by this can be obtained.

  Manufacturing method J

General formula (1-7) wherein R ¹ is a hydrogen atom in general formula (1) [where A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ² , R ³ and m are Represents the same meaning as above. In the formula, R ^1a represents the same meaning as described above. 1 equivalent of the compound of the present invention represented by the general formula (16) ], For example, dichloromethane, chloroform, diethyl ether, tert-butyl methyl ether, tetrahydrofuran, 1,4-dioxane and the like, if necessary, sodium carbonate, potassium carbonate, triethylamine, 1 to 4 equivalents of WSC (1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride), CDI (carbonyldiimidazole) in the presence of 1 to 4 equivalents of a base such as pyridine or 4- (dimethylamino) pyridine In the general formula (1), R ¹ is —C (O) R ^1a by reacting in a temperature range of 0 ° C. to the reflux temperature of the reaction mixture using a condensing agent such as (1-8) [wherein, A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ^1a , R ² , R ³ and m have the same meaning as described above. This invention compound represented by this can be obtained.

  Production method K

General formula (1-7) wherein R ¹ is a hydrogen atom in general formula (1) [where A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ² , R ³ and m are Represents the same meaning as above. The compound of the present invention represented by general formula (17) [wherein R ^1b represents the same meaning as described above, J ³ represents a halogen atom such as a chlorine atom or a bromine atom, and W ¹ and W ² Each independently represents an oxygen atom or a sulfur atom. Or a known general formula (18) [wherein R ^1b represents the same meaning as described above, and W ¹ and W ² each independently represents an oxygen atom or a sulfur atom. And a compound represented by the general formula (1) in which R ¹ is —C (W ¹ ) —W ² —R ^1b in the general formula ( ¹ ). 1-9) [wherein, A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ^1b , R ² , R ³ and m represent the same meaning as described above, and W ¹ and W ² are Each independently represents an oxygen atom or a sulfur atom. This invention compound represented by this can be obtained.

  Manufacturing method L

General formula (1-7) wherein R ¹ is a hydrogen atom in general formula (1) [where A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ² , R ³ and m are Represents the same meaning as above. The compound of the present invention represented by the general formula (19) represented by 1 equivalent to 1 to 1.2 equivalents [wherein R ^1c and W ¹ represent the same meaning as described above. For example, dichloromethane, 1,2-dichloroethane, methanol, ethanol, tetrahydrofuran, 1,4-dioxane, N, N-dimethylformamide, water, etc. In the presence of 1 to 4 equivalents of a base such as sodium, potassium carbonate, triethylamine, pyridine or 4- (dimethylamino) pyridine, the reaction is carried out in the temperature range from 0 ° C. to the reflux temperature of the reaction mixture for 2 minutes to 24 hours. General formula (1-10) wherein R ¹ is -C (W ¹ ) NHR ^1c in formula ( ¹ ) [where A ¹ , A ² , A ³ , A ⁴ , G, L, W ¹ , X, R ^1c , R ² , R ³ and m have the same meaning as described above. This invention compound represented by this can be obtained.

  Manufacturing method M

General formula (1-7) wherein R ¹ is a hydrogen atom in general formula (1) [wherein A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ² , R ⁴ and m are Represents the same meaning as above. The compound of the present invention represented by the general formula (20) [wherein R ^1c , R ^1d , W ¹ and J ³ represent the same meaning as described above. And a compound represented by the general formula (1) in which R ¹ is —C (W ¹ ) N (R ^1d ) R ^1c (1-11) [wherein A ¹ , A ² , A ³ , A ⁴ , G, L, W ¹ , X, R ^1c , R ^1d , R ² , R ³ and m represent the same meaning as described above. . This invention compound represented by this can be obtained.

  Manufacturing method N

General formula (1-7) wherein R ¹ is a hydrogen atom in general formula (1) [where A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ² , R ³ and m are Represents the same meaning as above. The compound of the present invention represented by general formula (21) [wherein R ^1b and J ³ represent the same meaning as described above. Or a known general formula (22) [wherein R ^1b represents the same meaning as described above. And the compound represented by the general formula (1-12) in which R ¹ is —S (O) ₂ R ^1b in the general formula (1) [Wherein, A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ^1b , R ² , R ³ and m have the same meaning as described above. This invention compound represented by this can be obtained.

  Manufacturing method O

General formula (1-7) wherein R ¹ is a hydrogen atom in general formula (1) [where A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ² , R ³ and m are Represents the same meaning as above. The compound of the present invention represented by general formula (23) [wherein R ^1c , R ^1d and J ³ represent the same meaning as described above. And a compound represented by the general formula (1) in which R ¹ is —S (O) ₂ N (R ^1d ) R ^1c (1-13) [wherein, A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ^1c , R ^1d , R ² , R ³ and m have the same meaning as described above. This invention compound represented by this can be obtained.

  Production method P

General formula (24) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ and m have the same meaning as described above. 1 equivalent of the compound represented by the general formula (25) [wherein R ¹ and R ² represent the same meaning as described above. ], For example, hexane, dichloromethane, methanol, ethanol or the like is used as a solvent, and if necessary, 0.01 to 0.1 equivalent of acetic acid or hydrochloric acid or the like is added as a catalyst, or 1 . General Formula (26) obtained by reacting in the presence of 5-2 equivalents of triethylamine in the temperature range of room temperature to the reflux temperature of the reaction mixture for 20 minutes to 24 hours, wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ¹ , R ² , R ³ , R ⁴ and m have the same meaning as described above. In an inert gas atmosphere such as nitrogen or argon, if necessary, for example, dichloromethane, methanol, tetrahydrofuran, acetic acid, trifluoroacetic acid, acetonitrile, water, or an arbitrary ratio of two or more thereof As a solvent, 0.01 to 0.1 equivalent of acetic acid, trifluoroacetic acid or hydrochloric acid is added as necessary, and 1 to 20 equivalents of borane-tetrahydrofuran complex, borane-pyridine complex, hydrogen In the general formula (1), L is —CH (R ⁴ ) by reacting with a reducing agent such as sodium borohydride, sodium cyanoborohydride, or triethylsilane at a temperature range of −20 ° C. to 60 ° C. for 10 minutes to 18 hours. ) NH-general formula (1-14) wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ¹ , R ² , R ³ , R ⁴ and m are as defined above Represents. This invention compound represented by this can be obtained.

  Some of the compounds represented by the general formula (25) used here are known compounds, and some of them are commercially available. In addition, other compounds can be easily synthesized according to the synthesis methods of general known compounds described in the literature.

  Manufacturing method Q

General formula (1-15) in which R ² is a hydrogen atom in general formula (1) [where A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ¹ , R ³ and m are Represents the same meaning as above. 1 equivalent and 1-10 equivalents of the general formula (27) [wherein R ² represents the same meaning as described above except for a hydrogen atom, and J ⁴ represents a chlorine atom, a bromine atom, an iodine atom. , C ₁ -C ₄ alkylcarbonyloxy group (e.g., pivaloyloxy group), C ₁ -C ₄ alkyl sulfonate group (e.g., methanesulfonyloxy group), C ₁ -C ₄ haloalkylsulfonate group (e.g., trifluoromethanesulfonyloxy group ), An arylsulfonate group (for example, benzenesulfonyloxy group, p-toluenesulfonyloxy group) or an azolyl group (for example, imidazol-1-yl group). ], For example, tert-butyl methyl ether, tetrahydrofuran, 1,4-dioxane, N, N-dimethylformamide, acetonitrile or the like as a solvent, and if necessary, sodium hydride, sodium hydroxide, water By reacting in the temperature range of 0 to 90 ° C. for 10 minutes to 24 hours in the presence of 1 to 3 equivalents of a base such as potassium oxide, potassium tert-butoxide, sodium carbonate, potassium carbonate, triethylamine or pyridine, the general formula ( 1) [wherein A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ¹ , R ³ and m have the same meaning as described above, and R ² has the same meaning as described above except for a hydrogen atom. Represents. This invention compound represented by this can be obtained.

  Some of the compounds represented by the general formula (27) used here are known compounds, and some of them are commercially available. Other than the above, general synthesis methods described in the literature, for example, Chemistry Letters [Chem. Lett.] 1976, 373 pages, Journal of the American Chemical Society [J. Am. Chem. Soc.] 1964, 86, 4383, The Journal of Organic Chemistry [J. Org. Chem.] 1976, 41, 4028 and 1978, 43, 3244, Organic Synthesis [Org. Synth.] 1988, Collective Volume 6, p. 101, Tetrahedron Lett. 1972, p. 4339, British Patent Gazette (GB 2,161,802), European Patent Gazette (EP 0,051,273) ) And the like.

  Manufacturing method R

In general formula (1), R ¹ is -C (O) R ^1a (wherein A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ^1a , R ² , R ³ and m have the same meaning as described above. 1 equivalent and 1 to 10 equivalents of diphosphorus pentasulfide, diphosphorus pentasulfide-HMDO (hexamethyldisiloxane), Lawesson's Reagent; 2,4-bis (4-methoxyphenyl) ) -1,3,4,4-dithiadiphosphetane = 2,4-disulfide) and the like, if necessary, benzene, toluene, chlorobenzene, dichloromethane, chloroform, 1,2-dichloroethane, tert- Use butyl methyl ether, 1,2-dimethoxyethane, tetrahydrofuran, 1,4-dioxane or HMPA (hexamethylphosphoric triamide) as a solvent, and if necessary, sodium carbonate, potassium carbonate, sodium bicarbonate, triethylamine or pyridine In the presence of 1 to 4 equivalents of a base such as room temperature to the reflux temperature of the reaction mixture for 10 minutes to 50 hours, Alternatively, by using a base such as pyridine as a solvent and reacting in a temperature range of 80 ° C. to the reflux temperature of the reaction mixture for 1 to 3 hours, R ¹ in the general formula (1) is —C (S) R ^1a Formula (1-16) [wherein A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ^1a , R ² , R ³ and m have the same meaning as described above. This invention compound represented by this can be obtained.

  Manufacturing method S

Formula (28) [wherein A ¹ , A ² , A ³ , A ⁴ , L, R ¹ and R ² represent the same meaning as described above. And a halogenating agent 1 such as N-chlorosuccinimide, N-bromosuccinimide, aqueous sodium hypochlorite, hypochlorous acid-tert-butyl ester, chlorine gas, bromine and the like. ~ 2 equivalents using, for example, dichloromethane, chloroform, 1,2-dichloroethane, 1,2-dimethoxyethane, tetrahydrofuran, 1,4-dioxane, N, N-dimethylformamide, N, N-dimethylacetamide and the like as a solvent The reaction is carried out at a temperature ranging from 0 ° C. to the reflux temperature of the reaction mixture for 10 minutes to 2 hours to give a compound represented by the general formula (29) [wherein A ¹ , A ² , A ³ , A ⁴ , L, R ^{1 2} represents the same meaning as described above, and J ³ represents a halogen atom such as a chlorine atom or a bromine atom. ] Can be obtained.

1 equivalent of the compound represented by the general formula (29) thus obtained and 1 to 2 equivalents of the general formula (30) [wherein G, X, R ³ and m represent the same meaning as described above. ], For example, dichloromethane, chloroform, 1,2-dichloroethane, 1,2-dimethoxyethane, tetrahydrofuran, 1,4-dioxane, N, N-dimethylformamide, N, N-dimethylacetamide and the like. Used as a solvent, if necessary, in the presence of 1 to 2 equivalents of a base such as sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate or triethylamine, at a temperature range of 0 ° C. to the reflux temperature of the reaction mixture for 10 minutes to 24 hours. By reacting, general formula (1) [wherein A ¹ , A ² , A ³ , A ⁴ , G, L, X, R ¹ , R ² , R ³ and m have the same meaning as described above. This invention compound represented by this can be obtained.

  The compound represented by the general formula (30) used here is a known compound described in International Patent Application Publication (WO 2005/085216) and the like.

  In production method A to production method S, the reaction mixture after completion of the reaction is directly concentrated or dissolved in an organic solvent, concentrated after washing with water, or poured into ice water, followed by usual post-treatment such as extraction after organic solvent extraction. Of the present invention can be obtained. Moreover, when the necessity for purification arises, it can be separated and purified by any purification method such as recrystallization, column chromatograph, thin layer chromatograph, liquid chromatographic fractionation and the like.

  Compound represented by general formula (3) used in production method A to production method D and production method F, compound represented by general formula (8) used in production method E, and general formula used in production method P The compounds represented by (24) can be synthesized, for example, as shown in Reaction Schemes 1 to 4.

  Reaction formula 1

General formula (31) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ and m represent the same meaning as described above, J ⁵ represents a bromine atom, an iodine atom or C ₁ -C _{4 represents a} haloalkylsulfonate group (for example, trifluoromethanesulfonyloxy group) and the like. ] In a known method described in the literature, for example, Bulletin of the Chemical Society of Japan [Bull. Chem. Soc. Jpn.] 1994, Vol. 67, page 2329, etc. According to the method, by performing a CO insertion reaction using a transition metal catalyst such as palladium in the presence of a hydride source such as formic acid, the general formula (8-1) wherein R ^4a is a hydrogen atom in the general formula (8) A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ and m have the same meaning as described above. ] Can be synthesized.

The compound represented by the general formula (8-1) thus obtained was converted to a known method described in the literature, for example, The Journal of Organic Chemistry [J. Org. Chem.] 1999, Vol. 64. 2873, 2000, 65, 4618, etc., in accordance with the general formula (32) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ and m are R ⁴ represents the same meaning as described above except for a hydrogen atom. In accordance with the method described in, for example, Journal of the American Chemical Society [J. Am. Chem. Soc.] 1986, 108, 6819, etc. By halogenation or by sulfonyl esterification according to the method described in, for example, The Journal of Organic Chemistry [J. Org. Chem.] 2004, Vol. (3) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , m and J ¹ represent the same meaning as described above, and R ⁴ has the same meaning as described above except for a hydrogen atom. To express. ] Can be synthesized.

In addition, the compound represented by the general formula (8-1) is described in known methods described in the literature, for example, Journal of Medicinal Chemistry [J. Med. Chem.] 2007, 50, 2424. According to the method, R ⁴ is a hydrogen atom in general formula (32) in general formula (32-1) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ and m are Means the same. And then halogenated, or according to the method described in, for example, Bioorganic & Med. Chem. 1999, Vol. 7, p. 2647 By sulfonyl esterification, general formula (3-1) wherein R ⁴ is a hydrogen atom in general formula (3) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , m and J ¹ represent the same meaning as described above. ] Can be synthesized.

  Reaction formula 2

Formula (31) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , m and J ⁵ represent the same meaning as described above. ] According to a known method described in the literature, for example, according to the method described in The Journal of Organic Chemistry [J. Org. Chem.] 2001, 66, 4340, etc. (Wherein J ⁶ represents a hydrogen atom or a tri-n-butylstannyl group, R represents a C _{1 to} C ₈ alkyl group, a 2-hydroxyethyl group, a 2-vinyloxy group) Represents an ethyl group and the like. In general formula (24-1), R ⁴ is a methyl group in the general formula (24), wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ and m have the same meaning as described above. ] Can be synthesized.

The compound represented by the general formula (24-1) thus obtained is converted to a known method described in the literature, for example, Chemical and Pharmaceutical Bulletin [Chem. Pharm. Bull.] 2001, vol. 49. In the general formula (32), R ⁴ is a methyl group according to the method described on page 799, etc. [wherein A ¹ , A ² , A ³ , A ⁴ , G, X , R ³ and m have the same meaning as described above. And then halogenated, or according to the method described in, for example, Journal of Medicinal Chemistry [J. Med. Chem.] 2001, 44, 3343, etc. By sulfonyl esterification, in the general formula (3), R ⁴ is a methyl group (3-2) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , m and J ¹ represent the same meaning as described above. ] Can be synthesized.

  Reaction formula 3

Formula (31) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ and m represent the same meaning as described above, and J ⁵ represents a bromine atom or an iodine atom. The compound represented by the general formula (34) according to a known method described in the literature, for example, the method described in Journal of Medicinal Chemistry [J. Med. Chem.] 2004, 47, 2405, etc. [Wherein R ^4a represents the same meaning as described above, and J ⁷ represents a C ₁ -C ₄ alkoxy group, a di (C ₁ -C ₄ alkyl) amino group, a piperidino group, a morpholino group, a methoxy (methyl) amino group. Etc. Or a compound represented by the general formula (35): wherein R ⁴ and J ⁷ represent the same meaning as described above. And a compound represented by the general formula (8): wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ^4a , R ³ and m have the same meaning as described above. To express. Or a compound represented by the general formula (24): wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ and m have the same meaning as described above. ] Can be synthesized respectively.

  Some of the compounds represented by the general formula (34) and the compounds represented by the general formula (35) used here are known compounds, and some of them are commercially available. In addition, other compounds can be easily synthesized according to the synthesis methods of general known compounds described in the literature.

By reacting the compound represented by the general formula (24) thus obtained in the same manner as in the reaction formula 2, the general formula (3) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ , m and J ¹ represent the same meaning as described above. ] Can be synthesized.

  Some of the compounds represented by the general formula (31) used in the reaction formulas 1 to 3 are known compounds described in International Patent Application Publication (WO 2005/085216), and others Can be synthesized in the same manner as known compounds according to the methods described in the literature.

  Reaction formula 4

General formula (36) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ and m represent the same meaning as described above. N-chlorosuccinic acid according to a known method described in the literature, for example, the method described in Journal of Medicinal Chemistry [J. Med. Chem.] 1991, 34, 2209, etc. By halogenating with imide, N-bromosuccinimide, etc., general formula (3) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ and m are The same meaning as described above is represented, and J ¹ represents a chlorine atom, a bromine atom or the like. ] Can be synthesized.

  The compound represented by the general formula (28) used in production method S can be synthesized, for example, as follows.

  Reaction formula 5

That is, in the general formula (37) [wherein A ¹ , A ² , A ³ , A ⁴ , L, R ¹ and R ² represent the same meaning as described above. ] In accordance with a known method described in the literature, for example, according to the method described in Journal of Medicinal Chemistry [J. Med. Chem.] 2001, 44, 2308, etc. By reacting with a salt, general formula (27) [wherein A ¹ , A ² , A ³ , A ⁴ , L, R ¹ and R ² represent the same meaning as described above. ] Can be easily synthesized.

  The compound represented by the general formula (36) can be synthesized, for example, as follows.

  Reaction formula 6

That is, general formula (38) [wherein A ¹ , A ² , A ³ , A ⁴ and R ⁴ represent the same meaning as described above. The compound represented by general formula (36) [wherein A ¹ , A ² , A ³ , A ⁴ , G, X, R ³ , R ⁴ and m Represents the same meaning as described above. ] Can be synthesized.

  Some of the compounds represented by the general formula (38) used here are known compounds, and some of them are available as commercial products. In addition, other compounds can be easily synthesized according to the synthesis methods of general known compounds described in the literature.

  The compound represented by the general formula (37) can be synthesized, for example, as follows.

  Reaction formula 7

That is, the general formula (40) [wherein A ¹ , A ² , A ³ , A ⁴ , L, R ¹ , R ² and J ⁵ represent the same meaning as described above. The compound represented by the general formula (37) [wherein A ¹ , A ² , A ³ , A ⁴ , L, R ¹ and R ² are Means the same. The compound represented by this can be obtained.

  The compound represented by the general formula (40) can be synthesized, for example, as shown in Reaction Formula 8 to Reaction Formula 11.

  Reaction formula 8

Known general formula (41) [wherein A ¹ , A ² , A ³ , A ⁴ , R ⁴ and J ⁵ represent the same meaning as described above. Or a known general formula (44) [wherein A ¹ , A ² , A ³ , A ⁴ , R ⁴ and J ^5] Represents the same meaning as described above. The compound represented by the general formula (43) obtained by reacting the compound represented by formula 4 in the same manner as in the reaction scheme 4, wherein A ¹ , A ² , A ³ , A ⁴ , R ⁴ , J ¹ and J ⁵ are Means the same. ] Is reacted in the same manner as in Production Method A to Production Method D, Production Method I to Production Method O, or Production Method Q, whereby L in formula (40) is -CH (R ⁴ )- General formula (40-1) to general formula (40-4), wherein A ¹ , A ² , A ³ , A ⁴ , R ¹ , R ² , R ⁴ and J ⁵ have the same meaning as described above. To express. ] Can be synthesized.

  Reaction formula 9

Known general formula (45) [wherein A ¹ , A ² , A ³ , A ⁴ , R ^4a and J ⁵ represent the same meaning as described above. In the general formula (40), L is —C (R ^4a ) (CN) — by reacting the compound represented by formula (40) in the same manner as in Production Method E, Production Method I to Production Method O, or Production Method Q. A general formula (40-5) to general formula (40-7) [wherein A ¹ , A ² , A ³ , A ⁴ , R ¹ , R ² , R ^4a and J ⁵ represent the same meaning as described above. . ] Can be synthesized.

  Reaction formula 10

General formula (43) [wherein A ¹ , A ² , A ³ , A ⁴ , R ⁴ , J ¹ and J ⁵ represent the same meaning as described above. In the general formula (40), L is —C (R ⁴ ) CH ₂ — by reacting the compound represented by formula (I) in the same manner as in Production Method F, Production Method I to Production Method O, or Production Method Q. General formula (40-8) to general formula (40-10) [wherein A ¹ , A ² , A ³ , A ⁴ , R ¹ , R ² , R ⁴ and J ⁵ represent the same meaning as described above. ] Can be synthesized.

Further, in the general formula (46) [wherein A ¹ , A ² , A ³ , A ⁴ , R ⁴ and J ⁵ represent the same meaning as described above. In the general formula (40), L is —C (R ⁴ ) (R ^4a ) — by reacting the compound represented by formula (I) in the same manner as in Production Method G, Production Method I to Production Method O, or Production Method Q. General formula (40-11) to general formula (40-13) wherein A ¹ , A ² , A ³ , A ⁴ , R ¹ , R ² , R ⁴ , R ^4a and J ⁵ are Represents the same meaning. ] Can be synthesized.

  Reaction formula 11

Known general formula (49) [wherein A ¹ , A ² , A ³ , A ⁴ and J ⁵ represent the same meaning as described above. ] Is reacted in the same manner as in Production Method H, Production Method I to Production Method O, or Production Method Q, so that in formula (40), L is a cyclopropylidene group (40- 14) to general formula (40-16) [wherein A ¹ , A ² , A ³ , A ⁴ , R ¹ , R ² and J ⁵ represent the same meaning as described above. ] Can be synthesized.

  In each of these reactions, after the completion of the reaction, each of the production intermediates that are the raw material compounds of Production Method A to Production Method G, Production Method P, and Production Method S can be obtained by performing an ordinary post-treatment.

  In addition, each production intermediate produced by these methods can be used as it is in the subsequent step without isolation and purification.

  Specific examples of the active compound included in the present invention include compounds shown in Tables 2 and 3. Specific examples of the compound that can be used as a novel production intermediate for producing the active compound included in the present invention include compounds shown in Table 4. However, the compounds in Tables 2 to 4 are for illustrative purposes, and the present invention is not limited thereto.

  In the table, “Et” represents an ethyl group. Similarly, n-Pr and Pr-n are normal propyl groups, i-Pr and Pr-i are isopropyl groups, and c-Pr and Pr-c are Cyclopropyl group, n-Bu and Bu-n are normal butyl groups, i-Bu and Bu-i are isobutyl groups, s-Bu and Bu-s are secondary butyl groups, c-Bu and Bu-c Is a cyclobutyl group, t-Bu and Bu-t are tertiary butyl groups, n-Pen and Pen-n are normal pentyl groups, c-Pen and Pen-c are cyclopentyl groups, n-Hex and Hex- n represents a normal hexyl group, c-Hex and Hex-c represent a cyclohexyl group, Ph represents a phenyl group, 1-Naph represents a 1-naphthyl group, and 2-Naph represents a 2-naphthyl group.

  In addition, the aromatic heterocycles represented by D-1a to D-63a in the table each represent the following structure,

For example, the notation [C (O) (D-53b) Cl] represents a 2-chloronicotinoyl group, and the notation [C (O) CH ₂ (D-52a)] represents a 2-pyridylacetyl group. Represent,
The aliphatic heterocycles represented by E-5a to E-35a in the table each represent the following structure,

For example, the notation [C (O) (E-6a)] represents a 3-tetrahydrofurylcarbonyl group, and the notation [C (O) (E-21a) C (O) OCH ₃ ] represents N-methoxy. Represents a carbonyl-2-thiazolidinecarbonyl group,
The partially saturated heterocyclic rings represented by M-11a to M-36a in the table each represent the following structure.

  Further, T-1 to T-40 in the table each represent the following structure.

In Table 2, the numbers representing the substitution positions of the substituent (X) _m correspond to the positions of the numbers described in the following structural formulas.

―――――――――――――――――――――――――――――――――――――――
(X)_m                   R^Three           R^Four         R²         R¹
―――――――――――――――――――――――――――――――――――――――
3-F CF_Three          H H C (O) Pr-n
3-F CF_Three          H H C (O) Pr-c
3-F CF_Three          H H C (O) CH₂Pr-c
3-F CF_Three          H H C (O) CH₂CF_Three
3-F CF_Three          H H C (O) (E-6a)
4-F CF_Three          H H C (O) Pr-n
3-Cl CF_Three          H H C (O) Et
3-Cl CF_Three          H H C (O) Pr-n
3-Cl CF_Three          H H C (O) Pr-c
3-Cl CF_Three          H H C (O) CH₂Pr-c
3-Cl CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Cl CF_Three          H H C (O) CH₂CF_Three
3-Cl CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Cl CF_Three          H H C (O) (E-6a)
3-Cl CF_Three          CH_Three        H C (O) (E-6a)
3-Cl CF_Three          CH_Three        H C (O) NHPr-c
3-Cl CF₂Cl H H C (O) Pr-c
4-Cl CF_Three          H H C (O) CH₂Pr-c
3-Br CHF₂         H H C (O) CH₂CF_Three
3-Br CF_Three          H H C (O) Et
3-Br CF_Three          H H C (O) Pr-n
3-Br CF_Three          H H C (O) Pr-i
3-Br CF_Three          H H C (O) Pr-c
3-Br CF_Three          CH_Three        H C (O) Pr-c
3-Br CF_Three          H H C (O) Bu-i
3-Br CF_Three          H H C (O) CH₂Pr-c
3-Br CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Br CF_Three          H H C (O) CH₂CF_Three
3-Br CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Br CF_Three          H H C (O) (E-6a)
3-Br CF_Three          CH_Three        H C (O) (E-6a)
3-Br CF_Three          H H C (O) NHPr-c
3-Br CF_Three          CH_Three        H C (O) NHPr-c
3-Br CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Br CF₂Cl H H C (O) Pr-n
3-Br CF₂Cl H H C (O) Pr-c
3-Br CF₂Cl H H C (O) CH₂Pr-c
3-Br CF₂Cl H H C (O) CH₂CF_Three
3-Br CF₂Cl H H C (O) (E-6a)
4-Br CF_Three          H H C (O) (E-6a)
3-I CHF₂         H H C (O) Pr-n
3-I CHF₂         H H C (O) Pr-c
3-I CHF₂         H H C (O) CH₂Pr-c
3-I CHF₂         H H C (O) CH₂CF_Three
3-I CHF₂         H H C (O) (E-6a)
3-I CF_Three          H H C (O) Et
3-I CF_Three          H Et C (O) Et
3-I CF_Three          H CH₂C≡CH C (O) Et
3-I CF_Three          CH_Three        H C (O) Et
3-I CF_Three          H H C (O) Pr-n
3-I CF_Three          H Et C (O) Pr-n
3-I CF_Three          CH_Three        H C (O) Pr-n
3-I CF_Three          H H C (O) Pr-i
3-I CF_Three          CH_Three        H C (O) Pr-i
3-I CF_Three          H H C (O) Pr-c
3-I CF_Three          H Et C (O) Pr-c
3-I CF_Three          H CH₂Pr-c C (O) Pr-c
3-I CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-I CF_Three          H CH₂C≡CH C (O) Pr-c
3-I CF_Three          CH_Three        H C (O) Pr-c
3-I CF_Three          CH_Three        Et C (O) Pr-c
3-I CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-I CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-I CF_Three          H H C (O) Bu-i
3-I CF_Three          H H C (O) CH₂Pr-c
3-I CF_Three          H Et C (O) CH₂Pr-c
3-I CF_Three          CH_Three        H C (O) CH₂Pr-c
3-I CF_Three          H H C (O) CH₂CF_Three
3-I CF_Three          CH_Three        H C (O) CH₂CF_Three
3-I CF_Three          H H C (O) (E-6a)
3-I CF_Three          CH_Three        H C (O) (E-6a)
3-I CF_Three          H H C (O) NHEt
3-I CF_Three          H H C (O) NHPr-c
3-I CF_Three          CH_Three        H C (O) NHPr-c
3-I CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-I CF₂Cl H H C (O) Et
3-I CF₂Cl H H C (O) Pr-n
3-I CF₂Cl H H C (O) Pr-c
3-I CF₂Cl H H C (O) CH₂Pr-c
3-I CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-I CF₂Cl H H C (O) CH₂CF_Three
3-I CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-I CF₂Cl H H C (O) (E-6a)
3-I CF₂Cl CH_Three        H C (O) (E-6a)
3-I CF₂Cl CH_Three        H C (O) NHPr-c
3-I CF₂Br H H C (O) Pr-n
3-I CF₂CHF₂      H H C (O) Pr-c
3-I CF₂CF_Three       H H C (O) CH₂Pr-c
4-I CF_Three          H H C (O) CH₂CF_Three
3-CH_Three                  CF_Three          H H C (O) (E-6a)
3-i-Pr CF_Three          H H C (O) Pr-n
3-CF_Three                  CHF₂         H H C (O) Pr-n
3-CF_Three                  CHF₂         H H C (O) Pr-c
3-CF_Three                  CHF₂         H H C (O) CH₂Pr-c
3-CF_Three                  CHF₂         H H C (O) CH₂CF_Three
3-CF_Three                  CHF₂         H H C (O) (E-6a)
3-CF_Three                  CF_Three          H H C (O) Et
3-CF_Three                  CF_Three          H Et C (O) Et
3-CF_Three                  CF_Three          H CH₂C≡CH C (O) Et
3-CF_Three                  CF_Three          CH_Three        H C (O) Et
3-CF_Three                  CF_Three          H H C (O) Pr-n
3-CF_Three                  CF_Three          H Et C (O) Pr-n
3-CF_Three                  CF_Three          CH_Three        H C (O) Pr-n
3-CF_Three                  CF_Three          H H C (O) Pr-i
3-CF_Three                  CF_Three          CH_Three        H C (O) Pr-i
3-CF_Three                  CF_Three          H H C (O) Pr-c
3-CF_Three                  CF_Three          H Et C (O) Pr-c
3-CF_Three                  CF_Three          H CH₂Pr-c C (O) Pr-c
3-CF_Three                  CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-CF_Three                  CF_Three          H CH₂C≡CH C (O) Pr-c
3-CF_Three                  CF_Three          CH_Three        H C (O) Pr-c
3-CF_Three                  CF_Three          CH_Three        Et C (O) Pr-c
3-CF_Three                  CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-CF_Three                  CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-CF_Three                  CF_Three          H H C (O) Bu-i
3-CF_Three                  CF_Three          H H C (O) CH₂Pr-c
3-CF_Three                  CF_Three          H Et C (O) CH₂Pr-c
3-CF_Three                  CF_Three          CH_Three        H C (O) CH₂Pr-c
3-CF_Three                  CF_Three          H H C (O) CH₂CF_Three
3-CF_Three                  CF_Three          CH_Three        H C (O) CH₂CF_Three
3-CF_Three                  CF_Three          H H C (O) (E-6a)
3-CF_Three                  CF_Three          CH_Three        H C (O) (E-6a)
3-CF_Three                  CF_Three          H H C (O) NHEt
3-CF_Three                  CF_Three          H H C (O) NHPr-c
3-CF_Three                  CF_Three          CH_Three        H C (O) NHPr-c
3-CF_Three                  CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-CF_Three                  CF₂Cl H H C (O) Et
3-CF_Three                  CF₂Cl H H C (O) Pr-n
3-CF_Three                  CF₂Cl H H C (O) Pr-c
3-CF_Three                  CF₂Cl H H C (O) CH₂Pr-c
3-CF_Three                  CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-CF_Three                  CF₂Cl H H C (O) CH₂CF_Three
3-CF_Three                  CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-CF_Three                  CF₂Cl H H C (O) (E-6a)
3-CF_Three                  CF₂Cl CH_Three        H C (O) (E-6a)
3-CF_Three                  CF₂Cl CH_Three        H C (O) NHPr-c
3-CF_Three                  CF₂Br H H C (O) Pr-c
3-CF_Three                  CF₂CHF₂      H H C (O) CH₂Pr-c
3-CF_Three                  CF₂CF_Three       H H C (O) CH₂CF_Three
3-CF₂CF_Three               CHF₂         H H C (O) (E-6a)
3-CF₂CF_Three               CF_Three          H H C (O) Et
3-CF₂CF_Three               CF_Three          H H C (O) Pr-n
3-CF₂CF_Three               CF_Three          H H C (O) Pr-i
3-CF₂CF_Three               CF_Three          H H C (O) Pr-c
3-CF₂CF_Three               CF_Three          CH_Three        H C (O) Pr-c
3-CF₂CF_Three               CF_Three          H H C (O) Bu-i
3-CF₂CF_Three               CF_Three          H H C (O) CH₂Pr-c
3-CF₂CF_Three               CF_Three          CH_Three        H C (O) CH₂Pr-c
3-CF₂CF_Three               CF_Three          H H C (O) CH₂CF_Three
3-CF₂CF_Three               CF_Three          CH_Three        H C (O) CH₂CF_Three
3-CF₂CF_Three               CF_Three          H H C (O) (E-6a)
3-CF₂CF_Three               CF_Three          CH_Three        H C (O) (E-6a)
3-CF₂CF_Three               CF_Three          H H C (O) NHPr-c
3-CF₂CF_Three               CF_Three          CH_Three        H C (O) NHPr-c
3-CF₂CF_Three               CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-CF₂CF_Three               CF₂Cl H H C (O) Pr-n
3-CF₂CF_Three               CF₂Cl H H C (O) Pr-c
3-CF₂CF_Three               CF₂Cl H H C (O) CH₂Pr-c
3-CF₂CF_Three               CF₂Cl H H C (O) CH₂CF_Three
3-CF₂CF_Three               CF₂Cl H H C (O) (E-6a)
3-CF₂CF₂CF_Three            CF_Three          H H C (O) Et
3-CF₂CF₂CF_Three            CF_Three          H H C (O) Pr-n
3-CF₂CF₂CF_Three            CF_Three          H H C (O) Pr-c
3-CF₂CF₂CF_Three            CF_Three          H H C (O) CH₂Pr-c
3-CF₂CF₂CF_Three            CF_Three          CH_Three        H C (O) CH₂Pr-c
3-CF₂CF₂CF_Three            CF_Three          H H C (O) CH₂CF_Three
3-CF₂CF₂CF_Three            CF_Three          CH_Three        H C (O) CH₂CF_Three
3-CF₂CF₂CF_Three            CF_Three          H H C (O) (E-6a)
3-CF₂CF₂CF_Three            CF_Three          CH_Three        H C (O) (E-6a)
3-CF₂CF₂CF_Three            CF_Three          CH_Three        H C (O) NHPr-c
3-CF₂CF₂CF_Three            CF₂Cl H H C (O) Pr-n
3-CF (CF_Three)₂             CF_Three          H H C (O) Et
3-CF (CF_Three)₂             CF_Three          H H C (O) Pr-n
3-CF (CF_Three)₂             CF_Three          H H C (O) Pr-c
3-CF (CF_Three)₂             CF_Three          H H C (O) CH₂Pr-c
3-CF (CF_Three)₂             CF_Three          CH_Three        H C (O) CH₂Pr-c
3-CF (CF_Three)₂             CF_Three          H H C (O) CH₂CF_Three
3-CF (CF_Three)₂             CF_Three          CH_Three        H C (O) CH₂CF_Three
3-CF (CF_Three)₂             CF_Three          H H C (O) (E-6a)
3-CF (CF_Three)₂             CF_Three          CH_Three        H C (O) (E-6a)
3-CF (CF_Three)₂             CF_Three          CH_Three        H C (O) NHPr-c
3-CF (CF_Three)₂             CF₂Cl H H C (O) Pr-c
3-CF₂CF₂CF₂CF_Three         CF_Three          H H C (O) Pr-n
3-CF₂CF₂CF₂CF_Three         CF_Three          H H C (O) Pr-c
3-CF₂CF₂CF₂CF_Three         CF_Three          H H C (O) CH₂Pr-c
3-CF₂CF₂CF₂CF_Three         CF_Three          H H C (O) CH₂CF_Three
3-CF₂CF₂CF₂CF_Three         CF_Three          H H C (O) (E-6a)
3-CH₂OCH₂CF_Three           CF_Three          H H C (O) CH₂Pr-c
3-CH₂SCH_Three              CF_Three          H H C (O) CH₂CF_Three
3-CH₂SPr-i CF_Three          H H C (O) (E-6a)
3-CH₂SPr-c CF_Three          H H C (O) Pr-n
3-CH₂SCF_Three              CF_Three          H H C (O) Pr-c
3-CH₂S (O) CF_Three           CF_Three          H H C (O) CH₂Pr-c
3-CH₂SO₂CF_Three            CF_Three          H H C (O) CH₂CF_Three
3-CH₂SCH₂CF_Three           CF_Three          H H C (O) (E-6a)
3-C (CF_Three)₂OH CF_Three          H H C (O) Pr-n
3-C (CF_Three)₂OH CF_Three          H H C (O) Pr-c
3-C (CF_Three)₂OH CF_Three          H H C (O) CH₂Pr-c
3-C (CF_Three)₂OH CF_Three          H H C (O) CH₂CF_Three
3-C (CF_Three)₂OH CF_Three          H H C (O) (E-6a)
3-C (CF_Three)₂OCH_Three          CF_Three          H H C (O) Pr-n
3-C (CF_Three)₂OCH_Three          CF_Three          H H C (O) Pr-c
3-C (CF_Three)₂OCH_Three          CF_Three          H H C (O) CH₂Pr-c
3-C (CF_Three)₂OCH_Three          CF_Three          H H C (O) CH₂CF_Three
3-C (CF_Three)₂OCH_Three          CF_Three          H H C (O) (E-6a)
3- (T-8) CF_Three          H H C (O) Pr-n
3- (T-9) CF_Three          H H C (O) Pr-c
3- (T-10) CF_Three          H H C (O) CH₂Pr-c
3-OCHF₂                CF_Three          H H C (O) CH₂CF_Three
4-OCHF₂                CF_Three          H H C (O) (E-6a)
3-OCF_Three                 CHF₂         H H C (O) Pr-n
3-OCF_Three                 CF_Three          H H C (O) Et
3-OCF_Three                 CF_Three          H H C (O) Pr-n
3-OCF_Three                 CF_Three          H H C (O) Pr-i
3-OCF_Three                 CF_Three          H H C (O) Pr-c
3-OCF_Three                 CF_Three          CH_Three        H C (O) Pr-c
3-OCF_Three                 CF_Three          H H C (O) Bu-i
3-OCF_Three                 CF_Three          H H C (O) CH₂Pr-c
3-OCF_Three                 CF_Three          CH_Three        H C (O) CH₂Pr-c
3-OCF_Three                 CF_Three          H H C (O) CH₂CF_Three
3-OCF_Three                 CF_Three          CH_Three        H C (O) CH₂CF_Three
3-OCF_Three                 CF_Three          H H C (O) (E-6a)
3-OCF_Three                 CF_Three          CH_Three        H C (O) (E-6a)
3-OCF_Three                 CF_Three          H H C (O) NHPr-c
3-OCF_Three                 CF_Three          CH_Three        H C (O) NHPr-c
3-OCF_Three                 CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-OCF_Three                 CF₂Cl H H C (O) Pr-n
3-OCF_Three                 CF₂Cl H H C (O) Pr-c
3-OCF_Three                 CF₂Cl H H C (O) CH₂Pr-c
3-OCF_Three                 CF₂Cl H H C (O) CH₂CF_Three
3-OCF_Three                 CF₂Cl H H C (O) (E-6a)
3-OCF₂Br CF_Three          H H C (O) Et
3-OCF₂Br CF_Three          H H C (O) Pr-n
3-OCF₂Br CF_Three          H H C (O) Pr-c
3-OCF₂Br CF_Three          H H C (O) CH₂Pr-c
3-OCF₂Br CF_Three          CH_Three        H C (O) CH₂Pr-c
3-OCF₂Br CF_Three          H H C (O) CH₂CF_Three
3-OCF₂Br CF_Three          CH_Three        H C (O) CH₂CF_Three
3-OCF₂Br CF_Three          H H C (O) (E-6a)
3-OCF₂Br CF_Three          CH_Three        H C (O) (E-6a)
3-OCF₂Br CF_Three          CH_Three        H C (O) NHPr-c
3-OCF₂Br CF₂Cl H H C (O) Pr-c
3-OCH₂CF_Three              CF_Three          H H C (O) CH₂Pr-c
3-OCF₂CHF₂             CF_Three          H H C (O) Pr-n
3-OCF₂CHF₂             CF_Three          H H C (O) Pr-c
3-OCF₂CHF₂             CF_Three          H H C (O) CH₂Pr-c
3-OCF₂CHF₂             CF_Three          H H C (O) CH₂CF_Three
3-OCF₂CHF₂             CF_Three          H H C (O) (E-6a)
3-OCF₂CHFCl CF_Three          H H C (O) Pr-n
3-OCF₂CHFCl CF_Three          H H C (O) Pr-c
3-OCF₂CHFCl CF_Three          H H C (O) CH₂Pr-c
3-OCF₂CHFCl CF_Three          H H C (O) CH₂CF_Three
3-OCF₂CHFCl CF_Three          H H C (O) (E-6a)
3-OCF₂CHFBr CF_Three          H H C (O) CH₂CF_Three
3-OCF₂CF₂Br CF_Three          H H C (O) (E-6a)
3-OCF₂CFCl₂            CF_Three          H H C (O) Pr-n
3-OCF₂CCl_Three             CF_Three          H H C (O) Pr-c
3-OCF₂CHFCF_Three           CF_Three          H H C (O) Pr-n
3-OCF₂CHFCF_Three           CF_Three          H H C (O) Pr-c
3-OCF₂CHFCF_Three           CF_Three          H H C (O) CH₂Pr-c
3-OCF₂CHFCF_Three           CF_Three          H H C (O) CH₂CF_Three
3-OCF₂CHFCF_Three           CF_Three          H H C (O) (E-6a)
3-OCH₂CF₂CHF₂          CF_Three          H H C (O) CH₂Pr-c
3-OCH (CF_Three)₂            CF_Three          H H C (O) CH₂CF_Three
3-OCF₂CFBrCF_Three          CF_Three          H H C (O) (E-6a)
3-OCF₂CHFOCF_Three          CF_Three          H H C (O) Pr-n
3-OCF₂CHFOCF_Three          CF_Three          H H C (O) Pr-c
3-OCF₂CHFOCF_Three          CF_Three          H H C (O) CH₂Pr-c
3-OCF₂CHFOCF_Three          CF_Three          H H C (O) CH₂CF_Three
3-OCF₂CHFOCF_Three          CF_Three          H H C (O) (E-6a)
3-OCF₂CHFOCF₂CF₂CF_Three    CF_Three          H H C (O) Pr-n
3-OCH₂CH = CF₂           CF_Three          H H C (O) Pr-c
3-OCH₂CF = CF₂           CF_Three          H H C (O) CH₂Pr-c
3-OCH₂CH = CCl₂          CF_Three          H H C (O) CH₂CF_Three
3-OCH₂CCl = CCl₂         CF_Three          H H C (O) (E-6a)
3-OSO₂CF_Three              CF_Three          H H C (O) Pr-n
3-OSO₂CH₂CF_Three           CF_Three          H H C (O) Pr-c
3-OPh CF_Three          H H C (O) CH₂Pr-c
3-O (D-21c) Br CF_Three          H H C (O) CH₂CF_Three
3-O (D-21c) CF_Three          CF_Three          H H C (O) (E-6a)
3-O (D-52d) Br CF_Three          H H C (O) Pr-n
3-O (D-52d) CF_Three          CF_Three          H H C (O) Pr-c
3-O (D-55c) Br CF_Three          H H C (O) CH₂Pr-c
3-SCH_Three                 CF_Three          H H C (O) CH₂CF_Three
3-S (O) CH_Three              CF_Three          H H C (O) (E-6a)
3-SO₂CH_Three               CF_Three          H H C (O) Pr-n
4-SCH_Three                 CF_Three          H H C (O) Pr-c
3-SPr-i CF_Three          H H C (O) CH₂Pr-c
3-S (O) Pr-i CF_Three          H H C (O) CH₂CF_Three
3-SO₂Pr-i CF_Three          H H C (O) (E-6a)
3-SCH₂F CF_Three          H H C (O) Pr-n
3-S (O) CH₂F CF_Three          H H C (O) Pr-c
3-SO₂CH₂F CF_Three          H H C (O) CH₂Pr-c
3-SCHF₂                CF_Three          H H C (O) CH₂CF_Three
3-S (O) CHF₂             CF_Three          H H C (O) (E-6a)
3-SO₂CHF₂              CF_Three          H H C (O) Pr-n
3-SCF_Three                 CHF₂         H H C (O) Pr-c
3-SCF_Three                 CF_Three          H H C (O) Et
3-SCF_Three                 CF_Three          H H C (O) Pr-n
3-SCF_Three                 CF_Three          H H C (O) Pr-i
3-SCF_Three                 CF_Three          H H C (O) Pr-c
3-SCF_Three                 CF_Three          CH_Three        H C (O) Pr-c
3-SCF_Three                 CF_Three          H H C (O) Bu-i
3-SCF_Three                 CF_Three          H H C (O) CH₂Pr-c
3-SCF_Three                 CF_Three          CH_Three        H C (O) CH₂Pr-c
3-SCF_Three                 CF_Three          H H C (O) CH₂CF_Three
3-SCF_Three                 CF_Three          CH_Three        H C (O) CH₂CF_Three
3-SCF_Three                 CF_Three          H H C (O) (E-6a)
3-SCF_Three                 CF_Three          CH_Three        H C (O) (E-6a)
3-SCF_Three                 CF_Three          H H C (O) NHPr-c
3-SCF_Three                 CF_Three          CH_Three        H C (O) NHPr-c
3-SCF_Three                 CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-SCF_Three                 CF₂Cl H H C (O) Pr-n
3-SCF_Three                 CF₂Cl H H C (O) Pr-c
3-SCF_Three                 CF₂Cl H H C (O) CH₂Pr-c
3-SCF_Three                 CF₂Cl H H C (O) CH₂CF_Three
3-SCF_Three                 CF₂Cl H H C (O) (E-6a)
3-S (O) CF_Three              CF_Three          H H C (O) CH₂Pr-c
3-SO₂CF_Three               CF_Three          H H C (O) CH₂CF_Three
3-SCF₂Cl CF_Three          H H C (O) Et
3-SCF₂Cl CF_Three          H H C (O) Pr-n
3-SCF₂Cl CF_Three          H H C (O) Pr-c
3-SCF₂Cl CF_Three          H H C (O) CH₂Pr-c
3-SCF₂Cl CF_Three          CH_Three        H C (O) CH₂Pr-c
3-SCF₂Cl CF_Three          H H C (O) CH₂CF_Three
3-SCF₂Cl CF_Three          CH_Three        H C (O) CH₂CF_Three
3-SCF₂Cl CF_Three          H H C (O) (E-6a)
3-SCF₂Cl CF_Three          CH_Three        H C (O) (E-6a)
3-SCF₂Cl CF_Three          CH_Three        H C (O) NHPr-c
3-SCF₂Cl CF₂Cl H H C (O) (E-6a)
3-S (O) CF₂Cl CF_Three          H H C (O) Pr-n
3-SO₂CF₂Cl CF_Three          H H C (O) Pr-c
3-SCF₂Br CF_Three          H H C (O) Et
3-SCF₂Br CF_Three          H H C (O) Pr-n
3-SCF₂Br CF_Three          H H C (O) Pr-c
3-SCF₂Br CF_Three          H H C (O) CH₂Pr-c
3-SCF₂Br CF_Three          CH_Three        H C (O) CH₂Pr-c
3-SCF₂Br CF_Three          H H C (O) CH₂CF_Three
3-SCF₂Br CF_Three          CH_Three        H C (O) CH₂CF_Three
3-SCF₂Br CF_Three          H H C (O) (E-6a)
3-SCF₂Br CF_Three          CH_Three        H C (O) (E-6a)
3-SCF₂Br CF_Three          CH_Three        H C (O) NHPr-c
3-SCF₂Br CF₂Cl H H C (O) CH₂Pr-c
3-S (O) CF₂Br CF_Three          H H C (O) CH₂CF_Three
3-SO₂CF₂Br CF_Three          H H C (O) (E-6a)
3-SCH₂CF_Three              CF_Three          H H C (O) Pr-n
3-SCF₂CHF₂             CF_Three          H H C (O) Pr-c
3-SCF₂CHFCl CF_Three          H H C (O) CH₂Pr-c
3-SCF₂CF_Three              CF_Three          H H C (O) CH₂CF_Three
3-SCF₂CF₂Br CF_Three          H H C (O) (E-6a)
3-SCF₂CHFCF_Three           CF_Three          H H C (O) Pr-n
3-SCF₂CF₂CF_Three           CF_Three          H H C (O) Pr-c
3-SPh CF_Three          H H C (O) CH₂Pr-c
3-S (D-21c) Br CF_Three          H H C (O) CH₂CF_Three
3-S (D-21c) CF_Three          CF_Three          H H C (O) (E-6a)
3-S (D-52d) Br CF_Three          H H C (O) Pr-n
3-S (D-52d) CF_Three          CF_Three          H H C (O) Pr-c
3-S (D-55c) Br CF_Three          H H C (O) CH₂Pr-c
3-SF_Five                  CHF₂         H H C (O) CH₂CF_Three
3-SF_Five                  CF_Three          H H C (O) Et
3-SF_Five                  CF_Three          H H C (O) Pr-n
3-SF_Five                  CF_Three          H H C (O) Pr-i
3-SF_Five                  CF_Three          H H C (O) Pr-c
3-SF_Five                  CF_Three          CH_Three        H C (O) Pr-c
3-SF_Five                  CF_Three          H H C (O) Bu-i
3-SF_Five                  CF_Three          H H C (O) CH₂Pr-c
3-SF_Five                  CF_Three          CH_Three        H C (O) CH₂Pr-c
3-SF_Five                  CF_Three          H H C (O) CH₂CF_Three
3-SF_Five                  CF_Three          CH_Three        H C (O) CH₂CF_Three
3-SF_Five                  CF_Three          H H C (O) (E-6a)
3-SF_Five                  CF_Three          CH_Three        H C (O) (E-6a)
3-SF_Five                  CF_Three          H H C (O) NHPr-c
3-SF_Five                  CF_Three          CH_Three        H C (O) NHPr-c
3-SF_Five                  CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-SF_Five                  CF₂Cl H H C (O) Pr-n
3-SF_Five                  CF₂Cl H H C (O) Pr-c
3-SF_Five                  CF₂Cl H H C (O) CH₂Pr-c
3-SF_Five                  CF₂Cl H H C (O) CH₂CF_Three
3-SF_Five                  CF₂Cl H H C (O) (E-6a)
3-NO₂                  CF_Three          H H C (O) (E-6a)
3-CN CF_Three          H H C (O) Pr-n
3-C (S) NH₂              CF_Three          H H C (O) Pr-c
3-Si (CH_Three)_Three             CF_Three          H H C (O) CH₂Pr-c
3,4-F₂                 CF_Three          H H C (O) Pr-n
3,4-F₂                 CF_Three          H H C (O) Pr-c
3,4-F₂                 CF_Three          H H C (O) CH₂Pr-c
3,4-F₂                 CF_Three          H H C (O) CH₂CF_Three
3,4-F₂                 CF_Three          H H C (O) (E-6a)
3,5-F₂                 CF_Three          H H C (O) Pr-n
3,5-F₂                 CF_Three          H H C (O) Pr-c
3,5-F₂                 CF_Three          H H C (O) CH₂Pr-c
3,5-F₂                 CF_Three          H H C (O) CH₂CF_Three
3,5-F₂                 CF_Three          H H C (O) (E-6a)
3-Cl-4-F CHF₂         H H C (O) Pr-n
3-Cl-4-F CHF₂         H H C (O) Pr-c
3-Cl-4-F CHF₂         H H C (O) CH₂Pr-c
3-Cl-4-F CHF₂         H H C (O) CH₂CF_Three
3-Cl-4-F CHF₂         H H C (O) (E-6a)
3-Cl-4-F CF_Three          H H C (O) Et
3-Cl-4-F CF_Three          H Et C (O) Et
3-Cl-4-F CF_Three          H CH₂C≡CH C (O) Et
3-Cl-4-F CF_Three          CH_Three        H C (O) Et
3-Cl-4-F CF_Three          H H C (O) Pr-n
3-Cl-4-F CF_Three          H Et C (O) Pr-n
3-Cl-4-F CF_Three          CH_Three        H C (O) Pr-n
3-Cl-4-F CF_Three          H H C (O) Pr-i
3-Cl-4-F CF_Three          CH_Three        H C (O) Pr-i
3-Cl-4-F CF_Three          H H C (O) Pr-c
3-Cl-4-F CF_Three          H Et C (O) Pr-c
3-Cl-4-F CF_Three          H CH₂Pr-c C (O) Pr-c
3-Cl-4-F CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-Cl-4-F CF_Three          H CH₂C≡CH C (O) Pr-c
3-Cl-4-F CF_Three          CH_Three        H C (O) Pr-c
3-Cl-4-F CF_Three          CH_Three        Et C (O) Pr-c
3-Cl-4-F CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-Cl-4-F CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-Cl-4-F CF_Three          H H C (O) Bu-i
3-Cl-4-F CF_Three          H H C (O) CH₂Pr-c
3-Cl-4-F CF_Three          H Et C (O) CH₂Pr-c
3-Cl-4-F CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Cl-4-F CF_Three          H H C (O) CH₂CF_Three
3-Cl-4-F CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Cl-4-F CF_Three          H H C (O) (E-6a)
3-Cl-4-F CF_Three          CH_Three        H C (O) (E-6a)
3-Cl-4-F CF_Three          H H C (O) NHEt
3-Cl-4-F CF_Three          H H C (O) NHPr-c
3-Cl-4-F CF_Three          CH_Three        H C (O) NHPr-c
3-Cl-4-F CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Cl-4-F CF₂Cl H H C (O) Et
3-Cl-4-F CF₂Cl H H C (O) Pr-n
3-Cl-4-F CF₂Cl H H C (O) Pr-c
3-Cl-4-F CF₂Cl H H C (O) CH₂Pr-c
3-Cl-4-F CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-Cl-4-F CF₂Cl H H C (O) CH₂CF_Three
3-Cl-4-F CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-Cl-4-F CF₂Cl H H C (O) (E-6a)
3-Cl-4-F CF₂Cl CH_Three        H C (O) (E-6a)
3-Cl-4-F CF₂Cl CH_Three        H C (O) NHPr-c
3-Cl-4-F CF₂Br H H C (O) CH₂CF_Three
3-Cl-4-F CF₂CHF₂      H H C (O) (E-6a)
3-Cl-4-F CF₂CF_Three       H H C (O) Pr-n
3-F-4-Cl CF_Three          H H C (O) Pr-c
3-F-5-Cl CHF₂         H H C (O) Pr-n
3-F-5-Cl CHF₂         H H C (O) Pr-c
3-F-5-Cl CHF₂         H H C (O) CH₂Pr-c
3-F-5-Cl CHF₂         H H C (O) CH₂CF_Three
3-F-5-Cl CHF₂         H H C (O) (E-6a)
3-F-5-Cl CF_Three          H H C (O) Et
3-F-5-Cl CF_Three          H Et C (O) Et
3-F-5-Cl CF_Three          H CH₂C≡CH C (O) Et
3-F-5-Cl CF_Three          CH_Three        H C (O) Et
3-F-5-Cl CF_Three          H H C (O) Pr-n
3-F-5-Cl CF_Three          H Et C (O) Pr-n
3-F-5-Cl CF_Three          CH_Three        H C (O) Pr-n
3-F-5-Cl CF_Three          H H C (O) Pr-i
3-F-5-Cl CF_Three          CH_Three        H C (O) Pr-i
3-F-5-Cl CF_Three          H H C (O) Pr-c
3-F-5-Cl CF_Three          H Et C (O) Pr-c
3-F-5-Cl CF_Three          H CH₂Pr-c C (O) Pr-c
3-F-5-Cl CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-F-5-Cl CF_Three          H CH₂C≡CH C (O) Pr-c
3-F-5-Cl CF_Three          CH_Three        H C (O) Pr-c
3-F-5-Cl CF_Three          CH_Three        Et C (O) Pr-c
3-F-5-Cl CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-F-5-Cl CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-F-5-Cl CF_Three          H H C (O) Bu-i
3-F-5-Cl CF_Three          H H C (O) CH₂Pr-c
3-F-5-Cl CF_Three          H Et C (O) CH₂Pr-c
3-F-5-Cl CF_Three          CH_Three        H C (O) CH₂Pr-c
3-F-5-Cl CF_Three          H H C (O) CH₂CF_Three
3-F-5-Cl CF_Three          CH_Three        H C (O) CH₂CF_Three
3-F-5-Cl CF_Three          H H C (O) (E-6a)
3-F-5-Cl CF_Three          CH_Three        H C (O) (E-6a)
3-F-5-Cl CF_Three          H H C (O) NHEt
3-F-5-Cl CF_Three          H H C (O) NHPr-c
3-F-5-Cl CF_Three          CH_Three        H C (O) NHPr-c
3-F-5-Cl CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-F-5-Cl CF₂Cl H H C (O) Et
3-F-5-Cl CF₂Cl H H C (O) Pr-n
3-F-5-Cl CF₂Cl H H C (O) Pr-c
3-F-5-Cl CF₂Cl H H C (O) CH₂Pr-c
3-F-5-Cl CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-F-5-Cl CF₂Cl H H C (O) CH₂CF_Three
3-F-5-Cl CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-F-5-Cl CF₂Cl H H C (O) (E-6a)
3-F-5-Cl CF₂Cl CH_Three        H C (O) (E-6a)
3-F-5-Cl CF₂Cl CH_Three        H C (O) NHPr-c
3-F-5-Cl CF₂Br H H C (O) CH₂Pr-c
3-F-5-Cl CF₂CHF₂      H H C (O) CH₂CF_Three
3-F-5-Cl CF₂CF_Three       H H C (O) (E-6a)
3,4-Cl₂                CHF₂         H H C (O) Pr-n
3,4-Cl₂                CHF₂         H H C (O) Pr-c
3,4-Cl₂                CHF₂         H H C (O) CH₂Pr-c
3,4-Cl₂                CHF₂         H H C (O) CH₂CF_Three
3,4-Cl₂                CHF₂         H H C (O) (E-6a)
3,4-Cl₂                CF_Three          H H C (O) Et
3,4-Cl₂                CF_Three          H Et C (O) Et
3,4-Cl₂                CF_Three          H CH₂C≡CH C (O) Et
3,4-Cl₂                CF_Three          CH_Three        H C (O) Et
3,4-Cl₂                CF_Three          H H C (O) Pr-n
3,4-Cl₂                CF_Three          H Et C (O) Pr-n
3,4-Cl₂                CF_Three          CH_Three        H C (O) Pr-n
3,4-Cl₂                CF_Three          H H C (O) Pr-i
3,4-Cl₂                CF_Three          CH_Three        H C (O) Pr-i
3,4-Cl₂                CF_Three          H H C (O) Pr-c
3,4-Cl₂                CF_Three          H Et C (O) Pr-c
3,4-Cl₂                CF_Three          H CH₂Pr-c C (O) Pr-c
3,4-Cl₂                CF_Three          H CH₂OCH_Three    C (O) Pr-c
3,4-Cl₂                CF_Three          H CH₂C≡CH C (O) Pr-c
3,4-Cl₂                CF_Three          CH_Three        H C (O) Pr-c
3,4-Cl₂                CF_Three          CH_Three        Et C (O) Pr-c
3,4-Cl₂                CF_Three          CH_Three        CH₂CN C (O) Pr-c
3,4-Cl₂                CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3,4-Cl₂                CF_Three          H H C (O) Bu-i
3,4-Cl₂                CF_Three          H H C (O) CH₂Pr-c
3,4-Cl₂                CF_Three          H Et C (O) CH₂Pr-c
3,4-Cl₂                CF_Three          CH_Three        H C (O) CH₂Pr-c
3,4-Cl₂                CF_Three          H H C (O) CH₂CF_Three
3,4-Cl₂                CF_Three          CH_Three        H C (O) CH₂CF_Three
3,4-Cl₂                CF_Three          H H C (O) (E-6a)
3,4-Cl₂                CF_Three          CH_Three        H C (O) (E-6a)
3,4-Cl₂                CF_Three          H H C (O) NHEt
3,4-Cl₂                CF_Three          H H C (O) NHPr-c
3,4-Cl₂                CF_Three          CH_Three        H C (O) NHPr-c
3,4-Cl₂                CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,4-Cl₂                CF₂Cl H H C (O) Et
3,4-Cl₂                CF₂Cl H H C (O) Pr-n
3,4-Cl₂                CF₂Cl H H C (O) Pr-c
3,4-Cl₂                CF₂Cl H H C (O) CH₂Pr-c
3,4-Cl₂                CF₂Cl CH_Three        H C (O) CH₂Pr-c
3,4-Cl₂                CF₂Cl H H C (O) CH₂CF_Three
3,4-Cl₂                CF₂Cl CH_Three        H C (O) CH₂CF_Three
3,4-Cl₂                CF₂Cl H H C (O) (E-6a)
3,4-Cl₂                CF₂Cl CH_Three        H C (O) (E-6a)
3,4-Cl₂                CF₂Cl CH_Three        H C (O) NHPr-c
3,4-Cl₂                CF₂Br H H C (O) Pr-n
3,4-Cl₂                CF₂CHF₂      H H C (O) Pr-c
3,4-Cl₂                CF₂CF_Three       H H C (O) CH₂Pr-c
3,5-Cl₂                CHF₂         H H C (O) Et
3,5-Cl₂                CHF₂         H H C (O) Pr-n
3,5-Cl₂                CHF₂         H H C (O) Pr-c
3,5-Cl₂                CHF₂         H H C (O) CH₂Pr-c
3,5-Cl₂                CHF₂         CH_Three        H C (O) CH₂Pr-c
3,5-Cl₂                CHF₂         H H C (O) CH₂CF_Three
3,5-Cl₂                CHF₂         CH_Three        H C (O) CH₂CF_Three
3,5-Cl₂                CHF₂         H H C (O) (E-6a)
3,5-Cl₂                CHF₂         CH_Three        H C (O) (E-6a)
3,5-Cl₂                CHF₂         H H C (O) CH₂SCH_Three
3,5-Cl₂                CHF₂         H H C (O) CH₂S (O) CH_Three
3,5-Cl₂                CHF₂         H H C (O) CH₂SO₂CH_Three
3,5-Cl₂                CHF₂         H H C (O) CH₂SEt
3,5-Cl₂                CHF₂         H H C (O) CH₂S (O) Et
3,5-Cl₂                CHF₂         H H C (O) CH₂SO₂Et
3,5-Cl₂                CHF₂         CH_Three        H C (O) NHPr-c
3,5-Cl₂                CF_Three          H H H
3,5-Cl₂                CF_Three          CH_Three        H H
3,5-Cl₂                CF_Three          CN H H
3,5-Cl₂                CF_Three          H H C (O) CH_Three
3,5-Cl₂                CF_Three          H H C (O) Et
3,5-Cl₂                CF_Three          H Et C (O) Et
3,5-Cl₂                CF_Three          H CH₂Pr-c C (O) Et
3,5-Cl₂                CF_Three          H CH₂OCH_Three    C (O) Et
3,5-Cl₂                CF_Three          H CH₂CN C (O) Et
3,5-Cl₂                CF_Three          H CH₂CH = CH₂  C (O) Et
3,5-Cl₂                CF_Three          H CH₂C≡CH C (O) Et
3,5-Cl₂                CF_Three          CH_Three        H C (O) Et
3,5-Cl₂                CF_Three          CH_Three        Et C (O) Et
3,5-Cl₂                CF_Three          CH_Three        CH₂Pr-c C (O) Et
3,5-Cl₂                CF_Three          CH_Three        CH₂OCH_Three    C (O) Et
3,5-Cl₂                CF_Three          CH_Three        CH₂CN C (O) Et
3,5-Cl₂                CF_Three          CH_Three        CH₂C≡CH C (O) Et
3,5-Cl₂                CF_Three          H H C (O) Pr-n
3,5-Cl₂                CF_Three          H Et C (O) Pr-n
3,5-Cl₂                CF_Three          H CH₂Pr-c C (O) Pr-n
3,5-Cl₂                CF_Three          H CH₂OCH_Three    C (O) Pr-n
3,5-Cl₂                CF_Three          H CH₂CN C (O) Pr-n
3,5-Cl₂                CF_Three          H CH₂C≡CH C (O) Pr-n
3,5-Cl₂                CF_Three          CH_Three        H C (O) Pr-n
3,5-Cl₂                CF_Three          CF_Three        H C (O) Pr-n
3,5-Cl₂                CF_Three          CN H C (O) Pr-n
3,5-Cl₂                CF_Three          C≡CH H C (O) Pr-n
3,5-Cl₂                CF_Three          H H C (O) Pr-i
3,5-Cl₂                CF_Three          CH_Three        H C (O) Pr-i
3,5-Cl₂                CF_Three          H H C (O) Pr-c
3,5-Cl₂                CF_Three          H CH_Three        C (O) Pr-c
3,5-Cl₂                CF_Three          H Et C (O) Pr-c
3,5-Cl₂                CF_Three          H n-Pr C (O) Pr-c
3,5-Cl₂                CF_Three          H CH₂Pr-c C (O) Pr-c
3,5-Cl₂                CF_Three          H CH₂OCH_Three    C (O) Pr-c
3,5-Cl₂                CF_Three          H CH₂CN C (O) Pr-c
3,5-Cl₂                CF_Three          H CH₂CH = CH₂  C (O) Pr-c
3,5-Cl₂                CF_Three          H CH₂C≡CH C (O) Pr-c
3,5-Cl₂                CF_Three          CH_Three        H C (O) Pr-c
3,5-Cl₂                CF_Three          CH_Three        Et C (O) Pr-c
3,5-Cl₂                CF_Three          CH_Three        CH₂Pr-c C (O) Pr-c
3,5-Cl₂                CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-c
3,5-Cl₂                CF_Three          CH_Three        CH₂CN C (O) Pr-c
3,5-Cl₂                CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3,5-Cl₂                CF_Three          CF_Three        H C (O) Pr-c
3,5-Cl₂                CF_Three          CN H C (O) Pr-c
3,5-Cl₂                CF_Three          C≡CH H C (O) Pr-c
3,5-Cl₂                CF_Three          H H C (O) Bu-i
3,5-Cl₂                CF_Three          H H C (O) CH₂Pr-c
3,5-Cl₂                CF_Three          H Et C (O) CH₂Pr-c
3,5-Cl₂                CF_Three          H CH₂Pr-c C (O) CH₂Pr-c
3,5-Cl₂                CF_Three          H CH₂OCH_Three    C (O) CH₂Pr-c
3,5-Cl₂                CF_Three          H CH₂CN C (O) CH₂Pr-c
3,5-Cl₂                CF_Three          H CH₂CH = CH₂  C (O) CH₂Pr-c
3,5-Cl₂                CF_Three          H CH₂C≡CH C (O) CH₂Pr-c
3,5-Cl₂                CF_Three          CH_Three        H C (O) CH₂Pr-c
3,5-Cl₂                CF_Three          CF_Three        H C (O) CH₂Pr-c
3,5-Cl₂                CF_Three          CN H C (O) CH₂Pr-c
3,5-Cl₂                CF_Three          C≡CH H C (O) CH₂Pr-c
3,5-Cl₂                CF_Three          H H C (O) (T-1)
3,5-Cl₂                CF_Three          CH_Three        H C (O) (T-1)
3,5-Cl₂                CF_Three          H H C (O) Bu-c
3,5-Cl₂                CF_Three          H H C (O) CH₂CF_Three
3,5-Cl₂                CF_Three          H Et C (O) CH₂CF_Three
3,5-Cl₂                CF_Three          H CH₂Pr-c C (O) CH₂CF_Three
3,5-Cl₂                CF_Three          H CH₂OCH_Three    C (O) CH₂CF_Three
3,5-Cl₂                CF_Three          H CH₂CN C (O) CH₂CF_Three
3,5-Cl₂                CF_Three          H CH₂C≡CH C (O) CH₂CF_Three
3,5-Cl₂                CF_Three          CH_Three        H C (O) CH₂CF_Three
3,5-Cl₂                CF_Three          CF_Three        H C (O) CH₂CF_Three
3,5-Cl₂                CF_Three          CN H C (O) CH₂CF_Three
3,5-Cl₂                CF_Three          C≡CH H C (O) CH₂CF_Three
3,5-Cl₂                CF_Three          H H C (O) CH₂CH₂CF_Three
3,5-Cl₂                CF_Three          H H C (O) (E-6a)
3,5-Cl₂                CF_Three          H Et C (O) (E-6a)
3,5-Cl₂                CF_Three          H CH₂Pr-c C (O) (E-6a)
3,5-Cl₂                CF_Three          H CH₂OCH_Three    C (O) (E-6a)
3,5-Cl₂                CF_Three          H CH₂CN C (O) (E-6a)
3,5-Cl₂                CF_Three          H CH₂C≡CH C (O) (E-6a)
3,5-Cl₂                CF_Three          CH_Three        H C (O) (E-6a)
3,5-Cl₂                CF_Three          CF_Three        H C (O) (E-6a)
3,5-Cl₂                CF_Three          CN H C (O) (E-6a)
3,5-Cl₂                CF_Three          C≡CH H C (O) (E-6a)
3,5-Cl₂                CF_Three          H H C (O) CH₂SCH_Three
3,5-Cl₂                CF_Three          H CH_Three        C (O) CH₂SCH_Three
3,5-Cl₂                CF_Three          H Et C (O) CH₂SCH_Three
3,5-Cl₂                CF_Three          H CH₂C≡CH C (O) CH₂SCH_Three
3,5-Cl₂                CF_Three          CH_Three        H C (O) CH₂SCH_Three
3,5-Cl₂                CF_Three          H H C (O) CH₂S (O) CH_Three
3,5-Cl₂                CF_Three          H CH_Three        C (O) CH₂S (O) CH_Three
3,5-Cl₂                CF_Three          H Et C (O) CH₂S (O) CH_Three
3,5-Cl₂                CF_Three          H CH₂C≡CH C (O) CH₂S (O) CH_Three
3,5-Cl₂                CF_Three          CH_Three        H C (O) CH₂S (O) CH_Three
3,5-Cl₂                CF_Three          H H C (O) CH₂SO₂CH_Three
3,5-Cl₂                CF_Three          H CH_Three        C (O) CH₂SO₂CH_Three
3,5-Cl₂                CF_Three          H Et C (O) CH₂SO₂CH_Three
3,5-Cl₂                CF_Three          H CH₂C≡CH C (O) CH₂SO₂CH_Three
3,5-Cl₂                CF_Three          CH_Three        H C (O) CH₂SO₂CH_Three
3,5-Cl₂                CF_Three          H H C (O) CH₂SEt
3,5-Cl₂                CF_Three          H CH_Three        C (O) CH₂SEt
3,5-Cl₂                CF_Three          H Et C (O) CH₂SEt
3,5-Cl₂                CF_Three          H CH₂CH = CH₂  C (O) CH₂SEt
3,5-Cl₂                CF_Three          H CH₂C≡CH C (O) CH₂SEt
3,5-Cl₂                CF_Three          CH_Three        H C (O) CH₂SEt
3,5-Cl₂                CF_Three          H H C (O) CH₂S (O) Et
3,5-Cl₂                CF_Three          H CH_Three        C (O) CH₂S (O) Et
3,5-Cl₂                CF_Three          H Et C (O) CH₂S (O) Et
3,5-Cl₂                CF_Three          H CH₂C≡CH C (O) CH₂S (O) Et
3,5-Cl₂                CF_Three          CH_Three        H C (O) CH₂S (O) Et
3,5-Cl₂                CF_Three          H H C (O) CH₂SO₂Et
3,5-Cl₂                CF_Three          H CH_Three        C (O) CH₂SO₂Et
3,5-Cl₂                CF_Three          H Et C (O) CH₂SO₂Et
3,5-Cl₂                CF_Three          H CH₂C≡CH C (O) CH₂SO₂Et
3,5-Cl₂                CF_Three          CH_Three        H C (O) CH₂SO₂Et
3,5-Cl₂                CF_Three          H H C (O) CH₂SCH₂CF_Three
3,5-Cl₂                CF_Three          H H C (O) CH₂S (O) CH₂CF_Three
3,5-Cl₂                CF_Three          H H C (O) CH₂SO₂CH₂CF_Three
3,5-Cl₂                CF_Three          H H C (O) CH (CH_Three) SCH_Three
3,5-Cl₂                CF_Three          H H C (O) CH (CH_Three) S (O) CH_Three
3,5-Cl₂                CF_Three          H H C (O) CH (CH_Three) SO₂CH_Three
3,5-Cl₂                CF_Three          H H C (O) CH (CH_Three) SEt
3,5-Cl₂                CF_Three          H H C (O) (E-7a)
3,5-Cl₂                CF_Three          H H C (O) (E-7b)
3,5-Cl₂                CF_Three          H H C (O) (E-7c)
3,5-Cl₂                CF_Three          H H C (O) (E-8a)
3,5-Cl₂                CF_Three          H H C (O) (E-8b)
3,5-Cl₂                CF_Three          H H C (O) (E-8c)
3,5-Cl₂                CF_Three          H H C (O) CH (SCH_Three)₂
3,5-Cl₂                CF_Three          H H C (O) CH (SCH_Three) S (O) CH_Three
3,5-Cl₂                CF_Three          H H C (O) CH [S (O) CH_Three]₂
3,5-Cl₂                CF_Three          H H C (O) CH [S (O) CH_Three] SO₂CH_Three
3,5-Cl₂                CF_Three          H H C (O) CH (SEt)₂
3,5-Cl₂                CF_Three          H H C (O) CH (SEt) S (O) Et
3,5-Cl₂                CF_Three          H H C (O) CH [S (O) Et]₂
3,5-Cl₂                CF_Three          H H C (O) CH [S (O) Et] SO₂Et
3,5-Cl₂                CF_Three          H H C (O) CH₂CH₂C≡CH
3,5-Cl₂                CF_Three          H H C (O) NHEt
3,5-Cl₂                CF_Three          H CH₂CH = CH₂  C (O) NHEt
3,5-Cl₂                CF_Three          H CH₂C≡CH C (O) NHEt
3,5-Cl₂                CF_Three          CH_Three        H C (O) NHEt
3,5-Cl₂                CF_Three          H H C (O) NHPr-c
3,5-Cl₂                CF_Three          CH_Three        H C (O) NHPr-c
3,5-Cl₂                CF_Three          H H C (O) NHCH₂CF_Three
3,5-Cl₂                CF_Three          CH_Three        H C (O) NHCH₂CF_Three
3,5-Cl₂                CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,5-Cl₂                CF_Three          H H C (O) (T-23)
3,5-Cl₂                CF_Three          H H C (O) (T-33)
3,5-Cl₂                CF_Three          H H C (S) CH₂Pr-c
3,5-Cl₂                CF_Three          CH_Three        H C (S) CH₂Pr-c
3,5-Cl₂                CF_Three          H H C (S) CH₂SCH_Three
3,5-Cl₂                CF_Three          H H C (S) CH₂SO₂CH_Three
3,5-Cl₂                CF_Three          H H C (S) CH₂SEt
3,5-Cl₂                CF_Three          H H C (S) CH₂SO₂Et
3,5-Cl₂                CF₂Cl H H C (O) Et
3,5-Cl₂                CF₂Cl H H C (O) Pr-n
3,5-Cl₂                CF₂Cl H H C (O) Pr-i
3,5-Cl₂                CF₂Cl H H C (O) Pr-c
3,5-Cl₂                CF₂Cl CH_Three        H C (O) Pr-c
3,5-Cl₂                CF₂Cl H H C (O) Bu-i
3,5-Cl₂                CF₂Cl H H C (O) CH₂Pr-c
3,5-Cl₂                CF₂Cl CH_Three        H C (O) CH₂Pr-c
3,5-Cl₂                CF₂Cl H H C (O) CH₂CF_Three
3,5-Cl₂                CF₂Cl CH_Three        H C (O) CH₂CF_Three
3,5-Cl₂                CF₂Cl H H C (O) (E-6a)
3,5-Cl₂                CF₂Cl CH_Three        H C (O) (E-6a)
3,5-Cl₂                CF₂Cl H H C (O) CH₂SCH_Three
3,5-Cl₂                CF₂Cl H H C (O) CH₂S (O) CH_Three
3,5-Cl₂                CF₂Cl H H C (O) CH₂SO₂CH_Three
3,5-Cl₂                CF₂Cl H H C (O) CH₂SEt
3,5-Cl₂                CF₂Cl H H C (O) CH₂S (O) Et
3,5-Cl₂                CF₂Cl H H C (O) CH₂SO₂Et
3,5-Cl₂                CF₂Cl H H C (O) NHPr-c
3,5-Cl₂                CF₂Cl CH_Three        H C (O) NHPr-c
3,5-Cl₂                CF₂Cl CH_Three        H C (O) NHCH₂C≡CH
3,5-Cl₂                CF₂Cl H H C (S) CH₂SCH_Three
3,5-Cl₂                CF₂Cl H H C (S) CH₂SO₂CH_Three
3,5-Cl₂                CF₂Cl H H C (S) CH₂SEt
3,5-Cl₂                CF₂Cl H H C (S) CH₂SO₂Et
3,5-Cl₂                CF₂Br H H C (O) Pr-n
3,5-Cl₂                CF₂Br H H C (O) Pr-c
3,5-Cl₂                CF₂Br H H C (O) CH₂Pr-c
3,5-Cl₂                CF₂Br H H C (O) CH₂CF_Three
3,5-Cl₂                CF₂Br H H C (O) (E-6a)
3,5-Cl₂                CF₂CHF₂      H H C (O) Pr-n
3,5-Cl₂                CF₂CHF₂      H H C (O) Pr-c
3,5-Cl₂                CF₂CHF₂      H H C (O) CH₂Pr-c
3,5-Cl₂                CF₂CHF₂      H H C (O) CH₂CF_Three
3,5-Cl₂                CF₂CHF₂      H H C (O) (E-6a)
3,5-Cl₂                CF₂CF_Three       H H C (O) Pr-n
3,5-Cl₂                CF₂CF_Three       H H C (O) Pr-c
3,5-Cl₂                CF₂CF_Three       H H C (O) CH₂Pr-c
3,5-Cl₂                CF₂CF_Three       H H C (O) CH₂CF_Three
3,5-Cl₂                CF₂CF_Three       H H C (O) (E-6a)
3-Br-4-F CHF₂         H H C (O) Pr-n
3-Br-4-F CHF₂         H H C (O) Pr-c
3-Br-4-F CHF₂         H H C (O) CH₂Pr-c
3-Br-4-F CHF₂         H H C (O) CH₂CF_Three
3-Br-4-F CHF₂         H H C (O) (E-6a)
3-Br-4-F CF_Three          H H C (O) Et
3-Br-4-F CF_Three          H Et C (O) Et
3-Br-4-F CF_Three          H CH₂C≡CH C (O) Et
3-Br-4-F CF_Three          CH_Three        H C (O) Et
3-Br-4-F CF_Three          H H C (O) Pr-n
3-Br-4-F CF_Three          H Et C (O) Pr-n
3-Br-4-F CF_Three          CH_Three        H C (O) Pr-n
3-Br-4-F CF_Three          H H C (O) Pr-i
3-Br-4-F CF_Three          CH_Three        H C (O) Pr-i
3-Br-4-F CF_Three          H H C (O) Pr-c
3-Br-4-F CF_Three          H Et C (O) Pr-c
3-Br-4-F CF_Three          H CH₂Pr-c C (O) Pr-c
3-Br-4-F CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-Br-4-F CF_Three          H CH₂C≡CH C (O) Pr-c
3-Br-4-F CF_Three          CH_Three        H C (O) Pr-c
3-Br-4-F CF_Three          CH_Three        Et C (O) Pr-c
3-Br-4-F CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-Br-4-F CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-Br-4-F CF_Three          H H C (O) Bu-i
3-Br-4-F CF_Three          H H C (O) CH₂Pr-c
3-Br-4-F CF_Three          H Et C (O) CH₂Pr-c
3-Br-4-F CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Br-4-F CF_Three          H H C (O) CH₂CF_Three
3-Br-4-F CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Br-4-F CF_Three          H H C (O) (E-6a)
3-Br-4-F CF_Three          CH_Three        H C (O) (E-6a)
3-Br-4-F CF_Three          H H C (O) NHEt
3-Br-4-F CF_Three          H H C (O) NHPr-c
3-Br-4-F CF_Three          CH_Three        H C (O) NHPr-c
3-Br-4-F CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Br-4-F CF₂Cl H H C (O) Et
3-Br-4-F CF₂Cl H H C (O) Pr-n
3-Br-4-F CF₂Cl H H C (O) Pr-c
3-Br-4-F CF₂Cl H H C (O) CH₂Pr-c
3-Br-4-F CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-Br-4-F CF₂Cl H H C (O) CH₂CF_Three
3-Br-4-F CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-Br-4-F CF₂Cl H H C (O) (E-6a)
3-Br-4-F CF₂Cl CH_Three        H C (O) (E-6a)
3-Br-4-F CF₂Cl CH_Three        H C (O) NHPr-c
3-Br-4-F CF₂Br H H C (O) CH₂CF_Three
3-Br-4-F CF₂CHF₂      H H C (O) (E-6a)
3-Br-4-F CF₂CF_Three       H H C (O) Pr-n
3-F-4-Br CF_Three          H H C (O) Pr-c
3-F-5-Br CHF₂         H H C (O) Pr-n
3-F-5-Br CHF₂         H H C (O) Pr-c
3-F-5-Br CHF₂         H H C (O) CH₂Pr-c
3-F-5-Br CHF₂         H H C (O) CH₂CF_Three
3-F-5-Br CHF₂         H H C (O) (E-6a)
3-F-5-Br CF_Three          H H C (O) Et
3-F-5-Br CF_Three          H Et C (O) Et
3-F-5-Br CF_Three          H CH₂C≡CH C (O) Et
3-F-5-Br CF_Three          CH_Three        H C (O) Et
3-F-5-Br CF_Three          H H C (O) Pr-n
3-F-5-Br CF_Three          H Et C (O) Pr-n
3-F-5-Br CF_Three          CH_Three        H C (O) Pr-n
3-F-5-Br CF_Three          H H C (O) Pr-i
3-F-5-Br CF_Three          CH_Three        H C (O) Pr-i
3-F-5-Br CF_Three          H H C (O) Pr-c
3-F-5-Br CF_Three          H Et C (O) Pr-c
3-F-5-Br CF_Three          H CH₂Pr-c C (O) Pr-c
3-F-5-Br CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-F-5-Br CF_Three          H CH₂C≡CH C (O) Pr-c
3-F-5-Br CF_Three          CH_Three        H C (O) Pr-c
3-F-5-Br CF_Three          CH_Three        Et C (O) Pr-c
3-F-5-Br CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-F-5-Br CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-F-5-Br CF_Three          H H C (O) Bu-i
3-F-5-Br CF_Three          H H C (O) CH₂Pr-c
3-F-5-Br CF_Three          H Et C (O) CH₂Pr-c
3-F-5-Br CF_Three          CH_Three        H C (O) CH₂Pr-c
3-F-5-Br CF_Three          H H C (O) CH₂CF_Three
3-F-5-Br CF_Three          CH_Three        H C (O) CH₂CF_Three
3-F-5-Br CF_Three          H H C (O) (E-6a)
3-F-5-Br CF_Three          CH_Three        H C (O) (E-6a)
3-F-5-Br CF_Three          H H C (O) NHEt
3-F-5-Br CF_Three          H H C (O) NHPr-c
3-F-5-Br CF_Three          CH_Three        H C (O) NHPr-c
3-F-5-Br CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-F-5-Br CF₂Cl H H C (O) Et
3-F-5-Br CF₂Cl H H C (O) Pr-n
3-F-5-Br CF₂Cl H H C (O) Pr-c
3-F-5-Br CF₂Cl H H C (O) CH₂Pr-c
3-F-5-Br CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-F-5-Br CF₂Cl H H C (O) CH₂CF_Three
3-F-5-Br CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-F-5-Br CF₂Cl H H C (O) (E-6a)
3-F-5-Br CF₂Cl CH_Three        H C (O) (E-6a)
3-F-5-Br CF₂Cl CH_Three        H C (O) NHPr-c
3-F-5-Br CF₂Br H H C (O) CH₂Pr-c
3-F-5-Br CF₂CHF₂      H H C (O) CH₂CF_Three
3-F-5-Br CF₂CF_Three       H H C (O) (E-6a)
3-Br-4-Cl CHF₂         H H C (O) Pr-n
3-Br-4-Cl CF_Three          H H C (O) Et
3-Br-4-Cl CF_Three          H H C (O) Pr-n
3-Br-4-Cl CF_Three          H H C (O) Pr-i
3-Br-4-Cl CF_Three          H H C (O) Pr-c
3-Br-4-Cl CF_Three          CH_Three        H C (O) Pr-c
3-Br-4-Cl CF_Three          H H C (O) Bu-i
3-Br-4-Cl CF_Three          H H C (O) CH₂Pr-c
3-Br-4-Cl CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Br-4-Cl CF_Three          H H C (O) CH₂CF_Three
3-Br-4-Cl CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Br-4-Cl CF_Three          H H C (O) (E-6a)
3-Br-4-Cl CF_Three          CH_Three        H C (O) (E-6a)
3-Br-4-Cl CF_Three          H H C (O) NHPr-c
3-Br-4-Cl CF_Three          CH_Three        H C (O) NHPr-c
3-Br-4-Cl CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Br-4-Cl CF₂Cl H H C (O) Pr-n
3-Br-4-Cl CF₂Cl H H C (O) Pr-c
3-Br-4-Cl CF₂Cl H H C (O) CH₂Pr-c
3-Br-4-Cl CF₂Cl H H C (O) CH₂CF_Three
3-Br-4-Cl CF₂Cl H H C (O) (E-6a)
3-Cl-4-Br CHF₂         H H C (O) Pr-c
3-Cl-4-Br CF_Three          H H C (O) Et
3-Cl-4-Br CF_Three          H H C (O) Pr-n
3-Cl-4-Br CF_Three          H H C (O) Pr-i
3-Cl-4-Br CF_Three          H H C (O) Pr-c
3-Cl-4-Br CF_Three          CH_Three        H C (O) Pr-c
3-Cl-4-Br CF_Three          H H C (O) Bu-i
3-Cl-4-Br CF_Three          H H C (O) CH₂Pr-c
3-Cl-4-Br CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Cl-4-Br CF_Three          H H C (O) CH₂CF_Three
3-Cl-4-Br CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Cl-4-Br CF_Three          H H C (O) (E-6a)
3-Cl-4-Br CF_Three          CH_Three        H C (O) (E-6a)
3-Cl-4-Br CF_Three          H H C (O) NHPr-c
3-Cl-4-Br CF_Three          CH_Three        H C (O) NHPr-c
3-Cl-4-Br CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Cl-4-Br CF₂Cl H H C (O) Pr-n
3-Cl-4-Br CF₂Cl H H C (O) Pr-c
3-Cl-4-Br CF₂Cl H H C (O) CH₂Pr-c
3-Cl-4-Br CF₂Cl H H C (O) CH₂CF_Three
3-Cl-4-Br CF₂Cl H H C (O) (E-6a)
3-Cl-5-Br CHF₂         H H C (O) Et
3-Cl-5-Br CHF₂         H H C (O) Pr-n
3-Cl-5-Br CHF₂         H H C (O) Pr-c
3-Cl-5-Br CHF₂         H H C (O) CH₂Pr-c
3-Cl-5-Br CHF₂         CH_Three        H C (O) CH₂Pr-c
3-Cl-5-Br CHF₂         H H C (O) CH₂CF_Three
3-Cl-5-Br CHF₂         CH_Three        H C (O) CH₂CF_Three
3-Cl-5-Br CHF₂         H H C (O) (E-6a)
3-Cl-5-Br CHF₂         CH_Three        H C (O) (E-6a)
3-Cl-5-Br CHF₂         CH_Three        H C (O) NHPr-c
3-Cl-5-Br CF_Three          H H H
3-Cl-5-Br CF_Three          CH_Three        H H
3-Cl-5-Br CF_Three          CN H H
3-Cl-5-Br CF_Three          H H C (O) CH_Three
3-Cl-5-Br CF_Three          H H C (O) Et
3-Cl-5-Br CF_Three          H Et C (O) Et
3-Cl-5-Br CF_Three          H CH₂Pr-c C (O) Et
3-Cl-5-Br CF_Three          H CH₂OCH_Three    C (O) Et
3-Cl-5-Br CF_Three          H CH₂CN C (O) Et
3-Cl-5-Br CF_Three          H CH₂CH = CH₂  C (O) Et
3-Cl-5-Br CF_Three          H CH₂C≡CH C (O) Et
3-Cl-5-Br CF_Three          CH_Three        H C (O) Et
3-Cl-5-Br CF_Three          CH_Three        Et C (O) Et
3-Cl-5-Br CF_Three          CH_Three        CH₂Pr-c C (O) Et
3-Cl-5-Br CF_Three          CH_Three        CH₂OCH_Three    C (O) Et
3-Cl-5-Br CF_Three          CH_Three        CH₂CN C (O) Et
3-Cl-5-Br CF_Three          CH_Three        CH₂C≡CH C (O) Et
3-Cl-5-Br CF_Three          H H C (O) Pr-n
3-Cl-5-Br CF_Three          H Et C (O) Pr-n
3-Cl-5-Br CF_Three          H CH₂Pr-c C (O) Pr-n
3-Cl-5-Br CF_Three          H CH₂OCH_Three    C (O) Pr-n
3-Cl-5-Br CF_Three          H CH₂CN C (O) Pr-n
3-Cl-5-Br CF_Three          H CH₂C≡CH C (O) Pr-n
3-Cl-5-Br CF_Three          CH_Three        H C (O) Pr-n
3-Cl-5-Br CF_Three          CF_Three        H C (O) Pr-n
3-Cl-5-Br CF_Three          CN H C (O) Pr-n
3-Cl-5-Br CF_Three          C≡CH H C (O) Pr-n
3-Cl-5-Br CF_Three          H H C (O) Pr-i
3-Cl-5-Br CF_Three          CH_Three        H C (O) Pr-i
3-Cl-5-Br CF_Three          H H C (O) Pr-c
3-Cl-5-Br CF_Three          H CH_Three        C (O) Pr-c
3-Cl-5-Br CF_Three          H Et C (O) Pr-c
3-Cl-5-Br CF_Three          H n-Pr C (O) Pr-c
3-Cl-5-Br CF_Three          H CH₂Pr-c C (O) Pr-c
3-Cl-5-Br CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-Cl-5-Br CF_Three          H CH₂CN C (O) Pr-c
3-Cl-5-Br CF_Three          H CH₂CH = CH₂  C (O) Pr-c
3-Cl-5-Br CF_Three          H CH₂C≡CH C (O) Pr-c
3-Cl-5-Br CF_Three          CH_Three        H C (O) Pr-c
3-Cl-5-Br CF_Three          CH_Three        Et C (O) Pr-c
3-Cl-5-Br CF_Three          CH_Three        CH₂Pr-c C (O) Pr-c
3-Cl-5-Br CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-c
3-Cl-5-Br CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-Cl-5-Br CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-Cl-5-Br CF_Three          CF_Three        H C (O) Pr-c
3-Cl-5-Br CF_Three          CN H C (O) Pr-c
3-Cl-5-Br CF_Three          C≡CH H C (O) Pr-c
3-Cl-5-Br CF_Three          H H C (O) Bu-i
3-Cl-5-Br CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-Br CF_Three          H Et C (O) CH₂Pr-c
3-Cl-5-Br CF_Three          H CH₂Pr-c C (O) CH₂Pr-c
3-Cl-5-Br CF_Three          H CH₂OCH_Three    C (O) CH₂Pr-c
3-Cl-5-Br CF_Three          H CH₂CN C (O) CH₂Pr-c
3-Cl-5-Br CF_Three          H CH₂CH = CH₂  C (O) CH₂Pr-c
3-Cl-5-Br CF_Three          H CH₂C≡CH C (O) CH₂Pr-c
3-Cl-5-Br CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Cl-5-Br CF_Three          CF_Three        H C (O) CH₂Pr-c
3-Cl-5-Br CF_Three          CN H C (O) CH₂Pr-c
3-Cl-5-Br CF_Three          C≡CH H C (O) CH₂Pr-c
3-Cl-5-Br CF_Three          H H C (O) (T-1)
3-Cl-5-Br CF_Three          CH_Three        H C (O) (T-1)
3-Cl-5-Br CF_Three          H H C (O) Bu-c
3-Cl-5-Br CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-Br CF_Three          H Et C (O) CH₂CF_Three
3-Cl-5-Br CF_Three          H CH₂Pr-c C (O) CH₂CF_Three
3-Cl-5-Br CF_Three          H CH₂OCH_Three    C (O) CH₂CF_Three
3-Cl-5-Br CF_Three          H CH₂CN C (O) CH₂CF_Three
3-Cl-5-Br CF_Three          H CH₂C≡CH C (O) CH₂CF_Three
3-Cl-5-Br CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Cl-5-Br CF_Three          CF_Three        H C (O) CH₂CF_Three
3-Cl-5-Br CF_Three          CN H C (O) CH₂CF_Three
3-Cl-5-Br CF_Three          C≡CH H C (O) CH₂CF_Three
3-Cl-5-Br CF_Three          H H C (O) CH₂CH₂CF_Three
3-Cl-5-Br CF_Three          H H C (O) (E-6a)
3-Cl-5-Br CF_Three          H Et C (O) (E-6a)
3-Cl-5-Br CF_Three          H CH₂Pr-c C (O) (E-6a)
3-Cl-5-Br CF_Three          H CH₂OCH_Three    C (O) (E-6a)
3-Cl-5-Br CF_Three          H CH₂CN C (O) (E-6a)
3-Cl-5-Br CF_Three          H CH₂C≡CH C (O) (E-6a)
3-Cl-5-Br CF_Three          CH_Three        H C (O) (E-6a)
3-Cl-5-Br CF_Three          CF_Three        H C (O) (E-6a)
3-Cl-5-Br CF_Three          CN H C (O) (E-6a)
3-Cl-5-Br CF_Three          C≡CH H C (O) (E-6a)
3-Cl-5-Br CF_Three          H H C (O) CH₂CH₂C≡CH
3-Cl-5-Br CF_Three          H H C (O) NHEt
3-Cl-5-Br CF_Three          H CH₂CH = CH₂  C (O) NHEt
3-Cl-5-Br CF_Three          H CH₂C≡CH C (O) NHEt
3-Cl-5-Br CF_Three          CH_Three        H C (O) NHEt
3-Cl-5-Br CF_Three          H H C (O) NHPr-c
3-Cl-5-Br CF_Three          CH_Three        H C (O) NHPr-c
3-Cl-5-Br CF_Three          H H C (O) NHCH₂CF_Three
3-Cl-5-Br CF_Three          CH_Three        H C (O) NHCH₂CF_Three
3-Cl-5-Br CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Cl-5-Br CF_Three          H H C (O) (T-23)
3-Cl-5-Br CF_Three          H H C (O) (T-33)
3-Cl-5-Br CF_Three          H H C (S) CH₂Pr-c
3-Cl-5-Br CF_Three          CH_Three        H C (S) CH₂Pr-c
3-Cl-5-Br CF₂Cl H H C (O) Et
3-Cl-5-Br CF₂Cl H H C (O) Pr-n
3-Cl-5-Br CF₂Cl H H C (O) Pr-i
3-Cl-5-Br CF₂Cl H H C (O) Pr-c
3-Cl-5-Br CF₂Cl CH_Three        H C (O) Pr-c
3-Cl-5-Br CF₂Cl H H C (O) Bu-i
3-Cl-5-Br CF₂Cl H H C (O) CH₂Pr-c
3-Cl-5-Br CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-Cl-5-Br CF₂Cl H H C (O) CH₂CF_Three
3-Cl-5-Br CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-Cl-5-Br CF₂Cl H H C (O) (E-6a)
3-Cl-5-Br CF₂Cl CH_Three        H C (O) (E-6a)
3-Cl-5-Br CF₂Cl H H C (O) NHPr-c
3-Cl-5-Br CF₂Cl CH_Three        H C (O) NHPr-c
3-Cl-5-Br CF₂Cl CH_Three        H C (O) NHCH₂C≡CH
3-Cl-5-Br CF₂Br H H C (O) Pr-n
3-Cl-5-Br CF₂Br H H C (O) Pr-c
3-Cl-5-Br CF₂Br H H C (O) CH₂Pr-c
3-Cl-5-Br CF₂Br H H C (O) CH₂CF_Three
3-Cl-5-Br CF₂Br H H C (O) (E-6a)
3-Cl-5-Br CF₂CHF₂      H H C (O) Pr-n
3-Cl-5-Br CF₂CHF₂      H H C (O) Pr-c
3-Cl-5-Br CF₂CHF₂      H H C (O) CH₂Pr-c
3-Cl-5-Br CF₂CHF₂      H H C (O) CH₂CF_Three
3-Cl-5-Br CF₂CHF₂      H H C (O) (E-6a)
3-Cl-5-Br CF₂CF_Three       H H C (O) Pr-n
3-Cl-5-Br CF₂CF_Three       H H C (O) Pr-c
3-Cl-5-Br CF₂CF_Three       H H C (O) CH₂Pr-c
3-Cl-5-Br CF₂CF_Three       H H C (O) CH₂CF_Three
3-Cl-5-Br CF₂CF_Three       H H C (O) (E-6a)
3,4-Br₂                CHF₂         H H C (O) CH₂Pr-c
3,4-Br₂                CF_Three          H H C (O) Et
3,4-Br₂                CF_Three          H H C (O) Pr-n
3,4-Br₂                CF_Three          H H C (O) Pr-i
3,4-Br₂                CF_Three          H H C (O) Pr-c
3,4-Br₂                CF_Three          CH_Three        H C (O) Pr-c
3,4-Br₂                CF_Three          H H C (O) Bu-i
3,4-Br₂                CF_Three          H H C (O) CH₂Pr-c
3,4-Br₂                CF_Three          CH_Three        H C (O) CH₂Pr-c
3,4-Br₂                CF_Three          H H C (O) CH₂CF_Three
3,4-Br₂                CF_Three          CH_Three        H C (O) CH₂CF_Three
3,4-Br₂                CF_Three          H H C (O) (E-6a)
3,4-Br₂                CF_Three          CH_Three        H C (O) (E-6a)
3,4-Br₂                CF_Three          H H C (O) NHPr-c
3,4-Br₂                CF_Three          CH_Three        H C (O) NHPr-c
3,4-Br₂                CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,4-Br₂                CF₂Cl H H C (O) Pr-n
3,4-Br₂                CF₂Cl H H C (O) Pr-c
3,4-Br₂                CF₂Cl H H C (O) CH₂Pr-c
3,4-Br₂                CF₂Cl H H C (O) CH₂CF_Three
3,4-Br₂                CF₂Cl H H C (O) (E-6a)
3,5-Br₂                CHF₂         H H C (O) Et
3,5-Br₂                CHF₂         H H C (O) Pr-n
3,5-Br₂                CHF₂         H H C (O) Pr-c
3,5-Br₂                CHF₂         H H C (O) CH₂Pr-c
3,5-Br₂                CHF₂         CH_Three        H C (O) CH₂Pr-c
3,5-Br₂                CHF₂         H H C (O) CH₂CF_Three
3,5-Br₂                CHF₂         CH_Three        H C (O) CH₂CF_Three
3,5-Br₂                CHF₂         H H C (O) (E-6a)
3,5-Br₂                CHF₂         CH_Three        H C (O) (E-6a)
3,5-Br₂                CHF₂         CH_Three        H C (O) NHPr-c
3,5-Br₂                CF_Three          H H H
3,5-Br₂                CF_Three          CH_Three        H H
3,5-Br₂                CF_Three          CN H H
3,5-Br₂                CF_Three          H H C (O) CH_Three
3,5-Br₂                CF_Three          H H C (O) Et
3,5-Br₂                CF_Three          H Et C (O) Et
3,5-Br₂                CF_Three          H CH₂Pr-c C (O) Et
3,5-Br₂                CF_Three          H CH₂OCH_Three    C (O) Et
3,5-Br₂                CF_Three          H CH₂CN C (O) Et
3,5-Br₂                CF_Three          H CH₂CH = CH₂  C (O) Et
3,5-Br₂                CF_Three          H CH₂C≡CH C (O) Et
3,5-Br₂                CF_Three          CH_Three        H C (O) Et
3,5-Br₂                CF_Three          CH_Three        Et C (O) Et
3,5-Br₂                CF_Three          CH_Three        CH₂Pr-c C (O) Et
3,5-Br₂                CF_Three          CH_Three        CH₂OCH_Three    C (O) Et
3,5-Br₂                CF_Three          CH_Three        CH₂CN C (O) Et
3,5-Br₂                CF_Three          CH_Three        CH₂C≡CH C (O) Et
3,5-Br₂                CF_Three          H H C (O) Pr-n
3,5-Br₂                CF_Three          H Et C (O) Pr-n
3,5-Br₂                CF_Three          H CH₂Pr-c C (O) Pr-n
3,5-Br₂                CF_Three          H CH₂OCH_Three    C (O) Pr-n
3,5-Br₂                CF_Three          H CH₂CN C (O) Pr-n
3,5-Br₂                CF_Three          H CH₂C≡CH C (O) Pr-n
3,5-Br₂                CF_Three          CH_Three        H C (O) Pr-n
3,5-Br₂                CF_Three          CF_Three        H C (O) Pr-n
3,5-Br₂                CF_Three          CN H C (O) Pr-n
3,5-Br₂                CF_Three          C≡CH H C (O) Pr-n
3,5-Br₂                CF_Three          H H C (O) Pr-i
3,5-Br₂                CF_Three          CH_Three        H C (O) Pr-i
3,5-Br₂                CF_Three          H H C (O) Pr-c
3,5-Br₂                CF_Three          H CH_Three        C (O) Pr-c
3,5-Br₂                CF_Three          H Et C (O) Pr-c
3,5-Br₂                CF_Three          H n-Pr C (O) Pr-c
3,5-Br₂                CF_Three          H CH₂Pr-c C (O) Pr-c
3,5-Br₂                CF_Three          H CH₂OCH_Three    C (O) Pr-c
3,5-Br₂                CF_Three          H CH₂CN C (O) Pr-c
3,5-Br₂                CF_Three          H CH₂CH = CH₂  C (O) Pr-c
3,5-Br₂                CF_Three          H CH₂C≡CH C (O) Pr-c
3,5-Br₂                CF_Three          CH_Three        H C (O) Pr-c
3,5-Br₂                CF_Three          CH_Three        Et C (O) Pr-c
3,5-Br₂                CF_Three          CH_Three        CH₂Pr-c C (O) Pr-c
3,5-Br₂                CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-c
3,5-Br₂                CF_Three          CH_Three        CH₂CN C (O) Pr-c
3,5-Br₂                CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3,5-Br₂                CF_Three          CF_Three        H C (O) Pr-c
3,5-Br₂                CF_Three          CN H C (O) Pr-c
3,5-Br₂                CF_Three          C≡CH H C (O) Pr-c
3,5-Br₂                CF_Three          H H C (O) Bu-i
3,5-Br₂                CF_Three          H H C (O) CH₂Pr-c
3,5-Br₂                CF_Three          H Et C (O) CH₂Pr-c
3,5-Br₂                CF_Three          H CH₂Pr-c C (O) CH₂Pr-c
3,5-Br₂                CF_Three          H CH₂OCH_Three    C (O) CH₂Pr-c
3,5-Br₂                CF_Three          H CH₂CN C (O) CH₂Pr-c
3,5-Br₂                CF_Three          H CH₂CH = CH₂  C (O) CH₂Pr-c
3,5-Br₂                CF_Three          H CH₂C≡CH C (O) CH₂Pr-c
3,5-Br₂                CF_Three          CH_Three        H C (O) CH₂Pr-c
3,5-Br₂                CF_Three          CF_Three        H C (O) CH₂Pr-c
3,5-Br₂                CF_Three          CN H C (O) CH₂Pr-c
3,5-Br₂                CF_Three          C≡CH H C (O) CH₂Pr-c
3,5-Br₂                CF_Three          H H C (O) (T-1)
3,5-Br₂                CF_Three          CH_Three        H C (O) (T-1)
3,5-Br₂                CF_Three          H H C (O) Bu-c
3,5-Br₂                CF_Three          H H C (O) CH₂CF_Three
3,5-Br₂                CF_Three          H Et C (O) CH₂CF_Three
3,5-Br₂                CF_Three          H CH₂Pr-c C (O) CH₂CF_Three
3,5-Br₂                CF_Three          H CH₂OCH_Three    C (O) CH₂CF_Three
3,5-Br₂                CF_Three          H CH₂CN C (O) CH₂CF_Three
3,5-Br₂                CF_Three          H CH₂C≡CH C (O) CH₂CF_Three
3,5-Br₂                CF_Three          CH_Three        H C (O) CH₂CF_Three
3,5-Br₂                CF_Three          CF_Three        H C (O) CH₂CF_Three
3,5-Br₂                CF_Three          CN H C (O) CH₂CF_Three
3,5-Br₂                CF_Three          C≡CH H C (O) CH₂CF_Three
3,5-Br₂                CF_Three          H H C (O) CH₂CH₂CF_Three
3,5-Br₂                CF_Three          H H C (O) (E-6a)
3,5-Br₂                CF_Three          H Et C (O) (E-6a)
3,5-Br₂                CF_Three          H CH₂Pr-c C (O) (E-6a)
3,5-Br₂                CF_Three          H CH₂OCH_Three    C (O) (E-6a)
3,5-Br₂                CF_Three          H CH₂CN C (O) (E-6a)
3,5-Br₂                CF_Three          H CH₂C≡CH C (O) (E-6a)
3,5-Br₂                CF_Three          CH_Three        H C (O) (E-6a)
3,5-Br₂                CF_Three          CF_Three        H C (O) (E-6a)
3,5-Br₂                CF_Three          CN H C (O) (E-6a)
3,5-Br₂                CF_Three          C≡CH H C (O) (E-6a)
3,5-Br₂                CF_Three          H H C (O) CH₂CH₂C≡CH
3,5-Br₂                CF_Three          H H C (O) NHEt
3,5-Br₂                CF_Three          H CH₂CH = CH₂  C (O) NHEt
3,5-Br₂                CF_Three          H CH₂C≡CH C (O) NHEt
3,5-Br₂                CF_Three          CH_Three        H C (O) NHEt
3,5-Br₂                CF_Three          H H C (O) NHPr-c
3,5-Br₂                CF_Three          CH_Three        H C (O) NHPr-c
3,5-Br₂                CF_Three          H H C (O) NHCH₂CF_Three
3,5-Br₂                CF_Three          CH_Three        H C (O) NHCH₂CF_Three
3,5-Br₂                CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,5-Br₂                CF_Three          H H C (O) (T-23)
3,5-Br₂                CF_Three          H H C (O) (T-33)
3,5-Br₂                CF_Three          H H C (S) CH₂Pr-c
3,5-Br₂                CF_Three          CH_Three        H C (S) CH₂Pr-c
3,5-Br₂                CF₂Cl H H C (O) Et
3,5-Br₂                CF₂Cl H H C (O) Pr-n
3,5-Br₂                CF₂Cl H H C (O) Pr-i
3,5-Br₂                CF₂Cl H H C (O) Pr-c
3,5-Br₂                CF₂Cl CH_Three        H C (O) Pr-c
3,5-Br₂                CF₂Cl H H C (O) Bu-i
3,5-Br₂                CF₂Cl H H C (O) CH₂Pr-c
3,5-Br₂                CF₂Cl CH_Three        H C (O) CH₂Pr-c
3,5-Br₂                CF₂Cl H H C (O) CH₂CF_Three
3,5-Br₂                CF₂Cl CH_Three        H C (O) CH₂CF_Three
3,5-Br₂                CF₂Cl H H C (O) (E-6a)
3,5-Br₂                CF₂Cl CH_Three        H C (O) (E-6a)
3,5-Br₂                CF₂Cl H H C (O) NHPr-c
3,5-Br₂                CF₂Cl CH_Three        H C (O) NHPr-c
3,5-Br₂                CF₂Cl CH_Three        H C (O) NHCH₂C≡CH
3,5-Br₂                CF₂Br H H C (O) Pr-n
3,5-Br₂                CF₂Br H H C (O) Pr-c
3,5-Br₂                CF₂Br H H C (O) CH₂Pr-c
3,5-Br₂                CF₂Br H H C (O) CH₂CF_Three
3,5-Br₂                CF₂Br H H C (O) (E-6a)
3,5-Br₂                CF₂CHF₂      H H C (O) Pr-n
3,5-Br₂                CF₂CHF₂      H H C (O) Pr-c
3,5-Br₂                CF₂CHF₂      H H C (O) CH₂Pr-c
3,5-Br₂                CF₂CHF₂      H H C (O) CH₂CF_Three
3,5-Br₂                CF₂CHF₂      H H C (O) (E-6a)
3,5-Br₂                CF₂CF_Three       H H C (O) Pr-n
3,5-Br₂                CF₂CF_Three       H H C (O) Pr-c
3,5-Br₂                CF₂CF_Three       H H C (O) CH₂Pr-c
3,5-Br₂                CF₂CF_Three       H H C (O) CH₂CF_Three
3,5-Br₂                CF₂CF_Three       H H C (O) (E-6a)
3-I-4-F CHF₂         H H C (O) CH₂CF_Three
3-I-4-F CF_Three          H H C (O) Et
3-I-4-F CF_Three          H H C (O) Pr-n
3-I-4-F CF_Three          H H C (O) Pr-i
3-I-4-F CF_Three          H H C (O) Pr-c
3-I-4-F CF_Three          CH_Three        H C (O) Pr-c
3-I-4-F CF_Three          H H C (O) Bu-i
3-I-4-F CF_Three          H H C (O) CH₂Pr-c
3-I-4-F CF_Three          CH_Three        H C (O) CH₂Pr-c
3-I-4-F CF_Three          H H C (O) CH₂CF_Three
3-I-4-F CF_Three          CH_Three        H C (O) CH₂CF_Three
3-I-4-F CF_Three          H H C (O) (E-6a)
3-I-4-F CF_Three          CH_Three        H C (O) (E-6a)
3-I-4-F CF_Three          H H C (O) NHPr-c
3-I-4-F CF_Three          CH_Three        H C (O) NHPr-c
3-I-4-F CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-I-4-F CF₂Cl H H C (O) Pr-n
3-I-4-F CF₂Cl H H C (O) Pr-c
3-I-4-F CF₂Cl H H C (O) CH₂Pr-c
3-I-4-F CF₂Cl H H C (O) CH₂CF_Three
3-I-4-F CF₂Cl H H C (O) (E-6a)
3-F-5-I CHF₂         H H C (O) (E-6a)
3-F-5-I CF_Three          H H C (O) Et
3-F-5-I CF_Three          H H C (O) Pr-n
3-F-5-I CF_Three          H H C (O) Pr-i
3-F-5-I CF_Three          H H C (O) Pr-c
3-F-5-I CF_Three          CH_Three        H C (O) Pr-c
3-F-5-I CF_Three          H H C (O) Bu-i
3-F-5-I CF_Three          H H C (O) CH₂Pr-c
3-F-5-I CF_Three          CH_Three        H C (O) CH₂Pr-c
3-F-5-I CF_Three          H H C (O) CH₂CF_Three
3-F-5-I CF_Three          CH_Three        H C (O) CH₂CF_Three
3-F-5-I CF_Three          H H C (O) (E-6a)
3-F-5-I CF_Three          CH_Three        H C (O) (E-6a)
3-F-5-I CF_Three          H H C (O) NHPr-c
3-F-5-I CF_Three          CH_Three        H C (O) NHPr-c
3-F-5-I CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-F-5-I CF₂Cl H H C (O) Pr-n
3-F-5-I CF₂Cl H H C (O) Pr-c
3-F-5-I CF₂Cl H H C (O) CH₂Pr-c
3-F-5-I CF₂Cl H H C (O) CH₂CF_Three
3-F-5-I CF₂Cl H H C (O) (E-6a)
3-Cl-5-I CHF₂         H H C (O) Pr-n
3-Cl-5-I CHF₂         H H C (O) Pr-c
3-Cl-5-I CHF₂         H H C (O) CH₂Pr-c
3-Cl-5-I CHF₂         H H C (O) CH₂CF_Three
3-Cl-5-I CHF₂         H H C (O) (E-6a)
3-Cl-5-I CF_Three          H H C (O) Et
3-Cl-5-I CF_Three          H Et C (O) Et
3-Cl-5-I CF_Three          H CH₂C≡CH C (O) Et
3-Cl-5-I CF_Three          CH_Three        H C (O) Et
3-Cl-5-I CF_Three          H H C (O) Pr-n
3-Cl-5-I CF_Three          H Et C (O) Pr-n
3-Cl-5-I CF_Three          CH_Three        H C (O) Pr-n
3-Cl-5-I CF_Three          H H C (O) Pr-i
3-Cl-5-I CF_Three          CH_Three        H C (O) Pr-i
3-Cl-5-I CF_Three          H H C (O) Pr-c
3-Cl-5-I CF_Three          H Et C (O) Pr-c
3-Cl-5-I CF_Three          H CH₂Pr-c C (O) Pr-c
3-Cl-5-I CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-Cl-5-I CF_Three          H CH₂C≡CH C (O) Pr-c
3-Cl-5-I CF_Three          CH_Three        H C (O) Pr-c
3-Cl-5-I CF_Three          CH_Three        Et C (O) Pr-c
3-Cl-5-I CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-Cl-5-I CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-Cl-5-I CF_Three          H H C (O) Bu-i
3-Cl-5-I CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-I CF_Three          H Et C (O) CH₂Pr-c
3-Cl-5-I CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Cl-5-I CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-I CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Cl-5-I CF_Three          H H C (O) (E-6a)
3-Cl-5-I CF_Three          CH_Three        H C (O) (E-6a)
3-Cl-5-I CF_Three          H H C (O) NHEt
3-Cl-5-I CF_Three          H H C (O) NHPr-c
3-Cl-5-I CF_Three          CH_Three        H C (O) NHPr-c
3-Cl-5-I CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Cl-5-I CF₂Cl H H C (O) Et
3-Cl-5-I CF₂Cl H H C (O) Pr-n
3-Cl-5-I CF₂Cl H H C (O) Pr-c
3-Cl-5-I CF₂Cl H H C (O) CH₂Pr-c
3-Cl-5-I CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-Cl-5-I CF₂Cl H H C (O) CH₂CF_Three
3-Cl-5-I CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-Cl-5-I CF₂Cl H H C (O) (E-6a)
3-Cl-5-I CF₂Cl CH_Three        H C (O) (E-6a)
3-Cl-5-I CF₂Cl CH_Three        H C (O) NHPr-c
3-Cl-5-I CF₂Br H H C (O) Pr-n
3-Cl-5-I CF₂CHF₂      H H C (O) Pr-c
3-Cl-5-I CF₂CF_Three       H H C (O) CH₂Pr-c
3,5-I₂                 CF_Three          H H C (O) Pr-n
3,5-I₂                 CF_Three          H H C (O) Pr-c
3,5-I₂                 CF_Three          H H C (O) CH₂Pr-c
3,5-I₂                 CF_Three          H H C (O) CH₂CF_Three
3,5-I₂                 CF_Three          H H C (O) (E-6a)
3-CH_Three-4-F CF_Three          H H C (O) Pr-n
3-CH_Three-4-F CF_Three          H H C (O) Pr-c
3-CH_Three-4-F CF_Three          H H C (O) CH₂Pr-c
3-CH_Three-4-F CF_Three          H H C (O) CH₂CF_Three
3-CH_Three-4-F CF_Three          H H C (O) (E-6a)
3-F-5-CH_Three              CF_Three          H H C (O) CH₂CF_Three
3-Cl-4-CH_Three             CF_Three          H H C (O) Pr-n
3-Cl-4-CH_Three             CF_Three          H H C (O) Pr-c
3-Cl-4-CH_Three             CF_Three          H H C (O) CH₂Pr-c
3-Cl-4-CH_Three             CF_Three          H H C (O) CH₂CF_Three
3-Cl-4-CH_Three             CF_Three          H H C (O) (E-6a)
3-Cl-5-CH_Three             CF_Three          H H C (O) Et
3-Cl-5-CH_Three             CF_Three          H H C (O) Pr-n
3-Cl-5-CH_Three             CF_Three          H H C (O) Pr-c
3-Cl-5-CH_Three             CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-CH_Three             CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Cl-5-CH_Three             CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-CH_Three             CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Cl-5-CH_Three             CF_Three          H H C (O) (E-6a)
3-Cl-5-CH_Three             CF_Three          CH_Three        H C (O) (E-6a)
3-Cl-5-CH_Three             CF_Three          CH_Three        H C (O) NHPr-c
3-Cl-5-CH_Three             CF₂Cl H H C (O) (E-6a)
3-Br-4-CH_Three             CF_Three          H H C (O) Pr-n
3-Br-4-CH_Three             CF_Three          H H C (O) Pr-c
3-Br-4-CH_Three             CF_Three          H H C (O) CH₂Pr-c
3-Br-4-CH_Three             CF_Three          H H C (O) CH₂CF_Three
3-Br-4-CH_Three             CF_Three          H H C (O) (E-6a)
3-Br-5-CH_Three             CF_Three          H H C (O) Et
3-Br-5-CH_Three             CF_Three          H H C (O) Pr-n
3-Br-5-CH_Three             CF_Three          H H C (O) Pr-c
3-Br-5-CH_Three             CF_Three          H H C (O) CH₂Pr-c
3-Br-5-CH_Three             CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Br-5-CH_Three             CF_Three          H H C (O) CH₂CF_Three
3-Br-5-CH_Three             CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Br-5-CH_Three             CF_Three          H H C (O) (E-6a)
3-Br-5-CH_Three             CF_Three          CH_Three        H C (O) (E-6a)
3-Br-5-CH_Three             CF_Three          CH_Three        H C (O) NHPr-c
3-Br-5-CH_Three             CF₂Cl H H C (O) Pr-n
3-Br-5-Et CF_Three          H H C (O) Pr-c
3-Cl-5-Pr-i CF_Three          H H C (O) CH₂Pr-c
3-Br-5-Pr-i CF_Three          H H C (O) CH₂CF_Three
3,5- (CH_Three)₂             CF_Three          H H C (O) Pr-n
3,5- (CH_Three)₂             CF_Three          H H C (O) Pr-c
3,5- (CH_Three)₂             CF_Three          H H C (O) CH₂Pr-c
3,5- (CH_Three)₂             CF_Three          H H C (O) CH₂CF_Three
3,5- (CH_Three)₂             CF_Three          H H C (O) (E-6a)
3-CF_Three-4-F CHF₂         H H C (O) Pr-n
3-CF_Three-4-F CHF₂         H H C (O) Pr-c
3-CF_Three-4-F CHF₂         H H C (O) CH₂Pr-c
3-CF_Three-4-F CHF₂         H H C (O) CH₂CF_Three
3-CF_Three-4-F CHF₂         H H C (O) (E-6a)
3-CF_Three-4-F CF_Three          H H C (O) Et
3-CF_Three-4-F CF_Three          H Et C (O) Et
3-CF_Three-4-F CF_Three          H CH₂C≡CH C (O) Et
3-CF_Three-4-F CF_Three          CH_Three        H C (O) Et
3-CF_Three-4-F CF_Three          H H C (O) Pr-n
3-CF_Three-4-F CF_Three          H Et C (O) Pr-n
3-CF_Three-4-F CF_Three          CH_Three        H C (O) Pr-n
3-CF_Three-4-F CF_Three          H H C (O) Pr-i
3-CF_Three-4-F CF_Three          CH_Three        H C (O) Pr-i
3-CF_Three-4-F CF_Three          H H C (O) Pr-c
3-CF_Three-4-F CF_Three          H Et C (O) Pr-c
3-CF_Three-4-F CF_Three          H CH₂Pr-c C (O) Pr-c
3-CF_Three-4-F CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-CF_Three-4-F CF_Three          H CH₂C≡CH C (O) Pr-c
3-CF_Three-4-F CF_Three          CH_Three        H C (O) Pr-c
3-CF_Three-4-F CF_Three          CH_Three        Et C (O) Pr-c
3-CF_Three-4-F CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-CF_Three-4-F CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-CF_Three-4-F CF_Three          H H C (O) Bu-i
3-CF_Three-4-F CF_Three          H H C (O) CH₂Pr-c
3-CF_Three-4-F CF_Three          H Et C (O) CH₂Pr-c
3-CF_Three-4-F CF_Three          CH_Three        H C (O) CH₂Pr-c
3-CF_Three-4-F CF_Three          H H C (O) CH₂CF_Three
3-CF_Three-4-F CF_Three          CH_Three        H C (O) CH₂CF_Three
3-CF_Three-4-F CF_Three          H H C (O) (E-6a)
3-CF_Three-4-F CF_Three          CH_Three        H C (O) (E-6a)
3-CF_Three-4-F CF_Three          H H C (O) NHEt
3-CF_Three-4-F CF_Three          H H C (O) NHPr-c
3-CF_Three-4-F CF_Three          CH_Three        H C (O) NHPr-c
3-CF_Three-4-F CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-CF_Three-4-F CF₂Cl H H C (O) Et
3-CF_Three-4-F CF₂Cl H H C (O) Pr-n
3-CF_Three-4-F CF₂Cl H H C (O) Pr-c
3-CF_Three-4-F CF₂Cl H H C (O) CH₂Pr-c
3-CF_Three-4-F CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-CF_Three-4-F CF₂Cl H H C (O) CH₂CF_Three
3-CF_Three-4-F CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-CF_Three-4-F CF₂Cl H H C (O) (E-6a)
3-CF_Three-4-F CF₂Cl CH_Three        H C (O) (E-6a)
3-CF_Three-4-F CF₂Cl CH_Three        H C (O) NHPr-c
3-CF_Three-4-F CF₂Br H H C (O) (E-6a)
3-CF_Three-4-F CF₂CHF₂      H H C (O) Pr-n
3-CF_Three-4-F CF₂CF_Three       H H C (O) Pr-c
3-F-5-CF_Three              CHF₂         H H C (O) Pr-n
3-F-5-CF_Three              CHF₂         H H C (O) Pr-c
3-F-5-CF_Three              CHF₂         H H C (O) CH₂Pr-c
3-F-5-CF_Three              CHF₂         H H C (O) CH₂CF_Three
3-F-5-CF_Three              CHF₂         H H C (O) (E-6a)
3-F-5-CF_Three              CF_Three          H H C (O) Et
3-F-5-CF_Three              CF_Three          H Et C (O) Et
3-F-5-CF_Three              CF_Three          H CH₂C≡CH C (O) Et
3-F-5-CF_Three              CF_Three          CH_Three        H C (O) Et
3-F-5-CF_Three              CF_Three          H H C (O) Pr-n
3-F-5-CF_Three              CF_Three          H Et C (O) Pr-n
3-F-5-CF_Three              CF_Three          CH_Three        H C (O) Pr-n
3-F-5-CF_Three              CF_Three          H H C (O) Pr-i
3-F-5-CF_Three              CF_Three          CH_Three        H C (O) Pr-i
3-F-5-CF_Three              CF_Three          H H C (O) Pr-c
3-F-5-CF_Three              CF_Three          H Et C (O) Pr-c
3-F-5-CF_Three              CF_Three          H CH₂Pr-c C (O) Pr-c
3-F-5-CF_Three              CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-F-5-CF_Three              CF_Three          H CH₂C≡CH C (O) Pr-c
3-F-5-CF_Three              CF_Three          CH_Three        H C (O) Pr-c
3-F-5-CF_Three              CF_Three          CH_Three        Et C (O) Pr-c
3-F-5-CF_Three              CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-F-5-CF_Three              CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-F-5-CF_Three              CF_Three          H H C (O) Bu-i
3-F-5-CF_Three              CF_Three          H H C (O) CH₂Pr-c
3-F-5-CF_Three              CF_Three          H Et C (O) CH₂Pr-c
3-F-5-CF_Three              CF_Three          CH_Three        H C (O) CH₂Pr-c
3-F-5-CF_Three              CF_Three          H H C (O) CH₂CF_Three
3-F-5-CF_Three              CF_Three          CH_Three        H C (O) CH₂CF_Three
3-F-5-CF_Three              CF_Three          H H C (O) (E-6a)
3-F-5-CF_Three              CF_Three          CH_Three        H C (O) (E-6a)
3-F-5-CF_Three              CF_Three          H H C (O) NHEt
3-F-5-CF_Three              CF_Three          H H C (O) NHPr-c
3-F-5-CF_Three              CF_Three          CH_Three        H C (O) NHPr-c
3-F-5-CF_Three              CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-F-5-CF_Three              CF₂Cl H H C (O) Et
3-F-5-CF_Three              CF₂Cl H H C (O) Pr-n
3-F-5-CF_Three              CF₂Cl H H C (O) Pr-c
3-F-5-CF_Three              CF₂Cl H H C (O) CH₂Pr-c
3-F-5-CF_Three              CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-F-5-CF_Three              CF₂Cl H H C (O) CH₂CF_Three
3-F-5-CF_Three              CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-F-5-CF_Three              CF₂Cl H H C (O) (E-6a)
3-F-5-CF_Three              CF₂Cl CH_Three        H C (O) (E-6a)
3-F-5-CF_Three              CF₂Cl CH_Three        H C (O) NHPr-c
3-F-5-CF_Three              CF₂Br H H C (O) CH₂Pr-c
3-F-5-CF_Three              CF₂CHF₂      H H C (O) CH₂CF_Three
3-F-5-CF_Three              CF₂CF_Three       H H C (O) (E-6a)
3-CF_Three-4-Cl CHF₂         H H C (O) Pr-n
3-CF_Three-4-Cl CHF₂         H H C (O) Pr-c
3-CF_Three-4-Cl CHF₂         H H C (O) CH₂Pr-c
3-CF_Three-4-Cl CHF₂         H H C (O) CH₂CF_Three
3-CF_Three-4-Cl CHF₂         H H C (O) (E-6a)
3-CF_Three-4-Cl CF_Three          H H C (O) Et
3-CF_Three-4-Cl CF_Three          H Et C (O) Et
3-CF_Three-4-Cl CF_Three          H CH₂C≡CH C (O) Et
3-CF_Three-4-Cl CF_Three          CH_Three        H C (O) Et
3-CF_Three-4-Cl CF_Three          H H C (O) Pr-n
3-CF_Three-4-Cl CF_Three          H Et C (O) Pr-n
3-CF_Three-4-Cl CF_Three          CH_Three        H C (O) Pr-n
3-CF_Three-4-Cl CF_Three          H H C (O) Pr-i
3-CF_Three-4-Cl CF_Three          CH_Three        H C (O) Pr-i
3-CF_Three-4-Cl CF_Three          H H C (O) Pr-c
3-CF_Three-4-Cl CF_Three          H Et C (O) Pr-c
3-CF_Three-4-Cl CF_Three          H CH₂Pr-c C (O) Pr-c
3-CF_Three-4-Cl CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-CF_Three-4-Cl CF_Three          H CH₂C≡CH C (O) Pr-c
3-CF_Three-4-Cl CF_Three          CH_Three        H C (O) Pr-c
3-CF_Three-4-Cl CF_Three          CH_Three        Et C (O) Pr-c
3-CF_Three-4-Cl CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-CF_Three-4-Cl CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-CF_Three-4-Cl CF_Three          H H C (O) Bu-i
3-CF_Three-4-Cl CF_Three          H H C (O) CH₂Pr-c
3-CF_Three-4-Cl CF_Three          H Et C (O) CH₂Pr-c
3-CF_Three-4-Cl CF_Three          CH_Three        H C (O) CH₂Pr-c
3-CF_Three-4-Cl CF_Three          H H C (O) CH₂CF_Three
3-CF_Three-4-Cl CF_Three          CH_Three        H C (O) CH₂CF_Three
3-CF_Three-4-Cl CF_Three          H H C (O) (E-6a)
3-CF_Three-4-Cl CF_Three          CH_Three        H C (O) (E-6a)
3-CF_Three-4-Cl CF_Three          H H C (O) NHEt
3-CF_Three-4-Cl CF_Three          H H C (O) NHPr-c
3-CF_Three-4-Cl CF_Three          CH_Three        H C (O) NHPr-c
3-CF_Three-4-Cl CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-CF_Three-4-Cl CF₂Cl H H C (O) Et
3-CF_Three-4-Cl CF₂Cl H H C (O) Pr-n
3-CF_Three-4-Cl CF₂Cl H H C (O) Pr-c
3-CF_Three-4-Cl CF₂Cl H H C (O) CH₂Pr-c
3-CF_Three-4-Cl CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-CF_Three-4-Cl CF₂Cl H H C (O) CH₂CF_Three
3-CF_Three-4-Cl CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-CF_Three-4-Cl CF₂Cl H H C (O) (E-6a)
3-CF_Three-4-Cl CF₂Cl CH_Three        H C (O) (E-6a)
3-CF_Three-4-Cl CF₂Cl CH_Three        H C (O) NHPr-c
3-CF_Three-4-Cl CF₂Br H H C (O) Pr-n
3-CF_Three-4-Cl CF₂CHF₂      H H C (O) Pr-c
3-CF_Three-4-Cl CF₂CF_Three       H H C (O) CH₂Pr-c
3-Cl-5-CF_Three             CHF₂         H H C (O) Et
3-Cl-5-CF_Three             CHF₂         H H C (O) Pr-n
3-Cl-5-CF_Three             CHF₂         H H C (O) Pr-c
3-Cl-5-CF_Three             CHF₂         H H C (O) CH₂Pr-c
3-Cl-5-CF_Three             CHF₂         CH_Three        H C (O) CH₂Pr-c
3-Cl-5-CF_Three             CHF₂         H H C (O) CH₂CF_Three
3-Cl-5-CF_Three             CHF₂         CH_Three        H C (O) CH₂CF_Three
3-Cl-5-CF_Three             CHF₂         H H C (O) (E-6a)
3-Cl-5-CF_Three             CHF₂         CH_Three        H C (O) (E-6a)
3-Cl-5-CF_Three             CHF₂         CH_Three        H C (O) NHPr-c
3-Cl-5-CF_Three             CF_Three          H H H
3-Cl-5-CF_Three             CF_Three          CH_Three        H H
3-Cl-5-CF_Three             CF_Three          CN H H
3-Cl-5-CF_Three             CF_Three          H H C (O) CH_Three
3-Cl-5-CF_Three             CF_Three          H H C (O) Et
3-Cl-5-CF_Three             CF_Three          H Et C (O) Et
3-Cl-5-CF_Three             CF_Three          H CH₂Pr-c C (O) Et
3-Cl-5-CF_Three             CF_Three          H CH₂OCH_Three    C (O) Et
3-Cl-5-CF_Three             CF_Three          H CH₂CN C (O) Et
3-Cl-5-CF_Three             CF_Three          H CH₂CH = CH₂  C (O) Et
3-Cl-5-CF_Three             CF_Three          H CH₂C≡CH C (O) Et
3-Cl-5-CF_Three             CF_Three          CH_Three        H C (O) Et
3-Cl-5-CF_Three             CF_Three          CH_Three        Et C (O) Et
3-Cl-5-CF_Three             CF_Three          CH_Three        CH₂Pr-c C (O) Et
3-Cl-5-CF_Three             CF_Three          CH_Three        CH₂OCH_Three    C (O) Et
3-Cl-5-CF_Three             CF_Three          CH_Three        CH₂CN C (O) Et
3-Cl-5-CF_Three             CF_Three          CH_Three        CH₂C≡CH C (O) Et
3-Cl-5-CF_Three             CF_Three          H H C (O) Pr-n
3-Cl-5-CF_Three             CF_Three          H Et C (O) Pr-n
3-Cl-5-CF_Three             CF_Three          H CH₂Pr-c C (O) Pr-n
3-Cl-5-CF_Three             CF_Three          H CH₂OCH_Three    C (O) Pr-n
3-Cl-5-CF_Three             CF_Three          H CH₂CN C (O) Pr-n
3-Cl-5-CF_Three             CF_Three          H CH₂C≡CH C (O) Pr-n
3-Cl-5-CF_Three             CF_Three          CH_Three        H C (O) Pr-n
3-Cl-5-CF_Three             CF_Three          CF_Three        H C (O) Pr-n
3-Cl-5-CF_Three             CF_Three          CN H C (O) Pr-n
3-Cl-5-CF_Three             CF_Three          C≡CH H C (O) Pr-n
3-Cl-5-CF_Three             CF_Three          H H C (O) Pr-i
3-Cl-5-CF_Three             CF_Three          CH_Three        H C (O) Pr-i
3-Cl-5-CF_Three             CF_Three          H H C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          H CH_Three        C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          H Et C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          H n-Pr C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          H CH₂Pr-c C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          H CH₂CN C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          H CH₂CH = CH₂  C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          H CH₂C≡CH C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          CH_Three        H C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          CH_Three        Et C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          CH_Three        CH₂Pr-c C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          CF_Three        H C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          CN H C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          C≡CH H C (O) Pr-c
3-Cl-5-CF_Three             CF_Three          H H C (O) Bu-i
3-Cl-5-CF_Three             CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF_Three          H Et C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF_Three          H CH₂Pr-c C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF_Three          H CH₂OCH_Three    C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF_Three          H CH₂CN C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF_Three          H CH₂CH = CH₂  C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF_Three          H CH₂C≡CH C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF_Three          CF_Three        H C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF_Three          CN H C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF_Three          C≡CH H C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF_Three          H H C (O) (T-1)
3-Cl-5-CF_Three             CF_Three          CH_Three        H C (O) (T-1)
3-Cl-5-CF_Three             CF_Three          H H C (O) Bu-c
3-Cl-5-CF_Three             CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF_Three          H Et C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF_Three          H CH₂Pr-c C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF_Three          H CH₂OCH_Three    C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF_Three          H CH₂CN C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF_Three          H CH₂C≡CH C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF_Three          CF_Three        H C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF_Three          CN H C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF_Three          C≡CH H C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF_Three          H H C (O) CH₂CH₂CF_Three
3-Cl-5-CF_Three             CF_Three          H H C (O) (E-6a)
3-Cl-5-CF_Three             CF_Three          H Et C (O) (E-6a)
3-Cl-5-CF_Three             CF_Three          H CH₂Pr-c C (O) (E-6a)
3-Cl-5-CF_Three             CF_Three          H CH₂OCH_Three    C (O) (E-6a)
3-Cl-5-CF_Three             CF_Three          H CH₂CN C (O) (E-6a)
3-Cl-5-CF_Three             CF_Three          H CH₂C≡CH C (O) (E-6a)
3-Cl-5-CF_Three             CF_Three          CH_Three        H C (O) (E-6a)
3-Cl-5-CF_Three             CF_Three          CF_Three        H C (O) (E-6a)
3-Cl-5-CF_Three             CF_Three          CN H C (O) (E-6a)
3-Cl-5-CF_Three             CF_Three          C≡CH H C (O) (E-6a)
3-Cl-5-CF_Three             CF_Three          H H C (O) CH₂CH₂C≡CH
3-Cl-5-CF_Three             CF_Three          H H C (O) NHEt
3-Cl-5-CF_Three             CF_Three          H CH₂CH = CH₂  C (O) NHEt
3-Cl-5-CF_Three             CF_Three          H CH₂C≡CH C (O) NHEt
3-Cl-5-CF_Three             CF_Three          CH_Three        H C (O) NHEt
3-Cl-5-CF_Three             CF_Three          H H C (O) NHPr-c
3-Cl-5-CF_Three             CF_Three          CH_Three        H C (O) NHPr-c
3-Cl-5-CF_Three             CF_Three          H H C (O) NHCH₂CF_Three
3-Cl-5-CF_Three             CF_Three          CH_Three        H C (O) NHCH₂CF_Three
3-Cl-5-CF_Three             CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Cl-5-CF_Three             CF_Three          H H C (O) (T-23)
3-Cl-5-CF_Three             CF_Three          H H C (O) (T-33)
3-Cl-5-CF_Three             CF_Three          H H C (S) CH₂Pr-c
3-Cl-5-CF_Three             CF_Three          CH_Three        H C (S) CH₂Pr-c
3-Cl-5-CF_Three             CF₂Cl H H C (O) Et
3-Cl-5-CF_Three             CF₂Cl H H C (O) Pr-n
3-Cl-5-CF_Three             CF₂Cl H H C (O) Pr-i
3-Cl-5-CF_Three             CF₂Cl H H C (O) Pr-c
3-Cl-5-CF_Three             CF₂Cl CH_Three        H C (O) Pr-c
3-Cl-5-CF_Three             CF₂Cl H H C (O) Bu-i
3-Cl-5-CF_Three             CF₂Cl H H C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF₂Cl H H C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF₂Cl H H C (O) (E-6a)
3-Cl-5-CF_Three             CF₂Cl CH_Three        H C (O) (E-6a)
3-Cl-5-CF_Three             CF₂Cl H H C (O) NHPr-c
3-Cl-5-CF_Three             CF₂Cl CH_Three        H C (O) NHPr-c
3-Cl-5-CF_Three             CF₂Cl CH_Three        H C (O) NHCH₂C≡CH
3-Cl-5-CF_Three             CF₂Br H H C (O) Pr-n
3-Cl-5-CF_Three             CF₂Br H H C (O) Pr-c
3-Cl-5-CF_Three             CF₂Br H H C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF₂Br H H C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF₂Br H H C (O) (E-6a)
3-Cl-5-CF_Three             CF₂CHF₂      H H C (O) Pr-n
3-Cl-5-CF_Three             CF₂CHF₂      H H C (O) Pr-c
3-Cl-5-CF_Three             CF₂CHF₂      H H C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF₂CHF₂      H H C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF₂CHF₂      H H C (O) (E-6a)
3-Cl-5-CF_Three             CF₂CF_Three       H H C (O) Pr-n
3-Cl-5-CF_Three             CF₂CF_Three       H H C (O) Pr-c
3-Cl-5-CF_Three             CF₂CF_Three       H H C (O) CH₂Pr-c
3-Cl-5-CF_Three             CF₂CF_Three       H H C (O) CH₂CF_Three
3-Cl-5-CF_Three             CF₂CF_Three       H H C (O) (E-6a)
3-Br-5-CF_Three             CHF₂         H H C (O) Et
3-Br-5-CF_Three             CHF₂         H H C (O) Pr-n
3-Br-5-CF_Three             CHF₂         H H C (O) Pr-c
3-Br-5-CF_Three             CHF₂         H H C (O) CH₂Pr-c
3-Br-5-CF_Three             CHF₂         CH_Three        H C (O) CH₂Pr-c
3-Br-5-CF_Three             CHF₂         H H C (O) CH₂CF_Three
3-Br-5-CF_Three             CHF₂         CH_Three        H C (O) CH₂CF_Three
3-Br-5-CF_Three             CHF₂         H H C (O) (E-6a)
3-Br-5-CF_Three             CHF₂         CH_Three        H C (O) (E-6a)
3-Br-5-CF_Three             CHF₂         CH_Three        H C (O) NHPr-c
3-Br-5-CF_Three             CF_Three          H H H
3-Br-5-CF_Three             CF_Three          CH_Three        H H
3-Br-5-CF_Three             CF_Three          CN H H
3-Br-5-CF_Three             CF_Three          H H C (O) CH_Three
3-Br-5-CF_Three             CF_Three          H H C (O) Et
3-Br-5-CF_Three             CF_Three          H Et C (O) Et
3-Br-5-CF_Three             CF_Three          H CH₂Pr-c C (O) Et
3-Br-5-CF_Three             CF_Three          H CH₂OCH_Three    C (O) Et
3-Br-5-CF_Three             CF_Three          H CH₂CN C (O) Et
3-Br-5-CF_Three             CF_Three          H CH₂CH = CH₂  C (O) Et
3-Br-5-CF_Three             CF_Three          H CH₂C≡CH C (O) Et
3-Br-5-CF_Three             CF_Three          CH_Three        H C (O) Et
3-Br-5-CF_Three             CF_Three          CH_Three        Et C (O) Et
3-Br-5-CF_Three             CF_Three          CH_Three        CH₂Pr-c C (O) Et
3-Br-5-CF_Three             CF_Three          CH_Three        CH₂OCH_Three    C (O) Et
3-Br-5-CF_Three             CF_Three          CH_Three        CH₂CN C (O) Et
3-Br-5-CF_Three             CF_Three          CH_Three        CH₂C≡CH C (O) Et
3-Br-5-CF_Three             CF_Three          H H C (O) Pr-n
3-Br-5-CF_Three             CF_Three          H Et C (O) Pr-n
3-Br-5-CF_Three             CF_Three          H CH₂Pr-c C (O) Pr-n
3-Br-5-CF_Three             CF_Three          H CH₂OCH_Three    C (O) Pr-n
3-Br-5-CF_Three             CF_Three          H CH₂CN C (O) Pr-n
3-Br-5-CF_Three             CF_Three          H CH₂C≡CH C (O) Pr-n
3-Br-5-CF_Three             CF_Three          CH_Three        H C (O) Pr-n
3-Br-5-CF_Three             CF_Three          CF_Three        H C (O) Pr-n
3-Br-5-CF_Three             CF_Three          CN H C (O) Pr-n
3-Br-5-CF_Three             CF_Three          C≡CH H C (O) Pr-n
3-Br-5-CF_Three             CF_Three          H H C (O) Pr-i
3-Br-5-CF_Three             CF_Three          CH_Three        H C (O) Pr-i
3-Br-5-CF_Three             CF_Three          H H C (O) Pr-c
3-Br-5-CF_Three             CF_Three          H CH_Three        C (O) Pr-c
3-Br-5-CF_Three             CF_Three          H Et C (O) Pr-c
3-Br-5-CF_Three             CF_Three          H n-Pr C (O) Pr-c
3-Br-5-CF_Three             CF_Three          H CH₂Pr-c C (O) Pr-c
3-Br-5-CF_Three             CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-Br-5-CF_Three             CF_Three          H CH₂CN C (O) Pr-c
3-Br-5-CF_Three             CF_Three          H CH₂CH = CH₂  C (O) Pr-c
3-Br-5-CF_Three             CF_Three          H CH₂C≡CH C (O) Pr-c
3-Br-5-CF_Three             CF_Three          CH_Three        H C (O) Pr-c
3-Br-5-CF_Three             CF_Three          CH_Three        Et C (O) Pr-c
3-Br-5-CF_Three             CF_Three          CH_Three        CH₂Pr-c C (O) Pr-c
3-Br-5-CF_Three             CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-c
3-Br-5-CF_Three             CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-Br-5-CF_Three             CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-Br-5-CF_Three             CF_Three          CF_Three        H C (O) Pr-c
3-Br-5-CF_Three             CF_Three          CN H C (O) Pr-c
3-Br-5-CF_Three             CF_Three          C≡CH H C (O) Pr-c
3-Br-5-CF_Three             CF_Three          H H C (O) Bu-i
3-Br-5-CF_Three             CF_Three          H H C (O) CH₂Pr-c
3-Br-5-CF_Three             CF_Three          H Et C (O) CH₂Pr-c
3-Br-5-CF_Three             CF_Three          H CH₂Pr-c C (O) CH₂Pr-c
3-Br-5-CF_Three             CF_Three          H CH₂OCH_Three    C (O) CH₂Pr-c
3-Br-5-CF_Three             CF_Three          H CH₂CN C (O) CH₂Pr-c
3-Br-5-CF_Three             CF_Three          H CH₂CH = CH₂  C (O) CH₂Pr-c
3-Br-5-CF_Three             CF_Three          H CH₂C≡CH C (O) CH₂Pr-c
3-Br-5-CF_Three             CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Br-5-CF_Three             CF_Three          CF_Three        H C (O) CH₂Pr-c
3-Br-5-CF_Three             CF_Three          CN H C (O) CH₂Pr-c
3-Br-5-CF_Three             CF_Three          C≡CH H C (O) CH₂Pr-c
3-Br-5-CF_Three             CF_Three          H H C (O) (T-1)
3-Br-5-CF_Three             CF_Three          CH_Three        H C (O) (T-1)
3-Br-5-CF_Three             CF_Three          H H C (O) Bu-c
3-Br-5-CF_Three             CF_Three          H H C (O) CH₂CF_Three
3-Br-5-CF_Three             CF_Three          H Et C (O) CH₂CF_Three
3-Br-5-CF_Three             CF_Three          H CH₂Pr-c C (O) CH₂CF_Three
3-Br-5-CF_Three             CF_Three          H CH₂OCH_Three    C (O) CH₂CF_Three
3-Br-5-CF_Three             CF_Three          H CH₂CN C (O) CH₂CF_Three
3-Br-5-CF_Three             CF_Three          H CH₂C≡CH C (O) CH₂CF_Three
3-Br-5-CF_Three             CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Br-5-CF_Three             CF_Three          CF_Three        H C (O) CH₂CF_Three
3-Br-5-CF_Three             CF_Three          CN H C (O) CH₂CF_Three
3-Br-5-CF_Three             CF_Three          C≡CH H C (O) CH₂CF_Three
3-Br-5-CF_Three             CF_Three          H H C (O) CH₂CH₂CF_Three
3-Br-5-CF_Three             CF_Three          H H C (O) (E-6a)
3-Br-5-CF_Three             CF_Three          H Et C (O) (E-6a)
3-Br-5-CF_Three             CF_Three          H CH₂Pr-c C (O) (E-6a)
3-Br-5-CF_Three             CF_Three          H CH₂OCH_Three    C (O) (E-6a)
3-Br-5-CF_Three             CF_Three          H CH₂CN C (O) (E-6a)
3-Br-5-CF_Three             CF_Three          H CH₂C≡CH C (O) (E-6a)
3-Br-5-CF_Three             CF_Three          CH_Three        H C (O) (E-6a)
3-Br-5-CF_Three             CF_Three          CF_Three        H C (O) (E-6a)
3-Br-5-CF_Three             CF_Three          CN H C (O) (E-6a)
3-Br-5-CF_Three             CF_Three          C≡CH H C (O) (E-6a)
3-Br-5-CF_Three             CF_Three          H H C (O) CH₂CH₂C≡CH
3-Br-5-CF_Three             CF_Three          H H C (O) NHEt
3-Br-5-CF_Three             CF_Three          H CH₂CH = CH₂  C (O) NHEt
3-Br-5-CF_Three             CF_Three          H CH₂C≡CH C (O) NHEt
3-Br-5-CF_Three             CF_Three          CH_Three        H C (O) NHEt
3-Br-5-CF_Three             CF_Three          H H C (O) NHPr-c
3-Br-5-CF_Three             CF_Three          CH_Three        H C (O) NHPr-c
3-Br-5-CF_Three             CF_Three          H H C (O) NHCH₂CF_Three
3-Br-5-CF_Three             CF_Three          CH_Three        H C (O) NHCH₂CF_Three
3-Br-5-CF_Three             CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Br-5-CF_Three             CF_Three          H H C (O) (T-23)
3-Br-5-CF_Three             CF_Three          H H C (O) (T-33)
3-Br-5-CF_Three             CF_Three          H H C (S) CH₂Pr-c
3-Br-5-CF_Three             CF_Three          CH_Three        H C (S) CH₂Pr-c
3-Br-5-CF_Three             CF₂Cl H H C (O) Et
3-Br-5-CF_Three             CF₂Cl H H C (O) Pr-n
3-Br-5-CF_Three             CF₂Cl H H C (O) Pr-i
3-Br-5-CF_Three             CF₂Cl H H C (O) Pr-c
3-Br-5-CF_Three             CF₂Cl CH_Three        H C (O) Pr-c
3-Br-5-CF_Three             CF₂Cl H H C (O) Bu-i
3-Br-5-CF_Three             CF₂Cl H H C (O) CH₂Pr-c
3-Br-5-CF_Three             CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-Br-5-CF_Three             CF₂Cl H H C (O) CH₂CF_Three
3-Br-5-CF_Three             CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-Br-5-CF_Three             CF₂Cl H H C (O) (E-6a)
3-Br-5-CF_Three             CF₂Cl CH_Three        H C (O) (E-6a)
3-Br-5-CF_Three             CF₂Cl H H C (O) NHPr-c
3-Br-5-CF_Three             CF₂Cl CH_Three        H C (O) NHPr-c
3-Br-5-CF_Three             CF₂Cl CH_Three        H C (O) NHCH₂C≡CH
3-Br-5-CF_Three             CF₂Br H H C (O) Pr-n
3-Br-5-CF_Three             CF₂Br H H C (O) Pr-c
3-Br-5-CF_Three             CF₂Br H H C (O) CH₂Pr-c
3-Br-5-CF_Three             CF₂Br H H C (O) CH₂CF_Three
3-Br-5-CF_Three             CF₂Br H H C (O) (E-6a)
3-Br-5-CF_Three             CF₂CHF₂      H H C (O) Pr-n
3-Br-5-CF_Three             CF₂CHF₂      H H C (O) Pr-c
3-Br-5-CF_Three             CF₂CHF₂      H H C (O) CH₂Pr-c
3-Br-5-CF_Three             CF₂CHF₂      H H C (O) CH₂CF_Three
3-Br-5-CF_Three             CF₂CHF₂      H H C (O) (E-6a)
3-Br-5-CF_Three             CF₂CF_Three       H H C (O) Pr-n
3-Br-5-CF_Three             CF₂CF_Three       H H C (O) Pr-c
3-Br-5-CF_Three             CF₂CF_Three       H H C (O) CH₂Pr-c
3-Br-5-CF_Three             CF₂CF_Three       H H C (O) CH₂CF_Three
3-Br-5-CF_Three             CF₂CF_Three       H H C (O) (E-6a)
3-I-5-CF_Three              CHF₂         H H C (O) Pr-n
3-I-5-CF_Three              CHF₂         H H C (O) Pr-c
3-I-5-CF_Three              CHF₂         H H C (O) CH₂Pr-c
3-I-5-CF_Three              CHF₂         H H C (O) CH₂CF_Three
3-I-5-CF_Three              CHF₂         H H C (O) (E-6a)
3-I-5-CF_Three              CF_Three          H H C (O) Et
3-I-5-CF_Three              CF_Three          H Et C (O) Et
3-I-5-CF_Three              CF_Three          H CH₂C≡CH C (O) Et
3-I-5-CF_Three              CF_Three          CH_Three        H C (O) Et
3-I-5-CF_Three              CF_Three          H H C (O) Pr-n
3-I-5-CF_Three              CF_Three          H Et C (O) Pr-n
3-I-5-CF_Three              CF_Three          CH_Three        H C (O) Pr-n
3-I-5-CF_Three              CF_Three          H H C (O) Pr-i
3-I-5-CF_Three              CF_Three          CH_Three        H C (O) Pr-i
3-I-5-CF_Three              CF_Three          H H C (O) Pr-c
3-I-5-CF_Three              CF_Three          H Et C (O) Pr-c
3-I-5-CF_Three              CF_Three          H CH₂Pr-c C (O) Pr-c
3-I-5-CF_Three              CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-I-5-CF_Three              CF_Three          H CH₂C≡CH C (O) Pr-c
3-I-5-CF_Three              CF_Three          CH_Three        H C (O) Pr-c
3-I-5-CF_Three              CF_Three          CH_Three        Et C (O) Pr-c
3-I-5-CF_Three              CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-I-5-CF_Three              CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-I-5-CF_Three              CF_Three          H H C (O) Bu-i
3-I-5-CF_Three              CF_Three          H H C (O) CH₂Pr-c
3-I-5-CF_Three              CF_Three          H Et C (O) CH₂Pr-c
3-I-5-CF_Three              CF_Three          CH_Three        H C (O) CH₂Pr-c
3-I-5-CF_Three              CF_Three          H H C (O) CH₂CF_Three
3-I-5-CF_Three              CF_Three          CH_Three        H C (O) CH₂CF_Three
3-I-5-CF_Three              CF_Three          H H C (O) (E-6a)
3-I-5-CF_Three              CF_Three          CH_Three        H C (O) (E-6a)
3-I-5-CF_Three              CF_Three          H H C (O) NHEt
3-I-5-CF_Three              CF_Three          H H C (O) NHPr-c
3-I-5-CF_Three              CF_Three          CH_Three        H C (O) NHPr-c
3-I-5-CF_Three              CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-I-5-CF_Three              CF₂Cl H H C (O) Et
3-I-5-CF_Three              CF₂Cl H H C (O) Pr-n
3-I-5-CF_Three              CF₂Cl H H C (O) Pr-c
3-I-5-CF_Three              CF₂Cl H H C (O) CH₂Pr-c
3-I-5-CF_Three              CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-I-5-CF_Three              CF₂Cl H H C (O) CH₂CF_Three
3-I-5-CF_Three              CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-I-5-CF_Three              CF₂Cl H H C (O) (E-6a)
3-I-5-CF_Three              CF₂Cl CH_Three        H C (O) (E-6a)
3-I-5-CF_Three              CF₂Cl CH_Three        H C (O) NHPr-c
3-I-5-CF_Three              CF₂Br H H C (O) CH₂Pr-c
3-I-5-CF_Three              CF₂CHF₂      H H C (O) CH₂CF_Three
3-I-5-CF_Three              CF₂CF_Three       H H C (O) (E-6a)
3-CH_Three-5-CF_Three            CF_Three          H H C (O) Et
3-CH_Three-5-CF_Three            CF_Three          H H C (O) Pr-n
3-CH_Three-5-CF_Three            CF_Three          H H C (O) Pr-c
3-CH_Three-5-CF_Three            CF_Three          H H C (O) CH₂Pr-c
3-CH_Three-5-CF_Three            CF_Three          CH_Three        H C (O) CH₂Pr-c
3-CH_Three-5-CF_Three            CF_Three          H H C (O) CH₂CF_Three
3-CH_Three-5-CF_Three            CF_Three          CH_Three        H C (O) CH₂CF_Three
3-CH_Three-5-CF_Three            CF_Three          H H C (O) (E-6a)
3-CH_Three-5-CF_Three            CF_Three          CH_Three        H C (O) (E-6a)
3-CH_Three-5-CF_Three            CF_Three          CH_Three        H C (O) NHPr-c
3-CH_Three-5-CF_Three            CF₂Cl H H C (O) CH₂CF_Three
3-Et-5-CF_Three             CF_Three          H H C (O) (E-6a)
3-i-Pr-5-CF_Three           CF_Three          H H C (O) Pr-n
3,5- (CF_Three)₂             CH_Three          H H C (O) Pr-c
3,5- (CF_Three)₂             Et H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             n-Pr H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             i-Pr H H C (O) (E-6a)
3,5- (CF_Three)₂             c-Pr H H C (O) Pr-n
3,5- (CF_Three)₂             CH₂F H H C (O) Pr-c
3,5- (CF_Three)₂             CH₂Cl H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CH₂Br H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CH₂I H H C (O) (E-6a)
3,5- (CF_Three)₂             CHF₂         H H C (O) Et
3,5- (CF_Three)₂             CHF₂         H H C (O) Pr-n
3,5- (CF_Three)₂             CHF₂         H H C (O) Pr-i
3,5- (CF_Three)₂             CHF₂         H H C (O) Pr-c
3,5- (CF_Three)₂             CHF₂         CH_Three        H C (O) Pr-c
3,5- (CF_Three)₂             CHF₂         H H C (O) Bu-i
3,5- (CF_Three)₂             CHF₂         H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CHF₂         CH_Three        H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CHF₂         H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CHF₂         CH_Three        H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CHF₂         H H C (O) (E-6a)
3,5- (CF_Three)₂             CHF₂         CH_Three        H C (O) (E-6a)
3,5- (CF_Three)₂             CHF₂         H H C (O) NHPr-c
3,5- (CF_Three)₂             CHF₂         CH_Three        H C (O) NHPr-c
3,5- (CF_Three)₂             CHF₂         CH_Three        H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CHFCl H H C (O) Pr-n
3,5- (CF_Three)₂             CHCl₂        H H C (O) Pr-c
3,5- (CF_Three)₂             CHFBr H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H H H
3,5- (CF_Three)₂             CF_Three          CH_Three        H H
3,5- (CF_Three)₂             CF_Three          CN H H
3,5- (CF_Three)₂             CF_Three          H H CHO
3,5- (CF_Three)₂             CF_Three          H H C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H Et C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H CH₂Pr-c C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H CH₂OCH_Three    C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H CH₂CN C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H CH₂CH = CH₂  C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H CH₂C≡CH C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH_Three        C (O) Et
3,5- (CF_Three)₂             CF_Three          H Et C (O) Et
3,5- (CF_Three)₂             CF_Three          H n-Pr C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂Pr-c C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂OCH_Three    C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂OEt C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂OCH₂CF_Three       C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) CH_Three      C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) OCH_Three     C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) CH_Three     C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) OCH_Three    C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂SCH_Three          C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂CN C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) OCH_Three      C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NH₂       C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHCH_Three     C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) N (CH_Three)₂   C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHEt C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂C (S) NH₂       C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂CH = CH₂  C (O) Et
3,5- (CF_Three)₂             CF_Three          H CH₂C≡CH C (O) Et
3,5- (CF_Three)₂             CF_Three          H SCCl_Three      C (O) Et
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) Et
3,5- (CF_Three)₂             CF_Three          CH_Three(R) H C (O) Et
3,5- (CF_Three)₂             CF_Three          CH_Three(S) H C (O) Et
3,5- (CF_Three)₂             CF_Three          CH_Three        CH_Three        C (O) Et
3,5- (CF_Three)₂             CF_Three          CH_Three        Et C (O) Et
3,5- (CF_Three)₂             CF_Three          CH_Three        n-Pr C (O) Et
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂Pr-c C (O) Et
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂OCH_Three    C (O) Et
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CN C (O) Et
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CH = CH₂  C (O) Et
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂C≡CH C (O) Et
3,5- (CF_Three)₂             CF_Three          CF_Three        H C (O) Et
3,5- (CF_Three)₂             CF_Three          CN H C (O) Et
3,5- (CF_Three)₂             CF_Three          CN (R) H C (O) Et
3,5- (CF_Three)₂             CF_Three          CN (S) H C (O) Et
3,5- (CF_Three)₂             CF_Three          CN Et C (O) Et
3,5- (CF_Three)₂             CF_Three          CN CH₂Pr-c C (O) Et
3,5- (CF_Three)₂             CF_Three          CN CH₂CN C (O) Et
3,5- (CF_Three)₂             CF_Three          CN CH₂CH = CH₂  C (O) Et
3,5- (CF_Three)₂             CF_Three          CN CH₂C≡CH C (O) Et
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    H C (O) Et
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(R) H C (O) Et
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(S) H C (O) Et
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    Et C (O) Et
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    CH₂Pr-c C (O) Et
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    CH₂CH = CH₂  C (O) Et
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    CH₂C≡CH C (O) Et
3,5- (CF_Three)₂             CF_Three          C≡CH H C (O) Et
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) Et
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) Et
3,5- (CF_Three)₂             CF_Three          Ph H C (O) Et
3,5- (CF_Three)₂             CF_Three          D-21a H C (O) Et
3,5- (CF_Three)₂             CF_Three          H H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH_Three        C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H Et C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H n-Pr C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂Pr-c C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂OCH_Three    C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂OEt C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) CH_Three      C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) OCH_Three     C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) CH_Three     C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) OCH_Three    C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂SCH_Three          C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂CN C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NH₂       C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHCH_Three     C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) N (CH_Three)₂   C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHEt C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂C (S) NH₂       C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂CH = CH₂  C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H CH₂C≡CH C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          CH_Three(R) H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          CH_Three(S) H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          CH_Three        Et C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂Pr-c C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CN C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CH = CH₂  C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂C≡CH C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          CF_Three        H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          CN H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          CN (R) H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          CN (S) H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(R) H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(S) H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          C≡CH H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          Ph H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          D-21a H C (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          H Et C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          H CH₂Pr-c C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          H CH₂OCH_Three    C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          H CH₂CN C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          H CH₂CH = CH₂  C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          H CH₂C≡CH C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          CH_Three(R) H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          CH_Three(S) H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          CF_Three        H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          CN H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          CN (R) H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          CN (S) H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(R) H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(S) H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          C≡CH H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          Ph H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          D-21a H C (O) Pr-i
3,5- (CF_Three)₂             CF_Three          H H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH_Three        C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H Et C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H n-Pr C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H c-Pr C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂Pr-c C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂CF_Three     C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OCH_Three    C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OEt C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OCH₂CH₂Cl C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OCH₂CHF₂      C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OCH₂CF_Three       C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OCH₂CH₂OCH_Three   C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OCH₂Ph C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) CH_Three      C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) Et C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) Pr-n C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) Pr-i C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) Pr-c C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) Bu-n C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) Bu-i C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) Bu-s C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) Bu-t C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) CH₂Ph C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) Ph C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) OCH_Three     C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) OEt C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) OBu-n C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) OBu-i C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) OCH₂Ph C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) OPh C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) NHPh C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OPh C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂CH₂OCH_Three       C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂SCH_Three          C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂SO₂CH_Three        C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂SC (O) CH_Three      C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂SC (O) Et C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂SC (O) Ph C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂SC (S) OCH_Three     C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂SC (S) OEt C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂SC (S) OPr-n C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂SC (S) OPr-i C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂SC (S) N (CH_Three)₂  C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂SC (S) (T-23) C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂CH₂SCH_Three       C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂N (CH_Three)₂       C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) CH_Three     C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂N (CH_Three) C (O) CH_Three       C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) Et C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) Pr-i C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) Pr-c C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) Bu-t C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) Ph C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) OCH_Three          C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂N (CH_Three) C (O) OCH_Three      C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) OEt C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂N (CH_Three) SO₂CH_Three        C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂CN C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) OCH_Three      C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NH₂       C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHCH_Three     C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) N (CH_Three)₂   C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHEt C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHPr-n C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHPr-i C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHPr-c C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHCH₂CF_Three  C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (S) NH₂       C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂CH = CH₂  C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C≡CH C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H C (O) CH_Three    C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H C (O) Et C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H C (O) OCH_Three   C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H C (O) OEt C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H C (O) SCH_Three   C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H C (S) OCH_Three   C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H C (S) SCH_Three   C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H OCH_Three       C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H OEt C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H SCCl_Three      C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H SN (Bu-n)₂  C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H S (T-31) C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H SN (Pr-i) CH₂CH₂C (O) OEt C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H SN (CH₂Ph) CH₂CH₂C (O) OEt C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H SN (CH_Three) C (O) OBu-n C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three(R) H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three(S) H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH_Three        C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        Et C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        n-Pr C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂Pr-c C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CN C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CH = CH₂  C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          Et H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          n-Pr H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          i-Pr H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          c-Pr H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CF_Three        H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CF_Three(R) H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CF_Three(S) H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CN H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CN (R) H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CN (S) H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CN Et C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CN CH₂Pr-c C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CN CH₂CN C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CN CH₂CH = CH₂  C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          CN CH₂C≡CH C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          C (O) OCH_Three   H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          C (O) NH₂    H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(R) H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(S) H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    Et C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    CH₂Pr-c C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    CH₂CH = CH₂  C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    CH₂C≡CH C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          C≡CH H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          Ph H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          Ph-2-F H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          Ph-3-F H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          Ph-4-F H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          D-1a H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          D-2a H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          D-3a H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          D-4a H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          D-18a H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          D-21a H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          D-52a H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          D-53a H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          D-54a H C (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H H C (O) Bu-n
3,5- (CF_Three)₂             CF_Three          H H C (O) Bu-i
3,5- (CF_Three)₂             CF_Three          H Et C (O) Bu-i
3,5- (CF_Three)₂             CF_Three          H CH₂Pr-c C (O) Bu-i
3,5- (CF_Three)₂             CF_Three          H CH₂OCH_Three    C (O) Bu-i
3,5- (CF_Three)₂             CF_Three          H CH₂CN C (O) Bu-i
3,5- (CF_Three)₂             CF_Three          H CH₂CH = CH₂  C (O) Bu-i
3,5- (CF_Three)₂             CF_Three          H CH₂C≡CH C (O) Bu-i
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) Bu-i
3,5- (CF_Three)₂             CF_Three          CH_Three(R) H C (O) Bu-i
3,5- (CF_Three)₂             CF_Three          CH_Three(S) H C (O) Bu-i
3,5- (CF_Three)₂             CF_Three          CN H C (O) Bu-i
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH_Three        C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H Et C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H n-Pr C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂Pr-c C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OCH_Three    C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OEt C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) CH_Three      C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) OCH_Three     C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂SCH_Three          C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) CH_Three     C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) OCH_Three    C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂CN C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NH₂       C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHCH_Three     C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) N (CH_Three)₂   C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHEt C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C (S) NH₂       C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂CH = CH₂  C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C≡CH C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three(R) H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three(S) H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        Et C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂Pr-c C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂OCH_Three    C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CN C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CH = CH₂  C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂C≡CH C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CF_Three        H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CN H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CN (R) H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CN (S) H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(R) H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(S) H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          C≡CH H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          Ph H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          D-21a H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H H C (O) Bu-s
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-1)
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) (T-1)
3,5- (CF_Three)₂             CF_Three          CN H C (O) (T-1)
3,5- (CF_Three)₂             CF_Three          H H C (O) Bu-c
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) Bu-c
3,5- (CF_Three)₂             CF_Three          CN H C (O) Bu-c
3,5- (CF_Three)₂             CF_Three          H H C (O) Bu-t
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-2)
3,5- (CF_Three)₂             CF_Three          H H C (O) Pen-n
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂Bu-i
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂Bu-s
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(T-1)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂Bu-c
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂Bu-t
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-3)
3,5- (CF_Three)₂             CF_Three          H H C (O) Pen-c
3,5- (CF_Three)₂             CF_Three          H H C (O) Hex-n
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(T-3)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂Pen-c
3,5- (CF_Three)₂             CF_Three          H H C (O) Hex-c
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂Hex-c
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-4)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂F
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂Br
3,5- (CF_Three)₂             CF_Three          H H C (O) CHF₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CHFCl
3,5- (CF_Three)₂             CF_Three          H H C (O) CHCl₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CHFBr
3,5- (CF_Three)₂             CF_Three          H H C (O) CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CF₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) CFCl₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CCl_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CF₂Br
3,5- (CF_Three)₂             CF_Three          H H C (O) CFClBr
3,5- (CF_Three)₂             CF_Three          H H C (O) CCl₂Br
3,5- (CF_Three)₂             CF_Three          H H C (O) CF₂I
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂F
3,5- (CF_Three)₂             CF_Three          H H C (O) CHFCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) CHClCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CHClCH_Three(R)
3,5- (CF_Three)₂             CF_Three          H H C (O) CHClCH_Three(S)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂Br
3,5- (CF_Three)₂             CF_Three          H H C (O) CHBrCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHF₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHFCl
3,5- (CF_Three)₂             CF_Three          H H C (O) CFClCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHCl₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CHClCH₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHFBr
3,5- (CF_Three)₂             CF_Three          H H C (O) CHBrCH₂F
3,5- (CF_Three)₂             CF_Three          H H C (O) CHClCH₂Br
3,5- (CF_Three)₂             CF_Three          H H C (O) CHBrCH₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) CClBrCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CHBrCH₂Br
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH_Three        C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H Et C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H n-Pr C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂Pr-c C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂OCH_Three    C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂OEt C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) CH_Three      C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) OCH_Three     C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) CH_Three      C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) OCH_Three     C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂SCH_Three          C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) CH_Three     C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) OCH_Three    C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂CN C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NH₂       C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHCH_Three     C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) N (CH_Three)₂   C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHEt C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂C (S) NH₂       C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂CH = CH₂  C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂C≡CH C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CH_Three(R) H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CH_Three(S) H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CH_Three        Et C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂Pr-c C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂OCH_Three    C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CN C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CH = CH₂  C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂C≡CH C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CF_Three        H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CF_Three(R) H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CF_Three(S) H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CN H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CN (R) H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CN (S) H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(R) H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(S) H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          C≡CH H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          Ph H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          D-21a H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CF₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CFCl₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CCl_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CF₂Br
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CFClBr
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CCl₂Br
3,5- (CF_Three)₂             CF_Three          H H C (O) CF₂CHF₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CHClCF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CF₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHFCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CHFCH₂CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) CH₂F
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) CH₂F (R)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) CH₂F (S)
3,5- (CF_Three)₂             CF_Three          H H C (O) CF (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-5)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂CH₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHClCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHClCH_Three(R)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHClCH_Three(S)
3,5- (CF_Three)₂             CF_Three          H H C (O) CHClCH₂CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) CH₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-6)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHBrCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) CH₂Br
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) CH₂Br (R)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) CH₂Br (S)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-7)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-8)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CFClCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHClCH₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-9)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHBrCH₂F
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHClCH₂Br
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHBrCH₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CClBrCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHBrCH₂Br
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-10)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂OCH_Three    C (O) CH₂CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H CH₂C≡CH C (O) CH₂CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) CH₂CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CN H C (O) CH₂CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂CF₂Br
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CF₂CHF₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHClCF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CF₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CF₂CHFCF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CF₂CF₂CHF₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CF₂CF₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHFCH₂CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CHClCH₂CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CF (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(T-5)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(T-6)
3,5- (CF_Three)₂             CF_Three          H H C (O) C (CH_Three)₂CH₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(T-8)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(T-9)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-11)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(T-10)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH (CH_ThreeCF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-12)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-18)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CF₂CHFCF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CF₂CF₂CHF₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH (CF_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CF₂CF₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(T-17)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OEt
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OPr-n
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OPr-i
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OPr-c
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OCH₂CH₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OCH₂CH₂OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OCH₂CH₂SCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OCH₂Ph
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OC (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OC (O) CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OC (O) NHCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OC (O) N (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OC (S) NHCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OC (S) N (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OPh
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂O (Ph-2-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂O (Ph-3-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂O (Ph-4-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OP (O) (OEt)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OP (S) (OCH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂OP (S) (OEt)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) OCH_Three(R)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) OCH_Three(S)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) OC (O) NHCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) OC (O) N (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) OC (O) NHEt
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) OC (O) NHCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-5a)
3,5- (CF_Three)₂             CF_Three          H H C (O) C (CH_Three)₂OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂OEt
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-5a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-24a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) CH₂OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) CH₂OCH_Three(R)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) CH₂OCH_Three(S)
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH_Three        C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H Et C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H n-Pr C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂Pr-c C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂OCH_Three    C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂OEt C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) CH_Three      C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂OC (O) OCH_Three     C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂SCH_Three          C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) CH_Three     C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂NHC (O) OCH_Three    C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂CN C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NH₂       C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHCH_Three     C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) N (CH_Three)₂   C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂C (O) NHEt C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂C (S) NH₂       C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂CH = CH₂  C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H CH₂C≡CH C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CH_Three(R) H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CH_Three(S) H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CH_Three        Et C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂Pr-c C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂OCH_Three    C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CN C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CH = CH₂  C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂C≡CH C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CF_Three        H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CF_Three(R) H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CF_Three(S) H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CN H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CN (R) H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          CN (S) H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(R) H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(S) H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          C≡CH H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          Ph H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          D-21a H C (O) (E-6a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-25a)
3,5- (CF_Three)₂             CF_Three          H H C (O) C (CH_Three)₂CH₂OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂CH₂OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-6a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-25a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-26a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-26a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CF_Three) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH (OCH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH (OEt)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-11a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-11b) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-12a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-12b) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-12c)
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-35a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂(E-11a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂SCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂S (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂SO₂CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-7a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-7b)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-7c)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-27a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-27b)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-27c)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂CH₂SCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-8a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-8b)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-8c)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-28a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-28b)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-28c)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-29a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-29b)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(E-29c)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂N (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂N (CH_Three) Et
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂N (Et)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(T-23)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHC (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHC (O) Et
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHC (O) Pr-c
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHC (O) CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHC (O) Ph
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHC (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂N (CH_Three) C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂N (Et) C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHC (O) OEt
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHC (O) OBu-t
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHC (O) SCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHC (O) N (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHC (S) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHC (S) SCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHC (S) NHEt
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHSO₂CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHSO₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHSO₂N (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHP (S) (OCH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂NHP (S) (OEt)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) NHC (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) NHC (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-9a) C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-9a) C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) C (CH_Three)₂NHC (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) C (CH_Three)₂NHC (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂NHC (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-10a) C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-10a) C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-31a) C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-31a) C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-32a) C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-32a) C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-21a) H
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-21a) C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-21a) C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-22a) H
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-22a) C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (E-22a) C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂Si (CH_Three)_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) C (CH_Three)₂CHO
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH = NOCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (CH_Three) = NOCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CN
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) CN
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-13)
3,5- (CF_Three)₂             CF_Three          H H C (O) C (CH_Three)₂CN
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (O) SCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (O) NH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (O) NHCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (O) N (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (O) NHEt
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (O) NHPr-n
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (O) NHPr-i
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (O) (T-23)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) C (O) NH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) C (O) NHCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (OCH_Three) = NH
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (OEt) = NH
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(M-11a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂[(M-11b) CF_Three]
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂[(M-11c) CF_Three]
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(M-28a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (S) SCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (S) NH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) C (S) NH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (SCH_Three) = NH
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(M-14a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂[(M-14b) CF_Three]
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂[(M-14c) CF_Three]
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(M-32a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (NH₂) = NH
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂[(M-17a) H]
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂[(M-36a) H]
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂C (NH₂) = NOH
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂SO₂NH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂SO₂NHCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂SO₂N (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂SO₂NHEt
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = CH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = CHCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH = CH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) C (CH_Three) = CH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = CHEt
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH = CHCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂CH = CH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = C (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) C (CH_Three) = CHCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-19)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(T-20)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-21)
3,5- (CF_Three)₂             CF_Three          H H C (O) CF = CH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = CHCl
3,5- (CF_Three)₂             CF_Three          H H C (O) CCl = CH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = CHBr
3,5- (CF_Three)₂             CF_Three          H H C (O) CBr = CH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = CCl₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CCl = CHCl
3,5- (CF_Three)₂             CF_Three          H H C (O) CBr = CHBr
3,5- (CF_Three)₂             CF_Three          H H C (O) CCl = CCl₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = CClCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) C (CH_Three) = CHBr
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = CBrCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) C (CF_Three) = CH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = CClCF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-14)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-15)
3,5- (CF_Three)₂             CF_Three          H H C (O) C (OCH_Three) = CH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CBr = CHOCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) C≡CH
3,5- (CF_Three)₂             CF_Three          H H C (O) C≡CCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂CH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) CH₂CH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CN H C (O) CH₂CH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H H C (O) C≡CCl
3,5- (CF_Three)₂             CF_Three          H H C (O) C≡CBr
3,5- (CF_Three)₂             CF_Three          H H C (O) C≡CI
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂Ph
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(Ph-2-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(Ph-3-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(Ph-4-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) Ph
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) Ph (R)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH (CH_Three) Ph (S)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-16)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(D-52a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(D-53a)
3,5- (CF_Three)₂             CF_Three          H H C (O) CH₂(D-54a)
3,5- (CF_Three)₂             CF_Three          H -CH₂CH₂C (O)-
3,5- (CF_Three)₂             CF_Three          H -CH₂CH₂CH₂C (O)-
3,5- (CF_Three)₂             CF_Three          H -CH₂CH₂CH₂CH₂C (O)-
3,5- (CF_Three)₂             CF_Three          H -CH₂CH₂CH₂CH₂CH₂C (O)-
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = NOCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = NOEt
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = NOCH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = NOCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = NOCH₂CN
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = NOCH₂CH = CH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = NOCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H H C (O) CH = NOCH₂Ph
3,5- (CF_Three)₂             CF_Three          H H C (O) C (CH_Three) = NOCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) C (CH_Three) = NOCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) C (O) NHCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) Ph
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-3-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-4-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2-Cl)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-4-Cl)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2-Br)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-4-Br)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2-I)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2-CH_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-4-CH_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2-CF_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-4-CF_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2-OCH_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-4-OCH_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2-OCHF₂)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-4-OCHF₂)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2-SCH_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) [Ph-2-S (O) CH_Three]
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2-SO₂CH_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-4-SCH_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) [Ph-4-S (O) CH_Three]
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-4-SO₂CH_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-4-SCF_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2-NO₂)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-4-NO₂)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-4-CN)
3,5- (CF_Three)₂             CF_Three          H H C (O) [Ph-4-C (S) NH₂]
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2,3-F₂)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2,4-F₂)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2,5-F₂)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2,6-F₂)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-3,4-F₂)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-3,5-F₂)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2-Cl-4-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2,4-Cl₂)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2,6-Cl₂)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2-F-4-CN)
3,5- (CF_Three)₂             CF_Three          H H C (O) (Ph-2,4,6-F_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) (1-Naph)
3,5- (CF_Three)₂             CF_Three          H H C (O) (2-Naph)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-1a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-2a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-3a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-3b) Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-4a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-8a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-9a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-10a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-10b) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-11b) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-12a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-13a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-13b) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-14a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-15a) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-16a) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-16c) Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-17a) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-17b) Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-18a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-21a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-22a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-23a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-24a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-28a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-29a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-29b) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-30b) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-31b) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-32a) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-33a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-34a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-35a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-36a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-36b) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-37a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-38a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-41a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-44a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-52a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-52b) F
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-52b) Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-52b) Br
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-52b) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-52b) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-52b) SCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-52d) F
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-52d) Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53b) F
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53b) Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53b) Br
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53b) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53b) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53b) SCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53b) CN
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53c) Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53c) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53c) CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53c) CH₂OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53e) F
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53e) Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-53e) CN
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-54a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-54c) Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-54c) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-54c) NO₂
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-54c) CN
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-54e)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-55a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-56a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-57a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-58a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-59a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-60a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-61a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-62a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (D-63a)
3,5- (CF_Three)₂             CF_Three          H H C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) OEt
3,5- (CF_Three)₂             CF_Three          H H C (O) OPr-i
3,5- (CF_Three)₂             CF_Three          H H C (O) OBu-i
3,5- (CF_Three)₂             CF_Three          H H C (O) OBu-t
3,5- (CF_Three)₂             CF_Three          H H C (O) OCH₂CH₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) OCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) OCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H -C (= CH₂) CH₂OC (O)-
3,5- (CF_Three)₂             CF_Three          H H C (O) OPh
3,5- (CF_Three)₂             CF_Three          H H C (O) SCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) SEt
3,5- (CF_Three)₂             CF_Three          H H C (O) NH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) N (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) NHEt
3,5- (CF_Three)₂             CF_Three          H Et C (O) NHEt
3,5- (CF_Three)₂             CF_Three          H CH₂Pr-c C (O) NHEt
3,5- (CF_Three)₂             CF_Three          H CH₂OCH_Three    C (O) NHEt
3,5- (CF_Three)₂             CF_Three          H CH₂CN C (O) NHEt
3,5- (CF_Three)₂             CF_Three          H CH₂CH = CH₂  C (O) NHEt
3,5- (CF_Three)₂             CF_Three          H CH₂C≡CH C (O) NHEt
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) NHEt
3,5- (CF_Three)₂             CF_Three          CN H C (O) NHEt
3,5- (CF_Three)₂             CF_Three          H H C (O) N (Et)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) NHPr-n
3,5- (CF_Three)₂             CF_Three          H H C (O) NHPr-i
3,5- (CF_Three)₂             CF_Three          H H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          H Et C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          H CH₂Pr-c C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          H CH₂OCH_Three    C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          H CH₂CN C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          H CH₂CH = CH₂  C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          H CH₂C≡CH C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CH_Three(R) H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CH_Three(S) H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        Et C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂Pr-c C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂OCH_Three    C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CN C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂C≡CH C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          Et H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          n-Pr H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          i-Pr H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          c-Pr H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CF_Three        H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CF_Three(R) H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CF_Three(S) H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CN H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CN (R) H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          CN (S) H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          C (O) OCH_Three   H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          C (O) NH₂    H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(R) H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(S) H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          C≡CH H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          Ph H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          Ph-2-F H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          Ph-3-F H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          Ph-4-F H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          D-1a H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          D-2a H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          D-3a H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          D-4a H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          D-18a H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          D-21a H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          D-52a H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          D-53a H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          D-54a H C (O) NHPr-c
3,5- (CF_Three)₂             CF_Three          H H C (O) NHBu-n
3,5- (CF_Three)₂             CF_Three          H H C (O) NHBu-i
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H H C (O) NHBu-s
3,5- (CF_Three)₂             CF_Three          H H C (O) NHBu-c
3,5- (CF_Three)₂             CF_Three          H H C (O) NHBu-t
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂Bu-t
3,5- (CF_Three)₂             CF_Three          H H C (O) NHPen-c
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) NHCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CN H C (O) NHCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) N (CH_Three) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂CH₂OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂CH₂SCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂CH₂SO₂CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂CH₂SEt
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂CH₂SO₂Et
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂CH₂N (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂Si (CH_Three)_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂CN
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂C (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂C (O) OEt
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂CH = CH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H Et C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H CH₂Pr-c C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H CH₂OCH_Three    C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H CH₂CN C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H CH₂CH = CH₂  C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H CH₂C≡CH C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CH_Three(R) H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CH_Three(S) H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CH_Three        Et C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂Pr-c C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂OCH_Three    C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂CN C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CH_Three        CH₂C≡CH C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CF_Three        H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CN H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CN (R) H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          CN (S) H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          C (S) NH₂    H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(R) H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          C (S) NH₂(S) H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          C≡CH H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          C≡CH (R) H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          Ph H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          D-21a H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H H C (O) N (CH_Three) CH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂Ph
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂(Ph-2-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂(Ph-3-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂(Ph-4-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂(Ph-4-Cl)
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂(Ph-4-CF_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂(D-1d) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂(D-22a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂(D-52a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂(D-53a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NHCH₂(D-54a)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-22)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-23)
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) (T-23)
3,5- (CF_Three)₂             CF_Three          CN H C (O) (T-23)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-24)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-25)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-26)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-27)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-28)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-29)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-30)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-31)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-32)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-33)
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (O) (T-33)
3,5- (CF_Three)₂             CF_Three          CN H C (O) (T-33)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-34)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-35)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-36)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-37)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-38)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-39)
3,5- (CF_Three)₂             CF_Three          H H C (O) (T-40)
3,5- (CF_Three)₂             CF_Three          H H C (O) NHC (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHC (O) Ph
3,5- (CF_Three)₂             CF_Three          H H C (O) NHC (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHC (O) OCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (M-14a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (M-32a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NHPh
3,5- (CF_Three)₂             CF_Three          H H C (O) N (CH_Three) Ph
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (Ph-2-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (Ph-3-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (Ph-4-F)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (Ph-2-Cl)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (Ph-3-Cl)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (Ph-4-Cl)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (Ph-4-CF_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (Ph-2-OCH_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (Ph-4-OCH_Three)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (Ph-4-CN)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (D-3a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (D-4a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (D-52a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (D-53a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (D-54a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (D-55a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (D-56a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (D-57a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (D-58a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (D-59a)
3,5- (CF_Three)₂             CF_Three          H H C (O) NHOCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) N (CH_Three) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHOEt
3,5- (CF_Three)₂             CF_Three          H H C (O) NHOCH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H H C (O) NHOCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHOCH₂CN
3,5- (CF_Three)₂             CF_Three          H H C (O) NHOCH₂CH = CH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) NHOCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H H C (O) NHOCH₂Ph
3,5- (CF_Three)₂             CF_Three          H H C (O) NNH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) N (CH_Three) NH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) N (Et) NH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) N (Bu-t) NH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) N (CH₂Ph) NH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) NHN (CH_Three)₂
3,5- (CF_Three)₂             CF_Three          H H C (O) NHNHBu-t
3,5- (CF_Three)₂             CF_Three          H H C (O) NH (T-37)
3,5- (CF_Three)₂             CF_Three          H H C (O) NHNHC (O) CH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHNHC (O) Et
3,5- (CF_Three)₂             CF_Three          H H C (O) NHNHC (O) Pr-n
3,5- (CF_Three)₂             CF_Three          H H C (O) NHNHC (O) Pr-i
3,5- (CF_Three)₂             CF_Three          H H C (O) NHNHC (O) Ph
3,5- (CF_Three)₂             CF_Three          H H C (O) NHNHC (O) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHNHC (O) OEt
3,5- (CF_Three)₂             CF_Three          H H C (O) NHNHC (O) NH₂
3,5- (CF_Three)₂             CF_Three          H H C (O) NHNHC (S) NHCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (O) NHN (CH_Three) Ph
3,5- (CF_Three)₂             CF_Three          H H C (O) NHNH (Ph-4-CH_Three)
3,5- (CF_Three)₂             CF_Three          H H C (S) Et
3,5- (CF_Three)₂             CF_Three          H H C (S) Pr-n
3,5- (CF_Three)₂             CF_Three          H H C (S) Pr-i
3,5- (CF_Three)₂             CF_Three          H H C (S) Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (S) Pr-c
3,5- (CF_Three)₂             CF_Three          H H C (S) Bu-i
3,5- (CF_Three)₂             CF_Three          H H C (S) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (S) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          CN H C (S) CH₂Pr-c
3,5- (CF_Three)₂             CF_Three          H H C (S) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (S) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CN H C (S) CH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (S) (E-6a)
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (S) (E-6a)
3,5- (CF_Three)₂             CF_Three          CN H C (S) (E-6a)
3,5- (CF_Three)₂             CF_Three          H H C (S) OCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (S) OEt
3,5- (CF_Three)₂             CF_Three          H H C (S) OPr-i
3,5- (CF_Three)₂             CF_Three          H H C (S) OBu-i
3,5- (CF_Three)₂             CF_Three          H H C (S) OBu-t
3,5- (CF_Three)₂             CF_Three          H H C (S) OCH₂CH₂Cl
3,5- (CF_Three)₂             CF_Three          H H C (S) OCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          H H C (S) OCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H H C (S) OPh
3,5- (CF_Three)₂             CF_Three          H H C (S) SCH_Three
3,5- (CF_Three)₂             CF_Three          H H C (S) SEt
3,5- (CF_Three)₂             CF_Three          H H C (S) NHEt
3,5- (CF_Three)₂             CF_Three          H H C (S) NHPr-c
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (S) NHPr-c
3,5- (CF_Three)₂             CF_Three          CN H C (S) NHPr-c
3,5- (CF_Three)₂             CF_Three          H H C (S) NHCH₂CF_Three
3,5- (CF_Three)₂             CF_Three          CH_Three        H C (S) NHCH₂C≡CH
3,5- (CF_Three)₂             CF_Three          H H SO₂CH_Three
3,5- (CF_Three)₂             CF_Three          H H SO₂Et
3,5- (CF_Three)₂             CF_Three          H H SO₂Pr-i
3,5- (CF_Three)₂             CF_Three          H H SO₂Ph
3,5- (CF_Three)₂             CF_Three          H H SO₂(Ph-2,4-F₂)
3,5- (CF_Three)₂             CF₂Cl H H C (O) Et
3,5- (CF_Three)₂             CF₂Cl H Et C (O) Et
3,5- (CF_Three)₂             CF₂Cl H CH₂C≡CH C (O) Et
3,5- (CF_Three)₂             CF₂Cl CH_Three        H C (O) Et
3,5- (CF_Three)₂             CF₂Cl H H C (O) Pr-n
3,5- (CF_Three)₂             CF₂Cl H Et C (O) Pr-n
3,5- (CF_Three)₂             CF₂Cl CH_Three        H C (O) Pr-n
3,5- (CF_Three)₂             CF₂Cl H H C (O) Pr-i
3,5- (CF_Three)₂             CF₂Cl CH_Three        H C (O) Pr-i
3,5- (CF_Three)₂             CF₂Cl H H C (O) Pr-c
3,5- (CF_Three)₂             CF₂Cl H Et C (O) Pr-c
3,5- (CF_Three)₂             CF₂Cl H CH₂Pr-c C (O) Pr-c
3,5- (CF_Three)₂             CF₂Cl H CH₂OCH_Three    C (O) Pr-c
3,5- (CF_Three)₂             CF₂Cl H CH₂C≡CH C (O) Pr-c
3,5- (CF_Three)₂             CF₂Cl CH_Three        H C (O) Pr-c
3,5- (CF_Three)₂             CF₂Cl CH_Three        Et C (O) Pr-c
3,5- (CF_Three)₂             CF₂Cl CH_Three        CH₂CN C (O) Pr-c
3,5- (CF_Three)₂             CF₂Cl CH_Three        CH₂C≡CH C (O) Pr-c
3,5- (CF_Three)₂             CF₂Cl H H C (O) Bu-i
3,5- (CF_Three)₂             CF₂Cl H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF₂Cl H Et C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF₂Cl CH_Three        H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF₂Cl H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF₂Cl CH_Three        H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF₂Cl H H C (O) (E-6a)
3,5- (CF_Three)₂             CF₂Cl CH_Three        H C (O) (E-6a)
3,5- (CF_Three)₂             CF₂Cl H H C (O) NHEt
3,5- (CF_Three)₂             CF₂Cl H H C (O) NHPr-c
3,5- (CF_Three)₂             CF₂Cl CH_Three        H C (O) NHPr-c
3,5- (CF_Three)₂             CF₂Cl CH_Three        H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂             CFCl₂        H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CCl_Three         H H C (O) (E-6a)
3,5- (CF_Three)₂             CF₂Br H H C (O) Et
3,5- (CF_Three)₂             CF₂Br H H C (O) Pr-n
3,5- (CF_Three)₂             CF₂Br H H C (O) Pr-c
3,5- (CF_Three)₂             CF₂Br H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF₂Br CH_Three        H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF₂Br H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF₂Br CH_Three        H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF₂Br H H C (O) (E-6a)
3,5- (CF_Three)₂             CF₂Br CH_Three        H C (O) (E-6a)
3,5- (CF_Three)₂             CF₂Br CH_Three        H C (O) NHPr-c
3,5- (CF_Three)₂             CFClBr H H C (O) Pr-n
3,5- (CF_Three)₂             CFBr₂        H H C (O) Pr-c
3,5- (CF_Three)₂             CF₂I H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF₂CHF₂      H H C (O) Et
3,5- (CF_Three)₂             CF₂CHF₂      H H C (O) Pr-n
3,5- (CF_Three)₂             CF₂CHF₂      H H C (O) Pr-c
3,5- (CF_Three)₂             CF₂CHF₂      H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF₂CHF₂      CH_Three        H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF₂CHF₂      H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF₂CHF₂      CH_Three        H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF₂CHF₂      H H C (O) (E-6a)
3,5- (CF_Three)₂             CF₂CHF₂      CH_Three        H C (O) (E-6a)
3,5- (CF_Three)₂             CF₂CHF₂      CH_Three        H C (O) NHPr-c
3,5- (CF_Three)₂             CF₂CF_Three       H H C (O) Et
3,5- (CF_Three)₂             CF₂CF_Three       H H C (O) Pr-n
3,5- (CF_Three)₂             CF₂CF_Three       H H C (O) Pr-c
3,5- (CF_Three)₂             CF₂CF_Three       H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF₂CF_Three       CH_Three        H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF₂CF_Three       H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF₂CF_Three       CH_Three        H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF₂CF_Three       H H C (O) (E-6a)
3,5- (CF_Three)₂             CF₂CF_Three       CH_Three        H C (O) (E-6a)
3,5- (CF_Three)₂             CF₂CF_Three       CH_Three        H C (O) NHPr-c
3,5- (CF_Three)₂             CF₂CF₂Cl H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CFClCF_Three      H H C (O) (E-6a)
3,5- (CF_Three)₂             CFClCF₂Cl H H C (O) Pr-n
3,5- (CF_Three)₂             CF₂CF₂Br H H C (O) Pr-c
3,5- (CF_Three)₂             CFBrCF_Three      H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF₂CHFCF_Three    H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF₂CF₂CF_Three    H H C (O) (E-6a)
3,5- (CF_Three)₂             CF (CF_Three)₂     H H C (O) Pr-n
3,5- (CF_Three)₂             CH₂OCH₂CF_Three       H H C (O) Pr-c
3,5- (CF_Three)₂             CH₂OCH (CF_Three)₂     H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CH₂SCF_Three      H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CH₂SCH₂CF_Three   H H C (O) (E-6a)
3,5- (CF_Three)₂             CF₂OCH_Three      H H C (O) Pr-n
3,5- (CF_Three)₂             CF₂SCH_Three      H H C (O) Pr-c
3,5- (CF_Three)₂             CF₂SEt H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF₂SPr-n H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             CF₂SPr-i H H C (O) (E-6a)
3,5- (CF_Three)₂             CF₂CN H H C (O) Pr-n
3,5- (CF_Three)₂             CF₂C (O) OCH_Three  H H C (O) Pr-c
3,5- (CF_Three)₂             CF₂C (O) NH₂   H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             CF₂C (S) NH₂   H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             T-8 H H C (O) (E-6a)
3,5- (CF_Three)₂             T-9 H H C (O) Pr-n
3,5- (CF_Three)₂             T-10 H H C (O) Pr-c
3,5- (CF_Three)₂             CN H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             Ph H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             Ph-2-F H H C (O) (E-6a)
3,5- (CF_Three)₂             Ph-3-F H H C (O) Pr-n
3,5- (CF_Three)₂             Ph-4-F H H C (O) Pr-c
3,5- (CF_Three)₂             D-1a H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             D-2a H H C (O) CH₂CF_Three
3,5- (CF_Three)₂             D-3a H H C (O) (E-6a)
3,5- (CF_Three)₂             D-4a H H C (O) Pr-n
3,5- (CF_Three)₂             D-52a H H C (O) Pr-c
3,5- (CF_Three)₂             D-53a H H C (O) CH₂Pr-c
3,5- (CF_Three)₂             D-54a H H C (O) CH₂CF_Three
3-Cl-5-CF₂CF_Three          CF_Three          H H C (O) Pr-n
3-Cl-5-CF₂CF_Three          CF_Three          H H C (O) Pr-c
3-Cl-5-CF₂CF_Three          CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-CF₂CF_Three          CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-CF₂CF_Three          CF_Three          H H C (O) (E-6a)
3-Br-5-CF₂CF_Three          CF_Three          H H C (O) Pr-n
3-Br-5-CF₂CF_Three          CF_Three          H H C (O) Pr-c
3-Br-5-CF₂CF_Three          CF_Three          H H C (O) CH₂Pr-c
3-Br-5-CF₂CF_Three          CF_Three          H H C (O) CH₂CF_Three
3-Br-5-CF₂CF_Three          CF_Three          H H C (O) (E-6a)
3-CH_Three-5-CF₂CF_Three         CF_Three          H H C (O) (E-6a)
3-Cl-5-CF₂CF₂CF_Three       CF_Three          H H C (O) Pr-n
3-Br-5-CF₂CF₂CF_Three       CF_Three          H H C (O) Pr-c
3-CH_Three-5-CF₂CF₂CF_Three      CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-CF (CF_Three)₂        CF_Three          H H C (O) CH₂CF_Three
3-Br-5-CF (CF_Three)₂        CF_Three          H H C (O) (E-6a)
3-CH_Three-5-CF (CF_Three)₂       CF_Three          H H C (O) Pr-n
3-Cl-5-CH₂OCH_Three         CF_Three          H H C (O) Pr-c
3-Cl-5-CH₂OCH₂CF_Three      CF_Three          H H C (O) CH₂Pr-c
3-CF_Three-5-CH₂SCH_Three        CF_Three          H H C (O) CH₂CF_Three
3-CF_Three-5-CH₂S (O) CH_Three     CF_Three          H H C (O) (E-6a)
3-CF_Three-5-CH₂SO₂CH_Three      CF_Three          H H C (O) Pr-n
3-Cl-5-C (CF_Three)₂OH CF_Three          H H C (O) Pr-c
3-Br-5-C (CF_Three)₂OH CF_Three          H H C (O) CH₂Pr-c
3-CH_Three-5-C (CF_Three)₂OH CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-C (CF_Three)₂OCH_Three     CF_Three          H H C (O) (E-6a)
3-Br-5-C (CF_Three)₂OCH_Three     CF_Three          H H C (O) Pr-n
3-CH_Three-5-C (CF_Three)₂OCH_Three    CF_Three          H H C (O) Pr-c
3-Cl-5-OCH_Three            CF_Three          H H C (O) CH₂Pr-c
3-Br-5-OCH_Three            CF_Three          H H C (O) CH₂CF_Three
3-CF_Three-5-OCH_Three           CF_Three          H H C (O) Et
3-CF_Three-5-OCH_Three           CF_Three          H H C (O) Pr-n
3-CF_Three-5-OCH_Three           CF_Three          H H C (O) Pr-c
3-CF_Three-5-OCH_Three           CF_Three          H H C (O) CH₂Pr-c
3-CF_Three-5-OCH_Three           CF_Three          CH_Three        H C (O) CH₂Pr-c
3-CF_Three-5-OCH_Three           CF_Three          H H C (O) CH₂CF_Three
3-CF_Three-5-OCH_Three           CF_Three          CH_Three        H C (O) CH₂CF_Three
3-CF_Three-5-OCH_Three           CF_Three          H H C (O) (E-6a)
3-CF_Three-5-OCH_Three           CF_Three          CH_Three        H C (O) (E-6a)
3-CF_Three-5-OCH_Three           CF_Three          CH_Three        H C (O) NHPr-c
3-CF_Three-5-OCH_Three           CF₂Cl H H C (O) (E-6a)
3-OCH₂O-4 CF_Three          H H C (O) Pr-n
3-F-4-OCHF₂            CF_Three          H H C (O) Pr-c
3-Cl-4-OCHF₂           CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-OCHF₂           CHF₂         H H C (O) Pr-n
3-Cl-5-OCHF₂           CHF₂         H H C (O) Pr-c
3-Cl-5-OCHF₂           CHF₂         H H C (O) CH₂Pr-c
3-Cl-5-OCHF₂           CHF₂         H H C (O) CH₂CF_Three
3-Cl-5-OCHF₂           CHF₂         H H C (O) (E-6a)
3-Cl-5-OCHF₂           CF_Three          H H C (O) Et
3-Cl-5-OCHF₂           CF_Three          H Et C (O) Et
3-Cl-5-OCHF₂           CF_Three          H CH₂C≡CH C (O) Et
3-Cl-5-OCHF₂           CF_Three          CH_Three        H C (O) Et
3-Cl-5-OCHF₂           CF_Three          H H C (O) Pr-n
3-Cl-5-OCHF₂           CF_Three          H Et C (O) Pr-n
3-Cl-5-OCHF₂           CF_Three          CH_Three        H C (O) Pr-n
3-Cl-5-OCHF₂           CF_Three          H H C (O) Pr-i
3-Cl-5-OCHF₂           CF_Three          CH_Three        H C (O) Pr-i
3-Cl-5-OCHF₂           CF_Three          H H C (O) Pr-c
3-Cl-5-OCHF₂           CF_Three          H Et C (O) Pr-c
3-Cl-5-OCHF₂           CF_Three          H CH₂Pr-c C (O) Pr-c
3-Cl-5-OCHF₂           CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-Cl-5-OCHF₂           CF_Three          H CH₂C≡CH C (O) Pr-c
3-Cl-5-OCHF₂           CF_Three          CH_Three        H C (O) Pr-c
3-Cl-5-OCHF₂           CF_Three          CH_Three        Et C (O) Pr-c
3-Cl-5-OCHF₂           CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-Cl-5-OCHF₂           CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-Cl-5-OCHF₂           CF_Three          H H C (O) Bu-i
3-Cl-5-OCHF₂           CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-OCHF₂           CF_Three          H Et C (O) CH₂Pr-c
3-Cl-5-OCHF₂           CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Cl-5-OCHF₂           CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-OCHF₂           CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Cl-5-OCHF₂           CF_Three          H H C (O) (E-6a)
3-Cl-5-OCHF₂           CF_Three          CH_Three        H C (O) (E-6a)
3-Cl-5-OCHF₂           CF_Three          H H C (O) NHEt
3-Cl-5-OCHF₂           CF_Three          H H C (O) NHPr-c
3-Cl-5-OCHF₂           CF_Three          CH_Three        H C (O) NHPr-c
3-Cl-5-OCHF₂           CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Cl-5-OCHF₂           CF₂Cl H H C (O) Et
3-Cl-5-OCHF₂           CF₂Cl H H C (O) Pr-n
3-Cl-5-OCHF₂           CF₂Cl H H C (O) Pr-c
3-Cl-5-OCHF₂           CF₂Cl H H C (O) CH₂Pr-c
3-Cl-5-OCHF₂           CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-Cl-5-OCHF₂           CF₂Cl H H C (O) CH₂CF_Three
3-Cl-5-OCHF₂           CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-Cl-5-OCHF₂           CF₂Cl H H C (O) (E-6a)
3-Cl-5-OCHF₂           CF₂Cl CH_Three        H C (O) (E-6a)
3-Cl-5-OCHF₂           CF₂Cl CH_Three        H C (O) NHPr-c
3-Cl-5-OCHF₂           CF₂Br H H C (O) CH₂CF_Three
3-Cl-5-OCHF₂           CF₂CHF₂      H H C (O) (E-6a)
3-Cl-5-OCHF₂           CF₂CF_Three       H H C (O) Pr-n
3-Br-4-OCHF₂           CF_Three          H H C (O) Pr-c
3-Br-5-OCHF₂           CHF₂         H H C (O) CH₂Pr-c
3-Br-5-OCHF₂           CF_Three          H H C (O) Et
3-Br-5-OCHF₂           CF_Three          H H C (O) Pr-n
3-Br-5-OCHF₂           CF_Three          H H C (O) Pr-i
3-Br-5-OCHF₂           CF_Three          H H C (O) Pr-c
3-Br-5-OCHF₂           CF_Three          CH_Three        H C (O) Pr-c
3-Br-5-OCHF₂           CF_Three          H H C (O) Bu-i
3-Br-5-OCHF₂           CF_Three          H H C (O) CH₂Pr-c
3-Br-5-OCHF₂           CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Br-5-OCHF₂           CF_Three          H H C (O) CH₂CF_Three
3-Br-5-OCHF₂           CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Br-5-OCHF₂           CF_Three          H H C (O) (E-6a)
3-Br-5-OCHF₂           CF_Three          CH_Three        H C (O) (E-6a)
3-Br-5-OCHF₂           CF_Three          H H C (O) NHPr-c
3-Br-5-OCHF₂           CF_Three          CH_Three        H C (O) NHPr-c
3-Br-5-OCHF₂           CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Br-5-OCHF₂           CF₂Cl H H C (O) Pr-n
3-Br-5-OCHF₂           CF₂Cl H H C (O) Pr-c
3-Br-5-OCHF₂           CF₂Cl H H C (O) CH₂Pr-c
3-Br-5-OCHF₂           CF₂Cl H H C (O) CH₂CF_Three
3-Br-5-OCHF₂           CF₂Cl H H C (O) (E-6a)
3-CH_Three-5-OCHF₂          CF_Three          H H C (O) CH₂CF_Three
3-CF_Three-5-OCHF₂          CHF₂         H H C (O) (E-6a)
3-CF_Three-5-OCHF₂          CF_Three          H H C (O) Et
3-CF_Three-5-OCHF₂          CF_Three          H H C (O) Pr-n
3-CF_Three-5-OCHF₂          CF_Three          H H C (O) Pr-i
3-CF_Three-5-OCHF₂          CF_Three          H H C (O) Pr-c
3-CF_Three-5-OCHF₂          CF_Three          CH_Three        H C (O) Pr-c
3-CF_Three-5-OCHF₂          CF_Three          H H C (O) Bu-i
3-CF_Three-5-OCHF₂          CF_Three          H H C (O) CH₂Pr-c
3-CF_Three-5-OCHF₂          CF_Three          CH_Three        H C (O) CH₂Pr-c
3-CF_Three-5-OCHF₂          CF_Three          H H C (O) CH₂CF_Three
3-CF_Three-5-OCHF₂          CF_Three          CH_Three        H C (O) CH₂CF_Three
3-CF_Three-5-OCHF₂          CF_Three          H H C (O) (E-6a)
3-CF_Three-5-OCHF₂          CF_Three          CH_Three        H C (O) (E-6a)
3-CF_Three-5-OCHF₂          CF_Three          H H C (O) NHPr-c
3-CF_Three-5-OCHF₂          CF_Three          CH_Three        H C (O) NHPr-c
3-CF_Three-5-OCHF₂          CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-CF_Three-5-OCHF₂          CF₂Cl H H C (O) Pr-n
3-CF_Three-5-OCHF₂          CF₂Cl H H C (O) Pr-c
3-CF_Three-5-OCHF₂          CF₂Cl H H C (O) CH₂Pr-c
3-CF_Three-5-OCHF₂          CF₂Cl H H C (O) CH₂CF_Three
3-CF_Three-5-OCHF₂          CF₂Cl H H C (O) (E-6a)
3-F-4-OCF_Three             CF_Three          H H C (O) Pr-n
3-Cl-4-OCF_Three            CF_Three          H H C (O) Pr-c
3-Cl-5-OCF_Three            CHF₂         H H C (O) Pr-n
3-Cl-5-OCF_Three            CHF₂         H H C (O) Pr-c
3-Cl-5-OCF_Three            CHF₂         H H C (O) CH₂Pr-c
3-Cl-5-OCF_Three            CHF₂         H H C (O) CH₂CF_Three
3-Cl-5-OCF_Three            CHF₂         H H C (O) (E-6a)
3-Cl-5-OCF_Three            CF_Three          H H C (O) Et
3-Cl-5-OCF_Three            CF_Three          H Et C (O) Et
3-Cl-5-OCF_Three            CF_Three          H CH₂C≡CH C (O) Et
3-Cl-5-OCF_Three            CF_Three          CH_Three        H C (O) Et
3-Cl-5-OCF_Three            CF_Three          H H C (O) Pr-n
3-Cl-5-OCF_Three            CF_Three          H Et C (O) Pr-n
3-Cl-5-OCF_Three            CF_Three          CH_Three        H C (O) Pr-n
3-Cl-5-OCF_Three            CF_Three          H H C (O) Pr-i
3-Cl-5-OCF_Three            CF_Three          CH_Three        H C (O) Pr-i
3-Cl-5-OCF_Three            CF_Three          H H C (O) Pr-c
3-Cl-5-OCF_Three            CF_Three          H Et C (O) Pr-c
3-Cl-5-OCF_Three            CF_Three          H CH₂Pr-c C (O) Pr-c
3-Cl-5-OCF_Three            CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-Cl-5-OCF_Three            CF_Three          H CH₂C≡CH C (O) Pr-c
3-Cl-5-OCF_Three            CF_Three          CH_Three        H C (O) Pr-c
3-Cl-5-OCF_Three            CF_Three          CH_Three        Et C (O) Pr-c
3-Cl-5-OCF_Three            CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-Cl-5-OCF_Three            CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-Cl-5-OCF_Three            CF_Three          H H C (O) Bu-i
3-Cl-5-OCF_Three            CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-OCF_Three            CF_Three          H Et C (O) CH₂Pr-c
3-Cl-5-OCF_Three            CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Cl-5-OCF_Three            CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-OCF_Three            CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Cl-5-OCF_Three            CF_Three          H H C (O) (E-6a)
3-Cl-5-OCF_Three            CF_Three          CH_Three        H C (O) (E-6a)
3-Cl-5-OCF_Three            CF_Three          H H C (O) NHEt
3-Cl-5-OCF_Three            CF_Three          H H C (O) NHPr-c
3-Cl-5-OCF_Three            CF_Three          CH_Three        H C (O) NHPr-c
3-Cl-5-OCF_Three            CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Cl-5-OCF_Three            CF₂Cl H H C (O) Et
3-Cl-5-OCF_Three            CF₂Cl H H C (O) Pr-n
3-Cl-5-OCF_Three            CF₂Cl H H C (O) Pr-c
3-Cl-5-OCF_Three            CF₂Cl H H C (O) CH₂Pr-c
3-Cl-5-OCF_Three            CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-Cl-5-OCF_Three            CF₂Cl H H C (O) CH₂CF_Three
3-Cl-5-OCF_Three            CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-Cl-5-OCF_Three            CF₂Cl H H C (O) (E-6a)
3-Cl-5-OCF_Three            CF₂Cl CH_Three        H C (O) (E-6a)
3-Cl-5-OCF_Three            CF₂Cl CH_Three        H C (O) NHPr-c
3-Cl-5-OCF_Three            CF₂Br H H C (O) CH₂Pr-c
3-Cl-5-OCF_Three            CF₂CHF₂      H H C (O) CH₂CF_Three
3-Cl-5-OCF_Three            CF₂CF_Three       H H C (O) (E-6a)
3-Br-4-OCF_Three            CF_Three          H H C (O) Pr-n
3-Br-5-OCF_Three            CHF₂         H H C (O) Pr-c
3-Br-5-OCF_Three            CF_Three          H H C (O) Et
3-Br-5-OCF_Three            CF_Three          H H C (O) Pr-n
3-Br-5-OCF_Three            CF_Three          H H C (O) Pr-i
3-Br-5-OCF_Three            CF_Three          H H C (O) Pr-c
3-Br-5-OCF_Three            CF_Three          CH_Three        H C (O) Pr-c
3-Br-5-OCF_Three            CF_Three          H H C (O) Bu-i
3-Br-5-OCF_Three            CF_Three          H H C (O) CH₂Pr-c
3-Br-5-OCF_Three            CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Br-5-OCF_Three            CF_Three          H H C (O) CH₂CF_Three
3-Br-5-OCF_Three            CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Br-5-OCF_Three            CF_Three          H H C (O) (E-6a)
3-Br-5-OCF_Three            CF_Three          CH_Three        H C (O) (E-6a)
3-Br-5-OCF_Three            CF_Three          H H C (O) NHPr-c
3-Br-5-OCF_Three            CF_Three          CH_Three        H C (O) NHPr-c
3-Br-5-OCF_Three            CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Br-5-OCF_Three            CF₂Cl H H C (O) Pr-n
3-Br-5-OCF_Three            CF₂Cl H H C (O) Pr-c
3-Br-5-OCF_Three            CF₂Cl H H C (O) CH₂Pr-c
3-Br-5-OCF_Three            CF₂Cl H H C (O) CH₂CF_Three
3-Br-5-OCF_Three            CF₂Cl H H C (O) (E-6a)
3-CH_Three-5-OCF_Three           CF_Three          H H C (O) CH₂Pr-c
3-CF_Three-5-OCF_Three           CHF₂         H H C (O) CH₂CF_Three
3-CF_Three-5-OCF_Three           CF_Three          H H C (O) Et
3-CF_Three-5-OCF_Three           CF_Three          H H C (O) Pr-n
3-CF_Three-5-OCF_Three           CF_Three          H H C (O) Pr-i
3-CF_Three-5-OCF_Three           CF_Three          H H C (O) Pr-c
3-CF_Three-5-OCF_Three           CF_Three          CH_Three        H C (O) Pr-c
3-CF_Three-5-OCF_Three           CF_Three          H H C (O) Bu-i
3-CF_Three-5-OCF_Three           CF_Three          H H C (O) CH₂Pr-c
3-CF_Three-5-OCF_Three           CF_Three          CH_Three        H C (O) CH₂Pr-c
3-CF_Three-5-OCF_Three           CF_Three          H H C (O) CH₂CF_Three
3-CF_Three-5-OCF_Three           CF_Three          CH_Three        H C (O) CH₂CF_Three
3-CF_Three-5-OCF_Three           CF_Three          H H C (O) (E-6a)
3-CF_Three-5-OCF_Three           CF_Three          CH_Three        H C (O) (E-6a)
3-CF_Three-5-OCF_Three           CF_Three          H H C (O) NHPr-c
3-CF_Three-5-OCF_Three           CF_Three          CH_Three        H C (O) NHPr-c
3-CF_Three-5-OCF_Three           CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-CF_Three-5-OCF_Three           CF₂Cl H H C (O) Pr-n
3-CF_Three-5-OCF_Three           CF₂Cl H H C (O) Pr-c
3-CF_Three-5-OCF_Three           CF₂Cl H H C (O) CH₂Pr-c
3-CF_Three-5-OCF_Three           CF₂Cl H H C (O) CH₂CF_Three
3-CF_Three-5-OCF_Three           CF₂Cl H H C (O) (E-6a)
3-F-5-OCF₂Br CF_Three          H H C (O) (E-6a)
3-Cl-5-OCF₂Br CF_Three          H H C (O) Pr-n
3-CH_Three-5-OCF₂Br CF_Three          H H C (O) Pr-c
3-F-5-OCF₂CHF₂         CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-OCF₂CHF₂        CF_Three          H H C (O) CH₂CF_Three
3-CH_Three-5-OCF₂CHF₂       CF_Three          H H C (O) (E-6a)
3-F-5-OCF₂CHFCl CF_Three          H H C (O) Pr-n
3-Cl-5-OCF₂CHFCl CF_Three          H H C (O) Pr-c
3-Br-5-OCF₂CHFCl CF_Three          H H C (O) CH₂Pr-c
3-F-5-OCF₂CHFCF_Three       CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-OCF₂CHFCF_Three      CF_Three          H H C (O) (E-6a)
3-CH_Three-5-OCF₂CHFCF_Three     CF_Three          H H C (O) Pr-n
3-F-5-OCF₂CHFOCF_Three      CF_Three          H H C (O) Pr-c
3-Cl-5-OCF₂CHFOCF_Three     CF_Three          H H C (O) CH₂Pr-c
3-CH_Three-5-OCF₂CHFOCF_Three    CF_Three          H H C (O) CH₂CF_Three
3-CF₂OCF₂O-4 CF_Three          H H C (O) (E-6a)
3-OCF₂O-4 CF_Three          H H C (O) Pr-n
3-OCF₂CF₂O-4 CF_Three          H H C (O) Pr-c
3-F-5-SCH_Three             CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-SCH_Three            CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-S (O) CH_Three         CF_Three          H H C (O) (E-6a)
3-Cl-5-SO₂CH_Three          CF_Three          H H C (O) Pr-n
3-Br-5-SCH_Three            CF_Three          H H C (O) Pr-c
3-Br-5-S (O) CH_Three         CF_Three          H H C (O) CH₂Pr-c
3-Br-5-SO₂CH_Three          CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-SCF_Three            CHF₂         H H C (O) Pr-n
3-Cl-5-SCF_Three            CHF₂         H H C (O) Pr-c
3-Cl-5-SCF_Three            CHF₂         H H C (O) CH₂Pr-c
3-Cl-5-SCF_Three            CHF₂         H H C (O) CH₂CF_Three
3-Cl-5-SCF_Three            CHF₂         H H C (O) (E-6a)
3-Cl-5-SCF_Three            CF_Three          H H C (O) Et
3-Cl-5-SCF_Three            CF_Three          H Et C (O) Et
3-Cl-5-SCF_Three            CF_Three          H CH₂C≡CH C (O) Et
3-Cl-5-SCF_Three            CF_Three          CH_Three        H C (O) Et
3-Cl-5-SCF_Three            CF_Three          H H C (O) Pr-n
3-Cl-5-SCF_Three            CF_Three          H Et C (O) Pr-n
3-Cl-5-SCF_Three            CF_Three          CH_Three        H C (O) Pr-n
3-Cl-5-SCF_Three            CF_Three          H H C (O) Pr-i
3-Cl-5-SCF_Three            CF_Three          CH_Three        H C (O) Pr-i
3-Cl-5-SCF_Three            CF_Three          H H C (O) Pr-c
3-Cl-5-SCF_Three            CF_Three          H Et C (O) Pr-c
3-Cl-5-SCF_Three            CF_Three          H CH₂Pr-c C (O) Pr-c
3-Cl-5-SCF_Three            CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-Cl-5-SCF_Three            CF_Three          H CH₂C≡CH C (O) Pr-c
3-Cl-5-SCF_Three            CF_Three          CH_Three        H C (O) Pr-c
3-Cl-5-SCF_Three            CF_Three          CH_Three        Et C (O) Pr-c
3-Cl-5-SCF_Three            CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-Cl-5-SCF_Three            CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-Cl-5-SCF_Three            CF_Three          H H C (O) Bu-i
3-Cl-5-SCF_Three            CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-SCF_Three            CF_Three          H Et C (O) CH₂Pr-c
3-Cl-5-SCF_Three            CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Cl-5-SCF_Three            CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-SCF_Three            CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Cl-5-SCF_Three            CF_Three          H H C (O) (E-6a)
3-Cl-5-SCF_Three            CF_Three          CH_Three        H C (O) (E-6a)
3-Cl-5-SCF_Three            CF_Three          H H C (O) NHEt
3-Cl-5-SCF_Three            CF_Three          H H C (O) NHPr-c
3-Cl-5-SCF_Three            CF_Three          CH_Three        H C (O) NHPr-c
3-Cl-5-SCF_Three            CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Cl-5-SCF_Three            CF₂Cl H H C (O) Et
3-Cl-5-SCF_Three            CF₂Cl H H C (O) Pr-n
3-Cl-5-SCF_Three            CF₂Cl H H C (O) Pr-c
3-Cl-5-SCF_Three            CF₂Cl H H C (O) CH₂Pr-c
3-Cl-5-SCF_Three            CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-Cl-5-SCF_Three            CF₂Cl H H C (O) CH₂CF_Three
3-Cl-5-SCF_Three            CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-Cl-5-SCF_Three            CF₂Cl H H C (O) (E-6a)
3-Cl-5-SCF_Three            CF₂Cl CH_Three        H C (O) (E-6a)
3-Cl-5-SCF_Three            CF₂Cl CH_Three        H C (O) NHPr-c
3-Cl-5-SCF_Three            CF₂Br H H C (O) (E-6a)
3-Cl-5-SCF_Three            CF₂CHF₂      H H C (O) Pr-n
3-Cl-5-SCF_Three            CF₂CF_Three       H H C (O) Pr-c
3-Cl-5-S (O) CF_Three         CF_Three          H H C (O) Pr-n
3-Cl-5-S (O) CF_Three         CF_Three          H H C (O) Pr-c
3-Cl-5-S (O) CF_Three         CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-S (O) CF_Three         CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-S (O) CF_Three         CF_Three          H H C (O) (E-6a)
3-Cl-5-SO₂CF_Three          CF_Three          H H C (O) Et
3-Cl-5-SO₂CF_Three          CF_Three          H H C (O) Pr-n
3-Cl-5-SO₂CF_Three          CF_Three          H H C (O) Pr-c
3-Cl-5-SO₂CF_Three          CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-SO₂CF_Three          CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Cl-5-SO₂CF_Three          CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-SO₂CF_Three          CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Cl-5-SO₂CF_Three          CF_Three          H H C (O) (E-6a)
3-Cl-5-SO₂CF_Three          CF_Three          CH_Three        H C (O) (E-6a)
3-Cl-5-SO₂CF_Three          CF_Three          CH_Three        H C (O) NHPr-c
3-Cl-5-SO₂CF_Three          CF₂Cl H H C (O) CH₂Pr-c
3-Br-5-SCF_Three            CHF₂         H H C (O) CH₂CF_Three
3-Br-5-SCF_Three            CF_Three          H H C (O) Et
3-Br-5-SCF_Three            CF_Three          H H C (O) Pr-n
3-Br-5-SCF_Three            CF_Three          H H C (O) Pr-i
3-Br-5-SCF_Three            CF_Three          H H C (O) Pr-c
3-Br-5-SCF_Three            CF_Three          CH_Three        H C (O) Pr-c
3-Br-5-SCF_Three            CF_Three          H H C (O) Bu-i
3-Br-5-SCF_Three            CF_Three          H H C (O) CH₂Pr-c
3-Br-5-SCF_Three            CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Br-5-SCF_Three            CF_Three          H H C (O) CH₂CF_Three
3-Br-5-SCF_Three            CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Br-5-SCF_Three            CF_Three          H H C (O) (E-6a)
3-Br-5-SCF_Three            CF_Three          CH_Three        H C (O) (E-6a)
3-Br-5-SCF_Three            CF_Three          H H C (O) NHPr-c
3-Br-5-SCF_Three            CF_Three          CH_Three        H C (O) NHPr-c
3-Br-5-SCF_Three            CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Br-5-SCF_Three            CF₂Cl H H C (O) Pr-n
3-Br-5-SCF_Three            CF₂Cl H H C (O) Pr-c
3-Br-5-SCF_Three            CF₂Cl H H C (O) CH₂Pr-c
3-Br-5-SCF_Three            CF₂Cl H H C (O) CH₂CF_Three
3-Br-5-SCF_Three            CF₂Cl H H C (O) (E-6a)
3-Br-5-S (O) CF_Three         CF_Three          H H C (O) Pr-n
3-Br-5-S (O) CF_Three         CF_Three          H H C (O) Pr-c
3-Br-5-S (O) CF_Three         CF_Three          H H C (O) CH₂Pr-c
3-Br-5-S (O) CF_Three         CF_Three          H H C (O) CH₂CF_Three
3-Br-5-S (O) CF_Three         CF_Three          H H C (O) (E-6a)
3-Br-5-SO₂CF_Three          CF_Three          H H C (O) Et
3-Br-5-SO₂CF_Three          CF_Three          H H C (O) Pr-n
3-Br-5-SO₂CF_Three          CF_Three          H H C (O) Pr-c
3-Br-5-SO₂CF_Three          CF_Three          H H C (O) CH₂Pr-c
3-Br-5-SO₂CF_Three          CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Br-5-SO₂CF_Three          CF_Three          H H C (O) CH₂CF_Three
3-Br-5-SO₂CF_Three          CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Br-5-SO₂CF_Three          CF_Three          H H C (O) (E-6a)
3-Br-5-SO₂CF_Three          CF_Three          CH_Three        H C (O) (E-6a)
3-Br-5-SO₂CF_Three          CF_Three          CH_Three        H C (O) NHPr-c
3-Br-5-SO₂CF_Three          CF₂Cl H H C (O) (E-6a)
3-Cl-5-SCF₂CHFCl CF_Three          H H C (O) Pr-n
3-Cl-5-SCF₂CHFCl CF_Three          H H C (O) Pr-c
3-Cl-5-SCF₂CHFCl CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-SCF₂CHFCl CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-SCF₂CHFCl CF_Three          H H C (O) (E-6a)
3-Cl-5-S (O) CF₂CHFCl CF_Three          H H C (O) Pr-n
3-Cl-5-SO₂CF₂CHFCl CF_Three          H H C (O) Pr-c
3-Br-5-SCF₂CHFCl CF_Three          H H C (O) Pr-n
3-Br-5-SCF₂CHFCl CF_Three          H H C (O) Pr-c
3-Br-5-SCF₂CHFCl CF_Three          H H C (O) CH₂Pr-c
3-Br-5-SCF₂CHFCl CF_Three          H H C (O) CH₂CF_Three
3-Br-5-SCF₂CHFCl CF_Three          H H C (O) (E-6a)
3-Br-5-S (O) CF₂CHFCl CF_Three          H H C (O) CH₂Pr-c
3-Br-5-SO₂CF₂CHFCl CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-SPh CF_Three          H H C (O) (E-6a)
3-NO₂-4-F CF_Three          H H C (O) Pr-n
3-F-5-NO₂              CF_Three          H H C (O) Pr-c
3-NO₂-4-Cl CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-NO₂             CF_Three          H H C (O) Pr-n
3-Cl-5-NO₂             CF_Three          H H C (O) Pr-c
3-Cl-5-NO₂             CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-NO₂             CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-NO₂             CF_Three          H H C (O) (E-6a)
3-Br-5-NO₂             CF_Three          H H C (O) Pr-n
3-Br-5-NO₂             CF_Three          H H C (O) Pr-c
3-Br-5-NO₂             CF_Three          H H C (O) CH₂Pr-c
3-Br-5-NO₂             CF_Three          H H C (O) CH₂CF_Three
3-Br-5-NO₂             CF_Three          H H C (O) (E-6a)
3-CH_Three-5-NO₂            CF_Three          H H C (O) CH₂CF_Three
3-CF_Three-4-NO₂            CF_Three          H H C (O) (E-6a)
3-CF_Three-5-NO₂            CF_Three          H H C (O) Et
3-CF_Three-5-NO₂            CF_Three          H H C (O) Pr-n
3-CF_Three-5-NO₂            CF_Three          H H C (O) Pr-c
3-CF_Three-5-NO₂            CF_Three          H H C (O) CH₂Pr-c
3-CF_Three-5-NO₂            CF_Three          CH_Three        H C (O) CH₂Pr-c
3-CF_Three-5-NO₂            CF_Three          H H C (O) CH₂CF_Three
3-CF_Three-5-NO₂            CF_Three          CH_Three        H C (O) CH₂CF_Three
3-CF_Three-5-NO₂            CF_Three          H H C (O) (E-6a)
3-CF_Three-5-NO₂            CF_Three          CH_Three        H C (O) (E-6a)
3-CF_Three-5-NO₂            CF_Three          CH_Three        H C (O) NHPr-c
3-CF_Three-5-NO₂            CF₂Cl H H C (O) Pr-n
3,5- (NO₂)₂             CF_Three          H H C (O) Pr-c
3-Cl-5-NHC (O) CF_Three       CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-N (CH_Three) C (O) CF_Three   CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-N (CH_Three) SO₂CF_Three    CF_Three          H H C (O) (E-6a)
3-CF_Three-5-NHC (O) CH_Three      CF_Three          H H C (O) Pr-n
3-CF_Three-5-N (CH_Three) C (O) CH_Three  CF_Three          H H C (O) Pr-c
3-CF_Three-5-NHC (O) CF_Three      CF_Three          H H C (O) CH₂Pr-c
3-CF_Three-5-N (CH_Three) C (O) CF_Three  CF_Three          H H C (O) CH₂CF_Three
3-CF_Three-5-N (CH_Three) SO₂CF_Three   CF_Three          H H C (O) (E-6a)
3-CN-4-F CF_Three          H H C (O) Pr-n
3-F-4-CN CF_Three          H H C (O) Pr-c
3-F-5-CN CF_Three          H H C (O) CH₂Pr-c
3-Cl-4-CN CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-CN CF_Three          H H C (O) Et
3-Cl-5-CN CF_Three          H H C (O) Pr-n
3-Cl-5-CN CF_Three          H H C (O) Pr-c
3-Cl-5-CN CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-CN CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Cl-5-CN CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-CN CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Cl-5-CN CF_Three          H H C (O) (E-6a)
3-Cl-5-CN CF_Three          CH_Three        H C (O) (E-6a)
3-Cl-5-CN CF_Three          CH_Three        H C (O) NHPr-c
3-Cl-5-CN CF₂Cl H H C (O) (E-6a)
3-Br-5-CN CF_Three          H H C (O) Et
3-Br-5-CN CF_Three          H H C (O) Pr-n
3-Br-5-CN CF_Three          H H C (O) Pr-c
3-Br-5-CN CF_Three          H H C (O) CH₂Pr-c
3-Br-5-CN CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Br-5-CN CF_Three          H H C (O) CH₂CF_Three
3-Br-5-CN CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Br-5-CN CF_Three          H H C (O) (E-6a)
3-Br-5-CN CF_Three          CH_Three        H C (O) (E-6a)
3-Br-5-CN CF_Three          CH_Three        H C (O) NHPr-c
3-Br-5-CN CF₂Cl H H C (O) Pr-n
3-CH_Three-5-CN CF_Three          H H C (O) Pr-c
3-CF_Three-5-CN CHF₂         H H C (O) CH₂Pr-c
3-CF_Three-5-CN CF_Three          H H C (O) Et
3-CF_Three-5-CN CF_Three          H H C (O) Pr-n
3-CF_Three-5-CN CF_Three          H H C (O) Pr-i
3-CF_Three-5-CN CF_Three          H H C (O) Pr-c
3-CF_Three-5-CN CF_Three          CH_Three        H C (O) Pr-c
3-CF_Three-5-CN CF_Three          H H C (O) Bu-i
3-CF_Three-5-CN CF_Three          H H C (O) CH₂Pr-c
3-CF_Three-5-CN CF_Three          CH_Three        H C (O) CH₂Pr-c
3-CF_Three-5-CN CF_Three          H H C (O) CH₂CF_Three
3-CF_Three-5-CN CF_Three          CH_Three        H C (O) CH₂CF_Three
3-CF_Three-5-CN CF_Three          H H C (O) (E-6a)
3-CF_Three-5-CN CF_Three          CH_Three        H C (O) (E-6a)
3-CF_Three-5-CN CF_Three          H H C (O) NHPr-c
3-CF_Three-5-CN CF_Three          CH_Three        H C (O) NHPr-c
3-CF_Three-5-CN CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-CF_Three-5-CN CF₂Cl H H C (O) Pr-n
3-CF_Three-5-CN CF₂Cl H H C (O) Pr-c
3-CF_Three-5-CN CF₂Cl H H C (O) CH₂Pr-c
3-CF_Three-5-CN CF₂Cl H H C (O) CH₂CF_Three
3-CF_Three-5-CN CF₂Cl H H C (O) (E-6a)
3-NO₂-5-CN CF_Three          H H C (O) CH₂CF_Three
3,5- (CN)₂              CF_Three          H H C (O) (E-6a)
3-Cl-5-C (O) OCH_Three        CF_Three          H H C (O) Pr-n
3-Br-5-C (O) OCH_Three        CF_Three          H H C (O) Pr-c
3-CF_Three-5-C (O) OCH_Three       CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-C (O) NH₂         CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-C (O) NHCH_Three       CF_Three          H H C (O) (E-6a)
3-Cl-5-C (O) N (CH_Three)₂     CF_Three          H H C (O) Pr-n
3-Br-5-C (O) NH₂         CF_Three          H H C (O) Pr-c
3-Br-5-C (O) NHCH_Three       CF_Three          H H C (O) CH₂Pr-c
3-Br-5-C (O) N (CH_Three)₂     CF_Three          H H C (O) CH₂CF_Three
3-CF_Three-5-C (O) NH₂        CF_Three          H H C (O) (E-6a)
3-CF_Three-5-C (O) NHCH_Three      CF_Three          H H C (O) Pr-n
3-CF_Three-5-C (O) N (CH_Three)₂    CF_Three          H H C (O) Pr-c
3-Cl-5-SO₂OCH_Three         CF_Three          H H C (O) CH₂Pr-c
3-Cl-5-SO₂NH₂          CF_Three          H H C (O) CH₂CF_Three
3-Cl-5-SO₂NHCH_Three        CF_Three          H H C (O) (E-6a)
3-Cl-5-SO₂N (CH_Three)₂      CF_Three          H H C (O) Pr-n
3,4,5-F_Three               CHF₂         H H C (O) Pr-c
3,4,5-F_Three               CF_Three          H H C (O) Et
3,4,5-F_Three               CF_Three          H H C (O) Pr-n
3,4,5-F_Three               CF_Three          H H C (O) Pr-i
3,4,5-F_Three               CF_Three          H H C (O) Pr-c
3,4,5-F_Three               CF_Three          CH_Three        H C (O) Pr-c
3,4,5-F_Three               CF_Three          H H C (O) Bu-i
3,4,5-F_Three               CF_Three          H H C (O) CH₂Pr-c
3,4,5-F_Three               CF_Three          CH_Three        H C (O) CH₂Pr-c
3,4,5-F_Three               CF_Three          H H C (O) CH₂CF_Three
3,4,5-F_Three               CF_Three          CH_Three        H C (O) CH₂CF_Three
3,4,5-F_Three               CF_Three          H H C (O) (E-6a)
3,4,5-F_Three               CF_Three          CH_Three        H C (O) (E-6a)
3,4,5-F_Three               CF_Three          H H C (O) NHPr-c
3,4,5-F_Three               CF_Three          CH_Three        H C (O) NHPr-c
3,4,5-F_Three               CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,4,5-F_Three               CF₂Cl H H C (O) Pr-n
3,4,5-F_Three               CF₂Cl H H C (O) Pr-c
3,4,5-F_Three               CF₂Cl H H C (O) CH₂Pr-c
3,4,5-F_Three               CF₂Cl H H C (O) CH₂CF_Three
3,4,5-F_Three               CF₂Cl H H C (O) (E-6a)
3,5-Cl₂-4-F CHF₂         H H C (O) Et
3,5-Cl₂-4-F CHF₂         H H C (O) Pr-n
3,5-Cl₂-4-F CHF₂         H H C (O) Pr-c
3,5-Cl₂-4-F CHF₂         H H C (O) CH₂Pr-c
3,5-Cl₂-4-F CHF₂         CH_Three        H C (O) CH₂Pr-c
3,5-Cl₂-4-F CHF₂         H H C (O) CH₂CF_Three
3,5-Cl₂-4-F CHF₂         CH_Three        H C (O) CH₂CF_Three
3,5-Cl₂-4-F CHF₂         H H C (O) (E-6a)
3,5-Cl₂-4-F CHF₂         CH_Three        H C (O) (E-6a)
3,5-Cl₂-4-F CHF₂         CH_Three        H C (O) NHPr-c
3,5-Cl₂-4-F CF_Three          H H H
3,5-Cl₂-4-F CF_Three          CH_Three        H H
3,5-Cl₂-4-F CF_Three          CN H H
3,5-Cl₂-4-F CF_Three          H H C (O) CH_Three
3,5-Cl₂-4-F CF_Three          H H C (O) Et
3,5-Cl₂-4-F CF_Three          H Et C (O) Et
3,5-Cl₂-4-F CF_Three          H CH₂Pr-c C (O) Et
3,5-Cl₂-4-F CF_Three          H CH₂OCH_Three    C (O) Et
3,5-Cl₂-4-F CF_Three          H CH₂CN C (O) Et
3,5-Cl₂-4-F CF_Three          H CH₂CH = CH₂  C (O) Et
3,5-Cl₂-4-F CF_Three          H CH₂C≡CH C (O) Et
3,5-Cl₂-4-F CF_Three          CH_Three        H C (O) Et
3,5-Cl₂-4-F CF_Three          CH_Three        Et C (O) Et
3,5-Cl₂-4-F CF_Three          CH_Three        CH₂Pr-c C (O) Et
3,5-Cl₂-4-F CF_Three          CH_Three        CH₂OCH_Three    C (O) Et
3,5-Cl₂-4-F CF_Three          CH_Three        CH₂CN C (O) Et
3,5-Cl₂-4-F CF_Three          CH_Three        CH₂C≡CH C (O) Et
3,5-Cl₂-4-F CF_Three          H H C (O) Pr-n
3,5-Cl₂-4-F CF_Three          H Et C (O) Pr-n
3,5-Cl₂-4-F CF_Three          H CH₂Pr-c C (O) Pr-n
3,5-Cl₂-4-F CF_Three          H CH₂OCH_Three    C (O) Pr-n
3,5-Cl₂-4-F CF_Three          H CH₂CN C (O) Pr-n
3,5-Cl₂-4-F CF_Three          H CH₂C≡CH C (O) Pr-n
3,5-Cl₂-4-F CF_Three          CH_Three        H C (O) Pr-n
3,5-Cl₂-4-F CF_Three          CF_Three        H C (O) Pr-n
3,5-Cl₂-4-F CF_Three          CN H C (O) Pr-n
3,5-Cl₂-4-F CF_Three          C≡CH H C (O) Pr-n
3,5-Cl₂-4-F CF_Three          H H C (O) Pr-i
3,5-Cl₂-4-F CF_Three          CH_Three        H C (O) Pr-i
3,5-Cl₂-4-F CF_Three          H H C (O) Pr-c
3,5-Cl₂-4-F CF_Three          H CH_Three        C (O) Pr-c
3,5-Cl₂-4-F CF_Three          H Et C (O) Pr-c
3,5-Cl₂-4-F CF_Three          H n-Pr C (O) Pr-c
3,5-Cl₂-4-F CF_Three          H CH₂Pr-c C (O) Pr-c
3,5-Cl₂-4-F CF_Three          H CH₂OCH_Three    C (O) Pr-c
3,5-Cl₂-4-F CF_Three          H CH₂CN C (O) Pr-c
3,5-Cl₂-4-F CF_Three          H CH₂CH = CH₂  C (O) Pr-c
3,5-Cl₂-4-F CF_Three          H CH₂C≡CH C (O) Pr-c
3,5-Cl₂-4-F CF_Three          CH_Three        H C (O) Pr-c
3,5-Cl₂-4-F CF_Three          CH_Three        Et C (O) Pr-c
3,5-Cl₂-4-F CF_Three          CH_Three        CH₂Pr-c C (O) Pr-c
3,5-Cl₂-4-F CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-c
3,5-Cl₂-4-F CF_Three          CH_Three        CH₂CN C (O) Pr-c
3,5-Cl₂-4-F CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3,5-Cl₂-4-F CF_Three          CF_Three        H C (O) Pr-c
3,5-Cl₂-4-F CF_Three          CN H C (O) Pr-c
3,5-Cl₂-4-F CF_Three          C≡CH H C (O) Pr-c
3,5-Cl₂-4-F CF_Three          H H C (O) Bu-i
3,5-Cl₂-4-F CF_Three          H H C (O) CH₂Pr-c
3,5-Cl₂-4-F CF_Three          H Et C (O) CH₂Pr-c
3,5-Cl₂-4-F CF_Three          H CH₂Pr-c C (O) CH₂Pr-c
3,5-Cl₂-4-F CF_Three          H CH₂OCH_Three    C (O) CH₂Pr-c
3,5-Cl₂-4-F CF_Three          H CH₂CN C (O) CH₂Pr-c
3,5-Cl₂-4-F CF_Three          H CH₂CH = CH₂  C (O) CH₂Pr-c
3,5-Cl₂-4-F CF_Three          H CH₂C≡CH C (O) CH₂Pr-c
3,5-Cl₂-4-F CF_Three          CH_Three        H C (O) CH₂Pr-c
3,5-Cl₂-4-F CF_Three          CF_Three        H C (O) CH₂Pr-c
3,5-Cl₂-4-F CF_Three          CN H C (O) CH₂Pr-c
3,5-Cl₂-4-F CF_Three          C≡CH H C (O) CH₂Pr-c
3,5-Cl₂-4-F CF_Three          H H C (O) (T-1)
3,5-Cl₂-4-F CF_Three          CH_Three        H C (O) (T-1)
3,5-Cl₂-4-F CF_Three          H H C (O) Bu-c
3,5-Cl₂-4-F CF_Three          H H C (O) CH₂CF_Three
3,5-Cl₂-4-F CF_Three          H Et C (O) CH₂CF_Three
3,5-Cl₂-4-F CF_Three          H CH₂Pr-c C (O) CH₂CF_Three
3,5-Cl₂-4-F CF_Three          H CH₂OCH_Three    C (O) CH₂CF_Three
3,5-Cl₂-4-F CF_Three          H CH₂CN C (O) CH₂CF_Three
3,5-Cl₂-4-F CF_Three          H CH₂C≡CH C (O) CH₂CF_Three
3,5-Cl₂-4-F CF_Three          CH_Three        H C (O) CH₂CF_Three
3,5-Cl₂-4-F CF_Three          CF_Three        H C (O) CH₂CF_Three
3,5-Cl₂-4-F CF_Three          CN H C (O) CH₂CF_Three
3,5-Cl₂-4-F CF_Three          C≡CH H C (O) CH₂CF_Three
3,5-Cl₂-4-F CF_Three          H H C (O) CH₂CH₂CF_Three
3,5-Cl₂-4-F CF_Three          H H C (O) (E-6a)
3,5-Cl₂-4-F CF_Three          H Et C (O) (E-6a)
3,5-Cl₂-4-F CF_Three          H CH₂Pr-c C (O) (E-6a)
3,5-Cl₂-4-F CF_Three          H CH₂OCH_Three    C (O) (E-6a)
3,5-Cl₂-4-F CF_Three          H CH₂CN C (O) (E-6a)
3,5-Cl₂-4-F CF_Three          H CH₂C≡CH C (O) (E-6a)
3,5-Cl₂-4-F CF_Three          CH_Three        H C (O) (E-6a)
3,5-Cl₂-4-F CF_Three          CF_Three        H C (O) (E-6a)
3,5-Cl₂-4-F CF_Three          CN H C (O) (E-6a)
3,5-Cl₂-4-F CF_Three          C≡CH H C (O) (E-6a)
3,5-Cl₂-4-F CF_Three          H H C (O) CH₂CH₂C≡CH
3,5-Cl₂-4-F CF_Three          H H C (O) NHEt
3,5-Cl₂-4-F CF_Three          H CH₂CH = CH₂  C (O) NHEt
3,5-Cl₂-4-F CF_Three          H CH₂C≡CH C (O) NHEt
3,5-Cl₂-4-F CF_Three          CH_Three        H C (O) NHEt
3,5-Cl₂-4-F CF_Three          H H C (O) NHPr-c
3,5-Cl₂-4-F CF_Three          CH_Three        H C (O) NHPr-c
3,5-Cl₂-4-F CF_Three          H H C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF_Three          CH_Three        H C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,5-Cl₂-4-F CF_Three          H H C (O) (T-23)
3,5-Cl₂-4-F CF_Three          H H C (O) (T-33)
3,5-Cl₂-4-F CF_Three          H H C (S) CH₂Pr-c
3,5-Cl₂-4-F CF_Three          CH_Three        H C (S) CH₂Pr-c
3,5-Cl₂-4-F CF₂Cl H H C (O) Et
3,5-Cl₂-4-F CF₂Cl H H C (O) Pr-n
3,5-Cl₂-4-F CF₂Cl H H C (O) Pr-i
3,5-Cl₂-4-F CF₂Cl H H C (O) Pr-c
3,5-Cl₂-4-F CF₂Cl CH_Three        H C (O) Pr-c
3,5-Cl₂-4-F CF₂Cl H H C (O) Bu-i
3,5-Cl₂-4-F CF₂Cl H H C (O) CH₂Pr-c
3,5-Cl₂-4-F CF₂Cl CH_Three        H C (O) CH₂Pr-c
3,5-Cl₂-4-F CF₂Cl H H C (O) CH₂CF_Three
3,5-Cl₂-4-F CF₂Cl CH_Three        H C (O) CH₂CF_Three
3,5-Cl₂-4-F CF₂Cl H H C (O) (E-6a)
3,5-Cl₂-4-F CF₂Cl CH_Three        H C (O) (E-6a)
3,5-Cl₂-4-F CF₂Cl H H C (O) NHPr-c
3,5-Cl₂-4-F CF₂Cl CH_Three        H C (O) NHPr-c
3,5-Cl₂-4-F CF₂Cl CH_Three        H C (O) NHCH₂C≡CH
3,5-Cl₂-4-F CF₂Br H H C (O) Pr-n
3,5-Cl₂-4-F CF₂Br H H C (O) Pr-c
3,5-Cl₂-4-F CF₂Br H H C (O) CH₂Pr-c
3,5-Cl₂-4-F CF₂Br H H C (O) CH₂CF_Three
3,5-Cl₂-4-F CF₂Br H H C (O) (E-6a)
3,5-Cl₂-4-F CF₂CHF₂      H H C (O) Pr-n
3,5-Cl₂-4-F CF₂CHF₂      H H C (O) Pr-c
3,5-Cl₂-4-F CF₂CHF₂      H H C (O) CH₂Pr-c
3,5-Cl₂-4-F CF₂CHF₂      H H C (O) CH₂CF_Three
3,5-Cl₂-4-F CF₂CHF₂      H H C (O) (E-6a)
3,5-Cl₂-4-F CF₂CF_Three       H H C (O) Pr-n
3,5-Cl₂-4-F CF₂CF_Three       H H C (O) Pr-c
3,5-Cl₂-4-F CF₂CF_Three       H H C (O) CH₂Pr-c
3,5-Cl₂-4-F CF₂CF_Three       H H C (O) CH₂CF_Three
3,5-Cl₂-4-F CF₂CF_Three       H H C (O) (E-6a)
3,4,5-Cl_Three              CHF₂         H H C (O) Et
3,4,5-Cl_Three              CHF₂         H H C (O) Pr-n
3,4,5-Cl_Three              CHF₂         H H C (O) Pr-c
3,4,5-Cl_Three              CHF₂         H H C (O) CH₂Pr-c
3,4,5-Cl_Three              CHF₂         CH_Three        H C (O) CH₂Pr-c
3,4,5-Cl_Three              CHF₂         H H C (O) CH₂CF_Three
3,4,5-Cl_Three              CHF₂         CH_Three        H C (O) CH₂CF_Three
3,4,5-Cl_Three              CHF₂         H H C (O) (E-6a)
3,4,5-Cl_Three              CHF₂         CH_Three        H C (O) (E-6a)
3,4,5-Cl_Three              CHF₂         CH_Three        H C (O) NHPr-c
3,4,5-Cl_Three              CF_Three          H H H
3,4,5-Cl_Three              CF_Three          CH_Three        H H
3,4,5-Cl_Three              CF_Three          CN H H
3,4,5-Cl_Three              CF_Three          H H C (O) CH_Three
3,4,5-Cl_Three              CF_Three          H H C (O) Et
3,4,5-Cl_Three              CF_Three          H Et C (O) Et
3,4,5-Cl_Three              CF_Three          H CH₂Pr-c C (O) Et
3,4,5-Cl_Three              CF_Three          H CH₂OCH_Three    C (O) Et
3,4,5-Cl_Three              CF_Three          H CH₂CN C (O) Et
3,4,5-Cl_Three              CF_Three          H CH₂CH = CH₂  C (O) Et
3,4,5-Cl_Three              CF_Three          H CH₂C≡CH C (O) Et
3,4,5-Cl_Three              CF_Three          CH_Three        H C (O) Et
3,4,5-Cl_Three              CF_Three          CH_Three        Et C (O) Et
3,4,5-Cl_Three              CF_Three          CH_Three        CH₂Pr-c C (O) Et
3,4,5-Cl_Three              CF_Three          CH_Three        CH₂OCH_Three    C (O) Et
3,4,5-Cl_Three              CF_Three          CH_Three        CH₂CN C (O) Et
3,4,5-Cl_Three              CF_Three          CH_Three        CH₂C≡CH C (O) Et
3,4,5-Cl_Three              CF_Three          H H C (O) Pr-n
3,4,5-Cl_Three              CF_Three          H Et C (O) Pr-n
3,4,5-Cl_Three              CF_Three          H CH₂Pr-c C (O) Pr-n
3,4,5-Cl_Three              CF_Three          H CH₂OCH_Three    C (O) Pr-n
3,4,5-Cl_Three              CF_Three          H CH₂CN C (O) Pr-n
3,4,5-Cl_Three              CF_Three          H CH₂C≡CH C (O) Pr-n
3,4,5-Cl_Three              CF_Three          CH_Three        H C (O) Pr-n
3,4,5-Cl_Three              CF_Three          CF_Three        H C (O) Pr-n
3,4,5-Cl_Three              CF_Three          CN H C (O) Pr-n
3,4,5-Cl_Three              CF_Three          C≡CH H C (O) Pr-n
3,4,5-Cl_Three              CF_Three          H H C (O) Pr-i
3,4,5-Cl_Three              CF_Three          CH_Three        H C (O) Pr-i
3,4,5-Cl_Three              CF_Three          H H C (O) Pr-c
3,4,5-Cl_Three              CF_Three          H CH_Three        C (O) Pr-c
3,4,5-Cl_Three              CF_Three          H Et C (O) Pr-c
3,4,5-Cl_Three              CF_Three          H n-Pr C (O) Pr-c
3,4,5-Cl_Three              CF_Three          H CH₂Pr-c C (O) Pr-c
3,4,5-Cl_Three              CF_Three          H CH₂OCH_Three    C (O) Pr-c
3,4,5-Cl_Three              CF_Three          H CH₂CN C (O) Pr-c
3,4,5-Cl_Three              CF_Three          H CH₂CH = CH₂  C (O) Pr-c
3,4,5-Cl_Three              CF_Three          H CH₂C≡CH C (O) Pr-c
3,4,5-Cl_Three              CF_Three          CH_Three        H C (O) Pr-c
3,4,5-Cl_Three              CF_Three          CH_Three        Et C (O) Pr-c
3,4,5-Cl_Three              CF_Three          CH_Three        CH₂Pr-c C (O) Pr-c
3,4,5-Cl_Three              CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-c
3,4,5-Cl_Three              CF_Three          CH_Three        CH₂CN C (O) Pr-c
3,4,5-Cl_Three              CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3,4,5-Cl_Three              CF_Three          CF_Three        H C (O) Pr-c
3,4,5-Cl_Three              CF_Three          CN H C (O) Pr-c
3,4,5-Cl_Three              CF_Three          C≡CH H C (O) Pr-c
3,4,5-Cl_Three              CF_Three          H H C (O) Bu-i
3,4,5-Cl_Three              CF_Three          H H C (O) CH₂Pr-c
3,4,5-Cl_Three              CF_Three          H Et C (O) CH₂Pr-c
3,4,5-Cl_Three              CF_Three          H CH₂Pr-c C (O) CH₂Pr-c
3,4,5-Cl_Three              CF_Three          H CH₂OCH_Three    C (O) CH₂Pr-c
3,4,5-Cl_Three              CF_Three          H CH₂CN C (O) CH₂Pr-c
3,4,5-Cl_Three              CF_Three          H CH₂CH = CH₂  C (O) CH₂Pr-c
3,4,5-Cl_Three              CF_Three          H CH₂C≡CH C (O) CH₂Pr-c
3,4,5-Cl_Three              CF_Three          CH_Three        H C (O) CH₂Pr-c
3,4,5-Cl_Three              CF_Three          CF_Three        H C (O) CH₂Pr-c
3,4,5-Cl_Three              CF_Three          CN H C (O) CH₂Pr-c
3,4,5-Cl_Three              CF_Three          C≡CH H C (O) CH₂Pr-c
3,4,5-Cl_Three              CF_Three          H H C (O) (T-1)
3,4,5-Cl_Three              CF_Three          CH_Three        H C (O) (T-1)
3,4,5-Cl_Three              CF_Three          H H C (O) Bu-c
3,4,5-Cl_Three              CF_Three          H H C (O) CH₂CF_Three
3,4,5-Cl_Three              CF_Three          H Et C (O) CH₂CF_Three
3,4,5-Cl_Three              CF_Three          H CH₂Pr-c C (O) CH₂CF_Three
3,4,5-Cl_Three              CF_Three          H CH₂OCH_Three    C (O) CH₂CF_Three
3,4,5-Cl_Three              CF_Three          H CH₂CN C (O) CH₂CF_Three
3,4,5-Cl_Three              CF_Three          H CH₂C≡CH C (O) CH₂CF_Three
3,4,5-Cl_Three              CF_Three          CH_Three        H C (O) CH₂CF_Three
3,4,5-Cl_Three              CF_Three          CF_Three        H C (O) CH₂CF_Three
3,4,5-Cl_Three              CF_Three          CN H C (O) CH₂CF_Three
3,4,5-Cl_Three              CF_Three          C≡CH H C (O) CH₂CF_Three
3,4,5-Cl_Three              CF_Three          H H C (O) CH₂CH₂CF_Three
3,4,5-Cl_Three              CF_Three          H H C (O) (E-6a)
3,4,5-Cl_Three              CF_Three          H Et C (O) (E-6a)
3,4,5-Cl_Three              CF_Three          H CH₂Pr-c C (O) (E-6a)
3,4,5-Cl_Three              CF_Three          H CH₂OCH_Three    C (O) (E-6a)
3,4,5-Cl_Three              CF_Three          H CH₂CN C (O) (E-6a)
3,4,5-Cl_Three              CF_Three          H CH₂C≡CH C (O) (E-6a)
3,4,5-Cl_Three              CF_Three          CH_Three        H C (O) (E-6a)
3,4,5-Cl_Three              CF_Three          CF_Three        H C (O) (E-6a)
3,4,5-Cl_Three              CF_Three          CN H C (O) (E-6a)
3,4,5-Cl_Three              CF_Three          C≡CH H C (O) (E-6a)
3,4,5-Cl_Three              CF_Three          H H C (O) CH₂CH₂C≡CH
3,4,5-Cl_Three              CF_Three          H H C (O) NHEt
3,4,5-Cl_Three              CF_Three          H CH₂CH = CH₂  C (O) NHEt
3,4,5-Cl_Three              CF_Three          H CH₂C≡CH C (O) NHEt
3,4,5-Cl_Three              CF_Three          CH_Three        H C (O) NHEt
3,4,5-Cl_Three              CF_Three          H H C (O) NHPr-c
3,4,5-Cl_Three              CF_Three          CH_Three        H C (O) NHPr-c
3,4,5-Cl_Three              CF_Three          H H C (O) NHCH₂CF_Three
3,4,5-Cl_Three              CF_Three          CH_Three        H C (O) NHCH₂CF_Three
3,4,5-Cl_Three              CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,4,5-Cl_Three              CF_Three          H H C (O) (T-23)
3,4,5-Cl_Three              CF_Three          H H C (O) (T-33)
3,4,5-Cl_Three              CF_Three          H H C (S) CH₂Pr-c
3,4,5-Cl_Three              CF_Three          CH_Three        H C (S) CH₂Pr-c
3,4,5-Cl_Three              CF₂Cl H H C (O) Et
3,4,5-Cl_Three              CF₂Cl H H C (O) Pr-n
3,4,5-Cl_Three              CF₂Cl H H C (O) Pr-i
3,4,5-Cl_Three              CF₂Cl H H C (O) Pr-c
3,4,5-Cl_Three              CF₂Cl CH_Three        H C (O) Pr-c
3,4,5-Cl_Three              CF₂Cl H H C (O) Bu-i
3,4,5-Cl_Three              CF₂Cl H H C (O) CH₂Pr-c
3,4,5-Cl_Three              CF₂Cl CH_Three        H C (O) CH₂Pr-c
3,4,5-Cl_Three              CF₂Cl H H C (O) CH₂CF_Three
3,4,5-Cl_Three              CF₂Cl CH_Three        H C (O) CH₂CF_Three
3,4,5-Cl_Three              CF₂Cl H H C (O) (E-6a)
3,4,5-Cl_Three              CF₂Cl CH_Three        H C (O) (E-6a)
3,4,5-Cl_Three              CF₂Cl H H C (O) NHPr-c
3,4,5-Cl_Three              CF₂Cl CH_Three        H C (O) NHPr-c
3,4,5-Cl_Three              CF₂Cl CH_Three        H C (O) NHCH₂C≡CH
3,4,5-Cl_Three              CF₂Br H H C (O) Pr-n
3,4,5-Cl_Three              CF₂Br H H C (O) Pr-c
3,4,5-Cl_Three              CF₂Br H H C (O) CH₂Pr-c
3,4,5-Cl_Three              CF₂Br H H C (O) CH₂CF_Three
3,4,5-Cl_Three              CF₂Br H H C (O) (E-6a)
3,4,5-Cl_Three              CF₂CHF₂      H H C (O) Pr-n
3,4,5-Cl_Three              CF₂CHF₂      H H C (O) Pr-c
3,4,5-Cl_Three              CF₂CHF₂      H H C (O) CH₂Pr-c
3,4,5-Cl_Three              CF₂CHF₂      H H C (O) CH₂CF_Three
3,4,5-Cl_Three              CF₂CHF₂      H H C (O) (E-6a)
3,4,5-Cl_Three              CF₂CF_Three       H H C (O) Pr-n
3,4,5-Cl_Three              CF₂CF_Three       H H C (O) Pr-c
3,4,5-Cl_Three              CF₂CF_Three       H H C (O) CH₂Pr-c
3,4,5-Cl_Three              CF₂CF_Three       H H C (O) CH₂CF_Three
3,4,5-Cl_Three              CF₂CF_Three       H H C (O) (E-6a)
3,5-Br₂-4-F CHF₂         H H C (O) Et
3,5-Br₂-4-F CHF₂         H H C (O) Pr-n
3,5-Br₂-4-F CHF₂         H H C (O) Pr-c
3,5-Br₂-4-F CHF₂         H H C (O) CH₂Pr-c
3,5-Br₂-4-F CHF₂         CH_Three        H C (O) CH₂Pr-c
3,5-Br₂-4-F CHF₂         H H C (O) CH₂CF_Three
3,5-Br₂-4-F CHF₂         CH_Three        H C (O) CH₂CF_Three
3,5-Br₂-4-F CHF₂         H H C (O) (E-6a)
3,5-Br₂-4-F CHF₂         CH_Three        H C (O) (E-6a)
3,5-Br₂-4-F CHF₂         CH_Three        H C (O) NHPr-c
3,5-Br₂-4-F CF_Three          H H H
3,5-Br₂-4-F CF_Three          CH_Three        H H
3,5-Br₂-4-F CF_Three          CN H H
3,5-Br₂-4-F CF_Three          H H C (O) CH_Three
3,5-Br₂-4-F CF_Three          H H C (O) Et
3,5-Br₂-4-F CF_Three          H Et C (O) Et
3,5-Br₂-4-F CF_Three          H CH₂Pr-c C (O) Et
3,5-Br₂-4-F CF_Three          H CH₂OCH_Three    C (O) Et
3,5-Br₂-4-F CF_Three          H CH₂CN C (O) Et
3,5-Br₂-4-F CF_Three          H CH₂CH = CH₂  C (O) Et
3,5-Br₂-4-F CF_Three          H CH₂C≡CH C (O) Et
3,5-Br₂-4-F CF_Three          CH_Three        H C (O) Et
3,5-Br₂-4-F CF_Three          CH_Three        Et C (O) Et
3,5-Br₂-4-F CF_Three          CH_Three        CH₂Pr-c C (O) Et
3,5-Br₂-4-F CF_Three          CH_Three        CH₂OCH_Three    C (O) Et
3,5-Br₂-4-F CF_Three          CH_Three        CH₂CN C (O) Et
3,5-Br₂-4-F CF_Three          CH_Three        CH₂C≡CH C (O) Et
3,5-Br₂-4-F CF_Three          H H C (O) Pr-n
3,5-Br₂-4-F CF_Three          H Et C (O) Pr-n
3,5-Br₂-4-F CF_Three          H CH₂Pr-c C (O) Pr-n
3,5-Br₂-4-F CF_Three          H CH₂OCH_Three    C (O) Pr-n
3,5-Br₂-4-F CF_Three          H CH₂CN C (O) Pr-n
3,5-Br₂-4-F CF_Three          H CH₂C≡CH C (O) Pr-n
3,5-Br₂-4-F CF_Three          CH_Three        H C (O) Pr-n
3,5-Br₂-4-F CF_Three          CF_Three        H C (O) Pr-n
3,5-Br₂-4-F CF_Three          CN H C (O) Pr-n
3,5-Br₂-4-F CF_Three          C≡CH H C (O) Pr-n
3,5-Br₂-4-F CF_Three          H H C (O) Pr-i
3,5-Br₂-4-F CF_Three          CH_Three        H C (O) Pr-i
3,5-Br₂-4-F CF_Three          H H C (O) Pr-c
3,5-Br₂-4-F CF_Three          H CH_Three        C (O) Pr-c
3,5-Br₂-4-F CF_Three          H Et C (O) Pr-c
3,5-Br₂-4-F CF_Three          H n-Pr C (O) Pr-c
3,5-Br₂-4-F CF_Three          H CH₂Pr-c C (O) Pr-c
3,5-Br₂-4-F CF_Three          H CH₂OCH_Three    C (O) Pr-c
3,5-Br₂-4-F CF_Three          H CH₂CN C (O) Pr-c
3,5-Br₂-4-F CF_Three          H CH₂CH = CH₂  C (O) Pr-c
3,5-Br₂-4-F CF_Three          H CH₂C≡CH C (O) Pr-c
3,5-Br₂-4-F CF_Three          CH_Three        H C (O) Pr-c
3,5-Br₂-4-F CF_Three          CH_Three        Et C (O) Pr-c
3,5-Br₂-4-F CF_Three          CH_Three        CH₂Pr-c C (O) Pr-c
3,5-Br₂-4-F CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-c
3,5-Br₂-4-F CF_Three          CH_Three        CH₂CN C (O) Pr-c
3,5-Br₂-4-F CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3,5-Br₂-4-F CF_Three          CF_Three        H C (O) Pr-c
3,5-Br₂-4-F CF_Three          CN H C (O) Pr-c
3,5-Br₂-4-F CF_Three          C≡CH H C (O) Pr-c
3,5-Br₂-4-F CF_Three          H H C (O) Bu-i
3,5-Br₂-4-F CF_Three          H H C (O) CH₂Pr-c
3,5-Br₂-4-F CF_Three          H Et C (O) CH₂Pr-c
3,5-Br₂-4-F CF_Three          H CH₂Pr-c C (O) CH₂Pr-c
3,5-Br₂-4-F CF_Three          H CH₂OCH_Three    C (O) CH₂Pr-c
3,5-Br₂-4-F CF_Three          H CH₂CN C (O) CH₂Pr-c
3,5-Br₂-4-F CF_Three          H CH₂CH = CH₂  C (O) CH₂Pr-c
3,5-Br₂-4-F CF_Three          H CH₂C≡CH C (O) CH₂Pr-c
3,5-Br₂-4-F CF_Three          CH_Three        H C (O) CH₂Pr-c
3,5-Br₂-4-F CF_Three          CF_Three        H C (O) CH₂Pr-c
3,5-Br₂-4-F CF_Three          CN H C (O) CH₂Pr-c
3,5-Br₂-4-F CF_Three          C≡CH H C (O) CH₂Pr-c
3,5-Br₂-4-F CF_Three          H H C (O) (T-1)
3,5-Br₂-4-F CF_Three          CH_Three        H C (O) (T-1)
3,5-Br₂-4-F CF_Three          H H C (O) Bu-c
3,5-Br₂-4-F CF_Three          H H C (O) CH₂CF_Three
3,5-Br₂-4-F CF_Three          H Et C (O) CH₂CF_Three
3,5-Br₂-4-F CF_Three          H CH₂Pr-c C (O) CH₂CF_Three
3,5-Br₂-4-F CF_Three          H CH₂OCH_Three    C (O) CH₂CF_Three
3,5-Br₂-4-F CF_Three          H CH₂CN C (O) CH₂CF_Three
3,5-Br₂-4-F CF_Three          H CH₂C≡CH C (O) CH₂CF_Three
3,5-Br₂-4-F CF_Three          CH_Three        H C (O) CH₂CF_Three
3,5-Br₂-4-F CF_Three          CF_Three        H C (O) CH₂CF_Three
3,5-Br₂-4-F CF_Three          CN H C (O) CH₂CF_Three
3,5-Br₂-4-F CF_Three          C≡CH H C (O) CH₂CF_Three
3,5-Br₂-4-F CF_Three          H H C (O) CH₂CH₂CF_Three
3,5-Br₂-4-F CF_Three          H H C (O) (E-6a)
3,5-Br₂-4-F CF_Three          H Et C (O) (E-6a)
3,5-Br₂-4-F CF_Three          H CH₂Pr-c C (O) (E-6a)
3,5-Br₂-4-F CF_Three          H CH₂OCH_Three    C (O) (E-6a)
3,5-Br₂-4-F CF_Three          H CH₂CN C (O) (E-6a)
3,5-Br₂-4-F CF_Three          H CH₂C≡CH C (O) (E-6a)
3,5-Br₂-4-F CF_Three          CH_Three        H C (O) (E-6a)
3,5-Br₂-4-F CF_Three          CF_Three        H C (O) (E-6a)
3,5-Br₂-4-F CF_Three          CN H C (O) (E-6a)
3,5-Br₂-4-F CF_Three          C≡CH H C (O) (E-6a)
3,5-Br₂-4-F CF_Three          H H C (O) CH₂CH₂C≡CH
3,5-Br₂-4-F CF_Three          H H C (O) NHEt
3,5-Br₂-4-F CF_Three          H CH₂CH = CH₂  C (O) NHEt
3,5-Br₂-4-F CF_Three          H CH₂C≡CH C (O) NHEt
3,5-Br₂-4-F CF_Three          CH_Three        H C (O) NHEt
3,5-Br₂-4-F CF_Three          H H C (O) NHPr-c
3,5-Br₂-4-F CF_Three          CH_Three        H C (O) NHPr-c
3,5-Br₂-4-F CF_Three          H H C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF_Three          CH_Three        H C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,5-Br₂-4-F CF_Three          H H C (O) (T-23)
3,5-Br₂-4-F CF_Three          H H C (O) (T-33)
3,5-Br₂-4-F CF_Three          H H C (S) CH₂Pr-c
3,5-Br₂-4-F CF_Three          CH_Three        H C (S) CH₂Pr-c
3,5-Br₂-4-F CF₂Cl H H C (O) Et
3,5-Br₂-4-F CF₂Cl H H C (O) Pr-n
3,5-Br₂-4-F CF₂Cl H H C (O) Pr-i
3,5-Br₂-4-F CF₂Cl H H C (O) Pr-c
3,5-Br₂-4-F CF₂Cl CH_Three        H C (O) Pr-c
3,5-Br₂-4-F CF₂Cl H H C (O) Bu-i
3,5-Br₂-4-F CF₂Cl H H C (O) CH₂Pr-c
3,5-Br₂-4-F CF₂Cl CH_Three        H C (O) CH₂Pr-c
3,5-Br₂-4-F CF₂Cl H H C (O) CH₂CF_Three
3,5-Br₂-4-F CF₂Cl CH_Three        H C (O) CH₂CF_Three
3,5-Br₂-4-F CF₂Cl H H C (O) (E-6a)
3,5-Br₂-4-F CF₂Cl CH_Three        H C (O) (E-6a)
3,5-Br₂-4-F CF₂Cl H H C (O) NHPr-c
3,5-Br₂-4-F CF₂Cl CH_Three        H C (O) NHPr-c
3,5-Br₂-4-F CF₂Cl CH_Three        H C (O) NHCH₂C≡CH
3,5-Br₂-4-F CF₂Br H H C (O) Pr-n
3,5-Br₂-4-F CF₂Br H H C (O) Pr-c
3,5-Br₂-4-F CF₂Br H H C (O) CH₂Pr-c
3,5-Br₂-4-F CF₂Br H H C (O) CH₂CF_Three
3,5-Br₂-4-F CF₂Br H H C (O) (E-6a)
3,5-Br₂-4-F CF₂CHF₂      H H C (O) Pr-n
3,5-Br₂-4-F CF₂CHF₂      H H C (O) Pr-c
3,5-Br₂-4-F CF₂CHF₂      H H C (O) CH₂Pr-c
3,5-Br₂-4-F CF₂CHF₂      H H C (O) CH₂CF_Three
3,5-Br₂-4-F CF₂CHF₂      H H C (O) (E-6a)
3,5-Br₂-4-F CF₂CF_Three       H H C (O) Pr-n
3,5-Br₂-4-F CF₂CF_Three       H H C (O) Pr-c
3,5-Br₂-4-F CF₂CF_Three       H H C (O) CH₂Pr-c
3,5-Br₂-4-F CF₂CF_Three       H H C (O) CH₂CF_Three
3,5-Br₂-4-F CF₂CF_Three       H H C (O) (E-6a)
3,5-Br₂-4-Cl CHF₂         H H C (O) CH₂Pr-c
3,5-Br₂-4-Cl CF_Three          H H C (O) Et
3,5-Br₂-4-Cl CF_Three          H H C (O) Pr-n
3,5-Br₂-4-Cl CF_Three          H H C (O) Pr-i
3,5-Br₂-4-Cl CF_Three          H H C (O) Pr-c
3,5-Br₂-4-Cl CF_Three          CH_Three        H C (O) Pr-c
3,5-Br₂-4-Cl CF_Three          H H C (O) Bu-i
3,5-Br₂-4-Cl CF_Three          H H C (O) CH₂Pr-c
3,5-Br₂-4-Cl CF_Three          CH_Three        H C (O) CH₂Pr-c
3,5-Br₂-4-Cl CF_Three          H H C (O) CH₂CF_Three
3,5-Br₂-4-Cl CF_Three          CH_Three        H C (O) CH₂CF_Three
3,5-Br₂-4-Cl CF_Three          H H C (O) (E-6a)
3,5-Br₂-4-Cl CF_Three          CH_Three        H C (O) (E-6a)
3,5-Br₂-4-Cl CF_Three          H H C (O) NHPr-c
3,5-Br₂-4-Cl CF_Three          CH_Three        H C (O) NHPr-c
3,5-Br₂-4-Cl CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,5-Br₂-4-Cl CF₂Cl H H C (O) Pr-n
3,5-Br₂-4-Cl CF₂Cl H H C (O) Pr-c
3,5-Br₂-4-Cl CF₂Cl H H C (O) CH₂Pr-c
3,5-Br₂-4-Cl CF₂Cl H H C (O) CH₂CF_Three
3,5-Br₂-4-Cl CF₂Cl H H C (O) (E-6a)
3,4,5-Br_Three              CHF₂         H H C (O) CH₂CF_Three
3,4,5-Br_Three              CF_Three          H H C (O) Et
3,4,5-Br_Three              CF_Three          H H C (O) Pr-n
3,4,5-Br_Three              CF_Three          H H C (O) Pr-i
3,4,5-Br_Three              CF_Three          H H C (O) Pr-c
3,4,5-Br_Three              CF_Three          CH_Three        H C (O) Pr-c
3,4,5-Br_Three              CF_Three          H H C (O) Bu-i
3,4,5-Br_Three              CF_Three          H H C (O) CH₂Pr-c
3,4,5-Br_Three              CF_Three          CH_Three        H C (O) CH₂Pr-c
3,4,5-Br_Three              CF_Three          H H C (O) CH₂CF_Three
3,4,5-Br_Three              CF_Three          CH_Three        H C (O) CH₂CF_Three
3,4,5-Br_Three              CF_Three          H H C (O) (E-6a)
3,4,5-Br_Three              CF_Three          CH_Three        H C (O) (E-6a)
3,4,5-Br_Three              CF_Three          H H C (O) NHPr-c
3,4,5-Br_Three              CF_Three          CH_Three        H C (O) NHPr-c
3,4,5-Br_Three              CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,4,5-Br_Three              CF₂Cl H H C (O) Pr-n
3,4,5-Br_Three              CF₂Cl H H C (O) Pr-c
3,4,5-Br_Three              CF₂Cl H H C (O) CH₂Pr-c
3,4,5-Br_Three              CF₂Cl H H C (O) CH₂CF_Three
3,4,5-Br_Three              CF₂Cl H H C (O) (E-6a)
3,5-F₂-4-CH_Three           CF_Three          H H C (O) (E-6a)
3,5-Cl₂-4-CH_Three          CF_Three          H H C (O) Pr-n
3,4-Cl₂-5-CH_Three          CF_Three          H H C (O) Et
3,4-Cl₂-5-CH_Three          CF_Three          H H C (O) Pr-n
3,4-Cl₂-5-CH_Three          CF_Three          H H C (O) Pr-c
3,4-Cl₂-5-CH_Three          CF_Three          H H C (O) CH₂Pr-c
3,4-Cl₂-5-CH_Three          CF_Three          CH_Three        H C (O) CH₂Pr-c
3,4-Cl₂-5-CH_Three          CF_Three          H H C (O) CH₂CF_Three
3,4-Cl₂-5-CH_Three          CF_Three          CH_Three        H C (O) CH₂CF_Three
3,4-Cl₂-5-CH_Three          CF_Three          H H C (O) (E-6a)
3,4-Cl₂-5-CH_Three          CF_Three          CH_Three        H C (O) (E-6a)
3,4-Cl₂-5-CH_Three          CF_Three          CH_Three        H C (O) NHPr-c
3,4-Cl₂-5-CH_Three          CF₂Cl H H C (O) Pr-c
3,5-Br₂-4-CH_Three          CF_Three          H H C (O) CH₂Pr-c
3,4-Br₂-5-CH_Three          CF_Three          H H C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CHF₂         H H C (O) Et
3,4-F₂-5-CF_Three           CHF₂         H H C (O) Pr-n
3,4-F₂-5-CF_Three           CHF₂         H H C (O) Pr-c
3,4-F₂-5-CF_Three           CHF₂         H H C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CHF₂         CH_Three        H C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CHF₂         H H C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CHF₂         CH_Three        H C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CHF₂         H H C (O) (E-6a)
3,4-F₂-5-CF_Three           CHF₂         CH_Three        H C (O) (E-6a)
3,4-F₂-5-CF_Three           CHF₂         CH_Three        H C (O) NHPr-c
3,4-F₂-5-CF_Three           CF_Three          H H H
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H H
3,4-F₂-5-CF_Three           CF_Three          CN H H
3,4-F₂-5-CF_Three           CF_Three          H H C (O) CH_Three
3,4-F₂-5-CF_Three           CF_Three          H H C (O) Et
3,4-F₂-5-CF_Three           CF_Three          H Et C (O) Et
3,4-F₂-5-CF_Three           CF_Three          H CH₂Pr-c C (O) Et
3,4-F₂-5-CF_Three           CF_Three          H CH₂OCH_Three    C (O) Et
3,4-F₂-5-CF_Three           CF_Three          H CH₂CN C (O) Et
3,4-F₂-5-CF_Three           CF_Three          H CH₂CH = CH₂  C (O) Et
3,4-F₂-5-CF_Three           CF_Three          H CH₂C≡CH C (O) Et
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H C (O) Et
3,4-F₂-5-CF_Three           CF_Three          CH_Three        Et C (O) Et
3,4-F₂-5-CF_Three           CF_Three          CH_Three        CH₂Pr-c C (O) Et
3,4-F₂-5-CF_Three           CF_Three          CH_Three        CH₂OCH_Three    C (O) Et
3,4-F₂-5-CF_Three           CF_Three          CH_Three        CH₂CN C (O) Et
3,4-F₂-5-CF_Three           CF_Three          CH_Three        CH₂C≡CH C (O) Et
3,4-F₂-5-CF_Three           CF_Three          H H C (O) Pr-n
3,4-F₂-5-CF_Three           CF_Three          H Et C (O) Pr-n
3,4-F₂-5-CF_Three           CF_Three          H CH₂Pr-c C (O) Pr-n
3,4-F₂-5-CF_Three           CF_Three          H CH₂OCH_Three    C (O) Pr-n
3,4-F₂-5-CF_Three           CF_Three          H CH₂CN C (O) Pr-n
3,4-F₂-5-CF_Three           CF_Three          H CH₂C≡CH C (O) Pr-n
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H C (O) Pr-n
3,4-F₂-5-CF_Three           CF_Three          CF_Three        H C (O) Pr-n
3,4-F₂-5-CF_Three           CF_Three          CN H C (O) Pr-n
3,4-F₂-5-CF_Three           CF_Three          C≡CH H C (O) Pr-n
3,4-F₂-5-CF_Three           CF_Three          H H C (O) Pr-i
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H C (O) Pr-i
3,4-F₂-5-CF_Three           CF_Three          H H C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          H CH_Three        C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          H Et C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          H n-Pr C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          H CH₂Pr-c C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          H CH₂OCH_Three    C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          H CH₂CN C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          H CH₂CH = CH₂  C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          H CH₂C≡CH C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          CH_Three        Et C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          CH_Three        CH₂Pr-c C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          CH_Three        CH₂CN C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          CF_Three        H C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          CN H C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          C≡CH H C (O) Pr-c
3,4-F₂-5-CF_Three           CF_Three          H H C (O) Bu-i
3,4-F₂-5-CF_Three           CF_Three          H H C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF_Three          H Et C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF_Three          H CH₂Pr-c C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF_Three          H CH₂OCH_Three    C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF_Three          H CH₂CN C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF_Three          H CH₂CH = CH₂  C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF_Three          H CH₂C≡CH C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF_Three          CF_Three        H C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF_Three          CN H C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF_Three          C≡CH H C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF_Three          H H C (O) (T-1)
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H C (O) (T-1)
3,4-F₂-5-CF_Three           CF_Three          H H C (O) Bu-c
3,4-F₂-5-CF_Three           CF_Three          H H C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF_Three          H Et C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF_Three          H CH₂Pr-c C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF_Three          H CH₂OCH_Three    C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF_Three          H CH₂CN C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF_Three          H CH₂C≡CH C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF_Three          CF_Three        H C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF_Three          CN H C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF_Three          C≡CH H C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF_Three          H H C (O) CH₂CH₂CF_Three
3,4-F₂-5-CF_Three           CF_Three          H H C (O) (E-6a)
3,4-F₂-5-CF_Three           CF_Three          H Et C (O) (E-6a)
3,4-F₂-5-CF_Three           CF_Three          H CH₂Pr-c C (O) (E-6a)
3,4-F₂-5-CF_Three           CF_Three          H CH₂OCH_Three    C (O) (E-6a)
3,4-F₂-5-CF_Three           CF_Three          H CH₂CN C (O) (E-6a)
3,4-F₂-5-CF_Three           CF_Three          H CH₂C≡CH C (O) (E-6a)
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H C (O) (E-6a)
3,4-F₂-5-CF_Three           CF_Three          CF_Three        H C (O) (E-6a)
3,4-F₂-5-CF_Three           CF_Three          CN H C (O) (E-6a)
3,4-F₂-5-CF_Three           CF_Three          C≡CH H C (O) (E-6a)
3,4-F₂-5-CF_Three           CF_Three          H H C (O) CH₂CH₂C≡CH
3,4-F₂-5-CF_Three           CF_Three          H H C (O) NHEt
3,4-F₂-5-CF_Three           CF_Three          H CH₂CH = CH₂  C (O) NHEt
3,4-F₂-5-CF_Three           CF_Three          H CH₂C≡CH C (O) NHEt
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H C (O) NHEt
3,4-F₂-5-CF_Three           CF_Three          H H C (O) NHPr-c
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H C (O) NHPr-c
3,4-F₂-5-CF_Three           CF_Three          H H C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,4-F₂-5-CF_Three           CF_Three          H H C (O) (T-23)
3,4-F₂-5-CF_Three           CF_Three          H H C (O) (T-33)
3,4-F₂-5-CF_Three           CF_Three          H H C (S) CH₂Pr-c
3,4-F₂-5-CF_Three           CF_Three          CH_Three        H C (S) CH₂Pr-c
3,4-F₂-5-CF_Three           CF₂Cl H H C (O) Et
3,4-F₂-5-CF_Three           CF₂Cl H H C (O) Pr-n
3,4-F₂-5-CF_Three           CF₂Cl H H C (O) Pr-i
3,4-F₂-5-CF_Three           CF₂Cl H H C (O) Pr-c
3,4-F₂-5-CF_Three           CF₂Cl CH_Three        H C (O) Pr-c
3,4-F₂-5-CF_Three           CF₂Cl H H C (O) Bu-i
3,4-F₂-5-CF_Three           CF₂Cl H H C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF₂Cl CH_Three        H C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF₂Cl H H C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF₂Cl CH_Three        H C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF₂Cl H H C (O) (E-6a)
3,4-F₂-5-CF_Three           CF₂Cl CH_Three        H C (O) (E-6a)
3,4-F₂-5-CF_Three           CF₂Cl H H C (O) NHPr-c
3,4-F₂-5-CF_Three           CF₂Cl CH_Three        H C (O) NHPr-c
3,4-F₂-5-CF_Three           CF₂Cl CH_Three        H C (O) NHCH₂C≡CH
3,4-F₂-5-CF_Three           CF₂Br H H C (O) Pr-n
3,4-F₂-5-CF_Three           CF₂Br H H C (O) Pr-c
3,4-F₂-5-CF_Three           CF₂Br H H C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF₂Br H H C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF₂Br H H C (O) (E-6a)
3,4-F₂-5-CF_Three           CF₂CHF₂      H H C (O) Pr-n
3,4-F₂-5-CF_Three           CF₂CHF₂      H H C (O) Pr-c
3,4-F₂-5-CF_Three           CF₂CHF₂      H H C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF₂CHF₂      H H C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF₂CHF₂      H H C (O) (E-6a)
3,4-F₂-5-CF_Three           CF₂CF_Three       H H C (O) Pr-n
3,4-F₂-5-CF_Three           CF₂CF_Three       H H C (O) Pr-c
3,4-F₂-5-CF_Three           CF₂CF_Three       H H C (O) CH₂Pr-c
3,4-F₂-5-CF_Three           CF₂CF_Three       H H C (O) CH₂CF_Three
3,4-F₂-5-CF_Three           CF₂CF_Three       H H C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CHF₂         H H C (O) Et
3-Cl-4-F-5-CF_Three         CHF₂         H H C (O) Pr-n
3-Cl-4-F-5-CF_Three         CHF₂         H H C (O) Pr-c
3-Cl-4-F-5-CF_Three         CHF₂         H H C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CHF₂         CH_Three        H C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CHF₂         H H C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CHF₂         CH_Three        H C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CHF₂         H H C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CHF₂         CH_Three        H C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CHF₂         CH_Three        H C (O) NHPr-c
3-Cl-4-F-5-CF_Three         CF_Three          H H H
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H H
3-Cl-4-F-5-CF_Three         CF_Three          CN H H
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) CH_Three
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) Et
3-Cl-4-F-5-CF_Three         CF_Three          H Et C (O) Et
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂Pr-c C (O) Et
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂OCH_Three    C (O) Et
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂CN C (O) Et
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂CH = CH₂  C (O) Et
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂C≡CH C (O) Et
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H C (O) Et
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        Et C (O) Et
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        CH₂Pr-c C (O) Et
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        CH₂OCH_Three    C (O) Et
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        CH₂CN C (O) Et
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        CH₂C≡CH C (O) Et
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF_Three          H Et C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂Pr-c C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂OCH_Three    C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂CN C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂C≡CH C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF_Three          CF_Three        H C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF_Three          CN H C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF_Three          C≡CH H C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) Pr-i
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H C (O) Pr-i
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H CH_Three        C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H Et C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H n-Pr C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂Pr-c C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂OCH_Three    C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂CN C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂CH = CH₂  C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂C≡CH C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        Et C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        CH₂Pr-c C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        CH₂CN C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          CF_Three        H C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          CN H C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          C≡CH H C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) Bu-i
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H Et C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂Pr-c C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂OCH_Three    C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂CN C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂CH = CH₂  C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂C≡CH C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          CF_Three        H C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          CN H C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          C≡CH H C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) (T-1)
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H C (O) (T-1)
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) Bu-c
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF_Three          H Et C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂Pr-c C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂OCH_Three    C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂CN C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂C≡CH C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF_Three          CF_Three        H C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF_Three          CN H C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF_Three          C≡CH H C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) CH₂CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF_Three          H Et C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂Pr-c C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂OCH_Three    C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂CN C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂C≡CH C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF_Three          CF_Three        H C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF_Three          CN H C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF_Three          C≡CH H C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) CH₂CH₂C≡CH
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) NHEt
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂CH = CH₂  C (O) NHEt
3-Cl-4-F-5-CF_Three         CF_Three          H CH₂C≡CH C (O) NHEt
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H C (O) NHEt
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) NHPr-c
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H C (O) NHPr-c
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) (T-23)
3-Cl-4-F-5-CF_Three         CF_Three          H H C (O) (T-33)
3-Cl-4-F-5-CF_Three         CF_Three          H H C (S) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF_Three          CH_Three        H C (S) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF₂Cl H H C (O) Et
3-Cl-4-F-5-CF_Three         CF₂Cl H H C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF₂Cl H H C (O) Pr-i
3-Cl-4-F-5-CF_Three         CF₂Cl H H C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF₂Cl CH_Three        H C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF₂Cl H H C (O) Bu-i
3-Cl-4-F-5-CF_Three         CF₂Cl H H C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF₂Cl CH_Three        H C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF₂Cl H H C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF₂Cl CH_Three        H C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF₂Cl H H C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF₂Cl CH_Three        H C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF₂Cl H H C (O) NHPr-c
3-Cl-4-F-5-CF_Three         CF₂Cl CH_Three        H C (O) NHPr-c
3-Cl-4-F-5-CF_Three         CF₂Cl CH_Three        H C (O) NHCH₂C≡CH
3-Cl-4-F-5-CF_Three         CF₂Br H H C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF₂Br H H C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF₂Br H H C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF₂Br H H C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF₂Br H H C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF₂CHF₂      H H C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF₂CHF₂      H H C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF₂CHF₂      H H C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF₂CHF₂      H H C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF₂CHF₂      H H C (O) (E-6a)
3-Cl-4-F-5-CF_Three         CF₂CF_Three       H H C (O) Pr-n
3-Cl-4-F-5-CF_Three         CF₂CF_Three       H H C (O) Pr-c
3-Cl-4-F-5-CF_Three         CF₂CF_Three       H H C (O) CH₂Pr-c
3-Cl-4-F-5-CF_Three         CF₂CF_Three       H H C (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three         CF₂CF_Three       H H C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CHF₂         H H C (O) Et
3,4-Cl₂-5-CF_Three          CHF₂         H H C (O) Pr-n
3,4-Cl₂-5-CF_Three          CHF₂         H H C (O) Pr-c
3,4-Cl₂-5-CF_Three          CHF₂         H H C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CHF₂         CH_Three        H C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CHF₂         H H C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CHF₂         CH_Three        H C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CHF₂         H H C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CHF₂         CH_Three        H C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CHF₂         CH_Three        H C (O) NHPr-c
3,4-Cl₂-5-CF_Three          CF_Three          H H H
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H H
3,4-Cl₂-5-CF_Three          CF_Three          CN H H
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) CH_Three
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) Et
3,4-Cl₂-5-CF_Three          CF_Three          H Et C (O) Et
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂Pr-c C (O) Et
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂OCH_Three    C (O) Et
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂CN C (O) Et
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂CH = CH₂  C (O) Et
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂C≡CH C (O) Et
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H C (O) Et
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        Et C (O) Et
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        CH₂Pr-c C (O) Et
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        CH₂OCH_Three    C (O) Et
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        CH₂CN C (O) Et
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        CH₂C≡CH C (O) Et
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF_Three          H Et C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂Pr-c C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂OCH_Three    C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂CN C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂C≡CH C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF_Three          CF_Three        H C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF_Three          CN H C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF_Three          C≡CH H C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) Pr-i
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H C (O) Pr-i
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H CH_Three        C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H Et C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H n-Pr C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂Pr-c C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂OCH_Three    C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂CN C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂CH = CH₂  C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂C≡CH C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        Et C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        CH₂Pr-c C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        CH₂CN C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          CF_Three        H C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          CN H C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          C≡CH H C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) Bu-i
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H Et C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂Pr-c C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂OCH_Three    C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂CN C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂CH = CH₂  C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂C≡CH C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          CF_Three        H C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          CN H C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          C≡CH H C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) (T-1)
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H C (O) (T-1)
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) Bu-c
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF_Three          H Et C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂Pr-c C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂OCH_Three    C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂CN C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂C≡CH C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF_Three          CF_Three        H C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF_Three          CN H C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF_Three          C≡CH H C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) CH₂CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF_Three          H Et C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂Pr-c C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂OCH_Three    C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂CN C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂C≡CH C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF_Three          CF_Three        H C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF_Three          CN H C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF_Three          C≡CH H C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) CH₂CH₂C≡CH
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) NHEt
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂CH = CH₂  C (O) NHEt
3,4-Cl₂-5-CF_Three          CF_Three          H CH₂C≡CH C (O) NHEt
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H C (O) NHEt
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) NHPr-c
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H C (O) NHPr-c
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) NHCH₂CF_Three
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H C (O) NHCH₂CF_Three
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) (T-23)
3,4-Cl₂-5-CF_Three          CF_Three          H H C (O) (T-33)
3,4-Cl₂-5-CF_Three          CF_Three          H H C (S) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF_Three          CH_Three        H C (S) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF₂Cl H H C (O) Et
3,4-Cl₂-5-CF_Three          CF₂Cl H H C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF₂Cl H H C (O) Pr-i
3,4-Cl₂-5-CF_Three          CF₂Cl H H C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF₂Cl CH_Three        H C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF₂Cl H H C (O) Bu-i
3,4-Cl₂-5-CF_Three          CF₂Cl H H C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF₂Cl CH_Three        H C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF₂Cl H H C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF₂Cl CH_Three        H C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF₂Cl H H C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF₂Cl CH_Three        H C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF₂Cl H H C (O) NHPr-c
3,4-Cl₂-5-CF_Three          CF₂Cl CH_Three        H C (O) NHPr-c
3,4-Cl₂-5-CF_Three          CF₂Cl CH_Three        H C (O) NHCH₂C≡CH
3,4-Cl₂-5-CF_Three          CF₂Br H H C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF₂Br H H C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF₂Br H H C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF₂Br H H C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF₂Br H H C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF₂CHF₂      H H C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF₂CHF₂      H H C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF₂CHF₂      H H C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF₂CHF₂      H H C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF₂CHF₂      H H C (O) (E-6a)
3,4-Cl₂-5-CF_Three          CF₂CF_Three       H H C (O) Pr-n
3,4-Cl₂-5-CF_Three          CF₂CF_Three       H H C (O) Pr-c
3,4-Cl₂-5-CF_Three          CF₂CF_Three       H H C (O) CH₂Pr-c
3,4-Cl₂-5-CF_Three          CF₂CF_Three       H H C (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three          CF₂CF_Three       H H C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CHF₂         H H C (O) Et
3,5- (CF_Three)₂-4-Cl CHF₂         H H C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CHF₂         H H C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CHF₂         H H C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CHF₂         CH_Three        H C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CHF₂         H H C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CHF₂         CH_Three        H C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CHF₂         H H C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CHF₂         CH_Three        H C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CHF₂         CH_Three        H C (O) NHPr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H H H
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H H
3,5- (CF_Three)₂-4-Cl CF_Three          CN H H
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) CH_Three
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three          H Et C (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂Pr-c C (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂OCH_Three    C (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂CN C (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂CH = CH₂  C (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂C≡CH C (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H C (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        Et C (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        CH₂Pr-c C (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        CH₂OCH_Three    C (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        CH₂CN C (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        CH₂C≡CH C (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF_Three          H Et C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂Pr-c C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂OCH_Three    C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂CN C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂C≡CH C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF_Three          CF_Three        H C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF_Three          CN H C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF_Three          C≡CH H C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) Pr-i
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H C (O) Pr-i
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H CH_Three        C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H Et C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H n-Pr C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂Pr-c C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂OCH_Three    C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂CN C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂CH = CH₂  C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂C≡CH C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        Et C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        CH₂Pr-c C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        CH₂OCH_Three    C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        CH₂CN C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        CH₂C≡CH C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          CF_Three        H C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          CN H C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          C≡CH H C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) Bu-i
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H Et C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂Pr-c C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂OCH_Three    C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂CN C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂CH = CH₂  C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂C≡CH C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          CF_Three        H C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          CN H C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          C≡CH H C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) (T-1)
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H C (O) (T-1)
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) Bu-c
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three          H Et C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂Pr-c C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂OCH_Three    C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂CN C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂C≡CH C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three          CF_Three        H C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three          CN H C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three          C≡CH H C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) CH₂CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF_Three          H Et C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂Pr-c C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂OCH_Three    C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂CN C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂C≡CH C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF_Three          CF_Three        H C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF_Three          CN H C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF_Three          C≡CH H C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) CH₂CH₂C≡CH
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂CH = CH₂  C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three          H CH₂C≡CH C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) NHPr-c
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H C (O) NHPr-c
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) (T-23)
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (O) (T-33)
3,5- (CF_Three)₂-4-Cl CF_Three          H H C (S) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF_Three          CH_Three        H C (S) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF₂Cl H H C (O) Et
3,5- (CF_Three)₂-4-Cl CF₂Cl H H C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF₂Cl H H C (O) Pr-i
3,5- (CF_Three)₂-4-Cl CF₂Cl H H C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF₂Cl CH_Three        H C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF₂Cl H H C (O) Bu-i
3,5- (CF_Three)₂-4-Cl CF₂Cl H H C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF₂Cl CH_Three        H C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF₂Cl H H C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂Cl CH_Three        H C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂Cl H H C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF₂Cl CH_Three        H C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF₂Cl H H C (O) NHPr-c
3,5- (CF_Three)₂-4-Cl CF₂Cl CH_Three        H C (O) NHPr-c
3,5- (CF_Three)₂-4-Cl CF₂Cl CH_Three        H C (O) NHCH₂C≡CH
3,5- (CF_Three)₂-4-Cl CF₂Br H H C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF₂Br H H C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF₂Br H H C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF₂Br H H C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂Br H H C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF₂CHF₂      H H C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF₂CHF₂      H H C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF₂CHF₂      H H C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF₂CHF₂      H H C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂CHF₂      H H C (O) (E-6a)
3,5- (CF_Three)₂-4-Cl CF₂CF_Three       H H C (O) Pr-n
3,5- (CF_Three)₂-4-Cl CF₂CF_Three       H H C (O) Pr-c
3,5- (CF_Three)₂-4-Cl CF₂CF_Three       H H C (O) CH₂Pr-c
3,5- (CF_Three)₂-4-Cl CF₂CF_Three       H H C (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂CF_Three       H H C (O) (E-6a)
3,5-Cl₂-4-OCH_Three         CF_Three          H H C (O) (E-6a)
3,5-Br₂-4-OCH_Three         CF_Three          H H C (O) Pr-n
3,5-Cl₂-4-OCHF₂        CHF₂         H H C (O) Pr-c
3,5-Cl₂-4-OCHF₂        CF_Three          H H C (O) Et
3,5-Cl₂-4-OCHF₂        CF_Three          H H C (O) Pr-n
3,5-Cl₂-4-OCHF₂        CF_Three          H H C (O) Pr-i
3,5-Cl₂-4-OCHF₂        CF_Three          H H C (O) Pr-c
3,5-Cl₂-4-OCHF₂        CF_Three          CH_Three        H C (O) Pr-c
3,5-Cl₂-4-OCHF₂        CF_Three          H H C (O) Bu-i
3,5-Cl₂-4-OCHF₂        CF_Three          H H C (O) CH₂Pr-c
3,5-Cl₂-4-OCHF₂        CF_Three          CH_Three        H C (O) CH₂Pr-c
3,5-Cl₂-4-OCHF₂        CF_Three          H H C (O) CH₂CF_Three
3,5-Cl₂-4-OCHF₂        CF_Three          CH_Three        H C (O) CH₂CF_Three
3,5-Cl₂-4-OCHF₂        CF_Three          H H C (O) (E-6a)
3,5-Cl₂-4-OCHF₂        CF_Three          CH_Three        H C (O) (E-6a)
3,5-Cl₂-4-OCHF₂        CF_Three          H H C (O) NHPr-c
3,5-Cl₂-4-OCHF₂        CF_Three          CH_Three        H C (O) NHPr-c
3,5-Cl₂-4-OCHF₂        CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,5-Cl₂-4-OCHF₂        CF₂Cl H H C (O) Pr-n
3,5-Cl₂-4-OCHF₂        CF₂Cl H H C (O) Pr-c
3,5-Cl₂-4-OCHF₂        CF₂Cl H H C (O) CH₂Pr-c
3,5-Cl₂-4-OCHF₂        CF₂Cl H H C (O) CH₂CF_Three
3,5-Cl₂-4-OCHF₂        CF₂Cl H H C (O) (E-6a)
3,5-Br₂-4-OCHF₂        CHF₂         H H C (O) CH₂Pr-c
3,5-Br₂-4-OCHF₂        CF_Three          H H C (O) Et
3,5-Br₂-4-OCHF₂        CF_Three          H H C (O) Pr-n
3,5-Br₂-4-OCHF₂        CF_Three          H H C (O) Pr-i
3,5-Br₂-4-OCHF₂        CF_Three          H H C (O) Pr-c
3,5-Br₂-4-OCHF₂        CF_Three          CH_Three        H C (O) Pr-c
3,5-Br₂-4-OCHF₂        CF_Three          H H C (O) Bu-i
3,5-Br₂-4-OCHF₂        CF_Three          H H C (O) CH₂Pr-c
3,5-Br₂-4-OCHF₂        CF_Three          CH_Three        H C (O) CH₂Pr-c
3,5-Br₂-4-OCHF₂        CF_Three          H H C (O) CH₂CF_Three
3,5-Br₂-4-OCHF₂        CF_Three          CH_Three        H C (O) CH₂CF_Three
3,5-Br₂-4-OCHF₂        CF_Three          H H C (O) (E-6a)
3,5-Br₂-4-OCHF₂        CF_Three          CH_Three        H C (O) (E-6a)
3,5-Br₂-4-OCHF₂        CF_Three          H H C (O) NHPr-c
3,5-Br₂-4-OCHF₂        CF_Three          CH_Three        H C (O) NHPr-c
3,5-Br₂-4-OCHF₂        CF_Three          CH_Three        H C (O) NHCH₂C≡CH
3,5-Br₂-4-OCHF₂        CF₂Cl H H C (O) Pr-n
3,5-Br₂-4-OCHF₂        CF₂Cl H H C (O) Pr-c
3,5-Br₂-4-OCHF₂        CF₂Cl H H C (O) CH₂Pr-c
3,5-Br₂-4-OCHF₂        CF₂Cl H H C (O) CH₂CF_Three
3,5-Br₂-4-OCHF₂        CF₂Cl H H C (O) (E-6a)
3,5-Cl₂-4-SCH_Three         CF_Three          H H C (O) CH₂CF_Three
3,5-Cl₂-4-S (O) CH_Three      CF_Three          H H C (O) (E-6a)
3,5-Cl₂-4-SO₂CH_Three       CF_Three          H H C (O) Pr-n
3,5-F₂-4-NO₂           CF_Three          H H C (O) Pr-c
3,5-Cl₂-4-NO₂          CF_Three          H H C (O) CH₂Pr-c
3,5-Cl₂-4-NH₂          CF_Three          H H C (O) Pr-n
3,5-Cl₂-4-NH₂          CF_Three          H H C (O) Pr-c
3,5-Cl₂-4-NH₂          CF_Three          H H C (O) CH₂Pr-c
3,5-Cl₂-4-NH₂          CF_Three          H H C (O) CH₂CF_Three
3,5-Cl₂-4-NH₂          CF_Three          H H C (O) (E-6a)
3,5-Br₂-4-NH₂          CF_Three          H H C (O) Pr-n
3,5-Br₂-4-NH₂          CF_Three          H H C (O) Pr-c
3,5-Br₂-4-NH₂          CF_Three          H H C (O) CH₂Pr-c
3,5-Br₂-4-NH₂          CF_Three          H H C (O) CH₂CF_Three
3,5-Br₂-4-NH₂          CF_Three          H H C (O) (E-6a)
3,5-I₂-4-NH₂           CF_Three          H H C (O) CH₂CF_Three
3,5-Cl₂-4-NHC (O) OBu-t CF_Three          H H C (O) (E-6a)
3,5-Br₂-4-NHC (O) OBu-t CF_Three          H H C (O) Pr-n
3,5-Cl₂-4-N (CH_Three)₂      CF_Three          H H C (O) Pr-c
3,5-Br₂-4-N (CH_Three)₂      CF_Three          H H C (O) CH₂Pr-c
3,5-F₂-4-CN CF_Three          H H C (O) CH₂CF_Three
3,5-Cl₂-4-CN CF_Three          H H C (O) (E-6a)
3,5-Br₂-4-CN CF_Three          H H C (O) Pr-n
―――――――――――――――――――――――――――――――――――――――
Table 3
  In the table, substituent (X)_mThe numbers representing the substitution positions correspond to the positions of the numbers described in the following structural formulas,

  The substituent G in the general formulas [2] -1 and [2] -2 is an aromatic 6-membered ring represented by any one of the following G-1, G-3, and G-4, and G-13, respectively. , G-14, G-17, G-20, G-21 or G-22 represents an aromatic 5-membered ring.

  In the general formulas [2] -1 and [2] -2, the bond part represented by L represents a structure represented by any one of the following L-1 to L-24.

―――――――――――――――――――――――――――――――――――――――
G (X) _m A ¹ A ² A ³ A ³ LR ¹
―――――――――――――――――――――――――――――――――――――――
G-1 3,5-Cl ₂ CC (O) NH ₂ CH CH CH L-1 C (O) Et
G-1 3,5-Cl ₂ C (M-11a) CH CH CH L-1 C (O) Pr-n
G-1 3,5-Cl ₂ C (M-14a) CH CH CH L-1 C (O) Pr-c
G-1 3,5-Cl ₂ C (D-1a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5-Cl ₂ C (D-3a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5-Cl ₂ C (D-3a) CH CH CH L-1 C (O) CH ₂ SCH ₃
G-1 3,5-Cl ₂ C (D-3a) CH CH CH L-1 C (O) CH ₂ S (O) CH ₃
G-1 3,5-Cl ₂ C (D-3a) CH CH CH L-1 C (O) CH ₂ SO ₂ CH ₃
G-1 3,5-Cl ₂ C (D-3a) CH CH CH L-1 C (O) CH ₂ SEt
G-1 3,5-Cl ₂ C (D-3a) CH CH CH L-1 C (O) CH ₂ S (O) Et
G-1 3,5-Cl ₂ C (D-3a) CH CH CH L-1 C (O) CH ₂ SO ₂ Et
G-1 3,5-Cl ₂ C (D-5a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5-Cl ₂ C (D-14a) CH CH CH L-1 C (O) Et
G-1 3,5-Cl ₂ C (D-18a) CH CH CH L-1 C (O) Pr-n
G-1 3,5-Cl ₂ C (D-21a) CH CH CH L-1 C (O) Pr-c
G-1 3,5-Cl ₂ C (D-21a) CH CH CH L-1 C (O) CH ₂ SCH ₃
G-1 3,5-Cl ₂ C (D-21a) CH CH CH L-1 C (O) CH ₂ S (O) CH ₃
G-1 3,5-Cl ₂ C (D-21a) CH CH CH L-1 C (O) CH ₂ SO ₂ CH ₃
G-1 3,5-Cl ₂ C (D-21a) CH CH CH L-1 C (O) CH ₂ SEt
G-1 3,5-Cl ₂ C (D-21a) CH CH CH L-1 C (O) CH ₂ S (O) Et
G-1 3,5-Cl ₂ C (D-21a) CH CH CH L-1 C (O) CH ₂ SO ₂ Et
G-1 3,5-Cl ₂ C (D-41a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5-Cl ₂ CH CH CH CH L-7 C (O) (Ph-2,4,6-F ₃ )
G-1 3-Cl-5-Br CC (O) NH ₂ CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-Cl-5-Br C (M-11a) CH CH CH L-1 C (O) (E-6a)
G-1 3-Cl-5-Br C (M-14a) CH CH CH L-1 C (O) Et
G-1 3-Cl-5-Br C (D-1a) CH CH CH L-1 C (O) Pr-n
G-1 3-Cl-5-Br C (D-3a) CH CH CH L-1 C (O) Pr-c
G-1 3-Cl-5-Br C (D-5a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-Cl-5-Br C (D-14a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-Cl-5-Br C (D-18a) CH CH CH L-1 C (O) (E-6a)
G-1 3-Cl-5-Br C (D-21a) CH CH CH L-1 C (O) Et
G-1 3-Cl-5-Br C (D-41a) CH CH CH L-1 C (O) Pr-n
G-1 3-Cl-5-Br CH CH CH CH L-7 C (O) (Ph-2,4,6-F ₃ )
G-1 3,5-Br ₂ CC (O) NH ₂ CH CH CH L-1 C (O) Pr-c
G-1 3,5-Br ₂ C (M-11a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5-Br ₂ C (M-14a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5-Br ₂ C (D-1a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5-Br ₂ C (D-3a) CH CH CH L-1 C (O) Et
G-1 3,5-Br ₂ C (D-5a) CH CH CH L-1 C (O) Pr-n
G-1 3,5-Br ₂ C (D-14a) CH CH CH L-1 C (O) Pr-c
G-1 3,5-Br ₂ C (D-18a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5-Br ₂ C (D-21a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5-Br ₂ C (D-41a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5-Br ₂ CH CH CH CH L-7 C (O) (Ph-2,4,6-F ₃ )
G-1 3-Cl-5-CF ₃ CC (O) NH ₂ CH CH CH L-1 C (O) Et
G-1 3-Cl-5-CF ₃ C (M-11a) CH CH CH L-1 C (O) Pr-n
G-1 3-Cl-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) Et
G-1 3-Cl-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) Pr-n
G-1 3-Cl-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) Pr-c
G-1 3-Cl-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-Cl-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-Cl-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) (E-6a)
G-1 3-Cl-5-CF ₃ C (D-1a) CH CH CH L-1 C (O) Pr-c
G-1 3-Cl-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) Et
G-1 3-Cl-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) Pr-n
G-1 3-Cl-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) Pr-c
G-1 3-Cl-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-Cl-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-Cl-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) (E-6a)
G-1 3-Cl-5-CF ₃ C (D-5a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-Cl-5-CF ₃ C (D-14a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-Cl-5-CF ₃ C (D-18a) CH CH CH L-1 C (O) (E-6a)
G-1 3-Cl-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) Et
G-1 3-Cl-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) Pr-n
G-1 3-Cl-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) Pr-c
G-1 3-Cl-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-Cl-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-Cl-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) (E-6a)
G-1 3-Cl-5-CF ₃ C (D-24a) CH CH CH L-1 C (O) Et
G-1 3-Cl-5-CF ₃ C (D-41a) CH CH CH L-1 C (O) Et
G-1 3-Cl-5-CF ₃ CH CH CH CH L-7 C (O) (Ph-2,4,6-F ₃ )
G-1 3-Br-5-CF ₃ CC (O) NH ₂ CH CH CH L-1 C (O) Pr-n
G-1 3-Br-5-CF ₃ C (M-11a) CH CH CH L-1 C (O) Pr-c
G-1 3-Br-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) Et
G-1 3-Br-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) Pr-n
G-1 3-Br-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) Pr-c
G-1 3-Br-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-Br-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-Br-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) (E-6a)
G-1 3-Br-5-CF ₃ C (D-1a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-Br-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) Et
G-1 3-Br-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) Pr-n
G-1 3-Br-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) Pr-c
G-1 3-Br-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-Br-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-Br-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) (E-6a)
G-1 3-Br-5-CF ₃ C (D-5a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-Br-5-CF ₃ C (D-14a) CH CH CH L-1 C (O) (E-6a)
G-1 3-Br-5-CF ₃ C (D-18a) CH CH CH L-1 C (O) Et
G-1 3-Br-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) Et
G-1 3-Br-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) Pr-n
G-1 3-Br-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) Pr-c
G-1 3-Br-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-Br-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-Br-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) (E-6a)
G-1 3-Br-5-CF ₃ C (D-24a) CH CH CH L-1 C (O) Et
G-1 3-Br-5-CF ₃ C (D-41a) CH CH CH L-1 C (O) Pr-n
G-1 3-Br-5-CF ₃ CH CH CH CH L-7 C (O) (Ph-2,4,6-F ₃ )
G-1 3-I-5-CF ₃ CC (O) NH ₂ CH CH CH L-1 C (O) Pr-c
G-1 3-I-5-CF ₃ C (M-11a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-I-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) Et
G-1 3-I-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) Pr-n
G-1 3-I-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) Pr-c
G-1 3-I-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-I-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-I-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) (E-6a)
G-1 3-I-5-CF ₃ C (D-1a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-I-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) Et
G-1 3-I-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) Pr-n
G-1 3-I-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) Pr-c
G-1 3-I-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-I-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-I-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) (E-6a)
G-1 3-I-5-CF ₃ C (D-5a) CH CH CH L-1 C (O) (E-6a)
G-1 3-I-5-CF ₃ C (D-14a) CH CH CH L-1 C (O) Et
G-1 3-I-5-CF ₃ C (D-18a) CH CH CH L-1 C (O) Pr-n
G-1 3-I-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) Et
G-1 3-I-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) Pr-n
G-1 3-I-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) Pr-c
G-1 3-I-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-I-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-I-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) (E-6a)
G-1 3-I-5-CF ₃ C (D-24a) CH CH CH L-1 C (O) Pr-c
G-1 3-I-5-CF ₃ C (D-41a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-I-5-CF ₃ CH CH CH CH L-7 C (O) (Ph-2,4,6-F ₃ )
G-1 3,5- (CF ₃ ) ₂ CH CF CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CH CCl CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CH CBr CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CH CCH ₃ CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CF CF CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CF CH CF CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CF CH CH CF L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCl CF CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCl CF CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCl CF CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCl CF CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCl CF CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCl CF CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCl CCl CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCl CH CF CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCl CH CCl CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CF L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CF L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CF L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CF L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CF L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CF L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CCl L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CBr CF CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CBr CH CF CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CBr CH CH CF L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCH ₃ CF CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCH ₃ CCl CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCH ₃ CCH ₃ CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₃ CH CF CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₃ CH CCl CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCH ₃ CH CCH ₃ CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCH ₃ CH CH CF L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCH ₃ CH CH CCl L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCH ₃ CH CH CCH ₃ L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₃ NN CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCH ₃ NN CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCH ₃ NN CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₃ NN CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₃ NN CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCH ₃ NN CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CPr-n CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CPr-i CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CPr-i CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CPr-i CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CPr-i CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CPr-i CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CPr-i CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CBu-n CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CBu-s CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CBu-t CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCF ₃ CH CF CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCF ₃ CH CCl CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCF ₃ CH CH CF L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCF ₃ CH CH CCH ₃ L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCF ₃ NN CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCF ₃ NN CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCF ₃ NN CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCF ₃ NN CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCF ₃ NN CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCF ₃ NN CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCF ₂ CF ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCH ₂ OH CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCH ₂ OCH ₃ CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCH ₂ OCH ₃ CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCH ₂ OCH ₃ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₂ OCH ₃ CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₂ OCH ₃ CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCH ₂ OCH ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCH ₂ OEt CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCH ₂ OPr-n CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₂ OPr-i CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₂ OPr-c CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCH ₂ OCH ₂ CF ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCH ₂ CH ₂ OCH ₃ CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCH ₂ SCH ₃ CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCH ₂ SCH ₃ CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCH ₂ SCH ₃ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₂ SCH ₃ CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₂ SCH ₃ CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCH ₂ SCH ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCH ₂ S (O) CH ₃ CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCH ₂ SO ₂ CH ₃ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₂ SCF ₃ CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₂ S (O) CF ₃ CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCH ₂ SO ₂ CF ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCH ₂ Ph CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCH ₂ (D-14a) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCH ₂ (D-24a) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCH ₂ (D-41a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CC≡CCH ₃ CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CC≡CCl CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CC≡CBr CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CC≡CI CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CC≡CSi (CH ₃ ) ₃ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ COCH ₃ CF CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ COCH ₃ CH CF CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ COCH ₃ CH CCl CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ COEt CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ COPr-n CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ COPr-i CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ COBu-n CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ COPen-n CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ COHex-n CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ COCF ₂ Br CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ COCF ₂ CHF ₂ CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ COCF ₂ CHFCl CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ COCF ₂ CHFCF ₃ CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ COCF ₂ CHFOCF ₃ CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ COSO ₂ CH ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ COSO ₂ Et CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ COSO ₂ Pr-i CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ COSO ₂ CF ₃ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ COPh CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CS (O) CH ₃ CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CSO ₂ CH ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CSEt CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CS (O) Et CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CSO ₂ Et CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CSPr-n CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CS (O) Pr-n CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CSO ₂ Pr-n CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CSPr-i CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CS (O) Pr-i CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CSO ₂ Pr-i CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CS (O) CHF ₂ CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CSO ₂ CHF ₂ CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CS (O) CF ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CSO ₂ CF ₃ CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CSCF ₂ Br CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CS (O) CF ₂ Br CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CSO ₂ CF ₂ Br CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CSCF ₂ CHFCl CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CS (O) CF ₂ CHFCl CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CSO ₂ CF ₂ CHFCl CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CSPh CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CS (O) Ph CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CSO ₂ Ph CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CNO ₂ CH CH CF L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CNH ₂ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CNHCH ₃ CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) ₂ CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CNHEt CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CNHPr-n CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CNHPr-i CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) Et CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CN (Et) ₂ CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CNHCHO CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CNHC (O) CH ₃ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CNHC (O) Et CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CNHC (O) Pr-n CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CNHC (O) Pr-i CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CNHC (O) Pr-c CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CNHC (O) Bu-t CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CNHC (O) CF ₃ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CNHC (O) OCH ₃ CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CNHC (O) OEt CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CNHC (O) SCH ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CNHC (O) SEt CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CNHC (S) OCH ₃ CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CNHC (S) OEt CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CNHC (S) SCH ₃ CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CNHC (S) SEt CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CNHSO ₂ CH ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CNHSO ₂ CF ₃ CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) CHO CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (O) CH ₃ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (O) Et CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (O) Pr-n CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (O) Pr-i CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (O) Pr-c CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (O) Bu-t CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (O) CF ₃ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (O) OCH ₃ CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (O) OEt CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (O) SCH ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (O) SEt CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (S) OCH ₃ CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (S) OEt CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (S) SCH ₃ CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) C (S) SEt CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CN (CH ₃ ) SO ₂ CH ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CN (Et) CHO CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (O) CH ₃ CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (O) Et CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (O) Pr-n CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (O) Pr-i CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (O) Pr-c CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (O) Bu-t CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (O) CF ₃ CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (O) OCH ₃ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (O) OEt CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (O) SCH ₃ CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (O) SEt CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (S) OCH ₃ CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (S) OEt CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (S) SCH ₃ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CN (Et) C (S) SEt CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CN (Et) SO ₂ CH ₃ CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CN = CHOCH ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CN = C (CH ₃ ) OCH ₃ CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCN CF CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CC (O) OCH ₃ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CC (O) NH ₂ CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CC (O) NH ₂ CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CC (O) NH ₂ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CC (O) NH ₂ CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CC (O) NH ₂ CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CC (O) NH ₂ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (M-11a) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (M-11a) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (M-11a) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (M-11a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (M-11a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C (M-11a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (M-28a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (M-14a) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (M-14a) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (M-14a) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (M-14a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (M-14a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C (M-14a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (M-32a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CPh CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (Ph-2-F) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (Ph-4-F) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (Ph-2-Cl) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (Ph-3-Cl) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (Ph-4-Cl) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C (Ph-2-CH ₃ ) CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (Ph-3-CH ₃ ) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (Ph-4-CH ₃ ) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (Ph-3-CN) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (Ph-4-CN) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (Ph-3-NH ₂ ) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C [Ph-3-NHC (O) CH ₃ ] CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C [Ph-4-N (CH ₃ ) ₂ ] CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (1-Naph) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (D-1a) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (D-1a) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (D-1a) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-1a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-1a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C (D-1a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (D-2a) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-3a) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (D-3a) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (D-3a) CH CH CH L-1 C (O) Pr-i
G-1 3,5- (CF ₃ ) ₂ C (D-3a) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-3a) CH CH CH L-1 C (O) Bu-i
G-1 3,5- (CF ₃ ) ₂ C (D-3a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-3a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C (D-3a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (D-3a) CH CH CH L-1 C (O) NHEt
G-1 3,5- (CF ₃ ) ₂ C (D-3a) CH CH CH L-1 C (O) NHPr-c
G-1 3,5- (CF ₃ ) ₂ C (D-4a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-5a) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (D-5a) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (D-5a) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-5a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-5a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C (D-5a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (D-14a) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (D-14a) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (D-14a) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-14a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-14a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C (D-14a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (D-18a) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (D-18a) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (D-18a) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-18a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-18a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C (D-18a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (D-21a) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (D-21a) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (D-21a) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-21a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-21a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C (D-21a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (D-24a) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (D-24a) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (D-24a) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-24a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-24a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C (D-24a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (D-41a) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (D-41a) CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (D-41a) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-41a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-41a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C (D-41a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (D-48a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C (D-48b) CH ₃ CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (D-49a) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (D-50a) H CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (D-50a) CH ₃ CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-51a) H CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ C (D-51a) CH ₃ CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ C (D-52a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ C (D-53a) CH CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ C (D-53e) Cl CH CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ C (D-54a) CH CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ -CH = CHCH = CH- CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ -CH = CHCH = CH- CH CH L-1 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ -CH = CHCH = CH- CH CH L-1 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ -CH = CHCH = CH- CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ -CH = CHCH = CH- CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ -CH = CHCH = CH-CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ -N = CHCH = CH- CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ -CH = NCH = CH- CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ -CH = CHN = CH- CH CH L-1 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ -CH = CHCH = N- CH CH L-1 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-6 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-7 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-7 C (O) (Ph-3-F)
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-7 C (O) (Ph-2-SCH ₃ )
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-7 C (O) (Ph-2-NO ₂ )
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-7 C (O) (Ph-4-CN)
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-7 C (O) (Ph-2,4-F ₂ )
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-7 C (O) (Ph-2,6-F ₂ )
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-7 C (O) (Ph-2-Cl-4-F)
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-7 C (O) (Ph-2-F-4-CN)
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-7 C (O) (Ph-2,4,6-F ₃ )
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-7 C (O) (D-53b) Cl
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-7 C (O) (D-53e) Cl
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-8 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-9 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-10 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-11 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-12 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-13 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-13 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-13 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-13 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-13 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-13 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-14 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-15 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-15 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-16 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-16 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-16 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-16 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-16 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-16 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-17 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-17 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-18 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-18 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-19 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-19 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-20 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-20 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-21 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-21 C (O) Pr-c
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-22 C (O) CH ₂ Pr-c
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-22 C (O) CH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-23 C (O) (E-6a)
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-23 C (O) Et
G-1 3,5- (CF ₃ ) ₂ CH CH CH CH L-24 C (O) Pr-n
G-1 3,5- (CF ₃ ) ₂ CCl CH CH CH L-24 C (O) Pr-c
G-1 3,5-Cl ₂ -4-F CC (O) NH ₂ CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5-Cl ₂ -4-FC (M-11a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5-Cl ₂ -4-FC (M-14a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5-Cl ₂ -4-FC (D-1a) CH CH CH L-1 C (O) Et
G-1 3,5-Cl ₂ -4-FC (D-3a) CH CH CH L-1 C (O) Pr-n
G-1 3,5-Cl ₂ -4-FC (D-5a) CH CH CH L-1 C (O) Pr-c
G-1 3,5-Cl ₂ -4-FC (D-14a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5-Cl ₂ -4-FC (D-18a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5-Cl ₂ -4-FC (D-21a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5-Cl ₂ -4-FC (D-41a) CH CH CH L-1 C (O) Et
G-1 3,5-Cl ₂ -4-F CH CH CH CH L-7 C (O) (Ph-2,4,6-F ₃ )
G-1 3,4,5-Cl ₃ CC (O) NH ₂ CH CH CH L-1 C (O) Pr-n
G-1 3,4,5-Cl ₃ C (M-11a) CH CH CH L-1 C (O) Pr-c
G-1 3,4,5-Cl ₃ C (M-14a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,4,5-Cl ₃ C (D-1a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,4,5-Cl ₃ C (D-3a) CH CH CH L-1 C (O) (E-6a)
G-1 3,4,5-Cl ₃ C (D-5a) CH CH CH L-1 C (O) Et
G-1 3,4,5-Cl ₃ C (D-14a) CH CH CH L-1 C (O) Pr-n
G-1 3,4,5-Cl ₃ C (D-18a) CH CH CH L-1 C (O) Pr-c
G-1 3,4,5-Cl ₃ C (D-21a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,4,5-Cl ₃ C (D-41a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,4,5-Cl ₃ CH CH CH CH L-7 C (O) (Ph-2,4,6-F ₃ )
G-1 3,5-Br ₂ -4-F CC (O) NH ₂ CH CH CH L-1 C (O) (E-6a)
G-1 3,5-Br ₂ -4-FC (M-11a) CH CH CH L-1 C (O) Et
G-1 3,5-Br ₂ -4-FC (M-14a) CH CH CH L-1 C (O) Et
G-1 3,5-Br ₂ -4-FC (M-14a) CH CH CH L-1 C (O) Pr-n
G-1 3,5-Br ₂ -4-FC (M-14a) CH CH CH L-1 C (O) Pr-c
G-1 3,5-Br ₂ -4-FC (M-14a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5-Br ₂ -4-FC (M-14a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5-Br ₂ -4-FC (M-14a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5-Br ₂ -4-FC (D-1a) CH CH CH L-1 C (O) Pr-n
G-1 3,5-Br ₂ -4-FC (D-3a) CH CH CH L-1 C (O) Et
G-1 3,5-Br ₂ -4-FC (D-3a) CH CH CH L-1 C (O) Pr-n
G-1 3,5-Br ₂ -4-FC (D-3a) CH CH CH L-1 C (O) Pr-c
G-1 3,5-Br ₂ -4-FC (D-3a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5-Br ₂ -4-FC (D-3a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5-Br ₂ -4-FC (D-3a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5-Br ₂ -4-FC (D-5a) CH CH CH L-1 C (O) Pr-c
G-1 3,5-Br ₂ -4-FC (D-14a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5-Br ₂ -4-FC (D-18a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5-Br ₂ -4-FC (D-21a) CH CH CH L-1 C (O) Et
G-1 3,5-Br ₂ -4-FC (D-21a) CH CH CH L-1 C (O) Pr-n
G-1 3,5-Br ₂ -4-FC (D-21a) CH CH CH L-1 C (O) Pr-c
G-1 3,5-Br ₂ -4-FC (D-21a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,5-Br ₂ -4-FC (D-21a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,5-Br ₂ -4-FC (D-21a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5-Br ₂ -4-FC (D-24a) CH CH CH L-1 C (O) Et
G-1 3,5-Br ₂ -4-FC (D-41a) CH CH CH L-1 C (O) (E-6a)
G-1 3,5-Br ₂ -4-F CH CH CH CH L-7 C (O) (Ph-2,4,6-F ₃ )
G-1 3,4-F ₂ -5-CF ₃ CC (O) NH ₂ CH CH CH L-1 C (O) Et
G-1 3,4-F ₂ -5-CF ₃ C (M-11a) CH CH CH L-1 C (O) Pr-n
G-1 3,4-F ₂ -5-CF ₃ C (M-14a) CH CH CH L-1 C (O) Pr-c
G-1 3,4-F ₂ -5-CF ₃ C (D-1a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,4-F ₂ -5-CF ₃ C (D-3a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,4-F ₂ -5-CF ₃ C (D-5a) CH CH CH L-1 C (O) (E-6a)
G-1 3,4-F ₂ -5-CF ₃ C (D-14a) CH CH CH L-1 C (O) Et
G-1 3,4-F ₂ -5-CF ₃ C (D-18a) CH CH CH L-1 C (O) Pr-n
G-1 3,4-F ₂ -5-CF ₃ C (D-21a) CH CH CH L-1 C (O) Pr-c
G-1 3,4-F ₂ -5-CF ₃ C (D-41a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,4-F ₂ -5-CF ₃ CH CH CH CH L-7 C (O) (Ph-2,4,6-F ₃ )
G-1 3-Cl-4-F-5-CF ₃ CC (O) NH ₂ CH CH CH L-1 C (O) Et
G-1 3-Cl-4-F-5-CF ₃ C (M-11a) CH CH CH L-1 C (O) Pr-n
G-1 3-Cl-4-F-5-CF ₃ C (M-14a) CH CH CH L-1 C (O) Pr-c
G-1 3-Cl-4-F-5-CF ₃ C (D-1a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-Cl-4-F-5-CF ₃ C (D-3a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3-Cl-4-F-5-CF ₃ C (D-5a) CH CH CH L-1 C (O) (E-6a)
G-1 3-Cl-4-F-5-CF ₃ C (D-14a) CH CH CH L-1 C (O) Et
G-1 3-Cl-4-F-5-CF ₃ C (D-18a) CH CH CH L-1 C (O) Pr-n
G-1 3-Cl-4-F-5-CF ₃ C (D-21a) CH CH CH L-1 C (O) Pr-c
G-1 3-Cl-4-F-5-CF ₃ C (D-41a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3-Cl-4-F-5-CF ₃ CH CH CH CH L-7 C (O) (Ph-2,4,6-F ₃ )
G-1 3,4-Cl ₂ -5-CF ₃ CC (O) NH ₂ CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,4-Cl ₂ -5-CF ₃ C (M-11a) CH CH CH L-1 C (O) (E-6a)
G-1 3,4-Cl ₂ -5-CF ₃ C (M-14a) CH CH CH L-1 C (O) Et
G-1 3,4-Cl ₂ -5-CF ₃ C (D-1a) CH CH CH L-1 C (O) Pr-n
G-1 3,4-Cl ₂ -5-CF ₃ C (D-3a) CH CH CH L-1 C (O) Pr-c
G-1 3,4-Cl ₂ -5-CF ₃ C (D-5a) CH CH CH L-1 C (O) CH ₂ Pr-c
G-1 3,4-Cl ₂ -5-CF ₃ C (D-14a) CH CH CH L-1 C (O) CH ₂ CF ₃
G-1 3,4-Cl ₂ -5-CF ₃ C (D-18a) CH CH CH L-1 C (O) (E-6a)
G-1 3,4-Cl ₂ -5-CF ₃ C (D-21a) CH CH CH L-1 C (O) Et
G-1 3,4-Cl ₂ -5-CF ₃ C (D-41a) CH CH CH L-1 C (O) Pr-n
G-1 3,4-Cl ₂ -5-CF ₃ CH CH CH CH L-7 C (O) (Ph-2,4,6-F ₃ )
G-3 5-Cl CCl CH CH CH L-1 C (O) Pr-c
G-3 5-CF ₃ CCl CH CH CH L-1 C (O) CH ₂ Pr-c
G-3 5-CF ₃ -6-Cl CCl CH CH CH L-1 C (O) CH ₂ CF ₃
G-3 5-NO ₂ -6-Cl CCl CH CH CH L-1 C (O) (E-6a)
G-4 2-Cl CCl CH CH CH L-1 C (O) Et
G-4 2-Br CCl CH CH CH L-1 C (O) Pr-n
G-4 2-CF ₃ CCl CH CH CH L-1 C (O) Pr-c
G-4 2,6-F ₂ CCl CH CH CH L-1 C (O) CH ₂ Pr-c
G-4 2,6-Cl ₂ CF CH CH CH L-1 C (O) CH ₂ CF ₃
G-4 2,6-Cl ₂ CCl CH CH CH L-1 C (O) Et
G-4 2,6-Cl ₂ CCl CH CH CH L-1 C (O) Pr-n
G-4 2,6-Cl ₂ CCl CH CH CH L-1 C (O) Pr-c
G-4 2,6-Cl ₂ CCl CH CH CH L-1 C (O) CH ₂ Pr-c
G-4 2,6-Cl ₂ CCl CH CH CH L-1 C (O) CH ₂ CF ₃
G-4 2,6-Cl ₂ CCl CH CH CH L-1 C (O) (E-6a)
G-4 2,6-Cl ₂ CCl CH CH CH L-1 C (O) CH ₂ SCH ₃
G-4 2,6-Cl ₂ CCl CH CH CH L-1 C (O) CH ₂ S (O) CH ₃
G-4 2,6-Cl ₂ CCl CH CH CH L-1 C (O) CH ₂ SO ₂ CH ₃
G-4 2,6-Cl ₂ CCl CH CH CH L-1 C (O) CH ₂ SEt
G-4 2,6-Cl ₂ CCl CH CH CH L-1 C (O) CH ₂ S (O) Et
G-4 2,6-Cl ₂ CCl CH CH CH L-1 C (O) CH ₂ SO ₂ Et
G-4 2,6-Cl ₂ CBr CH CH CH L-1 C (O) (E-6a)
G-4 2,6-Cl ₂ CI CH CH CH L-1 C (O) Et
G-4 2,6-Cl ₂ CCH ₃ CH CH CH L-1 C (O) Pr-n
G-4 2,6-Cl ₂ CEt CH CH CH L-1 C (O) Pr-c
G-4 2,6-Cl ₂ CCF ₃ CH CH CH L-1 C (O) CH ₂ Pr-c
G-4 2,6-Cl ₂ CNO ₂ CH CH CH L-1 C (O) CH ₂ CF ₃
G-4 2,6-Cl ₂ CCN CH CH CH L-1 C (O) (E-6a)
G-4 2,6-Cl ₂ CC (S) NH ₂ CH CH CH L-1 C (O) Et
G-4 2,6-Cl ₂ CH CH CH CH L-2 C (O) Pr-n
G-4 2,6-Br ₂ CCl CH CH CH L-1 C (O) Pr-c
G-4 2-Br-6-CF ₃ CCl CH CH CH L-1 C (O) CH ₂ Pr-c
G-4 2,6- (CF ₃ ) ₂ CCl CH CH CH L-1 C (O) CH ₂ CF ₃
G-13 4-CF ₃ CCl CH CH CH L-1 C (O) (E-6a)
G-13 5-CF ₃ CCl CH CH CH L-1 C (O) Et
G-13 4,5-Cl ₂ CCl CH CH CH L-1 C (O) Pr-n
G-13 4-Cl-5-Br CCl CH CH CH L-1 C (O) Pr-c
G-13 4-Br-5-Cl CCl CH CH CH L-1 C (O) CH ₂ Pr-c
G-13 4,5-Br ₂ CCl CH CH CH L-1 C (O) CH ₂ CF ₃
G-14 5-CF ₃ CCl CH CH CH L-1 C (O) (E-6a)
G-17a 5-CF ₃ CCl CH CH CH L-1 C (O) Et
G-20 4-CF ₃ CCl CH CH CH L-1 C (O) Pr-n
G-20 5-CF ₃ CCl CH CH CH L-1 C (O) Pr-c
G-21 2-CF ₃ CCl CH CH CH L-1 C (O) CH ₂ Pr-c
G-22 2-Cl CCl CH CH CH L-1 C (O) CH ₂ CF ₃
―――――――――――――――――――――――――――――――――――――――
Table 4

―――――――――――――――――――――――――――――――――――――――
R ⁴ R ² R ¹ R ⁴ R ² R ¹
―――――――――――――――――――――――――――――――――――――――
HHC (O) CH ₃ H CH ₂ C≡CH C (O) CH ₂ Pr-c
H Et C (O) CH ₃ CH ₃ HC (O) CH ₂ Pr-c
H CH ₂ Pr-c C (O) CH ₃ CH ₃ (R) HC (O) CH ₂ Pr-c
H CH ₂ OCH ₃ C (O) CH ₃ CH ₃ (S) HC (O) CH ₂ Pr-c
H CH ₂ CN C (O) CH ₃ CH ₃ Et C (O) CH ₂ Pr-c
H CH ₂ CH = CH ₂ C (O) CH ₃ CH ₃ CH ₂ Pr-c C (O) CH ₂ Pr-c
H CH ₂ C≡CH C (O) CH ₃ CH ₃ CH ₂ OCH ₃ C (O) CH ₂ Pr-c
HHC (O) Et CH ₃ CH ₂ CN C (O) CH ₂ Pr-c
H CH ₃ C (O) Et CH ₃ CH ₂ CH = CH ₂ C (O) CH ₂ Pr-c
H Et C (O) Et CH ₃ CH ₂ C≡CH C (O) CH ₂ Pr-c
H n-Pr C (O) Et CF ₃ HC (O) CH ₂ Pr-c
H CH ₂ Pr-c C (O) Et CN HC (O) CH ₂ Pr-c
H CH ₂ OCH ₃ C (O) Et CN (R) HC (O) CH ₂ Pr-c
H CH ₂ OC (O) CH ₃ C (O) Et CN (S) HC (O) CH ₂ Pr-c
H CH ₂ OC (O) OCH ₃ C (O) Et C≡CH HC (O) CH ₂ Pr-c
H CH ₂ NHC (O) CH ₃ C (O) Et D-21a HC (O) CH ₂ Pr-c
H CH ₂ NHC (O) OCH ₃ C (O) Et HHC (O) (T-1)
H CH ₂ CN C (O) Et CH ₃ HC (O) (T-1)
H CH ₂ C (O) NH ₂ C (O) Et HHC (O) Bu-c
H CH ₂ C (O) NHCH ₃ C (O) Et HHC (O) CH ₂ CF ₃
H CH ₂ C (O) N (CH ₃ ) ₂ C (O) Et H CH ₃ C (O) CH ₂ CF ₃
H CH ₂ C (O) NHEt C (O) Et H Et C (O) CH ₂ CF ₃
H CH ₂ C (S) NH ₂ C (O) Et H n-Pr C (O) CH ₂ CF ₃
H CH ₂ CH = CH ₂ C (O) Et H CH ₂ Pr-c C (O) CH ₂ CF ₃
H CH ₂ C≡CH C (O) Et H CH ₂ OCH ₃ C (O) CH ₂ CF ₃
CH ₃ HC (O) Et H CH ₂ OC (O) CH ₃ C (O) CH ₂ CF ₃
CH ₃ (R) HC (O) Et H CH ₂ OC (O) OCH ₃ C (O) CH ₂ CF ₃
CH ₃ (S) HC (O) Et H CH ₂ OC (O) CH ₃ C (O) CH ₂ CF ₃
CH ₃ Et C (O) Et H CH ₂ OC (O) OCH ₃ C (O) CH ₂ CF ₃
CH ₃ CH ₂ Pr-c C (O) Et H CH ₂ NHC (O) CH ₃ C (O) CH ₂ CF ₃
CH ₃ CH ₂ OCH ₃ C (O) Et H CH ₂ NHC (O) OCH ₃ C (O) CH ₂ CF ₃
CH ₃ CH ₂ CN C (O) Et H CH ₂ CN C (O) CH ₂ CF ₃
CH ₃ CH ₂ CH = CH ₂ C (O) Et H CH ₂ C (O) NH ₂ C (O) CH ₂ CF ₃
CH ₃ CH ₂ C≡CH C (O) Et H CH ₂ C (O) NHCH ₃ C (O) CH ₂ CF ₃
CF ₃ HC (O) Et H CH ₂ C (O) N (CH ₃ ) ₂ C (O) CH ₂ CF ₃
CN HC (O) Et H CH ₂ C (O) NHEt C (O) CH ₂ CF ₃
CN (R) HC (O) Et H CH ₂ C (S) NH ₂ C (O) CH ₂ CF ₃
CN (S) HC (O) Et H CH ₂ CH = CH ₂ C (O) CH ₂ CF ₃
C≡CH HC (O) Et H CH ₂ C≡CH C (O) CH ₂ CF ₃
D-21a HC (O) Et CH ₃ HC (O) CH ₂ CF ₃
HHC (O) Pr-n CH ₃ (R) HC (O) CH ₂ CF ₃
H CH ₃ C (O) Pr-n CH ₃ (S) HC (O) CH ₂ CF ₃
H Et C (O) Pr-n CH ₃ Et C (O) CH ₂ CF ₃
H n-Pr C (O) Pr-n CH ₃ CH ₂ Pr-c C (O) CH ₂ CF ₃
H CH ₂ Pr-c C (O) Pr-n CH ₃ CH ₂ OCH ₃ C (O) CH ₂ CF ₃
H CH ₂ OCH ₃ C (O) Pr-n CH ₃ CH ₂ CN C (O) CH ₂ CF ₃
H CH ₂ OC (O) CH ₃ C (O) Pr-n CH ₃ CH ₂ CH = CH ₂ C (O) CH ₂ CF ₃
H CH ₂ OC (O) OCH ₃ C (O) Pr-n CH ₃ CH ₂ C≡CH C (O) CH ₂ CF ₃
H CH ₂ NHC (O) CH ₃ C (O) Pr-n CF ₃ HC (O) CH ₂ CF ₃
H CH ₂ NHC (O) OCH ₃ C (O) Pr-n CN HC (O) CH ₂ CF ₃
H CH ₂ CN C (O) Pr-n CN (R) HC (O) CH ₂ CF ₃
H CH ₂ C (O) NH ₂ C (O) Pr-n CN (S) HC (O) CH ₂ CF ₃
H CH ₂ C (O) NHCH ₃ C (O) Pr-n C≡CH HC (O) CH ₂ CF ₃
H CH ₂ C (O) N (CH ₃ ) ₂ C (O) Pr-n D-21a HC (O) CH ₂ CF ₃
H CH ₂ C (O) NHEt C (O) Pr-n HHC (O) CH ₂ CH ₂ CF ₃
H CH ₂ C (S) NH ₂ C (O) Pr-n H CH ₂ OCH ₃ C (O) CH ₂ CH ₂ CF ₃
H CH ₂ CH = CH ₂ C (O) Pr-n H CH ₂ C≡CH C (O) CH ₂ CH ₂ CF ₃
H CH ₂ C≡CH C (O) Pr-n CH ₃ HC (O) CH ₂ CH ₂ CF ₃
CH ₃ HC (O) Pr-n CN HC (O) CH ₂ CH ₂ CF ₃
CH ₃ (R) HC (O) Pr-n HHC (O) (E-6a)
CH ₃ (S) HC (O) Pr-n H CH ₃ C (O) (E-6a)
CH ₃ Et C (O) Pr-n H Et C (O) (E-6a)
CH ₃ CH ₂ Pr-c C (O) Pr-n H n-Pr C (O) (E-6a)
CH ₃ CH ₂ OCH ₃ C (O) Pr-n H CH ₂ Pr-c C (O) (E-6a)
CH ₃ CH ₂ CN C (O) Pr-n H CH ₂ OCH ₃ C (O) (E-6a)
CH ₃ CH ₂ CH = CH ₂ C (O) Pr-n H CH ₂ OC (O) CH ₃ C (O) (E-6a)
CH ₃ CH ₂ C≡CH C (O) Pr-n H CH ₂ OC (O) OCH ₃ C (O) (E-6a)
CF ₃ HC (O) Pr-n H CH ₂ NHC (O) CH ₃ C (O) (E-6a)
CN HC (O) Pr-n H CH ₂ NHC (O) OCH ₃ C (O) (E-6a)
CN (R) HC (O) Pr-n H CH ₂ CN C (O) (E-6a)
CN (S) HC (O) Pr-n H CH ₂ C (O) NH ₂ C (O) (E-6a)
C≡CH HC (O) Pr-n H CH ₂ C (O) NHCH ₃ C (O) (E-6a)
D-21a HC (O) Pr-n H CH ₂ C (O) N (CH ₃ ) ₂ C (O) (E-6a)
HHC (O) Pr-i H CH ₂ C (O) NHEt C (O) (E-6a)
H Et C (O) Pr-i H CH ₂ C (S) NH ₂ C (O) (E-6a)
H CH ₂ Pr-c C (O) Pr-i H CH ₂ CH = CH ₂ C (O) (E-6a)
H CH ₂ OCH ₃ C (O) Pr-i H CH ₂ C≡CH C (O) (E-6a)
H CH ₂ CN C (O) Pr-i CH ₃ HC (O) (E-6a)
H CH ₂ CH = CH ₂ C (O) Pr-i CH ₃ (R) HC (O) (E-6a)
H CH ₂ C≡CH C (O) Pr-i CH ₃ (S) HC (O) (E-6a)
CH ₃ HC (O) Pr-i CH ₃ Et C (O) (E-6a)
CH ₃ (R) HC (O) Pr-i CH ₃ CH ₂ Pr-c C (O) (E-6a)
CH ₃ (S) HC (O) Pr-i CH ₃ CH ₂ OCH ₃ C (O) (E-6a)
CN HC (O) Pr-i CH ₃ CH ₂ CN C (O) (E-6a)
HHC (O) Pr-c CH ₃ CH ₂ CH = CH ₂ C (O) (E-6a)
H CH ₃ C (O) Pr-c CH ₃ CH ₂ C≡CH C (O) (E-6a)
H Et C (O) Pr-c CF ₃ HC (O) (E-6a)
H n-Pr C (O) Pr-c CN HC (O) (E-6a)
H CH ₂ Pr-c C (O) Pr-c CN (R) HC (O) (E-6a)
H CH ₂ OCH ₃ C (O) Pr-c CN (S) HC (O) (E-6a)
H CH ₂ OC (O) CH ₃ C (O) Pr-c C≡CH HC (O) (E-6a)
H CH ₂ OC (O) OCH ₃ C (O) Pr-c D-21a HC (O) (E-6a)
H CH ₂ NHC (O) CH ₃ C (O) Pr-c HHC (O) CH ₂ S (O) CH ₃
H CH ₂ NHC (O) OCH ₃ C (O) Pr-c H CH ₃ C (O) CH ₂ S (O) CH ₃
H CH ₂ CN C (O) Pr-c H Et C (O) CH ₂ S (O) CH ₃
H CH ₂ C (O) NH ₂ C (O) Pr-c H CH ₂ C≡CH C (O) CH ₂ S (O) CH ₃
H CH ₂ C (O) NHCH ₃ C (O) Pr-c CH ₃ HC (O) CH ₂ S (O) CH ₃
H CH ₂ C (O) N (CH ₃ ) ₂ C (O) Pr-c HHC (O) CH ₂ SO ₂ CH ₃
H CH ₂ C (O) NHEt C (O) Pr-c H CH ₃ C (O) CH ₂ SO ₂ CH ₃
H CH ₂ C (S) NH ₂ C (O) Pr-c H Et C (O) CH ₂ SO ₂ CH ₃
H CH ₂ CH = CH ₂ C (O) Pr-c H CH ₂ C≡CH C (O) CH ₂ SO ₂ CH ₃
H CH ₂ C≡CH C (O) Pr-c CH ₃ HC (O) CH ₂ SO ₂ CH ₃
CH ₃ HC (O) Pr-c HHC (O) CH ₂ S (O) Et
CH ₃ (R) HC (O) Pr-c H CH ₃ C (O) CH ₂ S (O) Et
CH ₃ (S) HC (O) Pr-c H Et C (O) CH ₂ S (O) Et
CH ₃ Et C (O) Pr-c H CH ₂ C≡CH C (O) CH ₂ S (O) Et
CH ₃ CH ₂ Pr-c C (O) Pr-c CH ₃ HC (O) CH ₂ S (O) Et
CH ₃ CH ₂ OCH ₃ C (O) Pr-c HHC (O) CH ₂ SO ₂ Et
CH ₃ CH ₂ CN C (O) Pr-c H CH ₃ C (O) CH ₂ SO ₂ Et
CH ₃ CH ₂ CH = CH ₂ C (O) Pr-c H Et C (O) CH ₂ SO ₂ Et
CH ₃ CH ₂ C≡CH C (O) Pr-c H CH ₂ C≡CH C (O) CH ₂ SO ₂ Et
CF ₃ HC (O) Pr-c CH ₃ HC (O) CH ₂ SO ₂ Et
CN HC (O) Pr-c HHC (O) CH ₂ S (O) CH ₂ CF ₃
CN (R) HC (O) Pr-c HHC (O) CH ₂ SO ₂ CH ₂ CF ₃
CN (S) HC (O) Pr-c HHC (O) CH (CH ₃ ) S (O) CH ₃
C≡CH HC (O) Pr-c HHC (O) CH (CH ₃ ) SO ₂ CH ₃
D-21a HC (O) Pr-c HHC (O) (E-7b)
HHC (O) Bu-i HHC (O) (E-7c)
H Et C (O) Bu-i HHC (O) (E-8b)
H CH ₂ Pr-c C (O) Bu-i HHC (O) (E-8c)
H CH ₂ OCH ₃ C (O) Bu-i HHC (O) CH [S (O) CH ₃ ] ₂
H CH ₂ CN C (O) Bu-i HHC (O) CH [S (O) CH ₃ ] SO ₂ CH ₃
H CH ₂ CH = CH ₂ C (O) Bu-i HHC (O) CH [S (O) Et] ₂
H CH ₂ C≡CH C (O) Bu-i HHC (O) CH [S (O) Et] SO ₂ Et
CH ₃ HC (O) Bu-i HHC (O) CH ₂ CH ₂ C≡CH
CH ₃ (R) HC (O) Bu-i HHC (O) NHEt
CH ₃ (S) HC (O) Bu-i H CH ₂ CH = CH ₂ C (O) NHEt
CN HC (O) Bu-i H CH ₂ C≡CH C (O) NHEt
HHC (O) CH ₂ Pr-c CH ₃ HC (O) NHEt
H CH ₃ C (O) CH ₂ Pr-c CH ₃ (R) HC (O) NHEt
H Et C (O) CH ₂ Pr-c CH ₃ (S) HC (O) NHEt
H n-Pr C (O) CH ₂ Pr-c HHC (O) NHPr-c
H CH ₂ Pr-c C (O) CH ₂ Pr-c CH ₃ HC (O) NHPr-c
H CH ₂ OCH ₃ C (O) CH ₂ Pr-c CH ₃ (R) HC (O) NHPr-c
H CH ₂ OC (O) CH ₃ C (O) CH ₂ Pr-c CH ₃ (S) HC (O) NHPr-c
H CH ₂ OC (O) OCH ₃ C (O) CH ₂ Pr-c CH ₃ CH ₂ C≡CH C (O) NHPr-c
H CH ₂ NHC (O) CH ₃ C (O) CH ₂ Pr-c HHC (O) NHCH ₂ CF ₃
H CH ₂ NHC (O) OCH ₃ C (O) CH ₂ Pr-c CH ₃ HC (O) NHCH ₂ CF ₃
H CH ₂ CN C (O) CH ₂ Pr-c CH ₃ HC (O) NHCH ₂ C≡CH
H CH ₂ C (O) NH ₂ C (O) CH ₂ Pr-c CH ₃ (R) HC (O) NHCH ₂ C≡CH
H CH ₂ C (O) NHCH ₃ C (O) CH ₂ Pr-c CH ₃ (S) HC (O) NHCH ₂ C≡CH
H CH ₂ C (O) N (CH ₃ ) ₂ C (O) CH ₂ Pr-c CH ₃ CH ₂ C≡CH C (O) NHCH ₂ C≡CH
H CH ₂ C (O) NHEt C (O) CH ₂ Pr-c HHC (O) (T-23)
H CH ₂ C (S) NH ₂ C (O) CH ₂ Pr-c HHC (S) CH ₂ Pr-c
H CH ₂ CH = CH ₂ C (O) CH ₂ Pr-c CH ₃ HC (S) CH ₂ Pr-c
―――――――――――――――――――――――――――――――――――――――
The compounds of the present invention are stored in warehouses, so-called agricultural pests that harm agricultural and horticultural crops and trees, so-called livestock pests that parasitize livestock and poultry, so-called sanitary pests that cause various adverse effects in human living environments such as houses. Insects as so-called stored grain pests that harm cereals and the like, and mites, crustaceans, molluscs, nematodes that occur and harm in similar situations can be effectively controlled at low concentrations.

Specific examples of insects, mites, crustaceans, molluscs and nematodes that can be controlled using the compounds of the present invention include:
Adoxophyes honmai, Adoxophyes orana faciata, Archips breviplicanus, Archips fuscocupreanus, Grapholita molesta, Chama magnan Leguminivora glycinivorella), Matsumuraeses phaseoli, Pandemis heparana, Bucculatrix pyrivorella, Lyonetia clerkella, Lyonetia prunifal ringoniella), mandarin leaf moth (Phyllocnistis citrella), green moth (Acrolepiopsis sapporensis), wild moth (Acrolepiopsis suzukiella), black moth (Plutella xylostella), oyster leaf moth (Stathmopoda masinissa), cystogram tria ora gossypiella), peach sinker moth (Carposina sasakii), codling moth (Cydla pomonella), green moth (Chilo suppressalis), corn borer (Cnaphalocrocis medinalis), peach moth (Conogethes punctiferalis), cotton moth (Dia) (Etiella zinckenella), Glyphodes pyloalis, Hellula undalis, Ostrinia furnacalis, Ostrinia scapulalis, European corn borer (Ostrinia nubilaliseter, Pesta pal) ), White-tailed butterfly (Pieris brassicae), white-tailed butterfly (Pieris rapae crucivora), mugwort (Ascotis selenaria), soy bean looper (Pseudoplusia includens), chadokuga (Euproctis pseudoconspersa), maimaiga (Lymantria disparia), thymeina ), White-spotted starfish (Hyphantria cunea), white-spotted starfish (Lemyra imparilis), Akebiko-no-ha (Adris tyrannus), red-footed butterfly (Aedia leucomelas), red-footed squirrel (Agrotis ipsilon), red-tailed squirrel (Agrotis segetum) Uwaba (Ctenoplusia agnata), Helicoverpa armigera, Tobacco moth (Helicoverpa assulta), Cotton ball worm (Helicoverpa zea), Tobacco bad worm (Heliothis virescens), Mamestra brassicae, Mythimna naa ), Southern army worm (Spodoptera eridania), Spodoptera exigua, Fall army worm (Spodoptera frugiperda), Cotton leaf worm (Spodoptera littoralis), Spodoptera litura, Spodoptera litura, Spodoptera era ), Leeb Berry Moss (Endopiza viteana), tomato horn worm (Manduca quinquemaculata), tobacco horn worm (Manduca sexta) lepidopteran insects such as,
Thrips thrips (Frankliniella intonsa), Citrus thrips (Frankliniella occidentalis), Croton thrips (Prithia thrips) The total insect of the
Spotted beetle (Dolycoris baccarum), sea turtle (Eurydema rugosum), bark beetle (Eysarcoris aeneus), horseshoe beetle (Eysarcoris lewisi), white-headed beetle (Eysarcoris ventralis), subtilus , Nezara antennata, Nezara viridula, Piezodorus hybneri, Plautia crossota, Scotinophora lurida, tiger C Stink bug (Leptocorisa chinensis), Hoso-heli beetle (Riptortus clavatus), Red-headed beetle (Rhopalus msculatus), Cavelerius saccharivorus, Toba hemipterus cus, Togo hemipterus (Stephanitis pyrioides), Kuroto Bikasumi turtle (Halticus insularis), Turned plant bug (Lygus lineolaris), Nagamu sika turtle (Stenodema sibiricum), Akasika sika turtle (Stenotus rubrovittatus), Rice moss turtle (Trigonotylus caelestialium), ical Arisbori dia Green leafhopper (Balclutha saltuella), butterfly leafhopper (Epiacanthus stramineus), potato leaf hopper (Empoasca fabae), oyster leafhopper (Empoasca nipponica), Chanomidorimempei (Empoasca onukii), omenosaka ), Leafhopper leafhopper (Macrosteles striifrons), leafhopper leafhopper (Nephotettix cinctinceps), cotton-free hopper (Psuedatomoscelis seriatus), leafhopper (Laodelphax striatella), leafhopper (Nilaparvata lugens) Psylla pyrisuga, Aleurocanthus spiniferus, Silver leaf whitefly (Bemisia argentifolii), Tobacco whitefly (Bemisia tabaci), Citrus whitefly (Dialeurodes citri), Onsitsuna whitefly (trialeurous grape rum, Trialeurodes vapor Cotton Aphid (Aphis gossypii), Snowy Aphid (Aphis spiraecola), Peach Aphid (Myzus persicae), Komikan Aphid (Toxoptera aurantii), Alaska Scale Aphid (Drosicha corpulenta), Iceria scale P solani), citrus scale insect (Planococcus citri), stag beetle scale (Planococcus kuraunhiae), stag beetle scale (Pseudococcus comstocki), horn beetle (Ceroplastes ceriferus), ruby rotum (Ceroplastes rubens), red scallop Nymphalidae (Comstockaspis perniciosa), tea scale (Fiorinia theae), chanomarine scale insect (Pseudaonidia paeoniae), stag beetle (Pseudaulacaspis pentagona), scallop scale (Pseudaulacaspis prunicola), euglena (Unaspis yanonensis), Hemiptera insects such as Cimex lectularius,
Douganebubui (Anomala cuprea), Japanese common squirrel (Anomala rufocuprea), Core ohanamuri (Gametis jucunda), Nagachakogane (Heptophylla picea), Japanese beetle (Popillia japonica), Colorado potato beetle (Lepinotarsa decemlineata) White-footed beetle (Melanotus tamsuyensis), Tobacco beetle (Lasioderma serricorne), Himetaketakekisui (Epuraea domina), Green beetle (Epilachna varivestis), Nijuya-hoshi-tento (Epilachna vigintioctopunctata), T. Tribolium castaneum, Anoplophora malasiaca, Monochamus alternatus, Psacothea hilaris, Xylotrechus pyrrhoderus, callosobruchus, Callosobruchus Western Root beetle (Chaetocnema concinna), Southern corn root worm (Diabrotica undecimpunctata), Western corn root worm (Diabrotica virgifera), Northern corn root worm (Diabrotica barberi), Inedro beetle (Oulema oryzae), Phyllotreta nastriatum, Phyllotreta striol Tobet beetle (Psylliodes angusticollis), peach weevil (Rhynchites heros), aphid weevil (Cylas formicarius), cotton weevil (Anthonomus grandis), weevil (Echinocnemus squameus), weevil (Euscepes postfasciatus) Rice weevil (Lissohoptrus oryzophilus), horned weevil (Otiorhynchus sulcatus), granary weevil (Sitophilus granarius), hornet weevil (Sitophilus zeamais), bark weevil (Sphenophorus venatus vestitus moth) erus fuscipes), etc.
Soybean flies (Asphondylia yushimai), mud wings (Sitodiplosis mosellana), fruit flies (Bactrocera cucurbitae), citrus fruit flies (Bactrocera dorsalis), citrus fruit flies (Ceratitis capitata), rice moth flies Leafhopper (Agromyza oryzae), Leafworm (Chromatomyia horticola), Eggplant leaffly (Liriomyza bryoniae), Leafhopper (Liriomyza chinensis), Tomato leaffly (Liriomyza sativae), Beanworm (Liriomyza trifoli), Liriomyza trifoli (Pegomya cunicularia), apple haggot (Rhagoletis pomonella), hessian fly (Mayetiola destructor), housefly (Musca domestica), barn fly (Stomoxys calcitrans), sheep flies (Melophagus ovinus), bullflies (Hypoderma bovisma), , Sheep flies (Oestrus ovis), tsetse flies (Glossina palpalis, Glossina morsitans), black-headed ayu (Prosimulium yezoensis), bullfly (Tabanus trigonus), giant fly (Telmatoscopus albipunctatus), nipponen sip (Leptocons) Diptera, such as Aedes aegypti), Aedes albopicutus, Anopheles hyracanus sinesis,
Bumblebee (Apethymus kuri), Bumblebee (Athalia rosae), Bumblebee (Arge pagana), Bumblebee (Neodiprion sertifer), Bumblebee (Dryocosmus kuriphilus), Gantai (Eciton burchelli, Eciton schmitus), Eciton burchelli, Eciton schmitus mandarina), bulldog ant (Myrmecia spp.), fire ant (Solenopsis spp.), pharaoh ant (Monomorium pharaonis), etc.
Straight-legged insects, such as Telemacrylus emma, Kera (Gryllotalpa orientalis), Tosama grasshopper (Locusta migratoria), Oxya yezoensis, Sabaquat grasshopper (Schistocerca gregaria),
Coleoptera insects such as the white-headed beetle (Onychiurus folsomi), the Siberian white-headed beetle (Onychiurus sibiricus), the Bourletiella hortensis,
Reticulate insects such as black cockroach (Periplaneta fuliginosa), cockroach (Periplaneta japonica), German cockroach (Blattella germanica),
Termite insects such as the termites (Coptotermes formosanus), Yamato termites (Reticulitermes speratus), Taiwan termites (Odontotermes formosanus),
Insect insects such as cat fleas (Ctenocephalidae felis), dog fleas (Ctenocephalides canis), chicken fleas (Echidnophaga gallinacea), human fleas (Pulex irritans), keops mouse fleas (Xenopsylla cheopis),
Insects such as chicken lice (Menacanthus stramineus) and bovine lice (Bovicola bovis),
Lice insects such as bovine lice (Haematopinus eurysternus), porcine lice (Haematopinus suis), bovine white lice (Linognathus vituli), horned lice (Solenopotes capillatus),
Dust mites such as cyclamen dust mite (Phytonemus pallidus), chano dust mite (Polyphagotarsonemus latus), red mite dust mite (Tarsonemus bilobatus),
Spider mites (Penthaleus erythrocephalus), wheat mites (Penthaleus major), etc.
Spider mites such as rice spider mite (Oligonychus shinkajii), citrus spider mite (Panonychus citri), blue spider mite (Panonychus mori), apple spider mite (Panonychus ulmi), Kanzawa spider mite (Tetranychus kanzawai), spider mite (Tetranychus urticae), etc.
Chinese cabbage mite (Acaphylla theavagrans), tulip rust mite (Aceria tulipae), tomato rust mite (Aculops lycopersici), citrus red mite (Aculops pelekassi), apple rust mite (Aculus schlechtendali), black rust mite (Eriophyes chitrastrostrum) ), Etc.,
Acarids such as robin mite (Rhizoglyphus robini), mushroom mite (Tyrophagus putrescentiae), spinach mushroom mite (Tyrophagus similis),
Bee mites such as honeybee mite (Varroa jacobsoni),
Tick tick (Boophilus microplus), Rhipicephalus sanguineus, Tick tick (Haemaphysalis longicornis), Tick tick (Haemophysalis flava), Tick tick (Haemophysalis campanulata), Tick tick (Ixo tus tick) Amblyomma spp.), Ticks such as Dermacentor spp.
Claw mites (Cheyletiella yasguri), claw mites (Cheyletiella blakei),
Acne mites, such as Inodecarid mites (Demodex canis), Caterpillar mites (Demodex cati),
Cucumber mites such as sheep cucumber mites (Psoroptes ovis),
Spider mites, such as Sarcoptes scabiei, Caterpillar spider mite (Notoedres cati), Chicken spider mite (Knemidocoptes spp.),
Crustaceans, such as Armadillidium vulgare,
Gastropods such as Pomacea canaliculata, African mussel (Achatina fulica), Slug (Meghimatium bilineatum), Chaukoura slug (Limax Valentiana), Uskawamai (Acusta despecta sieboldiana), Mishamai mai (Euhadra peliomphala), etc.
Southern nematode nematode (Prathylenchus coffeae), Kitane-negususa nematode (Prathylenchus penetrans), Kurume rushes nematode (Prathylenchus vulnus), potato cyst nematode (Globodera rostochiensis), soybean cyst nematode (Heterodera lypter Nematodes such as root-knot nematode (Meloidogyne incognita), rice-spotted nematode (Aphelenchoides besseyi), pine wood nematode (Bursaphelenchus xylophilus),
However, the present invention is not limited to these examples.

In addition, specific examples of endoparasites such as livestock, poultry, and pet animals that can be controlled using the compound of the present invention include, for example,
Haemonchus, Trichostrongylus, Ostertagia, Nematodirus, Cooperia, Ascaris, Bunostomum, Esphagotome Genus (Oesophagostomum), Chabertia, Trichuris, Storongylus, Trichonema, Dictyocaulus, Capillaria, Heterakis ), Toxocara, Ascaridia, Oxyuris, Ancylostoma, Uncinaria, Toxacaris, Parascaris and other nematodes ,
Filariidae nematodes such as Wuchereria, Blueia, Onchoceca, Dirofilaria, Loa
Dracunculidae nematodes, such as the genus Deacunculus,
Dogworms (Dipylidium caninum), caterpillars (Taenia taeniaeformis), rodents (Taenia solium), striped tapeworms (Taenia saginata), contracted tapeworms (Hymenolepis diminuta), Benedenta (Moniezia benedeni), Tapeworms such as Diphyllobothrium latum, Manson cleftworm (Diphyllobothrium erinacei), Echinococcus granulosus, Echinococcus multilocularis,
Fasciola hepatica (F. gigantica), Westermann lung fluke (Paragonimus westermanii), hypertrophic fluke (Fasciolopsic bruski), pancreatic fluke (Eurytrema pancreaticum, E. coelomaticum), liver fluke (Clonorchis sinensis), Schistosoma Schistosoma japonicum), Schistosoma haematobium, Schistosoma mansoni, etc.,
Eimeria tenella, Eimeria acervulina, Eimeria brunetti, Eimeria maxima, Eimeria necatrix, Eimeria bovis, Eimeria bovis Eimeria spp., Such as Eimeria ovinoidalis,
Trypanosomsa cruzi, Leishmania spp., Plasmodium spp., Babesis spp., Trichomonadidae spp., Histomanas spp., Giardia (Giardia spp.), Toxoplasma spp., Entamoeba histolytica, Theileria spp.,
However, the present invention is not limited to these examples.

  Furthermore, the compound of the present invention is also effective against pests that have developed resistance to existing insecticides such as organophosphorus compounds, carbamate compounds, and pyrethroid compounds.

  That is, the compound of the present invention is composed of the order of mucous eyes (Coleoptera), reticulates (Roaches), straight moths (Grasshoppers), termites, common moths (Thrips), hemimorphs (stink bugs and leafhoppers). Eyes), Lepidoptera (Lepidoptera), Coleoptera (Coleoptera), Hymenoptera (Hymenoptera), Diptera (Flyidae), Islamic (Flea), Liceid, and other insects, ticks In addition, pests belonging to gastropods and nematodes can be effectively controlled at low concentrations. On the other hand, the compounds of the present invention are extremely useful with little adverse effect on mammals, fish, crustaceans and beneficial insects (beneficial insects such as honeybees, bumblebees, natural enemies such as honeybees, wasps, mistletoe flies, mosquitoes, and dust mites). Has features.

  When using the compound of the present invention, it is usually mixed with a suitable solid carrier or liquid carrier, and if desired, a surfactant, penetrant, spreading agent, thickener, antifreezing agent, binder, anti-caking agent. , Disintegrating agents, antifoaming agents, preservatives and anti-degradation agents, etc., and soluble concentrate, emulsion (emulsifiable concentrate), wettable powder, water-soluble powder, granular water Water dispersible granule, water soluble granule, suspension concentrate, concentrated emulsion, suspoemulsion, microemulsion, dustable powder ), Granule tablets, and emulsifiable gels, and can be put to practical use. Further, from the viewpoint of labor saving and safety improvement, the preparations of any of the above dosage forms can be provided by being enclosed in a water-soluble package such as a water-soluble capsule and a bag of a water-soluble film.

  Examples of the solid carrier include quartz, calcite, gypsum, dolomite, chalk, kaolinite, pyrophyllite, sericite, halosite, metahalosite, kibushi clay, glazed clay, porcelain stone, siegrite, and allophane. Natural minerals such as shirasu, kira, talc, bentonite, activated clay, acid clay, pumice, attapulgite, zeolite and diatomaceous earth, for example, calcined clay, perlite, shirasu balloon, vermiculite, attapulgus clay and calcined diatomaceous earth Baked products such as magnesium carbonate, calcium carbonate, sodium carbonate, sodium bicarbonate, ammonium sulfate, sodium sulfate, magnesium sulfate, diammonium hydrogen phosphate, ammonium dihydrogen phosphate and potassium chloride, such as glucose, fructose , And Sugars such as sugar and lactose, polysaccharides such as starch, powdered cellulose and dextrin, organic materials such as urea, urea derivatives, benzoic acid and benzoic acid salts, such as wood flour, cork flour, corn cobs, walnut shells and Examples include plants such as tobacco stalks, fly ash, white carbon (for example, hydrous synthetic silica, anhydrous synthetic silica, hydrous synthetic silicate, etc.) and fertilizers.

Examples of the liquid carrier include xylene, alkyl (C ₉ or C ₁₀ etc.) benzene, phenyl xylyl ethane and alkyl (C ₁ or C ₃ etc.) naphthalene and other aromatic hydrocarbons, machine oil, normal paraffin, isoparaffin and Aliphatic hydrocarbons such as naphthene, mixtures of aromatic and aliphatic hydrocarbons such as kerosene, alcohols such as ethanol, isopropanol, cyclohexanol, phenoxyethanol and benzyl alcohol, ethylene glycol, propylene glycol, diethylene glycol, hexylene glycol , Polyhydric alcohols such as polyethylene glycol and polypropylene glycol, propyl cellosolve, butyl cellosolve, phenyl cellosolve, propylene glycol monomethyl ether, propylene Ethers such as recall monoethyl ether, propylene glycol monopropyl ether, propylene glycol monobutyl ether and propylene glycol monophenyl ether, ketones such as acetophenone, cyclohexanone and γ-butyrolactone, fatty acid methyl esters, dialkyl esters of succinic acid, dialkyl esters of glutamic acid, adipine esters such as dialkyl ester and dialkyl phthalate esters, N- alkyl (C _1, C ₈ or C _12, etc.) acid amide pyrrolidone, soybean oil, linseed oil, rapeseed oil, coconut oil, such as cottonseed oil and castor oil Examples include fats and oils, dimethyl sulfoxide and water.

  These solid and liquid carriers may be used alone or in combination of two or more.

  Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkyl (mono or di) phenyl ether, polyoxyethylene (mono, di or tri) styryl phenyl ether, polyoxyethylene polyoxypropylene block copolymer, polyoxyethylene Ethylene fatty acid (mono or di) ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, castor oil ethylene oxide adduct, acetylene glycol, acetylene alcohol, ethylene oxide adduct of acetylene glycol, ethylene oxide adduct of acetylene alcohol and alkyl Nonionic surfactants such as glycosides, alkyl sulfate esters, alkylbenzene sulfonates, lignin sulfonates, Killsulfosuccinate, naphthalenesulfonate, alkylnaphthalenesulfonate, salt of formalin condensate of naphthalenesulfonic acid, salt of formalin condensate of alkylnaphthalenesulfonic acid, polyoxyethylene alkyl ether sulfate or phosphate ester salt, polyoxy Ethylene (mono or di) alkyl phenyl ether sulfate or phosphate ester salt, polyoxyethylene (mono, di or tri) styryl phenyl ether sulfate or phosphate ester salt, polycarboxylate (eg polyacrylate, polymaleate and Copolymers of maleic acid and olefins, etc.) and anionic surfactants such as polystyrene sulfonates, cationic surfactants such as alkylamine salts and alkyl quaternary ammonium salts, amino acid types and beties Amphoteric surfactants such as mold, and silicone-based surfactants and fluorinated surfactants.

  The content of these surfactants is not particularly limited, but is usually preferably in the range of 0.05 to 20 parts by weight with respect to 100 parts by weight of the preparation of the present invention. These surfactants may be used alone or in combination of two or more.

  The application amount of the compound of the present invention varies depending on the application scene, application time, application method, cultivated crops, etc., but generally 0.005 to 50 kg per hectare (ha) is appropriate as the amount of active ingredient.

  On the other hand, when using the compound of the present invention for the control of the ectoparasites of mammals and birds as domestic animals and pets, an effective amount of the compound of the present invention is administered orally together with injection additives (intramuscular, Parenteral administration such as subcutaneous, intravenous, intraperitoneal; transdermal administration such as immersion, spraying, bathing, washing, pouring-on and spotting-on and dusting; nasal administration Can be administered. The compounds of the present invention can also be administered by molded products using strips, plates, bands, collars, ear marks, limb bands, labeling devices and the like. In administration, the compound of the present invention can be in any dosage form suitable for the administration route.

  Arbitrary forms to be prepared include solid preparations such as powders, granules, wettable powders, pellets, tablets, large pills, capsules, molded products containing active compounds; injection solutions, oral solutions, skin Liquid preparations used above or in body cavities; solution preparations such as pour-on, spot-on, flowable, and emulsion; semi-solid preparations such as ointments and gels.

  The solid preparation can be mainly used for oral administration or transdermal administration after dilution with water or environmental treatment. Solid preparations can be prepared by adding the active compound, if necessary, with adjuncts, mixing with appropriate excipients, and converting to the desired shape. Suitable excipients include, for example, inorganic substances such as carbonates, bicarbonates, phosphates, aluminum oxides, silicas, clays, and organic substances such as sugars, cellulose, crushed grains, and starches.

  Injection solutions can be administered intravenously, intramuscularly and subcutaneously. Injection solutions dissolve the active compound in a suitable solvent and, if necessary, solubilizers, acids, bases, buffer salts, antioxidants. And can be prepared by adding additives such as protective agents. Suitable solvents include water, ethanol, butanol, benzyl alcohol, glycerin, propylene glycol, polyethylene glycol, N-methylpyrrolidone and mixtures thereof, physiologically acceptable vegetable oils, synthetic oils suitable for injection, and the like. Examples of solubilizers include polyvinylpyrrolidone, polyoxyethylated castor oil, and polyoxyethylated sorbitan ester. Protecting agents include benzyl alcohol, trichlorobutanol, p-hydroxybenzoic acid ester and n-butanol.

  Oral solutions can be administered directly or diluted. It can be prepared in the same manner as an injectable solution.

  Flowables, emulsions, etc. can be administered directly or diluted transdermally or by environmental treatment.

  Solutions for use on the skin can be administered by dripping, spreading, rubbing, spraying, spraying or applying by dipping (dipping, bathing or washing). These solutions can be prepared in the same manner as injection solutions.

  Pour-on and spot-on agents can be dripped or sprayed onto a limited area of the skin, so that the active compound can be immersed in the skin and act systemically . Drops and drop preparations can be prepared by dissolving, suspending or emulsifying the active ingredient in suitable skin-compatible solvents or solvent mixtures. If necessary, auxiliary agents such as surfactants, colorants, absorption promoting substances, antioxidants, light stabilizers and adhesives may be added.

  Suitable solvents include water, alkanol, glycol, polyethylene glycol, polypropylene glycol, glycerin, benzyl alcohol, phenylethanol, phenoxyethanol, ethyl acetate, butyl acetate, benzyl benzoate, dipropylene glycol monomethyl ether, diethylene glycol monobutyl ether, acetone, Methyl ethyl ketone, aromatic and / or aliphatic hydrocarbons, vegetable or synthetic oil, DMF, liquid paraffin, light liquid paraffin, silicone, dimethylacetamide, N-methylpyrrolidone or 2,2-dimethyl-4-oxy-methylene-1, 3-dioxolane is mentioned. Absorption enhancers include DMSO, isopropyl myristate, dipropylene glycol pelargonate, silicone oil, aliphatic esters, triglycerides and fatty alcohols. Antioxidants include sulfites, metabisulfites, ascorbic acid, butylhydroxytoluene, butylhydroxyanisole and tocopherol.

  The emulsion can be administered orally, transdermally or as an injection. In emulsions, the active ingredient is dissolved in a hydrophobic phase or a hydrophilic phase, and this is added with a suitable emulsifier, and if necessary, a colorant, an absorption promoting substance, a protective agent, an antioxidant, a light-shielding agent, a thickening substance, etc. Can be prepared by homogenizing with other phase solvents together with other auxiliary agents.

  As hydrophobic phase (oil), paraffin oil, silicone oil, sesame oil, almond oil, castor oil, synthetic triglyceride, ethyl stearate, di-n-butylyl adipate, hexyl laurate, dipropylene glycol pelargonate, branched chain Of a short fatty acid having a chain length and a saturated fatty acid having a chain length of C16 to C18, isopropyl myristate, isopropyl palmitate, capryl / caprate of a saturated fatty alcohol having a chain length of C12 to C18, isopropyl stearate, oleyl oleate Decyl oleate, ethyl oleate, ethyl lactate, waxy fatty acid ester, dibutyl phthalate, diisopropyl adipate, isotridecyl alcohol, 2-octyldodecanol, cetyl stearyl alcohol, oleyl alcohol It is.

  Examples of the hydrophilic phase include water, propylene glycol, glycerin, and sorbitol.

  Emulsifiers include nonionic interfaces such as polyoxyethylated castor oil, polyoxyethylated sorbitan monoolefin acid, sorbitan monostearate, glyceryl monostearate, polyoxyethyl stearate, alkylphenol polyglycol ether, etc. Activators; amphoteric surfactants such as disodium N-lauryl-β-iminodipropionate and lecithin; anions such as sodium lauryl sulfate, fatty alcohol sulfate ether, monoethanolamine salt of mono / dialkyl polyglycol orthophosphate Surfactants; cationic surfactants such as cetyltrimethylammonium chloride.

  Other adjuvants include carboxymethyl cellulose, methyl cellulose, polyacrylate, alginate, gelatin, gum arabic, polyvinyl pyrrolidone, polyvinyl alcohol, methyl vinyl ether, a copolymer of maleic anhydride, polyethylene glycol, wax, colloidal silica.

  Semi-solid preparations can be administered by application on the skin or spreading or introduction into body cavities. Gels can be prepared by adding sufficient thickener to a solution prepared as described above for an injectable solution to produce a clear material having an ointment-like consistency.

  Next, formulation examples of the preparation when the compound of the present invention is used are shown. However, the formulation examples of the present invention are not limited to these. In the following formulation examples, “parts” means parts by weight.

[Wettable powder]
Compound of the present invention 0.1-80 parts Solid carrier 5-98.9 parts Surfactant 1-10 parts Others 0-5 parts Others include, for example, anti-caking agents and decomposition inhibitors.

[Milk]
Compound of the present invention 0.1 to 30 parts Organic solvent 45 to 95 parts Surfactant 4.9 to 30 parts Water 0 to 50 parts Others 0 to 10 parts Others include, for example, spreading agents and decomposition inhibitors.

[Suspension]
Compound of the present invention 0.1 to 70 parts Liquid carrier 15 to 98.89 parts Surfactant 1 to 12 parts Others 0.01 to 30 parts Other examples include antifreezing agents and thickeners.

(Granule wettable powder)
Compound of the present invention 0.1 to 90 parts Solid carrier 0 to 98.9 parts Surfactant 1 to 20 parts Others 0 to 10 parts Others include, for example, binders and decomposition inhibitors.

(Liquid)
Compound of the present invention 0.01 to 70 parts Liquid carrier 20 to 99.99 parts Others 0 to 10 parts Other examples include antifreezing agents and spreading agents.

[Granule]
Compound of the present invention 0.01 to 80 parts Solid carrier 10 to 99.99 parts Others 0 to 10 parts Others include, for example, binders, decomposition inhibitors and the like.

[Dust]
Compound of the present invention 0.01 to 30 parts Solid support 65 to 99.99 parts Others 0 to 5 parts Other examples include a drift inhibitor and a decomposition inhibitor.

  Next, although the formulation example which uses this invention compound as an active ingredient is shown more concretely, this invention is not limited to these.

  In the following formulation examples, “parts” means parts by weight.

[Formulation Example 1] wettable powder Compound No. 2-364 20 parts Pyrophyllite 74 parts Solpol 5039 4 parts (mixture of nonionic surfactant and anionic surfactant: Toho Chemical Co., Ltd.) Product name)
Carplex # 80D 2 parts (Synthetic hydrous silicic acid: Shionogi & Co., Ltd. trade name)
The above is uniformly mixed and ground to obtain a wettable powder.

[Formulation Example 2] Milk Compound of the present invention No. 2-368 5 parts Xylene 75 parts N-methylpyrrolidone 15 parts Solpol 2680 5 parts (mixture of nonionic surfactant and anionic surfactant: Toho Chemical Industry (Product name)
The above is uniformly mixed to obtain an emulsion.

[Composition Example 3] Milk Compound of the present invention No. 2-388 4 parts DBE 36 parts (mixture of dimethyl adipate, dimethyl glutarate, dimethyl succinate: trade name, manufactured by INVISTA)
Diisobutyl adipate 30 parts N-methylpyrrolidone 10 parts Soprophor BSU 14 parts (Nonionic surfactant: Rhodia trade name)
6 parts of rhodacal 70BC (anionic surfactant: Rhodia brand name)
The above is uniformly mixed to obtain an emulsion.

[Formulation Example 4] Emulsion Invention Compound No. 2-375 4 parts DBE 11 parts (mixture of dimethyl adipate, dimethyl glutarate, dimethyl succinate: trade name, manufactured by INVISTA)
Diisobutyl adipate 30 parts N-methylpyrrolidone 5 parts Soprophor BSU 14 parts (Nonionic surfactant: Rhodia trade name)
6 parts of rhodacal 70BC (anionic surfactant: Rhodia brand name)
Propylene glycol 10 parts Water 20 parts or more are mixed uniformly to make an emulsion.

[Formulation Example 5] Suspension Agent Compound No. 2-379 25 parts Agrisol S-710 10 parts (Nonionic surfactant: trade name of Kao Corporation)
LUNOX 1000C 0.5 part (anionic surfactant: Toho Chemical Industries, Ltd. trade name)
Xanthan gum 0.2 parts water 64.3 parts After uniformly mixing the above, wet pulverize to make a suspension.

[Composition Example 6] Granule wettable powder Present compound No.2-386 75 parts Hytenol NE-15 5 parts (Anionic surfactant: Daiichi Kogyo Seiyaku Co., Ltd. trade name)
Vanillex N 10 parts (anionic surfactant: Nippon Paper Industries Co., Ltd. trade name)
Carplex # 80D 10 parts (Synthetic hydrous silicic acid: Shionogi Pharmaceutical Co., Ltd. trade name)
After uniformly mixing and pulverizing the above, a small amount of water is added, stirred and mixed, granulated with an extrusion granulator, and dried to obtain a granulated wettable powder.

[Formulation Example 7] Granules Invention compound No. 2-392 5 parts Bentonite 50 parts Talc 45 parts After uniformly mixing and pulverizing the above, a small amount of water is added and mixed with stirring, and granulated with an extrusion granulator. And dried into granules.

[Composition Example 8] Powder Compound of the present invention No. 2-402 3 parts Carplex # 80D 0.5 part (Synthetic hydrous silicic acid: Shionogi & Co., Ltd. trade name)
Kaolinite 95 parts Diisopropyl phosphate 1.5 parts The above is uniformly mixed and ground to obtain a powder.

  In use, the above preparation is diluted 1 to 10000 times with water or sprayed directly without dilution.

[Formulation Example 9] wettable powder preparation Compound No. 7-059 of the present invention 25 parts sodium diisobutylnaphthalenesulfonate 1 part calcium n-dodecylbenzenesulfonate 10 parts alkylaryl polyglycol ether 12 parts naphthalenesulfonic acid formalin condensate Sodium salt 3 parts Emulsion type silicone 1 part Silicon dioxide 3 parts Kaolin 45 parts [Formulation Example 10] Water-soluble thickener preparation Compound No. 2-385 20 parts Polyoxyethylene lauryl ether 3 parts Sodium dioctylsulfosuccinate 3. 5 parts dimethyl sulfoxide 37 parts 2-propanol 36.5 parts [Formulation Example 11] Solution for spraying the present compound No. 7-074 2 parts dimethyl sulfoxide 10 parts 2-propanol 35 parts acetone 53 parts [Formulation Example 12] transdermal Solution for administration The present compound No. 7-08 5 parts Hexylene glycol 50 parts Isopropanol 45 parts [Formulation 13] Solution for transdermal administration Compound No. 2-385 of the present invention 5 parts Propylene glycol monomethyl ether 50 parts Dipropylene glycol 45 parts [Formulation 14] Transdermal administration ( Solution for dripping) The present compound No. 7-074 2 parts light liquid paraffin 98 parts [Formulation Example 15] Solution for transdermal administration (drip) Compound No. 7-087 2 parts light liquid paraffin 58 parts olive oil 30 parts ODO-H 9 parts Shin-Etsu Silicone 1 part In addition, when the compound of the present invention is used as an agrochemical, other types of herbicides, various insecticides, acaricides, nematicides, and the like when formulated or sprayed as necessary Further, it may be mixed with a fungicide, a plant growth regulator, a synergist, a fertilizer, a soil conditioner and the like.

  In particular, when mixed with other pesticides or plant hormones, the cost can be reduced by reducing the amount of applied medicine, the insecticidal spectrum can be expanded by the synergistic action of the mixed drugs, and higher pest control effects can be expected. At this time, a combination with a plurality of known agricultural chemicals is also possible. Examples of the type of agricultural chemical used in combination with the compound of the present invention include compounds described in The Pesticide Manual 14th edition, 2006, and the like. Specific examples of common names are as follows, but the general names are not necessarily limited to these.

  Bactericides: acibenzolar-S-methyl, acylaminobenzamide, acypetacs, aldimorph, amisulbrom, amobam, ampropyfos, Anilazine, azaconazole, azithiram, azoxystrobin, barium polysulfide, benalaxyl, benodanil, benomyl, benquinox , Benthaluron, benthiavalicarb, benthiazole, benzamacril, benzamorf, bethoxazine, binapacryl, biphenyl, bitertanol ,blast Idin-S (blasticidin-S), Bordeaux mixture, boscalid, bromoconazole, bupirimate, buthiobate, calcium polysulfide, captafol , Captan, carpropamid, carbamorph, carbendazim, carboxin, carvone, carvone, cheshunt mixture, chinomethionat, clobenazone (Chlobenthiazone), chloraniformethane, chloranil, chlorfenazol, chloroneb, chloropicrin, chlorothalonil, chlorquinox, clozolinate linate), climbazole, clotrimazole, copper acetate, basic carbonate, copper carbonate, copper hydroxide, copper naphthenate , Copper oleate, copper oxychloride, copper sulfate, copper sulfate, basic, copper zinc chromate, cufraneb, Cuprobam, cyazofamid, cyclafuramid, cycloheximide, cyflufenamid, cymoxanil, cypendazole, cyproconazol, din , Cyprofuram, dazomet, debacarb, decafenci Decafentin, dehydroacetic acid, dichlofluanid, dichlone, dichlorophen, dichlorophenoline, diclobutrazol, diclocymet, diclocymet, Diclomedine, dicloran, diethofencarb, difenoconazole, diflumetorim, dimethirimol, dimethomorph, dimethomorph, dimoxystrobin, dimoxystrobin M (diniconazole-M), dinobuton, dinocap, dinocap-4, dinocap-6, dinoton, dinosulfon, dinoterbon , Diphenylamine mine, dipyrithione, ditalimfos, dithianon, dodemorph, dodine, drazoxolone, edifenphos, epoxiconazole, etaconazole, eta Etem, ethirimol, ethoxyquin, etridiazole, famoxadone, fenarimol, febuconazole, fenamidone, fenaminosulf, fenilil ), Fendazosulam, fenfuram, fenhexamid, fenitropan, fenoxanil, fenpiclonil, fenpropidin, fenproidin Morph (fenpropimorph), fentin, ferbam, ferimzone, fluazinam, fludioxonil, flumetover, flumetover, flumorph, fluopicolide, fluoroimide , Fluotrimazole, fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, flutolanil, flutriafol, folpet , Fosetyl-aluminium, fuberidazole, furalaxyl, furametpyr, furcarbanil, furconanol, fluconazole-cis, furconazole-cis Memecyclox, furphanate, glyodin, griseofulvin, guazatine, halacrineate, hexachlorobenzene, hexaconazole, hexylthiofos , Hydroxyquinoline sulfate, hymexazol, imazalil, imibenconazole, iminoctadine, ipconazole, iprobenfos, iprobenfos, proprobion (Iprovalicarb), isoprothiolane, isovaledione, kasugamycin, kresoxim-methyl, mancopper, mancozeb ozeb, mandipropamid, maneb, mebenil, mecarbinzid, mepanipyrim, mepronil, metalaxyl, metalaxyl-M, metalaxyl-M ), Metazoxolon, metconazole, methasulfocarb, metfuroxam, methyl isothiocyanate, metiram, metinofenstro, metolafenone, metrafenone Metsulfovax, milneb, microbutanil, myclozolin, nabam, natamycin, nickel bis (dimethyldithiocarbamate), Nitrostyrene, nitrothal-isopropyl, nuarimol, ochirinone, octhilinone, offurace, orysastrobin, oxadixyl, organic copper ( oxine copper, oxycarboxin, oxpoconazole fumarate, pefurzoate, penconazole, pencycuron, penthiopyrad, ortho-phenylphenol ), Phosdiphen, phthalide, picoxystrobin, piperalin, polycarbamate, polyoxins, polyoxorim, potassium azide potassium azide, potassium hydrogen carbonate, proquinazid, probenazir, prochloraz, prochlorazone, promomidone, propamocarb hydrochloride, propiconazole, propiconazole (propiconazole) propineb, prothiocarb, prothioconazole, pyracarbolid, pyraclostrobin, pyrazophos, pyridiinitril, pyrifenox, pyrimethanil, piroculanil (Pyroquilon), pyroxychlor, pyroxyfur, quinomethionate, quinoxyfen, quintozene, quinacetosulfate (quinaceto) l-sulfate), quinazamid, quinconazole, rabenzazole, sodium azide, sodium hydrogen carbonate, sodium hypochlorite, sulfur ( sulfur, spiroxamine, salicylanilide, silthiofam, simeconazole, tebuconazole, tecnazene, tecoram, tetraconazole, thiabendazole thiabendazole thiabendazole thiabendazole thiabendazole thiabendazole thiabendazole thiabendazole thiabendazole thiabendazole thiabendazole thiabendazole thiabendazole thiabendazole thiabendazole thiabendazole th , Thiadifluor, thicyofen, thifluzamide, thiochlorfenphim, thiophanate, thiophanate-methyl, thioquinox, thira (Thiram), thiadinil, tioxymid, tolclofos-methyl, tolylfluanid, triadimefon, triadimenol, triamiphos, triarimol, Triazoxide, triazbutil, tributyltin oxide, trichlamide, tricyclazole, triridemorph, trifloxystrobin, triflumizole, triphorin (triflumizole) triforine, triticonazole, validamycin, vinclozolin, zalilamide, zinc sulfate, zineb, ziram, zoxamid e) and shiitake mycelium extract.

  Bactericides: benzalkonium chloride, bithionol, bronopol, cresol, formaldehyde, nitrapyrin, oxolinic acid, oxyterracycline , Streptomycin and tecloftalam.

  Nematicides: aldoxycarb, cadusafos, DDBCP, dichlofenthion, DSP (DSP), etoprophos, fenamiphos, fensulfothion, fostiazeto (Fosthiazate), fosthietan, imiciafos, isamifos, isazofos, oxamyl and thionazin.

  Acaricides: acequinocyl, acrinathrin, amitraz, BCI-033 (test name), bifenazate, bromopropylate, chinomethionat, chlorobezilate , Clofentezine, cyenopyrafen, cyflumetofen, cyhexatine, dicofol, dienochlor, denochlor (DNOC), etoxazole, quinazaquin (fenaza) Fenbutatin oxide, fenothiocarb, fenpropathrin, fenpyroximate, fluacrypyrim, halfenprox (halfenpro) x), hexythiazox, milbemectin, propargite, pyridaben, pyrimidifen, S-1870 (test name), spirodiclofen, spiromesifen ( spyromesifen) and tebufenpyrad.

  Insecticides: abamectin, acephate, acetamipirid, alanycarb, aldicarb, allethrin, azinphos-methyl, bacillus thuringiensis ), Bendiocarb, benfuracarb, bensultap, bifenthrin, buprofezin, butocarboxim, carbaryl, carbofuran, carbosulfan , Cartap, chlorantraniliprole, chlorfenapyr, chlorfenvinphos, chlorfluazuron, chlorpyrifos, chlorpyrifos, chlorpyrifos Pyrifos-methyl, chromafenozide, clothianidin, cycloprothrin, cyflumetofen, cyfluthrin, beta-cyfluthrin, cyhalothrin, cyhalothrin Lambda-cyhalothrin, cypermethrin, cyromazine, deltamethrin, diacloden, diafenthiuron, diazinon, dichlorvos, diflubenzuron diflubenzuron, dimethylvinphos, dinotefuran, diofenolan, disulfoton, dimethoate, emamectin-benzoat e), EPN, esfenvalerate, ethiofencarb, ethiprole, etofenprox, etrimfos, fenitrothion, fenobucarb, phenoxy curve fenoxycarb), fenpropathrin, fenthion, fenvalerate, fipronil, flonicamid, flubendiamide, flucythrinate, flufenerim, flufenerim Flufenoxuron, flufenprox, fluvalinate, tau-fluvalinate, fonophos, formetanate, formoti ON, formothion, furathiocarb, halofenozide, hexaflumuron, hydramethylnon, imidacloprid, isofenphos, indoxacarb, isoprocarb , Isoxathion, lepimectin, lufenuron, malathion, metalaldehyde, metamidophos, methidathion, methacrifos, metaflumizone, metaflumizone , Metomyl, metoprene, methoxychlor, methoxyfenozide, methyl bromide, monocrotophos Muscalure, nitenpyram, novaluron, omethoate, oxamyl, oxydemeton-methyl, oxydeprofos, parathion, parathion-methyl ( parathion-methyl, pentachlorophenol (PCP), permethrin, phenthoate, phenthoate, phoxim, phorate, phosalone, phosmet, phosphamidon, Pirimicarb, pirimiphos-methyl, profenfos, prothiofos, propaphos, protrifenbute, pymetrozine, pyraclofos, pyridali (Pyridalyl), pyrifluquinazon, pyriproxyfen, rotenone, SI-0405 (study name), sulprofos, silafluofen, spintoram, spinosad, spirosad Tetramart (spirotetramat), sulfotep (sulfotep), SYJ-159 (test name), tebfenozide (tebfenozide), teflubenzuron (teflubenzuron), tefluthorin (tefluthorin), terbufos (terbufos), tetrachlorovinphos (tetrachlorvinphos), thiacloprid (thiacloprid) ), Thiocyclam, thiodicarb, thiamethoxam, thiofanox, thiometon, tolfenpyrad, tralomethrin, triclometh Hong (trichlorfon), Toriazuron (triazuron), such as triflumuron (triflumuron) and vamidothion (vamidothion).

  Hereinafter, the present invention will be described in more detail by specifically describing synthesis examples and test examples of the compounds of the present invention as examples, but the present invention is not limited thereto.

[Synthesis example]
Synthesis example 1
Production of the compound of the present invention using L-COS (parallel liquid layer synthesizer from MRITEX).

Step 1: Preparation of 3,5-dichloro-1- [1- (trifluoromethyl) ethenyl] benzene To a solution of 25.0 g 3,5-dichlorophenylboric acid in 200 ml tetrahydrofuran and 100 ml water, 2-bromo-3,3 , 3-trifluoropropene (27.5 g), potassium carbonate (38.0 g) and dichlorobis (triphenylphosphine) palladium (II) (1.84 g) were added, and the mixture was stirred for 3 hours under heating to reflux. After completion of the reaction, the mixture was allowed to cool to room temperature, 500 ml of ice water was added, and the mixture was extracted with ethyl acetate (500 ml × 1). The organic layer was washed with water, dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography eluting with hexane to obtain 25.7 g of the desired product as a colorless oil. It was.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.41 (t, J = 2.0Hz, 1H), 7.3-7.35 (m, 2H), 6.05 (q, J = 3.2Hz, 1H), 5.82 ( q, J = 3.2Hz, 1H).

Step 2; Preparation of methyl 4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzoate 4- (hydroxyiminomethyl) methyl benzoate 2 2.04 g of N-chlorosuccinimide was added to a solution of .70 g of N, N-dimethylformamide in 15 ml and stirred at 40 ° C. for 40 minutes. The reaction mixture was then cooled to 0 ° C., 3.40 g of 3,5-dichloro-1- [1- (trifluoromethyl) ethenyl] benzene and 1.72 g of triethylamine were added, and stirring was continued for another 18 hours at room temperature. After completion of the reaction, the reaction mixture was poured into 100 ml of ice water, extracted with ethyl acetate (50 ml × 2), the organic layer was washed with water, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. . The residual solid was purified by medium pressure preparative liquid chromatography (Yamazen Co., Ltd. medium pressure preparator; YFLC-Wprep) eluting with ethyl acetate-hexane (1: 1 to 1: 3 gradient). 4.05 g was obtained as white crystals.
Melting point 94.0-96.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ8.10 (d, J = 8.4 Hz, 2H), 7.74 (d, J = 8.4 Hz, 2H), 7.43 (s, 2H), 7.26 (s, 1H), 4.12 (d, J = 17.3Hz, 1H), 3.94 (s, 3H), 3.74 (d, J = 17.3Hz, 1H).

Step 3; Preparation of 5- (3,5-dichlorophenyl) -3- [4- (hydroxymethyl) phenyl] -5-trifluoromethyl-4,5-dihydroisoxazole 4- [5- (3,5- To a solution of dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzoate (5.00 g) in tetrahydrofuran (50 ml) was added sodium borohydride (0.64 g), and the mixture was stirred at 50 ° C. 10 ml of methanol was added dropwise in 5 portions, and stirring was continued for 3 hours at the same temperature after completion of the dropwise addition. After completion of the reaction, the reaction mixture was poured into 70 ml of water, diluted to pH 3 with diluted hydrochloric acid, extracted with ethyl acetate (50 ml × 3), the organic layer was washed with water, saturated brine and then anhydrous sodium sulfate in this order, dried and dried. The solvent was distilled off under reduced pressure to obtain 5.00 g of a crude target product as a colorless resinous substance. This was used in the next step without further purification.
Melting point: 108.0-110.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.64 (d, J = 8.0Hz, 2H), 7.52 (d, J = 1.6Hz, 2H), 7.4-7.45 (m, 3H), 4.74 ( s, 2H), 4.09 (d, J = 17.2Hz, 1H), 3.71 (d, J = 17.2Hz, 1H), 1.93 (bs, 1H).

Step 4: Preparation of 3- [4- (chloromethyl) phenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 5- (3,5-dichlorophenyl)- To a solution of 4.2 g of 3- [4- (hydroxymethyl) phenyl] -5-trifluoromethyl-4,5-dihydroisoxazole in 100 ml of dichloromethane was added 1.2 ml of thionyl chloride and a catalytic amount (2 to 3 drops) of N, N-dimethylformamide was added, and the mixture was stirred for 3 hours with heating under reflux. After completion of the reaction, the reaction mixture was poured into 30 ml of ice water, and the organic layer was separated, washed with water (50 ml × 1) and then with a saturated aqueous sodium bicarbonate solution (30 ml × 3), dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and reduced pressure. The solvent was distilled off under. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 5) to obtain 4.1 g of the objective product as pale yellow crystals.
Melting point 98.0 to 100.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.65 (d, J = 7.8Hz, 2H), 7.51 (s, 2H), 7.4-7.5 (m, 3H), 4.59 (s, 2H), 4.08 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H).

Step 5: Preparation of N-[[4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] methyl] phthalimide 3- [4- (Chloromethyl) phenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 0.55 g of potassium phthalimide was added to a solution of 1.20 g of N, N-dimethylformamide in 20 ml. And stirred at room temperature for 20 hours. After completion of the reaction, the reaction mixture was diluted with 100 ml of ethyl acetate, washed with water (50 ml × 3), dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain 1.50 g of the desired product. Was obtained as white crystals.
Melting point: 190.0-192.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.8-7.95 (m, 2H), 7.7-7.8 (m, 2H), 7.55-7.65 (m, 2H), 7.35-7.5 (m, 5H) 4.90 (s, 2H), 4.05 (d, J = 17.6Hz, 1H), 3.65 (d, J = 17.6Hz, 1H).

Step 6: Production of 3- [4- (aminomethyl) phenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole (the present compound No. 9-001) N-[[4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] methyl] phthalimide in a 20 ml suspension of ethanol An 80% aqueous hydrazine monohydrate solution (1.0 ml) was added, and the mixture was stirred for 1.5 hours under reflux with heating. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, 50 ml of chloroform was added, insoluble matter was filtered off, and the solvent was distilled off under reduced pressure. The operation of adding 50 ml of chloroform to the residue to dissolve and dissolve insoluble matters and then distilling off the solvent under reduced pressure was repeated twice to obtain 1.1 g of the desired product as a yellow resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.61 (d, J = 8.1 Hz, 2H), 7.51 (s, 2H), 7.35-7.5 (m, 3H), 4.09 (d, J = 17.4 Hz, 1H), 3.93 (s, 2H), 3.68 (d, J = 17.4Hz, 1H).

  Step 7: Production of the compound of the present invention using L-COS (parallel liquid layer synthesizer from MRITEX).

The 13 L-COS reaction tubes containing the stirrer were capped and placed in the L-COS reaction vessel, and 3- [4- (aminomethyl) phenyl] -5- (3,5-dichlorophenyl) -5 -1 ml each of chloroform solution (0.26 mmol / ml) of trifluoromethyl-4,5-dihydroisoxazole and 1 ml each of chloroform solution of triethylamine (0.28 mmol / ml) were dispensed. Under stirring at room temperature, each reaction tube was charged with 4-chlorobenzoyl chloride, 3-chlorobenzoyl chloride, 2-chlorobenzoyl chloride, acetyl chloride, propionyl chloride, chloroacetyl chloride, phenyl chloroformate, chloroformate. Methyl acid, ethyl chloroformate, isobutyryl chloride, isobutyl chloroformate, methoxyacetyl chloride and cyclopropanecarbonyl chloride were each dispensed in 0.39 mmol, and stirring was continued at the same temperature for 24 hours. After completion of the reaction, 3 ml of cold water was added to each reaction tube, the organic layer was separated, and subjected to medium pressure preparative liquid chromatography (Yamazen Co., Ltd.) eluting directly with ethyl acetate-hexane (1:10 to 1: 1 gradient). The product was purified by a medium pressure fractionator (YFLC-Wprep). The product is LC-MS (Waters LC-MS system, detector; ZMD, analysis conditions; 254 nm, 83% CH ₃ CN-17% H ₂ O-0.1% HCOOH, ionization method; positive electrospray or negative electrospray) It confirmed using.

N- (4-chlorobenzoyl) -4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzylamine; 0.104 g, [M ⁺ -H] = 524.98.

N- (3-chlorobenzoyl) -4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzylamine; 0.111 g, [M ⁺ -H] = 524.98.

N- (2-chlorobenzoyl) -4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzylamine; 0.107 g, [M ⁺ + H] = 527.06.

N- acetyl-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl] ^{benzylamine; 0.044g, [M + + H} ] = 431.06 .

N- propionyl-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl] ^{benzylamine; 0.089g, [M + + H} ] = 445.13 .

N-chloroacetyl-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzylamine; 0.083 g, [M ⁺ -H] = 463.01.

N- [4- [5- (3,5- dichlorophenyl) -5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl] phenylmethyl] phenyl carbamate; 0.105g, [M ^{+ +} H ] = 509.09.

Methyl N- [4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenylmethyl] carbamate; 0.049 g, [M ⁺ + H ] = 447.14.

N- [4- [5- (3,5- dichlorophenyl) -5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl] phenyl methyl] carbamic acid ethyl; 0.101g, [M ^{+ +} H ] = 461.12.

N- isobutyryl-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl] ^{benzylamine; 0.087g, [M + + H} ] = 459.11 .

N- [4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenylmethyl] carbamate; 0.101 g, [M ⁺ + H ] = 489.17.

N- (2-methoxyacetyl) -4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzylamine; 0.079 g, [M ⁺ + H] = 461.10.

N- cyclopropyl-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl] ^{benzylamine; 0.087g, [M + + H} ] = 457.10.

Synthesis example 2
N-cyclopropylcarbonyl-1- [2-chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] ethylamine (invention) Compound No. 2-041).

Step 1: Preparation of 3-chloro-4-methylbenzaldoxime 4.7 g of hydroxylamine hydrochloride was added to a solution of 5.0 g of 3-chloro-4-methylbenzaldehyde in 40 ml of methanol and 30 ml of water, and at room temperature for 2 hours. Stir. After completion of the reaction, the reaction mixture was diluted with 70 ml of ethyl acetate, washed with water (30 ml × 1), dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. Obtained as white crystals. This product was directly used in the next step without further purification.
Melting point 66.0-68.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ8.12 (bs, 1H), 8.07 (s, 1H), 7.56 (s, 1H), 7.37 (d, J = 7.8Hz, 1H), 7.23 ( d, J = 7.8Hz, 1H), 2.39 (s, 3H).

Step 2: Preparation of 3- (3-Chloro-4-methylphenyl) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 3-Chloro-4-methylbenzald 9.2 g of N-chlorosuccinimide was added to a solution of 10.6 g of oxime in 60 ml of 1,2-dimethoxyethane and stirred at 70 ° C. for 2 hours. Next, the reaction mixture was allowed to cool to room temperature, 11.3 g of 3,5-dichloro-1- [1- (trifluoromethyl) ethenyl] benzene synthesized in Step 1 of Synthesis Example 1, 15.6 g of potassium bicarbonate and water 10 ml was added and stirring was continued for another 20 hours at room temperature. After completion of the reaction, the reaction mixture was diluted with 70 ml of ethyl acetate, washed with water (50 ml × 1), saturated brine and then anhydrous sodium sulfate in this order, dried and dried, and the solvent was distilled off under reduced pressure. The residual solid was washed with diisopropyl ether to obtain 13.8 g of the desired product as white crystals.
Melting point 97.0-99.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.62 (d, J = 1.5Hz, 1H), 7.49 (s, 2H), 7.47 (dd, J = 7.8, 1.5Hz, 1H), 7.42 ( t, J = 1.5Hz, 1H), 7.28 (d, J = 7.8Hz, 1H), 4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 2.41 (s, 3H).

Step 3: Preparation of 3- (4-bromomethyl-3-chlorophenyl) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 3- (3-Chloro-4-methyl Phenyl) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole in a solution of 13.7 g of 1,2-dichloroethane in 100 ml of 6.6 g of N-bromosuccinimide and α, α '-Azobisisobutyronitrile (0.1 g) was added, and the mixture was stirred at 70 ° C for 3 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, washed with water (70 ml × 2), dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residual solid was washed with diisopropyl ether to obtain 12.1 g of the desired product as pale yellow crystals.
Melting point 94.0-97.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.68 (d, J = 1.8Hz, 1H), 7.58 (dd, J = 8.1, 1.8Hz, 1H), 7.45-7.55 (m, 3H), 7.43 (t, J = 1.8Hz, 1H), 4.58 (s, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H).

Step 4: Preparation of 2-chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzyl acetate 3- (4-bromomethyl- 3-chlorophenyl) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole was added to a suspension of 7.9 g of acetic acid in 40 ml of acetic acid and 3.8 g of potassium acetate was added. And stirred for 2 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, diluted with 100 ml of chloroform, washed with water (50 ml × 2) and then with a saturated aqueous sodium hydrogen carbonate solution (50 ml × 4), then dehydrated with saturated brine and then anhydrous sodium sulfate. The solvent was distilled off under drying and reduced pressure. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 6) to obtain 6.4 g of the desired product as a colorless oil.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.68 (d, J = 1.8Hz, 1H), 7.58 (dd, J = 8.1, 1.8Hz, 1H), 7.45-7.55 (m, 3H), 7.43 (t, J = 1.8Hz, 1H), 5.22 (s, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H), 2.15 (s, 3H).

Step 5; Preparation of 3- [3-Chloro-4- (hydroxymethyl) phenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 2-Chloro-4- [5- (3,5-Dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzyl acetate in a solution of 6.4 g of ethanol in 20 ml of ethanol and 40 ml of water was added with 1.4 g of sodium hydroxide. The mixture was added and stirred at 100 ° C. for 1 hour. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, diluted with 80 ml of ethyl acetate and washed with water (40 ml × 2). The organic layer was dehydrated and dried in the order of saturated brine and anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. As a result, 4.5 g of the desired product was obtained as yellow crystals.
Melting point 32.0-35.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.68 (d, J = 1.8Hz, 1H), 7.55-7.65 (m, 2H), 7.50 (d, J = 1.8Hz, 2H), 7.43 ( t, J = 1.8Hz, 1H), 4.81 (s, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H).

Step 6; Preparation of 2-chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzaldehyde 3- [3-Chloro-4- (Hydroxymethyl) phenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole in 2.0 ml of dichloromethane was added to 4.0 g of silica gel and 1.3 g of pyridinium chlorochromate. And stirred at room temperature for 20 hours. After completion of the reaction, the solid was filtered off through a glass filter filled with silica gel, and the solvent was distilled off under reduced pressure. The residual solid was washed with diisopropyl ether to obtain 1.45 g of the desired product as pale yellow crystals.
Melting point: 129.0-133.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ 10.48 (s, 1H), 7.98 (d, J = 7.8Hz, 1H), 7.77 (s, 1H), 7.68 (d, J = 7.8Hz, 1H), 7.50 (s, 2H), 7.44 (s, 1H), 4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H).

Step 7; Preparation of 3- [3-Chloro-4- (1-hydroxyethyl) phenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole under nitrogen atmosphere 2-Chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzaldehyde was stirred at room temperature in a solution of 1.4 g of diethyl ether in 50 ml of diethyl ether. Then, 6.6 ml of a tetrahydrofuran solution of methylmagnesium bromide (0.87 mol / L) was added dropwise. After completion of the dropwise addition, stirring was continued for 30 minutes under heating and reflux. After completion of the reaction, 5 ml of aqueous ammonium chloride solution was added to the reaction mixture with stirring under ice cooling, extracted with ethyl acetate (50 ml × 1), the organic layer was washed with water (30 ml × 2), dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 1.5 g of the desired product as a pale yellow resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.55-7.75 (m, 3H), 7.50 (d, J = 1.5Hz, 2H), 7.43 (t, J = 1.5Hz, 1H), 5.29 ( q, J = 6.3Hz, 1H), 4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 1.48 (d, J = 6.3Hz, 3H).

Step 8; Preparation of 3- [3-chloro-4- (1-chloroethyl) phenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 3- [3- Chloro-4- (1-hydroxyethyl) phenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole in a solution of 0.96 g of dichloromethane in 0.2 ml of thionyl chloride and A catalytic amount (2 to 3 drops) of N, N-dimethylformamide was added and stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was poured into 20 ml of ice water, and the organic layer was separated, washed with water (20 ml × 1) and then with a saturated aqueous sodium hydrogen carbonate solution (20 ml × 3), then dehydrated, dried and dried under reduced pressure in the order of saturated brine and anhydrous sodium sulfate. Under reduced pressure, the solvent was distilled off to obtain 0.88 g of the desired product as a yellow oily substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.55-7.75 (m, 3H), 7.50 (s, 2H), 7.43 (s, 1H), 5.52 (q, J = 6.3Hz, 1H), 4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 1.82 (d, J = 6.3Hz, 3H).

Step 9; of N- [1- [2-Chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] ethyl] phthalimide Preparation 3- [3-Chloro-4- (1-chloroethyl) phenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 0.88 g N, N-dimethyl 0.35 g of potassium phthalimide was added to a 5 ml solution of formamide and stirred at 100 ° C. for 1.5 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, diluted with 20 ml of ethyl acetate, washed with water (10 ml × 3), dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Co., Ltd. medium pressure preparator; YFLC-Wprep) eluting with ethyl acetate-hexane (1:10 to 1: 3 gradient). 0.45 g was obtained as a pale yellow resinous material.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.75-7.9 (m, 3H), 7.55-7.75 (m, 4H), 7.49 (d, J = 1.5Hz, 2H), 7.42 (d, J = 1.5Hz, 1H), 5.83 (q, J = 7.2Hz, 1H), 4.03 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H), 1.86 (d, J = 7.2 Hz, 3H).

Step 10; 3- [4- (1-aminoethyl) -3-chlorophenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole (Compound No. 9 of the present invention) -016) N- [1- [2-Chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] ethyl] To a solution of 0.40 g of phthalimide in 10 ml of ethanol was added 1.0 ml of an 80% hydrazine monohydrate aqueous solution, and the mixture was stirred for 1 hour while heating under reflux. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, 20 ml of chloroform was added, insolubles were filtered off, and the solvent was distilled off under reduced pressure. The operation of adding 20 ml of chloroform to the residue to dissolve and dissolve insoluble matters and then evaporating the solvent under reduced pressure was repeated twice to obtain 0.26 g of the desired product as a yellow resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.5-7.7 (m, 3H), 7.51 (d, J = 1.5Hz, 2H), 7.43 (t, J = 1.5Hz, 1H), 4.56 ( q, J = 6.6Hz, 1H), 4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 1.37 (d, J = 6.6Hz, 3H).

Step 11; N-cyclopropylcarbonyl-1- [2-chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] ethylamine Preparation of 3- [4- (1-aminoethyl) -3-chlorophenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 0.22 g and triethylamine 0.07 g 0.08 g of cyclopropanecarbonyl chloride was added dropwise to a solution of 1.5 ml of chloroform under ice cooling and stirring was continued for another 20 minutes at room temperature. After completion of the reaction, 1 ml of water was added to the reaction mixture, the organic layer was separated, and subjected to medium pressure preparative liquid chromatography (Yamazen Co., Ltd., medium pressure) eluting with ethyl acetate-hexane (1: 8 to 1: 1 gradient) as it was. Purification by a preparative apparatus; YFLC-Wprep) gave 0.14 g of the desired product as a colorless resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.5-7.65 (m, 2H), 7.49 (d, J = 1.5Hz, 2H), 7.43 (t, J = 1.5Hz, 1H), 7.39 ( d, J = 8.1Hz, 1H), 6.12 (d, J = 6.6Hz, 1H), 5.3-5.45 (m, 1H), 4.04 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4 Hz, 1H), 1.48 (d, J = 6.9 Hz, 3H), 1.35-1.45 (m, 1H), 0.70-1.05 (m, 4H).

Synthesis example 3
1-cyano-N-cyclopropylcarbonyl-1- [2-chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] Methylamine (the present compound No. 2-042).

Step 1; 1-amino-1- [2-chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] acetonitrile (present Preparation of Invention Compound No. 9-017) 2-Chloro-4- [5- (5) synthesized in Step 6 of Synthesis Example 2 was added to a solution of 0.18 g of sodium cyanide and 0.29 g of ammonium chloride in 5 ml of 28% aqueous ammonia. 3,5-Dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzaldehyde (1.0 g) in 30 ml of methanol was added, and the mixture was stirred at 60 ° C. for 2 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, diluted with 60 ml of ethyl acetate and washed with water (30 ml × 2). The organic layer was dehydrated and dried in the order of saturated brine and anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. 1.10 g of the desired product was obtained as a light brown resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.7-7.8 (m, 3H), 7.50 (s, 2H), 7.44 (t, J = 1.5Hz, 1H), 5.25 (t, J = 7.8 Hz, 1H), 4.06 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H).

Step 2; 1-cyano-N-cyclopropylcarbonyl-1- [2-chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl Preparation of phenyl] methylamine 1-amino-1- [2-chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl ] To a 1.5 ml chloroform solution of 0.20 g of acetonitrile and 0.06 g of triethylamine, 0.06 g of cyclopropanecarbonyl chloride was added dropwise with stirring under ice cooling, and stirring was continued for another 30 minutes at room temperature. After completion of the reaction, 1 ml of water was added to the reaction mixture, the organic layer was separated, and subjected to medium pressure preparative liquid chromatography (Yamazen Co., Ltd., medium pressure) eluting with ethyl acetate-hexane (1: 8 to 1: 1 gradient) as it was. Purification by a preparative apparatus; YFLC-Wprep) gave 0.14 g of the desired product as a colorless resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.75-7.8 (m, 1H), 7.72 (d, J = 8.1 Hz, 1H), 7.6-7.65 (m, 1H), 7.50 (d, J = 1.5Hz, 2H), 7.44 (t, J = 1.5Hz, 1H), 6.52 (d, J = 8.1Hz, 1H), 6.30 (d, J = 7.2Hz, 1H), 4.07 (d, J = 17.4 Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 1.35-1.5 (m, 1H), 0.80-1.15 (m, 4H).

Synthesis example 4
N-isobutyryl-1- [2-chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] -2,2,2 -Trifluoroethylamine (the present compound No. 2-026).

Step 1: Preparation of N-isobutyryl-1- (4-bromophenyl) -2,2,2-trifluoroethylamine 1.10 g of 1- (4-bromophenyl) -2,2,2-trifluoroethylamine hydrochloride Then, 0.43 g of isobutyryl chloride was added to 20 ml of a chloroform suspension of 0.79 g of triethylamine with stirring under ice cooling, and the mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was washed with 20 ml of water and then with 20 ml of saturated aqueous sodium hydrogen carbonate solution, the organic layer was dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. 1.30 g was obtained as white crystals.
Melting point 176.0-178.0 ° C.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300MHz) δ7.53 (d, J = 8.1Hz, 2H), 7.25 (d, J = 8.1Hz, 2H), 6.20 (d, J = 9.0Hz, 1H) , 5.6-5.75 (m, 1H), 2.4-2.5 (m, 1H), 1.20 and 1.15 (d, J = 6.6Hz, 6H).

Step 2; Preparation of N-isobutyryl-2,2,2-trifluoro-1- (4-formylphenyl) ethylamine N-isobutyryl-1- (4-bromophenyl) -2,2,2-tri in an autoclave To a solution of 0.51 g of fluoroethylamine and 0.16 g of sodium formate in 10 ml of N, N-dimethylformamide was added 0.065 g of dichlorobis (triphenylphosphine) palladium (II), and the mixture was heated to 120 ° C. under a carbon monoxide atmosphere of 1.5 MPa. And stirred for 1.5 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, diluted with 50 ml of ethyl acetate and washed with water (50 ml × 2). The organic layer was dehydrated and dried in the order of saturated brine and anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. . The residue was purified by medium pressure preparative liquid chromatography (Yamazen Co., Ltd. medium pressure preparator; YFLC-Wprep) eluting with ethyl acetate-hexane (1: 3 to 1: 1 gradient). 0.18 g was obtained as white crystals.
Melting point: 132.0-133.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ10.04 (s, 1H), 7.93 (d, J = 7.8 Hz, 2H), 7.70 (d, J = 7.8 Hz, 2H), 6.15 (d, J = 9.0Hz, 1H), 5.75-5.9 (m, 1H), 2.4-2.55 (m, 1H), 1.22 and 1.17 (d, J = 6.9Hz, 6H).

Step 3: Production of N-isobutyryl-2,2,2-trifluoro-1- [4- (hydroxyiminomethyl) phenyl] ethylamine N-isobutyryl-2,2,2-trifluoro-1- (4-formyl To a solution of 0.16 g of phenyl) ethylamine in 4.0 ml of methanol and 1.0 ml of water, 0.075 g of hydroxylamine hydrochloride was added and stirred at room temperature for 1.5 hours. After completion of the reaction, the reaction mixture was diluted with 20 ml of ethyl acetate and washed with water (10 ml × 1). The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate. 20 g was obtained as white crystals.
Melting point 169.0 to 171.0 ° C
¹ H NMR (CDCl ₃ -DMSO-d ₆ , Me ₄ Si, 300 MHz) δ 10.23 (s, 1H), 8.11 (s, 1H), 7.60 (d, J = 8.1Hz, 2H), 7.43 (d, J = 8.1Hz, 2H), 7.1-7.3 (m, 1H), 5.65-5.85 (m, 1H), 2.45-2.6 (m, 1H), 1.19 and 1.12 (d, J = 6.9Hz, 6H).

Step 4; N-isobutyryl-1- [2-chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] -2, Preparation of 2,2-trifluoroethylamine N-isobutyryl-2,2,2-trifluoro-1- [4- (hydroxyiminomethyl) phenyl] ethylamine in a solution of 0.14 g of 1,2-dimethoxyethane in 10 ml of N- 0.086 g of chlorosuccinimide was added and stirred at 80 ° C. for 1 hour. The reaction mixture was then allowed to cool to room temperature, 0.14 g of 3,5-dichloro-1- [1- (trifluoromethyl) ethenyl] benzene synthesized in Step 1 of Synthesis Example 1 and 0.074 g of potassium bicarbonate and water. Three drops were added and stirring was continued for an additional 15 hours at room temperature. After completion of the reaction, the reaction mixture was diluted with 30 ml of ethyl acetate and washed with water (10 ml × 1). The organic layer was dehydrated and dried in the order of saturated brine and anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Co., Ltd. medium pressure preparator; YFLC-Wprep) eluting with ethyl acetate-hexane (1: 3 to 1: 1 gradient). 0.044 g was obtained as a colorless resinous material.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300MHz) δ7.69 (d, J = 8.1Hz, 2H), 7.4-7.55 (m, 5H), 6.32 (d, J = 9.3Hz, 1H), 5.75- 5.85 (m, 1H), 4.08 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H), 2.4-2.55 (m, 1H), 1.20 and 1.15 (d, J = 6.9Hz , 6H).

Synthesis example 5
N-cyclopropylcarbonyl-1- [4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] -1- (phenyl) methylamine (Invention compound No. 2-060).

A solution of 0.80 g of 4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzonitrile in 10 ml of tetrahydrofuran under nitrogen atmosphere was stirred at room temperature. Then, 1.0 ml of a 32% tetrahydrofuran solution of phenylmagnesium bromide was added dropwise, and after completion of the dropwise addition, stirring was continued for another 3.5 hours at room temperature. After completion of the reaction, the solvent was distilled off under reduced pressure, the residue was dissolved in 10 ml of methanol, 0.075 g of sodium borohydride was added, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with 20 ml of ethyl acetate and washed with water (10 ml × 2). The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was dissolved in chloroform (20 ml), and triethylamine (0.20 g) and cyclopropanecarbonyl chloride (0.21 g) were added dropwise with stirring under ice-cooling. After completion of the reaction, the reaction mixture was washed with water (10 ml × 1), the organic layer was dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Corporation medium pressure preparative device; YFLC-Wprep) eluting with ethyl acetate-hexane (1: 9 to 1: 2 gradient). 0.16 g was obtained as a colorless resinous material.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.62 (d, J = 8.1Hz, 2H), 7.50 (s, 2H), 7.42 (t, J = 1.5Hz, 1H), 7.25-7.4 ( m, 5H), 7.15-7.25 (m, 2H), 6.15-6.3 (m, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 1.35-1.5 (m, 1H), 0.95-1.05 (m, 2H), 0.75-0.85 (m, 2H).

Synthesis Example 6
N- (2,4,6-trifluorobenzoyl) -1- [4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] Cyclopropylamine (the present compound No. 8-018).

Step 1; Preparation of 3- [4- (1-aminocyclopropyl) phenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 4- [under nitrogen atmosphere To a solution of 3.0 g of 5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzonitrile and 4.4 g of titanium tetraisopropoxide in 100 ml of tetrahydrofuran was added -78. 7.8 ml of a 3.0 M diethyl ether solution of ethylmagnesium bromide was added dropwise with stirring at ° C. After completion of the dropwise addition, stirring was continued for 1 hour at room temperature. Then, 4.4 g of boron trifluoride diethyl ether complex was added to the reaction mixture, and stirring was further continued for 20 hours at the same temperature. After completion of the reaction, 30 ml of 1N hydrochloric acid aqueous solution was added to the reaction mixture and stirred for 10 minutes, and then the mixture was made basic by adding 50 ml of 1N aqueous sodium hydroxide solution and extracted with 100 ml of ethyl acetate. The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, and the residue was eluted with ethyl acetate-hexane (1: 4 to 1: 0 gradient). Purification by column chromatography gave 0.9 g of the desired product as a yellow resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.3-7.65 (m, 7H), 4.05 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H), 1.1- 1.2 (m, 2H), 1.0-1.05 (m, 2H).

Step 2: N- (2,4,6-trifluorobenzoyl) -1- [4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl Preparation of phenyl] cyclopropylamine 0.15 g of 3- [4- (1-aminocyclopropyl) phenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole In a 5 ml solution of dichloromethane, 0.08 g of 2,4,6-trifluorobenzoic acid, 0.10 g of 1- [3- (diethylamino) propyl] -3-ethylcarbodiimide hydrochloride, 0.11 g of triethylamine and 4- (N, N -Dimethylamino) pyridine 0.01 g was added and stirred at room temperature for 12 hours. After completion of the reaction, 10 ml of water was added to the reaction mixture, extracted with 30 ml of ethyl acetate, the organic layer was washed with 10 ml of water, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. Left. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 1) to obtain 0.03 g of the desired product as a colorless resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300MHz) δ7.60 (d, J = 8.4Hz, 2H), 7.50 (s, 2H), 7.41 (s, 1H), 7.33 (d, J = 8.4Hz, 2H), 6.73 (t, J = 8.1Hz, 2H), 6.62 (s, 1H), 4.05 (d, J = 17.1Hz, 1H), 3.65 (d, J = 17.1Hz, 1H), 1.35-1.5 ( m, 4H).

Synthesis example 7
N-butyryl-2-chloro-4- [5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzylamine (Compound No. 1 of the present invention) 2-111).

Step 1: Production of 3,4,5-trichloro-1-iodobenzene To a suspension of 2,5.0 g of 3,4,5-trichloroaniline in 10 ml of acetonitrile, 25 ml of methanol and 100 ml of water, nitrous acid is stirred under ice-cooling. A solution of sodium 9.7 g in 25 ml of water was added dropwise over 20 minutes. After completion of the addition, the mixture was stirred at 5-6 ° C. for 30 minutes. The reaction mixture was then added dropwise to 75 ml of an aqueous solution of 23.2 g of potassium iodide heated to 80 ° C. over 20 minutes. After completion of the addition, stirring was continued for an additional hour at the same temperature. After completion of the reaction, 50 ml of an aqueous solution of 7.64 g of urea was added to the reaction mixture, allowed to cool to room temperature with stirring, diluted with 400 ml of ethyl acetate, and insolubles were filtered off through Celite filtration. The organic layer was washed with 300 ml of a saturated aqueous sodium hydrogensulfite solution and then with 200 ml of water, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography eluting with hexane to obtain 29.3 g of the desired product as pale yellow crystals.
Melting point: 45.0-46.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ 7.70 (s, 2H).

Step 2: Production of 3,4,5-trichloro-1- [1- (trifluoromethyl) ethenyl] benzene 1M tetrahydrofuran solution of 1- (trifluoromethyl) ethenylzinc bromide prepared according to the method described in the literature To 190 ml, 29.2 g of 3,4,5-trichloro-1-iodobenzene and 2.66 g of dichlorobis (triphenylphosphine) palladium (II) were added and stirred for 3 hours under heating and reflux. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, 350 ml of hexane was added, the precipitated insoluble matter was filtered off, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography eluting with hexane to obtain 24.3 g of the desired product as a brown oily substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ 7.47 (s, 2H), 6.06 (s, 1H), 5.83 (s, 1H).

Step 3; Preparation of 3- (3-chloro-4-methylphenyl) -5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole Step 1 of Synthesis Example 2 9.1 g of N-chlorosuccinimide was added to 50 ml of 1,2-dimethoxyethane in 10.5 g of 3-chloro-4-methylbenzaldoxime synthesized in 1 above and stirred at 70 ° C. for 2 hours. The reaction mixture was then allowed to cool to room temperature, 17.0 g of 3,4,5-trichloro-1- [1- (trifluoromethyl) ethenyl] benzene, 9.3 g of potassium bicarbonate and 10 ml of water were added, and further at room temperature. Stirring was continued for 16 hours. After completion of the reaction, the reaction mixture was diluted with 200 ml of ethyl acetate, washed with water (70 ml × 1), saturated brine and then anhydrous sodium sulfate in this order, dried and dried, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 5) to obtain 26.2 g of the desired product as a brown resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.64 (s, 2H), 7.62 (d, J = 1.5Hz, 1H), 7.47 (dd, J = 8.1, 1.5Hz, 1H), 7.29 ( d, J = 8.1Hz, 1H), 4.06 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 2.41 (s, 3H).

Step 4: Preparation of 3- (4-bromomethyl-3-chlorophenyl) -5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 3- (3-Chloro- 4-methylphenyl) -5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole in a solution of 26.2 g of 1,2-dichloroethane in 200 ml of N-bromosuccinimide 12 0.1 g and α, α′-azobisisobutyronitrile (0.81 g) were added, and the mixture was stirred at 80 ° C. for 3 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, washed with water (70 ml × 2), dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. Obtained as a brown oil. This was used in the next step without further purification.

Step 5; N-[[2-Chloro-4- [5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] methyl] phthalimide 3- (4-Bromomethyl-3-chlorophenyl) -5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 34.1 g of N, N-dimethylformamide To the 200 ml solution, 12.6 g of potassium phthalimide was added and stirred at room temperature for 3 hours. After completion of the reaction, the reaction mixture was diluted with 350 ml of ethyl acetate, washed with water (80 ml × 3), dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 3) to obtain 24.3 g of the desired product as a pale yellow resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.85-7.95 (m, 2H), 7.75-7.8 (m, 2H), 7.67 (d, J = 1.5Hz, 1H), 7.62 (s, 2H ), 7.50 (dd, J = 7.8, 1.5Hz, 1H), 7.28 (d, J = 7.8Hz, 1H), 5.00 (s, 2H), 4.03 (d, J = 17.4Hz, 1H), 3.64 (d , J = 17.4Hz, 1H).

Step 6; 3- (4-Aminomethyl-3-chlorophenyl) -5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole (Compound No. 9- of the present invention) N-[[2-Chloro-4- [5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] methyl] To a solution of phthalimide (3.0 g) in ethanol (70 ml) was added 80% hydrazine monohydrate aqueous solution (1.0 ml), and the mixture was stirred for 1 hour with heating under reflux. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, 100 ml of chloroform was added, insoluble matter was filtered off, and the solvent was distilled off under reduced pressure. Chloroform 50 ml was added to the residue to dissolve and insoluble matter was filtered off. The filtrate was washed with water (50 ml × 1), then dehydrated and dried in the order of saturated brine and anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. 2.55 g of product was obtained as a yellow resinous material.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.66 (d, J = 1.5Hz, 1H), 7.64 (s, 2H), 7.56 (dd, J = 7.8, 1.5Hz, 1H), 7.50 ( d, J = 7.8Hz, 1H), 4.07 (d, J = 17.4Hz, 1H), 3.98 (s, 2H), 3.67 (d, J = 17.4Hz, 1H).

Step 7: Preparation of N-butyryl-2-chloro-4- [5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzylamine 3 -(4-Aminomethyl-3-chlorophenyl) -5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 85 mg triethylamine 28 mg Under stirring, 30 mg of butyric chloride was added dropwise, and after completion of the addition, stirring was continued for an additional 1.5 hours at room temperature. After completion of the reaction, 1 ml of saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, the organic layer was separated, and eluted with ethyl acetate-hexane (1: 4 to 1: 1 gradient) as it was, with medium pressure preparative liquid chromatography (Yamazen) The product was purified with a medium pressure fractionator (YFLC-Wprep) to obtain 99 mg of the desired product as a colorless resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.67 (d, J = 1.5Hz, 1H), 7.63 (s, 2H), 7.50 (dd, J = 7.8, 1.5Hz, 1H), 7.45 ( d, J = 7.8Hz, 1H), 5.96 (bs, 1H), 4.53 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 2.20 (t, J = 7.2Hz, 2H), 1.6-1.75 (m, 2H), 0.94 (t, J = 7.2Hz, 3H).

Synthesis example 8
2-chloro-N-cyclopropylcarbonyl-4- [5- [3,5-bis (trifluoromethyl) phenyl] -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzylamine ( Compound No. 2-081 of the present invention.

Step 1: Preparation of N-[(2-chloro-4-iodophenyl) methyl] phthalimide Potassium phthalimide in a solution of 7.6 g of 1-bromomethyl-2-chloro-4-iodobenzene in 50 ml of N, N-dimethylformamide 7 g was added and stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was diluted with 80 ml of ethyl acetate, washed with water (30 ml × 2), dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate. Obtained as white crystals.
Melting point: 140.0-142.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.85-7.9 (m, 2H), 7.7-7.8 (m, 3H), 7.51 (dd, J = 8.1, 1.5Hz, 1H), 6.95 (d , J = 8.1Hz, 1H), 4.92 (s, 2H).

Step 2: Preparation of 2-chloro-4-iodobenzylamine 3.0 ml of 80% hydrazine monohydrate solution was added to a solution of 2.9 g of N-[(2-chloro-4-iodophenyl) methyl] phthalimide in 60 ml of ethanol. The mixture was added and stirred at 70 ° C for 30 minutes. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, 100 ml of chloroform was added, insoluble matter was filtered off, and the solvent was distilled off under reduced pressure. The operation of adding 30 ml of chloroform to the residue to dissolve and dissolve insoluble matters and then evaporating the solvent under reduced pressure was repeated twice to obtain 2.8 g of the desired product as a yellow oily substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300MHz) δ7.70 (d, J = 1.5Hz, 1H), 7.58 (d, J = 8.1Hz, 1H), 7.13 (d, J = 8.1Hz, 1H) , 3.89 (s, 2H).

Step 3; Preparation of 2-chloro-N-cyclopropylcarbonyl-4-iodobenzylamine To 25 ml of a chloroform suspension of 2.80 g of 2-chloro-4-iodobenzylamine and 0.76 g of triethylamine, with ice-cooling and stirring, Cyclopropanecarbonyl chloride (0.77 g) was added, and the mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was washed with 20 ml of a saturated aqueous sodium hydrogen carbonate solution and then with 20 ml of water. The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. 2.20 g was obtained as white crystals.
Melting point 158.0 to 160.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300MHz) δ7.72 (d, J = 1.5Hz, 1H), 7.55 (d, J = 8.1Hz, 1H), 7.13 (d, J = 8.1Hz, 1H) , 6.05 (bs, 1H), 4.47 (d, J = 6.0Hz, 2H), 1.3-1.4 (m, 1H), 0.95-1.05 (m, 2H), 0.7-0.8 (m, 2H).

Step 4: Preparation of 2-chloro-N-cyclopropylcarbonyl-4-formylbenzylamine 2.20 g of 2-chloro-N-cyclopropylcarbonyl-4-iodobenzylamine and 0.57 g of sodium formate in an autoclave To a 20 ml solution of N-dimethylformamide was added 0.26 g of dichlorobis (triphenylphosphine) palladium (II), and the mixture was stirred for 1 hour at 90 ° C. in a carbon monoxide atmosphere of 1.5 MPa. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, diluted with 60 ml of ethyl acetate and washed with water (30 ml × 2). . The residue was purified by silica gel column chromatography eluting with ethyl acetate to obtain 1.20 g of the desired product as white crystals.
Melting point: 143.0-145.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300MHz) δ9.96 (s, 1H), 7.88 (d, J = 1.5Hz, 1H), 7.74 (dd, J = 8.1, 1.5Hz, 1H), 7.57 ( d, J = 8.1Hz, 1H), 6.13 (bs, 1H), 4.50 (d, J = 6.3Hz, 2H), 1.35-1.45 (m, 1H), 0.95-1.05 (m, 2H), 0.75-0.85 (m, 2H).

Step 5: Preparation of 2-chloro-N-cyclopropylcarbonyl-4- (hydroxyiminomethyl) benzylamine 2-Chloro-N-cyclopropylcarbonyl-4-formylbenzylamine 1.20 g in 40 ml methanol and 10 ml water Hydroxylamine hydrochloride (0.50 g) was added, and the mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was diluted with 50 ml of ethyl acetate and washed with water (30 ml × 1). The organic layer was dehydrated and dried in the order of saturated brine and anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. 95 g were obtained as white crystals.
Melting point: 163.0 to 166.0 ° C
¹ H NMR (CDCl ₃ -DMSO-d ₆ , Me ₄ Si, 300 MHz) δ11.40 (s, 1H), 8.60 (t, J = 5.7 Hz, 1H), 8.11 (s, 1H), 7.62 (s, 1H), 7.55 (d, J = 8.1Hz, 1H), 7.33 (d, J = 8.1Hz, 1H), 4.32 (d, J = 5.7Hz, 2H), 1.6-1.7 (m, 1H), 0.65- 0.7 (m, 4H).

Step 6; Preparation of 2-chloro-4- (chlorohydroxyiminomethyl) -N- (cyclopropylcarbonyl) benzylamine 0.45 g of 2-chloro-N-cyclopropylcarbonyl-4- (hydroxyiminomethyl) benzylamine To a 20 ml solution of 1,2-dimethoxyethane, 0.29 g of N-chlorosuccinimide was added and stirred at 70 ° C. for 1.5 hours. After completion of the reaction, the reaction mixture was diluted with 50 ml of ethyl acetate and washed with water (10 ml × 1). The organic layer was dehydrated and dried in the order of saturated brine and anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. 55 g was obtained as a yellow resinous material. This product was directly used in the next reaction without further purification.

Step 7; 2-Chloro-N-cyclopropylcarbonyl-4- [5- [3,5-bis (trifluoromethyl) phenyl] -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] Preparation of benzylamine Synthesized in Reference Example 2 in a solution of 0.15 g of 2-chloro-4- (chlorohydroxyiminomethyl) -N- (cyclopropylcarbonyl) benzylamine in 4.0 ml of 1,2-dimethoxyethane 3 , 5-bis (trifluoromethyl) -1- [1- (trifluoromethyl) ethenyl] benzene 0.13 g, potassium hydrogen carbonate 0.080 g and 3 drops of water were added, and the mixture was stirred at room temperature for 15 hours. After completion of the reaction, the reaction mixture was diluted with 5 ml of ethyl acetate and washed with water (2 ml × 1). The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Co., Ltd. medium pressure preparator; YFLC-Wprep) eluting with ethyl acetate-hexane (1: 3 to 1: 1 gradient). 0.037 g was obtained as white crystals.
Melting point 158.0 to 160.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ8.07 (s, 2H), 7.97 (s, 1H), 7.70 (d, J = 1.5 Hz, 1H), 7.53 (dd, J = 8.1, 1.5 Hz, 1H), 7.47 (d, J = 8.1Hz, 1H), 6.10 (bs, 1H), 4.55 (d, J = 6.3Hz, 2H), 4.16 (d, J = 17.4Hz, 1H), 3.71 ( d, J = 17.4Hz, 1H), 1.35-1.45 (m, 1H), 0.95-1.05 (m, 2H), 0.75-0.8 (m, 2H).

Synthesis Example 9
2-Cyano-N-cyclopropylcarbonyl-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzylamine (Compound No. 2 of the present invention) -131).

Step 1; N- (cyclopropylcarbonyl) -N-[[4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -2-iodo Preparation of phenyl] methyl] carbamic acid-tert-butyl (the present compound No. 7-033) N-cyclopropylcarbonyl-4- [5- (3,5-dichlorophenyl)-synthesized in the same manner as in Synthesis Example 7 5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -2-iodobenzylamine (present compound No. 1-096) 0.98 g, triethylamine 0.17 g and 4- (N, N- To a solution of 0.02 g of (dimethylamino) pyridine in 10 ml of dichloromethane was added 0.73 g of di-tert-butyl dicarbonate, and the mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reaction mixture was diluted with 50 ml of dichloromethane, washed with water (30 ml × 1), dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Co., Ltd. medium pressure preparator; YFLC-Wprep) eluting with ethyl acetate-hexane (1:10 to 1: 4 gradient). 0.52 g was obtained as a white resinous material.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ8.07 (d, J = 1.5 Hz, 1H), 7.61 (d, J = 8.1 Hz, 1H), 7.50 (s, 2H), 7.4-7.45 ( m, 1H), 6.98 (d, J = 8.1Hz, 1H), 4.86 (s, 2H), 4.03 (d, J = 17.7Hz, 1H), 3.64 (d, J = 17.7Hz, 1H), 2.9- 3.0 (m, 1H), 1.38 (s, 9H), 1.1-1.2 (m, 2H), 0.65-1.05 (m, 2H).

Step 2; N-[[2-cyano-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] methyl] -N- ( Preparation of cyclopropylcarbonyl) carbamic acid-tert-butyl (the present compound No. 7-034) N- (cyclopropylcarbonyl) -N-[[4- [5- (3,5-dichlorophenyl) -5-tri To a solution of 0.49 g of fluoromethyl-4,5-dihydroisoxazol-3-yl] -2-iodophenyl] methyl] carbamic acid tert-butyl in 20 ml of N, N-dimethylacetamide, 0.09 g of zinc cyanide, 0.01 g of zinc, 0.03 g of tris (dibenzylideneacetone) dipalladium and 0.03 g of 1,1′-bis (diphenylphosphino) ferrocene were added, and the mixture was stirred at 110 ° C. for 1.5 hours under a nitrogen atmosphere. . After completion of the reaction, the reaction mixture was allowed to cool to room temperature, diluted with 60 ml of ethyl acetate, washed with water (50 ml × 1), saturated brine and then anhydrous magnesium sulfate in this order, dried and dried, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Corporation medium pressure preparative device; YFLC-Wprep) eluting with ethyl acetate-hexane (1:10 to 1: 4 gradient). 0.28 g was obtained as a pale yellow resinous material.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.87 (s, 1H), 7.49 (s, 2H), 7.4-7.45 (m, 2H), 7.29 (d, J = 7.8Hz, 1H), 5.12 (s, 2H), 4.06 (d, J = 17.7Hz, 1H), 3.67 (d, J = 17.7Hz, 1H), 2.85-2.95 (m, 1H), 1.41 (s, 9H), 1.1-1.2 (m, 2H), 0.95-1.05 (m, 2H).

Step 3; Preparation of 2-cyano-N-cyclopropylcarbonyl-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzylamine N- [[2-Cyano-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] methyl] -N- (cyclopropylcarbonyl) carbamide To a solution of 0.25 g of acid-tert-butyl in 4 ml of dichloromethane was added 0.4 ml of trifluoroacetic acid, and the mixture was stirred at room temperature for 3 hours. After completion of the reaction, the solvent was distilled off under reduced pressure, and the residue was eluted with ethyl acetate-hexane (1: 2 to 1: 1 gradient). The product was purified by YFLC-Wprep) to obtain 0.19 g of the desired product as a colorless resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300MHz) δ7.91 (d, J = 1.5Hz, 1H), 7.83 (dd, J = 8.1, 1.5Hz, 1H), 7.62 (d, J = 8.1Hz, 1H), 7.48 (d, J = 1.5Hz, 2H), 7.43 (t, J = 1.5Hz, 1H), 6.32 (t, J = 6.0Hz, 1H), 4.62 (d, J = 6.3Hz, 2H) , 4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 1.35-1.45 (m, 1H), 0.95-1.05 (m, 2H), 0.75-0.85 (m, 2H ).

Synthesis Example 10
Production of the compound of the present invention using L-COS (parallel liquid layer synthesizer from MRITEX).

In 15 L-COS reaction tubes containing stirrers, 4-fluorophenyl boric acid, 2-chlorophenyl boric acid, 3-chlorophenyl boric acid, 4-chlorophenyl boric acid, 2-methylphenyl boric acid, 3-methyl Phenyl boric acid, 4-methylphenyl boric acid, 3-cyanophenyl boric acid, 4-cyanophenyl boric acid, 3-aminophenyl boric acid, 3-acetamidophenyl boric acid, 4- (dimethylamino) phenyl boric acid, 1- 0.29 mmol each of naphthyl boric acid, 2-thienyl boric acid and 6-chloro-3-pyridyl boric acid was weighed, then 0.009 mmol of palladium (II) acetate and 0.5 ml of water were added to each reaction tube, and after nitrogen filling The lid was capped and installed in the L-COS reactor. 4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl synthesized in the same manner as in Synthesis Example 7 in each reaction tube under stirring at room temperature. ] -2-Iodo-N- (propionyl) benzylamine (the present compound No. 2-046) in tetrahydrofuran (0.097 mmol / ml) 2.0 ml each, triethylamine in tetrahydrofuran (1.50 mmol / ml) 0 0.5 ml and a solution of tris (2-methylphenyl) phosphine in tetrahydrofuran (0.039 mmol / ml) in the order of 0.5 ml were dispensed in this order and stirred at 75 ° C. for 3 hours. After completion of the reaction, each reaction tube was diluted with 3 ml of ethyl acetate and washed with water. The organic layer was dehydrated with saturated brine, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Co., Ltd. medium pressure preparative device; YFLC-Wprep) eluting with ethyl acetate-hexane (1:10 to 1: 1 gradient). Got. The product was obtained using LC-MS (Waters LC-MS system, detector; ZMD, analysis condition; 254 nm, 83% CH ₃ CN-17% H ₂ O-0.1% HCOOH, ionization method; positive electrospray). confirmed.

5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -4'-fluoro-N- (propionyl) -2-biphenylmethylamine; 0 0.048 g, [M ⁺⁺ H] = 538.83.

2′-chloro-5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -N- (propionyl) -2-biphenylmethylamine; 0 0.058 g, [M ⁺⁺ H] = 554.79.

3′-chloro-5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -N- (propionyl) -2-biphenylmethylamine; 0 0.064 g, [M ⁺⁺ H] = 554.80.

4'-chloro-5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -N- (propionyl) -2-biphenylmethylamine; 0 0.064 g, [M ⁺⁺ H] = 554.78.

5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -2'-methyl-N- (propionyl) -2-biphenylmethylamine; 0 0.03 g, [M ⁺⁺ H] = 534.86.

5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -3'-methyl-N- (propionyl) -2-biphenylmethylamine; 0 0.067 g, [M ⁺⁺ H] = 534.87.

5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -4'-methyl-N- (propionyl) -2-biphenylmethylamine; 0 .072g, [M ⁺⁺ H] = 534.87.

3′-cyano-5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -N- (propionyl) -2-biphenylmethylamine; 0 .068 g, [M ⁺⁺ H] = 545.82.

4'-cyano-5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -N- (propionyl) -2-biphenylmethylamine; 0 .062 g, [M ⁺⁺ H] = 545.83.

3′-amino-5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -N- (propionyl) -2-biphenylmethylamine; 0 .018 g, [M ⁺⁺ H] = 535.85.

3′-acetamido-5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -N- (propionyl) -2-biphenylmethylamine; 0 0.054 g, [M ⁺⁺ H] = 577.84.

5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -4'-dimethylamino-N- (propionyl) -2-biphenylmethylamine; 0.057 g, [M ⁺⁺ H] = 563.88.

4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -2- (1-naphthyl) -N- (propionyl) benzylamine; 074 g, [M ⁺⁺ H] = 570.85.

4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -2- (2-thienyl) -N- (propionyl) benzylamine; 044 g, [M ⁺⁺ H] = 526.81.

2- (6-Chloro-3-pyridyl) -4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -N- (propionyl) benzyl ^{amine; 0.063g, [M + + H} ] = 555.79.

Synthesis Example 11
3-chloro-N-cyclopropylcarbonyl-5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -2-pyridylmethylamine (invention) Compound No. 5-005).

Step 1; Preparation of 5- (3,5-dichlorophenyl) -3- (5,6-dichloro-3-pyridyl) -5-trifluoromethyl-4,5-dihydroisoxazole 5,6-Dichloronicotinaldehyde oxime To a solution of 2.1 g of 1,2-dimethoxyethane in 30 ml, 2.3 g of N-chlorosuccinimide was added and stirred at 70 ° C. for 4 hours. The reaction mixture was then allowed to cool to room temperature, 2.5 g of 3,5-dichloro-1- [1- (trifluoromethyl) ethenyl] benzene synthesized in Step 1 of Synthesis Example 1, 1.4 g of potassium bicarbonate and water. 2.0 ml was added and stirring was continued for another 20 hours at room temperature. After completion of the reaction, the reaction mixture was diluted with 70 ml of ethyl acetate and washed with water (50 ml × 1). The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Co., Ltd. medium pressure preparator; YFLC-Wprep) eluting with ethyl acetate-hexane (1:10 to 1: 5 gradient). 1.7 g was obtained as white crystals.
Melting point: 155.0-157.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ 8.48 (d, J = 1.8Hz, 1H), 8.16 (d, J = 1.8Hz, 1H), 7.49 (s, 2H), 7.45 (t, J = 1.5Hz, 1H), 4.07 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H).

Step 2; Preparation of 3- (5-chloro-6-cyano-3-pyridyl) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 5- (3,5 -Dichlorophenyl) -3- (5,6-dichloro-3-pyridyl) -5-trifluoromethyl-4,5-dihydroisoxazole in a solution of 1.40 g of N, N-dimethylacetamide in 30 ml of zinc cyanide 0.075 g Then, 0.37 g of tetrakis (triphenylphosphine) palladium (0) was added, and the mixture was stirred at 80 ° C. to 120 ° C. for 4.5 hours under a nitrogen atmosphere. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, 5 ml of aqueous ammonia and 50 ml of water were added, and the mixture was extracted with ethyl acetate (50 ml × 1). The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, and the residue was eluted with ethyl acetate-hexane (1: 8 to 1: 3 gradient). Purification by preparative liquid chromatography (Yamazen Corporation medium pressure fractionator; YFLC-Wprep) gave 1.20 g of the desired product as a yellow resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ8.83 (d, J = 1.8Hz, 1H), 8.19 (d, J = 1.8Hz, 1H), 7.48 (s, 2H), 7.45-7.5 ( m, 1H), 4.09 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H).

Step 3; 3- (6-Aminomethyl-5-chloro-3-pyridyl) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole (Compound No. 10 of the present invention) -001) 3- (5-Chloro-6-cyano-3-pyridyl) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 0.32 g of methanol 12 ml Concentrated hydrochloric acid (0.5 ml) and 5% palladium on charcoal (0.10 g) were added to the solution, and the mixture was stirred at room temperature for 2.5 hours in a hydrogen atmosphere under normal pressure. After completion of the reaction, the reaction mixture was filtered through Celite, and the solvent was distilled off under reduced pressure to obtain 0.30 g of the desired product as a brown resinous substance.
¹ H NMR (CDCl ₃ -DMSO-d ₆ , Me ₄ Si, 300 MHz) δ8.89 (s, 1H), 8.59 (bs, 2H), 8.32 (s, 1H), 7.83 (s, 1H), 7.60 ( s, 2H), 4.53 (d, J = 18.6Hz, 1H), 4.3-4.45 (m, 3H).

Step 4: 3-chloro-N-cyclopropylcarbonyl-5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -2-pyridylmethylamine Preparation of 3- (6-aminomethyl-5-chloro-3-pyridyl) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 0.10 g and triethylamine 0.03 g 0.02 g of cyclopropanecarbonyl chloride was added dropwise to 2.0 ml of a solution of chloroform under ice-cooling, and stirring was continued for another hour at room temperature. After completion of the reaction, the reaction mixture was washed with 5 ml of a saturated aqueous sodium hydrogen carbonate solution and then with 5 ml of water. The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Co., Ltd. medium pressure preparator; YFLC-Wprep) eluting with ethyl acetate-hexane (1: 5 to 1: 1 gradient). 0.071 g was obtained as yellow crystals.
Melting point 136.0-138.0 ° C.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ8.68 (d, J = 1.8Hz, 1H), 8.04 (d, J = 1.8Hz, 1H), 7.50 (s, 2H), 7.45 (t, J = 1.5Hz, 1H), 7.12 (bs, 1H), 4.71 (d, J = 4.8Hz, 2H), 4.08 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H) , 1.5-1.65 (m, 1H), 1.0-1.1 (m, 2H), 0.75-0.85 (m, 2H).

Synthesis Example 12
N-[[2-Chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] methyl] -1H-imidazole-1- Carboxamide (Compound No. 2-040 of the present invention).

3- (4-Aminomethyl-3-chlorophenyl) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisosynthesized in the same manner as in Step 1 to Step 6 of Synthesis Example 7. 0.40 g of 1,1′-carbonylbis-1H-imidazole was added to a solution of 1.0 g of oxazole (present compound No. 9-011) in 20 ml of tetrahydrofuran and stirred at room temperature for 3 hours. After completion of the reaction, the reaction mixture was diluted with 50 ml of ethyl acetate and washed with water (15 ml × 2). The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Co., Ltd. medium pressure preparator; YFLC-Wprep) eluting with ethyl acetate-hexane (1: 5 to 1: 1 gradient). 0.75 g was obtained as a yellow resinous material.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ8.10 (s, 1H), 7.73 (s, 1H), 7.54 (s, 2H), 7.45-7.5 (m, 2H), 7.43 (t, J = 1.5Hz, 1H), 7.31 (t, J = 1.5Hz, 1H), 7.08 (s, 1H), 6.43 (bs, 1H), 4.69 (d, J = 5.7Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.07 (d, J = 17.4Hz, 1H).

Synthesis Example 13
N-[[2-Chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] methyl] carbamic acid-2,2, 2-trifluoroethyl (the present compound No. 3-004).

0.033 g of 55% oily sodium hydride was added to 4.01 ml of N, N-dimethylformamide in 0.091 g of 2,2,2-trifluoroethanol under ice-cooling, and the mixture was stirred at the same temperature for 10 minutes. did. After the evolution of hydrogen gas ceases, N-[[2-chloro-4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] Methyl] -1H-imidazole-1-carboxamide (the present compound No. 2-040) (0.19 g) in N, N-dimethylformamide (1.0 ml) was added, and stirring was continued for an additional 2.5 hours at the same temperature. did. After completion of the reaction, the reaction mixture was diluted with 30 ml of ethyl acetate and washed with water (20 ml × 1). The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Co., Ltd. medium pressure preparator; YFLC-Wprep) eluting with ethyl acetate-hexane (1: 5 to 1: 2 gradient) 0.091 g was obtained as a yellow resinous material.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.69 (d, J = 1.8Hz, 1H), 7.54 (dd, J = 8.1, 1.8Hz, 1H), 7.49 (d, J = 1.5Hz, 2H), 7.44 (d, J = 8.1Hz, 1H), 7.42 (t, J = 1.5Hz, 1H), 5.43 (t, J = 6.3Hz, 1H), 4.4-4.45 (m, 4H), 4.06 ( d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H).

Synthesis Example 14
1-[[2-Chloro-4- [5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] methyl] -3-cyclo Propyl urea (the present compound No. 4-024).

N-[[2-chloro-4- [5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] synthesized in the same manner as in Synthesis Example 12. 11.4 mg of cyclopropylamine was added to 2.0 ml of tetrahydrofuran in 100.0 mg of [phenyl] methyl] -1H-imidazole-1-carboxamide (present compound No.2-302) and stirred at room temperature for 3 hours. . After completion of the reaction, 3 ml of ethyl acetate was added to the reaction mixture and washed with water. The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Corporation medium pressure preparative device; YFLC-Wprep) eluting with ethyl acetate-hexane (1: 9 to 1: 3 gradient). 69.0 mg was obtained as a yellow resinous material.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.6-7.65 (m, 3H), 7.4-7.5 (m, 2H), 5.66 (bs, 1H), 5.04 (bs, 1H), 4.50 (d , J = 6.0Hz, 2H), 4.05 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H), 2.4-2.5 (m, 1H), 0.7-0.8 (m, 2H) , 0.5-0.6 (m, 2H).

Synthesis Example 15
1-[[4- [5- (3,5-Dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] methyl] -3- (2,2,2-tri Fluoroethyl) urea (the present compound No. 4-001).

To a solution of 0.12 g of 1,1′-carbonylbis-1H-imidazole in 7.0 ml of tetrahydrofuran, 0.20 g of 2,2,2-trifluoroethylamine was added and stirred at room temperature for 1.5 hours. Subsequently, 3- [4- (aminomethyl) phenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisotope synthesized in Step 6 of Synthesis Example 1 was added to this reaction mixture. A solution of 0.39 g of oxazole (Compound No. 9-001 of the present invention) in 5.0 ml of tetrahydrofuran was added, and stirring was continued for another 2.5 hours at room temperature. After completion of the reaction, the reaction mixture was diluted with 20 ml of ethyl acetate, washed with water (15 ml × 2), washed with water, dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Co., Ltd. medium pressure preparative device; YFLC-Wprep) eluting with ethyl acetate-hexane (1: 8 to 1: 1 gradient). 0.43 g was obtained as a colorless resinous material.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.63 (d, J = 8.1 Hz, 2H), 7.51 (s, 2H), 7.43 (s, 1H), 7.34 (d, J = 8.1 Hz, 2H), 4.81 (bs, 1H), 4.63 (bs, 1H), 4.44 (d, J = 6.0Hz, 2H), 4.07 (d, J = 17.4Hz, 1H), 3.8-3.95 (m, 2H), 3.66 (d, J = 17.4Hz, 1H).

Synthesis Example 16
2-Chloro-N-cyclopropylcarbonyl-N-ethyl-4- [5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzylamine (Invention compound No. 7-022).

Step 1; 3- [4- (Ethylamino) methyl-3-chlorophenyl] -5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole (Compound No. of the present invention) .9-037) 3- [4-Bromomethyl-3-chlorophenyl] -5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4 synthesized in Step 4 of Synthesis Example 7 To a solution of 0.52 g of 5-dihydroisoxazole in 10 ml of isopropyl alcohol and 1 ml of water were added 0.27 g of 33% ethylamine aqueous solution and 0.01 g of potassium iodide, and the mixture was stirred at room temperature for 17 hours. After completion of the reaction, the solvent was distilled off under reduced pressure, the residue was dissolved in 10 ml of ethyl acetate and 5 ml of water, the organic layer was separated, and the aqueous layer was extracted with ethyl acetate (10 ml × 2). The organic layers were combined, saturated brine and then anhydrous sodium sulfate in this order, dried and dried, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (4: 1). Purification gave 0.24 g of the desired product as a colorless resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.64 (s, 1H), 7.63 (s, 2H), 7.52 (d, J = 9.0Hz, 1H), 7.51 (d, J = 9.0Hz, 1H), 4.06 (d, J = 17.1Hz, 1H), 3.91 (s, 2H), 3.63 (d, J = 17.1Hz, 1H), 2.68 (q, J = 7.2Hz, 2H), 1.14 (t, J = 7.2Hz, 3H).

Step 2: 2-chloro-N-cyclopropylcarbonyl-N-ethyl-4- [5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl Preparation of benzylamine 3- [4- (Ethylamino) methyl-3-chlorophenyl] -5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 0.19 g Then, 0.05 g of cyclopropanecarbonyl chloride was added dropwise to a solution of 0.06 g of triethylamine in 5.0 ml of dichloromethane under ice-cooling, and stirring was continued for another 10 minutes at room temperature. After completion of the reaction, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (3: 7) to obtain 0.16 g of the desired product as a colorless resinous substance. It was.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.74 and 7.63 (s, 1H), 7.63 (s, 2H), 7.45-7.55 (m, 1H), 7.25-7.35 (m, 1H), 4.76 and 4.71 (s, 2H), 4.07 and 4.04 (d, J = 17.1Hz, 1H), 3.67 and 3.64 (d, J = 17.1Hz, 1H), 3.4-3.55 (m, 2H), 1.75-1.9 and 1.35 -1.5 (m, 1H), 1.26 and 1.15 (t, J = 6.6Hz, 3H), 1.0-1.1 (m, 2H), 0.8-0.9 and 0.6-0.75 (m, 2H).

Synthesis Example 17
2-Chloro-N- (cyanomethyl) -N-cyclopropylcarbonyl-4- [5- (3,4,5-trichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] Benzylamine (the present compound No. 7-028).

  To a 20 ml dichloromethane solution of 0.77 g aminoacetonitrile sulfate, 1.52 g triethylamine and 0.52 g cyclopropanecarbonyl chloride were added and stirred at room temperature for 1 hour. After completion of the reaction, the solvent was distilled off under reduced pressure, the residue was dissolved in 20 ml of diethyl ether and 10 ml of water, the organic layer was separated, the aqueous layer was acidified with 2N aqueous hydrochloric acid solution, and then diluted with diethyl ether. And extracted (20 ml × 2). The organic layers were combined, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain crude N- (cyanomethyl) cyclopropanecarboxamide as white crystals.

To a suspension of 0.02 g of 55% oily sodium hydride in 5 ml of tetrahydrofuran was added dropwise a solution of 0.06 g of crude N- (cyanomethyl) cyclopropanecarboxamide in 5 ml of tetrahydrofuran under ice-cooling and stirring. And stirred for 30 minutes. After the generation of hydrogen gas ceased, 3- [4-bromomethyl-3-chlorophenyl] -5- (3,4,5-trichlorophenyl) -5-trifluoromethyl- synthesized in Step 4 of Synthesis Example 7 A solution of 0.25 g of 4,5-dihydroisoxazole in 5 ml of tetrahydrofuran was added, and stirring was continued for another 15 hours at room temperature. After completion of the reaction, the reaction mixture was poured into 20 ml of ice water and extracted with ethyl acetate (20 ml × 2). The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (2: 3) to obtain 0.15 g of the desired product as a colorless resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ 7.79 (s, 1H), 7.55-7.7 (m, 3H), 7.33 (d, J = 8.1Hz, 1H), 4.95 and 4.82 (s, 2H ), 4.35 (s, 2H), 4.09 (d, J = 17.4Hz, 1H), 3.71 (d, J = 17.4Hz, 1H), 1.55-1.85 (m, 1H), 0.8-1.15 (m, 4H) .

Synthesis Example 18
4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -N- (2,2,2-trifluoropropanethioyl) benzylamine (present Invention compound No. 5-008).

4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -N- (2,2,2-) synthesized in the same manner as in Synthesis Example 1. Trifluoropropionyl) benzylamine (the present compound No. 2-005) 0.25 g and Lawesson's reagent (2,4-bis (4-methoxyphenyl) -1,3,4,4-dithiadiphosphetane = 2 , 4-disulfide) A solution of 0.40 g of toluene in 10 ml of toluene was stirred for 3 hours under reflux. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, diluted with 20 ml of ethyl acetate, washed with water (10 ml × 1), dehydrated and dried in the order of saturated brine and anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Mortex medium pressure preparator; Purif-α2) eluting with ethyl acetate-hexane (1: 9 to 1: 1 gradient). 0.80 g was obtained as a yellow resinous material.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.87 (bs, 1H), 7.66 (d, J = 8.4 Hz, 2H), 7.48 (s, 2H), 7.42 (t, J = 1.5 Hz, 1H), 7.34 (d, J = 8.4Hz, 2H), 4.90 (d, J = 5.4Hz, 2H), 4.07 (d, J = 17.4Hz, 1H), 3.55-3.75 (m, 3H).

Synthesis Example 19
N-butyryl-2-chloro-4- [5- (3,5-dibromo-4-fluorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzylamine (the compound of the present invention) No.2-388).

  Step 1: Preparation of 1- (3,5-dibromo-4-fluorophenyl) -2,2,2-trifluoroethanone.

To a solution of 1.00 g of 1- (4-fluorophenyl) -2,2,2-trifluoroethanone in 0.2 ml of acetic acid and 1.0 ml of concentrated sulfuric acid was added 1,3-dibromo-5,5- 1.79 g of dimethylhydantoin was added and stirred at 45 ° C. for 3 hours. After completion of the reaction, the reaction mixture was poured into 5 ml of ice water, and 2N aqueous sodium hydroxide solution was added to adjust the pH to 7, followed by extraction with ethyl acetate (3 ml × 2). Dehydration, drying and evaporation of the solvent under reduced pressure gave 0.99 g of the desired product as a colorless oil.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ8.23 (dd, J = 6.0, 0.9 Hz, 2H).

Step 2: Preparation of 1- (3-chloro-4-methylphenyl) -3- (3,5-dibromo-4-fluorophenyl) -4,4,4-trifluoro-3-hydroxybutan-1-one To a solution of 0.99 g of 1- (3,5-dibromo-4-fluorophenyl) -2,2,2-trifluoroethanone and 0.48 g of 1- (3-chloro-4-methylphenyl) ethanone in 3 ml of ethyl acetate Diethylamine (0.062 g) was added, and the mixture was stirred at 50 ° C. for 2 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Mortex medium pressure preparator; Purif-α2) eluting with ethyl acetate-hexane (1:10), and 1.40 g of the target product was pale yellow. Obtained as an oil.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.90 (d, J = 1.5Hz, 1H), 7.75 (d, J = 6.0Hz, 2H), 7.72 (s, 1H), 7.39 (d, J = 7.8Hz, 1H), 5.76 (s, 1H), 3.80 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H), 2.47 (s, 3H).

Step 3; Preparation of 1- (3-chloro-4-methylphenyl) -3- (3,5-dibromo-4-fluorophenyl) -4,4,4-trifluoro-2-buten-1-one 1 -(3-Chloro-4-methylphenyl) -3- (3,5-dibromo-4-fluorophenyl) -4,4,4-trifluoro-3-hydroxybutan-1-one 1.40 g of toluene 3 ml While stirring at 80 ° C., 0.68 g of thionyl chloride and 0.46 g of pyridine were added to the solution, and stirring was continued at the same temperature for 2 hours. After completion of the reaction, 3 ml of water was added to the reaction mixture under ice cooling, and stirring was continued until the reaction mixture returned to room temperature. The organic layer was separated and added to 3 ml of 2N aqueous sodium hydroxide solution and stirred at room temperature for 30 minutes. The organic layer was separated, dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain 1.37 g of the crude desired product as a yellow oily substance. This product was directly used in the next step without further purification.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ 7.55-7.8 (m, 2H), 7.25-7.4 (m, 4H), 2.44 (s, 3H).

Step 4; Preparation of 3- (3-chloro-4-methylphenyl) -5- (3,5-dibromo-4-fluorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 1- (3 -Chloro-4-methylphenyl) -3- (3,5-dibromo-4-fluorophenyl) -4,4,4-trifluoro-2-buten-1-one and tetrabutylammonium bromide A solution of 0.33 g of sodium hydroxide in 0.8 ml of water and 1.3 ml of hydroxylamine sulfate in 1.3 ml of water was added dropwise to 27 g of toluene in 8 ml of the solution under ice-cooling. Stir. After completion of the reaction, 5 ml of 3N hydrochloric acid solution was added to the reaction mixture with stirring under ice cooling, and the organic layer was separated, washed with 5 ml of water and then 5 ml of saturated aqueous sodium bicarbonate solution, then with saturated brine and then anhydrous sodium sulfate. The solvent was distilled off under dehydration / drying and reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Mortex medium pressure preparator; Purif-α2) eluting with ethyl acetate-hexane (1:10), and 1.10 g of the target product was pale yellow. Obtained as a resinous material.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.75 (d, J = 5.7 Hz, 2H), 7.61 (d, J = 1.8 Hz, 1H), 7.4-7.5 (m, 1H), 7.25- 7.35 (m, 1H), 4.06 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 2.41 (s, 3H).

Step 5; N-[[2-Chloro-4- [5- [3,5-dibromo-4-fluorophenyl] -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] methyl Preparation of phthalimide 3- (3-Chloro-4-methylphenyl) -5- (3,5-dibromo-4-fluorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 1.10 g of 1 Then, 0.38 g of N-bromosuccinimide and 0.028 g of α, α′-azobisisobutyronitrile were added to a solution of 7 ml of 2-dichloroethane, and the mixture was stirred for 3 hours while heating under reflux. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, 10 ml of 1,2-dichloroethane was added, washed with water (30 ml × 1), dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was dissolved in 7 ml of N, N-dimethylformamide, 0.40 g of potassium phthalimide was added, and the mixture was stirred at room temperature for 15 hours. After completion of the reaction, the reaction mixture was poured into 10 ml of water and extracted with ethyl acetate (10 ml × 2). The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. 0.75 g of product was obtained as a pale yellow resinous material. This product was directly used in the next step without further purification.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300MHz) δ7.90 (dd, J = 5.7, 3.0Hz, 2H), 7.77 (dd, J = 5.7, 3.0Hz, 2H), 7.74 (d, J = 6.0 Hz, 2H), 7.67 (d, J = 1.8Hz, 1H), 7.45-7.55 (m, 1H), 7.25-7.35 (m, 1H), 5.00 (s, 2H), 4.03 (d, J = 17.4Hz , 1H), 3.64 (d, J = 17.4 Hz, 1H).

Step 6; Preparation of 3- (4-aminomethyl-3-chlorophenyl) -5- (3,5-dibromo-4-fluorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole N-[[ 2-chloro-4- [5- [3,5-dibromo-4-fluorophenyl] -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] methyl] phthalimide 0.75 g ethanol To the 10 ml solution was added 1.07 g of an aqueous hydrazine monohydrate solution, and the mixture was stirred for 1 hour while heating under reflux. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, the insoluble material was filtered off, and the solvent was distilled off under reduced pressure. The residue was dissolved by adding 10 ml of chloroform, the insoluble matter was again filtered off, the filtrate was washed with water (10 ml × 1), dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography eluting with methanol-ethyl acetate (1: 9) to obtain 0.51 g of the desired product as a yellow resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.76 (d, J = 5.7 Hz, 2H), 7.65 (d, J = 1.5 Hz, 1H), 7.45-7.6 (m, 2H), 4.07 ( d, J = 17.4Hz, 1H), 3.96 (s, 2H), 3.68 (d, J = 17.4Hz, 1H), 1.67 (bs, 2H).

Step 7; of N-butyryl-2-chloro-4- [5- (3,5-dibromo-4-fluorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzylamine Preparation 3- (4-aminomethyl-3-chlorophenyl) -5- (3,5-dibromo-4-fluorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 70 mg and triethylamine 15 mg in 2 ml dichloromethane Then, 15.4 mg of butyric chloride was added dropwise under ice cooling and stirring was continued for another hour at room temperature. After completion of the reaction, the reaction mixture was diluted with 2 ml of chloroform, 3 ml of saturated aqueous sodium hydrogen carbonate solution was added, the organic layer was separated, dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. did. The residue was purified by medium pressure preparative liquid chromatography eluting with ethyl acetate-hexane (1:10) (Mortex medium pressure preparator; Purif-α2), and 42 mg of the target product was a colorless resinous substance. Got as.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.75 (d, J = 5.4 Hz, 2H), 7.67 (d, J = 1.2 Hz, 1H), 7.4-7.55 (m, 2H), 5.98 ( bs, 1H), 4.53 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 2.20 (t, J = 7.5Hz, 2H), 1.67 (sxt, J = 7.5Hz, 2H), 0.94 (t, J = 7.5Hz, 3H).

Reference example 1
4-Chloro-3-trifluoromethyl-1- [1- (trifluoromethyl) ethenyl] benzene.

In a nitrogen atmosphere, 53 g of a 1M tetrahydrofuran solution of 1- (trifluoromethyl) ethenylzinc bromide prepared according to the method described in the literature was added to 7.1 g of 2-chloro-5-iodobenzotrifluoride and dichlorobis (triphenylphosphine). 0.65 g of palladium (II) was added, and the mixture was stirred for 2.5 hours while heating under reflux. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, 200 ml of hexane was added, and the precipitated insoluble material was filtered off. The filtrate was washed with water (50 ml x 1), dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography eluting with hexane. 4.8 g was obtained as a colorless oil.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.75 (s, 1H), 7.57 (d, J = 8.8Hz, 1H), 7.54 (d, J = 8.8Hz, 1H), 6.08 (s, 1H), 5.84 (s, 1H).

Reference example 2
3,5-bis (trifluoromethyl) -1- [1- (trifluoromethyl) ethenyl] benzene.

To a solution of 2,0 g of 3,5-bis (trifluoromethyl) phenylboronic acid in 100 ml of tetrahydrofuran and 40 ml of water, 20.2 g of 2-bromo-3,3,3-trifluoropropene, 30.0 g of potassium carbonate and 1, 0.023 g of 3-bis (2,6-diisopropylphenyl) imidazol-2-ylidene (1,4-naphthoquinone) palladium (0) dimer was added, and the mixture was stirred at 60 ° C. for 3 hours in a nitrogen atmosphere. After completion of the reaction, it was allowed to cool to room temperature, 100 ml of ice water was added and extracted with ethyl acetate (100 ml × 2), the organic layer was washed with water, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. did. The residue was purified by silica gel column chromatography eluting with hexane to obtain 21.9 g of the desired product as an orange oily substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.92 (s, 1H), 7.89 (s, 2H), 6.18 (s, 1H), 5.93 (d, J = 1.5 Hz, 1H).

Reference example 3
3,4-Dichloro-5-methyl-1- [1- (trifluoromethyl) ethenyl] benzene.

In a nitrogen atmosphere, 19 ml of a 1M tetrahydrofuran solution of 1- (trifluoromethyl) ethenylzinc bromide prepared according to the method described in the literature was added to 2.2 g of 5-bromo-2,3-dichlorotoluene in N, N-dimethylformamide. 10 ml solution was added and tetrahydrofuran was distilled off under reduced pressure. To the remaining N, N-dimethylformamide solution, 0.26 g of dichlorobis (triphenylphosphine) palladium (II) was added and stirred at 100 ° C. for 3.5 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, 200 ml of a tetrahydrofuran-hexane (2: 5) mixture was added, and the precipitated insoluble material was filtered off. The filtrate was washed with water (100 ml x 1), dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography eluting with hexane. 2.3 g was obtained as a brown oil.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ 7.40 (s, 1H), 7.22 (s, 1H), 5.99 (s, 1H), 5.77 (s, 1H), 2.44 (s, 3H).

Reference example 4
3,4-Dichloro-5-trifluoromethyl-1- [1- (trifluoromethyl) ethenyl] benzene.

Under a nitrogen atmosphere, a solution of 26.2 g of 5-bromo-2,3-dichlorobenzotrifluoride and 9.1 g of diisopropyl ether in 250 ml of hexane was stirred at -10 ° C. under a n-butyllithium hexane solution (1.55 M). 57.5 ml was slowly added dropwise. After completion of the dropwise addition, the mixture was stirred at the same temperature for 30 minutes, then, a solution of 9.26 g of trimethoxyborane in 30 ml of tetrahydrofuran was dropped, and stirring was continued at room temperature for another 10 minutes. To this reaction mixture was added 150 ml of water, 23.4 g of 2-bromo-3,3,3-trifluoropropene, 36.9 g of potassium carbonate and 1,3-bis (2,6-diisopropylphenyl) imidazol-2-ylidene (1 , 4-Naphthoquinone) palladium (0) dimer (0.131 g) was added, and the mixture was stirred at 60 ° C. for 4 hours. After completion of the reaction, the mixture was allowed to cool to room temperature, 50 ml of ice water and 75 ml of ethyl acetate were added, and the insoluble material was filtered off and washed with 75 ml of ethyl acetate. The organic layer of the filtrate was separated, washed with water, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography eluting with hexane to obtain 21.8 g of the desired product as a colorless oil.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ 7.73 (s, 1H), 7.68 (s, 1H), 6.12 (s, 1H), 5.87 (s, 1H).

Reference Example 5
3,5-Dichloro-4-difluoromethoxy-1- [1- (trifluoromethyl) ethenyl] benzene.

Step 1; Preparation of 4-bromo-2,6-dichloro-1- (difluoromethoxy) benzene 1.4 g of potassium carbonate and ethyl bromodifluoroacetate in a 25 ml acetonitrile solution of 2.3 g of 4-bromo-2,6-dichlorophenol 3.8 g was added and stirred for 4 hours under reflux. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, poured into 100 ml of water and extracted with ethyl acetate (100 ml × 1). The organic layer was washed with water, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 4) to obtain 2.4 g of the objective product as a yellow oil.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ 7.54 (s, 2H), 6.56 (t, J = 73.6 Hz, 1H).

Step 2; Preparation of 3,5-dichloro-4-difluoromethoxy-1- [1- (trifluoromethyl) ethenyl] benzene Preparation of 1- (trifluoromethyl) ethenylzinc bromide prepared according to the literature method To 21 ml of 1M tetrahydrofuran solution, 2.4 ml of N, N-dimethylformamide in 2.4 g of 4-bromo-2,6-dichloro-1- (difluoromethoxy) benzene was added, and tetrahydrofuran was distilled off under reduced pressure. To the remaining N, N-dimethylformamide solution was added 0.23 g of dichlorobis (triphenylphosphine) palladium (II), and the mixture was stirred at 100 ° C. for 3 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, poured into 100 ml of water and extracted with diethyl ether (100 ml × 1). The organic layer was washed with water, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography eluting with hexane to obtain 1.8 g of the desired product as a brown oily substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ 7.47 (s, 2H), 6.61 (t, J = 73.6 Hz, 1H), 6.08 (s, 1H), 5.83 (s, 1H).

Reference Example 6
1- [3-Bromo-5- (trifluoromethyl) phenyl] -2,2,2-trifluoroethanone 2,2,2-trifluoro-1- [3- (trifluoromethyl) phenyl] ethanone 5. 3.54 g of 1,3-dibromo-5,5-dimethylhydantoin was added to 1 ml of 00 g of acetic acid and 6 ml of concentrated sulfuric acid, and the mixture was stirred at 35 ° C. for 3.5 hours. After completion of the reaction, the reaction mixture was poured into 60 ml of ice water and extracted with chloroform (30 ml × 2). The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution (50 ml × 1), dehydrated and dried in the order of saturated brine, then anhydrous magnesium sulfate, and reduced pressure. The solvent was distilled off under. The residue was dissolved in 20 ml of hexane, insoluble matter was filtered off, and the solvent was distilled off under reduced pressure to obtain 6.50 g of the desired product as a yellow oily substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ 8.36 (s, 1H), 8.23 (s, 1H), 8.11 (s, 1H).

Reference Example 7
1- (3,5-Dibromo-4-chlorophenyl) -2,2,2-trifluoroethanone.

To a solution of 2.00 g of 1- (4-chlorophenyl) -2,2,2-trifluoroethanone in 0.5 ml of acetic acid and 2.8 ml of concentrated sulfuric acid was added 1,3-dibromo-5,5-dimethyl under ice-cooling and stirring. 3.02 g of hydantoin was added and stirred at 35 ° C. After 3 hours, 0.7 ml of acetic acid, 2.0 ml of concentrated sulfuric acid and 0.35 g of 1,3-dibromo-5,5-dimethylhydantoin were added, and stirring was continued at the same temperature for another 3 hours. After completion of the reaction, the reaction mixture was poured into 50 ml of ice water, extracted with chloroform (50 ml × 1), the organic layer was washed with 50 ml of saturated aqueous sodium hydrogen carbonate solution, dehydrated and dried in the order of saturated brine and then anhydrous magnesium sulfate, under reduced pressure. The solvent was distilled off. The residue was dissolved in 20 ml of hexane, insoluble matter was filtered off, and the solvent was distilled off under reduced pressure to obtain 3.89 g of the desired product as a yellow oily substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ8.24 (s, 2H).

Reference Example 8
2,2,2-trifluoro-1- [3-iodo-5- (trifluoromethyl) phenyl] ethanone.

To 2.42 g of 2,2,2-trifluoro-1- [3- (trifluoromethyl) phenyl] ethanone were added 6 ml of 30% fuming sulfuric acid and 1.90 g of iodine, and the mixture was stirred at 50 ° C. for 5 hours. After completion of the reaction, the reaction mixture was poured into 10 g of ice and extracted with diethyl ether (20 ml × 1). The organic layer was washed with 10 ml of saturated sodium sulfite aqueous solution, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and reduced pressure. The solvent was distilled off to obtain 2.56 g of the desired product as a pale yellow oily substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ 8.53 (s, 1H), 8.28 (s, 1H), 8.25 (s, 1H).

  This invention compound can be manufactured according to the said manufacturing method and an Example. Although the example of this invention compound manufactured similarly to the synthesis example 1-the synthesis example 19 and those manufacture intermediates is shown in Table 5-Table 15, respectively, this invention is not limited only to these.

In the table, “Et” represents an ethyl group. Similarly, n-Pr or Pr-n represents a normal propyl group, i-Pr or Pr-i represents an isopropyl group, and c-Pr or Pr-c represents A cyclopropyl group, n-Bu or Bu-n is a normal butyl group, i-Bu or Bu-i is an isobutyl group, s-Bu or Bu-s is a secondary butyl group, c-Bu or Bu-c Represents a cyclobutyl group, t-Bu or Bu-t represents a tertiary butyl group, c-Pen or Pen-c represents a cyclopentyl group, c-Hex or Hex-c represents a cyclohexyl group, and Ph represents a phenyl group. ,
In addition, the aromatic heterocycles represented by D-1d to D-58a in the table each represent the following structure,

  The saturated heterocyclic rings represented by E-5a to E-27c in the table each represent the following structure,

  The partially saturated heterocyclic rings represented by M-7a to M-14a in the table each represent the following structure,

  In the table, T-1 to T-41 each represent the following structure.

Further, in the table, the number representing the substitution position of the substituent (X) _m corresponds to the position of the number described in the following structural formula,
In the table, Mw represents the calculated molecular weight, M ⁺⁺ H represents the measured molecular ion peak measured in the positive mode, * 1 is `` resinous '', * 2 is `` oily ''"Means each.
Table 5

―――――――――――――――――――――――――――――――――――――――
No. YR ⁴ R ² R ¹ Mw M ⁺ + H
―――――――――――――――――――――――――――――――――――――――
1-001 HHHC (O) Pr-i 459.29 459.11
1-002 HHHC (O) Pr-c 457.27 457.10
1-003 HHHC (O) CH ₂ Pr-c 471.30 470.95
1-004 HHHC (O) CH ₂ Cl 465.68 463.01 ^*
1-005 HHHC (O) CHF ₂ 467.22 466.90
1-006 HHHC (O) CH ₂ OCH ₃ 461.26 461.10
1-007 HHHC (O) CH ₂ OEt 475.29 474.95
1-008 HHHC (O) CH = C (CH ₃ ) ₂ 471.30 470.95
1-009 HHHC (O) OEt 461.26 461.12
1-010 HHHC (O) OPh 509.31 509.09
1-011 HHHC (O) NH (Ph-2-F) 526.31 525.87
1-012 HHHC (O) NH (Ph-4-F) 526.31 523.84 ^*
1-013 HHHC (O) NH (Ph-2-Cl) 542.77 541.72
1-014 HHHC (O) NH (Ph-3-Cl) 542.77 541.89
1-015 HHHC (O) NH (Ph-4-Cl) 542.77 541.87
1-016 HHHC (O) NH (Ph-2-Bu-t) 564.43 563.94
1-017 HHHC (O) NH (Ph-2-OCH ₃ ) 538.35 537.89
1-018 HHHC (O) NH (Ph-4-CN) 533.33 532.84
1-019 HHHC (O) NH [(D-54d) -2,6-Cl ₂ ] 578.20 576.78
1-020 HHHC (O) (Ph-2-Cl) 527.75 527.06
1-021 HHHC (O) (Ph-3-Cl) 527.75 524.98 ^*
1-022 HHHC (O) (Ph-4-Cl) 527.75 524.98 ^*
1-023 HHHC (O) (Ph-2-CH ₃ ) 507.33 506.80
1-024 HHHC (O) (Ph-2-CF ₃ ) 561.30 560.73
1-025 HHHC (O) NH (Ph-2-OEt) 552.37 550.57 ^*
1-026 HHHC (O) (Ph-2-NO ₂ ) 538.30 537.75
1-027 HHHC (O) (Ph-2-CN) 518.32 517.76
1-028 HHHC (O) (D-3a) 499.33 498.73
1-029 HHHC (O) (D-4a) 499.33 498.73
1-030 HHHC (O) (D-16e) 599.74 598.67
1-031 HHHC (O) (D-17b) Cl 531.74 530.71
1-032 HHHC (O) (D-53b) Cl 528.74 527.72
1-033 HHHC (O) (D-54b) Cl 528.74 527.73
1-034 HH CH ₃ C (O) Et 459.29 458.83
1-035 HH CH ₃ C (O) Pr-n 473.32 472.85
1-036 HH CH ₃ C (O) Pr-i 473.32 472.83
1-037 HH CH ₃ C (O) Pr-c 471.30 470.82
1-038 HH CH ₃ C (O) CH ₂ CH ₂ Cl 493.73 492.76
1-039 HH CH ₃ C (O) OCH ₃ 461.26 460.81
1-040 HH CH ₃ C (O) OEt 475.29 474.82
1-041 HH CH ₃ C (O) NHEt 474.30 473.84
1-042 HH Et C (O) Et 473.32 472.74
1-043 HH Et C (O) Pr-c 485.33 484.74
1-044 HH Et C (O) CF ₃ 513.26 512.68
1-045 HH Et C (O) CF ₂ CF ₃ 563.27 562.65
1-046 HH Et C (O) OCH ₃ 475.29 474.72
1-047 HH Et C (O) OEt 489.32 488.67
1-048 HH i-Pr C (O) CH ₃ 473.32 472.81
1-049 HH i-Pr C (O) Et 487.34 486.81
1-050 HH i-Pr C (O) OCH ₃ 489.32 488.79
1-051 HH i-Pr C (O) OEt 503.34 502.80
1-052 HH i-Pr C (O) NHEt 502.36 501.81
1-053 H CH ₃ HC (O) Pr-n 473.32 472.87
1-054 H CH ₃ HC (O) CH ₂ Bu-t 501.37 500.88
1-055 H CH ₃ -C (O) CH ₂ CH (CH ₃ ) C (O)-499.31 498.90
1-056 H CH ₃ -C (O) CH (CH ₃ ) C (CH ₃ ) ₂ C (O)-527.36 526.86
1-057 H CH ₃ -C (O) CH ₂ SC (O)-503.32 500.73
1-058 H CH ₃ -C (O) CH ₂ CH ₂ CH ₂ C (O)-499.31 498.87
1-059 H CH ₃ -C (O) CH ₂ OCH ₂ C (O)-527.36 500.86
1-060 H Et HC (O) Et 473.32 472.80
1-061 H Et HC (O) NHEt 488.33 487.81
1-062 Cl HHC (O) Et 479.71 478.84
1-063 Cl HHC (O) Pr-n 493.73 492.72
1-064 Cl HHC (O) Bu-i 507.76 506.73
1-065 Cl HHC (O) Bu-s 507.76 506.73
1-066 Cl HHC (O) Bu-c 505.75 504.67
1-067 Cl HHC (O) Pen-c 519.77 518.72
1-068 Cl HHC (O) CF ₃ 519.65 518.65
1-069 Cl HHC (O) CH ₂ CH ₂ Cl 514.15 512.59
1-070 Cl HHC (O) CH ₂ CH ₂ Br 558.60 556.53
1-071 Cl HHC (O) CHClCH ₃ 514.15 512.61
1-072 Cl HHC (O) CF ₂ CHF ₂ 551.67 550.53
1-073 Cl HHC (O) CF ₂ CF ₃ 569.66 568.63
1-074 Cl HHC (O) CF ₂ CF ₂ CF ₃ 619.67 618.46
1-075 Cl HHC (O) CH ₂ CH ₂ SCH ₃ 525.80 524.67
1-076 Cl HHC (O) CH ₂ C (O) OCH ₃ 523.72 522.64
1-077 Cl HHC (O) CH ₂ CH ₂ C (O) OCH ₃ 537.74 536.64
1-078 Cl HHC (O) CH = C (CH ₃ ) ₂ 505.75 506.66
1-079 Cl HHC (O) CH = CHEt 505.75 504.56
1-080 Cl HHC (O) CH ₂ CH = CHCH ₃ 505.75 506.66
1-081 Cl HHC (O) CH ₂ CH ₂ CH = CH ₂ 505.75 504.67
1-082 Cl HHC (O) (Ph-2-F) 545.74 544.62
1-083 Cl HHC (O) (Ph-2-Cl) 562.20 560.58
1-084 Cl HHC (O) (Ph-2-Br) 606.65 604.51
1-085 Cl HHC (O) (Ph-2-I) 653.65 652.45
1-086 Cl HHC (O) (Ph-2,4-F ₂ ) 563.73 562.62
1-087 Cl HHC (O) (D-52a) 528.74 527.63
1-088 Cl HHC (O) OCH ₃ 481.68 480.63
1-089 Cl HHC (O) OEt 495.71 494.70
1-090 Cl HHC (O) OPr-i 509.73 508.69
1-091 Cl HHC (O) NHEt 494.72 493.89
1-092 Cl HHC (O) N (Et) ₂ 522.78 521.68
1-093 Cl HHC (O) NHPr-i 508.75 507.68
1-094 Cl HHC (S) NHPr-c 522.80 521.63
1-095 IHHC (O) Pr-n 585.19 584.56
1-096 IHHC (O) Pr-c 583.17 582.55
1-097 IHHC (O) CF ₃ 611.10 608.40
1-098 IHHC (O) CF ₂ CF ₃ 661.11 658.36
1-099 IHHC (O) C (CH ₃ ) = CHCH ₃ 597.20 596.55
1-100 IHHC (O) (Ph-2-Cl) 653.65 652.47
1-101 IHHC (O) (D-53b) Cl 654.64 655.43
1-102 IHHC (O) OEt 587.16 586.55
1-103 IHHC (O) NHEt 586.17 585.55
1-104 CH ₃ HHC (O) Pr-i 473.32 472.93
1-105 Ph-4-FHHC (O) Et 539.35 538.83
1-106 Ph-2-Cl HHC (O) Et 555.80 554.79
1-107 Ph-3-Cl HHC (O) Et 555.80 554.80
1-108 Ph-4-Cl HHC (O) Et 555.80 554.78
1-109 Ph-2-CH ₃ HHC (O) Et 535.39 534.86
1-110 Ph-3-CH ₃ HHC (O) Et 535.39 534.87
1-111 Ph-4-CH ₃ HHC (O) Et 535.39 534.87
1-112 Ph-3-CN HHC (O) Et 546.37 545.82
1-113 Ph-4-CN HHC (O) Et 546.37 545.83
1-114 Ph-3-NH ₂ HHC (O) Et 536.37 535.85
1-115 Ph-3-NHC (O) CH ₃ HHC (O) Et 578.41 577.84
1-116 Ph-4-N (CH ₃ ) ₂ HHC (O) Et 564.43 563.88
1-117 1-Naph HHC (O) Et 571.42 570.85
1-118 D-3a HHC (O) Et 527.39 526.81
1-119 (D-53e) Cl HHC (O) Et 556.79 555.79
―――――――――――――――――――――――――――――――――――――――
In the above table, ^* represents an actual measurement value of the molecular ion peak of M ⁺ -H measured in the negative mode.
Table 6

―――――――――――――――――――――――――――――――――――――――
No. (X) _m YR ⁴ R ^1a mp (℃)
―――――――――――――――――――――――――――――――――――――――
2-001 3,5-Cl ₂ HH CH ₃ 171.0-173.0
2-002 3,5-Cl ₂ HH Et 143.0-145.0
2-003 3,5-Cl ₂ HH CH ₂ Pen-c 133.0-135.0
2-004 3,5-Cl ₂ HH CH ₂ Hex-c 112.0-114.0
2-005 3,5-Cl ₂ HH CH ₂ CF ₃ * 1
2-006 3,5-Cl ₂ HH CH ₂ CH ₂ OCH ₃ 134.0-136.0
2-007 3,5-Cl ₂ HH E-6a 149.0-151.0
2-008 3,5-Cl ₂ HH CH ₂ (T-20) 130.0-132.0
2-009 3,5-Cl ₂ HH CH ₂ CH ₂ C≡CH 126.0-127.0
2-010 3,5-Cl ₂ HH CH ₂ (D-52a) * 1
2-011 3,5-Cl ₂ HH CH ₂ (D-53a) 169.0-171.0
2-012 3,5-Cl ₂ HH CH ₂ (D-54a) 65.0-72.0
2-013 3,5-Cl ₂ HHC (O) CH ₃ 168.0-170.0
2-014 3,5-Cl ₂ HH (D-4c) OCH ₃ * 1
2-015 3,5-Cl ₂ HH D-52a 78.0-82.5
2-016 3,5-Cl ₂ H CH ₃ Et 121.0-124.0
2-017 3,5-Cl ₂ H CH ₃ i-Pr 89.0-91.0
2-017 (a) 99% de [α] _D ^23.9 + 158.72 ° (EtOH, c = 0.346) 176.0-179.0
2-017 (b) 99% de [α] _D ^24.0 + 28.77 ° (EtOH, c = 0.285) 170.0-172.0
2-017 (c) 99% de [α] _D ^24.0 -157.33 ° (EtOH, c = 0.334) 174.0-177.0
2-017 (d) 99% de [α] _D ^24.0 -29.02 ° (EtOH, c = 0.317) 170.0-172.0
2-018 3,5-Cl ₂ H CH ₃ c-Pr 139.0-141.0
2-019 3,5-Cl ₂ H CH ₃ n-Bu 109.0-111.0
2-020 3,5-Cl ₂ H CH ₃ t-Bu 125.0-128.0
2-021 3,5-Cl ₂ H CH ₃ CH ₂ CF ₃ * 1
2-022 3,5-Cl ₂ H CH ₃ CH ₂ CH ₂ CH ₂ Cl 95.0-98.0
2-023 3,5-Cl ₂ H CH ₃ C (CH ₃ ) ₂ CH ₂ Cl 113.0-116.0
2-024 3,5-Cl ₂ H Et i-Pr 135.0-138.0
2-025 3,5-Cl ₂ H Et CH ₂ CF ₃ * 1
2-026 3,5-Cl ₂ H CF ₃ i-Pr * 1
2-027 3,5-Cl ₂ H CN c-Pr 202.0-204.0
2-028 3,5-Cl ₂ H CN CH ₂ CF ₃ 164.0-166.0
2-029 3,5-Cl ₂ FH CH ₂ CF ₃ * 1
2-030 3,5-Cl ₂ Cl H i-Pr 155.0-157.0
2-031 3,5-Cl ₂ Cl H c-Pr 155.0-157.0
2-032 3,5-Cl ₂ Cl H CH ₂ CF ₃ 135.0-139.0
2-033 3,5-Cl ₂ Cl H E-5a * 1
2-034 3,5-Cl ₂ Cl H E-6a 149.0-152.0
2-035 3,5-Cl ₂ Cl H CH ₂ CN * 1
2-036 3,5-Cl ₂ Cl H Ph-3-F * 1
2-037 3,5-Cl ₂ Cl H Ph-4-F * 1
2-038 3,5-Cl ₂ Cl H Ph-3,5-F ₂ * 1
2-039 3,5-Cl ₂ Cl H Ph-2,6-Cl ₂ 259.0-262.0
2-040 3,5-Cl ₂ Cl H D-24a * 1
2-041 3,5-Cl ₂ Cl CH ₃ c-Pr * 1
2-042 3,5-Cl ₂ Cl CN c-Pr * 1
2-043 3,5-Cl ₂ Br H i-Pr 167.0-170.0
2-044 3,5-Cl ₂ Br H c-Pr 158.0-162.0
2-045 3,5-Cl ₂ Br H CH ₂ CF ₃ * 1
2-046 3,5-Cl ₂ IH Et * 1
2-047 3,5-Cl ₂ IH i-Pr 173.0-175.0
2-048 3,5-Cl ₂ IH i-Bu 79.0-82.0
2-049 3,5-Cl ₂ IH c-Bu 84.0-86.0
2-050 3,5-Cl ₂ IH CH ₂ CH ₂ Cl 155.0-158.0
2-051 3,5-Cl ₂ IH CH ₂ CF ₃ 150.0-152.0
2-052 3,5-Cl ₂ IH CH ₂ CH ₂ SCH ₃ 74.0-77.0
2-053 3,5-Cl ₂ CH ₃ H Et 159.0-161.0
2-054 3,5-Cl ₂ CH ₃ H CH ₂ CF ₃ 171.0-173.0
2-055 3,5-Cl ₂ CH ₃ H CH ₂ (D-52a) * 1
2-056 3,5-Cl ₂ NH ₂ H CH ₂ CF ₃ * 1
2-057 3,5-Cl ₂ NO ₂ H CH ₂ CF ₃ * 1
2-058 3,5-Cl ₂ Ph-2-FH Et * 1
2-059 3,4,5-Cl ₃ Cl H c-Pr * 1
2-060 3,5-Cl ₂ H Ph c-Pr * 1
2-061 3,5-Cl ₂ Cl H CH ₂ Pr-c * 1
2-062 3,5-Cl ₂ Cl H CH ₂ CH (CH ₃ ) CF ₃ * 1
2-063 3,5-Cl ₂ Cl H CH ₂ CH (CF ₃ ) ₂ * 1
2-064 3,5-Cl ₂ Cl H T-4 * 1
2-065 3,5-Cl ₂ Cl H T-11 * 1
2-066 3,5-Cl ₂ Cl H CH ₂ OCH ₃ * 1
2-067 3,5-Cl ₂ Cl H CH ₂ O (Ph-4-F) * 1
2-068 3,5-Cl ₂ Cl H CH ₂ CH ₂ OCH ₃ * 1
2-069 3,5-Cl ₂ Cl H CH ₂ SCH ₃ 144.0-146.0
2-070 3,5-Cl ₂ Cl H CH ₂ SO ₂ CH ₃ * 1
2-071 3,5-Cl ₂ Cl H CH ₂ NHC (O) Ph * 1
2-072 3,5-Cl ₂ Cl H T-13 * 1
2-073 3,5-Cl ₂ Cl H CH ₂ CH ₂ C≡CH * 1
2-074 3,5-Cl ₂ Cl H CH ₂ (Ph-4-F) 91.0-92.0
2-075 3,5-Cl ₂ Cl H T-16 * 1
2-076 3,5-Cl ₂ Cl H Ph-4-Cl * 1
2-077 3,5-Cl ₂ Cl H Ph-4-CF ₃ * 1
2-078 3,5-Cl ₂ Cl H Ph-2,4-Cl ₂ 206.0-208.0
2-079 3,5-Br ₂ Cl H c-Pr 137.0-140.0
2-080 3-Cl-5-CF ₃ Cl H c-Pr 127.0-130.0
2-081 3,5- (CF ₃ ) ₂ Cl H c-Pr 158.0-160.0
2-082 3,5-Cl ₂ -4-F Cl H c-Pr 133.0-135.0
2-083 3,5-Cl ₂ H CN i-Pr * 1
2-084 3,5-Cl ₂ HC (O) NH ₂ i-Pr 114.0-117.0
2-085 3,5-Cl ₂ HC (S) NH ₂ i-Pr 118.0-121.0
2-086 3,5-Cl ₂ H D-21a c-Pr * 1
2-087 3,5-Cl ₂ Cl H T-1 * 1
2-088 3,5-Cl ₂ Cl H CF (CH ₃ ) ₂ 143.0-145.0
2-089 3,5-Cl ₂ Cl H CH ₂ NH ₂ 69.0-72.0
2-090 3,5-Cl ₂ Cl H CH ₂ NHC (O) Pr-c 92.0-95.0
2-091 3,5-Cl ₂ Cl H CH ₂ NHC (O) OBu-t * 1
2-092 3,5-Cl ₂ Cl H CH = NOCH ₃ * 1
2-093 3,5-Cl ₂ Cl H Ph-4-CN * 1
2-094 3,5-Cl ₂ Cl H Ph-2-C (O) NHPr-c 228.0-231.0
2-095 3,5-Cl ₂ Br H CH ₂ Pr-c 70.0-74.0
2-096 3,5-Cl ₂ Br H E-5a 53.0-59.0
2-097 3,5-Cl ₂ Br H E-6a 174.0-178.0
2-098 3,5-Cl ₂ Br H Ph-2,4-F ₂ * 1
2-099 3,5-Cl ₂ CH ₃ H c-Pr 140.0-143.0
2-100 3,5-Cl ₂ NO ₂ H c-Pr * 1
2-101 3,5-Cl ₂ NHC (O) CH ₃ H CH ₂ CF ₃ 112.0-115.0
2-102 3,5-Cl ₂ N = C (CH ₃ ) OCH ₃ H CH ₂ CF ₃ * 1
2-103 3,4,5-Cl ₃ Cl HH * 1
2-104 3,5- (CF ₃ ) ₂ Cl H Et * 1
2-105 3,4,5-Cl ₃ Cl H Et * 1
2-106 3,5-Cl ₂ Br H Et * 1
2-107 3,4,5-Cl ₃ Br H Et * 1
2-108 3,4,5-Cl ₃ NO ₂ H Et * 1
2-109 3,4,5-Cl ₃ H CH ₃ Et * 1
2-110 3,5- (CF ₃ ) ₂ Cl H n-Pr 150.0-152.0
2-111 3,4,5-Cl ₃ Cl H n-Pr * 1
2-112 3,4,5-Cl ₃ Br H n-Pr * 1
2-113 3,4,5-Cl ₃ NO ₂ H n-Pr * 1
2-114 3,4,5-Cl ₃ H CH ₃ n-Pr * 1
2-115 3,4,5-Cl ₃ Cl H i-Pr 156.0-157.0
2-116 3,4,5-Cl ₃ Br H i-Pr 135.0-138.0
2-117 3,5-Cl ₂ NO ₂ H i-Pr 176.0-177.0
2-118 3,4,5-Cl ₃ NO ₂ H i-Pr * 1
2-119 3,4,5-Cl ₃ H CH ₃ i-Pr 103.0-107.0
2-120 3,4,5-Cl ₃ HH c-Pr * 1
2-121 3-CF ₃ Cl H c-Pr * 1
2-122 3,4-Cl ₂ -5-CH ₃ Cl H c-Pr 132.0-135.0
2-123 3,5-Cl ₂ -4-OH Cl H c-Pr * 1
2-124 3,5-Cl ₂ -4-OCHF ₂ Cl H c-Pr * 1
2-125 3,5-Cl ₂ -4-OSO ₂ CH ₃ Cl H c-Pr * 1
2-126 3,5-Cl ₂ -4-SCH ₃ Cl H c-Pr * 1
2-127 3,5-Cl ₂ -4-S (O) CH ₃ Cl H c-Pr * 1
2-128 3,5-Cl ₂ -4-SO ₂ CH ₃ Cl H c-Pr * 1
2-129 3,4,5-Cl ₃ Br H c-Pr 128.5-132.0
2-130 3,4,5-Cl ₃ NO ₂ H c-Pr * 1
2-131 3,5-Cl ₂ CN H c-Pr * 1
2-132 3,5-Cl ₂ C (S) NH ₂ H c-Pr * 1
2-133 3,5- (CF ₃ ) ₂ H CH ₃ c-Pr * 1
2-134 3,4,5-Cl ₃ H CH ₃ c-Pr * 1
2-135 3,5-Cl ₂ CH ₃ CH ₃ c-Pr * 1
2-136 3,5-Cl ₂ H c-Pr c-Pr * 1
2-137 3,4,5-Cl ₃ H CN c-Pr 203.0-207.0
2-138 3,4,5-Cl ₃ HC (S) NH ₂ c-Pr * 1
2-139 3,5- (CF ₃ ) ₂ Cl H i-Bu 164.0-166.0
2-140 3,4,5-Cl ₃ Cl H i-Bu * 1
2-141 3,4,5-Cl ₃ Br H i-Bu * 1
2-142 3,4,5-Cl ₃ H CH ₃ i-Bu * 1
2-143 3,5- (CF ₃ ) ₂ Cl H CH ₂ Pr-c 150.0-152.0
2-144 3,4,5-Cl ₃ Cl H CH ₂ Pr-c * 1
2-145 3,4,5-Cl ₃ Br H CH ₂ Pr-c * 1
2-146 3,4,5-Cl ₃ NO ₂ H CH ₂ Pr-c * 1
2-147 3,5- (CF ₃ ) ₂ H CH ₃ CH ₂ Pr-c * 1
2-148 3,4,5-Cl ₃ H CH ₃ CH ₂ Pr-c * 1
2-149 3,4,5-Cl ₃ H CN CH ₂ Pr-c * 1
2-150 3,5- (CF ₃ ) ₂ Cl H T-1 163.0-165.0
2-151 3,4,5-Cl ₃ Cl H T-1 * 1
2-152 3,4,5-Cl ₃ H CH ₃ T-1 130.0-135.0
2-153 3,4,5-Cl ₃ Cl H c-Bu * 1
2-154 3,4,5-Cl ₃ Br H c-Bu * 1
2-155 3,4,5-Cl ₃ Cl H T-2 176.0-178.0
2-156 3,4,5-Cl ₃ Cl H T-3 * 1
2-157 3,5-Cl ₂ Cl H CH ₂ Br 160.0-163.0
2-158 3,4,5-Cl ₃ Cl H CH ₂ Br * 1
2-159 3,4,5-Cl ₃ Cl H CF ₃ * 1
2-160 3,4,5-Cl ₃ Br H CF ₃ * 1
2-161 3,4,5-Cl ₃ Cl H CF ₂ Cl * 1
2-162 3-Cl-4,5- (SCH ₃ ) ₂ Cl H CF ₂ Cl * 1
2-163 3,4,5-Cl ₃ Cl H CH ₂ CH ₂ Cl * 1
2-164 3,4,5-Cl ₃ Cl H CH ₂ CF ₃ * 1
2-165 3,4,5-Cl ₃ Br H CH ₂ CF ₃ 78.5-81.0
2-166 3,4,5-Cl ₃ NO ₂ H CH ₂ CF ₃ 183.0-185.0
2-167 3,4,5-Cl ₃ H CH ₃ CH ₂ CF ₃ * 1
2-168 3,4,5-Cl ₃ H CN CH ₂ CF ₃ * 1
2-169 3,4,5-Cl ₃ Cl H CF ₂ CF ₃ * 1
2-170 3,4,5-Cl ₃ Br H CF ₂ CF ₃ 100.0-112.5
2-171 3,4,5-Cl ₃ Cl H CH ₂ CH ₂ CF ₃ * 1
2-172 3,5-Cl ₂ H CH ₃ CH ₂ CH ₂ CF ₃ 138.0-143.0
2-173 3,4,5-Cl ₃ H CH ₃ CH ₂ CH ₂ CF ₃ * 1
2-174 3,4,5-Cl ₃ Cl H CH ₂ OCH ₂ CF ₃ * 1
2-175 3,4,5-Cl ₃ Cl H CH ₂ OCH ₂ C≡CH * 1
2-176 3,4,5-Cl ₃ HH E-6a * 1
2-177 3,5- (CF ₃ ) ₂ Cl H E-6a 172.0-174.0
2-178 3,4,5-Cl ₃ Cl H E-6a * 1
2-179 3,4,5-Cl ₃ Br H E-6a * 1
2-180 3,4,5-Cl ₃ NO ₂ H E-6a * 1
2-181 3,4,5-Cl ₃ H CH ₃ E-6a * 1
2-182 3,5-Cl ₂ Br H CH ₂ SO ₂ CH ₃ * 1
2-183 3,5-Cl ₂ Cl H CH ₂ SEt * 1
2-184 3,5-Cl ₂ Cl H CH ₂ S (O) Et * 1
2-185 3,5-Cl ₂ Cl H CH ₂ SO ₂ Et * 1
2-186 3,5-Cl ₂ Cl H CH ₂ SPr-n * 1
2-187 3,5-Cl ₂ Cl H CH ₂ SPr-i * 1
2-188 3,5-Cl ₂ Cl H CH ₂ SCH ₂ Ph * 1
2-189 3,5-Cl ₂ Cl H CH ₂ SO ₂ CH ₂ Ph * 1
2-190 3,5-Cl ₂ Cl H CH ₂ SPh * 1
2-191 3,5-Cl ₂ Cl H CH ₂ SO ₂ Ph * 1
2-192 3,5-Cl ₂ Cl H CH (CH ₃ ) SCH ₃ 131.0-133.0
2-193 3,5-Cl ₂ Cl H CH (CH ₃ ) S (O) CH ₃ * 1
2-194 3,5-Cl ₂ Cl H CH (CH ₃ ) SO ₂ CH ₃ * 1
2-195 3,5-Cl ₂ Cl HC (CH ₃ ) ₂ SCH ₃ * 1
2-196 3,5-Cl ₂ Cl HC (CH ₃ ) ₂ SO ₂ CH ₃ * 1
2-197 3,4,5-Cl ₃ Cl H CH ₂ CH ₂ SCH ₃ * 1
2-198 3,4,5-Cl ₃ H CN CH ₂ CH ₂ SCH ₃ * 1
2-199 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₃ ) ₂ * 1
2-200 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₃ ) Et * 1
2-201 3,4,5-Cl ₃ Cl H CH ₂ N (Et) ₂ * 1
2-202 3,4,5-Cl ₃ Cl H CH ₂ NHCH ₂ CF ₃ * 1
2-203 3,4,5-Cl ₃ Cl H CH ₂ NHCH ₂ CN * 1
2-204 3,4,5-Cl ₃ Cl H CH ₂ NHCH ₂ C≡CH * 1
2-205 3,4,5-Cl ₃ Cl H CH ₂ (T-23) * 1
2-206 3,4,5-Cl ₃ Cl H CH ₂ NHC (O) OCH ₃ * 1
2-207 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₃ ) C (O) OCH ₃ * 1
2-208 3,4,5-Cl ₃ Cl H CH ₂ N (Et) C (O) OCH ₃ * 1
2-209 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₂ CN) C (O) OCH ₃ * 1
2-210 3,5-Cl ₂ Cl H (E-21a) H * 1
2-211 3,5-Cl ₂ Cl H (E-21a) C (O) CH ₃ * 1
2-212 3,5-Cl ₂ Cl H (E-21a) C (O) OCH ₃ * 1
2-213 3,5-Cl ₂ Cl H (E-22a) H * 1
2-214 3,5-Cl ₂ Cl H (E-22a) C (O) CH ₃ * 1
2-215 3,4,5-Cl ₃ Cl H CH ₂ CN * 1
2-216 3,4,5-Cl ₃ Cl H CH ₂ CH ₂ C (O) OCH ₃ * 1
2-217 3,4,5-Cl ₃ Cl H CH ₂ C (O) NHCH ₃ * 1
2-218 3,4,5-Cl ₃ Cl H CH ₂ C (O) NHEt * 1
2-219 3,4,5-Cl ₃ Cl H CH ₂ C (O) NHCH ₂ Pr-c * 1
2-220 3,5-Cl ₂ Cl H CH ₂ C (O) NHCH ₂ CF ₃ * 1
2-221 3,4,5-Cl ₃ Cl H CH ₂ C (O) (T-23) * 1
2-222 3,4,5-Cl ₃ Cl H CH = CH ₂ * 1
2-223 3,4,5-Cl ₃ Br H CH = CH ₂ * 1
2-224 3,4,5-Cl ₃ Cl H CH ₂ CH = CH ₂ * 1
2-225 3,4,5-Cl ₃ Cl H CH = CHCH ₃ * 1
2-226 3,4,5-Cl ₃ Cl HC (CH ₃ ) = CH ₂ * 1
2-227 3,4,5-Cl ₃ Cl HC (CF ₃ ) = CH ₂ * 1
2-228 3,4,5-Cl ₃ Cl H CH = CHPh * 1
2-229 3,4,5-Cl ₃ Cl HC≡CH * 1
2-230 3,4,5-Cl ₃ Cl HC≡CCH ₃ * 1
2-231 3,4,5-Cl ₃ Cl H CH ₂ CH ₂ C≡CH * 1
2-232 3,4,5-Cl ₃ Br H CH ₂ CH ₂ C≡CH * 1
2-233 3,4,5-Cl ₃ NO ₂ H CH ₂ CH ₂ C≡CH * 1
2-234 3,4,5-Cl ₃ H CH ₃ CH ₂ CH ₂ C≡CH * 1
2-235 3,4,5-Cl ₃ H CN CH ₂ CH ₂ C≡CH * 1
2-236 3,4,5-Cl ₃ H CH ₃ CH ₂ (Ph-2,4-F ₂ ) * 1
2-237 3,5-Cl ₂ H CH ₃ CH ₂ CH ₂ Ph 151.0-155.0
2-238 3,4,5-Cl ₃ H CH ₃ CH ₂ (D-52a) * 1
2-239 3,5-Cl ₂ Br HC (O) Pr-i * 1
2-240 3,4,5-Cl ₃ Cl HC (O) NHCH ₃ * 1
2-241 3,4,5-Cl ₃ Cl HC (O) NHEt * 1
2-242 3,5-Cl ₂ H CH ₃ Ph 95.0-100.0
2-243 3,5-Cl ₂ H CH ₃ Ph-2-F * 1
2-244 3,5-Cl ₂ H CH ₃ Ph-3-F 136.0-141.0
2-245 3,4,5-Cl ₃ Cl H Ph-4-F * 1
2-246 3,4,5-Cl ₃ Br H Ph-4-F * 1
2-247 3,5-Cl ₂ H CH ₃ Ph-4-F 123.0-128.0
2-248 3,4,5-Cl ₃ Cl H Ph-2-Cl * 1
2-249 3,4,5-Cl ₃ Br H Ph-2-Cl * 1
2-250 3,5-Cl ₂ H CH ₃ Ph-2-Cl * 1
2-251 3,5-Cl ₂ H CH ₃ Ph-3-Cl 131.0-134.0
2-252 3,5-Cl ₂ H CH ₃ Ph-4-Cl 159.0-161.0
2-253 3,4,5-Cl ₃ Br H Ph-2-Br * 1
2-254 3,4,5-Cl ₃ Cl H Ph-2-CH ₃ * 1
2-255 3,4,5-Cl ₃ Cl H Ph-2-CF ₃ * 1
2-256 3,5-Cl ₂ Cl H Ph-4-CF (CF ₃ ) ₂ * 1
2-257 3,5-Cl ₂ Cl H Ph-4-OPh * 1
2-258 3,4,5-Cl ₃ Cl H Ph-2-SCH ₃ * 1
2-259 3,5-Cl ₂ Cl H Ph-4-SCH ₃ * 1
2-260 3,5-Cl ₂ H CH ₃ Ph-4-SO ₂ CH ₃ 163.0-165.0
2-261 3,5-Cl ₂ Cl H Ph-4-SCF ₃ * 1
2-262 3,4,5-Cl ₃ Cl H Ph-2-NO ₂ * 1
2-263 3,4,5-Cl ₃ Cl H Ph-4-NO ₂ * 1
2-264 3,4,5-Cl ₃ Cl H Ph-2-CN * 1
2-265 3,4,5-Cl ₃ Cl H Ph-4-CN * 1
2-266 3,4,5-Cl ₃ H CH ₃ Ph-4-CN * 1
2-267 3,4,5-Cl ₃ Cl H Ph-2,4-F ₂ * 1
2-268 3,4,5-Cl ₃ Br H Ph-2,4-F ₂ * 1
2-269 3,5-Cl ₂ NO ₂ H Ph-2,4-F ₂ * 1
2-270 3,4,5-Cl ₃ NO ₂ H Ph-2,4-F ₂ * 1
2-271 3,5-Cl ₂ H CH ₃ Ph-2,4-F ₂ * 1
2-272 3,4,5-Cl ₃ H CH ₃ Ph-2,4-F ₂ * 1
2-273 3,4,5-Cl ₃ H CN Ph-2,4-F ₂ * 1
2-274 3,5-Cl ₂ Cl H Ph-2,6-F ₂ * 1
2-275 3,4,5-Cl ₃ Cl H Ph-2,6-F ₂ * 1
2-276 3,5-Cl ₂ H CH ₃ Ph-2,6-F ₂ * 1
2-277 3,4,5-Cl ₃ H CH ₃ Ph-2,6-F ₂ * 1
2-278 3,4,5-Cl ₃ Cl H Ph-3,4-F ₂ * 1
2-279 3,4,5-Cl ₃ Cl H Ph-2-Cl-4-F * 1
2-280 3,5-Cl ₂ H CH ₃ Ph-2-Cl-4-F * 1
2-281 3,4,5-Cl ₃ H CH ₃ Ph-2-Cl-4-F * 1
2-282 3,4,5-Cl ₃ Cl H Ph-2-F-4-CN * 1
2-283 3,5-Cl ₂ H CH ₃ Ph-2-F-4-CN * 1
2-284 3,5-Cl ₂ Cl H Ph-2,4,6-F ₃ * 1
2-285 3,5- (CF ₃ ) ₂ Cl H Ph-2,4,6-F ₃ 189.0-191.0
2-286 3,4,5-Cl ₃ Cl H Ph-2,4,6-F ₃ * 1
2-287 3,4,5-Cl ₃ Br H Ph-2,4,6-F ₃ 141.0-144.5
2-288 3,5-Cl ₂ H CH ₃ Ph-2,4,6-F ₃ * 1
2-289 3,5- (CF ₃ ) ₂ H CH ₃ Ph-2,4,6-F ₃ * 1
2-290 3,4,5-Cl ₃ H CH ₃ Ph-2,4,6-F ₃ * 1
2-291 3,4,5-Cl ₃ H CH ₃ Ph-2,3,4,5,6-F ₅ * 1
2-292 3,5-Cl ₂ H CH ₃ (D-1d) Br * 1
2-293 3,5-Cl ₂ Cl H D-3a * 1
2-294 3,4,5-Cl ₃ Cl H (D-3b) Cl * 1
2-295 3,5-Cl ₂ H CH ₃ (D-3b) Cl * 1
2-296 3,4,5-Cl ₃ Cl H (D-16c) Cl * 1
2-297 3,5-Cl ₂ H CH ₃ (D-16c) Cl 115.0-120.0
2-298 3,4,5-Cl ₃ Cl H D-16d 175.0-180.0
2-299 3,4,5-Cl ₃ Cl H (D-17b) Cl * 1
2-300 3,5-Cl ₂ H CH ₃ (D-17b) Cl 161.0-164.0
2-301 3,4,5-Cl ₃ H CH ₃ D-22a * 1
2-302 3,4,5-Cl ₃ Cl H D-24a * 1
2-303 3,5-Cl ₂ Cl H (D-52d) Cl 65.0-70.0
2-304 3,4,5-Cl ₃ Cl H (D-53b) Cl * 1
2-305 3,4,5-Cl ₃ Br H (D-53b) Cl * 1
2-306 3,5-Cl ₂ H CH ₃ (D-53b) Cl * 1
2-307 3,4,5-Cl ₃ H CH ₃ (D-53b) Cl * 1
2-308 3,5-Cl ₂ Cl H (D-53e) Cl * 1
2-309 3,4,5-Cl ₃ Cl H (D-53e) Cl * 1
2-310 3,4,5-Cl ₃ Br H (D-53e) Cl * 1
2-311 3,4,5-Cl ₃ H CH ₃ (D-53e) Cl 125.0-130.0
2-312 3,4,5-Cl ₃ H CH ₃ D-55a * 1
2-313 3,5-Cl ₂ Cl H D-58a * 1
2-314 3,5- (CF ₃ ) ₂ Br H Et * 1
2-315 3,5- (CF ₃ ) ₂ H CH ₃ Et * 1
2-316 3-CF ₃ -4-Cl Cl H n-Pr * 1
2-317 3,5- (CF ₃ ) ₂ Br H n-Pr * 1
2-318 3,5- (CF ₃ ) ₂ H CH ₃ n-Pr * 1
2-319 3,5- (CF ₃ ) ₂ Br H i-Pr * 1
2-320 3,5- (CF ₃ ) ₂ H CH ₃ i-Pr * 1
2-321 3-CF ₃ -4-Cl Cl H c-Pr * 1
2-322 3,5- (CF ₃ ) ₂ Br H c-Pr * 1
2-323 3,5- (CF ₃ ) ₂ H CN c-Pr 157.0-162.0
2-324 3-CF ₃ -4-Cl Cl H CH ₂ Pr-c * 1
2-325 3,5-Cl ₂ -4-OCHF ₂ Cl H CH ₂ Pr-c * 1
2-326 3,5- (CF ₃ ) ₂ Br H CH ₂ Pr-c * 1
2-327 3,5- (CF ₃ ) ₂ H CN CH ₂ Pr-c 137.0-139.0
2-328 3-CF ₃ -4-Cl Cl H CH ₂ CF ₃ * 1
2-329 3-CF ₃ -4-Cl Cl H E-6a * 1
2-330 3,5- (CF ₃ ) ₂ Br H E-6a * 1
2-331 3,5- (CF ₃ ) ₂ H CH ₃ E-6a * 1
2-332 3,4,5-Cl ₃ Cl H CH ₂ NHCH ₂ Pr-c * 1
2-333 3,4,5-Cl ₃ Cl H CH ₂ NHC (O) CF ₃ 176.0-180.0
2-334 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₃ ) C (O) CF ₃ * 1
2-335 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₂ Pr-c) C (O) CF ₃ * 1
2-336 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₂ C≡CH) C (O) CF ₃ * 1
2-337 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₂ Pr-c) C (O) OCH ₃ * 1
2-338 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₂ C≡CH) C (O) OCH ₃ * 1
2-339 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₃ ) C (O) OEt * 1
2-340 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₃ ) C (O) NHEt * 1
2-341 3,4,5-Cl ₃ Cl H CH ₂ C (O) NHPr-n * 1
2-342 3,5- (CF ₃ ) ₂ Cl H CH ₂ CH ₂ C≡CH * 1
2-343 3,5- (CF ₃ ) ₂ Br H CH ₂ CH ₂ C≡CH * 1
2-344 3,5- (CF ₃ ) ₂ H CH ₃ CH ₂ CH ₂ C≡CH * 1
2-345 3-CF ₃ -4-Cl Cl H Ph-2,4,6-F ₃ 137.0-140.0
2-346 3,5-Cl ₂ H CH ₃ T-12 * 1
2-347 3,5- (CF ₃ ) ₂ FH CH ₃ 151.0-153.0
2-348 3-Br-5-CF ₃ Cl H CH ₃ * 1
2-349 3-I-5-CF ₃ Cl H CH ₃ 92.0-94.0
2-350 3,5-Br ₂ -4-F Cl H CH ₃ * 1
2-351 3,5-Br ₂ -4-Cl Cl H CH ₃ * 1
2-352 3-Cl-5-CF ₃ Br H CH ₃ * 1
2-353 3-Br-5-CF ₃ Br H CH ₃ 106.0-107.0
2-354 3,5-Br ₂ -4-F Br H CH ₃ * 1
2-355 3,5-Br ₂ -4-FIH CH ₃ * 1
2-356 3,5- (CF ₃ ) ₂ NO ₂ H CH ₃ * 1
2-357 3-Cl-5-CF ₃ H CH ₃ CH ₃ 148.0-154.0
2-358 3-I-5-CF ₃ H CH ₃ CH ₃ 114.0-116.0
2-359 3,5-Br ₂ -4-FH CH ₃ CH ₃ 131.0-134.0
2-360 3,5- (CF ₃ ) ₂ FH Et * 1
2-361 3-CF ₃ Cl H Et 100.0-103.0
2-362 3-Br-5-CF ₃ Cl H Et * 1
2-363 3-I-5-CF ₃ Cl H Et 138.0-140.0
2-364 3,5-Br ₂ -4-F Cl H Et * 1
2-365 3,5-Br ₂ -4-Cl Cl H Et * 1
2-366 3,4-Cl ₂ -5-CF ₃ Cl H Et * 1
2-367 3-CF ₃ Br H Et 98.0-101.0
2-368 3-Cl-5-CF ₃ Br H Et * 1
2-369 3-Br-5-CF ₃ Br H Et * 1
2-370 3,5-Br ₂ -4-F Br H Et * 1
2-371 3,4-Cl ₂ -5-CF ₃ Br H Et * 1
2-372 3,5- (CF ₃ ) ₂ IH Et 154.0-156.0
2-373 3,5-Br ₂ -4-FIH Et * 1
2-374 3,5- (CF ₃ ) ₂ NO ₂ H Et 103.0-105.0
2-375 3-Cl-5-CF ₃ H CH ₃ Et 97.0-100.0
2-376 3-Br-5-CF ₃ H CH ₃ Et * 1
2-377 3-I-5-CF ₃ H CH ₃ Et 105.0-108.0
2-378 3,5- (CF ₃ ) ₂ H CH ₃ (S) Et * 1
2-379 3,5-Br ₂ -4-FH CH ₃ Et 194.0-197.0
2-380 3,5- (CF ₃ ) ₂ H CN Et * 1
2-381 3,4-Cl ₂ -5-CF ₃ H CN Et 193.0-194.0
2-382 3,5- (CF ₃ ) ₂ Br CN Et 165.0-167.0
2-383 3,5-Cl ₂ CH ₃ CN Et * 1
2-384 3,5- (CF ₃ ) ₂ FH n-Pr * 1
2-385 3-CF ₃ Cl H n-Pr * 1
2-386 3-Br-5-CF ₃ Cl H n-Pr * 1
2-387 3-I-5-CF ₃ Cl H n-Pr 154.0-156.0
2-388 3,5-Br ₂ -4-F Cl H n-Pr * 1
2-389 3,5-Br ₂ -4-Cl Cl H n-Pr * 1
2-390 3,4-Cl ₂ -5-CF ₃ Cl H n-Pr * 1
2-391 3-CF ₃ Br H n-Pr * 1
2-392 3-Cl-5-CF ₃ Br H n-Pr * 1
2-393 3,5-Br ₂ -4-F Br H n-Pr * 1
2-394 3,5- (CF ₃ ) ₂ IH n-Pr 165.0-167.0
2-395 3,5-Br ₂ -4-FIH n-Pr * 1
2-396 3,5- (CF ₃ ) ₂ NO ₂ H n-Pr * 1
2-397 3-Cl-5-CF ₃ H CH ₃ n-Pr 88.0-90.0
2-398 3-I-5-CF ₃ H CH ₃ n-Pr 102.0-105.0
2-399 3,5-Br ₂ -4-FH CH ₃ n-Pr 160.0-162.0
2-400 3,5- (CF ₃ ) ₂ H CN n-Pr 145.0-148.0
2-401 3,5- (CF ₃ ) ₂ FH i-Pr * 1
2-402 3-Br-5-CF ₃ Cl H i-Pr * 1
2-403 3-I-5-CF ₃ Cl H i-Pr 160.0-162.0
2-404 3,5-Br ₂ -4-F Cl H i-Pr * 1
2-405 3,5-Br ₂ -4-Cl Cl H i-Pr * 1
2-406 3,4-Cl ₂ -5-CF ₃ Cl H i-Pr * 1
2-407 3-Cl-5-CF ₃ Br H i-Pr * 1
2-408 3-Br-5-CF ₃ Br H i-Pr * 1
2-409 3,5-Br ₂ -4-F Br H i-Pr * 1
2-410 3,4-Cl ₂ -5-CF ₃ Br H i-Pr * 1
2-411 3,5- (CF ₃ ) ₂ IH i-Pr 150.0-152.0
2-412 3,5-Br ₂ -4-FIH i-Pr * 1
2-413 3,5- (CF ₃ ) ₂ NO ₂ H i-Pr * 1
2-414 3-Cl-5-CF ₃ H CH ₃ i-Pr 109.0-113.0
2-415 3-Br-5-CF ₃ H CH ₃ i-Pr 125.0-127.0
2-416 3-I-5-CF ₃ H CH ₃ i-Pr 125.0-127.0
2-417 3,5-Br ₂ -4-FH CH ₃ i-Pr 177.0-179.0
2-418 3,5- (CF ₃ ) ₂ H CN i-Pr * 1
2-419 3,5- (CF ₃ ) ₂ FH c-Pr * 1
2-420 3-Br-4-F Cl H c-Pr * 1
2-421 3-Br-5-CF ₃ Cl H c-Pr * 1
2-422 3-I-5-CF ₃ Cl H c-Pr 179.0-181.0
2-423 3,5-Br ₂ -4-F Cl H c-Pr * 1
2-424 3,5-Br ₂ -4-Cl Cl H c-Pr * 1
2-425 3,4-Cl ₂ -5-CF ₃ Cl H c-Pr * 1
2-426 3-CF ₃ Br H c-Pr * 1
2-427 3-Cl-5-CF ₃ Br H c-Pr * 1
2-428 3-Br-5-CF ₃ Br H c-Pr 170.0-172.0
2-429 3,5-Br ₂ -4-F Br H c-Pr * 1
2-430 3,4-Cl ₂ -5-CF ₃ Br H c-Pr * 1
2-431 3,5- (CF ₃ ) ₂ IH c-Pr 160.0-161.0
2-432 3,5-Br ₂ -4-FIH c-Pr * 1
2-433 3,5- (CF ₃ ) ₂ C≡CH H c-Pr * 1
2-434 3,5- (CF ₃ ) ₂ CN H c-Pr 147.0-148.0
2-435 3,5- (CF ₃ ) ₂ NO ₂ H c-Pr * 1
2-436 3-Cl-5-CF ₃ H CH ₃ c-Pr 105.0-108.0
2-437 3-Br-5-CF ₃ H CH ₃ c-Pr * 1
2-438 3-I-5-CF ₃ H CH ₃ c-Pr 124.0-126.0
2-439 3,5- (CF ₃ ) ₂ H CH ₃ (S) c-Pr * 1
2-440 3,5-Br ₂ -4-FH CH ₃ c-Pr 208.0-210.0
2-441 3,4-Cl ₂ -5-CF ₃ H CH ₃ c-Pr * 1
2-442 3,5- (CF ₃ ) ₂ Br CH ₃ c-Pr 101.0-105.0
2-443 3,5- (CF ₃ ) ₂ I CH ₃ c-Pr 177.0-179.0
2-444 3,5- (CF ₃ ) ₂ NO ₂ CH ₃ c-Pr 172.0-175.0
2-445 3,5-Cl ₂ H CH ₂ SCH ₃ c-Pr * 1
2-446 3,5- (CF ₃ ) ₂ HC≡CH c-Pr * 1
2-447 3,4-Cl ₂ -5-CF ₃ H CN c-Pr 185.0-186.0
2-448 3,5- (CF ₃ ) ₂ Cl CN c-Pr * 1
2-449 3,5- (CF ₃ ) ₂ Br CN c-Pr * 1
2-450 3,5-Cl ₂ I CN c-Pr * 1
2-451 3,5- (CF ₃ ) ₂ I CN c-Pr * 1
2-452 3,5-Cl ₂ CH ₃ CN c-Pr * 1
2-453 3,5-Cl ₂ HC (O) NH ₂ c-Pr * 1
2-454 3,5- (CF ₃ ) ₂ FH i-Bu * 1
2-455 3-Br-5-CF ₃ Cl H i-Bu * 1
2-456 3-I-5-CF ₃ Cl H i-Bu 162.0-164.0
2-457 3,5-Br ₂ -4-F Cl H i-Bu * 1
2-458 3,5-Br ₂ -4-Cl Cl H i-Bu * 1
2-459 3,4-Cl ₂ -5-CF ₃ Cl H i-Bu * 1
2-460 3-Cl-5-CF ₃ Br H i-Bu 148.0-150.0
2-461 3-Br-5-CF ₃ Br H i-Bu * 1
2-462 3,5-Br ₂ -4-F Br H i-Bu * 1
2-463 3,4-Cl ₂ -5-CF ₃ Br H i-Bu * 1
2-464 3,5-Br ₂ -4-FIH i-Bu * 1
2-465 3,5- (CF ₃ ) ₂ NO ₂ H i-Bu * 1
2-466 3-Cl-5-CF ₃ H CH ₃ i-Bu 98.0-100.0
2-467 3-Br-5-CF ₃ H CH ₃ i-Bu 104.0-107.0
2-468 3-I-5-CF ₃ H CH ₃ i-Bu 103.0-105.0
2-469 3,5-Br ₂ -4-FH CH ₃ i-Bu 167.0-170.0
2-470 3-CF ₃ Cl H CH ₂ Pr-c * 1
2-471 3-Br-5-CF ₃ Cl H CH ₂ Pr-c 124.0-127.0
2-472 3-I-5-CF ₃ Cl H CH ₂ Pr-c 148.0-150.0
2-473 3,5-Br ₂ -4-F Cl H CH ₂ Pr-c * 1
2-474 3,5-Br ₂ -4-Cl Cl H CH ₂ Pr-c * 1
2-475 3-CF ₃ Br H CH ₂ Pr-c * 1
2-476 3-Cl-5-CF ₃ Br H CH ₂ Pr-c * 1
2-477 3-Br-5-CF ₃ Br H CH ₂ Pr-c 152.0-153.0
2-478 3,5- (CF ₃ ) ₂ IH CH ₂ Pr-c 160.0-161.0
2-479 3-Cl-5-CF ₃ H CH ₃ CH ₂ Pr-c * 1
2-480 3-I-5-CF ₃ H CH ₃ CH ₂ Pr-c * 1
2-481 3,5- (CF ₃ ) ₂ H CH ₃ (R) CH ₂ Pr-c 97.0-98.0
[α] _D ^20.0 + 31.70 ° (CH ₃ CN, c = 1.217)
2-482 3,5- (CF ₃ ) ₂ H CH ₃ (S) CH ₂ Pr-c 97.0-99.0
[α] _D ^20.0 -32.92 ° (CH ₃ CN, c = 1.253)
2-483 3,5-Cl ₂ Cl CN CH ₂ Pr-c * 1
2-484 3,5-Cl ₂ CH ₃ CN CH ₂ Pr-c * 1
2-485 3-Br-5-CF ₃ Cl H s-Bu 154.0-157.5
2-486 3,5- (CF ₃ ) ₂ Cl H CHBr ₂ 107.0-109.0
2-487 3-I-5-CF ₃ Cl H CH ₂ CF ₃ 174.0-176.0
2-488 3-Cl-5-CF ₃ Br H CH ₂ CF ₃ 150.0-152.0
2-489 3-Cl-5-CF ₃ H CH ₃ CH ₂ CF ₃ 127.0-128.0
2-490 3-I-5-CF ₃ H CH ₃ CH ₂ CF ₃ 154.0-156.0
2-491 3,5- (CF ₃ ) ₂ Cl H T-7 * 1
2-492 3,5- (CF ₃ ) ₂ Cl H E-5a * 1
2-493 3-CF ₃ Cl H E-6a 133.0-136.5
2-494 3-Br-5-CF ₃ Cl H E-6a 152.5-156.0
2-495 3-I-5-CF ₃ Cl H E-6a 184.0-186.0
2-496 3-Cl-5-CF ₃ Br H E-6a 160.0-163.0
2-497 3-Br-5-CF ₃ Br H E-6a 173.0-175.0
2-498 3,5- (CF ₃ ) ₂ IH E-6a * 1
2-499 3,5- (CF ₃ ) ₂ NO ₂ H E-6a * 1
2-500 3-Cl-5-CF ₃ H CH ₃ E-6a * 1
2-501 3,5- (CF ₃ ) ₂ H CN E-6a * 1
2-502 3,5-Cl ₂ CH ₃ CN CH ₂ SEt * 1
2-503 3,5-Cl ₂ CH ₃ CN CH ₂ S (O) Et * 1
2-504 3,5-Cl ₂ CH ₃ CN CH ₂ SO ₂ Et * 1
2-505 3,5-Cl ₂ CH ₃ CN CH ₂ S (O) (Et) = NH * 1
2-506 3,5- (CF ₃ ) ₂ Cl H T-41 * 1
2-507 3,5- (CF ₃ ) ₂ Cl H CH ₂ (E-27a) * 1
2-508 3,5- (CF ₃ ) ₂ Cl H CH ₂ (E-27b) * 1
2-509 3,5- (CF ₃ ) ₂ Cl H CH ₂ (E-27c) * 1
2-510 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₃ ) C (O) CH ₃ * 1
2-511 3,5- (CF ₃ ) ₂ Cl H CH ₂ N (CH ₃ ) C (O) CH ₂ OCH ₃ * 1
2-512 3,5- (CF ₃ ) ₂ Cl H CH ₂ N (CH ₃ ) C (O) OCH ₃ * 1
2-513 3,4,5-Cl ₃ Cl H CH ₂ N (Pr-c) C (O) OCH ₃ * 1
2-514 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₃ ) C (O) OPr-i * 1
2-515 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₃ ) C (O) SCH ₃ * 1
2-516 3,4,5-Cl ₃ Cl H CH ₂ N (CH ₃ ) SO ₂ CH ₃ * 1
2-517 3,5- (CF ₃ ) ₂ Cl H CH ₂ N (CH ₃ ) SO ₂ CF ₃ 181.0-187.0
2-518 3,4,5-Cl ₃ Cl H CH (CH ₃ ) NHCH ₃ * 1
2-519 3,4,5-Cl ₃ Cl H CH (CH ₃ ) N (CH ₃ ) C (O) OCH ₃ * 1
2-520 3,5- (CF ₃ ) ₂ Cl H (M-7a) CH ₃ * 1
2-521 3,4,5-Cl ₃ Cl H CH ₂ C (O) NH ₂ * 1
2-522 3,5- (CF ₃ ) ₂ Cl H CH ₂ C (NH ₂ ) = NOH * 1
2-523 3,4,5-Cl ₃ Cl H CH ₂ C (NH ₂ ) = NOEt * 1
2-524 3,4,5-Cl ₃ Cl H CH ₂ C (= NOEt) NHC (O) CF ₃ 156.0-158.0
2-525 3,5- (CF ₃ ) ₂ Cl H CH ₂ CH = CH ₂ 140.0-141.0
2-526 3-CF ₃ Cl H CH ₂ CH ₂ C≡CH 91.0-93.5
2-527 3,5- (CF ₃ ) ₂ IH CH ₂ CH ₂ C≡CH * 1
2-528 3,5- (CF ₃ ) ₂ H CN CH ₂ CH ₂ C≡CH * 1
2-529 3,5- (CF ₃ ) ₂ Cl H CH ₂ (D-3a) 175.0-178.0
2-530 3,5- (CF ₃ ) ₂ Cl H CH ₂ (D-3e) 189.0-191.0
2-531 3-CF ₃ Cl H Ph-2,4,6-F ₃ 128.0-131.0
2-532 3-CF ₃ Br H Ph-2,4,6-F ₃ 159.0-161.0
2-533 3,5- (CF ₃ ) ₂ Cl H D-24a * 1
2-534 3-Br-5-CF ₃ Cl H (D-53b) Cl * 1
2-535 3-I-5-CF ₃ Cl H (D-53b) Cl * 1
2-536 3-Cl-5-CF ₃ Br H (D-53b) Cl * 1
2-537 3-Cl-5-CF ₃ IH CH ₃ * 1
2-538 3-I-5-CF ₃ IH CH ₃ 138.0-140.0
2-539 3-Cl-5-CF ₃ IH Et * 1
2-540 3-I-5-CF ₃ IH Et 163.0-166.0
2-541 3-Cl-5-CF ₃ IH n-Pr 148.0-150.0
2-542 3-Cl-5-CF ₃ IH i-Pr 170.0-173.0
2-543 3-Cl-5-CF ₃ IH c-Pr 150.0-152.0
2-544 3-I-5-CF ₃ IH c-Pr 198.0-200.0
2-545 3-Cl-5-CF ₃ IH i-Bu 153.0-155.0
―――――――――――――――――――――――――――――――――――――――
Table 7

―――――――――――――――――――――――――――――――――――――――
No. (X) _m YR ⁴ W ² R ^1b mp (℃)
―――――――――――――――――――――――――――――――――――――――
3-001 3,5-Cl ₂ HHO CH ₃ 122.0-124.0
3-002 3,5-Cl ₂ HHO i-Bu 108.0-110.0
3-003 3,5-Cl ₂ HHO CH ₂ CH ₂ Cl * 2
3-004 3,5-Cl ₂ Cl HO CH ₂ CF ₃ * 1
3-005 3,5-Cl ₂ Cl HS Et 122.0-124.0
3-006 3,4,5-Cl ₃ NO ₂ HO t-Bu * 1
3-007 3,4,5-Cl ₃ Cl HO CH ₂ CF ₃ * 1
3-008 3,5-Cl ₂ Br HO CH ₂ CF ₃ * 1
3-009 3,4,5-Cl ₃ H CH ₃ O CH ₂ CF ₃ * 1
3-010 3,4,5-Cl ₃ Cl HO CH ₂ C≡CH * 1
3-011 3,4,5-Cl ₃ Cl HS CH ₃ * 1
3-012 3,4,5-Cl ₃ Cl HS Et * 1
3-013 3,5- (CF ₃ ) ₂ Br HS CH ₃ * 1
3-014 3,5- (CF ₃ ) ₂ H CH ₃ (R) O t-Bu * 1
3-015 3,5- (CF ₃ ) ₂ H CH ₃ (S) O t-Bu * 1
―――――――――――――――――――――――――――――――――――――――
Table 8

―――――――――――――――――――――――――――――――――――――――
No. (X) _m YR ⁴ R ^1d R ^1c mp (℃)
―――――――――――――――――――――――――――――――――――――――
4-001 3,5-Cl ₂ HHH CH ₂ CF ₃ * 1
4-002 3,5-Cl ₂ H CH ₃ H Et * 2
4-003 3,5-Cl ₂ H CH ₃ H i-Pr * 1
4-004 3,5-Cl ₂ H CH ₃ H CH ₂ CH ₂ Cl * 1
4-005 3,5-Cl ₂ H CN H Et 169.0-170.0
4-006 3,5-Cl ₂ H CN H i-Pr 172.0-175.0
4-007 3,5-Cl ₂ Cl HH OCH ₃ * 2
4-008 3,5-Cl ₂ Br HH CH ₂ CF ₃ 202.0-204.0
4-009 3,5-Cl ₂ IHH CH ₂ CF ₃ * 1
4-010 3,5-Cl ₂ CH ₃ HH Et 128.0-132.0
4-011 3,5-Cl ₂ Cl H CH ₃ CH ₃ * 2
4-012 3,5-Cl ₂ Cl HH c-Pr * 1
4-013 3,5-Cl ₂ Cl HH CH ₂ CF ₃ * 1
4-014 3,5-Cl ₂ Cl HHH * 1
4-015 3,4,5-Cl ₃ Cl HH Et * 1
4-016 3,5-Cl ₂ Br HH Et * 1
4-017 3,4,5-Cl ₃ H CH ₃ H Et * 1
4-018 3,4,5-Cl ₃ Cl H Et Et * 1
4-019 3,4,5-Cl ₃ NO ₂ H Et Et * 1
4-020 3,4,5-Cl ₃ Cl HH i-Pr * 1
4-021 3,5-Cl ₂ Br HH i-Pr * 1
4-022 3,4,5-Cl ₃ H CH ₃ H i-Pr * 1
4-023 3,5- (CF ₃ ) ₂ Cl HH c-Pr * 1
4-024 3,4,5-Cl ₃ Cl HH c-Pr * 1
4-025 3,4,5-Cl ₃ Br HH c-Pr * 1
4-026 3,4,5-Cl ₃ NO ₂ HH c-Pr 157.0-161.0
4-027 3,5- (CF ₃ ) ₂ H CH ₃ H c-Pr * 1
4-028 3,4,5-Cl ₃ H CH ₃ H c-Pr * 1
4-029 3,4,5-Cl ₃ Cl HH i-Bu * 1
4-030 3,5-Cl ₂ Cl HH CH ₂ Pr-c * 1
4-031 3,4,5-Cl ₃ Cl HH CH ₂ Pr-c * 1
4-032 3,4,5-Cl ₃ Cl HH c-Bu * 1
4-033 3,4,5-Cl ₃ Cl HH CH ₂ Bu-t * 1
4-034 3,4,5-Cl ₃ Cl HH c-Pen * 1
4-035 3,4,5-Cl ₃ H CH ₃ H CH ₂ CH ₂ Cl * 1
4-036 3,4,5-Cl ₃ Cl HH CH ₂ CF ₃ * 1
4-037 3,4,5-Cl ₃ Br HH CH ₂ CF ₃ 193.0-196.0
4-038 3,4,5-Cl ₃ NO ₂ HH CH ₂ CF ₃ 229.0-231.0
4-039 3,4,5-Cl ₃ H CH ₃ H CH ₂ CF ₃ * 1
4-040 3,4,5-Cl ₃ Cl HH CH ₂ CH ₂ OCH ₃ * 1
4-041 3,4,5-Cl ₃ Cl HH CH ₂ CH ₂ SCH ₃ * 1
4-042 3,4,5-Cl ₃ Cl HH CH ₂ CH ₂ SO ₂ CH ₃ 228.0-231.0
4-043 3,4,5-Cl ₃ Cl HH CH ₂ CH ₂ SEt * 1
4-044 3,4,5-Cl ₃ Cl HH CH ₂ CH ₂ SO ₂ Et * 1
4-045 3,4,5-Cl ₃ Cl HH CH ₂ CH ₂ N (CH ₃ ) ₂ * 1
4-046 3,4,5-Cl ₃ Cl HH CH ₂ CN 217.0-220.0
4-047 3,4,5-Cl ₃ Cl HH CH ₂ C (O) OCH ₃ * 1
4-048 3,4,5-Cl ₃ Cl HH CH ₂ C (O) OEt * 1
4-049 3,4,5-Cl ₃ Br HH CH ₂ C (O) NHCH ₂ CF ₃ * 1
4-050 3,4,5-Cl ₃ Cl HH CH ₂ Si (CH ₃ ) ₃ * 1
4-051 3,4,5-Cl ₃ Cl HH CH ₂ CH = CH ₂ * 1
4-052 3,5-Cl ₂ Cl HH CH ₂ C≡CH * 1
4-053 3,4,5-Cl ₃ Cl HH CH ₂ C≡CH * 1
4-054 3,4,5-Cl ₃ NO ₂ HH CH ₂ C≡CH 128.0-131.0
4-055 3,4,5-Cl ₃ H CH ₃ H CH ₂ C≡CH * 1
4-056 3,4,5-Cl ₃ Cl H CH ₃ CH ₂ C≡CH * 1
4-057 3,4,5-Cl ₃ Cl HH CH ₂ Ph * 1
4-058 3,4,5-Cl ₃ H CH ₃ H CH ₂ Ph * 1
4-059 3,4,5-Cl ₃ Cl HH CH ₂ (Ph-2-F) 161.0-165.0
4-060 3,4,5-Cl ₃ Cl HH CH ₂ (Ph-3-F) 188.0-191.0
4-061 3,4,5-Cl ₃ Cl HH CH ₂ (Ph-4-F) 193.0-195.0
4-062 3,4,5-Cl ₃ Cl HH CH ₂ (Ph-4-Cl) * 1
4-063 3,4,5-Cl ₃ Cl HH CH ₂ (Ph-2-CF ₃ ) * 1
4-064 3,4,5-Cl ₃ Cl HH CH ₂ (Ph-3-CF ₃ ) * 1
4-065 3,4,5-Cl ₃ Cl HH CH ₂ (Ph-4-CF ₃ ) * 1
4-066 3,4,5-Cl ₃ Cl HH CH ₂ (D-1d) CH ₃ * 1
4-067 3,4,5-Cl ₃ Cl HH CH ₂ (D-3a) * 1
4-068 3,4,5-Cl ₃ Cl HH CH ₂ (D-22a) 232.0-236.0
4-069 3,4,5-Cl ₃ Cl HH CH ₂ (D-52a) * 1
4-070 3,4,5-Cl ₃ H CH ₃ H CH ₂ (D-52a) * 1
4-071 3,4,5-Cl ₃ Cl HH CH ₂ (D-53a) * 1
4-072 3,4,5-Cl ₃ Cl HH CH ₂ (D-54a) * 1
4-073 3,4,5-Cl ₃ H CH ₃ H CH (CN) Ph 106.5-109.0
4-074 3,4,5-Cl ₃ Cl H -CH ₂ CH ₂ CH ₂ CH _2- * 1
4-075 3,4,5-Cl ₃ H CH ₃ -CH ₂ CH ₂ CH ₂ CH _2- * 1
4-076 3,4,5-Cl ₃ Cl H -CH [C (O) OCH ₃ ] CH ₂ CH ₂ CH _2- * 1
4-077 3,4,5-Cl ₃ Cl H -CH [C (O) NHCH ₃ ] CH ₂ CH ₂ CH _2- * 1
4-078 3,4,5-Cl ₃ Cl H -CH ₂ CH ₂ CH ₂ CH ₂ CH _2- * 1
_{4-079 3,4,5-Cl 3 Cl H -CH} 2 CH 2 OCH 2 CH 2 - 114.0-116.0
4-080 3,5-Cl ₂ Cl H -CH ₂ CH ₂ SCH _2- * 1
4-081 3,4,5-Cl ₃ Cl H -CH ₂ CH ₂ SCH ₂ CH _2- * 1
4-082 3,4,5-Cl ₃ Cl H -CH ₂ CH ₂ S (O) CH ₂ CH _2- * 1
4-083 3,4,5-Cl ₃ Cl H -CH ₂ CH ₂ SO ₂ CH ₂ CH _2- * 1
4-084 3,4,5-Cl ₃ H CH ₃ -CH ₂ CH ₂ SCH ₂ CH _2- * 1
4-085 3,4,5-Cl ₃ H CH ₃ -CH ₂ CH ₂ N (Ph) CH ₂ CH _2- * 1
4-086 3,4,5-Cl ₃ Cl H -CH ₂ CH ₂ CH ₂ C (O)-* 1
4-087 3,4,5-Cl ₃ Cl HHC (O) OCH ₃ * 1
4-088 3,5-Cl ₂ Cl H -CH ₂ CH ₂ OC (O)-* 1
4-089 3,4,5-Cl ₃ Cl HH M-14a * 1
4-090 3,4,5-Cl ₃ Cl HH Ph * 1
4-091 3,4,5-Cl ₃ Cl HH Ph-4-F 193.0-195.0
4-092 3,4,5-Cl ₃ Cl HH Ph-4-Cl 208.0-210.0
4-093 3,4,5-Cl ₃ Cl HH Ph-2-CF ₃ * 1
4-094 3,4,5-Cl ₃ Cl HH Ph-4-CF ₃ * 1
4-095 3,4,5-Cl ₃ Cl HH Ph-4-OCH ₃ 185.0-187.0
4-096 3,4,5-Cl ₃ Cl HH OCH ₃ * 1
4-097 3,4,5-Cl ₃ Cl H CH ₃ OCH ₃ * 1
4-098 3,5-Cl ₂ Cl HH OEt * 1
4-099 3,5-Cl ₂ Cl HH SO ₂ CH ₃ * 1
4-100 3,4,5-Cl ₃ Cl HH NH ₂ * 1
4-101 3,4,5-Cl ₃ Cl H Et NH ₂ * 1
4-102 3,4,5-Cl ₃ Cl H t-Bu NH ₂ * 1
4-103 3,4,5-Cl ₃ Cl H CH ₂ Ph NH ₂ * 1
4-104 3,5-Cl ₂ Cl HHN (CH ₃ ) ₂ * 1
4-105 3,4,5-Cl ₃ Cl HHN (CH ₃ ) ₂ * 1
4-106 3,4,5-Cl ₃ H CH ₃ HN (CH ₃ ) ₂ * 1
4-107 3,4,5-Cl ₃ Cl HH NHBu-t * 1
4-108 3,4,5-Cl ₃ Cl HH T-37 * 1
4-109 3,4,5-Cl ₃ Cl HH NHC (O) CH ₃ 128.0-130.0
4-110 3,4,5-Cl ₃ Cl HH NHC (O) Pr-n * 1
4-111 3,4,5-Cl ₃ Cl HH NHC (O) Pr-i * 1
4-112 3,4,5-Cl ₃ Cl HH NHC (O) Ph 130.0-133.0
4-113 3,5- (CF ₃ ) ₂ Cl HH NHC (O) OCH ₃ * 1
4-114 3,4,5-Cl ₃ Cl HH NHC (O) OCH ₃ * 1
4-115 3,4,5-Cl ₃ Cl HH NHC (O) OEt 103.0-107.0
4-116 3,4,5-Cl ₃ Cl HH NHC (O) NH ₂ * 1
4-117 3,4,5-Cl ₃ Cl HH NHC (S) NHCH ₃ 210.0-213.0
4-118 3,4,5-Cl ₃ Cl HHN (CH ₃ ) Ph * 1
4-119 3,4,5-Cl ₃ Cl HH NH (Ph-4-CH ₃ ) * 1
4-120 3,5- (CF ₃ ) ₂ Cl HH Et * 1
4-121 3,5- (CF ₃ ) ₂ Br HH Et * 1
4-122 3,5- (CF ₃ ) ₂ H CH ₃ H Et * 1
4-123 3-CF ₃ -4-Cl Cl HH c-Pr * 1
4-124 3,5- (CF ₃ ) ₂ Br HH c-Pr * 1
4-125 3,5- (CF ₃ ) ₂ IHH c-Pr 177.0-181.0
4-126 3-CF ₃ -4-Cl Cl HH CH ₂ CF ₃ 214.0-216.0
4-127 3,5- (CF ₃ ) ₂ Cl HH CH ₂ C≡CH * 1
4-128 3,5- (CF ₃ ) ₂ Br HH CH ₂ C≡CH * 1
4-129 3,5- (CF ₃ ) ₂ H CH ₃ H CH ₂ C≡CH * 1
4-130 3,5- (CF ₃ ) ₂ FHH Et * 1
4-131 3-Br-5-CF ₃ Cl HH Et * 1
4-132 3,5-Br ₂ -4-F Cl HH Et * 1
4-133 3,5-Br ₂ -4-Cl Cl HH Et * 1
4-134 3,4-Cl ₂ -5-CF ₃ Cl HH Et * 1
4-135 3-Br-5-CF ₃ Br HH Et * 1
4-136 3,4-Cl ₂ -5-CF ₃ Br HH Et * 1
4-137 3,5- (CF ₃ ) ₂ IHH Et * 1
4-138 3-Br-5-CF ₃ H CH ₃ H Et * 1
4-139 3,5-Br ₂ -4-FH CH ₃ H Et * 1
4-140 3,5- (CF ₃ ) ₂ H CN H Et * 1
4-141 3,5- (CF ₃ ) ₂ H CH ₃ (S) H c-Pr * 1
4-142 3,4-Cl ₂ -5-CF ₃ H CH ₃ H c-Pr * 1
4-143 3,5- (CF ₃ ) ₂ IHH CH ₂ C≡CH 169.0-171.0
4-144 3,5-Cl ₂ Cl HH CH = NOCH ₃ 230.0-231.0
4-145 3,5-Cl ₂ Cl H -CH [N (CH ₃ ) ₂ ]-* 1
4-146 3,5- (CF ₃ ) ₂ Br H CH ₃ SO ₂ CH ₃ * 1
4-147 3,5- (CF ₃ ) ₂ Br H -CH (CH ₃ ) CH ₂ CH ₂ SO _2- * 1
―――――――――――――――――――――――――――――――――――――――
Table 9

―――――――――――――――――――――――――――――――――――――――
No. (X) _m A ¹ A ² A ⁴ R ⁴ R ¹ mp (℃)
―――――――――――――――――――――――――――――――――――――――
5-001 3,4,5-Cl ₃ N CH CH HC (O) Pr-c * 1
5-002 3,4,5-Cl ₃ N (O) CH CH HC (O) Pr-c * 1
5-003 3,5-Cl ₂ N CH CH CH ₃ C (O) Pr-c 196.0-200.0
5-004 3,4,5-Cl ₃ CH N CH CH ₃ C (O) Pr-c * 1
5-005 3,5-Cl ₂ CCl CH NHC (O) Pr-c 136.0-138.0
5-006 3,5-Cl ₂ CCH = CHCH = CHC CH HC (O) Pr-c 199.0-201.0
5-007 3,5-Cl ₂ N CH CH CH ₃ C (O) CH ₂ CF ₃ 185.0-192.0
5-008 3,5-Cl ₂ CH CH CH HC (S) CH ₂ CF ₃ * 1
5-009 3,5-Cl ₂ N CH CH CH ₃ C (O) CH ₂ SCH ₃ * 1
5-010 3,5-Cl ₂ CCH = CHCH = CHC CH HC (O) (Ph-2,4-F ₂ ) 169.0-171.0
5-011 3,4,5-Cl ₃ N CH CH HC (O) (Ph-2,4,6-F ₃ ) * 1
5-012 3,5-Cl ₂ N CH CH CH ₃ C (O) (Ph-2,4,6-F ₃ ) 97.0-101.0
5-013 3,4,5-Cl ₃ CH N CH CH ₃ C (O) (Ph-2,4,6-F ₃ ) * 1
5-014 3,5-Cl ₂ CCl CH CH HC (S) OCH ₂ CF ₃ * 1
5-015 3,5-Cl ₂ CCl CH CH HC (S) SCH ₃ * 1
5-016 3,4,5-Cl ₃ CCl CH CH HC (S) NHCH ₃ * 1
5-017 3,4,5-Cl ₃ CCl CH CH HC (S) NHPr-c * 1
5-018 3,4,5-Cl ₃ CH CH CH CH ₃ C (S) NHPr-c * 1
5-019 3,4,5-Cl ₃ CCl CH CH HC (S) NHBu-s * 1
5-020 3,4,5-Cl ₃ CH N CH CH ₃ C (O) NHCH ₂ CF ₃ * 1
5-021 3,4,5-Cl ₃ CCl CH CH HC (S) NHCH ₂ Ph * 1
5-022 3,4,5-Cl ₃ CCl CH CH HC (S) NHC (O) OEt * 1
―――――――――――――――――――――――――――――――――――――――
Table 10

―――――――――――――――――――――――――――――――――――――――
No. (X) _m YR ⁴ R ^1b mp (℃)
―――――――――――――――――――――――――――――――――――――――
6-001 3,5-Cl ₂ HH Et 139.0-141.0
6-002 3,5-Cl ₂ H CH ₃ Ph-2,4-F ₂ * 1
6-003 3,4,5-Cl ₃ H CH ₃ Ph-2,4-F ₂ * 1
―――――――――――――――――――――――――――――――――――――――
Table 11

―――――――――――――――――――――――――――――――――――――――
No. (X) _m YR ⁴ R ² R ¹ mp (℃)
―――――――――――――――――――――――――――――――――――――――
7-001 3,5-Cl ₂ HH -C (O) CH ₂ CH (Ph) C (O)-* 1
7-002 3,5-Cl ₂ H CH ₃ -C (O) CH ₂ CH ₂ C (O)-191.0-194.0
7-003 3,5-Cl ₂ Cl H Et C (O) Pr-c * 1
7-004 3,5-Cl ₂ Cl H OCH ₃ C (O) Pr-c * 1
7-005 3,5-Cl ₂ Cl H OEt C (O) Pr-c * 1
7-006 3,5-Cl ₂ Cl H CH ₂ CF ₃ C (O) CH ₃ * 1
7-007 3,5-Cl ₂ Cl H CH ₂ CF ₃ C (O) Et * 1
7-008 3,5-Cl ₂ Cl H c-Pr C (O) Pr-c * 1
7-009 3,5-Cl ₂ Cl H CH ₂ Pr-c C (O) Pr-c * 1
7-010 3,5-Cl ₂ Cl H CH ₂ CF ₃ C (O) Pr-c * 1
7-011 3,5-Cl ₂ Cl H CH ₂ CH ₂ OCH ₃ C (O) Pr-c * 1
7-012 3,5-Cl ₂ Cl H CH ₃ C (O) Pr-c * 1
7-013 3,5-Cl ₂ Cl H CH ₂ OCH ₃ C (O) Pr-c * 1
7-014 3,5-Cl ₂ Cl HC (O) OCH ₃ C (O) Pr-c 163.0-165.0
7-015 3,5-Cl ₂ Cl H CH ₂ C (O) NHCH ₂ CF ₃ C (O) Pr-c * 1
7-016 3,5-Cl ₂ Cl H (D-52d) Cl C (O) Pr-c * 1
7-017 3,5-Cl ₂ Cl H CH ₃ C (O) CH ₂ Pr-c * 1
7-018 3,5-Cl ₂ Cl H CH ₂ C (O) NHCH ₂ CF ₃ C (O) OCH ₃ * 1
7-019 3,4,5-Cl ₃ H CH ₃ C (O) Et C (O) Et * 1
7-020 3,4,5-Cl ₃ Cl H CH ₃ C (O) Pr-n * 1
7-021 3,4,5-Cl ₃ Cl H CH ₃ C (O) Pr-c * 1
7-022 3,4,5-Cl ₃ Cl H Et C (O) Pr-c * 1
7-023 3,4,5-Cl ₃ H CH ₃ Et C (O) Pr-c * 1
7-024 3,4,5-Cl ₃ Cl H CH ₂ Pr-c C (O) Pr-c * 1
7-025 3,4,5-Cl ₃ H CH ₃ CH ₂ Pr-c C (O) Pr-c * 1
7-026 3,4,5-Cl ₃ Cl H CH ₂ OCH ₃ C (O) Pr-c * 1
7-027 3,5-Cl ₂ Cl H CH ₂ CH ₂ SCH ₃ C (O) Pr-c * 1
7-028 3,4,5-Cl ₃ Cl H CH ₂ CN C (O) Pr-c * 1
7-029 3,4,5-Cl ₃ H CH ₃ CH ₂ C (O) OCH ₃ C (O) Pr-c * 1
7-030 3,4,5-Cl ₃ Cl H CH ₂ C≡CH C (O) Pr-c * 1
7-031 3,4,5-Cl ₃ Cl H CN C (O) Pr-c * 1
7-032 3,5-Cl ₂ Br HC (O) OBu-t C (O) Pr-c * 1
7-033 3,5-Cl ₂ IHC (O) OBu-t C (O) Pr-c * 1
7-034 3,5-Cl ₂ CN HC (O) OBu-t C (O) Pr-c * 1
7-035 3,5-Cl ₂ H CH ₃ Ph-2,4,6-F ₃ C (O) Pr-c * 1
7-036 3,4,5-Cl ₃ Cl H CH ₃ C (O) (E-6a) * 1
7-037 3,5-Cl ₂ Cl H -CH ₂ CH ₂ CH ₂ C (O)-* 1
7-038 3,5-Cl ₂ Cl H -CH ₂ CH ₂ CH ₂ CH ₂ C (O)-* 1
7-039 3,5-Cl ₂ Cl H -CH ₂ CH ₂ CH ₂ CH ₂ CH ₂ C (O)-* 1
7-040 3,4,5-Cl ₃ Cl H CH ₃ C (O) (Ph-2,4,6-F ₃ ) 209.0-211.0
7-041 3,5-Cl ₂ H CH ₃ CH ₃ C (O) (Ph-2,4,6-F ₃ ) * 1
7-042 3,4,5-Cl ₃ Cl H Et C (O) (Ph-2,4,6-F ₃ ) * 1
7-043 3,4,5-Cl ₃ Cl H CH ₂ OCH ₃ C (O) (Ph-2,4,6-F ₃ ) 169.0-172.0
7-044 3,5-Cl ₂ Cl H -CH ₂ CH ₂ OC (O)-* 1
7-045 3,4,5-Cl ₃ Cl H -C (= CH ₂ ) CH ₂ OC (O)-* 1
7-046 3,5-Cl ₂ Cl H CH ₂ CH ₂ SCH ₃ C (O) NHEt * 1
7-047 3,4,5-Cl ₃ Cl H -C (O) CH ₂ NHC (O)-* 1
7-048 3,5- (CF ₃ ) ₂ Cl H CH ₃ C (O) CH ₂ Pr-c * 1
7-049 3,5- (CF ₃ ) ₂ Cl H Et C (O) CH ₂ Pr-c * 1
7-050 3,5- (CF ₃ ) ₂ Cl H n-Pr C (O) CH ₂ Pr-c * 1
7-051 3,5- (CF ₃ ) ₂ Cl H CH ₂ Pr-c C (O) CH ₂ Pr-c * 1
7-052 3,5- (CF ₃ ) ₂ Cl H CH ₂ C≡CH C (O) CH ₂ Pr-c * 1
7-053 3,5- (CF ₃ ) ₂ Cl H CH ₃ C (O) (D-24a) * 1
7-054 3,5- (CF ₃ ) ₂ Cl H CH ₃ C (O) NHEt 172.0-174.0
7-055 3,5- (CF ₃ ) ₂ Cl H Et C (O) NHEt 180.0-182.0
7-056 3,5- (CF ₃ ) ₂ Cl H n-Pr C (O) NHEt 133.0-135.0
7-057 3,5- (CF ₃ ) ₂ Cl H CH ₂ Pr-c C (O) NHEt 147.0-150.0
7-058 3,5- (CF ₃ ) ₂ Cl H CH ₂ C≡CH C (O) NHEt 150.0-153.0
7-059 3-Br-5-CF ₃ Br H Et C (O) CH ₃ 120.0-122.0
7-060 3,5- (CF ₃ ) ₂ Cl H CH ₂ C (O) NH ₂ C (O) CH ₃ * 1
7-061 3,5- (CF ₃ ) ₂ Cl H CH ₂ C (O) NHCH ₃ C (O) CH ₃ * 1
7-062 3,5- (CF ₃ ) ₂ Cl H Et C (O) Et * 1
7-063 3,4-Cl ₂ -5-CF ₃ Cl H Et C (O) Et * 1
7-064 3-Br-5-CF ₃ Br H Et C (O) Et 69.0-71.0
7-065 3,5- (CF ₃ ) ₂ Cl H n-Pr C (O) Et * 1
7-066 3,5- (CF ₃ ) ₂ Cl H CH ₂ CN C (O) Et * 1
7-067 3,4-Cl ₂ -5-CF ₃ Cl H CH ₂ CN C (O) Et * 1
7-068 3,5- (CF ₃ ) ₂ Cl H CH ₂ C (O) NH ₂ C (O) Et * 1
7-069 3,5- (CF ₃ ) ₂ Cl H CH ₂ C (O) NHCH ₃ C (O) Et * 1
7-070 3,5- (CF ₃ ) ₂ Cl H CH ₂ CH = CH ₂ C (O) Et * 1
7-071 3,4-Cl ₂ -5-CF ₃ Cl H CH ₂ CH = CH ₂ C (O) Et * 1
7-072 3,5- (CF ₃ ) ₂ Cl H CH ₂ C≡CH C (O) Et * 1
7-073 3,5- (CF ₃ ) ₂ Cl H Et C (O) Pr-n * 1
7-074 3,4-Cl ₂ -5-CF ₃ Cl H Et C (O) Pr-n * 1
7-075 3,5- (CF ₃ ) ₂ Cl H n-Pr C (O) Pr-n * 1
7-076 3,5- (CF ₃ ) ₂ Cl H CH ₂ CN C (O) Pr-n * 1
7-077 3,4-Cl ₂ -5-CF ₃ Cl H CH ₂ CN C (O) Pr-n * 1
7-078 3,5- (CF ₃ ) ₂ Cl H CH ₂ C (O) NH ₂ C (O) Pr-n * 1
7-079 3,5- (CF ₃ ) ₂ Cl H CH ₂ C (O) NHCH ₃ C (O) Pr-n * 1
7-080 3,4-Cl ₂ -5-CF ₃ Cl H CH ₂ CH = CH ₂ C (O) Pr-n * 1
7-081 3,5- (CF ₃ ) ₂ Cl H CH ₂ C≡CH C (O) Pr-n * 1
7-082 3-Br-5-CF ₃ Br H Et C (O) Pr-i 68.0-70.0
7-083 3,4-Cl ₂ -5-CF ₃ Cl H CH ₃ C (O) Pr-c * 1
7-084 3,4-Cl ₂ -5-CF ₃ Br H CH ₃ C (O) Pr-c * 1
7-085 3,4-Cl ₂ -5-CF ₃ H CH ₃ CH ₃ C (O) Pr-c * 1
7-086 3,5- (CF ₃ ) ₂ Cl H Et C (O) Pr-c * 1
7-087 3,4-Cl ₂ -5-CF ₃ Cl H Et C (O) Pr-c * 1
7-088 3-Br-5-CF ₃ Br H Et C (O) Pr-c 61.0-62.0
7-089 3,4-Cl ₂ -5-CF ₃ Br H Et C (O) Pr-c * 1
7-090 3,4-Cl ₂ -5-CF ₃ H CH ₃ Et C (O) Pr-c * 1
7-091 3,5- (CF ₃ ) ₂ Cl H n-Pr C (O) Pr-c * 1
7-092 3,4-Cl ₂ -5-CF ₃ Cl H n-Pr C (O) Pr-c * 1
7-093 3,4-Cl ₂ -5-CF ₃ Br H n-Pr C (O) Pr-c * 1
7-094 3,4-Cl ₂ -5-CF ₃ H CH ₃ n-Pr C (O) Pr-c * 1
7-095 3-Br-5-CF ₃ Br H CH ₂ CH ₂ SCH ₃ C (O) Pr-c 49.0-51.0
7-096 3-Br-5-CF ₃ Br H CH ₂ CH ₂ S (O) CH ₃ C (O) Pr-c * 1
7-097 3-Br-5-CF ₃ Br H CH ₂ CH ₂ SO ₂ CH ₃ C (O) Pr-c * 1
7-098 3-Br-5-CF ₃ Br H CH ₂ CH ₂ NHC (O) CH ₃ C (O) Pr-c * 1
7-099 3,5-Cl ₂ Cl H CH ₂ CH ₂ NHC (O) OBu-t C (O) Pr-c * 1
7-100 3,5-Cl ₂ Cl H CH ₂ CH ₂ NHC (O) NHEt C (O) Pr-c * 1
7-101 3,5- (CF ₃ ) ₂ Cl H CH ₂ CN C (O) Pr-c * 1
7-102 3,4-Cl ₂ -5-CF ₃ Cl H CH ₂ CN C (O) Pr-c * 1
7-103 3,4-Cl ₂ -5-CF ₃ Br H CH ₂ CN C (O) Pr-c * 1
7-104 3,4-Cl ₂ -5-CF ₃ H CH ₃ CH ₂ CN C (O) Pr-c * 1
7-105 3,5- (CF ₃ ) ₂ Cl H CH ₂ C (O) NH ₂ C (O) Pr-c * 1
7-106 3,5- (CF ₃ ) ₂ Cl H CH ₂ C (O) NHCH ₃ C (O) Pr-c 134.0-135.0
7-107 3,4-Cl ₂ -5-CF ₃ Cl H CH ₂ C (S) NH ₂ C (O) Pr-c * 1
7-108 3,5- (CF ₃ ) ₂ Cl H CH ₂ CH = CH ₂ C (O) Pr-c * 1
7-109 3,4-Cl ₂ -5-CF ₃ Cl H CH ₂ CH = CH ₂ C (O) Pr-c * 1
7-110 3,4-Cl ₂ -5-CF ₃ Br H CH ₂ CH = CH ₂ C (O) Pr-c * 1
7-111 3,4-Cl ₂ -5-CF ₃ H CH ₃ CH ₂ CH = CH ₂ C (O) Pr-c * 1
7-112 3,5- (CF ₃ ) ₂ Cl H CH ₂ C≡CH C (O) Pr-c * 1
7-113 3,4-Cl ₂ -5-CF ₃ Cl H CH ₂ C≡CH C (O) Pr-c * 1
7-114 3,4-Cl ₂ -5-CF ₃ Br H CH ₂ C≡CH C (O) Pr-c * 1
7-115 3,4-Cl ₂ -5-CF ₃ H CH ₃ CH ₂ C≡CH C (O) Pr-c * 1
7-116 3,5- (CF ₃ ) ₂ Cl H Et C (O) Bu-i * 1
7-117 3,5- (CF ₃ ) ₂ Cl H n-Pr C (O) Bu-i * 1
7-118 3,5- (CF ₃ ) ₂ Cl H CH ₂ CN C (O) Bu-i * 1
7-119 3,5- (CF ₃ ) ₂ Cl H CH ₂ C≡CH C (O) Bu-i * 1
7-120 3,5- (CF ₃ ) ₂ Cl H i-Bu C (O) CH ₂ Pr-c 144.0-146.0
7-121 3,5- (CF ₃ ) ₂ Cl H CH ₂ CH = CH ₂ C (O) CH ₂ Pr-c * 1
7-122 3,5- (CF ₃ ) ₂ Cl H CH ₂ Ph C (O) CH ₂ Pr-c * 1
7-123 3,5- (CF ₃ ) ₂ Cl H i-Bu C (O) NHEt 145.0-147.0
7-124 3,5- (CF ₃ ) ₂ Cl H CH ₂ CN C (O) NHEt * 1
7-125 3,5- (CF ₃ ) ₂ Cl H CH ₂ CH = CH ₂ C (O) NHEt * 1
7-126 3,5- (CF ₃ ) ₂ Cl H CH ₂ Ph C (O) NHEt 162.0-164.0
7-127 3,5- (CF ₃ ) ₂ Cl H CH ₂ Pr-c C (O) C (O) NHPr-c * 1
7-128 3,5- (CF ₃ ) ₂ Br H CH ₃ SO ₂ (Ph-2,4-F ₂ ) 142.0-144.0
―――――――――――――――――――――――――――――――――――――――
Table 12

  The bonding part L in the above general formula is any of the following L-6, L-7, L-8, L-9, L-10, L-13, L-16, L-22 or L-25, respectively. The structure shown by is represented.

―――――――――――――――――――――――――――――――――――――――
No. (X) _m A ¹ LR ² R ^1a mp (℃)
―――――――――――――――――――――――――――――――――――――――
8-001 3,5-Cl ₂ CH L-9 H c-Pr 140.0-143.0
8-002 3,5-Cl ₂ CNO ₂ L-9 H c-Pr 128.0-131.0
8-003 3,5-Cl ₂ CNO ₂ L-25 H c-Pr * 1
8-004 3,5-Cl ₂ N L-10 H c-Pr * 1
8-005 3,5-Cl ₂ CH L-13 H CH ₂ CF ₃ * 1
8-006 3,5-Cl ₂ CCl L-16 H i-Pr * 1
8-007 3,5-Cl ₂ CCl L-22 H i-Pr * 1
8-008 3,5-Cl ₂ CH L-6 H CH ₃ 166.0-168.0
8-009 3,5-Cl ₂ CH L-7 C (O) Pr-i i-Pr * 1
8-010 3,5-Cl ₂ CH L-7 H c-Pr * 1
8-011 3,5-Cl ₂ CH L-6 H Et 157.0-159.0
8-012 3,5-Cl ₂ CH L-6 H n-Pr 81.0-85.0
8-013 3,5-Cl ₂ CH L-6 H c-Pr 135.0-139.0
8-014 3,5-Cl ₂ CH L-7 H i-Pr * 1
8-015 3,5-Cl ₂ CH L-7 H CH ₂ Pr-c * 1
8-016 3,5-Cl ₂ CH L-7 H CH ₂ SCH ₃ * 1
8-017 3,5-Cl ₂ CH L-7 H Ph-2,4-F ₂ * 1
8-018 3,5-Cl ₂ CH L-7 H Ph-2,4,6-F ₃ * 1
8-019 3,5-Cl ₂ CH L-7 H D-58a 122.0-125.0
8-020 3,4,5-Cl ₃ CH L-8 H c-Pr * 1
―――――――――――――――――――――――――――――――――――――――
Table 13

  The bonding portion L in the above general formula represents a structure represented by any of the following L-1, L-2, L-4, L-9, L-26 or L-27.

―――――――――――――――――――――――――――――――――――――――
No. (X) _m A ¹ A ² LR ² mp (℃)
―――――――――――――――――――――――――――――――――――――――
9-001 3,5-Cl ₂ CH CH L-1 H * 1
9-002 3,5-Cl ₂ CH CH L-1 CH ₃ * 1
9-003 3,5-Cl ₂ CH CH L-1 Et * 1
9-004 3,5-Cl ₂ CH CH L-1 i-Pr * 1
9-005 3,5-Cl ₂ CH CH L-1 CH ₂ (D-52a) * 2
9-006 3,5-Cl ₂ CH CH L-1 Ph-4-F * 1
9-007 3,5-Cl ₂ CH CH L-2 H * 1
9-008 3,5-Cl ₂ CH CH L-2 M-11a * 1
9-009 3,5-Cl ₂ CH CH L-26 H * 1
9-010 3,5-Cl ₂ CF CH L-1 H * 2
9-011 3,5-Cl ₂ CCl CH L-1 H * 1
9-012 3,5-Cl ₂ CCl CH L-1 Et * 1
9-013 3,5-Cl ₂ CCl CH L-1 CH ₂ C (O) NHCH ₂ CF ₃ * 1
9-014 3,5-Cl ₂ CCl CH L-1 OCH ₃ * 1
9-015 3,5-Cl ₂ CCl CH L-1 OEt * 1
9-016 3,5-Cl ₂ CCl CH L-2 H * 1
9-017 3,5-Cl ₂ CCl CH L-4 H * 1
9-018 3,5-Cl ₂ CBr CH L-1 H * 1
9-019 3,5-Cl ₂ CI CH L-1 H 125.0-127.0
9-020 3,5-Cl ₂ CCH ₃ CH L-1 H * 1
9-021 3,5-Cl ₂ CNO ₂ CH L-1 H * 1
9-022 3,4,5-Cl ₃ CCl CH L-1 H * 1
9-023 3,5-Cl ₂ CCl CH L-1 CH ₃ * 1
9-024 3,5-Cl ₂ CCl CH L-1 c-Pr * 1
9-025 3,5-Cl ₂ CCl CH L-1 CH ₂ Pr-c * 1
9-026 3,5-Cl ₂ CCl CH L-1 CH ₂ CF ₃ 101.0-103.0
9-027 3,5-Cl ₂ CCl CH L-1 CH ₂ CH ₂ OCH ₃ * 1
9-028 3,5-Cl ₂ CNO ₂ CH L-9 H 202.0-205.0
9-029 3,5-Cl ₂ CCl CH L-1 (D-52d) Cl * 1
9-030 3,5-Cl ₂ CI CH L-1 Et * 1
9-031 3,4,5-Cl ₃ CH CH L-1 H 113.0-117.0
9-032 3,5- (CF ₃ ) ₂ CCl CH L-1 H * 1
9-033 3,4,5-Cl ₃ CBr CH L-1 H * 1
9-034 3,4,5-Cl ₃ CNO ₂ CH L-1 H * 1
9-035 3,5-Cl ₂ CCH = CHCH = CHC L-1 H * 1
9-036 3,4,5-Cl ₃ CCl CH L-1 CH ₃ * 1
9-037 3,4,5-Cl ₃ CCl CH L-1 Et * 1
9-038 3,4,5-Cl ₃ CCl CH L-1 n-Pr * 1
9-039 3,4,5-Cl ₃ CCl CH L-1 n-Bu * 1
9-040 3,4,5-Cl ₃ CCl CH L-1 CH ₂ Pr-c * 1
9-041 3,5-Cl ₂ CCl CH L-1 CH ₂ CH ₂ SCH ₃ * 1
9-042 3,4,5-Cl ₃ CCl CH L-1 CH ₂ C≡CH * 1
9-043 3,5-Cl ₂ CCl CH L-1 CH ₂ (Ph-4-F) * 1
9-044 3,4,5-Cl ₃ CCl CH L-1 CN * 1
9-045 3,4,5-Cl ₃ CCl CH L-1 N (CH ₃ ) ₂ * 1
9-046 3,4,5-Cl ₃ CH CH L-2 H 57.0-61.0
9-047 3,5-Cl ₂ CH CH L-2 Et * 1
9-048 3,4,5-Cl ₃ CH CH L-4 H * 1
9-049 3-CF ₃ -4-Cl CCl CH L-1 H * 1
9-050 3,5-Cl ₂ -4-OCHF ₂ CCl CH L-1 H * 1
9-051 3,5- (CF ₃ ) ₂ CCl CH L-1 CH ₃ * 1
9-052 3,5- (CF ₃ ) ₂ CCl CH L-1 Et * 1
9-053 3,5- (CF ₃ ) ₂ CCl CH L-1 n-Pr * 1
9-054 3,5- (CF ₃ ) ₂ CCl CH L-1 CH ₂ Pr-c * 1
9-055 3,5- (CF ₃ ) ₂ CCl CH L-1 CH ₂ C≡CH * 1
9-056 3,4-Cl ₂ -5-CF ₃ CCl CH L-1 Et * 1
9-057 3,4-Cl ₂ -5-CF ₃ CCl CH L-1 n-Pr * 1
9-058 3,5- (CF ₃ ) ₂ CCl CH L-1 i-Bu * 1
9-059 3,5-Cl ₂ CCl CH L-1 CH ₂ CH ₂ NHC (O) CH ₃ * 1
9-060 3-Br-5-CF ₃ CBr CH L-1 CH ₂ CH ₂ NHC (O) CH ₃ * 1
9-061 3,5-Cl ₂ CCl CH L-1 CH ₂ CH ₂ NHC (O) OBu-t * 1
9-062 3,5- (CF ₃ ) ₂ CCl CH L-1 CH ₂ CN * 1
9-063 3,4-Cl ₂ -5-CF ₃ CCl CH L-1 CH ₂ CN * 1
9-064 3,5- (CF ₃ ) ₂ CCl CH L-1 CH ₂ C (O) OCH ₃ * 1
9-065 3,5- (CF ₃ ) ₂ CCl CH L-1 CH ₂ CH = CH ₂ * 1
9-066 3,4-Cl ₂ -5-CF ₃ CCl CH L-1 CH ₂ CH = CH ₂ * 1
9-067 3,4-Cl ₂ -5-CF ₃ CCl CH L-1 CH ₂ C≡CH * 1
9-068 3,5- (CF ₃ ) ₂ CCl CH L-1 CH ₂ Ph 109.0-111.0
9-069 3,5- (CF ₃ ) ₂ CCl CH L-4 H * 1
9-070 3,5-Cl ₂ CCH ₃ CH L-4 H * 1
9-071 3,5-Cl ₂ CH CH L-27 H * 1
―――――――――――――――――――――――――――――――――――――――
Table 14

―――――――――――――――――――――――――――――――――――――――
No. (X) _m YA ⁴ R ⁴ R ² mp (℃)
―――――――――――――――――――――――――――――――――――――――
10-001 3,5-Cl ₂ Cl NHH * 1
―――――――――――――――――――――――――――――――――――――――
Table 15

―――――――――――――――――――――――――――――――――――――――
No. (X) _m A ¹ A ² A ^Four R ^Four mp (℃)
―――――――――――――――――――――――――――――――――――――――
11-001 3,5-Cl ₂ CH CH CH H 190.0-192.0
11-002 3,5-Cl ₂ CH CH CH CH _Three * 1
11-003 3,5-Cl ₂ CH CH CH Et * 1
11-004 3,5-Cl ₂ CF CH CH H * 1
11-005 3,5-Cl ₂ CCl CH CH H * 1
11-006 3,5-Cl ₂ CCl CH CH CH _Three * 1
11-007 3,5-Cl ₂ CBr CH CH H * 1
11-008 3,5-Cl ₂ CI CH CH H 59.0-61.0
11-009 3,5-Cl ₂ CCH _Three CH CH H * 1
11-010 3,5-Cl ₂ CNO ₂ CH CH H 115.0-118.0
11-011 3,4,5-Cl _Three CCl CH CH H * 1
11-012 3,4,5-Cl _Three CH CH CH H 164.0-167.0
11-013 3,5- (CF _Three ) ₂ CCl CH CH H * 1
11-014 3,4,5-Cl _Three CNO ₂ CH CH H 91.0-94.0
11-015 3,5-Cl ₂ CCN CH CH H * 1
11-016 3,5-Cl ₂ CCH = CHCH = CHC CH H 238.0-239.0
11-017 3,5- (CF _Three ) ₂ CH CH CH CH _Three * 1
11-018 3,4,5-Cl _Three CH CH CH CH _Three * 1
11-019 3-CF _Three -4-Cl CCl CH CH H * 1
11-020 3,5-Cl ₂ -4-OCHF ₂ CCl CH CH H * 1
11-021 3,4-Cl ₂ -5-CF _Three CCl CH CH H * 1
―――――――――――――――――――――――――――――――――――――――
Of the compounds of the present invention, the measured value of molecular ion peak, melting point or refractive index ¹ 1 H NMR data is shown in Table 16.
Table 16
―――――――――――――――――――――――――――――――――――――――
No. ¹ H NMR (CDCl _Three , Me _Four (Si, 300MHz)
―――――――――――――――――――――――――――――――――――――――
2-005 δ7.63 (d, J = 8.1Hz, 2H), 7.51 (d, J = 1.5Hz, 2H), 7.42 (t, J = 1.5Hz, 1H),
7.33 (d, J = 8.1Hz, 2H), 6.12 (bs, 1H), 4.52 (d, J = 6.0Hz, 2H),
4.07 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H), 3.13 (q, J = 10.8Hz, 2H).
2-010 δ8.52 (d, J = 4.7Hz, 1H), 7.96 (bs, 1H), 7.65-7.8 (m, 1H),
7.58 (d, J = 8.2Hz, 2H), 7.50 (s, 2H), 7.41 (s, 1H), 7.15-7.35 (m, 4H),
4.49 (d, J = 6.0Hz, 2H), 4.09 (d, J = 17.4Hz, 1H), 3.80 (s, 2H),
3.69 (d, J = 17.4Hz, 1H).
2-014 δ8.14 (d, J = 3.9Hz, 1H), 7.76 (bs, 1H), 7.63 (d, J = 8.2Hz, 2H),
7.50 (d, J = 1.5Hz, 1H), 7.35-7.5 (m, 3H), 6.36 (d, J = 3.9Hz, 1H),
4.65 (d, J = 6.0Hz, 2H), 4.09 (d, J = 17.4Hz, 1H), 3.91 (s, 3H),
3.68 (d, J = 17.4Hz, 1H).
2-021 δ7.64 (d, J = 8.1Hz, 2H), 7.51 (d, J = 1.5Hz, 2H), 7.42 (t, J = 1.5Hz, 1H),
7.36 (d, J = 8.1Hz, 2H), 5.97 (d, J = 7.2Hz, 1H), 5.1-5.25 (m, 1H),
4.07 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H), 3.08 (q, J = 10.8Hz, 2H),
1.52 (d, J = 6.6Hz, 3H).
2-025 δ7.64 (d, J = 8.1Hz, 2H), 7.51 (d, J = 1.5Hz, 2H), 7.42 (t, J = 1.5Hz, 1H),
7.32 (d, J = 8.1Hz, 2H), 6.05 (d, J = 7.5Hz, 1H), 4.89 (d, J = 7.5Hz, 1H),
4.07 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 3.08 (q, J = 10.8Hz, 2H),
1.75-1.95 (m, 2H), 0.91 (t, J = 7.2Hz, 3H).
2-029 δ7.3-7.55 (m, 6H), 6.17 (bs, 1H), 4.55 (d, J = 6.0Hz, 2H),
4.08 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 3.11 (q, J = 10.8Hz, 2H).
2-033 δ7.69 (s, 1H), 7.45-7.6 (m, 3H), 7.4-7.5 (m, 2H), 7.1-7.3 (m, 1H),
4.55 (d, J = 6.0Hz, 2H), 4.35-4.5 (m, 1H), 4.07 (d, J = 17.4Hz, 1H),
3.8-4.0 (m, 2H), 3.69 (d, J = 17.4Hz, 1H), 2.2-2.4 (m, 1H),
2.0-2.15 (m, 1H), 1.8-2.0 (m, 2H).
2-035 δ7.72 (d, J = 1.5Hz, 1H), 7.54 (dd, J = 8.1, 1.5Hz, 1H), 7.49 (s, 2H),
7.45 (d, J = 8.1Hz, 1H), 7.43 (t, J = 1.5Hz, 1H), 6.58 (bs, 1H),
4.59 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
3.41 (s, 2H).
2-036 δ7.72 (s, 1H), 7.35-7.55 (m, 8H), 7.15-7.25 (m, 1H), 6.63 (bs, 1H),
4.74 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H).
2-037 δ7.75-7.85 (m, 2H), 7.71 (s, 1H), 7.45-7.55 (m, 4H),
7.43 (t, J = 1.5Hz, 1H), 7.05-7.15 (m, 2H), 6.63 (t, J = 6.0Hz, 1H),
4.72 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H).
2-038 δ7.69 (s, 1H), 7.4-7.55 (m, 5H), 7.25-7.35 (m, 2H), 6.9-7.0 (m, 1H),
6.89 (t, J = 6.0Hz, 1H), 4.69 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.69 (d, J = 17.4Hz, 1H).
2-045 δ7.89 (s, 1H), 7.58 (dd, J = 8.1, 1.5Hz, 1H), 7.50 (s, 2H),
7.4-7.5 (m, 2H), 6.25 (bs, 1H), 4.57 (d, J = 6.0Hz, 2H),
4.09 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 3.12 (q, J = 10.8Hz, 2H).
2-046 δ8.11 (s, 1H), 7.61 (dd, J = 8.1, 1.5Hz, 1H), 7.50 (s, 2H),
7.35-7.5 (m, 2H), 5.94 (bs, 1H), 4.47 (d, J = 6.0Hz, 2H),
4.04 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H), 2.26 (d, J = 7.7Hz, 2H),
1.18 (t, J = 7.7Hz, 3H).
2-055 δ8.51 (d, J = 3.9Hz, 1H), 7.89 (bs, 1H), 7.7-7.8 (m, 1H),
7.35-7.55 (m, 5H), 7.32 (d, J = 7.8Hz, 1H), 7.15-7.3 (m, 2H),
4.46 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.82 (s, 2H),
3.67 (d, J = 17.4Hz, 1H), 2.30 (s, 3H).
2-056 δ7.49 (d, J = 1.5Hz, 2H), 7.42 (t, J = 1.5Hz, 1H), 7.09 (d, J = 8.1Hz, 1H),
6.98 (s, 1H), 6.91 (d, J = 8.1Hz, 1H), 6.10 (bs, 1H),
4.42 (d, J = 6.0Hz, 2H), 4.34 (bs, 2H), 4.09 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 3.09 (d, J = 10.8Hz, 2H).
2-057 δ8.32 (d, J = 1.5Hz, 1H), 7.95 (dd, J = 8.1, 1.5Hz, 1H),
7.75 (d, J = 8.1Hz, 1H), 7.50 (d, J = 1.5Hz, 2H), 7.44 (t, J = 1.5Hz, 1H),
6.63 (t, J = 7.8Hz, 1H), 4.74 (d, J = 6.0Hz, 2H), 4.09 (d, J = 17.4Hz, 1H),
3.72 (d, J = 17.4Hz, 1H), 3.09 (q, J = 10.8Hz, 2H).
2-058 δ7.70 (dd, J = 8.1, 1.5Hz, 1H), 7.45-7.55 (m, 4H), 7.4-7.45 (m, 2H),
7.1-7.25 (m, 3H), 5.63 (bs, 1H), 4.36 (bs, 2H), 4.08 (d, J = 17.4Hz, 1H),
3.69 (d, J = 17.4Hz, 1H), 2.17 (q, J = 7.7Hz, 2H), 1.11 (t, J = 7.7Hz, 3H).
2-059 δ7.69 (d, J = 1.5Hz, 1H), 7.64 (s, 2H), 7.45-7.55 (m, 2H), 6.10 (bs, 1H),
4.56 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H),
1.3-1.45 (m, 1H), 0.95-1.0 (m, 2H), 0.7-0.8 (m, 2H).
2-061 δ7.69 (d, J = 1.5Hz, 1H), 7.45-7.55 (m, 3H), 7.46 (d, J = 8.1Hz, 1H),
7.42 (t, J = 1.5Hz, 1H), 6.44 (bs, 1H), 4.56 (d, J = 6.6Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 2.20 (d, J = 7.2Hz, 2H),
0.9-1.05 (m, 1H), 0.6-0.7 (m, 2H), 0.15-0.25 (m, 2H).
2-062 δ7.69 (d, J = 1.5Hz, 1H), 7.45-7.55 (m, 4H), 7.42 (t, J = 1.5Hz, 1H),
6.00 (bs, 1H), 4.55 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 2.75-2.95 (m, 1H),
2.59 (dd, J = 15.0, 4.8Hz, 1H), 2.14 (dd, J = 15.0, 9.3Hz, 1H),
1.13 (d, J = 7.2Hz, 3H).
2-063 δ7.70 (d, J = 1.5Hz, 1H), 7.45-7.55 (m, 3H), 7.40-7.45 (m, 2H),
6.08 (bs, 1H), 4.57 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.8-3.95 (m, 1H), 3.66 (d, J = 17.4Hz, 1H), 2.64 (d, J = 6.0Hz, 2H).
2-064 δ7.67 (d, J = 1.5Hz, 1H), 7.45-7.55 (m, 3H), 7.45 (d, J = 8.1Hz, 1H),
7.42 (t, J = 1.5Hz, 1H), 5.87 (bs, 1H), 4.51 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 1.24 (s, 6H),
1.16 (s, 6H), 0.88 (s, 1H).
2-065 δ7.70 (d, J = 1.5Hz, 1H), 7.45-7.5 (m, 4H), 7.42 (t, J = 1.5Hz, 1H),
6.20 (bs, 1H), 4.60 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 2.23 (d, J = 7.8Hz, 1H), 1.60 (s, 3H),
1.69 (d, J = 7.8Hz, 1H).
2-066 δ7.68 (d, J = 1.5Hz, 1H), 7.52 (dd, J = 8.1, 1.5Hz, 1H),
7.49 (d, J = 1.5Hz, 2H), 7.44 (d, J = 8.1Hz, 1H), 7.42 (t, J = 1.5Hz, 1H),
7.00 (t, J = 6.0Hz, 1H), 4.58 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.94 (s, 2H), 3.67 (d, J = 17.4Hz, 1H), 3.42 (s, 3H).
2-067 δ7.68 (d, J = 1.5Hz, 1H), 7.45-7.5 (m, 3H), 7.4-7.45 (m, 2H),
6.95-7.1 (m, 3H), 6.8-6.9 (m, 2H), 4.64 (d, J = 6.0Hz, 2H),
4.50 (s, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H).
2-068 δ7.68 (s, 1H), 7.45-7.55 (m, 3H), 7.45 (d, J = 8.1Hz, 1H),
7.42 (t, J = 1.5Hz, 1H), 6.80 (bs, 1H), 4.54 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 3.64 (t, J = 5.7Hz, 2H),
3.38 (s, 3H), 2.51 (t, J = 5.7Hz, 2H).
2-070 δ7.70 (d, J = 1.5Hz, 1H), 7.54 (dd, J = 8.1, 1.5Hz, 1H), 7.45-7.5 (m, 3H),
7.42 (t, J = 1.5Hz, 1H), 6.84 (bs, 1H), 4.60 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.91 (s, 2H), 3.66 (d, J = 17.4Hz, 1H),
3.04 (s, 3H).
2-071 δ7.75-7.8 (m, 2H), 7.67 (d, J = 1.5Hz, 1H), 7.4-7.55 (m, 8H),
6.92 (s, 1H), 6.79 (bs, 1H), 4.57 (d, J = 6.0Hz, 2H),
4.17 (d, J = 6.0Hz, 2H), 4.03 (d, J = 17.4Hz, 1H), 3.64 (d, J = 17.4Hz, 1H).
2-072 δ7.70 (d, J = 1.5Hz, 1H), 7.54 (dd, J = 8.1, 1.5Hz, 1H),
7.49 (t, J = 1.5Hz, 2H), 7.4-7.45 (m, 2H), 6.88 (t, J = 6.0Hz, 1H),
4.59 (d, J = 9.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
1.65-1.75 (m, 2H), 1.5-1.6 (m, 2H).
2-073 δ7.69 (s, 1H), 7.45-7.55 (m, 4H), 7.42 (t, J = 1.5Hz, 1H), 6.11 (bs, 1H),
4.56 (d, J = 6.6Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H),
2.5-2.6 (m, 2H), 2.4-2.5 (m, 2H), 2.00 (t, J = 2.4Hz, 1H).
2-075 δ7.62 (d, J = 1.5Hz, 1H), 7.45-7.5 (m, 3H), 7.3-7.45 (m, 7H),
5.84 (bs, 1H), 4.42 (d, J = 6.0Hz, 2H), 4.03 (d, J = 17.4Hz, 1H),
3.64 (d, J = 17.4Hz, 1H), 1.55-1.65 (m, 2H), 1.05-1.15 (m, 2H).
2-076 δ7.65-7.75 (m, 3H), 7.45-7.55 (m, 4H), 7.35-7.45 (m, 3H), 6.59 (bs, 1H),
4.72 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H).
2-077 δ7.88 (d, J = 8.4Hz, 2H), 7.7-7.75 (m, 3H), 7.45-7.6 (m, 4H),
7.42 (t, J = 1.5Hz, 1H), 6.66 (bs, 1H), 4.75 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H).
2-083 δ7.72 (d, J = 8.7Hz, 2H), 7.45-7.6 (m, 4H), 7.42 (t, J = 1.5Hz, 1H),
6.24 (d, J = 8.7Hz, 1H), 6.05 (d, J = 8.7Hz, 1H), 4.07 (d, J = 17.4Hz, 1H),
3.69 (d, J = 17.4Hz, 1H), 2.35-2.5 (m, 1H),
1.21 and 1.18 (d, J = 6.9Hz, 6H).
2-086 δ7.76 (d, J = 3.6Hz, 1H), 7.63 (d, J = 8.1Hz, 2H), 7.49 (d, J = 1.5Hz, 2H),
7.45 (d, J = 8.1Hz, 2H), 7.41 (t, J = 1.5Hz, 1H), 7.32 (d, J = 3.6Hz, 1H),
7.20 (d, J = 6.6Hz, 1H), 6.43 (d, J = 6.6Hz, 1H), 4.04 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 1.45-1.55 (m, 1H), 0.9-1.05 (m, 2H),
0.75-0.85 (m, 2H).
2-087 δ7.69 (s, 1H), 7.45-7.55 (m, 4H), 7.42 (t, J = 1.5Hz, 1H), 6.02 (bs, 1H),
4.54 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H),
1.3-1.4 (m, 1H), 1.1-1.2 (m, 2H), 1.09 (d, J = 6.0Hz, 3H),
0.55-0.65 (m, 1H).
2-091 δ7.68 (d, J = 1.5Hz, 1H), 7.4-7.55 (m, 5H), 6.68 (bs, 1H), 5.08 (bs, 1H),
4.56 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.81 (d, J = 6.0Hz, 2H),
3.66 (d, J = 17.4Hz, 1H), 1.44 (s, 9H).
2-092 δ7.70 (d, J = 1.5Hz, 1H), 7.53 (dd, J = 8.1, 1.5Hz, 1H),
7.50 (d, J = 1.5Hz, 2H), 7.45 (d, J = 8.1Hz, 1H), 7.4-7.45 (m, 2H),
6.96 (bs, 1H), 4.62 (d, J = 6.6Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.98 (s, 3H), 3.66 (d, J = 17.4Hz, 1H).
2-093 δ7.87 (d, J = 6.9Hz, 2H), 7.7-7.75 (m, 3H), 7.45-7.55 (m, 4H),
7.42 (t, J = 1.5Hz, 1H), 6.65 (t, J = 6.0Hz, 1H), 4.75 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H).
2-098 δ8.05-8.2 (m, 1H), 7.87 (s, 1H), 7.15-7.65 (m, 6H), 6.8-7.05 (m, 2H),
7.43 (d, J = 5.7Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H).
2-100 δ8.29 (d, J = 1.5Hz, 1H), 7.92 (dd, J = 8.1, 1.5Hz, 1H),
7.75 (d, J = 1.5Hz, 1H), 7.50 (d, J = 1.5Hz, 2H), 7.44 (t, J = 1.5Hz, 1H),
6.45 (t, J = 6.3Hz, 1H), 4.71 (d, J = 6.3Hz, 2H), 4.11 (d, J = 17.4Hz, 1H),
3.71 (d, J = 17.4Hz, 1H), 1.3-1.45 (m, 1H), 0.9-1.0 (m, 2H),
0.7-0.8 (m, 2H).
2-102 δ7.50 (s, 2H), 7.4-7.45 (m, 1H), 7.32 (d, J = 7.5Hz, 1H),
7.24 (dd, J = 7.5, 1.5Hz, 1H), 7.08 (d, J = 1.5Hz, 1H), 6.37 (bs, 1H),
4.37 (d, J = 5.7Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.81 (s, 3H),
3.67 (d, J = 17.4Hz, 1H), 3.08 (q, J = 10.5Hz, 2H), 1.87 (s, 3H).
2-103 δ8.26 (s, 1H), 7.35-7.7 (m, 5H), 6.50 (t, J = 6.3Hz, 1H),
4.55 (d, J = 6.3Hz, 2H), 4.07 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H).
2-104 δ8.07 (s, 2H), 7.96 (s, 1H), 7.69 (d, J = 1.5Hz, 1H),
7.52 (dd, J = 7.8, 1.5Hz, 1H), 7.45 (d, J = 7.8Hz, 1H),
5.99 (t, J = 6.0Hz, 1H), 4.53 (d, J = 6.3Hz, 2H), 4.16 (d, J = 17.4Hz, 1H),
3.71 (d, J = 17.4Hz, 1H), 2.26 (q, J = 7.5Hz, 2H), 1.17 (t, J = 7.6Hz, 3H).
2-105 δ7.68 (d, J = 1.5Hz, 1H), 7.63 (s, 2H), 7.49 (dd, J = 7.8, 1.5Hz, 1H),
7.44 (d, J = 7.8Hz, 1H), 5.96 (bs, 1H), 4.53 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H), 2.26 (q, J = 7.8Hz, 2H),
1.17 (t, J = 7.8Hz, 3H).
2-106 δ7.83 (s, 1H), 7.3-7.6 (m, 5H), 6.10 (t, J = 6.6Hz, 1H),
4.50 (d, J = 6.6Hz, 2H), 4.04 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
2.26 (q, J = 7.8Hz, 2H), 1.17 (t, J = 7.8Hz, 3H).
2-107 δ7.85 (d, J = 1.8Hz, 1H), 7.62 (s, 2H), 7.55 (dd, J = 8.1, 1.8Hz, 1H),
7.45 (d, J = 8.1Hz, 1H), 5.96 (t, J = 6.2Hz, 1H), 4.52 (d, J = 6.2Hz, 2H),
4.05 (d, J = 17.2Hz, 1H), 3.65 (d, J = 17.2Hz, 1H), 2.26 (q, J = 7.5Hz, 2H),
1.17 (t, J = 7.5Hz, 3H).
2-108 δ8.28 (s, 1H), 7.92 (d, J = 8.4Hz, 1H), 7.77 (d, J = 8.4Hz, 1H),
7.64 (s, 2H), 6.29 (t, J = 6.6Hz, 1H), 4.69 (d, J = 6.6Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.71 (d, J = 17.4Hz, 1H), 2.28 (q, J = 7.8Hz, 2H),
1.14 (t, J = 7.8Hz, 3H).
2-109 δ7.65 (s, 2H), 7.60 (d, J = 8.1Hz, 2H), 7.35 (d, J = 8.1Hz, 2H),
5.85 (d, J = 7.8Hz, 1H), 5.05-5.2 (m, 1H), 4.05 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 2.20 (q, J = 7.5Hz, 2H), 1.45 (d, J = 7.2Hz, 3H),
1.15 (t, J = 7.5Hz, 3H).
2-112 δ7.85 (d, J = 1.8Hz, 1H), 7.62 (s, 2H), 7.55 (dd, J = 8.1, 1.8Hz, 1H),
7.45 (d, J = 8.1Hz, 1H), 5.95 (t, J = 6.2Hz, 1H), 4.52 (d, J = 6.2Hz, 2H),
4.05 (d, J = 17.2Hz, 1H), 3.65 (d, J = 17.2Hz, 1H), 2.20 (t, J = 7.5Hz, 2H),
1.6-1.75 (m, 2H), 0.94 (t, J = 7.4Hz, 3H).
2-113 δ8.27 (s, 1H), 7.91 (d, J = 8.4Hz, 1H), 7.76 (d, J = 8.4Hz, 1H),
7.64 (s, 2H), 6.35 (t, J = 6.3Hz, 1H), 4.69 (d, J = 6.3Hz, 2H),
4.11 (d, J = 17.7Hz, 1H), 3.73 (d, J = 17.7Hz, 1H), 2.18 (t, J = 7.5Hz, 2H),
1.5-1.8 (m, 2H), 0.91 (t, J = 7.5Hz, 3H).
2-114 δ7.65 (s, 2H), 7.60 (d, J = 8.1Hz, 2H), 7.35 (d, J = 8.1Hz, 2H),
5.75 (d, J = 7.5Hz, 1H), 5.1-5.2 (m, 1H), 4.05 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 2.15 (t, J = 7.5Hz, 2H), 1.65 (q, J = 7.5Hz, 2H),
1.50 (d, J = 7.2Hz, 3H), 0.95 (t, J = 7.5Hz, 3H).
2-118 δ8.27 (s, 1H), 7.91 (d, J = 8.4Hz, 1H), 7.76 (d, J = 8.4Hz, 1H),
7.64 (s, 2H), 6.29 (t, J = 6.0Hz, 1H), 4.68 (d, J = 6.0Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.71 (d, J = 17.4Hz, 1H),
2.38 (sep, J = 7.2Hz, 1H), 1.12 (d, J = 7.2Hz, 6H).
2-120 δ7.64 (s, 2H), 7.62 (d, J = 8.4Hz, 2H), 7.35 (d, J = 8.4Hz, 2H),
5.93 (bs, 1H), 4.49 (d, J = 5.7Hz, 2H), 4.08 (d, J = 17.4Hz, 1H),
3.67 (d, J = 17.4Hz, 1H), 1.3-1.45 (m, 1H), 0.95-1.05 (m, 2H),
0.75-0.85 (m, 2H).
2-121 δ7.86 (s, 1H), 7.80 (d, J = 7.5Hz, 1H), 7.70 (d, J = 1.8Hz, 1H),
7.69 (d, J = 7.5Hz, 1H), 7.59 (t, J = 7.5Hz, 1H),
7.51 (dd, J = 8.0, 1.8Hz, 1H), 7.45 (d, J = 8.0Hz, 1H),
6.12 (t, J = 6.1Hz, 1H), 4.55 (d, J = 6.1Hz, 2H), 4.10 (d, J = 17.5Hz, 1H),
3.71 (d, J = 17.5Hz, 1H), 1.3-1.45 (m, 1H), 0.95-1.1 (m, 2H),
0.7-0.85 (m, 2H).
2-123 δ7.68 (d, J = 1.5Hz, 1H), 7.50 (s, 2H), 7.45-7.5 (m, 1H),
7.45 (d, J = 8.1Hz, 1H), 6.13 (bs, 2H), 4.55 (d, J = 6.3Hz, 2H),
4.01 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H), 1.35-1.45 (m, 1H),
0.95-1.05 (m, 2H), 0.7-0.85 (m, 2H).
2-124 δ7.67 (d, J = 1.5Hz, 1H), 7.64 (s, 2H), 7.50 (dd, J = 8.1, 1.5Hz, 1H),
7.46 (d, J = 8.1Hz, 1H), 6.61 (t, J = 73.5Hz, 1H), 6.17 (t, J = 6.0Hz, 1H),
4.54 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
1.35-1.45 (m, 1H), 0.95-1.05 (m, 2H), 0.7-0.85 (m, 2H).
2-125 δ7.67 (d, J = 1.5Hz, 1H), 7.66 (s, 2H), 7.49 (dd, J = 7.8, 1.5Hz, 1H),
7.45 (d, J = 7.8Hz, 1H), 6.21 (bs, 1H), 4.54 (d, J = 6.0Hz, 2H),
4.06 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H), 3.48 (s, 3H),
1.35-1.45 (m, 1H), 0.95-1.05 (m, 2H), 0.7-0.85 (m, 2H).
2-126 δ7.68 (d, J = 1.5Hz, 1H), 7.60 (s, 2H), 7.50 (dd, J = 8.4, 1.5Hz, 1H),
7.46 (d, J = 8.4Hz, 1H), 6.09 (bs, 1H), 4.55 (d, J = 6.0Hz, 2H),
4.04 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H), 2.46 (s, 3H),
1.3-1.45 (m, 1H), 0.95-1.05 (m, 2H), 0.7-0.85 (m, 2H).
2-127 δ7.67 (d, J = 1.5Hz, 1H), 7.60 (s, 2H), 7.50 (dd, J = 8.4, 1.5Hz, 1H),
7.45 (d, J = 8.4Hz, 1H), 6.23 (t, J = 6.0Hz, 1H), 4.54 (d, J = 6.3Hz, 2H),
4.07 (d, J = 17.4Hz, 1H), 3.67 and 3.66 (d, J = 17.4Hz, 1H),
3.07 and 3.06 (s, 3H), 1.35-1.45 (m, 1H), 0.9-1.05 (m, 2H),
0.7-0.8 (m, 2H).
2-128 δ7.73 (s, 2H), 7.67 (d, J = 1.5Hz, 1H), 7.50 (dd, J = 8.4, 1.5Hz, 1H),
7.46 (d, J = 8.1Hz, 1H), 6.16 (t, J = 6.0Hz, 1H), 4.50 (d, J = 6.6Hz, 2H),
4.09 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 3.35 (s, 3H),
1.35-1.45 (m, 1H), 0.95-1.05 (m, 2H), 0.7-0.85 (m, 2H).
2-130 δ8.29 (s, 1H), 7.92 (d, J = 8.4Hz, 1H), 7.76 (d, J = 8.4Hz, 1H),
7.64 (s, 2H), 6.48 (t, J = 6.3Hz, 1H), 4.71 (d, J = 6.3Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H), 1.3-1.5 (m, 1H),
0.9-1.1 (m, 2H), 0.7-0.9 (m, 2H).
2-132 δ9.90 (bs, 1H), 8.00 (bs, 1H), 7.81 (dd, J = 8.4, 1.5Hz, 1H),
7.75 (d, J = 1.5Hz, 1H), 7.48 (s, 2H), 7.42 (t, J = 1.5Hz, 1H),
7.37 (d, J = 8.4Hz, 1H), 6.71 (bs, 1H), 4.41 (d, J = 5.1Hz, 2H),
4.09 (d, J = 17.4Hz, 1H), 3.71 (d, J = 17.4Hz, 1H), 1.35-1.45 (m, 1H),
0.85-0.95 (m, 2H), 0.75-0.85 (m, 2H).
2-133 δ8.08 (s, 2H), 7.95 (s, 1H), 7.63 (d, J = 8.7Hz, 2H),
7.38 (d, J = 8.7Hz, 2H), 5.95 (d, J = 7.2Hz, 1H), 5.05-5.2 (m, 1H),
4.17 (d, J = 17.4Hz, 1H), 3.73 (d, J = 17.4Hz, 1H), 1.49 (d, J = 7.2Hz, 3H),
1.3-1.45 (m, 1H), 0.85-1.05 (m, 2H), 0.65-0.8 (m, 2H).
2-134 δ7.63 (s, 2H), 7.62 (d, J = 8.7Hz, 2H), 7.38 (d, J = 8.7Hz, 2H),
5.83 (d, J = 7.2Hz, 1H), 5.05-5.2 (m, 1H), 4.06 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 1.49 (d, J = 7.2Hz, 3H), 1.25-1.4 (m, 1H),
0.85-1.0 (m, 2H), 0.7-0.8 (m, 2H).
2-135 δ7.3-7.6 (m, 6H), 5.84 (d, J = 6.9Hz, 1H), 5.2-5.35 (m, 1H),
4.06 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 2.42 (s, 3H),
1.45 (d, J = 6.9Hz, 3H), 1.2-1.4 (m, 1H), 0.8-1.05 (m, 2H),
0.65-0.8 (m, 2H).
2-136 (CDCl _Three , Me _Four Si, 400MHz) δ7.55-7.6 (m, 2H), 7.5-7.55 (m, 2H),
7.35-7.4 (m, 3H), 6.46 (d, J = 12.0Hz, 1H), 6.2-6.3 (m, 1H),
5.72 (bs, 1H), 4.36 (q, J = 6.0Hz, 2H), 4.08 (d, J = 17.3Hz, 1H),
3.69 (d, J = 17.3Hz, 1H), 2.46 (q, J = 6.0Hz, 2H), 1.25-1.4 (m, 1H),
0.9-1.0 (m, 2H), 0.7-0.8 (m, 2H).
2-138 δ8.85 and 8.77 (d, J = 3.0Hz, 1H), 7.6-7.7 (m, 3H), 7.4-7.6 (m, 5H),
6.12 and 6.10 (d, J = 7.8Hz, 1H), 4.06 and 4.05 (d, J = 17.4Hz, 1H),
3.67 and 3.65 (d, J = 17.4Hz, 1H), 1.55-1.7 (m, 1H), 0.8-0.95 (m, 4H).
2-140 δ7.67 (d, J = 1.5Hz, 1H), 7.62 (s, 2H), 7.50 (dd, J = 7.8, 1.5Hz, 1H),
7.45 (d, J = 7.8Hz, 1H), 5.96 (t, J = 6.0Hz, 1H), 4.53 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 2.05-2.2 (m, 3H),
0.93 (t, J = 6.6Hz, 6H).
2-141 δ7.85 (d, J = 1.8Hz, 1H), 7.62 (s, 2H), 7.55 (dd, J = 8.1, 1.8Hz, 1H),
7.46 (d, J = 8.1Hz, 1H), 5.93 (t, J = 6.2Hz, 1H), 4.52 (d, J = 6.2Hz, 2H),
4.05 (d, J = 17.5Hz, 1H), 3.65 (d, J = 17.5Hz, 1H), 2.0-2.2 (m, 3H),
0.94 (d, J = 6.2Hz, 6H).
2-142 δ7.65 (s, 2H), 7.60 (d, J = 8.4Hz, 2H), 7.35 (d, J = 8.4Hz, 2H),
5.70 (d, J = 7.5Hz, 1H), 5.1-5.15 (m, 1H), 4.05 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 2.05-2.15 (m, 3H), 1.45 (d, J = 6.9Hz, 3H),
0.95 (d, J = 6.3Hz, 3H), 0.90 (d, J = 6.3Hz, 3H).
2-144 δ7.69 (d, J = 1.5Hz, 1H), 7.63 (s, 2H), 7.50 (dd, J = 7.8, 1.5Hz, 1H),
7.46 (d, J = 7.8Hz, 1H), 6.45 (t, J = 6.0Hz, 1H), 4.56 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 2.20 (d, J = 7.2Hz, 2H),
0.9-1.05 (m, 1H), 0.55-0.7 (m, 2H), 0.15-0.25 (m, 2H).
2-145 δ7.86 (d, J = 1.8Hz, 1H), 7.62 (s, 2H), 7.55 (dd, J = 8.1, 1.8Hz, 1H),
7.46 (d, J = 8.1Hz, 1H), 6.49 (t, J = 6.2Hz, 1H), 4.54 (d, J = 6.2Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H), 2.20 (d, J = 7.2Hz, 2H),
0.9-1.05 (m, 1H), 1.55-1.7 (m, 2H), 0.15-0.35 (m, 2H).
2-146 δ8.28 (s, 1H), 7.92 (d, J = 8.4Hz, 1H), 7.77 (d, J = 8.4Hz, 1H),
7.64 (s, 2H), 6.78 (t, J = 6.3Hz, 1H), 4.72 (d, J = 6.3Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.71 (d, J = 17.4Hz, 1H), 2.16 (d, J = 7.2Hz, 2H),
0.8-1.0 (m, 1H), 0.55-0.7 (m, 2H), 0.15-0.25 (m, 2H).
2-147 δ8.08 (s, 2H), 7.96 (s, 1H), 7.65 (d, J = 8.4Hz, 2H),
7.39 (d, J = 8.4Hz, 2H), 6.09 (d, J = 8.1Hz, 1H), 5.1-5.2 (m, 1H),
4.18 (d, J = 17.1Hz, 1H), 3.73 (d, J = 17.1Hz, 1H), 2.17 (d, J = 7.2Hz, 2H),
1.50 (d, J = 6.9Hz, 3H), 0.9-1.0 (m, 1H), 0.6-0.65 (m, 2H),
0.15-0.25 (m, 2H).
2-148 δ7.65 (s, 2H), 7.60 (d, J = 8.1Hz, 2H), 7.40 (d, J = 8.1Hz, 2H),
6.10 (d, J = 7.8Hz, 1H), 5.15-5.25 (m, 1H), 4.05 (d, J = 17.1Hz, 1H),
3.70 (d, J = 17.1Hz, 1H), 2.20 (d, J = 7.2Hz, 2H), 1.50 (d, J = 7.2Hz, 3H),
0.95-1.0 (m, 1H), 0.6-0.65 (m, 2H), 0.2-0.25 (m, 2H).
2-149 δ7.72 (d, J = 8.4Hz, 2H), 7.63 (s, 2H), 7.55 (d, J = 8.4Hz, 2H),
6.49 (d, J = 9.0Hz, 1H), 6.26 (d, J = 9.0Hz, 1H), 4.08 (d, J = 17.4Hz, 1H),
3.68 (d, J = 17.4Hz, 1H), 2.26 (d, J = 7.2Hz, 2H), 0.9-1.05 (m, 1H),
0.55-0.7 (m, 2H), 0.15-0.3 (m, 2H).
2-151 δ7.68 (s, 1H), 7.63 (s, 2H), 7.4-7.55 (m, 2H), 6.03 (bs, 1H),
4.54 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H),
1.3-1.45 (m, 1H), 1.1-1.2 (m, 2H), 1.09 (d, J = 6.0Hz, 3H),
0.55-0.65 (m, 1H).
2-153 δ7.4-7.75 (m, 5H), 6.00 (bs, 1H), 4.50 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H),
3.04 (qui, J = 8.4Hz, 1H), 1.75-2.35 (m, 6H).
2-154 δ7.84 (d, J = 1.8Hz, 1H), 7.62 (s, 2H), 7.55 (dd, J = 8.1, 1.8Hz, 1H),
7.43 (d, J = 8.1Hz, 1H), 5.85 (t, J = 6.3Hz, 1H), 4.50 (d, J = 6.3Hz, 2H),
4.04 (d, J = 17.7Hz, 1H), 3.64 (d, J = 17.7Hz, 1H), 2.95-3.1 (m, 1H),
1.8-2.35 (m, 6H).
2-156 δ7.67 (s, 1H), 7.62 (s, 2H), 7.48 (d, J = 7.8Hz, 1H),
7.44 (d, J = 7.8Hz, 1H), 6.06 (t, J = 6.0Hz, 1H),
4.57 (dd, J = 15.6, 6.3Hz, 1H), 4.51 (dd, J = 15.6, 6.3Hz, 1H),
4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H), 1.2-1.35 (m, 1H),
1.15 (s, 3H), 1.14 (s, 3H), 1.1-1.15 (m, 1H),
0.76 (dd, J = 8.1, 4.5Hz, 1H).
2-158 δ7.6-7.7 (m, 3H), 7.4-7.55 (m, 2H), 7.13 (bs, 1H),
4.59 (d, J = 6.0Hz, 2H), 4.09 (s, 2H), 4.06 (d, J = 17.3Hz, 1H),
3.67 (d, J = 17.3Hz, 1H).
2-159 δ7.35-7.7 (m, 5H), 7.05 (bs, 1H), 4.63 (d, J = 6.3Hz, 2H),
4.07 (d, J = 17.3Hz, 1H), 3.68 (d, J = 17.3Hz, 1H).
2-160 δ7.90 (d, J = 1.8Hz, 1H), 7.62 (s, 2H), 7.59 (dd, J = 8.1, 1.8Hz, 1H),
7.45 (d, J = 8.1Hz, 1H), 6.80 (bs, 1H), 4.63 (d, J = 6.2Hz, 2H),
4.06 (d, J = 17.2Hz, 1H), 3.66 (d, J = 17.2Hz, 1H).
2-161 δ7.74 (d, J = 1.2Hz, 1H), 7.62 (s, 2H), 7.45-7.6 (m, 2H),
6.73 (bs, 1H), 4.64 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H).
2-162 δ7.71 (t, J = 1.8Hz, 1H), 7.5-7.55 (m, 1H), 7.35-7.45 (m, 2H),
7.21 (s, 1H), 6.91 (bs, 1H), 4.63 (d, J = 6.3Hz, 2H),
4.06 (d, J = 17.4Hz, 1H), 3.71 (d, J = 17.4Hz, 1H), 2.48 (s, 3H),
2.39 (d, J = 0.6Hz, 3H).
2-163 δ7.6-7.7 (m, 3H), 7.4-7.5 (m, 2H), 6.29 (bs, 1H), 4.5-4.6 (m, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.81 (td, J = 6.3, 2.1Hz, 2H),
3.66 (d, J = 17.3Hz, 1H), 2.68 (t, J = 6.3Hz, 2H).
2-164 δ7.6-7.7 (m, 3H), 7.4-7.5 (m, 1H), 7.3-7.4 (m, 1H), 6.68 (bs, 1H),
4.52 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.3Hz, 1H), 3.68 (d, J = 17.3Hz, 1H),
3.11 (q, J = 10.8Hz, 2H).
2-167 δ7.65 (s, 2H), 7.60 (d, J = 8.7Hz, 2H), 7.35 (d, J = 8.7Hz, 2H),
6.05 (d, J = 7.5Hz, 1H), 5.1-5.2 (m, 1H), 4.05 (d, J = 17.8Hz, 1H),
3.65 (d, J = 17.8Hz, 1H), 3.10 (q, J = 10.5Hz, 2H), 1.50 (d, J = 7.2Hz, 3H).
2-168 δ7.73 (d, J = 8.4Hz, 2H), 7.63 (s, 2H), 7.53 (d, J = 8.4Hz, 2H),
6.75 (d, J = 8.7Hz, 1H), 6.20 (d, J = 8.7Hz, 1H), 4.08 (d, J = 17.4Hz, 1H),
3.69 (d, J = 17.4Hz, 1H), 3.1-3.25 (m, 2H).
2-169 δ7.73 (d, J = 1.5Hz, 1H), 7.62 (s, 2H), 7.52 (dd, J = 7.8, 1.5Hz, 1H),
7.43 (d, J = 7.8Hz, 1H), 6.92 (bs, 1H), 4.66 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H).
2-171 δ7.6-7.7 (m, 3H), 7.45-7.55 (m, 1H), 7.3-7.4 (m, 1H), 6.38 (bs, 1H),
4.51 (q, J = 3.0Hz, 2H), 4.06 (d, J = 17.3Hz, 1H), 3.66 (d, J = 17.3Hz, 1H),
2.4-2.65 (m, 4H).
2-173 δ7.65 (s, 2H), 7.60 (d, J = 8.4Hz, 2H), 7.35 (d, J = 8.4Hz, 2H),
5.80 (d, J = 7.8Hz, 1H), 5.05-5.15 (m, 1H), 4.05 (d, J = 17.1Hz, 1H),
3.65 (d, J = 17.1Hz, 1H), 2.35-2.55 (m, 4H), 1.50 (d, J = 6.6Hz, 3H).
2-174 δ7.6-7.7 (m, 3H), 7.4-7.5 (m, 2H), 7.00 (bs, 1H), 4.59 (d, J = 6.0Hz, 2H),
4.17 (s, 2H), 4.06 (d, J = 17.3Hz, 1H), 3.93 (q, J = 8.4Hz, 2H),
3.68 (d, J = 17.3Hz, 1H).
2-175 δ7.6-7.75 (m, 3H), 7.4-7.5 (m, 2H), 7.00 (bs, 1H),
4.58 (d, J = 6.0Hz, 2H), 4.24 (d, J = 2.4Hz, 2H), 4.10 (s, 2H),
4.06 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H), 2.50 (t, J = 2.4Hz, 1H).
2-176 δ7.64 (m, 2H), 7.62 (d, J = 8.4Hz, 2H), 7.46 (d, J = 8.4Hz, 2H),
6.04 (bs, 1H), 4.46 (d, J = 6.0Hz, 2H), 4.07 (d, J = 17.4Hz, 1H),
3.75-4.0 (m, 4H), 3.67 (d, J = 17.4Hz, 1H), 2.9-3.0 (m, 1H),
2.1-2.25 (m, 2H).
2-178 δ7.69 (d, J = 1.5Hz, 1H), 7.62 (s, 2H), 7.50 (dd, J = 7.8, 1.5Hz, 1H),
7.44 (d, J = 7.8Hz, 1H), 6.17 (bs, 1H), 4.52 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 3.75-4.0 (m, 4H),
2.85-3.0 (m, 1H), 2.1-2.25 (m, 2H).
2-179 δ7.86 (s, 1H), 7.63 (s, 2H), 7.56 (d, J = 8.1Hz, 1H),
7.43 (d, J = 8.1Hz, 1H), 6.22 (bs, 1H), 4.51 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.75-4.0 (m, 4H), 3.65 (d, J = 17.3Hz, 1H),
2.85-3.0 (m, 1H), 2.05-2.25 (m, 2H).
2-180 δ8.28 (s, 1H), 7.93 (d, J = 8.4Hz, 1H), 7.75 (d, J = 8.4Hz, 1H),
7.64 (s, 2H), 6.49 (t, J = 6.3Hz, 1H), 4.69 (d, J = 6.3Hz, 2H),
4.11 (d, J = 17.4Hz, 1H), 3.7-4.05 (m, 4H), 3.72 (d, J = 17.4Hz, 1H),
2.85-2.95 (m, 1H), 2.0-2.3 (m, 2H).
2-181 δ7.63 (s, 2H), 7.62 (d, J = 8.1Hz, 2H), 7.35 (dd, J = 8.1, 2.1Hz, 2H),
5.90 (d, J = 7.8Hz, 1H), 5.05-5.15 (m, 1H), 4.05 (d, J = 17.7Hz, 1H),
3.75-4.15 (m, 4H), 3.65 (d, J = 17.7Hz, 1H), 2.85-2.95 (m, 1H),
2.05-2.15 (m, 2H), 1.45-1.5 (m, 3H).
2-182 δ7.80 (s, 1H), 7.35-7.6 (m, 5H), 7.26 (t, J = 5.7Hz, 1H),
4.52 (d, J = 5.7Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.97 (s, 2H),
3.68 (d, J = 17.4Hz, 1H), 3.07 (s, 3H).
2-183 δ7.4-7.8 (m, 7H), 4.56 (d, J = 6.3Hz, 2H), 4.06 (d, J = 17.3Hz, 1H),
3.68 (d, J = 17.3Hz, 1H), 3.26 (s, 2H), 2.53 (q, J = 7.4Hz, 2H),
1.23 (t, J = 7.4Hz, 3H).
2-184 δ7.75-7.8 (m, 1H), 7.67 (s, 1H), 7.35-7.5 (m, 2H), 7.1-7.3 (m, 3H),
4.53 (d, J = 6.0Hz, 2H), 4.03 (d, J = 17.3Hz, 1H), 3.68 (d, J = 13.6Hz, 1H),
3.66 (d, J = 17.3Hz, 1H), 3.40 (d, J = 13.6Hz, 1H), 2.75-2.85 (m, 2H),
1.29 (t, J = 7.4Hz, 3H).
2-185 δ7.9-8.1 (m, 2H), 7.2-7.7 (m, 5H), 4.58 (d, J = 6.0Hz, 2H),
4.04 (d, J = 17.3Hz, 1H), 3.97 (s, 2H), 3.66 (d, J = 17.3Hz, 1H),
3.20 (q, J = 7.5Hz, 2H), 1.41 (t, J = 7.5Hz, 3H).
2-186 δ7.70 (s, 1H), 7.4-7.55 (m, 6H), 4.57 (d, J = 6.0Hz, 2H),
4.06 (d, J = 17.3Hz, 1H), 3.69 (d, J = 17.3Hz, 1H), 3.25 (s, 2H),
2.48 (t, J = 4.5Hz, 2H), 1.58 (sxt, J = 4.5Hz, 2H), 0.94 (t, J = 4.5Hz, 3H).
2-187 δ7.70 (s, 1H), 7.4-7.55 (m, 6H), 4.56 (d, J = 6.0Hz, 2H),
4.06 (d, J = 17.3Hz, 1H), 3.69 (d, J = 17.3Hz, 1H), 3.28 (s, 2H),
2.88 (sep, J = 6.5Hz, 1H), 1.22 (d, J = 6.5Hz, 6H).
2-188 δ7.68 (s, 1H), 7.1-7.55 (m, 11H), 4.44 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.69 (s, 2H), 3.67 (d, J = 17.3Hz, 1H),
3.16 (s, 2H).
2-189 δ7.62 (s, 1H), 7.35-7.55 (m, 10H), 7.26 (bs, 1H), 4.51 (d, J = 5.7Hz, 2H),
4.41 (s, 2H), 4.03 (d, J = 17.3Hz, 1H), 3.81 (s, 2H),
3.65 (d, J = 17.3Hz, 1H).
2-190 δ7.05-7.6 (m, 12H), 4.50 (d, J = 6.3Hz, 2H), 4.02 (d, J = 17.3Hz, 1H),
3.67 (s, 2H), 3.64 (d, J = 17.3Hz, 1H).
2-191 δ7.3-7.85 (m, 12H), 4.45-4.55 (m, 2H), 4.07 (s, 2H),
4.06 (d, J = 17.3Hz, 1H), 3.68 (d, J = 17.3Hz, 1H).
2-193 δ7.4-7.7 (m, 7H), 4.59 (d, J = 5.7Hz, 2H), 4.05 (d, J = 17.3Hz, 1H),
3.66 (d, J = 17.3Hz, 1H), 3.23 (q, J = 7.1Hz, 1H), 2.59 (s, 3H),
1.63 (d, J = 7.1Hz, 3H).
2-194 δ7.35-7.65 (m, 6H), 7.27 (bs, 1H), 4.4-4.65 (m, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.84 (q, J = 7.2Hz, 1H), 3.68 (d, J = 17.3Hz, 1H),
2.88 (s, 3H), 1.62 (d, J = 7.2Hz, 3H).
2-195 δ7.4-7.75 (m, 6H), 4.81 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.3Hz, 1H),
3.67 (d, J = 17.3Hz, 1H), 1.96 (s, 3H), 1.50 (s, 6H).
2-196 δ7.4-7.7 (m, 6H), 7.2-7.3 (m, 1H), 4.57 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H), 2.85 (s, 3H),
1.65 (s, 6H).
2-197 δ7.68 (s, 1H), 7.62 (s, 2H), 7.50 (s, 2H), 6.21 (bs, 1H),
4.55 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H),
2.80 (t, J = 7.2Hz, 2H), 2.52 (t, J = 7.2Hz, 2H), 2.11 (s, 3H).
2-198 δ7.72 (d, J = 8.4Hz, 2H), 7.63 (s, 2H), 7.56 (d, J = 8.4Hz, 2H),
6.50 (bs, 1H), 6.23 (d, J = 9.0Hz, 1H), 4.08 (d, J = 17.4Hz, 1H),
3.68 (d, J = 17.4Hz, 1H), 2.75-2.85 (m, 2H), 2.5-2.65 (m, 2H),
2.13 (s, 3H).
2-199 δ7.6-7.7 (m, 3H), 7.4-7.55 (m, 2H), 4.56 (d, J = 6.6Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.66 (d, J = 17.3Hz, 1H), 2.99 (s, 2H),
2.28 (s, 6H).
2-200 δ7.80 (t, J = 6.0Hz, 1H), 7.69 (d, J = 1.5Hz, 1H), 7.64 (s, 2H),
7.4-7.55 (m, 2H), 4.56 (d, J = 6.0Hz, 2H), 4.07 (d, J = 17.4Hz, 1H),
3.68 (d, J = 17.4Hz, 1H), 3.03 (s, 2H), 248 (q, J = 7.2Hz, 2H),
2.27 (s, 3H), 1.04 (t, J = 7.2Hz, 3H).
2-201 δ7.95 (bs, 1H), 7.6-7.75 (m, 3H), 7.35-7.55 (m, 2H),
4.55 (d, J = 6.6Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H),
3.07 (s, 2H), 2.55 (q, J = 7.2Hz, 4H), 1.01 (t, J = 7.2Hz, 6H).
2-202 δ7.4-7.75 (m, 6H), 4.56 (dd, J = 6.3, 2.4Hz, 2H), 4.06 (d, J = 17.4Hz, 1H),
3.67 (d, J = 17.4Hz, 1H), 3.44 (s, 2H), 3.21 (q, J = 9.3Hz, 2H),
1.93 (bs, 1H).
2-203 δ7.69 (d, J = 0.9Hz, 1H), 7.62 (s, 2H), 7.4-7.55 (m, 2H),
7.23 (t, J = 6.3Hz, 1H), 4.56 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 3.61 (s, 2H), 3.46 (s, 2H), 1.99 (bs, 1H).
2-204 δ7.6-7.7 (m, 3H), 7.3-7.5 (m, 2H), 4.45-4.6 (m, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H), 3.43 (s, 2H),
3.42 (d, J = 2.4Hz, 2H), 2.23 (t, J = 2.4Hz, 1H).
2-205 δ7.35-7.8 (m, 6H), 4.56 (d, J = 6.0Hz, 2H), 4.07 (d, J = 17.4Hz, 1H),
3.69 (d, J = 17.4Hz, 1H), 3.20 (s, 2H), 2.5-2.7 (m, 4H), 1.7-1.9 (m, 4H).
2-206 δ7.6-7.7 (m, 3H), 7.35-7.5 (m, 2H), 6.89 (bs, 1H), 4.57 (bs, 1H),
4.52 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.3Hz, 1H), 3.88 (d, J = 5.4Hz, 2H),
3.69 (d, J = 17.3Hz, 1H), 3.68 (s, 3H).
2-207 δ7.65-7.7 (m, 3H), 7.45-7.55 (m, 1H), 7.35-7.45 (m, 1H), 6.80 (bs, 1H),
4.53 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.93 (s, 2H),
3.71 (s, 3H), 3.68 (d, J = 17.4Hz, 1H), 2.98 (t, J = 1.5Hz, 3H).
2-208 δ7.66 (s, 1H), 7.63 (s, 2H), 7.35-7.55 (m, 2H), 6.88 (bs, 1H),
4.53 (d, J = 6.3Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.91 (s, 2H),
3.72 (s, 3H), 3.67 (d, J = 17.4Hz, 1H), 3.66 (q, J = 7.2Hz, 2H),
1.11 (t, J = 7.2Hz, 3H).
2-209 δ7.69 (s, 1H), 7.62 (s, 2H), 7.4-7.55 (m, 2H), 6.2-6.5 (m, 1H),
4.55 (d, J = 6.0Hz, 2H), 4.36 (s, 2H), 4.06 (d, J = 17.4Hz, 1H),
4.04 (s, 2H), 3.79 (bs, 3H), 3.67 (d, J = 17.4Hz, 1H).
2-210 δ7.67 (s, 1H), 7.4-7.55 (m, 5H), 5.01 (s, 1H),
4.53 (dd, J = 6.3, 2.7Hz, 2H), 4.49 (d, J = 17.3Hz, 1H),
3.67 (d, J = 17.3Hz, 1H), 3.4-3.5 (m, 1H), 2.95-3.05 (m, 2H),
2.75-2.85 (m, 1H), 2.42 (bs, 1H).
2-211 δ7.4-7.7 (m, 6H), 7.05 (bs, 1H), 5.55 (s, 1H), 4.50 (d, J = 5.7Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.9-4.05 (m, 1H), 3.7-3.85 (m, 1H),
3.68 (d, J = 17.3Hz, 1H), 3.45-3.55 (m, 1H), 3.05-3.15 (m, 1H),
2.13 (s, 3H).
2-212 δ7.64 (s, 1H), 7.4-7.55 (m, 5H), 6.79 (bs, 1H), 5.36 (s, 1H),
4.51 (dd, J = 6.0, 4.2Hz, 2H), 4.06 (d, J = 17.3Hz, 1H), 3.8-3.95 (m, 2H),
3.71 (s, 3H), 3.68 (d, J = 17.3Hz, 1H), 3.24 (bs, 1H), 2.95-3.05 (m, 1H).
2-213 δ7.35-7.7 (m, 7H), 4.4-4.6 (m, 2H), 4.15-4.3 (m, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.95 (d, J = 9.8Hz, 1H), 3.67 (d, J = 17.3Hz, 1H),
3.4-3.5 (m, 1H), 3.05-3.15 (m, 1H), 2.44 (bs, 1H).
2-214 δ7.3-7.7 (m, 6H), 6.92 (bs, 1H), 4.95-5.05 (m, 1H), 4.4-4.7 (m, 4H),
4.05 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H), 3.57 (d, J = 10.4Hz, 1H),
3.05-3.15 (m, 1H), 2.31 (s, 3H).
2-215 δ7.71 (d, J = 1.5Hz, 1H), 7.62 (s, 2H), 7.54 (dd, J = 8.1, 1.5Hz, 1H),
7.46 (d, J = 8.1Hz, 1H), 6.58 (bs, 1H), 4.59 (d, J = 6.3Hz, 2H),
4.04 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H), 3.41 (s, 2H).
2-216 δ7.66 (d, J = 1.5Hz, 1H), 7.63 (s, 2H), 7.4-7.5 (m, 2H), 6.32 (bs, 1H),
4.53 (d, J = 6.3Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.68 (s, 3H),
3.67 (d, J = 17.4Hz, 1H), 2.69 (t, J = 6.6Hz, 2H), 2.53 (t, J = 6.6Hz, 2H).
2-217 δ7.96 (bs, 1H), 7.55-7.65 (m, 3H), 7.45-7.5 (m, 1H), 7.35-7.4 (m, 1H),
7.02 (bs, 1H), 4.51 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.67 (d, J = 17.4Hz, 1H), 3.24 (s, 2H), 2.80 (dd, J = 4.8, 0.9Hz, 3H).
2-218 δ7.92 (d, J = 5.4Hz, 1H), 7.64 (s, 1H), 7.63 (s, 2H), 7.55-7.65 (m, 1H),
7.45-7.55 (m, 1H), 6.28 (bs, 1H), 4.53 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
3.28 (qd, J = 7.2, 5.4Hz, 2H), 3.22 (s, 2H), 1.42 (t, J = 7.2Hz, 3H).
2-219 δ7.96 (t, J = 5.7Hz, 1H), 7.6-7.7 (m, 3H), 7.45-7.55 (m, 1H),
7.35-7.45 (m, 1H), 6.91 (bs, 1H), 4.53 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 3.25 (s, 2H),
3.05-3.15 (m, 2H), 0.90-1.05 (m, 1H), 0.5-0.6 (m, 2H),
0.15-0.25 (m, 2H).
2-220 δ7.69 (s, 1H), 7.56 (t, J = 8.1Hz, 1H), 7.25-7.55 (m, 5H),
7.14 (t, J = 6.6Hz, 1H), 4.55 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.1Hz, 1H),
3.85-4.0 (m, 2H), 3.65 (d, J = 17.1Hz, 1H), 3.30 (s, 2H).
2-221 δ7.6-7.7 (m, 3H), 7.4-7.55 (m, 2H), 4.58 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 3.45-3.55 (m, 4H),
3.32 (s, 2H), 1.85-2.05 (m, 4H).
2-222 δ7.68 (s, 1H), 7.62 (s, 2H), 7.45-7.55 (m, 2H),
6.32 (dd, J = 17.1, 1.2Hz, 1H), 6.12 (dd, J = 17.1, 10.2Hz, 1H),
6.10 (bs, 1H), 5.70 (dd, J = 10.2, 1.2Hz, 1H), 4.61 (d, J = 6.6Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H).
2-223 δ7.85 (d, J = 1.8Hz, 1H), 7.62 (s, 2H), 7.55 (dd, J = 8.1, 1.8Hz, 1H),
7.47 (d, J = 8.1Hz, 1H), 6.32 (dd, J = 17.0, 1.2Hz, 1H),
6.12 (dd, J = 17.0, 10.2Hz, 1H), 6.09 (bs, 1H),
5.69 (dd, J = 10.2, 1.2Hz, 1H), 4.61 (d, J = 6.5Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H).
2-224 δ7.6-7.75 (m, 3H), 7.4-7.55 (m, 2H), 6.18 (t, J = 6.0Hz, 1H),
5.8-6.05 (m, 1H), 5.15-5.3 (m, 2H), 4.52 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.66 (d, J = 17.3Hz, 1H), 3.05 (d, J = 6.6Hz, 2H).
2-225 δ7.6-7.7 (m, 3H), 7.35-7.5 (m, 2H), 6.85 (dq, J = 15.3, 6.9Hz, 1H),
6.31 (t, J = 6.0Hz, 1H), 5.86 (dd, J = 15.3, 1.8Hz, 1H),
4.54 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H),
1.84 (dd, J = 6.9, 1.8Hz, 3H).
2-226 δ7.68 (s, 1H), 7.62 (s, 2H), 7.4-7.55 (m, 2H), 6.34 (bs, 1H),
5.72 (s, 1H), 5.37 (s, 1H), 4.58 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H), 1.98 (s, 3H).
2-227 δ7.96 (ddd, J = 8.1, 5.7, 1.2Hz, 1H), 7.4-7.7 (m, 6H), 6.75 (bs, 1H),
4.63 (d, J = 6.3Hz, 2H), 4.07 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H).
2-228 δ7.55-7.65 (m, 4H), 7.4-7.5 (m, 4H), 7.25-7.35 (m, 3H), 6.69 (bs, 1H),
6.48 (dd, J = 15.6, 2.4Hz, 1H), 4.61 (d, J = 6.0Hz, 2H),
4.00 (d, J = 17.3Hz, 1H), 3.61 (d, J = 17.3Hz, 1H).
2-229 δ7.4-7.75 (m, 5H), 6.59 (bs, 1H), 4.58 (d, J = 6.0Hz, 2H),
4.06 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H), 2.89 (s, 1H).
2-230 δ7.4-7.7 (m, 5H), 6.25 (bs, 1H), 4.55 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H), 2.95 (s, 3H).
2-231 δ7.6-7.7 (m, 3H), 7.4-7.6 (m, 2H), 6.30 (d, J = 6.0Hz, 1H),
4.54 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H),
2.4-2.6 (m, 4H), 1.99 (t, J = 1.8Hz, 1H).
2-232 δ7.85 (d, J = 1.8Hz, 1H), 7.62 (s, 2H), 7.55 (dd, J = 8.1, 1.8Hz, 1H),
7.48 (d, J = 8.1Hz, 1H), 6.18 (t, J = 6.2Hz, 1H), 4.54 (d, J = 6.2Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H), 2.4-2.65 (m, 4H),
2.0-2.05 (m, 1H).
2-233 δ8.27 (s, 1H), 7.91 (d, J = 7.8Hz, 1H), 7.76 (d, J = 7.8Hz, 1H),
7.63 (s, 2H), 6.62 (t, J = 6.0Hz, 1H), 4.72 (d, J = 6.0Hz, 2H),
4.11 (d, J = 17.4Hz, 1H), 3.74 (d, J = 17.4Hz, 1H), 2.35-2.6 (m, 4H),
1.98 (s, 1H).
2-234 δ7.65 (s, 2H), 7.60 (d, J = 8.7Hz, 2H), 7.40 (d, J = 8.7Hz, 2H),
6.00 (d, J = 7.5Hz, 1H), 5.05-5.2 (m, 1H), 4.05 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 2.35-2.6 (m, 4H), 2.00 (s, 1H),
1.50 (d, J = 7.2Hz, 3H).
2-235 δ7.72 (d, J = 8.4Hz, 2H), 7.63 (s, 2H), 7.55 (d, J = 8.4Hz, 2H),
6.38 (d, J = 8.7Hz, 1H), 6.23 (d, J = 8.7Hz, 1H), 4.08 (d, J = 17.4Hz, 1H),
3.68 (d, J = 17.4Hz, 1H), 2.45-2.65 (m, 4H), 2.0-2.05 (m, 1H).
2-236 δ7.63 (s, 2H), 7.58 (d, J = 8.7Hz, 2H), 7.28 (d, J = 8.7Hz, 2H),
7.25-7.3 (m, 1H), 6.75-6.9 (m, 2H), 5.80 (d, J = 7.5Hz, 1H),
5.05-5.15 (m, 1H), 4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H),
3.50 (s, 2H), 1.45 (d, J = 7.1Hz, 3H).
2-238 δ8.55 (d, J = 4.8Hz, 1H), 7.90 (d, J = 7.5Hz, 1H), 7.2-7.7 (m, 9H),
5.0-5.15 (m, 1H), 4.05 (d, J = 17.1Hz, 1H), 3.70 (d, J = 3.0Hz, 2H),
3.65 (d, J = 17.1Hz, 1H), 1.45 (d, J = 6.9Hz, 3H).
2-239 δ7.86 (s, 1H), 7.3-7.65 (m, 6H), 4.58 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
3.59 (sep, J = 6.9Hz, 1H), 1.14 (d, J = 6.9Hz, 6H).
2-240 δ8.07 (bs, 1H), 7.35-7.7 (m, 6H), 4.59 (d, J = 6.3Hz, 2H),
4.06 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H),
2.92 (dd, J = 5.1, 3.6Hz, 3H).
2-241 δ8.14 (bs, 1H), 7.35-7.7 (m, 6H), 4.59 (d, J = 6.3Hz, 2H),
4.06 (d, J = 17.3Hz, 1H), 3.66 (d, J = 17.3Hz, 1H),
2.36 (qui, J = 6.9Hz, 2H), 1.21 (t, J = 6.9Hz, 3H).
2-243 δ8.0-8.1 (m, 1H), 7.64 (d, J = 8.4Hz, 2H), 7.50 (d, J = 1.2Hz, 2H),
7.4-7.5 (m, 1H), 7.44 (d, J = 8.4Hz, 2H), 7.41 (t, J = 1.5Hz, 1H),
7.2-7.3 (m, 1H), 7.1-7.15 (m, 1H), 7.0-7.1 (m, 1H), 5.3-5.4 (m, 1H),
4.05 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H), 1.60 (d, J = 6.9Hz, 3H).
2-245 δ7.75-7.85 (m, 2H), 7.68 (s, 1H), 7.62 (s, 2H), 7.48 (s, 2H),
7.0-7.15 (m, 2H), 6.77 (bs, 1H), 4.70 (dd, J = 6.0, 1.5Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.68 (d, J = 17.3Hz, 1H).
2-246 δ7.87 (d, J = 1.2Hz, 1H), 7.78 (dd, J = 8.6, 5.4Hz, 2H), 7.62 (s, 2H),
7.57 (dd, J = 8.1, 1.2Hz, 1H), 7.52 (d, J = 8.1Hz, 1H),
7.11 (t, J = 8.6Hz, 2H), 6.64 (t, J = 6.0Hz, 1H), 4.71 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H).
2-248 δ7.25-7.75 (m, 9H), 6.87 (bs, 1H), 4.73 (d, J = 6.3Hz, 2H),
4.07 (d, J = 17.3Hz, 1H), 3.68 (d, J = 17.3Hz, 1H).
2-249 δ7.89 (s, 1H), 7.55-7.75 (m, 5H), 7.25-7.45 (m, 3H),
6.82 (t, J = 6.0Hz, 1H), 4.74 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.3Hz, 1H),
3.66 (d, J = 17.3Hz, 1H).
2-250 δ7.25-7.7 (m, 11H), 6.55 (d, J = 7.5Hz, 1H), 5.25-5.4 (m, 1H),
4.05 (d, J = 17.1Hz, 1H), 3.70 (d, J = 17.1Hz, 1H), 1.60 (d, J = 6.9Hz, 3H).
2-253 δ7.89 (d, J = 1.7Hz, 1H), 7.5-7.7 (m, 6H), 7.25-7.4 (m, 2H),
6.57 (t, J = 6.2Hz, 1H), 4.74 (d, J = 6.2Hz, 2H), 4.06 (d, J = 17.3Hz, 1H),
3.67 (d, J = 17.3Hz, 1H).
2-254 δ7.69 (d, J = 1.5Hz, 1H), 7.63 (s, 2H), 7.52 (t, J = 2.1Hz, 2H),
7.1-7.4 (m, 4H), 6.37 (bs, 1H), 4.69 (d, J = 6.0Hz, 2H),
4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 2.40 (s, 3H).
2-255 δ7.5-7.85 (m, 9H), 6.32 (bs, 1H), 4.72 (dd, J = 6.0, 1.8Hz, 2H),
4.07 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H).
2-256 δ7.2-7.95 (m, 10H), 6.6-6.65 (m, 1H), 4.75 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H).
2-257 δ7.0-7.75 (m, 15H), 6.5-6.6 (m, 1H), 4.70 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.1Hz, 1H), 3.65 (d, J = 17.1Hz, 1H).
2-258 δ7.5-7.7 (m, 6H), 7.15-7.45 (m, 3H), 7.04 (bs, 1H),
4.73 (t, J = 5.4Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
2.42 (s, 3H).
2-259 δ7.70 (s, 1H), 7.86 (d, J = 8.4Hz, 2H), 7.50 (d, J = 9.6Hz, 4H),
7.42 (t, J = 1.8Hz, 1H), 7.25 (d, J = 8.1Hz, 2H), 6.55-6.65 (m, 1H),
4.70 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.1Hz, 1H), 3.65 (d, J = 17.1Hz, 1H),
2.50 (s, 3H).
2-261 δ7.80 (d, J = 8.1Hz, 2H), 7.72 (s, 1H), 7.71 (d, J = 8.1Hz, 2H),
7.53 (d, J = 2.4Hz, 2H), 7.49 (s, 2H), 7.42 (t, J = 2.1Hz, 1H),
6.65 (t, J = 6.0Hz, 1H), 4.75 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.7Hz, 1H),
3.65 (d, J = 17.7Hz, 1H).
2-262 δ8.03 (d, J = 7.8Hz, 1H), 7.45-7.7 (m, 8H), 6.53 (bs, 1H),
4.70 (d, J = 6.0Hz, 2H), 4.07 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H).
2-263 δ7.26 (d, J = 8.4Hz, 2H), 7.94 (d, J = 8.4Hz, 2H), 7.70 (s, 1H),
7.63 (s, 2H), 7.52 (s, 2H), 6.97 (bs, 1H), 4.74 (d, J = 5.7Hz, 2H),
4.06 (d, J = 17.3Hz, 1H), 3.68 (d, J = 17.3Hz, 1H).
2-264 δ7.4-7.85 (m, 9H), 6.81 (bs, 1H), 4.78 (d, J = 6.0Hz, 2H),
4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H).
2-265 δ7.85-7.9 (m, 2H), 7.7-7.75 (m, 3H), 7.62 (s, 2H),
7.51 (d, J = 5.4Hz, 2H), 6.75-7.05 (m, 1H), 4.73 (dd, J = 6.0, 3.4Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H).
2-266 δ7.86 (d, J = 8.4Hz, 2H), 7.72 (d, J = 8.4Hz, 2H), 7.64 (d, J = 8.4Hz, 2H),
7.63 (s, 2H), 7.43 (d, J = 8.4Hz, 2H), 6.49 (d, J = 7.2Hz, 1H),
5.25-5.35 (m, 1H), 4.07 (d, J = 17.1Hz, 1H), 3.77 (d, J = 17.1Hz, 1H),
1.62 (d, J = 7.2Hz, 3H).
2-267 δ8.05-8.2 (m, 1H), 7.70 (s, 1H), 7.62 (s, 2H), 7.53 (s, 2H),
7.1-7.25 (m, 1H), 6.95-7.05 (m, 1H), 6.8-6.95 (m, 1H),
4.75 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H).
2-268 δ8.05-8.2 (m, 1H), 7.87 (d, J = 1.5Hz, 1H), 7.62 (s, 2H),
7.57 (dd, J = 7.8, 1.5Hz, 1H), 7.52 (d, J = 7.8Hz, 1H), 7.21 (bs, 1H),
6.8-7.05 (m, 2H), 4.73 (d, J = 6.2Hz, 2H), 4.05 (d, J = 17.6Hz, 1H),
3.65 (d, J = 17.6Hz, 1H).
2-269 δ8.31 (d, J = 1.8Hz, 1H), 8.0-8.15 (m, 1H), 7.96 (dd, J = 8.4, 1.8Hz, 1H),
7.83 (d, J = 8.4Hz, 1H), 7.45-7.55 (m, 3H), 7.43 (t, J = 1.8Hz, 1H),
6.95-7.05 (m, 1H), 6.8-6.95 (m, 1H), 4.93 (d, J = 5.1Hz, 2H),
4.06 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H).
2-270 δ8.31 (s, 1H), 7.8-8.15 (m, 3H), 7.63 (s, 2H), 7.45-7.7 (m, 1H),
6.8-7.05 (m, 2H), 4.92 (d, J = 6.6Hz, 2H), 4.11 (d, J = 17.4Hz, 1H),
3.73 (d, J = 17.4Hz, 1H).
2-271 δ8.05-8.15 (m, 1H), 7.65 (d, J = 8.1Hz, 2H), 7.51 (s, 2H),
7.4-7.45 (m, 3H), 6.85-7.0 (m, 3H), 5.25-5.35 (m, 1H),
4.05 (d, J = 17.1Hz, 1H), 3.70 (d, J = 17.1Hz, 1H), 1.60 (d, J = 6.9Hz, 3H).
2-272 δ8.05-8.15 (m, 1H), 7.64 (d, J = 8.7Hz, 2H), 7.63 (s, 2H),
7.44 (d, J = 8.7Hz, 2H), 6.8-7.05 (m, 3H), 5.25-5.35 (m, 1H),
4.07 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 1.59 (d, J = 7.2Hz, 3H).
2-273 δ8.1-8.25 (m, 1H), 7.75 (d, J = 8.4Hz, 2H), 7.63 (s, 2H),
7.62 (d, J = 8.4Hz, 2H), 7.1-7.2 (m, 1H), 7.0-7.1 (m, 1H),
6.85-6.95 (m, 1H), 6.39 (d, J = 6.6Hz, 1H), 4.09 (d, J = 17.4Hz, 1H),
3.69 (d, J = 17.4Hz, 1H).
2-274 δ7.25-7.7 (m, 7H), 6.8-6.95 (m, 3H), 4.67 (d, J = 6.0Hz, 2H),
4.06 (d, J = 17.3Hz, 1H), 3.66 (d, J = 17.3Hz, 1H).
2-275 δ7.7-7.8 (m, 3H), 7.40 (s, 2H), 7.3-7.4 (m, 1H), 6.85-7.0 (m, 2H),
6.76 (bs, 1H), 4.69 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.3Hz, 1H),
3.70 (d, J = 17.3Hz, 1H).
2-276 δ7.65 (d, J = 8.4Hz, 2H), 7.51 (d, J = 1.8Hz, 2H), 7.45 (d, J = 8.4Hz, 2H),
7.41 (t, J = 1.8Hz, 1H), 7.3-7.4 (m, 1H), 6.9-7.0 (m, 2H),
6.30 (d, J = 7.8Hz, 1H), 5.3-5.4 (m, 1H), 4.05 (d, J = 17.4Hz, 1H),
3.70 (d, J = 17.4Hz, 1H), 1.55 (d, J = 6.9Hz, 3H).
2-277 δ7.65 (s, 2H), 7.60 (d, J = 8.1Hz, 2H), 7.45 (d, J = 8.1Hz, 2H),
7.3-7.4 (m, 1H), 6.85-7.0 (m, 2H), 6.30 (d, J = 7.5Hz, 1H),
5.25-5.4 (m, 1H), 4.05 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H),
1.60 (d, J = 6.9Hz, 3H).
2-278 δ7.71 (s, 1H), 7.55-7.7 (m, 3H), 7.45-7.55 (m, 3H), 7.15-7.25 (m, 1H),
6.61 (t, J = 6.0Hz, 1H), 4.71 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H).
2-279 δ7.65-7.7 (m, 2H), 7.63 (s, 2H), 7.5-7.6 (m, 2H), 7.1-7.15 (m, 1H),
7.0-7.1 (m, 1H), 6.92 (t, J = 6.0Hz, 1H), 4.72 (t, J = 6.0Hz, 2H),
4.07 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H).
2-280 δ7.6-7.7 (m, 1H), 7.64 (d, J = 8.1Hz, 2H), 7.51 (d, J = 1.8Hz, 2H),
7.44 (d, J = 8.1Hz, 2H), 7.41 (t, J = 1.8Hz, 1H),
7.12 (dd, J = 8.4, 2.4Hz, 1H), 7.10 (td, J = 8.4, 2.4Hz, 1H),
6.60 (d, J = 7.5Hz, 1H), 5.25-5.35 (m, 1H), 4.10 (d, J = 17.4Hz, 1H),
3.70 (d, J = 17.4Hz, 1H), 1.60 (d, J = 7.2Hz, 3H).
2-281 δ7.71 (dd, J = 9.0, 6.3Hz, 1H), 7.65 (d, J = 7.8Hz, 2H), 7.64 (s, 2H),
7.46 (d, J = 7.8Hz, 2H), 7.15 (dd, J = 8.4, 2.7Hz, 1H),
7.05 (td, J = 8.1, 2.7Hz, 1H), 6.82 (d, J = 7.2Hz, 1H), 5.25-5.35 (m, 1H),
4.07 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 1.61 (d, J = 7.2Hz, 3H).
2-282 δ8.12 (t, J = 7.8Hz, 1H), 7.4-7.55 (m, 8H), 4.76 (d, J = 5.7Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H).
2-283 δ8.16 (t, J = 7.8Hz, 1H), 7.65 (d, J = 8.4Hz, 2H), 7.58 (d, J = 4.5Hz, 1H),
7.50 (s, 2H), 7.4-7.45 (m, 4H), 6.97 (dd, J = 10.5, 7.8Hz, 1H),
5.25-5.4 (m, 1H), 4.08 (d, J = 17.1Hz, 1H), 3.68 (d, J = 17.1Hz, 1H),
1.61 (d, J = 6.9Hz, 3H).
2-284 δ7.72 (s, 1H), 7.55 (d, J = 1.8Hz, 2H), 7.49 (s, 2H),
7.42 (t, J = 1.8Hz, 1H), 6.7-6.8 (m, 2H), 6.35-6.45 (m, 1H),
4.75 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H).
2-286 δ7.70 (s, 1H), 7.65 (s, 2H), 7.55 (s, 2H), 6.65-6.75 (m, 2H),
6.55 (t, J = 6.0Hz, 1H), 4.70 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H).
2-288 δ7.66 (d, J = 8.1Hz, 2H), 7.51 (d, J = 2.1Hz, 2H), 7.4-7.45 (m, 3H),
6.65-6.75 (m, 2H), 6.20 (d, J = 7.8Hz, 1H), 5.3-5.4 (m, 1H),
4.10 (d, J = 17.1Hz, 1H), 3.70 (d, J = 17.1Hz, 1H), 1.60 (d, J = 6.9Hz, 3H).
2-289 δ8.08 (s, 2H), 7.95 (s, 1H), 7.67 (d, J = 8.7Hz, 2H),
7.45 (d, J = 8.7Hz, 2H), 6.72 (t, J = 8.4Hz, 2H), 6.16 (d, J = 7.2Hz, 1H),
5.25-5.4 (m, 1H), 4.19 (d, J = 17.4Hz, 1H), 3.73 (d, J = 17.4Hz, 1H),
1.59 (d, J = 6.9Hz, 3H).
2-290 δ7.65 (s, 2H), 7.60 (d, J = 8.4Hz, 2H), 7.40 (d, J = 8.4Hz, 2H),
6.65-6.75 (m, 2H), 6.25 (d, J = 6.6Hz, 1H), 5.25-5.35 (m, 1H),
4.05 (d, J = 17.7Hz, 1H), 3.70 (d, J = 17.7Hz, 1H), 1.60 (d, J = 7.2Hz, 3H).
2-291 δ7.65 (d, J = 8.4Hz, 2H), 7.64 (s, 2H), 7.40 (d, J = 8.4Hz, 2H),
6.40 (d, J = 7.8Hz, 1H), 5.25-5.35 (m, 1H), 4.10 (d, J = 17.4Hz, 1H),
3.70 (d, J = 17.4Hz, 1H), 1.60 (d, J = 6.6Hz, 3H).
2-292 δ7.63 (d, J = 8.4Hz, 2H), 7.51 (d, J = 1.5Hz, 2H), 7.4-7.45 (m, 3H),
7.05 (d, J = 3.6Hz, 1H), 6.55 (d, J = 7.5Hz, 1H), 6.45 (d, J = 3.6Hz, 1H),
5.2-5.3 (m, 1H), 4.05 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H),
1.60 (d, J = 7.2Hz, 3H).
2-293 δ7.08 (s, 1H), 7.45-7.6 (m, 7H), 7.06 (dd, J = 4.5, 4.2Hz, 1H),
6.67 (d, J = 6.0Hz, 1H), 4.68 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.3Hz, 1H),
3.66 (d, J = 17.3Hz, 1H).
2-294 δ7.65-7.7 (m, 1H), 7.62 (s, 2H), 7.4-7.6 (m, 4H), 6.97 (d, J = 5.1Hz, 1H),
4.74 (d, J = 6.6Hz, 2H), 4.05 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H).
2-295 δ7.64 (d, J = 8.7Hz, 2H), 7.50 (d, J = 1.8Hz, 2H), 7.46 (d, J = 5.1Hz, 1H),
7.44 (d, J = 8.7Hz, 2H), 7.41 (t, J = 1.8Hz, 1H), 7.25 (d, J = 7.2Hz, 1H),
7.00 (d, J = 5.1Hz, 1H), 5.2-5.35 (m, 1H), 4.05 (d, J = 17.1Hz, 1H),
3.65 (d, J = 17.1Hz, 1H), 1.60 (d, J = 7.2Hz, 3H).
2-296 δ7.92 (d, J = 1.5Hz, 1H), 7.69 (d, J = 1.2Hz, 1H), 7.63 (s, 2H),
7.45-7.55 (m, 2H), 6.76 (t, J = 6.3Hz, 1H), 4.68 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.87 (s, 3H), 3.67 (d, J = 17.4Hz, 1H).
2-299 δ7.71 (d, J = 1.5Hz, 1H), 7.63 (s, 2H), 7.45-7.55 (m, 2H), 6.55 (bs, 1H),
6.44 (d, J = 1.2Hz, 1H), 4.66 (d, J = 6.3Hz, 2H), 4.09 (s, 3H),
4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H).
2-301 δ8.75 (d, J = 2.1Hz, 1H), 8.15 (d, J = 2.1Hz, 1H), 7.6-7.65 (m, 5H),
7.45 (d, J = 8.1Hz, 2H), 5.25-5.35 (m, 1H), 4.05 (d, J = 17.1Hz, 1H),
3.65 (d, J = 17.1Hz, 1H), 1.60 (d, J = 7.2Hz, 3H).
2-302 δ8.10 (s, 1H), 7.73 (s, 1H), 7.62 (s, 2H), 7.54 (d, J = 1.2Hz, 2H),
7.32 (t, J = 1.2Hz, 1H), 7.08 (s, 1H), 6.44 (bs, 1H),
4.70 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H).
2-304 δ8.4-8.45 (m, 1H), 8.05-8.15 (m, 1H), 7.5-7.7 (m, 5H),
7.25-7.35 (m, 1H), 7.18 (bs, 1H), 4.74 (d, J = 6.3Hz, 2H),
4.07 (d, J = 17.3Hz, 1H), 3.69 (d, J = 17.3Hz, 1H).
2-305 δ8.47 (dd, J = 4.8, 2.1Hz, 1H), 8.15 (dd, J = 7.8, 2.1Hz, 1H), 7.89 (s, 1H),
7.55-7.7 (m, 4H), 7.35 (dd, J = 7.8, 4.8Hz, 1H), 7.15 (t, J = 5.9Hz, 1H),
4.75 (d, J = 6.2Hz, 2H), 4.06 (d, J = 17.5Hz, 1H), 3.67 (d, J = 17.5Hz, 1H).
2-306 δ7.7-7.85 (m, 4H), 7.63 (d, J = 8.4Hz, 2H), 7.55 (d, J = 8.4Hz, 2H),
7.49 (s, 2H), 7.41 (t, J = 1.8Hz, 1H), 5.55-5.65 (m, 1H),
4.05 (d, J = 17.1Hz, 1H), 3.65 (d, J = 17.1Hz, 1H), 1.90 (d, J = 7.5Hz, 3H).
2-307 δ8.46 (dd, J = 4.8, 1.8Hz, 1H), 8.11 (dd, J = 7.8, 1.8Hz, 1H),
7.66 (d, J = 8.7Hz, 2H), 7.64 (s, 2H), 7.47 (d, J = 8.7Hz, 2H),
7.35 (dd, J = 7.8, 1.8Hz, 1H), 6.83 (d, J = 7.5Hz, 1H), 5.25-5.4 (m, 1H),
4.08 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H), 1.62 (d, J = 6.9Hz, 3H).
2-308 δ8.06 (dd, J = 8.0, 2.3Hz, 1H), 7.68 (s, 1H), 7.35-7.6 (m, 7H),
6.98 (bs, 1H), 4.71 (d, J = 6.0Hz, 2H), 4.51 (d, J = 17.3Hz, 1H),
3.68 (d, J = 17.3Hz, 1H).
2-309 δ8.0-8.1 (m, 1H), 7.35-7.75 (m, 7H), 6.92 (t, J = 6.0Hz, 1H),
4.72 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H).
2-310 δ8.73 (d, J = 2.4Hz, 1H), 8.06 (dd, J = 8.1, 2.4Hz, 1H),
7.85 (d, J = 1.8Hz, 1H), 7.62 (s, 2H), 7.56 (dd, J = 8.1, 1.8Hz, 1H),
7.48 (d, J = 8.1Hz, 1H), 7.39 (d, J = 8.1Hz, 1H), 6.93 (t, J = 5.7Hz, 1H),
4.69 (d, J = 5.7Hz, 2H), 4.05 (d, J = 17.2Hz, 1H), 3.67 (d, J = 17.2Hz, 1H).
2-312 δ8.90 (d, J = 4.8Hz, 2H), 8.30 (d, J = 5.4Hz, 1H), 7.63 (s, 2H),
7.62 (d, J = 8.1Hz, 2H), 7.47 (d, J = 8.1Hz, 2H), 7.46 (t, J = 4.8Hz, 1H),
5.35-5.45 (m, 1H), 4.05 (d, J = 17.1Hz, 1H), 3.65 (d, J = 17.1Hz, 1H),
1.65 (d, J = 7.2Hz, 3H).
2-313 δ9.40 (d, J = 1.5Hz, 1H), 8.77 (d, J = 2.4Hz, 1H),
8.53 (dd, J = 2.4, 1.5Hz, 1H), 8.25-8.3 (m, 1H), 7.71 (s, 1H),
7.53 (d, J = 1.5Hz, 2H), 7.48 (s, 2H), 7.42 (t, J = 1.8Hz, 1H),
4.80 (d, J = 6.3Hz, 2H), 4.10 (d, J = 17.1Hz, 1H), 3.65 (d, J = 17.1Hz, 1H).
2-314 δ8.07 (s, 2H), 7.96 (s, 1H), 7.86 (d, J = 1.5Hz, 1H),
7.56 (dd, J = 7.8, 1.5Hz, 1H), 7.44 (d, J = 7.8Hz, 1H),
6.02 (t, J = 6.3Hz, 1H), 4.51 (d, J = 6.3Hz, 2H), 4.16 (d, J = 17.4Hz, 1H),
3.72 (d, J = 17.4Hz, 1H), 2.26 (q, J = 7.5Hz, 2H), 1.17 (t, J = 7.5Hz, 3H).
2-315 δ8.07 (s, 2H), 7.95 (s, 1H), 7.63 (d, J = 8.1Hz, 2H),
7.37 (d, J = 8.1Hz, 2H), 5.65 (d, J = 7.8Hz, 1H), 5.05-5.2 (m, 1H),
4.17 (d, J = 17.5Hz, 1H), 3.72 (d, J = 17.5Hz, 1H), 2.22 (q, J = 7.8Hz, 2H),
1.48 (d, J = 6.9Hz, 3H), 1.15 (t, J = 7.8Hz, 3H).
2-316 δ7.91 (d, J = 1.5Hz, 1H), 7.73 (dd, J = 8.4, 1.5Hz, 1H),
7.66 (d, J = 1.5Hz, 1H), 7.61 (d, J = 8.4Hz, 1H),
7.49 (dd, J = 8.1, 1.5Hz, 1H), 7.41 (d, J = 8.1Hz, 1H), 6.22 (bs, 1H),
4.50 (d, J = 6.0Hz, 2H), 4.11 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H),
2.21 (t, J = 6.9Hz, 2H), 1.6-1.75 (m, 2H), 0.93 (t, J = 6.9Hz, 3H).
2-317 δ8.06 (s, 2H), 7.96 (s, 1H), 7.87 (d, J = 1.8Hz, 1H),
7.57 (dd, J = 7.8, 1.5Hz, 1H), 7.46 (d, J = 7.8Hz, 1H),
5.94 (t, J = 5.8Hz, 1H), 4.52 (d, J = 6.0Hz, 2H), 4.16 (d, J = 17.4Hz, 1H),
3.71 (d, J = 17.4Hz, 1H), 2.20 (t, J = 7.2Hz, 2H), 1.6-1.75 (m, 2H),
0.94 (t, J = 7.2Hz, 3H).
2-318 δ8.07 (s, 2H), 7.95 (s, 1H), 7.63 (d, J = 8.1Hz, 2H),
7.37 (d, J = 8.1Hz, 2H), 5.64 (d, J = 7.5Hz, 1H), 5.1-5.2 (m, 1H),
4.18 (d, J = 17.1Hz, 1H), 3.72 (d, J = 17.1Hz, 1H), 2.17 (t, J = 7.8Hz, 2H),
1.6-1.7 (m, 2H), 1.48 (d, J = 6.9Hz, 3H), 0.93 (t, J = 7.5Hz, 3H).
2-319 δ8.07 (s, 2H), 7.96 (s, 1H), 7.87 (d, J = 1.5Hz, 1H),
7.57 (dd, J = 7.8, 1.5Hz, 1H), 7.44 (d, J = 7.8Hz, 1H),
6.00 (t, J = 6.9Hz, 1H), 4.50 (d, J = 6.3Hz, 2H), 4.16 (d, J = 17.4Hz, 1H),
3.71 (d, J = 17.4Hz, 1H), 2.35-2.45 (m, 1H), 1.17 (d, J = 6.6Hz, 6H).
2-320 δ8.09 (s, 2H), 7.97 (s, 1H), 7.65 (d, J = 7.8Hz, 2H),
7.37 (d, J = 7.8Hz, 2H), 5.65 (d, J = 7.2Hz, 1H), 5.05-5.2 (m, 1H),
4.19 (d, J = 17.1Hz, 1H), 3.74 (d, J = 17.1Hz, 1H), 2.3-2.45 (m, 1H),
1.49 (d, J = 6.9Hz, 3H), 1.16 (t, J = 7.5Hz, 6H).
2-321 δ7.91 (d, J = 1.5Hz, 1H), 7.73 (dd, J = 8.4, 1.5Hz, 1H),
7.70 (d, J = 1.5Hz, 1H), 7.61 (d, J = 8.4Hz, 1H),
7.51 (dd, J = 8.1, 1.5Hz, 1H), 7.47 (d, J = 8.1Hz, 1H), 6.09 (bs, 1H),
4.56 (d, J = 6.3Hz, 2H), 4.10 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H),
1.3-1.45 (m, 1H), 0.95-1.05 (m, 2H), 0.7-0.85 (m, 2H).
2-322 δ8.07 (s, 2H), 7.97 (s, 1H), 7.88 (d, J = 1.8Hz, 1H),
7.58 (dd, J = 8.1, 1.8Hz, 1H), 7.47 (d, J = 8.1Hz, 1H),
6.14 (t, J = 6.3Hz, 1H), 4.54 (d, J = 6.0Hz, 2H), 4.16 (d, J = 17.4Hz, 1H),
3.72 (d, J = 17.4Hz, 1H), 1.35-1.45 (m, 1H), 0.95-1.05 (m, 2H),
0.75-0.8 (m, 2H).
2-324 δ7.90 (d, J = 1.5Hz, 1H), 7.74 (dd, J = 8.4, 1.5Hz, 1H),
7.70 (d, J = 1.5Hz, 1H), 7.61 (d, J = 8.4Hz, 1H),
7.52 (dd, J = 8.1, 1.5Hz, 1H), 7.47 (d, J = 8.1Hz, 1H),
6.46 (t, J = 6.0Hz, 1H), 4.56 (d, J = 6.0Hz, 2H), 4.10 (d, J = 17.4Hz, 1H),
3.68 (d, J = 17.4Hz, 1H), 2.20 (d, J = 7.2Hz, 2H), 0.9-1.05 (m, 1H),
0.55-0.7 (m, 2H), 0.15-0.25 (m, 2H).
2-325 δ7.70 (d, J = 1.5Hz, 1H), 7.64 (s, 2H), 7.51 (dd, J = 7.8, 1.5Hz, 1H),
7.47 (d, J = 7.8Hz, 1H), 6.61 (t, J = 73.5Hz, 1H), 6.45 (bs, 1H),
4.57 (d, J = 6.0Hz, 2H), 4.07 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
2.20 (d, J = 7.2Hz, 2H), 0.9-1.05 (m, 1H), 0.55-0.7 (m, 2H),
0.15-0.25 (m, 2H).
2-326 δ8.07 (s, 2H), 7.97 (s, 1H), 7.89 (d, J = 1.8Hz, 1H),
7.58 (dd, J = 8.1, 1.8Hz, 1H), 7.47 (d, J = 8.1Hz, 1H),
6.49 (t, J = 6.0Hz, 1H), 4.55 (d, J = 6.3Hz, 2H), 4.16 (d, J = 17.4Hz, 1H),
3.71 (d, J = 17.4Hz, 1H), 2.20 (d, J = 7.2Hz, 2H), 0.95-1.0 (m, 1H),
0.6-0.7 (m, 2H), 0.15-0.25 (m, 2H).
2-328 δ7.90 (d, J = 1.5Hz, 1H), 7.72 (dd, J = 8.4, 1.5Hz, 1H),
7.65 (d, J = 1.5Hz, 1H), 7.60 (d, J = 8.4Hz, 1H),
7.47 (dd, J = 8.1, 1.5Hz, 1H), 7.35 (d, J = 8.1Hz, 1H),
6.69 (t, J = 6.3Hz, 1H), 4.52 (d, J = 6.3Hz, 2H), 4.10 (d, J = 17.4Hz, 1H),
3.69 (d, J = 17.4Hz, 1H), 3.11 (q, J = 10.5Hz, 2H).
2-329 δ7.91 (d, J = 1.5Hz, 1H), 7.73 (dd, J = 8.4, 1.5Hz, 1H),
7.69 (d, J = 1.5Hz, 1H), 7.61 (d, J = 8.4Hz, 1H),
7.51 (dd, J = 8.1, 1.5Hz, 1H), 7.43 (d, J = 8.1Hz, 1H), 6.28 (bs, 1H),
4.46 (d, J = 6.0Hz, 2H), 4.10 (d, J = 17.4Hz, 1H), 3.75-4.0 (m, 4H),
3.68 (d, J = 17.4Hz, 1H), 2.85-3.0 (m, 1H), 2.1-2.25 (m, 2H).
2-330 δ8.07 (s, 2H), 7.97 (s, 1H), 7.89 (d, J = 1.5Hz, 1H),
7.59 (dd, J = 8.1, 1.8Hz, 1H), 7.45 (d, J = 8.1Hz, 1H),
6.25 (t, J = 6.6Hz, 1H), 4.51 (d, J = 6.0Hz, 2H), 4.16 (d, J = 17.1Hz, 1H),
3.75-4.0 (m, 4H), 3.71 (d, J = 17.1Hz, 1H), 2.9-3.0 (m, 1H),
2.1-2.2 (m, 2H).
2-331 δ8.07 (s, 2H), 7.96 (s, 1H), 7.64 (d, J = 8.1Hz, 2H),
7.37 and 7.35 (d, J = 8.1Hz, 2H), 5.90 (d, J = 7.5Hz, 1H),
5.05-5.15 (m, 1H), 4.18 (d, J = 17.4Hz, 1H), 3.75-4.0 (m, 4H),
3.72 (d, J = 17.4Hz, 1H), 2.85-2.95 (m, 1H), 2.1-2.2 (m, 2H),
1.49 and 1.48 (d, J = 6.9Hz, 3H).
2-332 δ7.94 (t, J = 6.0Hz, 1H), 7.74 (d, J = 1.2Hz, 1H), 7.63 (s, 2H),
7.4-7.55 (m, 2H), 4.56 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.4Hz, 1H),
3.67 (d, J = 17.4Hz, 1H), 3.36 (s, 2H), 2.47 (d, J = 6.9Hz, 2H),
2.46 (bs, 1H), 0.85-1.0 (m, 1H), 0.4-0.5 (m, 2H), 0.05-0.15 (m, 2H).
2-334 δ7.70 (d, J = 1.5Hz, 1H), 7.63 (s, 2H), 7.4-7.55 (m, 2H), 6.41 (bs, 1H),
4.55 (d, J = 6.0Hz, 2H), 4.06 (s, 2H), 4.06 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 3.26 (t, J = 1.5Hz, 3H).
2-335 δ7.68 (s, 2H), 7.64 (s, 1H), 7.4-7.6 (m, 2H), 6.74 (bs, 1H),
4.53 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.93 (s, 2H),
3.68 (d, J = 17.4Hz, 1H), 3.42 (d, J = 6.9Hz, 2H), 0.95-1.05 (m, 1H),
0.55-0.65 (m, 2H), 0.25-0.35 (m, 2H).
2-336 δ7.7-7.75 (m, 1H), 7.63 (s, 2H), 7.4-7.55 (m, 2H),
6.34 and 6.17 (t, J = 6.3Hz, 1H), 4.59 and 4.55 (d, J = 6.3Hz, 2H),
4.39 and 4.37 (t, J = 2.4Hz, 2H), 4.27 and 4.19 (s, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H),
2.35 and 2.31 (t, J = 2.4Hz, 1H).
2-337 δ7.67 (s, 1H), 7.64 (s, 2H), 7.4-7.55 (m, 2H), 6.89 (bs, 1H),
4.55 (d, J = 6.3Hz, 2H), 4.07 (d, J = 17.4Hz, 1H), 4.05 (s, 2H),
3.73 (s, 3H), 3.68 (d, J = 17.4Hz, 1H), 3.23 (d, J = 7.2Hz, 2H),
0.9-1.05 (m, 1H), 0.45-0.55 (m, 2H), 0.2-0.3 (m, 2H).
2-338 δ7.68 (d, J = 1.5Hz, 1H), 7.63 (s, 2H), 7.4-7.55 (m, 2H), 6.40 (bs, 1H),
4.56 (d, J = 6.3Hz, 2H), 4.19 (s, 2H), 4.06 (d, J = 17.4Hz, 1H),
4.05 (s, 2H), 3.76 (s, 3H), 3.66 (d, J = 17.4Hz, 1H),
2.24 (t, J = 2.4Hz, 1H).
2-339 δ7.69 (d, J = 1.5Hz, 1H), 7.63 (s, 2H), 7.4-7.5 (m, 2H),
4.56 (d, J = 6.3Hz, 2H), 4.16 (q, J = 6.9Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.94 (s, 2H), 3.65 (d, J = 17.4Hz, 1H), 2.99 (s, 3H),
1.25 (t, J = 6.9Hz, 3H).
2-340 δ7.65 (d, J = 1.2Hz, 1H), 7.63 (s, 2H), 7.4-7.55 (m, 2H),
7.16 (t, J = 6.3Hz, 1H), 4.59 (t, J = 5.4Hz, 1H), 4.52 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.96 (s, 2H), 3.66 (d, J = 17.4Hz, 1H),
3.27 (qd, J = 7.2, 5.4Hz, 2H), 2.95 (s, 3H), 1.15 (t, J = 7.2Hz, 3H).
2-341 δ7.80 (t, J = 6.0Hz, 1H), 7.6-7.7 (m, 3H), 7.45-7.55 (m, 1H),
7.35-7.45 (m, 1H), 6.89 (bs, 1H), 4.54 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 3.22 (s, 2H),
3.21 (q, J = 7.2Hz, 2H), 1.53 (sxt, J = 7.2Hz, 2H), 0.91 (t, J = 7.2Hz, 3H).
2-342 δ8.07 (s, 2H), 7.96 (s, 1H), 7.68 (s, 1H), 7.4-7.55 (m, 2H),
6.31 (bs, 1H), 4.54 (d, J = 6.0Hz, 2H), 4.17 (d, J = 17.4Hz, 1H),
3.73 (d, J = 17.4Hz, 1H), 2.4-2.6 (m, 4H), 2.00 (t, J = 2.4Hz, 1H).
2-343 δ8.07 (s, 2H), 7.97 (s, 1H), 7.88 (d, J = 1.8Hz, 1H),
7.58 (dd, J = 8.1, 1.8Hz, 1H), 7.49 (d, J = 8.1Hz, 1H),
6.16 (t, J = 6.0Hz, 1H), 4.55 (d, J = 6.3Hz, 2H), 4.16 (d, J = 17.4Hz, 1H),
3.71 (d, J = 17.4Hz, 1H), 2.5-2.6 (m, 2H), 2.4-2.5 (m, 2H),
2.00 (t, J = 2.4Hz, 1H).
2-344 δ8.07 (s, 2H), 7.95 (s, 1H), 7.63 (d, J = 8.4Hz, 2H),
7.39 (d, J = 8.4Hz, 2H), 5.89 (d, J = 7.5Hz, 1H), 5.1-5.2 (m, 1H),
4.18 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H), 2.5-2.55 (m, 2H),
2.35-2.45 (m, 2H), 2.01 (bs, 1H), 1.50 (d, J = 6.9Hz, 3H).
2-346 δ7.64 (d, J = 8.4Hz, 2H), 7.51 (s, 2H), 7.42 (t, J = 1.8Hz, 1H),
7.36 (d, J = 8.4Hz, 2H), 6.33 (d, J = 6.3Hz, 1H), 5.05-5.15 (m, 1H),
4.07 (d, J = 17.1Hz, 1H), 3.68 (d, J = 17.1Hz, 1H), 1.53 (d, J = 6.9Hz, 3H),
1.35-1.45 (m, 2H), 1.15-1.25 (m, 2H).
2-348 δ7.95 (s, 1H), 7.84 (s, 1H), 7.79 (s, 1H), 7.69 (d, J = 1.8Hz, 1H),
7.51 (dd, J = 8.4, 1.8Hz, 1H), 7.44 (d, J = 8.4Hz, 1H),
5.96 (t, J = 6.2Hz, 1H), 4.53 (d, J = 6.2Hz, 2H), 4.10 (d, J = 17.5Hz, 1H),
3.69 (d, J = 17.5Hz, 1H), 2.04 (s, 3H).
2-350 δ7.75 (d, J = 5.7Hz, 2H), 7.66 (s, 1H), 7.35-7.5 (m, 2H), 6.13 (bs, 1H),
4.51 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
2.04 (s, 3H).
2-351 δ7.83 (s, 2H), 7.69 (d, J = 1.2Hz, 1H), 7.45-7.55 (m, 2H),
5.94 (t, J = 6.0Hz, 1H), 4.54 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 2.04 (s, 3H).
2-352 δ7.87 (s, 1H), 7.80 (s, 1H), 7.75 (s, 1H), 7.69 (s, 1H),
7.58 (d, J = 8.1Hz, 1H), 7.47 (d, J = 8.1Hz, 1H), 5.96 (bs, 1H),
4.51 (d, J = 6.3Hz, 2H), 4.10 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H),
2.04 (s, 3H).
2-354 δ7.75 (d, J = 5.4Hz, 2H), 7.67 (s, 1H), 7.4-7.55 (m, 2H), 5.99 (bs, 1H),
4.52 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H),
2.03 (s, 3H).
2-355 δ8.10 (d, J = 1.8Hz, 1H), 7.75 (d, J = 5.7Hz, 2H),
7.60 (dd, J = 7.8, 1.8Hz, 1H), 7.42 (d, J = 7.8Hz, 1H),
5.94 (t, J = 6.0Hz, 1H), 4.47 (d, J = 6.0Hz, 2H), 4.03 (d, J = 17.4Hz, 1H),
3.64 (d, J = 17.4Hz, 1H), 2.40 (s, 3H).
2-356 δ8.31 (bs, 1H), 8.08 (s, 2H), 7.9-8.05 (m, 2H), 7.78 (d, J = 8.1Hz, 1H),
6.2-6.35 (m, 1H), 4.72 (d, J = 6.6Hz, 2H), 4.21 (d, J = 17.4Hz, 1H),
3.76 (d, J = 17.4Hz, 1H), 2.00 (s, 3H).
2-360 δ8.07 (s, 2H), 7.97 (s, 1H), 7.3-7.55 (m, 3H), 6.03 (bs, 1H),
4.49 (d, J = 6.0Hz, 2H), 4.16 (d, J = 17.4Hz, 1H), 3.73 (d, J = 17.4Hz, 1H),
2.25 (q, J = 7.5Hz, 2H), 1.16 (t, J = 7.5Hz, 3H).
2-362 δ7.95 (s, 1H), 7.84 (s, 1H), 7.79 (s, 1H), 7.69 (d, J = 1.5Hz, 1H),
7.51 (dd, J = 8.1, 1.5Hz, 1H), 7.46 (d, J = 8.1Hz, 1H),
5.93 (t, J = 6.3Hz, 1H), 4.53 (d, J = 6.3Hz, 2H), 4.10 (d, J = 17.4Hz, 1H),
3.69 (d, J = 17.4Hz, 1H), 2.25 (q, J = 7.6Hz, 2H), 1.17 (t, J = 7.6Hz, 3H).
2-364 δ7.75 (d, J = 6.0Hz, 2H), 7.66 (d, J = 1.2Hz, 1H), 7.4-7.55 (m, 2H),
5.95-6.15 (m, 1H), 4.52 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 2.26 (q, J = 7.5Hz, 2H), 1.19 (t, J = 7.5Hz, 3H).
2-365 δ7.83 (s, 2H), 7.69 (d, J = 1.5Hz, 1H), 7.45-7.55 (m, 2H),
5.91 (t, J = 6.0Hz, 1H), 4.54 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 2.26 (q, J = 7.5Hz, 2H), 1.17 (t, J = 7.5Hz, 3H).
2-366 δ7.93 (d, J = 1.8Hz, 1H), 7.82 (s, 1H), 7.68 (d, J = 1.5Hz, 1H),
7.4-7.55 (m, 2H), 5.60 (t, J = 6.0Hz, 1H), 4.53 (d, J = 6.0Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H), 2.26 (q, J = 7.8Hz, 2H),
1.17 (t, J = 7.8Hz, 3H).
2-368 δ7.87 (s, 1H), 7.80 (s, 1H), 7.75 (s, 1H), 7.69 (s, 1H),
7.58 (d, J = 8.1Hz, 1H), 7.47 (d, J = 8.1Hz, 1H), 5.92 (bs, 1H),
4.52 (d, J = 6.0Hz, 2H), 4.10 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H),
2.26 (q, J = 7.5Hz, 2H), 1.17 (t, J = 7.5Hz, 3H).
2-369 δ7.96 (s, 1H), 7.88 (s, 1H), 7.84 (s, 1H), 7.80 (s, 1H),
7.58 (d, J = 8.1Hz, 1H), 7.47 (d, J = 8.1Hz, 1H), 5.94 (bs, 1H),
4.52 (d, J = 6.3Hz, 2H), 4.10 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H),
2.26 (q, J = 7.5Hz, 2H), 1.17 (t, J = 7.5Hz, 3H).
2-370 δ7.75 (d, J = 5.4Hz, 2H), 7.67 (d, J = 1.5Hz, 1H), 7.4-7.55 (m, 2H),
5.99 (bs, 1H), 4.53 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 2.26 (q, J = 7.5Hz, 2H), 1.17 (t, J = 7.5Hz, 3H).
2-371 δ7.94 (s, 1H), 7.87 (s, 1H), 7.83 (s, 1H), 7.58 (d, J = 8.1Hz, 1H),
7.47 (d, J = 8.1Hz, 1H), 5.93 (bs, 1H), 4.52 (d, J = 6.0Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 2.27 (q, J = 7.5Hz, 2H),
1.17 (t, J = 7.5Hz, 3H).
2-373 δ8.10 (d, J = 1.8Hz, 1H), 7.75 (d, J = 5.7Hz, 2H),
7.60 (dd, J = 7.8, 1.8Hz, 1H), 7.42 (d, J = 7.8Hz, 1H),
5.93 (t, J = 6.0Hz, 1H), 4.47 (d, J = 6.0Hz, 2H), 4.03 (d, J = 17.4Hz, 1H),
3.64 (d, J = 17.4Hz, 1H), 2.27 (q, J = 7.5Hz, 2H), 1.18 (t, J = 7.5Hz, 3H).
2-376 δ7.97 (s, 1H), 7.84 (s, 1H), 7.80 (s, 1H), 7.64 (d, J = 8.1Hz, 2H),
7.38 (d, J = 8.1Hz, 2H), 5.63 (d, J = 7.2Hz, 1H), 5.14 (qui, J = 7.2Hz, 1H),
4.12 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H), 2.22 (q, J = 7.5Hz, 2H),
1.48 (d, J = 7.2Hz, 3H), 1.15 (t, J = 7.5Hz, 3H).
2-378 δ8.07 (s, 2H), 7.95 (s, 1H), 7.63 (d, J = 8.1Hz, 2H),
7.37 (d, J = 8.1Hz, 2H), 5.65 (d, J = 7.8Hz, 1H), 5.05-5.2 (m, 1H),
4.17 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H), 2.22 (q, J = 7.8Hz, 2H),
1.48 (d, J = 6.9Hz, 3H), 1.15 (t, J = 7.8Hz, 3H).
2-380 δ8.08 (s, 2H), 7.98 (s, 1H), 7.75 (d, J = 8.4Hz, 2H),
7.56 (d, J = 8.4Hz, 2H), 6.26 (d, J = 8.4Hz, 1H), 5.99 (d, J = 8.4Hz, 1H),
4.20 (d, J = 17.4Hz, 1H), 3.76 (d, J = 17.4Hz, 1H), 2.32 (q, J = 7.5Hz, 2H),
1.21 (t, J = 7.5Hz, 3H).
2-383 δ7.64 (d, J = 8.4Hz, 1H), 7.45-7.6 (m, 4H), 7.4-7.45 (m, 1H),
6.19 (s, 2H), 4.07 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H),
2.36 (s, 3H), 2.2-2.35 (m, 2H), 1.17 (t, J = 7.8Hz, 3H).
2-384 δ8.07 (s, 2H), 7.96 (s, 1H), 7.3-7.45 (m, 3H), 6.10 (bs, 1H),
4.49 (d, J = 6.0Hz, 2H), 4.17 (d, J = 17.4Hz, 1H), 3.73 (d, J = 17.4Hz, 1H),
2.20 (t, J = 7.5Hz, 2H), 1.66 (sxt, J = 7.5Hz, 2H), 0.93 (t, J = 7.5Hz, 3H).
2-385 δ7.86 (s, 1H), 7.82 (d, J = 7.8Hz, 1H), 7.65-7.75 (m, 2H),
7.59 (t, J = 7.8Hz, 1H), 7.45-7.55 (m, 2H), 5.93 (t, J = 6.2Hz, 1H),
4.53 (d, J = 6.2Hz, 2H), 4.10 (d, J = 17.2Hz, 1H), 3.71 (d, J = 17.2Hz, 1H),
2.20 (t, J = 7.6Hz, 2H), 1.55-1.75 (m, 2H), 0.94 (t, J = 7.4Hz, 3H).
2-386 δ7.95 (s, 1H), 7.83 (s, 1H), 7.79 (s, 1H), 7.69 (d, J = 1.8Hz, 1H),
7.51 (dd, J = 8.1, 1.8Hz, 1H), 7.46 (d, J = 8.1Hz, 1H),
5.92 (t, J = 6.0Hz, 1H), 4.53 (d, J = 6.0Hz, 2H), 4.10 (d, J = 17.4Hz, 1H),
3.69 (d, J = 17.4Hz, 1H), 2.20 (t, J = 7.7Hz, 2H), 1.6-1.75 (m, 2H),
0.94 (t, J = 7.4Hz, 3H).
2-388 δ7.75 (d, J = 5.4Hz, 2H), 7.67 (d, J = 1.2Hz, 1H), 7.4-7.55 (m, 2H),
5.98 (bs, 1H), 4.53 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 2.20 (t, J = 7.5Hz, 2H), 1.67 (sxt, J = 7.5Hz, 2H),
0.94 (t, J = 7.5Hz, 3H).
2-389 δ7.83 (s, 2H), 7.69 (d, J = 1.5Hz, 1H), 7.45-7.55 (m, 2H),
5.91 (t, J = 6.0Hz, 1H), 4.54 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 2.20 (t, J = 7.2Hz, 2H), 1.67 (sxt, J = 7.2Hz, 2H),
0.94 (t, J = 7.2Hz, 3H).
2-390 δ7.93 (d, J = 1.8Hz, 1H), 7.83 (s, 1H), 7.68 (d, J = 1.5Hz, 1H),
7.4-7.5 (m, 2H), 5.95 (t, J = 6.0Hz, 1H), 4.53 (d, J = 6.0Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 2.20 (t, J = 7.5Hz, 2H),
1.67 (sxt, J = 7.5Hz, 2H), 0.94 (t, J = 7.5Hz, 3H).
2-391 δ7.87 (d, J = 1.8Hz, 1H), 7.86 (s, 1H), 7.80 (d, J = 7.8Hz, 1H),
7.69 (d, J = 7.8Hz, 1H), 7.59 (t, J = 7.8Hz, 1H),
7.57 (dd, J = 7.8, 1.8Hz, 1H), 7.44 (d, J = 7.8Hz, 1H),
5.98 (t, J = 6.3Hz, 1H), 4.51 (d, J = 6.3Hz, 2H), 4.10 (d, J = 17.7Hz, 1H),
3.71 (d, J = 17.7Hz, 1H), 2.20 (t, J = 7.5Hz, 2H), 1.6-1.75 (m, 2H),
0.94 (t, J = 7.5Hz, 3H).
2-392 δ7.87 (s, 1H), 7.80 (s, 1H), 7.75 (s, 1H), 7.69 (s, 1H),
7.58 (d, J = 8.1Hz, 1H), 7.47 (d, J = 8.1Hz, 1H), 5.94 (bs, 1H),
4.52 (d, J = 6.0Hz, 2H), 4.10 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H),
2.21 (t, J = 7.5Hz, 2H), 1.68 (sxt, J = 7.5Hz, 2H), 0.94 (t, J = 7.5Hz, 3H).
2-393 δ7.75 (d, J = 5.4Hz, 2H), 7.67 (d, J = 1.5Hz, 1H), 7.4-7.55 (m, 2H),
5.98 (bs, 1H), 4.53 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 2.20 (t, J = 7.5Hz, 2H), 1.67 (sxt, J = 7.5Hz, 2H),
0.93 (t, J = 7.5Hz, 3H).
2-395 δ8.10 (d, J = 1.8Hz, 1H), 7.75 (d, J = 5.7Hz, 2H),
7.60 (dd, J = 7.8, 1.8Hz, 1H), 7.42 (d, J = 7.8Hz, 1H),
5.93 (t, J = 6.0Hz, 1H), 4.47 (d, J = 6.0Hz, 2H), 4.03 (d, J = 17.4Hz, 1H),
3.64 (d, J = 17.4Hz, 1H), 2.21 (t, J = 7.5Hz, 2H), 1.68 (sxt, J = 7.5Hz, 2H),
0.95 (t, J = 7.5Hz, 3H).
2-396 δ8.30 (bs, 1H), 8.08 (s, 2H), 7.9-8.0 (m, 2H), 7.78 (d, J = 8.1Hz, 1H),
6.25 (t, J = 6.6Hz, 1H), 4.69 (d, J = 6.6Hz, 2H), 4.21 (d, J = 17.4Hz, 1H),
3.76 (d, J = 17.4Hz, 1H), 2.16 (t, J = 7.8Hz, 2H), 1.5-1.75 (m, 2H),
0.90 (t, J = 7.5Hz, 3H).
2-401 δ8.07 (s, 2H), 7.96 (s, 1H), 7.3-7.45 (m, 3H), 6.10 (t, J = 6.0Hz, 1H),
4.48 (d, J = 6.0Hz, 2H), 4.17 (d, J = 17.4Hz, 1H), 3.74 (d, J = 17.4Hz, 1H),
2.40 (sep, J = 6.9Hz, 1H), 1.16 (d, J = 6.9Hz, 6H).
2-402 δ7.95 (s, 1H), 7.84 (s, 1H), 7.79 (s, 1H), 7.69 (d, J = 1.8Hz, 1H),
7.51 (dd, J = 8.4, 1.8Hz, 1H), 7.44 (d, J = 8.4Hz, 1H),
5.95 (t, J = 6.0Hz, 1H), 4.52 (d, J = 6.0Hz, 2H), 4.10 (d, J = 17.1Hz, 1H),
3.69 (d, J = 17.1Hz, 1H), 2.3-2.5 (m, 1H), 1.17 (d, J = 6.9Hz, 6H).
2-404 δ7.75 (d, J = 5.4Hz, 2H), 7.67 (d, J = 1.2Hz, 1H), 7.35-7.5 (m, 2H),
6.03 (bs, 1H), 4.52 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 2.41 (sep, J = 6.9Hz, 1H), 1.17 (d, J = 6.9Hz, 6H).
2-405 δ7.83 (s, 2H), 7.69 (d, J = 1.5Hz, 1H), 7.4-7.55 (m, 2H),
5.93 (t, J = 6.0Hz, 1H), 4.53 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 2.40 (sep, J = 6.9Hz, 1H), 1.17 (t, J = 6.9Hz, 6H).
2-406 δ7.93 (d, J = 1.8Hz, 1H), 7.82 (s, 1H), 7.69 (d, J = 1.5Hz, 1H),
7.4-7.5 (m, 2H), 5.96 (t, J = 6.3Hz, 1H), 4.53 (d, J = 6.3Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
2.40 (sep, J = 6.9Hz, 1H), 1.17 (d, J = 6.9Hz, 6H).
2-407 δ7.88 (s, 1H), 7.82 (s, 1H), 7.75 (s, 1H), 7.69 (s, 1H),
7.58 (d, J = 8.1Hz, 1H), 7.46 (d, J = 8.1Hz, 1H), 5.96 (bs, 1H),
4.51 (d, J = 6.0Hz, 2H), 4.10 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H),
2.40 (sep, J = 6.9Hz, 1H), 1.17 (d, J = 6.9Hz, 6H).
2-408 δ7.96 (s, 1H), 7.88 (s, 1H), 7.84 (s, 1H), 7.80 (s, 1H),
7.58 (d, J = 8.1Hz, 1H), 7.45 (d, J = 8.1Hz, 1H), 5.69 (bs, 1H),
4.51 (d, J = 6.3Hz, 2H), 4.10 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H),
2.40 (qui, J = 6.9Hz, 1H), 1.17 (d, J = 6.9Hz, 6H).
2-409 δ7.75 (d, J = 5.4Hz, 2H), 7.68 (d, J = 1.5Hz, 1H),
7.49 (dd, J = 7.8, 1.2Hz, 1H), 7.44 (d, J = 7.8Hz, 1H), 6.02 (bs, 1H),
4.52 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H),
2.41 (sep, J = 6.9Hz, 1H), 1.17 (d, J = 6.9Hz, 6H).
2-410 δ7.94 (s, 1H), 7.87 (s, 1H), 7.83 (s, 1H), 7.58 (d, J = 8.1Hz, 1H),
7.45 (d, J = 8.1Hz, 1H), 5.98 (bs, 1H), 4.51 (d, J = 6.0Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
2.41 (sep, J = 7.2Hz, 1H), 1.17 (d, J = 7.2Hz, 6H).
2-412 δ8.10 (d, J = 1.8Hz, 1H), 7.75 (d, J = 5.7Hz, 2H),
7.60 (dd, J = 7.8, 1.8Hz, 1H), 7.42 (d, J = 7.8Hz, 1H),
5.95 (t, J = 6.0Hz, 1H), 4.46 (d, J = 6.0Hz, 2H), 4.03 (d, J = 17.4Hz, 1H),
3.64 (d, J = 17.4Hz, 1H), 2.41 (sep, J = 6.9Hz, 1H), 1.18 (d, J = 6.9Hz, 6H).
2-413 δ8.30 (bs, 1H), 7.9-8.15 (m, 4H), 7.78 (d, J = 8.1Hz, 1H),
6.25 (t, J = 6.6Hz, 1H), 4.68 (d, J = 6.6Hz, 2H), 4.21 (d, J = 17.4Hz, 1H),
3.76 (d, J = 17.4Hz, 1H), 2.3-2.45 (m, 1H), 1.13 (d, J = 6.9Hz, 6H).
2-418 δ8.08 (s, 2H), 7.98 (s, 1H), 7.76 (d, J = 8.4Hz, 2H),
7.56 (d, J = 8.4Hz, 2H), 6.26 (d, J = 8.4Hz, 1H), 6.01 (d, J = 8.4Hz, 1H),
4.20 (d, J = 17.4Hz, 1H), 3.76 (d, J = 17.4Hz, 1H),
2.44 (sep, J = 6.9Hz, 1H), 1.22 (d, J = 6.9Hz, 3H), 1.19 (d, J = 6.9Hz, 3H).
2-419 δ8.07 (s, 2H), 7.97 (s, 1H), 7.3-7.5 (m, 3H), 6.03 (t, J = 6.0Hz, 1H),
4.52 (d, J = 6.0Hz, 2H), 4.16 (d, J = 17.4Hz, 1H), 3.71 (d, J = 17.4Hz, 1H),
1.4-1.55 (m, 1H), 0.95-1.1 (m, 2H), 0.7-0.85 (m, 2H).
2-420 δ7.81 (d, J = 6.3Hz, 1H), 7.66 (d, J = 1.2Hz, 1H), 7.4-7.6 (m, 3H),
7.1-7.2 (m, 1H), 6.28 (t, J = 6.0Hz, 1H), 4.53 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 1.35-1.45 (m, 1H),
0.9-1.05 (m, 2H), 0.7-0.85 (m, 2H).
2-421 δ7.95 (s, 1H), 7.83 (s, 1H), 7.79 (s, 1H), 7.69 (d, J = 1.5Hz, 1H),
7.51 (dd, J = 8.4, 1.5Hz, 1H), 7.46 (d, J = 8.4Hz, 1H),
6.10 (t, J = 6.0Hz, 1H), 4.55 (d, J = 6.0Hz, 2H), 4.10 (d, J = 17.1Hz, 1H),
3.69 (d, J = 17.1Hz, 1H), 1.35-1.45 (m, 1H), 0.95-1.05 (m, 2H),
0.7-0.8 (m, 2H).
2-423 δ7.75 (d, J = 5.7Hz, 2H), 7.66 (d, J = 1.2Hz, 1H), 7.35-7.5 (m, 2H),
6.15-6.35 (m, 1H), 4.56 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 1.35-1.45 (m, 1H), 0.9-1.05 (m, 2H),
0.7-0.9 (m, 2H).
2-424 δ7.82 (s, 2H), 7.67 (d, J = 1.2Hz, 1H), 7.4-7.55 (m, 2H),
6.13 (t, J = 6.0Hz, 1H), 4.55 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.4Hz, 1H),
3.62 (d, J = 17.4Hz, 1H), 1.35-1.45 (m, 1H), 0.95-1.05 (m, 2H),
0.7-0.85 (m, 2H).
2-425 δ7.93 (s, 1H), 7.83 (s, 1H), 7.68 (s, 1H), 7.4-7.55 (m, 2H),
6.22 (bs, 1H), 4.54 (d, J = 6.0Hz, 2H), 4.10 (d, J = 17.4Hz, 1H),
3.68 (d, J = 17.4Hz, 1H), 1.35-1.45 (m, 1H), 0.9-1.05 (m, 2H),
0.7-0.85 (m, 2H).
2-426 δ7.87 (d, J = 1.7Hz, 1H), 7.86 (s, 1H), 7.80 (d, J = 7.8Hz, 1H),
7.69 (d, J = 7.8Hz, 1H), 7.59 (t, J = 7.8Hz, 1H),
7.57 (dd, J = 8.1, 1.7Hz, 1H), 7.45 (d, J = 8.1Hz, 1H),
6.14 (t, J = 6.2Hz, 1H), 4.53 (d, J = 6.2Hz, 2H), 4.10 (d, J = 17.4Hz, 1H),
3.71 (d, J = 17.4Hz, 1H), 1.3-1.45 (m, 1H), 0.95-1.1 (m, 2H),
0.7-0.85 (m, 2H).
2-427 δ7.88 (s, 1H), 7.82 (s, 1H), 7.75 (s, 1H), 7.69 (s, 1H),
7.58 (d, J = 8.1Hz, 1H), 7.47 (d, J = 8.1Hz, 1H), 6.12 (bs, 1H),
4.54 (d, J = 6.0Hz, 2H), 4.10 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H),
1.3-1.45 (m, 1H), 0.95-1.05 (m, 2H), 0.7-0.85 (m, 2H).
2-429 δ7.75 (d, J = 5.4Hz, 2H), 7.66 (d, J = 1.5Hz, 1H),
7.49 (dd, J = 7.8, 1.2Hz, 1H), 7.44 (d, J = 7.8Hz, 1H), 6.23 (bs, 1H),
4.54 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H),
1.40 (qui, J = 7.5Hz, 1H), 0.95-1.1 (m, 2H), 0.7-0.9 (m, 2H).
2-430 δ7.93 (s, 1H), 7.87 (s, 1H), 7.83 (s, 1H), 7.58 (d, J = 8.1Hz, 1H),
7.47 (d, J = 8.1Hz, 1H), 6.12 (bs, 1H), 4.54 (d, J = 6.0Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 1.3-1.45 (m, 1H),
0.95-1.05 (m, 2H), 0.7-0.85 (m, 2H).
2-432 δ8.10 (d, J = 1.8Hz, 1H), 7.76 (d, J = 5.7Hz, 2H),
7.61 (dd, J = 7.8, 1.8Hz, 1H), 7.43 (d, J = 7.8Hz, 1H),
6.11 (t, J = 6.0Hz, 1H), 4.49 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.4Hz, 1H),
3.64 (d, J = 17.4Hz, 1H), 1.35-1.45 (m, 1H), 0.95-1.05 (m, 2H),
0.75-0.85 (m, 2H).
2-433 δ8.07 (s, 2H), 7.96 (s, 1H), 7.76 (d, J = 1.8Hz, 1H),
7.65 (dd, J = 8.1, 1.8Hz, 1H), 7.45 (d, J = 8.1Hz, 1H), 6.14 (bs, 1H),
4.62 (d, J = 6.0Hz, 2H), 4.18 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H),
3.41 (s, 1H), 1.3-1.4 (m, 1H), 0.95-1.05 (m, 2H), 0.7-0.85 (m, 2H).
2-435 δ8.31 (bs, 1H), 8.08 (s, 2H), 7.9-8.0 (m, 2H), 7.77 (d, J = 8.1Hz, 1H),
6.45 (t, J = 6.6Hz, 1H), 4.72 (d, J = 6.6Hz, 2H), 4.21 (d, J = 17.4Hz, 1H),
3.77 (d, J = 17.4Hz, 1H), 1.3-1.45 (m, 1H), 0.9-1.0 (m, 2H),
0.7-0.85 (m, 2H).
2-437 δ7.97 (s, 1H), 7.84 (s, 1H), 7.80 (s, 1H), 7.64 (d, J = 8.1Hz, 2H),
7.39 (d, J = 8.1Hz, 2H), 5.63 (d, J = 7.2Hz, 1H), 5.14 (qui, J = 7.2Hz, 1H),
4.12 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H), 1.50 (d, J = 7.2Hz, 3H),
1.3-1.4 (m, 1H), 0.9-1.05 (m, 2H), 0.7-0.8 (m, 2H).
2-439 δ8.08 (s, 2H), 7.96 (s, 1H), 7.63 (d, J = 8.1Hz, 2H),
7.38 (d, J = 8.1Hz, 2H), 5.94 (t, J = 7.5Hz, 1H), 5.05-5.2 (m, 1H),
4.18 (d, J = 17.4Hz, 1H), 3.73 (d, J = 17.4Hz, 1H), 1.49 (d, J = 7.2Hz, 3H),
1.3-1.4 (m, 1H), 0.9-1.0 (m, 2H), 0.7-0.8 (m, 2H).
2-441 δ7.94 (s, 1H), 7.84 (s, 1H), 7.63 (d, J = 8.1Hz, 2H),
7.39 (d, J = 8.1Hz, 2H), 5.83 (d, J = 7.2Hz, 1H), 5.1-5.2 (m, 1H),
4.17 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H), 1.50 (d, J = 6.9Hz, 3H),
1.25-1.4 (m, 1H), 0.9-1.05 (m, 2H), 0.65-0.85 (m, 2H).
2-445 δ7.58 (d, J = 8.4Hz, 2H), 7.47 (s, 2H), 7.25-7.4 (m, 3H),
6.58 (d, J = 7.2Hz, 1H), 5.14 (q, J = 6.9Hz, 1H), 4.03 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 2.86 (d, J = 6.9Hz, 2H), 1.98 (s, 3H),
1.35-1.5 (m, 1H), 0.85-1.0 (m, 2H), 0.6-0.8 (m, 2H).
2-446 δ8.08 (s, 2H), 7.97 (s, 1H), 7.68 (d, J = 8.4Hz, 2H),
7.59 (d, J = 8.4Hz, 2H), 6.05-6.15 (m, 1H), 6.10 (bs, 1H),
4.18 (d, J = 17.1Hz, 1H), 3.74 (d, J = 17.1Hz, 1H), 2.54 (d, J = 2.1Hz, 1H),
1.3-1.4 (m, 1H), 0.95-1.1 (m, 2H), 0.75-0.85 (m, 2H).
2-448 δ8.07 (s, 2H), 7.98 (s, 1H), 7.6-7.85 (m, 3H), 6.45 (d, J = 8.1Hz, 1H),
6.30 (d, J = 8.1Hz, 1H), 4.18 (d, J = 17.4Hz, 1H), 3.74 (d, J = 17.4Hz, 1H),
1.35-1.45 (m, 1H), 0.8-1.15 (m, 4H).
2-449 δ8.07 (s, 2H), 7.9-8.1 (m, 2H), 7.65-7.8 (m, 2H), 6.40 (d, J = 6.9Hz, 1H),
6.26 (d, J = 6.9Hz, 1H), 4.18 (d, J = 17.4Hz, 1H), 3.74 (d, J = 17.4Hz, 1H),
1.35-1.5 (m, 1H), 0.95-1.1 (m, 2H), 0.75-0.95 (m, 2H).
2-450 δ8.19 (d, J = 9.0Hz, 1H), 7.73 (d, J = 3.3Hz, 2H), 7.49 (d, J = 1.8Hz, 2H),
7.44 (t, J = 1.8Hz, 1H), 6.53 (d, J = 7.8Hz, 1H), 6.11 (d, J = 7.8Hz, 1H),
4.06 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H), 1.35-1.45 (m, 1H),
1.0-1.1 (m, 2H), 0.75-0.95 (m, 2H).
2-451 δ8.24 and 8.21 (s, 1H), 8.07 (s, 2H), 7.99 (s, 1H), 7.76 (s, 2H),
6.24 (d, J = 7.8Hz, 1H), 6.13 (d, J = 7.8Hz, 1H), 4.15 (d, J = 17.4Hz, 1H),
3.73 (d, J = 17.4Hz, 1H), 1.35-1.45 (m, 1H), 1.0-1.1 (m, 2H),
0.8-0.9 (m, 2H).
2-452 δ7.64 (d, J = 8.4Hz, 1H), 7.45-7.6 (m, 4H), 7.4-7.45 (m, 1H),
6.62 (d, J = 8.4Hz, 1H), 6.18 (d, J = 8.4Hz, 1H), 4.08 (d, J = 17.4Hz, 1H),
3.71 (d, J = 17.4Hz, 1H), 2.36 (s, 3H), 1.35-1.5 (m, 1H),
0.95-1.1 (m, 2H), 0.75-0.95 (m, 2H).
2-453 δ7.78 (d, J = 7.5Hz, 1H), 7.64 (d, J = 8.4Hz, 2H), 7.55 (d, J = 8.4Hz, 2H),
7.51 (s, 2H), 7.4-7.45 (m, 1H), 7.26 (s, 1H), 6.26 (s, 1H),
5.62 (d, J = 7.5Hz, 1H), 4.10 (d, J = 17.4Hz, 1H), 3.75 (d, J = 17.4Hz, 1H),
1.55-1.7 (m, 1H), 0.8-1.0 (m, 2H), 0.65-0.8 (m, 2H).
2-454 δ8.07 (s, 2H), 7.96 (s, 1H), 7.3-7.45 (m, 3H), 6.07 (bs, 1H),
4.49 (d, J = 6.0Hz, 2H), 4.17 (d, J = 17.4Hz, 1H), 3.74 (d, J = 17.4Hz, 1H),
2.0-2.2 (m, 3H), 0.93 (d, J = 6.6Hz, 6H).
2-455 δ7.95 (s, 1H), 7.84 (s, 1H), 7.79 (s, 1H), 7.69 (d, J = 1.8Hz, 1H),
7.51 (dd, J = 8.4, 1.8Hz, 1H), 7.44 (d, J = 8.4Hz, 1H),
5.93 (t, J = 6.2Hz, 1H), 4.54 (d, J = 6.2Hz, 2H), 4.10 (d, J = 17.2Hz, 1H),
3.69 (d, J = 17.2Hz, 1H), 2.0-2.2 (m, 3H), 0.93 (d, J = 6.5Hz, 6H).
2-457 δ7.75 (d, J = 6.0Hz, 2H), 7.65 (d, J = 1.5Hz, 1H), 7.35-7.5 (m, 2H),
6.14 (bs, 1H), 4.51 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.68 (d, J = 17.4Hz, 1H), 2.0-2.2 (m, 3H), 0.93 (d, J = 6.3Hz, 6H).
2-458 δ7.83 (s, 2H), 7.69 (d, J = 1.5Hz, 1H), 7.4-7.55 (m, 2H),
5.89 (t, J = 6.0Hz, 1H), 4.54 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 2.0-2.2 (m, 3H), 0.94 (d, J = 6.3Hz, 6H).
2-459 δ7.93 (d, J = 1.8Hz, 1H), 7.82 (s, 1H), 7.68 (d, J = 1.5Hz, 1H),
7.4-7.5 (m, 2H), 5.97 (t, J = 6.0Hz, 1H), 4.53 (d, J = 6.0Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H), 2.0-2.2 (m, 3H),
0.93 (d, J = 6.6Hz, 6H).
2-461 δ7.96 (s, 1H), 7.88 (s, 1H), 7.84 (s, 1H), 7.81 (s, 1H),
7.58 (d, J = 8.1Hz, 1H), 7.47 (d, J = 8.1Hz, 1H), 5.92 (bs, 1H),
4.52 (d, J = 6.0Hz, 2H), 4.10 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H),
2.05-2.2 (m, 3H), 0.94 (d, J = 6.6Hz, 6H).
2-462 δ7.75 (d, J = 5.4Hz, 2H), 7.68 (d, J = 1.5Hz, 1H),
7.49 (dd, J = 7.8, 1.2Hz, 1H), 7.44 (d, J = 7.8Hz, 1H), 6.03 (bs, 1H),
4.52 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H),
2.05-2.2 (m, 3H), 0.93 (d, J = 6.6Hz, 6H).
2-463 δ7.93 (s, 1H), 7.87 (s, 1H), 7.83 (s, 1H), 7.58 (d, J = 8.1Hz, 1H),
7.45 (d, J = 8.1Hz, 1H), 5.98 (bs, 1H), 4.51 (d, J = 6.0Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 2.05-2.2 (m, 3H),
0.93 (d, J = 6.6Hz, 6H).
2-464 δ8.10 (d, J = 1.8Hz, 1H), 7.75 (d, J = 5.7Hz, 2H),
7.61 (dd, J = 7.8, 1.8Hz, 1H), 7.44 (d, J = 7.8Hz, 1H),
5.91 (t, J = 6.0Hz, 1H), 4.48 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.4Hz, 1H),
3.64 (d, J = 17.4Hz, 1H), 2.05-2.2 (m, 3H), 0.95 (d, J = 6.6Hz, 6H).
2-465 δ8.29 (bs, 1H), 7.9-8.2 (m, 4H), 7.79 (d, J = 8.1Hz, 1H),
6.22 (t, J = 6.6Hz, 1H), 4.69 (d, J = 6.6Hz, 2H), 4.21 (d, J = 17.4Hz, 1H),
3.76 (d, J = 17.4Hz, 1H), 2.0-2.15 (m, 2H), 0.85-1.2 (m, 7H).
2-470 δ7.86 (s, 1H), 7.82 (d, J = 7.8Hz, 1H), 7.65-7.75 (m, 2H),
7.59 (t, J = 7.8Hz, 1H), 7.45-7.55 (m, 2H), 6.47 (t, J = 6.2Hz, 1H),
4.56 (d, J = 6.2Hz, 2H), 4.11 (d, J = 17.5Hz, 1H), 3.72 (d, J = 17.5Hz, 1H),
2.19 (d, J = 7.2Hz, 2H), 0.9-1.1 (m, 1H), 0.55-0.7 (m, 2H),
0.15-0.3 (m, 2H).
2-473 δ7.75 (d, J = 5.7Hz, 2H), 7.68 (s, 1H), 7.4-7.5 (m, 2H), 6.52 (bs, 1H),
4.56 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
2.20 (d, J = 7.2Hz, 2H), 0.9-1.05 (m, 1H), 0.55-0.7 (m, 2H),
0.2-0.35 (m, 2H).
2-474 δ7.83 (s, 2H), 7.69 (d, J = 1.5Hz, 1H), 7.4-7.55 (m, 2H),
6.50 (t, J = 6.0Hz, 1H), 4.54 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 2.18 (d, J = 7.2Hz, 2H), 0.9-1.05 (m, 1H),
0.45-0.7 (m, 2H), 0.15-0.3 (m, 2H).
2-475 δ7.88 (d, J = 1.8Hz, 1H), 7.86 (s, 1H), 7.80 (d, J = 7.8Hz, 1H),
7.69 (d, J = 7.8Hz, 1H), 7.55-7.65 (m, 2H), 7.45 (d, J = 7.8Hz, 1H),
6.49 (t, J = 6.0Hz, 1H), 4.54 (d, J = 6.0Hz, 2H), 4.10 (d, J = 17.7Hz, 1H),
3.71 (d, J = 17.7Hz, 1H), 2.19 (d, J = 7.2Hz, 2H), 0.9-1.1 (m, 1H),
0.55-0.7 (m, 2H), 0.15-0.3 (m, 2H).
2-476 δ7.89 (s, 1H), 7.82 (s, 1H), 7.75 (s, 1H), 7.69 (s, 1H),
7.58 (d, J = 8.1Hz, 1H), 7.45 (d, J = 8.1Hz, 1H), 6.49 (t, J = 6.0Hz, 1H),
4.54 (d, J = 6.0Hz, 2H), 4.10 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H),
2.20 (d, J = 7.2Hz, 2H), 0.85-1.05 (m, 1H), 0.6-0.65 (m, 2H),
0.2-0.3 (m, 2H).
2-479 δ7.81 (s, 1H), 7.76 (s, 1H), 7.68 (s, 1H), 7.65 (d, J = 8.4Hz, 2H),
7.38 (d, J = 8.4Hz, 2H), 6.08 (d, J = 7.5Hz, 1H), 5.17 (qui, J = 7.5Hz, 1H),
4.12 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H), 2.17 (d, J = 7.5Hz, 2H),
1.50 (d, J = 6.9Hz, 3H), 0.9-1.0 (m, 1H), 0.55-0.65 (m, 2H),
0.2-0.25 (m, 2H).
2-480 δ8.15 (s, 1H), 8.02 (s, 1H), 7.83 (s, 1H), 7.64 (d, J = 8.4Hz, 2H),
7.39 (d, J = 8.4Hz, 2H), 6.09 (d, J = 7.5Hz, 1H), 5.17 (qui, J = 7.5Hz, 1H),
4.11 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H), 2.17 (d, J = 7.5Hz, 2H),
1.50 (d, J = 7.5Hz, 3H), 0.9-1.0 (m, 1H), 0.55-0.65 (m, 2H),
0.2-0.25 (m, 2H).
2-483 δ7.6-7.8 (m, 3H), 7.49 (s, 2H), 7.4-7.45 (m, 1H), 6.77 (d, J = 7.2Hz, 1H),
6.28 (d, J = 7.2Hz, 1H), 4.06 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H),
2.22 (d, J = 7.2Hz, 2H), 0.85-1.05 (m, 1H), 0.6-0.7 (m, 2H),
0.2-0.3 (m, 2H).
2-484 δ7.66 (d, J = 8.4Hz, 1H), 7.45-7.6 (m, 4H), 7.4-7.45 (m, 1H),
6.40 (d, J = 8.4Hz, 1H), 6.22 (d, J = 8.4Hz, 1H), 4.08 (d, J = 17.4Hz, 1H),
3.70 (d, J = 17.4Hz, 1H), 2.38 (s, 3H), 2.22 (d, J = 7.2Hz, 2H),
0.85-1.05 (m, 1H), 0.55-0.65 (m, 2H), 0.15-0.25 (m, 2H).
2-491 δ8.07 (s, 2H), 7.97 (s, 1H), 7.72 (d, J = 1.5Hz, 1H), 7.5-7.6 (m, 1H),
7.4-7.5 (m, 1H), 7.34 (t, J = 6.0Hz, 1H), 4.56 (d, J = 6.0Hz, 2H),
4.17 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H),
1.34 (dd, J = 6.0, 5.1Hz, 2H), 1.70 (dd, J = 6.0, 5.1Hz, 2H).
2-492 δ8.08 (s, 2H), 7.97 (s, 1H), 7.55 (s, 1H), 7.5-7.6 (m, 1H),
7.4-7.5 (m, 1H), 7.20 (t, J = 6.0Hz, 1H), 4.55 (d, J = 6.0Hz, 2H),
4.35-4.45 (m, 1H), 4.18 (d, J = 17.4Hz, 1H), 3.85-4.05 (m, 2H),
3.75 (d, J = 17.4Hz, 1H), 2.2-2.4 (m, 1H), 1.8-2.15 (m, 3H).
2-498 δ8.11 (s, 1H), 8.07 (s, 2H), 7.96 (s, 1H), 7.62 (d, J = 8.4Hz, 1H),
7.39 (d, J = 8.4Hz, 1H), 6.30 (bs, 1H), 4.45 (d, J = 6.0Hz, 2H),
4.16 (d, J = 17.4Hz, 1H), 3.75-4.0 (m, 4H), 3.72 (d, J = 17.4Hz, 1H),
2.9-3.0 (m, 1H), 2.15-2.2 (m, 2H).
2-499 δ8.29 (bs, 1H), 8.08 (s, 2H), 7.9-8.0 (m, 2H), 7.75 (d, J = 8.1Hz, 1H),
6.50 (t, J = 6.6Hz, 1H), 4.69 (d, J = 6.6Hz, 2H), 4.21 (d, J = 17.4Hz, 1H),
3.7-4.0 (m, 5H), 2.85-3.0 (m, 1H), 2.0-2.2 (m, 2H).
2-500 δ7.81 (s, 1H), 7.76 (s, 1H), 7.68 (s, 1H), 7.64 (d, J = 8.4Hz, 2H),
7.3-7.4 (m, 2H), 5.93 (d, J = 7.5Hz, 1H), 5.11 (qui, J = 7.5Hz, 1H),
4.12 (d, J = 17.4Hz, 1H), 3.75-4.0 (m, 4H), 3.70 (d, J = 17.4Hz, 1H),
2.90 (qui, J = 5.7Hz, 1H), 2.05-2.2 (m, 2H),
1.49 and 1.48 (d, J = 6.9Hz, 3H).
2-501 δ8.08 (s, 2H), 7.98 (s, 1H), 7.75 (d, J = 8.4Hz, 2H),
7.56 (d, J = 8.4Hz, 2H), 6.38 (d, J = 6.9Hz, 1H), 6.21 (d, J = 8.4Hz, 1H),
3.7-4.25 (m, 6H), 2.95-3.05 (m, 1H), 2.1-2.3 (m, 2H).
2-502 δ7.69 (d, J = 8.7Hz, 1H), 7.55-7.65 (m, 2H), 7.4-7.55 (m, 3H),
7.30 (d, J = 8.7Hz, 1H), 6.18 (d, J = 8.7Hz, 1H), 4.08 (d, J = 17.4Hz, 1H),
3.70 (d, J = 17.4Hz, 1H), 3.34 (d, J = 17.8Hz, 1H), 3.27 (d, J = 17.8Hz, 1H),
2.54 (q, J = 7.5Hz, 2H), 2.40 (s, 3H), 1.25 (t, J = 7.5Hz, 3H).
2-503 δ7.95-8.1 (m, 1H), 7.4-7.7 (m, 6H), 6.14 (t, J = 7.5Hz, 1H),
4.07 (d, J = 17.4Hz, 1H), 3.65-3.8 (m, 2H), 3.25-3.4 (m, 1H),
2.4-3.0 (m, 2H), 2.47 and 2.41 (s, 3H), 1.26 (t, J = 7.2Hz, 3H).
2-504 δ7.45-7.7 (m, 6H), 7.42 (s, 1H), 6.07 (d, J = 7.2Hz, 1H),
4.08 (d, J = 17.4Hz, 1H), 3.93 (s, 2H), 3.70 (d, J = 17.4Hz, 1H),
3.16 (q, J = 7.5Hz, 2H), 2.38 (s, 3H), 1.37 (t, J = 7.5Hz, 3H).
2-505 δ8.62 and 8.56 (d, J = 7.8Hz, 1H), 7.66 (d, J = 7.5Hz, 1H),
7.45-7.6 (m, 4H), 7.4-7.45 (m, 1H), 6.09 (d, J = 7.5Hz, 1H),
3.85-4.1 (m, 3H), 3.71 (d, J = 17.4Hz, 1H), 3.05-3.25 (m, 3H),
2.40 and 2.39 (s, 3H), 1.37 and 1.35 (t, J = 7.5Hz, 3H).
2-506 δ8.07 (s, 2H), 7.96 (s, 1H), 7.70 (s, 1H), 7.45-7.55 (m, 2H),
6.48 (td, J = 3.3, 0.9Hz, 1H), 6.30 (t, J = 6.0Hz, 1H),
4.60 (d, J = 6.0Hz, 2H), 4.16 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H),
3.40 (t, J = 8.7Hz, 2H), 2.91 (td, J = 8.7, 3.3Hz, 2H).
2-507 δ8.07 (s, 2H), 7.97 (s, 1H), 7.66 (s, 1H), 7.4-7.55 (m, 2H),
7.38 (t, J = 6.0Hz, 1H), 4.45-4.6 (m, 2H),
4.17 and 4.16 (d, J = 17.4Hz, 1H), 3.63 (d, J = 17.4Hz, 1H),
2.9-3.1 (m, 2H), 2.6-2.75 (m, 1H), 2.4-2.55 (m, 1H),
3.4-3.3 and 2.4-2.55 (m, 1H), 1.35-2.25 (m, 6H).
2-508 δ8.07 (s, 2H), 7.96 (s, 1H), 7.66 (s, 1H), 7.5-7.65 (m, 1H),
7.3-7.4 (m, 1H), 6.47 (t, J = 6.0Hz, 1H), 4.45-4.6 (m, 2H),
4.17 (d, J = 17.4Hz, 1H), 3.74 (d, J = 17.4Hz, 1H), 3.1-3.25 (m, 1H),
2.65-2.85 (m, 2H), 2.3-2.45 (m, 2H), 1.75-2.05 (m, 3H),
1.35-1.65 (m, 3H).
2-509 δ8.07 (s, 2H), 7.97 (s, 1H), 7.65 (d, J = 1.8Hz, 1H), 7.4-7.55 (m, 2H),
6.92 (t, J = 6.0Hz, 1H), 4.4-4.6 (m, 2H), 4.20 (d, J = 17.4Hz, 1H),
3.75 (d, J = 17.4Hz, 1H), 3.4-3.55 (m, 1H), 2.9-3.15 (m, 3H),
2.36 (dd, J = 8.4, 7.2Hz, 1H), 1.95-2.2 (m, 3H), 1.7-1.9 (m, 2H),
1.4-1.65 (m, 1H).
2-510 δ7.6-7.7 (m, 3H), 7.45-7.55 (m, 1H), 7.35-7.45 (m, 1H),
7.16 (t, J = 6.0Hz, 1H), 4.55 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
4.02 (s, 2H), 3.68 (d, J = 17.4Hz, 1H), 3.11 (s, 3H), 2.12 (s, 3H).
2-511 δ8.07 (s, 2H), 7.97 (s, 1H), 7.67 (d, J = 1.8Hz, 1H), 7.4-7.6 (m, 2H),
7.00 (t, J = 6.3Hz, 1H), 4.56 and 4.50 (d, J = 6.3Hz, 2H),
4.20 and 4.14 (s, 2H), 4.08 and 4.04 (s, 2H), 4.04 (d, J = 17.4Hz, 1H),
3.74 (d, J = 17.4Hz, 1H), 3.42 (s, 3H), 3.09 and 2.96 (s, 3H).
2-512 δ8.09 (s, 2H), 7.97 (s, 1H), 7.65-7.8 (m, 1H), 7.4-7.5 (m, 1H),
7.2-7.4 (m, 1H), 4.55-4.65 (m, 2H), 4.18 (d, J = 17.4Hz, 1H),
3.92 (s, 2H), 3.72 (d, J = 17.4Hz, 1H), 3.76 and 3.71 (s, 3H),
2.97 and 2.92 (s, 3H).
2-513 δ7.67 (d, J = 1.5Hz, 1H), 7.64 (s, 2H), 7.45-7.55 (m, 1H),
7.35-7.45 (m, 1H), 6.59 (bs, 1H), 4.52 (d, J = 6.0Hz, 2H),
4.06 (d, J = 17.4Hz, 1H), 3.94 (s, 2H), 3.74 (s, 3H),
3.67 (d, J = 17.4Hz, 1H), 2.72 (sep, J = 3.6Hz, 1H), 0.7-0.8 (m, 2H),
0.6-0.7 (m, 2H).
2-514 δ7.66 (d, J = 1.2Hz, 1H), 7.63 (s, 2H), 7.45-7.55 (m, 1H),
7.35-7.45 (m, 1H), 6.77 and 6.49 (bs, 1H), 4.91 (sep, J = 6.3Hz, 1H),
4.54 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.93 (s, 2H),
3.66 (d, J = 17.4Hz, 1H), 2.97 (s, 3H), 1.24 (d, J = 6.3Hz, 6H).
2-515 δ7.66 (s, 1H), 7.64 (s, 2H), 7.45-7.55 (m, 1H), 7.35-7.45 (m, 1H),
6.65 (bs, 1H), 4.53 (d, J = 6.0Hz, 2H), 4.07 (d, J = 17.4Hz, 1H),
4.07 (s, 2H), 3.67 (d, J = 17.4Hz, 1H), 3.08 (s, 3H), 2.35 (s, 3H).
2-516 δ7.66 (d, J = 1.8Hz, 1H), 7.64 (s, 2H), 7.5-7.55 (m, 1H),
7.35-7.45 (m, 1H), 7.02 (t, J = 6.3Hz, 1H), 4.55 (d, J = 6.3Hz, 2H),
4.07 (d, J = 17.4Hz, 1H), 3.84 (s, 2H), 3.69 (d, J = 17.4Hz, 1H),
2.94 (s, 3H), 2.91 (s, 3H).
2-518 δ7.77 (t, J = 6.3Hz, 1H), 7.67 (t, J = 1.8Hz, 1H), 7.63 (s, 2H),
7.52 and 7.49 (d, J = 1.8Hz, 1H), 7.42 and 7.40 (s, 1H),
4.54 (d, J = 6.3Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H),
3.10 (q, J = 7.2Hz, 1H), 2.38 (s, 3H), 1.41 (bs, 1H),
1.31 (d, J = 7.2Hz, 3H).
2-519 δ7.67 (t, J = 1.8Hz, 1H), 7.63 (s, 2H), 7.52 and 7.49 (d, J = 1.8Hz, 1H),
7.42 and 7.40 (s, 1H), 6.70 (bs, 1H), 4.78 (bs, 1H),
4.55 (dd, J = 15.9, 6.3Hz, 1H), 4.47 (dd, J = 15.9, 6.3Hz, 1H),
4.06 (d, J = 17.4Hz, 1H), 3.73 (s, 3H), 3.67 (d, J = 17.4Hz, 1H),
2.79 (s, 3H), 1.36 (d, J = 7.2Hz, 3H).
2-520 δ8.07 (s, 2H), 7.97 (s, 1H), 7.70 (s, 1H), 7.55 (d, J = 7.8Hz, 1H),
7.39 (d, J = 7.8Hz, 1H), 7.24 (t, J = 6.0Hz, 1H),
4.98 (dd, J = 11.1, 5.7Hz, 1H), 4.61 (dd, J = 15.3, 6.0Hz, 1H),
4.50 (dd, J = 15.3, 6.0Hz, 1H), 4.11 (d, J = 17.7Hz, 1H),
3.72 (d, J = 17.7Hz, 1H), 3.33 (dd, J = 17.7, 11.1Hz, 1H),
3.22 (dd, J = 17.7, 5.7Hz, 1H), 2.02 (s, 3H).
2-521 δ7.6-7.8 (m, 4H), 7.45-7.55 (m, 1H), 7.35-7.45 (m, 1H), 6.89 (bs, 1H),
5.78 (bs, 1H), 4.53 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 3.25 (s, 2H).
2-522 δ8.06 (s, 2H), 7.96 (s, 1H), 7.55 (d, J = 1.8Hz, 1H), 7.35-7.5 (m, 1H),
7.15-7.35 (m, 2H), 5.18 (bs, 2H), 4.40 (d, J = 6.0Hz, 2H),
4.17 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H), 3.05 (s, 3H).
2-523 δ7.64 (s, 1H), 7.63 (s, 2H), 7.35-7.5 (m, 2H), 7.17 (bs, 1H),
5.00 (s, 2H), 4.50 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.97 (q, J = 7.2Hz, 2H), 3.67 (d, J = 17.4Hz, 1H), 3.09 (s, 2H),
1.23 (t, J = 7.2Hz, 3H).
2-527 δ8.11 (d, J = 1.8Hz, 1H), 8.08 (s, 2H), 7.97 (s, 1H),
7.62 (dd, J = 8.4, 2.1Hz, 1H), 7.45 (d, J = 8.4Hz, 1H),
6.27 (t, J = 5.7Hz, 1H), 4.48 (d, J = 6.3Hz, 2H), 4.16 (d, J = 17.1Hz, 1H),
3.72 (d, J = 17.1Hz, 1H), 2.45-2.6 (m, 4H), 2.01 (d, J = 2.4Hz, 1H).
2-528 δ8.08 (s, 2H), 7.98 (s, 1H), 7.75 (d, J = 8.4Hz, 2H),
7.58 (d, J = 8.4Hz, 2H), 6.2-6.35 (m, 2H), 4.21 (d, J = 17.4Hz, 1H),
3.76 (d, J = 17.4Hz, 1H), 2.4-2.65 (m, 4H), 2.02 (t, J = 2.4Hz, 1H).
2-533 δ8.10 (d, J = 1.2Hz, 1H), 8.06 (s, 2H), 7.97 (s, 1H), 7.76 (s, 1H),
7.5-7.6 (m, 2H), 7.32 (d, J = 1.2Hz, 1H), 7.05-7.1 (m, 1H),
6.36 (t, J = 6.0Hz, 1H), 4.70 (d, J = 6.0Hz, 2H), 4.17 (d, J = 17.4Hz, 1H),
3.72 (d, J = 17.4Hz, 1H).
2-534 δ8.47 (dd, J = 4.8, 2.1Hz, 1H), 8.15 (dd, J = 7.8, 2.1Hz, 1H), 7.95 (s, 1H),
7.84 (s, 1H), 7.79 (s, 1H), 7.73 (d, J = 1.5Hz, 1H),
7.59 (d, J = 8.1Hz, 1H), 7.55 (dd, J = 8.1, 1.5Hz, 1H),
7.35 (dd, J = 7.8, 4.8Hz, 1H), 7.10 (t, J = 6.0Hz, 1H),
4.76 (d, J = 6.0Hz, 2H), 4.11 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H).
2-535 δ8.45-8.55 (m, 1H), 8.1-8.2 (m, 2H), 8.03 (s, 1H), 7.82 (s, 1H),
7.74 (s, 1H), 7.5-7.7 (m, 2H), 7.3-7.4 (m, 1H), 7.10 (bs, 1H),
4.77 (d, J = 6.3Hz, 2H), 4.11 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H).
2-536 δ8.45-8.5 (m, 1H), 8.15-8.2 (m, 1H), 7.91 (s, 1H), 7.80 (s, 1H),
7.75 (s, 1H), 7.69 (s, 1H), 7.61 (s, 2H), 7.3-7.4 (m, 1H),
7.14 (bs, 1H), 4.76 (d, J = 6.0Hz, 2H), 4.11 (d, J = 17.4Hz, 1H),
3.70 (d, J = 17.4Hz, 1H).
2-537 δ8.11 (s, 1H), 7.81 (s, 1H), 7.74 (s, 1H), 7.69 (s, 1H),
7.62 (d, J = 8.1Hz, 1H), 7.43 (d, J = 8.1Hz, 1H), 5.92 (bs, 1H),
4.47 (d, J = 6.0Hz, 2H), 4.09 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
2.04 (s, 3H).
2-539 δ8.11 (s, 1H), 7.80 (s, 1H), 7.74 (s, 1H), 7.68 (s, 1H),
7.61 (d, J = 8.1Hz, 1H), 7.42 (d, J = 8.1Hz, 1H), 5.94 (bs, 1H),
4.47 (d, J = 6.0Hz, 2H), 4.09 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
2.26 (q, J = 7.5Hz, 2H), 1.18 (t, J = 7.5Hz, 3H).
3-003 δ7.63 (d, J = 8.1Hz, 2H), 7.51 (s, 2H), 7.42 (s, 1H),
7.33 (d, J = 8.1Hz, 2H), 5.19 (bs, 1H), 4.3-4.5 (m, 3H),
3.69 (d, J = 17.4Hz, 1H), 3.6-3.8 (m, 4H).
3-006 δ8.26 (s, 1H), 7.97 (d, J = 8.1Hz, 1H), 7.75 (d, J = 8.1Hz, 1H),
7.64 (s, 2H), 5.31 (t, J = 6.0Hz, 1H), 4.60 (d, J = 6.0Hz, 2H),
4.11 (d, J = 17.4Hz, 1H), 3.71 (d, J = 17.4Hz, 1H), 1.42 (s, 9H).
3-007 δ7.4-7.7 (m, 5H), 5.49 (t, J = 6.3Hz, 1H), 4.4-4.55 (m, 4H),
4.06 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H).
3-008 δ7.85 (s, 1H), 7.35-7.6 (m, 5H), 5.55 (t, J = 6.9Hz, 1H),
4.4-4.55 (m, 4H), 4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H).
3-009 δ7.65 (d, J = 8.4Hz, 2H), 7.64 (s, 2H), 7.36 (d, J = 8.4Hz, 2H),
5.38 (d, J = 7.8Hz, 1H), 4.8-4.9 (m, 1H), 4.35-4.5 (m, 2H),
4.07 (d, J = 17.1Hz, 1H), 3.67 (d, J = 17.1Hz, 1H), 1.50 (d, J = 7.2Hz, 3H).
3-010 δ7.55-7.7 (m, 3H), 7.4-7.55 (m, 2H), 5.39 (d, J = 6.0Hz, 1H),
4.69 (d, J = 2.4Hz, 2H), 4.47 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.3Hz, 1H),
3.67 (d, J = 17.3Hz, 1H), 2.48 (t, J = 2.4Hz, 1H).
3-011 δ7.67 (s, 1H), 7.63 (s, 2H), 7.4-7.55 (m, 2H), 5.92 (bs, 1H),
4.56 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H),
2.34 (s, 3H).
3-012 δ7.67 (s, 1H), 7.63 (s, 2H), 7.4-7.55 (m, 2H), 5.93 (bs, 1H),
4.55 (d, J = 6.3Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
2.92 (q, J = 7.5Hz, 2H), 1.29 (t, J = 7.5Hz, 3H).
3-013 δ8.08 (s, 2H), 7.98 (s, 1H), 7.88 (d, J = 1.8Hz, 1H), 7.55-7.65 (m, 1H),
7.45-7.55 (m, 1H), 5.89 (t, J = 6.0Hz, 1H), 4.56 (d, J = 6.0Hz, 2H),
4.17 (d, J = 17.4Hz, 1H), 3.73 (d, J = 17.4Hz, 1H), 2.37 (s, 3H).
3-014 δ8.09 (s, 2H), 7.96 (s, 1H), 7.65 (d, J = 8.4Hz, 2H),
7.37 (d, J = 8.4Hz, 2H), 4.7-4.9 (m, 2H), 4.19 (d, J = 17.4Hz, 1H),
3.74 (d, J = 17.4Hz, 1H), 1.41 (bs, 12H).
3-015 δ8.08 (s, 2H), 7.95 (s, 1H), 7.64 (d, J = 8.4Hz, 2H),
7.36 (d, J = 8.4Hz, 2H), 4.85 (bs, 1H), 4.79 (bs, 1H),
4.19 (d, J = 17.1Hz, 1H), 3.74 (d, J = 17.1Hz, 1H), 1.41 (bs, 12H).
4-002 δ7.62 (d, J = 8.1Hz, 2H), 7.51 (d, J = 1.5Hz, 2H), 7.42 (t, J = 1.5Hz, 1H),
7.36 (d, J = 8.1Hz, 2H), 4.8-4.9 (m, 1H), 4.66 (d, J = 5.7Hz, 1H),
4.27 (bs, 1H), 4.07 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H),
3.1-3.25 (m, 2H), 1.44 (d, J = 6.9Hz, 3H), 1.07 (d, J = 6.9Hz, 3H).
4-003 δ7.60 (d, J = 8.1Hz, 2H), 7.50 (d, J = 1.5Hz, 2H), 7.42 (t, J = 1.5Hz, 1H),
7.36 (d, J = 8.1Hz, 2H), 4.75-4.85 (m, 2H), 4.25-4.35 (m, 1H),
4.06 (d, J = 17.4Hz, 1H), 3.75-3.9 (m, 1H), 3.68 (d, J = 17.4Hz, 1H),
1.41 (d, J = 6.3Hz, 3H), 1.08 and 1.06 (d, J = 6.3Hz, 6H).
4-004 δ7.63 (d, J = 8.1Hz, 2H), 7.50 (d, J = 1.5Hz, 2H), 7.42 (t, J = 1.5Hz, 1H),
7.38 (d, J = 8.1Hz, 2H), 4.8-4.9 (m, 1H), 4.65-4.75 (m, 2H),
4.07 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H), 3.55-3.6 (m, 2H),
3.45-3.55 (m, 2H), 1.46 (d, J = 6.9Hz, 3H).
4-007 δ7.69 (d, J = 1.5Hz, 1H), 7.52 (dd, J = 8.1, 1.5Hz, 1H), 7.45-7.55 (m, 3H),
7.42 (t, J = 1.5Hz, 1H), 7.10 (s, 1H), 6.20 (t, J = 6.3Hz, 1H),
4.57 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.71 (s, 3H),
3.66 (d, J = 17.4Hz, 1H).
4-009 δ7.89 (s, 1H), 7.4-7.55 (m, 4H), 7.12 (d, J = 8.1Hz, 1H),
5.97 (t, J = 6.0Hz, 1H), 5.87 (t, J = 6.0Hz, 1H), 4.05-4.3 (m, 2H),
4.07 (d, J = 17.4Hz, 1H), 3.65-3.85 (m, 2H), 3.68 (d, J = 17.4Hz, 1H).
4-011 δ7.69 (d, J = 1.5Hz, 1H), 7.45-7.55 (m, 4H), 7.42 (t, J = 1.5Hz, 1H),
4.96 (t, J = 6.3Hz, 1H), 4.50 (d, J = 6.3Hz, 2H), 4.04 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 2.92 (s, 6H).
4-012 δ7.68 (s, 1H), 7.4-7.55 (m, 5H), 5.57 (bs, 1H), 4.82 (bs, 1H),
4.53 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H),
2.35-2.5 (m, 1H), 0.7-0.8 (m, 2H), 0.5-0.65 (m, 2H).
4-013 δ7.69 (d, J = 1.5Hz, 1H), 7.45-7.55 (m, 4H), 7.43 (t, J = 1.5Hz, 1H),
5.01 (bs, 1H), 4.68 (bs, 1H), 4.50 (d, J = 6.3Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.85-3.95 (m, 2H), 3.68 (d, J = 17.4Hz, 1H).
4-014 δ7.2-7.55 (m, 6H), 6.14 (bs, 1H), 5.19 (bs, 2H), 4.22 (s, 2H),
4.03 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H).
4-015 δ7.25-7.65 (m, 5H), 5.70 (bs, 1H), 5.26 (bs, 1H), 4.28 (d, J = 6.3Hz, 2H),
4.04 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H), 3.14 (t, J = 6.8Hz, 2H),
1.04 (t, J = 6.8Hz, 3H).
4-016 δ7.63 (s, 1H), 7.2-7.5 (m, 5H), 5.75 (t, J = 6.0Hz, 1H),
5.30 (t, J = 7.2Hz, 1H), 4.23 (d, J = 6.6Hz, 2H), 4.04 (d, J = 17.7Hz, 1H),
3.67 (d, J = 17.7Hz, 1H), 3.14 (qui, J = 7.2Hz, 2H), 1.06 (t, J = 7.2Hz, 3H).
4-017 δ7.63 (s, 2H), 7.59 (d, J = 8.4Hz, 2H), 7.35 (d, J = 2.4Hz, 2H),
4.75-4.85 (m, 2H), 4.42 (t, J = 6.0Hz, 1H), 4.06 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 3.1-3.2 (m, 2H), 1.42 (d, J = 6.6Hz, 3H),
1.06 (t, J = 7.2Hz, 3H).
4-018 δ7.66 (s, 1H), 7.63 (s, 2H), 7.45-7.55 (m, 2H), 4.93 (t, J = 6.0Hz, 1H),
4.50 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H),
3.26 (q, J = 7.2Hz, 4H), 1.14 (t, J = 7.2Hz, 6H).
4-019 δ8.24 (s, 1H), 7.89 (d, J = 8.4Hz, 1H), 7.79 (d, J = 8.4Hz, 1H),
7.63 (s, 2H), 5.27 (t, J = 6.0Hz, 1H), 4.66 (d, J = 6.0Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H), 3.24 (q, J = 7.2Hz, 4H),
1.12 (t, J = 7.2Hz, 6H).
4-020 δ7.6-7.7 (m, 3H), 7.50 (s, 2H), 4.69 (t, J = 6.3Hz, 1H),
4.47 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.3Hz, 1H), 3.75-3.95 (m, 1H),
3.65 (d, J = 17.3Hz, 1H), 1.14 (d, J = 6.6Hz, 6H).
4-021 δ7.4-7.6 (m, 5H), 7.2-7.3 (m, 1H), 5.72 (t, J = 6.0Hz, 1H),
5.14 (d, J = 7.8Hz, 1H), 4.1-4.25 (m, 2H), 4.04 (d, J = 17.7Hz, 1H),
3.7-3.85 (m, 1H), 3.67 (d, J = 17.7Hz, 1H), 1.08 (d, J = 6.6Hz, 6H).
4-022 δ7.65 (s, 2H), 7.60 (d, J = 8.1Hz, 2H), 7.35 (d, J = 8.1Hz, 2H),
4.8-4.9 (m, 1H), 4.75 (d, J = 7.2Hz, 1H), 4.25 (d, J = 7.8Hz, 1H),
4.05 (d, J = 17.1Hz, 1H), 3.75-3.85 (m, 1H), 3.65 (d, J = 17.1Hz, 1H),
1.40 (d, J = 6.6Hz, 3H), 1.10 (d, J = 6.0Hz, 3H), 1.05 (d, J = 6.0Hz, 3H).
4-023 δ8.07 (s, 2H), 7.96 (s, 1H), 7.68 (d, J = 1.5Hz, 1H), 7.45-7.55 (m, 2H),
5.62 (t, J = 1.5Hz, 1H), 4.91 (bs, 1H), 4.52 (d, J = 6.0Hz, 2H),
4.17 (d, J = 17.4Hz, 1H), 3.73 (d, J = 17.4Hz, 1H), 2.4-2.5 (m, 1H),
0.7-0.8 (m, 2H), 0.55-0.65 (m, 2H).
4-025 δ7.85 (d, J = 1.5Hz, 1H), 7.63 (s, 2H), 7.55 (dd, J = 8.1, 1.5Hz, 1H),
7.48 (d, J = 8.1Hz, 1H), 5.62 (t, J = 6.2Hz, 1H), 4.77 (s, 1H),
4.50 (d, J = 6.2Hz, 2H), 4.05 (d, J = 17.1Hz, 1H), 3.65 (d, J = 17.1Hz, 1H),
2.4-2.55 (m, 1H), 0.7-0.85 (m, 2H), 0.55-0.65 (m, 2H).
4-027 δ8.09 (s, 1H), 7.96 (s, 2H), 7.65 (d, J = 8.4Hz, 2H),
7.41 (d, J = 8.4Hz, 2H), 5.21 (bs, 1H), 5.02 (bs, 1H), 4.69 (bs, 1H),
4.19 (d, J = 17.4Hz, 1H), 3.73 (d, J = 17.4Hz, 1H), 2.4-2.5 (m, 1H),
1.51 (d, J = 7.2Hz, 3H), 0.7-0.8 (m, 2H), 0.55-0.6 (m, 2H).
4-028 δ7.65 (s, 2H), 7.60 (d, J = 8.4Hz, 2H), 7.40 (d, J = 8.4Hz, 2H),
5.25 (d, J = 7.5Hz, 1H), 4.95-5.05 (m, 1H), 4.80 (bs, 1H),
4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H), 2.4-2.5 (m, 1H),
1.50 (d, J = 6.9Hz, 3H), 0.7-0.8 (m, 2H), 0.55-0.6 (m, 2H).
4-029 δ7.63 (s, 2H), 7.45-7.5 (m, 1H), 7.35-7.4 (m, 1H), 7.25-7.3 (m, 1H),
5.68 (bs, 1H), 5.29 (bs, 1H), 4.28 (d, J = 5.4Hz, 2H),
4.04 (d, J = 17.3Hz, 1H), 3.66 (d, J = 17.3Hz, 1H), 2.92 (t, J = 6.6Hz, 2H),
1.65 (sep, J = 6.6Hz, 1H), 0.83 (d, J = 6.6Hz, 6H).
4-030 δ7.15-7.5 (m, 6H), 5.75 (bs, 1H), 5.39 (bs, 1H), 4.30 (s, 2H),
4.04 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H), 2.99 (t, J = 5.6Hz, 2H),
0.8-0.95 (m, 1H), 0.35-0.45 (m, 2H), 0.05-0.15 (m, 2H).
4-031 δ7.63 (s, 2H), 7.5-7.55 (m, 1H), 7.3-7.45 (m, 2H), 5.40 (bs, 1H),
5.05 (bs, 1H), 4.37 (d, J = 5.7Hz, 2H), 4.05 (d, J = 17.3Hz, 1H),
3.66 (d, J = 17.3Hz, 1H), 3.01 (t, J = 6.0Hz, 2H), 0.8-0.95 (m, 1H),
0.4-0.5 (m, 2H), 0.05-0.15 (m, 2H).
4-032 δ7.5-7.65 (m, 3H), 7.3-7.5 (m, 2H), 5.13 (bs, 1H), 4.92 (bs, 1H),
4.3-4.45 (m, 2H), 4.04 (d, J = 17.3Hz, 1H), 4.11 (qui, J = 10.3Hz, 1H),
3.65 (d, J = 17.3Hz, 1H), 2.2-2.35 (m, 2H), 1.55-1.9 (m, 4H).
4-033 δ7.55-7.65 (m, 3H), 7.50 (s, 2H), 4.78 (t, J = 6.3Hz, 1H),
4.48 (d, J = 6.3Hz, 2H), 4.36 (t, J = 6.3Hz, 1H), 4.05 (d, J = 17.3Hz, 1H),
3.65 (d, J = 17.3Hz, 1H), 2.97 (d, J = 6.3Hz, 2H), 0.89 (s, 9H).
4-034 δ7.65-7.7 (m, 3H), 7.4-7.5 (m, 2H), 5.10 (t, J = 6.3Hz, 1H),
4.63 (d, J = 6.3Hz, 1H), 4.41 (d, J = 6.3Hz, 2H), 4.04 (d, J = 17.3Hz, 1H),
3.93 (qui, J = 6.8Hz, 1H), 3.65 (d, J = 17.3Hz, 1H), 1.85-2.0 (m, 2H),
1.5-1.65 (m, 4H), 1.2-1.4 (m, 2H).
4-035 δ7.64 (s, 2H), 7.61 (d, J = 8.4Hz, 2H), 7.40 (d, J = 8.4Hz, 2H),
4.6-5.0 (m, 3H), 4.06 (d, J = 17.1Hz, 1H), 3.4-3.75 (m, 5H),
1.46 (d, J = 6.3Hz, 3H).
4-036 δ7.15-7.7 (m, 5H), 5.7-6.15 (m, 2H), 4.27 (d, J = 6.3Hz, 2H),
4.04 (d, J = 17.3Hz, 1H), 3.65-3.85 (m, 2H), 3.66 (d, J = 17.3Hz, 1H).
4-039 δ7.64 (d, J = 1.5Hz, 2H), 7.56 (d, J = 8.1Hz, 2H),
7.26 (dd, J = 8.4, 2.4Hz, 2H), 5.65 (d, J = 7.2Hz, 1H), 5.5-5.55 (m, 1H),
4.75-4.9 (m, 1H), 4.05 (d, J = 17.4Hz, 1H), 3.6-3.75 (m, 3H),
1.35 (d, J = 6.9Hz, 3H).
4-040 δ7.63 (s, 2H), 7.56 (s, 1H), 7.35-7.45 (m, 2H), 5.72 (bs, 1H),
5.38 (bs, 1H), 4.38 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.3Hz, 1H),
3.67 (d, J = 17.3Hz, 1H), 3.43 (t, J = 5.1Hz, 2H), 3.34 (t, J = 5.1Hz, 2H),
3.32 (s, 3H).
4-041 δ7.45-7.7 (m, 5H), 4.85 (bs, 1H), 4.77 (bs, 1H), 4.48 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H), 3.41 (q, J = 6.0Hz, 2H),
2.63 (t, J = 6.0Hz, 2H), 2.09 (s, 3H).
4-043 δ7.35-7.6 (m, 5H), 5.46 (bs, 1H), 5.30 (bs, 1H), 4.38 (d, J = 6.0Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H), 3.35 (q, J = 6.3Hz, 2H),
2.61 (t, J = 6.3Hz, 2H), 2.50 (q, J = 7.1Hz, 2H), 1.22 (t, J = 7.1Hz, 3H).
4-044 δ7.63 (s, 2H), 7.52 (s, 1H), 7.3-7.45 (m, 2H), 5.75-5.9 (m, 2H),
4.33 (d, J = 6.3Hz, 2H), 4.06 (d, J = 17.3Hz, 1H), 3.69 (d, J = 17.3Hz, 1H),
3.64 (t, J = 6.0Hz, 2H), 3.16 (t, J = 6.0Hz, 2H), 3.00 (q, J = 7.4Hz, 2H),
1.34 (t, J = 7.4Hz, 3H).
4-045 δ7.55-7.65 (m, 3H), 7.4-7.5 (m, 2H), 7.28 (bs, 1H), 5.64 (bs, 1H),
4.40 (d, J = 4.5Hz, 2H), 4.05 (d, J = 17.3Hz, 1H), 3.66 (d, J = 17.3Hz, 1H),
3.26 (d, J = 5.1Hz, 2H), 2.47 (t, J = 5.1Hz, 2H), 2.25 (s, 6H).
4-047 δ7.63 (s, 2H), 7.56 (s, 1H), 7.35-7.5 (m, 2H), 5.59 (t, J = 6.0Hz, 1H),
5.47 (t, J = 5.7Hz, 1H), 4.39 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.4Hz, 1H),
3.96 (d, J = 5.7Hz, 2H), 3.71 (s, 3H), 3.66 (d, J = 17.4Hz, 1H).
4-048 δ7.64 (s, 2H), 7.5-7.55 (m, 1H), 7.3-7.45 (m, 2H), 5.85 (bs, 1H),
5.71 (bs, 1H), 4.35 (d, J = 6.0Hz, 2H), 4.14 (q, J = 7.2Hz, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.93 (d, J = 5.4Hz, 2H), 3.67 (d, J = 17.4Hz, 1H),
1.24 (t, J = 7.2Hz, 3H).
4-049 δ7.68 (t, J = 6.0Hz, 1H), 7.63 (s, 2H), 7.61 (d, J = 1.5Hz, 1H),
7.41 (dd, J = 8.4, 1.5Hz, 1H), 7.19 (d, J = 8.4Hz, 1H),
6.16 (t, J = 6.0Hz, 1H), 5.94 (t, J = 6.0Hz, 1H), 4.23 (d, J = 6.0Hz, 2H),
4.02 (d, J = 17.1Hz, 1H), 4.00 (d, J = 6.0Hz, 2H), 3.75-3.9 (m, 2H),
3.64 (d, J = 17.1Hz, 1H).
4-050 δ7.55-7.65 (m, 3H), 7.51 (s, 2H), 4.95 (bs, 1H), 4.50 (d, J = 6.3Hz, 2H),
4.10 (bs, 1H), 4.05 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H),
2.56 (d, J = 4.8Hz, 2H), 0.08 (s, 9H).
4-051 δ7.63 (s, 2H), 7.45-7.55 (m, 1H), 7.35-7.45 (m, 1H), 7.25-7.35 (m, 1H),
5.65-5.85 (m, 2H), 5.35 (bs, 1H), 5.0-5.2 (m, 2H), 4.29 (s, 2H),
4.04 (d, J = 17.3Hz, 1H), 3.65-3.75 (m, 2H), 3.66 (d, J = 17.3Hz, 1H).
4-052 δ7.45-7.75 (m, 6H), 6.48 (t, J = 6.0Hz, 1H), 6.33 (t, J = 6.0Hz, 1H),
4.41 (d, J = 6.0Hz, 2H), 4.18 (d, J = 17.3Hz, 1H), 3.93 (d, J = 17.3Hz, 1H),
3.9-3.95 (m, 2H), 2.43 (s, 1H).
4-053 (DMSO-d ₆ , Me _Four Si, 300MHz) δ7.6-7.8 (m, 4H), 7.35-7.45 (m, 1H),
6.59 (t, J = 6.3Hz, 1H), 6.45 (t, J = 6.0Hz, 1H), 4.2-4.4 (m, 4H),
3.83 (dd, J = 6.0, 2.4Hz, 2H), 2.92 (d, J = 2.4Hz, 1H).
4-055 δ7.61 (s, 2H), 7.57 (d, J = 8.1Hz, 2H), 7.32 (d, J = 8.1Hz, 2H),
5.30 (d, J = 7.2Hz, 1H), 5.05 (t, J = 5.4Hz, 1H), 4.8-4.9 (m, 1H),
4.06 (d, J = 17.4Hz, 1H), 3.85-3.95 (m, 2H), 3.67 (d, J = 17.4Hz, 1H),
2.18 (t, J = 2.4Hz, 1H), 1.40 (d, J = 6.6Hz, 3H).
4-056 δ7.63 (s, 3H), 7.47 (d, J = 6.0Hz, 2H), 5.25 (t, J = 6.0Hz, 1H),
4.49 (d, J = 6.0Hz, 2H), 4.10 (d, J = 2.4Hz, 2H), 4.05 (d, J = 17.3Hz, 1H),
3.67 (d, J = 17.3Hz, 1H), 2.97 (s, 3H), 2.26 (t, J = 2.4Hz, 1H).
4-057 δ7.63 (s, 2H), 7.0-7.45 (m, 8H), 5.89 (bs, 2H), 4.0-4.2 (m, 4H),
3.98 (d, J = 17.3Hz, 1H), 3.59 (d, J = 17.3Hz, 1H).
4-058 δ7.64 (s, 2H), 7.58 (d, J = 8.4Hz, 2H), 7.15-7.35 (m, 7H),
4.8-4.95 (m, 1H), 4.76 (d, J = 6.6Hz, 1H), 4.71 (t, J = 5.7Hz, 1H),
4.33 (dd, J = 15.0, 5.7Hz, 1H), 4.27 (dd, J = 15.0, 5.7Hz, 1H),
4.05 (d, J = 17.1Hz, 1H), 3.65 (d, J = 17.1Hz, 1H), 1.40 (d, J = 6.6Hz, 3H).
4-062 δ7.6-7.7 (m, 3H), 7.4-7.5 (m, 2H), 7.15-7.3 (m, 4H),
4.94 (t, J = 6.3Hz, 1H), 4.80 (t, J = 6.0Hz, 1H), 4.45 (d, J = 6.3Hz, 2H),
4.31 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H).
4-063 δ7.3-7.65 (m, 9H), 5.15 (t, J = 6.0Hz, 1H), 5.04 (t, J = 6.0Hz, 1H),
4.89 (d, J = 6.0Hz, 2H), 4.40 (d, J = 6.0Hz, 2H), 4.03 (d, J = 17.3Hz, 1H),
3.64 (d, J = 17.3Hz, 1H).
4-064 δ7.64 (s, 2H), 7.52 (s, 1H), 7.25-7.5 (m, 6H), 5.3-5.45 (m, 2H),
4.35 (d, J = 5.7Hz, 2H), 4.32 (d, J = 5.7Hz, 2H), 4.08 (d, J = 17.3Hz, 1H),
3.64 (d, J = 17.3Hz, 1H).
4-065 δ7.62 (s, 2H), 7.25-7.45 (m, 4H), 7.05-7.2 (m, 3H), 6.00 (bs, 1H),
5.83 (bs, 1H), 4.05-4.2 (m, 4H), 3.99 (d, J = 17.3Hz, 1H),
3.62 (d, J = 17.3Hz, 1H).
4-066 δ7.55-7.7 (m, 3H), 7.35-7.5 (m, 2H), 6.04 (d, J = 3.3Hz, 1H),
5.84 (dd, J = 3.3, 1.2Hz, 1H), 5.18 (t, J = 6.0Hz, 1H),
4.97 (t, J = 5.7Hz, 1H), 4.41 (d, J = 6.0Hz, 2H), 4.25 (d, J = 5.7Hz, 2H),
4.04 (d, J = 17.3Hz, 1H), 3.64 (d, J = 17.3Hz, 1H), 2.21 (s, 3H).
4-067 δ7.3-7.7 (m, 5H), 7.1-7.2 (m, 1H), 6.8-6.95 (m, 2H), 5.42 (bs, 2H),
4.25-4.5 (m, 4H), 4.03 (d, J = 17.3Hz, 1H), 3.64 (d, J = 17.3Hz, 1H).
4-069 δ8.45 (d, J = 4.5Hz, 1H), 7.70 (s, 2H), 7.55-7.7 (m, 3H), 7.42 (s, 2H),
7.1-7.3 (m, 1H), 6.07 (bs, 1H), 5.93 (bs, 1H), 4.45-4.5 (m, 4H),
4.03 (d, J = 17.3Hz, 1H), 3.64 (d, J = 17.3Hz, 1H).
4-070 δ8.45 (d, J = 4.8Hz, 1H), 7.55-7.75 (m, 5H), 7.37 (d, J = 8.1Hz, 2H),
7.1-7.3 (m, 2H), 5.68 (t, J = 4.8Hz, 1H), 5.38 (bs, 1H), 4.8-5.0 (m, 1H),
4.66 (dd, J = 16.7, 4.8Hz, 1H), 4.40 (dd, J = 16.7, 4.8Hz, 1H),
4.06 (d, J = 17.2Hz, 1H), 3.66 (d, J = 17.2Hz, 1H), 1.43 (d, J = 6.9Hz, 3H).
4-071 δ8.38 (bs, 1H), 7.5-7.7 (m, 4H), 7.1-7.4 (m, 3H), 7.14 (s, 1H),
5.85-6.2 (m, 2H), 4.33 (d, J = 5.1Hz, 2H), 4.27 (bs, 2H),
4.03 (d, J = 17.3Hz, 1H), 3.66 (d, J = 17.3Hz, 1H).
4-072 δ8.42 (d, J = 5.4Hz, 1H), 7.55-7.7 (m, 4H), 7.3-7.45 (m, 2H),
7.05-7.2 (m, 2H), 5.77 (t, J = 6.3Hz, 2H), 4.39 (d, J = 6.3Hz, 2H),
4.30 (d, J = 5.7Hz, 2H), 4.04 (d, J = 17.3Hz, 1H), 3.66 (d, J = 17.3Hz, 1H).
4-074 δ7.6-7.7 (m, 3H), 7.45-7.55 (m, 2H), 4.79 (t, J = 6.0Hz, 1H),
4.51 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H),
3.34 (t, J = 6.6Hz, 4H), 1.8-2.0 (m, 4H).
4-075 δ7.63 (s, 2H), 7.60 (d, J = 8.4Hz, 2H), 7.40 (d, J = 8.4Hz, 2H),
5.0-5.1 (m, 1H), 4.41 (d, J = 7.2Hz, 1H), 4.06 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 3.3-3.35 (m, 4H), 1.85-1.95 (m, 4H),
1.48 (d, J = 6.9Hz, 3H).
4-076 δ7.63 (s, 3H), 7.48 (s, 2H), 5.11 (t, J = 6.0Hz, 1H), 4.4-4.6 (m, 3H),
4.05 (d, J = 17.4Hz, 1H), 3.72 (s, 3H), 3.66 (d, J = 17.4Hz, 1H),
3.45-3.55 (m, 1H), 3.35-3.45 (m, 1H), 1.95-2.2 (m, 4H).
4-077 δ7.6-7.7 (m, 3H), 7.55-7.65 (m, 2H), 6.99 (bs, 1H),
5.11 (t, J = 6.0Hz, 1H), 4.35-4.65 (m, 3H), 4.06 (d, J = 17.4Hz, 1H),
3.67 (d, J = 17.4Hz, 1H), 3.43 (dt, J = 8.1, 2.7Hz, 1H),
3.29 (q, J = 2.7Hz, 1H), 2.76 (d, J = 4.8Hz, 3H), 2.25-2.35 (m, 1H),
1.8-2.15 (m, 3H).
4-078 δ7.6-7.7 (m, 3H), 7.48 (s, 2H), 5.05 (t, J = 6.0Hz, 1H),
4.49 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H),
3.3-3.4 (m, 4H), 1.45-1.7 (m, 6H).
4-080 δ7.77 (s, 1H), 7.35-7.5 (m, 5H), 5.09 (bs, 1H), 4.49 (d, J = 5.7Hz, 2H),
4.46 (s, 2H), 4.04 (d, J = 17.3Hz, 1H), 3.66 (d, J = 17.3Hz, 1H),
3.66 (t, J = 6.3Hz, 2H), 3.04 (t, J = 6.3Hz, 2H).
4-081 δ7.6-7.75 (m, 3H), 7.49 (s, 2H), 4.98 (t, J = 6.0Hz, 1H),
4.51 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.3Hz, 1H), 3.68 (t, J = 4.8Hz, 4H),
3.64 (d, J = 17.3Hz, 1H), 2.60 (t, J = 4.8Hz, 4H).
4-082 δ7.67 (s, 1H), 7.63 (s, 2H), 7.35-7.6 (m, 2H), 5.42 and 5.33 (bs, 1H),
5.45-5.55 (m, 2H), 4.05 (d, J = 17.4Hz, 1H), 4.8-4.95 (m, 4H),
3.65 (d, J = 17.4Hz, 1H), 2.65-2.85 (m, 4H).
4-083 δ7.35-7.7 (m, 5H), 5.32 (bs, 1H), 4.51 (d, J = 5.7Hz, 2H),
4.04 (d, J = 17.4Hz, 1H), 3.89 (t, J = 5.1Hz, 4H), 3.64 (d, J = 17.4Hz, 1H),
3.03 (t, J = 5.1Hz, 4H).
4-084 δ7.63 (s, 2H), 7.60 (d, J = 8.7Hz, 2H), 7.37 (d, J = 8.7Hz, 2H),
4.5-5.05 (m, 1H), 4.68 (d, J = 6.6Hz, 1H), 4.07 (d, J = 17.1Hz, 1H),
3.6-3.75 (m, 5H), 2.55-2.6 (m, 4H), 1.47 (d, J = 7.2Hz, 3H).
4-085 δ7.64 (s, 2H), 7.61 (d, J = 8.4Hz, 2H), 7.40 (d, J = 8.4Hz, 2H),
7.2-7.35 (m, 3H), 6.85-6.95 (m, 2H), 4.95-5.05 (m, 1H),
4.69 (d, J = 6.9Hz, 1H), 4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
3.56 (t, J = 4.5Hz, 4H), 3.18 (t, J = 5.1Hz, 4H), 1.50 (d, J = 6.9Hz, 3H).
4-086 δ7.58 (d, J = 1.2Hz, 1H), 7.55 (s, 2H), 7.35-7.5 (m, 2H),
4.51 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.4Hz, 1H), 3.97 (t, J = 7.2Hz, 2H),
3.67 (d, J = 17.4Hz, 1H), 2.55 (t, J = 8.1Hz, 2H),
1.98 (tt, J = 8.1, 7.2Hz, 2H).
4-087 δ7.72 (d, J = 1.8Hz, 1H), 7.63 (s, 2H), 7.52 (dd, J = 8.4, 1.8Hz, 1H),
7.16 (d, J = 8.4Hz, 1H), 6.65 (s, 1H), 4.90 (s, 2H),
4.07 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H), 1.90 (s, 3H).
4-088 δ8.33 (t, J = 2.7Hz, 1H), 7.67 (s, 1H), 7.4-7.55 (m, 5H),
4.59 (d, J = 6.0Hz, 2H), 4.45 (t, J = 8.1Hz, 2H), 4.06 (t, J = 8.1Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.68 (d, J = 17.3Hz, 1H).
4-089 δ7.55-7.7 (m, 4H), 7.4-7.55 (m, 2H), 4.56 (d, J = 6.0Hz, 2H),
4.26 (t, J = 6.9Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H),
3.17 (t, J = 6.9Hz, 2H).
4-090 δ7.61 (s, 3H), 7.0-7.45 (m, 7H), 6.8-6.95 (m, 1H), 6.22 (bs, 1H),
4.15-4.3 (m, 2H), 3.95 (d, J = 17.3Hz, 1H), 3.55 (d, J = 17.3Hz, 1H).
4-093 δ7.55-7.65 (m, 3H), 7.4-7.5 (m, 7H), 5.00 (t, J = 6.3Hz, 1H),
4.44 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H).
4-094 δ7.55-7.65 (m, 3H), 7.3-7.5 (m, 4H), 7.04 (s, 1H),
6.69 (d, J = 8.0Hz, 2H), 5.61 (t, J = 6.3Hz, 1H), 4.46 (d, J = 6.3Hz, 2H),
4.02 (d, J = 17.3Hz, 1H), 3.63 (d, J = 17.3Hz, 1H).
4-096 δ7.4-7.7 (m, 6H), 6.24 (bs, 1H), 4.55 (d, J = 6.6Hz, 2H),
4.05 (d, J = 17.3Hz, 1H), 3.70 (s, 3H), 3.67 (d, J = 17.3Hz, 1H).
4-097 δ7.6-7.7 (m, 3H), 7.4-7.5 (m, 2H), 6.32 (t, J = 6.3Hz, 1H),
4.51 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.3Hz, 1H), 3.67 (s, 3H),
3.65 (d, J = 17.3Hz, 1H), 3.10 (s, 3H).
4-098 δ7.69 (d, J = 1.5Hz, 1H), 7.4-7.55 (m, 5H), 7.13 (bs, 1H),
6.24 (t, J = 6.3Hz, 1H), 4.57 (d, J = 6.3Hz, 2H), 4.06 (d, J = 17.3Hz, 1H),
3.89 (q, J = 7.1Hz, 2H), 3.67 (d, J = 17.3Hz, 1H), 1.26 (t, J = 7.1Hz, 3H).
4-099 δ7.68 (d, J = 1.5Hz, 1H), 7.45-7.55 (m, 3H), 7.4-7.45 (m, 2H),
6.89 (t, J = 5.7Hz, 1H), 4.51 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.67 (d, J = 17.3Hz, 1H), 3.19 (s, 3H).
4-100 δ7.6-7.7 (m, 3H), 7.4-7.5 (m, 2H), 7.06 (bs, 1H), 6.6-6.7 (m, 1H),
5.21 (bs, 2H), 4.58 (d, J = 6.6Hz, 1H), 4.50 (d, J = 6.6Hz, 1H),
4.05 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H).
4-101 δ7.6-7.7 (m, 3H), 7.49 (s, 2H), 6.89 (bs, 1H), 4.49 (d, J = 6.8Hz, 2H),
4.04 (d, J = 17.3Hz, 1H), 3.64 (d, J = 17.3Hz, 1H), 3.55 (q, J = 7.1Hz, 2H),
1.15 (t, J = 7.1Hz, 3H).
4-102 δ7.6-7.7 (m, 3H), 7.4-7.55 (m, 2H), 7.13 (t, J = 6.3Hz, 1H),
4.46 (d, J = 6.3Hz, 2H), 4.05 (d, J = 17.3Hz, 1H), 3.66 (d, J = 17.3Hz, 1H),
3.58 (s, 2H), 1.47 (s, 9H).
4-103 δ7.6-7.7 (m, 3H), 7.45-7.55 (m, 2H), 7.2-7.4 (m, 5H),
7.00 (t, J = 6.3Hz, 1H), 4.69 (s, 2H), 4.53 (d, J = 6.3Hz, 2H),
4.06 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H), 3.47 (s, 2H).
4-104 δ7.67 (d, J = 3.0Hz, 1H), 7.4-7.55 (m, 5H), 6.57 (t, J = 6.0Hz, 1H),
5.18 (d, J = 6.0Hz, 1H), 4.53 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.3Hz, 1H),
3.67 (d, J = 17.3Hz, 1H), 2.49 (s, 6H).
4-105 δ7.6-7.7 (m, 3H), 7.4-7.55 (m, 2H), 6.58 (t, J = 6.3Hz, 1H),
5.30 (bs, 1H), 4.53 (d, J = 6.3Hz, 2H), 4.06 (d, J = 17.3Hz, 1H),
3.67 (d, J = 17.3Hz, 1H), 2.52 (s, 6H).
4-106 δ7.64 (s, 2H), 7.61 (d, J = 8.4Hz, 2H), 7.40 (d, J = 8.4Hz, 2H),
4.9-5.1 (m, 1H), 4.59 (d, J = 6.3Hz, 1H), 4.06 (d, J = 17.1Hz, 1H),
3.66 (d, J = 17.1Hz, 1H), 2.91 (s, 6H), 1.48 (d, J = 6.9Hz, 3H).
4-107 δ7.6-7.7 (m, 3H), 7.4-7.55 (m, 2H), 6.61 (t, J = 6.3Hz, 1H),
5.91 (bs, 1H), 4.53 (d, J = 6.3Hz, 2H), 4.06 (d, J = 17.3Hz, 1H),
3.66 (d, J = 17.3Hz, 1H), 3.31 (bs, 1H), 1.08 (s, 9H).
4-108 δ7.55-7.7 (m, 3H), 7.4-7.5 (m, 2H), 6.59 (t, J = 6.0Hz, 1H),
5.62 (bs, 1H), 4.51 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.3Hz, 1H),
3.68 (d, J = 17.3Hz, 1H), 2.1-3.05 (m, 8H), 2.29 (s, 3H).
4-110 δ8.39 (bs, 1H), 7.99 (bs, 1H), 7.62 (s, 2H), 7.51 (s, 1H),
7.25-7.45 (m, 2H), 6.29 (d, J = 6.0Hz, 1H), 4.39 (d, J = 6.0Hz, 2H),
4.02 (d, J = 17.3Hz, 1H), 3.64 (d, J = 17.3Hz, 1H), 2.19 (t, J = 7.4Hz, 2H),
1.63 (sxt, J = 7.4Hz, 2H), 0.91 (t, J = 7.4Hz, 3H).
4-111 δ8.65 (bs, 1H), 8.22 (bs, 1H), 7.62 (s, 2H), 7.50 (s, 1H),
7.2-7.4 (m, 2H), 6.44 (bs, 1H), 4.37 (d, J = 6.3Hz, 2H),
4.01 (d, J = 17.3Hz, 1H), 3.64 (d, J = 17.3Hz, 1H),
2.49 (sep, J = 6.8Hz, 1H), 1.11 (d, J = 6.8Hz, 6H).
4-113 δ8.07 (s, 2H), 7.96 (s, 1H), 7.67 (s, 1H), 7.45-7.55 (m, 2H),
6.48 (bs, 1H), 6.34 (bs, 1H), 5.81 (bs, 1H), 4.52 (d, J = 6.0Hz, 2H),
4.16 (d, J = 17.4Hz, 1H), 3.78 (s, 3H), 3.73 (d, J = 17.4Hz, 1H).
4-114 (CD _Three OD, Me _Four Si, 300MHz) δ7.7-7.8 (m, 3H), 7.63 (d, J = 8.4Hz, 1H),
7.49 (d, J = 8.4Hz, 1H), 4.59 (s, 1H), 4.45 (s, 2H),
4.25 (d, J = 18.0Hz, 1H), 3.99 (d, J = 18.0Hz, 1H), 3.74 (s, 3H).
4-116 δ7.6-7.65 (m, 3H), 7.4-7.5 (m, 2H), 5.07 (bs, 1H),
4.44 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H).
4-118 δ7.6-7.7 (m, 3H), 7.2-7.55 (m, 4H), 6.85-7.0 (m, 3H), 6.2-6.35 (m, 2H),
4.51 (d, J = 6.3Hz, 2H), 4.04 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H),
3.12 (s, 3H).
4-119 δ7.6-7.7 (m, 3H), 7.35-7.5 (m, 2H), 7.0-7.1 (m, 2H), 6.7-6.8 (m, 2H),
6.41 (t, J = 6.3Hz, 1H), 6.32 (bs, 1H), 5.68 (bs, 1H),
4.51 (d, J = 6.3Hz, 2H), 4.04 (d, J = 17.3Hz, 1H), 3.65 (d, J = 17.3Hz, 1H),
2.27 (s, 3H).
4-120 δ8.07 (s, 2H), 7.97 (s, 1H), 7.45 (d, J = 1.8Hz, 1H), 7.2-7.4 (m, 2H),
5.75 (bs, 1H), 5.31 (bs, 1H), 4.26 (d, J = 6.0Hz, 2H),
4.15 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H), 3.1-3.2 (m, 2H),
1.06 (t, J = 7.2Hz, 3H).
4-121 δ8.08 (s, 2H), 7.97 (s, 1H), 7.81 (d, J = 1.5Hz, 1H),
7.54 (dd, J = 8.1, 1.5Hz, 1H), 7.45 (d, J = 8.1Hz, 1H), 5.06 (bs, 1H),
4.45-4.7 (m, 1H), 4.41 (s, 2H), 4.16 (d, J = 17.1Hz, 1H),
3.71 (d, J = 17.1Hz, 1H), 3.20 (q, J = 7.2Hz, 2H), 1.12 (t, J = 7.2Hz, 3H).
4-122 δ8.08 (s, 2H), 7.96 (s, 1H), 7.64 (d, J = 8.4Hz, 2H),
7.39 (d, J = 8.4Hz, 2H), 4.8-4.9 (m, 1H), 4.58 (bs, 1H),
4.18 (d, J = 17.4Hz, 1H), 3.73 (d, J = 17.4Hz, 1H), 3.17 (q, J = 7.2Hz, 2H),
1.44 (d, J = 6.9Hz, 3H), 1.08 (t, J = 7.2Hz, 3H).
4-123 δ7.91 (d, J = 1.5Hz, 1H), 7.73 (dd, J = 8.4, 1.5Hz, 1H), 7.70 (s, 1H),
7.61 (d, J = 8.4Hz, 1H), 7.45-7.55 (m, 2H), 5.59 (t, J = 6.3Hz, 1H),
4.78 (s, 1H), 4.53 (d, J = 6.3Hz, 2H), 4.10 (d, J = 17.4Hz, 1H),
3.68 (d, J = 17.4Hz, 1H), 2.4-2.5 (m, 1H), 0.7-0.85 (m, 2H),
0.55-0.65 (m, 2H).
4-124 δ8.07 (s, 2H), 7.97 (s, 1H), 7.88 (d, J = 1.8Hz, 1H),
7.58 (dd, J = 8.1, 1.8Hz, 1H), 7.49 (d, J = 8.1Hz, 1H),
5.64 (t, J = 6.0Hz, 1H), 4.78 (bs, 1H), 4.51 (d, J = 6.3Hz, 2H),
4.16 (d, J = 17.1Hz, 1H), 3.71 (d, J = 17.1Hz, 1H), 2.4-2.55 (m, 1H),
0.7-0.85 (m, 2H), 0.55-0.65 (m, 2H).
4-127 δ8.17 (s, 2H), 8.06 (s, 1H), 7.61 (d, J = 1.5Hz, 1H), 7.35-7.5 (m, 2H),
5.32 (t, J = 6.0Hz, 1H), 4.99 (t, J = 5.4Hz, 1H), 4.43 (d, J = 6.0Hz, 2H),
4.16 (d, J = 17.4Hz, 1H), 3.96 (dd, J = 5.4, 2.4Hz, 2H),
3.72 (d, J = 17.4Hz, 1H), 2.21 (t, J = 2.4Hz, 1H).
4-128 δ8.07 (s, 2H), 7.97 (s, 1H), 7.76 (d, J = 1.5Hz, 1H),
7.52 (dd, J = 8.1, 1.5Hz, 1H), 7.38 (d, J = 8.1Hz, 1H),
5.46 (t, J = 6.0Hz, 1H), 5.13 (t, J = 5.4Hz, 1H), 4.37 (d, J = 6.0Hz, 2H),
4.16 (d, J = 17.1Hz, 1H), 3.96 (dd, J = 5.4, 2.4Hz, 2H),
3.72 (d, J = 17.1Hz, 1H), 2.20 (t, J = 2.4Hz, 1H).
4-129 δ8.08 (s, 2H), 7.96 (s, 1H), 7.64 (d, J = 8.4Hz, 2H),
7.39 (d, J = 8.4Hz, 2H), 4.85-4.95 (m, 1H), 4.75 (d, J = 6.6Hz, 1H),
4.48 (t, J = 5.7Hz, 1H), 4.18 (d, J = 17.1Hz, 1H),
3.95 (dd, J = 5.4, 2.4Hz, 2H), 3.73 (d, J = 17.1Hz, 1H),
2.21 (d, J = 2.4Hz, 1H), 1.45 (d, J = 6.9Hz, 3H).
4-130 δ8.07 (s, 2H), 7.96 (s, 1H), 7.25-7.45 (m, 3H), 5.35 (t, J = 5.4Hz, 1H),
4.93 (t, J = 6.0Hz, 1H), 4.36 (d, J = 6.0Hz, 2H), 4.15 (d, J = 17.4Hz, 1H),
3.72 (d, J = 17.4Hz, 1H), 3.16 (qd, J = 7.2, 5.4Hz, 2H),
1.08 (t, J = 7.2Hz, 3H).
4-131 δ7.95 (s, 1H), 7.84 (s, 1H), 7.79 (s, 1H), 7.66 (s, 1H), 7.49 (s, 2H),
4.86 (t, J = 6.0Hz, 1H), 4.46 (d, J = 6.0Hz, 2H), 4.37 (t, J = 6.0Hz, 1H),
4.10 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H), 3.15-3.25 (m, 2H),
1.13 (t, J = 7.2Hz, 3H).
4-132 δ7.76 (d, J = 5.4Hz, 2H), 7.55 (s, 1H), 7.3-7.45 (m, 2H), 5.39 (bs, 1H),
4.93 (bs, 1H), 4.34 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 3.17 (qd, J = 7.2, 5.4Hz, 2H),
1.09 (t, J = 7.2Hz, 3H).
4-133 δ7.82 (s, 2H), 7.57 (d, J = 1.5Hz, 1H), 7.35-7.5 (m, 2H),
5.29 (t, J = 6.3Hz, 1H), 4.83 (t, J = 5.4Hz, 1H), 4.38 (d, J = 6.3Hz, 2H),
4.03 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H),
3.18 (qd, J = 7.2, 5.4Hz, 2H), 1.10 (t, J = 7.2Hz, 3H).
4-134 δ7.94 (s, 1H), 7.84 (s, 1H), 7.58 (s, 1H), 7.45-7.55 (m, 2H),
5.30 (t, J = 6.0Hz, 1H), 4.83 (t, J = 5.4Hz, 1H), 4.39 (t, J = 6.0Hz, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H),
3.19 (qd, J = 7.2, 5.4Hz, 2H), 1.11 (t, J = 7.2Hz, 3H).
4-136 δ7.93 (s, 1H), 7.85 (s, 1H), 7.83 (s, 1H), 7.56 (d, J = 8.1Hz, 1H),
7.50 (d, J = 8.1Hz, 1H), 4.82 (bs, 1H), 4.45 (d, J = 6.0Hz, 2H),
4.2-4.3 (m, 1H), 4.10 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
3.15-3.3 (m, 2H), 1.14 (t, J = 7.2Hz, 3H).
4-137 δ8.07 (s, 3H), 7.96 (s, 1H), 7.60 (dd, J = 7.8, 1.8Hz, 1H),
7.43 (d, J = 7.8Hz, 1H), 4.97 (t, J = 6.3Hz, 1H), 4.44 (t, J = 5.8Hz, 1H),
4.36 (d, J = 6.3Hz, 2H), 4.15 (d, J = 17.4Hz, 1H), 3.71 (d, J = 17.4Hz, 1H),
3.21 (qd, J = 7.2, 5.8Hz, 2H), 1.13 (t, J = 7.2Hz, 3H).
4-138 δ7.97 (s, 1H), 7.83 (s, 1H), 7.80 (s, 1H), 7.64 (d, J = 8.1Hz, 2H),
7.39 (d, J = 8.1Hz, 2H), 4.87 (qui, J = 7.2Hz, 1H), 4.50 (d, J = 7.2Hz, 1H),
4.12 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H),
3.18 (qui, J = 7.2Hz, 2H), 1.46 (d, J = 7.2Hz, 3H), 1.08 (t, J = 7.2Hz, 3H).
4-139 δ7.76 (d, J = 5.4Hz, 2H), 7.59 (dd, J = 8.7, 1.5Hz, 2H),
7.35 (d, J = 8.7Hz, 2H), 4.85 (bs, 1H), 4.84 (qui, J = 4.8Hz, 1H),
4.46 (bs, 1H), 4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
3.15 (qd, J = 7.2, 5.4Hz, 2H), 1.42 (d, J = 4.8Hz, 3H),
1.07 (t, J = 7.2Hz, 3H).
4-140 δ8.08 (s, 2H), 7.97 (s, 1H), 7.74 (d, J = 8.4Hz, 2H),
7.58 (d, J = 8.4Hz, 2H), 6.14 (d, J = 8.4Hz, 1H), 4.85 (d, J = 8.4Hz, 1H),
4.4-4.55 (m, 1H), 4.20 (d, J = 17.4Hz, 1H), 3.76 (d, J = 17.4Hz, 1H),
3.2-3.35 (m, 2H), 1.17 (t, J = 7.2Hz, 3H).
4-141 δ8.08 (s, 2H), 7.95 (s, 1H), 7.64 (d, J = 8.4Hz, 2H),
7.40 (d, J = 8.4Hz, 2H), 5.21 (d, J = 7.5Hz, 1H), 4.95-5.05 (m, 1H),
4.70 (bs, 1H), 4.18 (d, J = 17.4Hz, 1H), 3.73 (d, J = 17.4Hz, 1H),
2.4-2.5 (m, 1H), 1.50 (d, J = 6.6Hz, 3H), 0.7-0.8 (m, 2H),
0.55-0.6 (m, 2H).
4-142 δ7.94 (s, 1H), 7.84 (s, 1H), 7.64 (d, J = 8.4Hz, 2H),
7.41 (d, J = 8.4Hz, 2H), 5.15-5.2 (m, 1H), 4.95-5.05 (m, 1H),
4.6-4.7 (m, 1H), 4.16 (d, J = 17.1Hz, 1H), 3.69 (d, J = 17.1Hz, 1H),
2.4-2.5 (m, 1H), 1.51 (d, J = 6.9Hz, 3H), 0.75-0.8 (m, 2H),
0.55-0.6 (m, 2H).
4-145 δ8.45 (s, 1H), 8.01 (s, 1H), 7.4-7.55 (m, 5H), 5.83 (t, J = 6.0Hz, 1H),
4.54 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
3.08 (s, 3H), 3.03 (s, 3H).
4-146 δ8.08 (s, 2H), 7.98 (s, 1H), 7.90 (s, 1H), 7.68 (t, J = 5.8Hz, 1H),
7.61 (dd, J = 8.1, 1.5Hz, 1H), 7.48 (d, J = 8.1Hz, 1H),
4.51 (d, J = 5.8Hz, 2H), 4.17 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H),
3.24 (s, 3H), 3.05 (s, 3H).
4-147 δ8.07 (s, 2H), 7.96 (s, 1H), 7.86 (t, J = 1.8Hz, 1H),
7.61 (d, J = 7.8Hz, 1H), 7.48 (d, J = 7.8Hz, 1H), 6.64 (t, J = 6.0Hz, 1H),
4.35-4.6 (m, 3H), 4.16 (d, J = 17.4Hz, 1H), 3.71 (d, J = 17.4Hz, 1H),
3.25-3.5 (m, 2H), 2.55-2.7 (m, 1H), 2.05-2.15 (m, 1H),
1.43 (d, J = 6.3Hz, 3H).
5-001 δ8.75 (d, J = 2.1Hz, 1H), 8.00 (dd, J = 8.1, 2.1Hz, 1H), 7.65 (s, 2H),
7.36 (d, J = 8.1Hz, 1H), 6.82 (bs, 1H), 6.20 (d, J = 5.4Hz, 2H),
4.09 (d, J = 17.1Hz, 1H), 3.71 (d, J = 17.1Hz, 1H), 1.45-1.5 (m, 1H),
0.95-1.05 (m, 2H), 0.75-0.85 (m, 2H).
5-002 δ8.52 (s, 1H), 7.61 (s, 2H), 7.51 (d, J = 1.2Hz, 2H), 6.96 (bs, 1H),
4.62 (d, J = 6.3Hz, 2H), 4.01 (d, J = 17.1Hz, 1H), 3.62 (d, J = 17.1Hz, 1H),
1.35-1.45 (m, 1H), 0.9-0.95 (m, 2H), 0.7-0.8 (m, 2H).
5-004 δ8.56 (s, 1H), 7.96 (d, J = 8.4Hz, 1H), 7.69 (dd, J = 8.4, 2.4Hz, 1H),
7.64 (s, 2H), 6.33 (d, J = 7.2Hz, 1H), 5.05-5.15 (m, 1H),
4.25 (d, J = 18.6Hz, 1H), 3.87 (d, J = 18.6Hz, 1H), 1.51 (d, J = 7.2Hz, 3H),
1.35-1.45 (m, 1H), 0.85-1.0 (m, 2H), 0.7-0.8 (m, 2H).
5-009 δ8.77 (s, 1H), 8.01 (dt, J = 8.1, 2.4Hz, 1H), 7.94 (d, J = 6.9Hz, 1H),
7.50 (d, J = 1.5Hz, 2H), 7.43 (t, J = 1.8Hz, 1H), 7.33 (d, J = 8.1Hz, 1H),
5.15-5.25 (m, 1H), 4.08 (d, J = 17.7Hz, 1H), 3.69 (d, J = 17.7Hz, 1H),
3.26 (d, J = 16.5Hz, 1H), 3.19 (d, J = 16.5Hz, 1H), 2.13 (d, J = 1.5Hz, 3H),
1.50 (d, J = 6.9Hz, 3H).
5-011 δ8.75 (d, J = 2.1Hz, 1H), 8.04 (dd, J = 8.1, 2.1Hz, 1H), 7.65 (s, 2H),
7.43 (d, J = 8.1Hz, 1H), 7.25 (bs, 1H), 6.7-6.8 (m, 2H),
4.82 (d, J = 4.8Hz, 2H), 4.09 (d, J = 17.1Hz, 1H), 3.70 (d, J = 17.1Hz, 1H).
5-013 δ8.63 (s, 1H), 7.99 (d, J = 8.1Hz, 1H), 7.75 (dd, J = 8.1, 2.1Hz, 1H),
7.65 (s, 2H), 6.65-6.75 (m, 2H), 6.55 (d, J = 7.2Hz, 1H),
5.25-5.35 (m, 1H), 4.26 (d, J = 18.6Hz, 1H), 3.88 (d, J = 18.6Hz, 1H),
1.59 (d, J = 6.9Hz, 3H).
5-014 δ7.68 (s, 1H), 7.45-7.55 (m, 4H), 7.35-7.45 (m, 2H),
5.03 (d, J = 6.0Hz, 2H), 4.04 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H),
2.64 (s, 3H).
5-015 δ7.71 (s, 1H), 7.5-7.6 (m, 2H), 7.49 (d, J = 1.5Hz, 2H),
7.42 (t, J = 1.5Hz, 1H), 6.93 (bs, 1H), 4.75-4.9 (m, 4H),
4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H).
5-016 δ7.70 (s, 1H), 7.65 (s, 2H), 7.4-7.55 (m, 2H), 6.3-6.45 (m, 2H),
4.80 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.70 (d, J = 17.4Hz, 1H),
3.00 (d, J = 5.1Hz, 3H).
5-017 δ7.45-7.75 (m, 5H), 6.85 (t, J = 6.0Hz, 1H), 6.71 (bs, 1H),
4.98 (d, J = 6.0Hz, 2H), 4.06 (d, J = 17.3Hz, 1H), 3.69 (d, J = 17.3Hz, 1H),
2.49 (bs, 1H), 0.8-0.9 (m, 2H), 0.65-0.75 (m, 2H).
5-018 δ7.64 (s, 2H), 7.61 (d, J = 8.4Hz, 2H), 7.40 (d, J = 8.4Hz, 2H),
6.41 (d, J = 7.8Hz, 1H), 6.31 (bs, 1H), 5.68 (t, J = 6.3Hz, 1H),
4.08 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 2.50 (bs, 1H),
1.61 (d, J = 6.9Hz, 3H), 0.75-1.0 (m, 2H), 0.65-0.75 (m, 2H).
5-019 δ7.6-7.7 (m, 3H), 7.4-7.55 (m, 2H), 6.35 (bs, 1H), 5.94 (bs, 1H),
4.84 (d, J = 5.7Hz, 2H), 4.07 (d, J = 17.3Hz, 1H), 3.69 (d, J = 17.3Hz, 1H),
1.7-1.8 (m, 1H), 1.54 (dt, J = 7.4, 3.9Hz, 2H), 1.19 (d, J = 6.0Hz, 3H),
0.92 (t, J = 7.4Hz, 3H).
5-020 δ8.52 (s, 1H), 7.94 (d, J = 8.4Hz, 1H), 7.64 (dd, J = 7.8, 2.4Hz, 1H),
7.64 (s, 2H), 5.44 (dd, J = 7.2, 3.0Hz, 1H), 5.35 (t, J = 4.8Hz, 1H),
4.9-5.0 (m, 1H), 4.23 (d, J = 18.3Hz, 1H), 3.85 (d, J = 18.3Hz, 1H),
3.65-3.85 (m, 2H), 1.43 (d, J = 7.2Hz, 3H).
5-021 δ7.55-7.65 (m, 3H), 7.2-7.4 (m, 7H), 6.63 (bs, 1H), 6.47 (bs, 1H),
4.76 (d, J = 6.0Hz, 2H), 4.55 (d, J = 4.8Hz, 2H), 4.02 (d, J = 17.3Hz, 1H),
3.65 (d, J = 17.3Hz, 1H).
5-022 δ10.18 (bs, 1H), 8.26 (bs, 1H), 7.5-7.75 (m, 5H), 4.98 (d, J = 5.7Hz, 2H),
4.21 (q, J = 7.1Hz, 2H), 4.05 (d, J = 17.3Hz, 1H), 3.67 (d, J = 17.3Hz, 1H),
1.31 (t, J = 7.1Hz, 3H).
6-002 δ7.7-7.75 (m, 1H), 7.50 (d, J = 1.5Hz, 2H), 7.46 (d, J = 8.4Hz, 2H),
7.43 (t, J = 1.8Hz, 1H), 7.21 (d, J = 8.4Hz, 2H), 6.75-6.9 (m, 2H),
5.20 (d, J = 6.9Hz, 1H), 4.5-4.6 (m, 1H), 4.00 (d, J = 17.1Hz, 1H),
3.65 (d, J = 17.1Hz, 1H), 1.45 (d, J = 6.9Hz, 3H).
6-003 δ7.7-7.75 (m, 1H), 7.65 (s, 2H), 7.50 (d, J = 8.7Hz, 2H),
7.20 (d, J = 8.7Hz, 2H), 6.75-6.9 (m, 2H), 5.30 (d, J = 7.5Hz, 1H),
4.5-4.6 (m, 1H), 4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H),
1.50 (d, J = 6.9Hz, 3H).
7-001 δ7.61 (d, J = 8.1Hz, 2H), 7.4-7.55 (m, 4H), 7.3-7.4 (m, 3H),
7.1-7.3 (m, 3H), 4.7-4.8 (m, 2H), 3.95-4.15 (m, 2H),
3.68 (d, J = 17.4Hz, 1H), 3.15-3.35 (m, 1H), 2.75-2.95 (m, 1H).
7-003 δ7.75 and 7.64 (s, 1H), 7.4-7.6 (m, 4H), 7.25-7.35 (m, 1H),
4.77 and 4.72 (s, 2H), 4.06 and 4.04 (d, J = 17.4Hz, 1H),
3.68 and 3.65 (d, J = 17.4Hz, 1H), 3.45-3.55 (m, 2H), 0.6-1.5 (m, 8H).
7-004 δ7.67 (d, J = 1.5Hz, 1H), 7.54 (dd, J = 8.1, 1.5Hz, 1H), 7.49 (s, 2H),
7.43 (t, J = 1.5Hz, 1H), 7.39 (d, J = 8.1Hz, 1H), 4.98 (s, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.75 (s, 3H), 3.66 (d, J = 17.4Hz, 1H),
1.55-1.65 (m, 1H), 1.0-1.1 (m, 2H), 0.85-0.95 (m, 2H).
7-005 δ7.67 (d, J = 1.5Hz, 1H), 7.54 (dd, J = 8.1, 1.5Hz, 1H), 7.50 (s, 2H),
7.35-7.45 (m, 2H), 4.98 (s, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.97 (q, J = 6.9Hz, 2H), 3.66 (d, J = 17.4Hz, 1H), 1.55-1.65 (m, 1H),
1.23 (t, J = 6.9Hz, 3H), 1.0-1.1 (m, 2H), 0.8-0.95 (m, 2H).
7-006 δ7.76 and 7.67 (d, J = 1.5Hz, 1H), 7.58 and 7.53 (dd, J = 8.1, 1.5Hz, 1H),
7.49 (s, 2H), 7.43 (t, J = 1.5Hz, 1H), 7.31 and 7.15 (d, J = 8.1Hz, 1H),
4.83 and 4.77 (s, 2H), 3.8-4.15 (m, 3H),
3.68 and 3.66 (d, J = 17.4Hz, 1H), 2.25 and 2.13 (s, 3H).
7-007 δ7.76 and 7.67 (s, 1H), 7.45-7.55 (m, 3H), 7.43 (s, 1H),
7.29 and 7.11 (d, J = 8.1Hz, 1H), 4.83 and 4.76 (s, 2H),
3.85-4.15 (m, 3H), 3.67 and 3.66 (d, J = 17.4Hz, 1H),
2.47 and 2.33 (q, J = 7.2Hz, 2H), 1.1-1.25 (m, 3H).
7-008 δ7.63 (s, 1H), 7.45-7.6 (m, 3H), 7.49 (t, J = 1.5Hz, 1H),
7.17 (d, J = 8.1Hz, 1H), 4.72 (s, 2H), 4.04 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 2.75-2.85 (m, 1H), 2.25-2.4 (m, 1H),
1.0-1.1 (m, 2H), 0.75-0.95 (m, 6H).
7-009 δ7.74 and 7.63 (d, J = 1.5Hz, 1H), 7.45-7.6 (m, 3H), 7.42 (s, 1H),
7.35 and 7.24 (d, J = 8.1Hz, 1H), 4.89 and 4.82 (s, 2H),
4.06 and 4.04 (d, J = 17.4Hz, 1H), 3.68 and 3.65 (d, J = 17.4Hz, 1H),
3.37 and 3.35 (d, J = 6.0Hz, 2H), 1.85-1.95 and 1.4-1.5 (m, 1H),
0.95-1.1 (m, 3H), 0.8-0.9 and 0.75-0.85 (m, 2H),
0.5-0.6 and 0.4-0.5 (m, 2H), 0.15-0.25 (m, 2H).
7-010 δ7.76 and 7.67 (s, 1H), 7.4-7.6 (m, 4H), 7.2-7.35 (m, 1H),
4.94 and 4.84 (s, 2H), 4.0-4.2 (m, 3H),
3.68 and 3.66 (d, J = 17.4Hz, 1H), 1.65-1.85 (m, 1H), 1.0-1.1 (m, 2H),
0.85-0.95 and 0.75-0.85 (m, 2H).
7-011 δ7.73 and 7.64 (d, J = 1.5Hz, 1H), 7.45-7.6 (m, 3H),
7.43 (t, J = 1.5Hz, 1H), 7.2-7.35 (m, 1H), 4.90 and 4.76 (s, 2H),
4.07 and 4.04 (d, J = 17.4Hz, 1H), 3.75 and 3.60 (m, 3H),
3.5-3.6 (m, 2H), 3.33 and 3.29 (s, 3H), 1.85-2.0 and 1.35-1.5 (m, 1H),
0.95-1.1 (m, 2H), 0.8-0.9 and 0.65-0.8 (m, 2H).
7-012 δ7.75 and 7.65 (d, J = 1.5Hz, 1H), 7.4-7.6 (m, 4H), 7.2-7.3 (m, 1H),
4.80 and 4.74 (s, 2H), 4.07 and 4.05 (d, J = 17.4Hz, 1H),
3.69 and 3.66 (d, J = 17.4Hz, 1H), 3.17 and 3.03 (s, 3H),
1.8-1.9 and 1.45-1.55 (m, 1H), 1.0-1.1 (m, 2H),
0.8-0.9 and 0.65-0.75 (m, 2H).
7-013 δ7.74 and 7.65 (d, J = 1.5Hz, 1H), 7.5-7.6 (m, 3H), 7.25-7.45 (m, 2H),
4.75-4.95 (m, 4H), 4.07 and 4.04 (d, J = 17.4Hz, 1H),
3.68 and 3.66 (d, J = 17.4Hz, 1H), 3.35 (s, 3H),
1.9-2.0 and 1.4-1.5 (m, 1H), 1.0-1.1 (m, 2H),
0.85-0.95 and 0.7-0.8 (m, 2H).
7-015 δ7.73 (s, 1H), 7.57 (d, J = 8.1Hz, 1H), 7.50 (d, J = 1.5Hz, 2H),
7.43 (t, J = 1.5Hz, 1H), 7.28 (d, J = 8.1Hz, 1H), 7.14 (bs, 1H),
4.91 (s, 2H), 3.95-4.25 (m, 3H), 3.8-3.9 (m, 2H),
3.67 (d, J = 17.4Hz, 1H), 1.5-1.65 (m, 1H), 1.0-1.1 (m, 2H),
0.8-0.9 (m, 2H).
7-016 δ8.39 (d, J = 2.7Hz, 1H), 7.66 (dd, J = 8.4, 2.7Hz, 1H),
7.61 (d, J = 1.5Hz, 1H), 7.4-7.55 (m, 6H), 5.27 (s, 2H),
4.03 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H), 1.55-1.6 (m, 1H),
1.1-1.2 (m, 2H), 0.75-0.85 (m, 2H).
7-017 δ7.74 and 7.66 (d, J = 1.5Hz, 1H), 7.4-7.6 (m, 4H),
7.20 and 7.16 (d, J = 8.1Hz, 1H), 4.75 and 4.60 (s, 2H),
4.06 and 4.05 (d, J = 17.4Hz, 1H), 3.69 and 3.68 (d, J = 17.4Hz, 1H),
3.00 and 2.98 (s, 3H), 2.37 and 2.20 (d, J = 6.6Hz, 2H), 1.0-1.2 (m, 1H),
0.5-0.65 (m, 2H), 0.15-0.25 and 0.05-0.15 (m, 2H).
7-018 δ7.68 (d, J = 1.5Hz, 1H), 7.55 (dd, J = 8.1, 1.5Hz, 1H), 7.4-7.5 (m, 4H),
6.58 (bs, 1H), 4.70 (s, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.85-4.0 (m, 4H),
3.78 (s, 3H), 3.67 (d, J = 17.4Hz, 1H).
7-019 δ7.65 (s, 2H), 7.60 (d, J = 8.1Hz, 2H), 7.30 (d, J = 8.1Hz, 2H),
5.6-5.7 (m, 1H), 4.05 (d, J = 17.1Hz, 1H), 3.65 (d, J = 17.1Hz, 1H),
2.5-2.65 (m, 4H), 1.75 (d, J = 7.2Hz, 3H), 1.10 (t, J = 7.5Hz, 6H).
7-020 δ7.75 (s, 1H), 7.1-7.7 (m, 4H), 4.73 and 4.62 (s, 2H),
4.08 and 4.06 (d, J = 17.4Hz, 1H), 3.69 and 3.68 (d, J = 17.4Hz, 1H),
3.00 and 2.99 (s, 3H), 2.40 and 2.34 (t, J = 7.5Hz, 2H),
1.71 (sep, J = 7.5Hz, 2H), 1.00 and 0.91 (t, J = 7.5Hz, 3H).
7-021 δ7.74 (s, 1H), 7.5-7.65 (m, 3H), 7.27 (s, 1H), 4.81 and 4.74 (s, 2H),
4.09 and 4.06 (d, J = 17.4Hz, 1H), 3.70 and 3.67 (d, J = 17.4Hz, 1H),
3.49 and 3.39 (q, J = 7.2Hz, 1H), 3.17 and 3.03 (s, 3H),
0.95-1.1 (m, 4H).
7-023 δ7.70 (s, 2H), 7.67 (d, J = 8.1Hz, 2H), 7.37 (d, J = 8.1Hz, 2H),
6.02 and 5.47 (bs, 1H), 4.09 (d, J = 17.7Hz, 1H), 3.68 (d, J = 17.7Hz, 1H),
3.05-3.45 (m, 2H), 1.65-1.8 (m, 1H), 1.54 (d, J = 6.9Hz, 3H),
0.95-1.15 (m, 5H), 0.65-0.95 (m, 2H).
7-024 δ7.74 and 7.63 (s, 1H), 7.63 (s, 2H), 7.45-7.55 (m, 1H),
7.2-7.4 (m, 1H), 4.90 and 4.82 (s, 2H),
4.07 and 4.04 (d, J = 17.4Hz, 1H), 3.67 and 3.65 (d, J = 17.4Hz, 1H),
3.3-3.5 (m, 2H), 1.75-1.9 and 1.35-1.5 (m, 1H), 0.95-1.15 (m, 2H),
0.85-1.0 (m, 1H), 0.75-0.9 (m, 1H), 0.6-0.75 (m, 1H), 0.4-0.6 (m, 2H),
0.15-0.3 (m, 2H).
7-025 δ7.65 (s, 2H), 7.62 (d, J = 8.1Hz, 2H), 7.37 (d, J = 8.1Hz, 2H),
5.94 and 5.45 (bs, 1H), 4.08 (d, J = 17.1Hz, 1H), 3.68 (d, J = 17.1Hz, 1H),
3.25 (dd, J = 15.6, 6.0Hz, 1H), 2.97 (dd, J = 15.6, 6.0Hz, 1H),
1.45-2.95 (m, 4H), 0.6-1.15 (m, 5H), 0.35-0.6 (m, 2H),
0.05-0.2 (m, 2H).
7-026 δ7.73 and 7.63 (s, 1H), 7.63 (s, 2H), 7.45-7.6 (m, 1H),
7.25-7.4 (m, 1H), 4.87 and 4.78 (s, 2H), 4.86 and 4.78 (s, 2H),
4.08 and 4.05 (d, J = 17.4Hz, 1H), 3.68 and 3.66 (d, J = 17.4Hz, 1H),
3.35 (s, 3H), 1.4-1.55 and 1.9-2.0 (m, 1H), 1.0-1.15 (m, 2H),
0.8-0.95 and 0.65-0.8 (m, 2H).
7-027 δ7.74 and 7.65 (d, J = 1.5Hz, 1H), 7.4-7.6 (m, 4H), 7.25-7.35 (m, 1H),
4.85 and 4.77 (s, 2H), 4.06 and 4.04 (d, J = 17.4Hz, 1H),
3.55-3.75 (m, 3H), 2.65-2.75 (m, 2H), 2.14 and 2.12 (s, 3H),
1.75-1.85 and 1.4-1.55 (m, 1H), 1.0-1.15 (m, 2H),
0.8-0.9 and 0.65-0.8 (m, 2H).
7-029 δ7.67 and 7.61 (d, J = 8.1Hz, 2H), 7.64 (bs, 2H),
7.41 and 7.36 (d, J = 8.1Hz, 2H), 6.05-6.1 and 5.5-5.6 (m, 1H),
4.0-4.15 (m, 2H), 3.5-3.85 (m, 2H), 3.67 (s, 3H), 1.8-1.85 (m, 1H),
1.69 and 1.48 (d, J = 6.9Hz, 3H), 1.05-1.1 (m, 2H), 0.75-0.85 (m, 2H).
7-030 δ7.74 and 7.63 (s, 1H), 7.63 (s, 2H), 7.45-7.6 (m, 1H),
7.25-7.4 (m, 1H), 4.94 and 4.80 (s, 2H), 4.30 and 4.23 (s, 2H),
4.09 and 4.06 (d, J = 17.4Hz, 1H), 3.70 and 3.68 (d, J = 17.4Hz, 1H),
2.32 and 2.20 (s, 1H), 1.4-1.6 and 1.85-2.0 (m, 1H), 1.0-1.15 (m, 2H),
0.8-0.95 and 0.65-0.8 (m, 2H).
7-031 δ7.73 (d, J = 1.8Hz, 1H), 7.63 (s, 2H), 7.59 (dd, J = 7.8, 1.8Hz, 1H),
7.44 (d, J = 7.8Hz, 1H), 4.87 (s, 2H), 4.06 (d, J = 17.4Hz, 1H),
3.67 (d, J = 17.4Hz, 1H), 2.25-2.35 (m, 1H), 1.15-1.25 (m, 2H),
1.05-1.15 (m, 2H).
7-032 δ7.82 (s, 1H), 7.56 (d, J = 8.1Hz, 1H), 7.49 (s, 2H), 7.42 (s, 1H),
7.05 (d, J = 8.1Hz, 1H), 4.95 (s, 2H), 4.04 (d, J = 17.1Hz, 1H),
3.65 (d, J = 17.1Hz, 1H), 2.85-2.95 (m, 1H), 1.44 (s, 9H),
1.1-1.2 (m, 2H), 0.95-1.05 (m, 2H).
7-035 δ7.54 (d, J = 8.4Hz, 2H), 7.50 (d, J = 1.5Hz, 2H), 7.42 (t, J = 1.8Hz, 1H),
7.31 (d, J = 8.4Hz, 2H), 6.75-6.85 (m, 1H), 6.5-6.6 (m, 1H),
5.95-6.05 (m, 1H), 4.05 (d, J = 17.1Hz, 1H), 3.65 (d, J = 17.1Hz, 1H),
1.45-1.55 (m, 3H), 1.0-1.05 (m, 2H), 1.05-1.1 (m, 1H),
0.6-0.65 (m, 2H).
7-036 δ7.5-7.75 (m, 4H), 7.1-7.3 (m, 1H), 4.74 and 4.68 (s, 2H),
4.0-4.15 (m, 2H), 3.85-3.95 (m, 3H), 3.70 and 3.68 (d, J = 17.4Hz, 1H),
3.34 and 3.09 (qui, J = 7.8Hz, 1H), 3.04 and 3.02 (s, 3H),
2.1-2.3 (m, 2H).
7-037 δ7.67 (s, 1H), 7.53 (d, J = 8.4Hz, 1H), 7.49 (s, 2H), 7.42 (s, 1H),
7.33 (d, J = 8.4Hz, 1H), 4.61 (s, 2H), 4.06 (d, J = 17.1Hz, 1H),
3.67 (d, J = 17.1Hz, 1H), 3.33 (t, J = 6.9Hz, 2H), 2.46 (t, J = 8.4Hz, 2H),
2.0-2.15 (m, 2H).
7-038 δ7.66 (s, 1H), 7.53 (d, J = 8.4Hz, 1H), 7.49 (s, 2H), 7.42 (s, 1H),
7.24 (d, J = 8.4Hz, 1H), 4.74 (s, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 3.2-3.35 (m, 2H), 2.45-2.6 (m, 2H),
1.75-2.0 (m, 4H).
7-039 δ7.66 (s, 1H), 7.54 (d, J = 8.1Hz, 1H), 7.50 (s, 2H), 7.43 (s, 1H),
7.36 (d, J = 8.1Hz, 1H), 4.74 (s, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 3.0-3.4 (m, 2H), 2.55-2.7 (m, 2H),
1.65-1.75 (m, 4H), 1.5-1.7 (m, 2H).
7-041 δ7.15-7.7 (m, 7H), 6.7-6.8 (m, 2H), 6.15-6.25 and 4.8-4.9 (m, 1H),
4.05-4.15 (m, 1H), 3.65-3.75 (m, 1H), 2.80 and 2.50 (s, 3H),
1.6-1.65 (m, 3H).
7-042 δ7.5-7.75 (m, 4H), 7.43 and 7.32 (d, J = 8.1Hz, 1H),
6.77 and 6.67 (t, J = 7.2Hz, 2H), 4.91 and 4.54 (s, 2H),
4.07 and 4.06 (d, J = 17.4Hz, 1H), 3.69 and 3.67 (d, J = 17.4Hz, 1H),
3.54 and 3.22 (q, J = 7.2Hz, 2H), 1.11 and 0.88 (t, J = 7.2Hz, 3H).
7-044 δ7.71 (s, 1H), 7.56 (d, J = 8.1Hz, 1H), 7.50 (s, 2H), 7.4-7.5 (m, 2H),
4.60 (s, 2H), 4.35 (dd, J = 7.8, 6.9Hz, 2H), 4.06 (d, J = 17.4Hz, 1H),
3.67 (d, J = 17.4Hz, 1H), 3.53 (dd, J = 7.8, 6.9Hz, 2H).
7-045 δ7.6-7.75 (m, 3H), 7.5-7.65 (m, 1H), 7.15-7.25 (m, 1H),
4.96 (d, J = 2.1Hz, 2H), 4.79 (s, 2H), 4.0-4.2 (m, 3H),
3.67 (d, J = 17.3Hz, 1H).
7-046 δ7.70 (d, J = 1.8Hz, 1H), 7.53 (dd, J = 8.4, 1.8Hz, 1H), 7.49 (s, 2H),
7.42 (t, J = 1.8Hz, 1H), 7.36 (d, J = 8.4Hz, 1H), 4.59 (s, 2H),
4.5-4.6 (m, 1H), 4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H),
3.49 (t, J = 7.2Hz, 2H), 3.2-3.35 (m, 2H), 2.67 (t, J = 7.2Hz, 2H),
2.15 (s, 3H), 1.10 (t, J = 7.2Hz, 3H).
7-047 δ7.66 (d, J = 1.8Hz, 1H), 7.63 (s, 2H), 7.5-7.6 (m, 1H), 7.30 (s, 1H),
6.02 (bs, 1H), 4.83 (s, 2H), 4.07 (s, 2H), 4.05 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H).
7-048 δ8.07 (s, 2H), 7.97 (s, 1H), 7.77 and 7.68 (d, J = 1.5Hz, 1H),
7.5-7.6 (m, 1H), 7.32 and 7.18 (d, J = 8.4Hz, 1H), 4.75 and 4.61 (s, 2H),
4.19 and 4.17 (d, J = 17.4Hz, 1H), 3.74 and 3.73 (d, J = 17.4Hz, 1H),
3.00 and 2.99 (s, 3H), 2.38 and 2.22 (d, J = 6.9Hz, 2H), 1.0-1.2 (m, 1H),
0.4-0.55 (m, 2H), 0.15-0.25 and 0.05-0.15 (m, 2H).
7-049 δ8.07 (s, 2H), 7.97 (s, 1H), 7.76 and 7.67 (d, J = 1.8Hz, 1H),
7.5-7.6 (m, 1H), 7.15-7.35 (m, 1H), 4.72 and 4.57 (s, 2H),
4.19 and 4.17 (d, J = 17.4Hz, 1H), 3.75 and 3.73 (d, J = 17.4Hz, 1H),
3.45 and 3.33 (q, J = 7.2Hz, 2H), 2.38 and 2.16 (d, J = 6.9Hz, 2H),
1.0-1.3 (m, 4H), 0.45-0.65 (m, 2H), 0.15-0.25 and 0.0-0.1 (m, 2H).
7-050 δ8.08 (s, 2H), 7.97 (s, 1H), 7.77 and 7.68 (d, J = 1.5Hz, 1H),
7.45-7.55 (m, 1H), 7.3-7.4 and 7.15-7.3 (m, 1H), 4.74 and 4.59 (s, 2H),
4.20 and 4.18 (d, J = 17.4Hz, 1H), 3.75 and 3.74 (d, J = 17.4Hz, 1H),
3.56 and 3.21 (t, J = 7.8Hz, 2H), 2.38 and 2.17 (d, J = 6.9Hz, 2H),
1.61 and 1.59 (qui, J = 7.8Hz, 2H), 1.0-1.2 (m, 1H),
0.91 (t, J = 7.8Hz, 3H), 0.45-0.7 (m, 2H),
0.15-0.25 and 0.0-0.15 (m, 2H).
7-051 δ8.07 (s, 2H), 7.97 (s, 1H), 7.76 and 7.66 (d, J = 1.5Hz, 1H),
7.5-7.6 (m, 1H), 7.2-7.3 (m, 1H), 4.84 and 4.70 (s, 2H),
4.19 and 4.17 (d, J = 17.4Hz, 1H), 3.77 and 3.73 (d, J = 17.4Hz, 1H),
3.34 and 3.18 (q, J = 6.9Hz, 2H), 2.43 and 2.19 (d, J = 6.9Hz, 2H),
0.85-1.2 (m, 2H), 0.45-0.7 (m, 4H), 0.05-0.3 (m, 4H).
7-052 δ8.08 (s, 2H), 7.97 (s, 1H), 7.76 and 7.68 (d, J = 1.5Hz, 1H),
7.5-7.6 (m, 1H), 7.3-7.4 and 7.2-7.3 (m, 1H), 4.82 and 4.75 (s, 2H),
4.20 and 4.18 (d, J = 17.4Hz, 1H), 4.29 and 4.03 (d, J = 2.4Hz, 2H),
3.75 and 3.74 (d, J = 17.4Hz, 1H), 2.46 and 2.28 (q, J = 6.9Hz, 2H),
2.2-2.25 (m, 1H), 1.0-1.2 (m, 1H), 0.15-0.3 (m, 2H), 0.0-0.15 (m, 2H).
7-053 δ8.08 (s, 2H), 7.97 (s, 1H), 7.90 (s, 1H), 7.77 (d, J = 1.5Hz, 1H),
7.6-7.7 (m, 1H), 7.4-7.5 (m, 1H), 7.22 (s, 1H), 7.08 (t, J = 0.9Hz, 1H),
4.77 (s, 2H), 4.20 (d, J = 17.4Hz, 1H), 3.76 (d, J = 17.4Hz, 1H),
3.09 (s, 3H).
7-060 δ8.08 (s, 2H), 7.98 (s, 1H), 7.76 (d, J = 1.5Hz, 1H), 7.5-7.65 (m, 1H),
7.25-7.4 (m, 1H), 6.32 and 6.05 (bs, 1H), 5.96 and 5.70 (bs, 1H),
4.78 and 4.75 (s, 2H), 4.19 and 4.17 (d, J = 17.4Hz, 1H),
3.98 and 3.96 (s, 2H), 3.75 (d, J = 17.4Hz, 1H), 2.18 and 2.16 (s, 3H).
7-061 δ8.07 (s, 2H), 7.97 (s, 1H), 7.75 and 7.69 (d, J = 1.5Hz, 1H),
7.5-7.65 (m, 1H), 7.2-7.4 (m, 1H), 6.33 and 5.88 (bs, 1H),
4.76 and 4.74 (s, 2H), 4.18 and 4.16 (d, J = 17.4Hz, 1H),
3.95 and 3.93 (s, 2H), 3.73 (d, J = 17.4Hz, 1H),
2.83 and 2.78 (d, J = 5.1Hz, 3H), 2.17 and 2.15 (s, 3H).
7-062 δ8.08 (s, 2H), 7.97 (s, 1H), 7.77 and 7.67 (d, J = 1.8Hz, 1H),
7.5-7.6 (m, 1H), 7.2-7.35 (m, 1H), 4.71 and 4.59 (s, 2H),
4.19 and 4.17 (d, J = 17.4Hz, 1H), 3.75 and 3.73 (d, J = 17.4Hz, 1H),
3.45 and 3.34 (q, J = 7.2Hz, 2H), 2.47 and 2.23 (q, J = 7.2Hz, 2H),
1.05-1.25 (m, 6H).
7-063 δ7.93 (s, 1H), 7.83 (s, 1H), 7.75 and 7.65 (s, 1H),
7.4-7.6 and 7.15-7.35 (m, 2H), 4.72 and 4.59 (s, 2H),
4.11 and 4.10 (d, J = 17.4Hz, 1H), 3.69 and 3.67 (d, J = 17.4Hz, 1H),
3.45 and 3.33 (q, J = 6.9Hz, 2H), 2.46 and 2.40 (q, J = 7.8Hz, 2H),
1.05-1.25 (m, 6H).
7-065 δ8.08 (s, 2H), 7.97 (s, 1H), 7.77 and 7.66 (d, J = 1.8Hz, 1H),
7.5-7.6 (m, 1H), 7.15-7.3 (m, 1H), 4.72 and 4.60 (s, 2H),
4.19 and 4.17 (d, J = 17.4Hz, 1H), 3.75 and 3.73 (d, J = 17.4Hz, 1H),
3.35 and 3.22 (t, J = 7.5Hz, 2H), 2.47 and 2.23 (q, J = 7.5Hz, 2H),
1.5-1.7 (m, 2H), 1.21 and 1.11 (t, J = 7.5Hz, 3H),
0.91 and 0.90 (t, J = 7.5Hz, 3H).
7-066 δ8.07 (s, 2H), 7.97 (s, 1H), 7.80 (s, 1H), 7.55-7.65 (m, 1H),
7.2-7.3 (m, 1H), 4.77 (s, 2H), 4.32 (s, 2H), 4.19 (d, J = 17.4Hz, 1H),
3.75 (d, J = 17.4Hz, 1H), 2.41 (q, J = 7.2Hz, 2H),
1.26 and 1.18 (t, J = 7.2Hz, 3H).
7-067 δ7.93 (s, 1H), 7.82 (s, 1H), 7.78 (s, 1H), 7.5-7.6 (m, 1H),
7.15-7.25 (m, 1H), 4.77 (s, 2H), 4.32 (s, 2H), 4.12 (d, J = 17.4Hz, 1H),
3.70 (d, J = 17.4Hz, 1H), 2.35-2.45 (m, 2H),
1.18 and 1.16 (t, J = 7.2Hz, 3H).
7-068 δ8.08 (s, 2H), 7.97 (s, 1H), 7.75 and 7.69 (d, J = 1.5Hz, 1H),
7.5-7.65 (m, 1H), 7.2-7.4 (m, 1H), 6.25 and 5.84 (bs, 1H),
5.72 and 5.52 (bs, 1H), 4.80 and 4.75 (s, 2H), 4.18 (d, J = 17.4Hz, 1H),
4.00 and 3.96 (s, 2H), 3.73 (d, J = 17.4Hz, 1H), 2.38 (q, J = 7.5Hz, 2H),
1.15 (t, J = 7.5Hz, 3H).
7-069 δ8.07 (s, 2H), 7.97 (s, 1H), 7.68 and 7.60 (d, J = 1.5Hz, 1H),
7.5-7.65 (m, 1H), 7.2-7.4 (m, 1H), 6.42 and 6.16 (bs, 1H),
4.75 (s, 2H), 4.19 (d, J = 17.4Hz, 1H), 3.97 (s, 2H),
3.75 (d, J = 17.4Hz, 1H), 2.78 (d, J = 5.1Hz, 3H), 2.37 (q, J = 7.5Hz, 2H),
1.14 (t, J = 7.5Hz, 3H).
7-070 δ8.07 (s, 2H), 7.97 (s, 1H), 7.77 and 7.66 (d, J = 1.5Hz, 1H),
7.5-7.6 (m, 1H), 7.15-7.35 (m, 1H), 5.65-5.85 (m, 1H),
5.05-5.3 (m, 2H), 4.71 and 4.56 (s, 2H),
4.19 and 4.17 (d, J = 17.4Hz, 1H), 4.04 and 3.90 (d, J = 5.7Hz, 2H),
3.75 and 3.73 (d, J = 17.4Hz, 1H), 2.44 and 2.27 (q, J = 7.5Hz, 2H),
1.20 and 1.13 (t, J = 7.5Hz, 3H).
7-071 δ7.94 (s, 1H), 7.84 (s, 1H), 7.76 and 7.65 (s, 1H), 7.5-7.6 (m, 1H),
7.15-7.35 (m, 1H), 5.7-5.85 (m, 1H), 5.05-5.3 (m, 2H),
4.72 and 4.58 (s, 2H), 4.11 (d, J = 17.4Hz, 1H),
4.04 and 3.90 (d, J = 6.0Hz, 2H), 3.69 (d, J = 17.4Hz, 1H),
2.45 and 2.28 (q, J = 7.5Hz, 2H), 1.20 and 1.14 (t, J = 7.5Hz, 3H).
7-072 δ8.08 (s, 2H), 7.97 (s, 1H), 7.77 and 7.68 (s, 1H), 7.5-7.6 (m, 1H),
7.35 and 7.26 (d, J = 7.8Hz, 1H), 4.81 and 4.77 (s, 2H),
4.20 and 4.18 (d, J = 17.4Hz, 1H), 4.29 and 4.04 (d, J = 2.4Hz, 2H),
3.75 and 3.74 (d, J = 17.4Hz, 1H), 2.55 and 2.39 (q, J = 7.5Hz, 2H),
2.29 and 2.21 (t, J = 2.4Hz, 1H), 1.22 and 1.16 (t, J = 7.5Hz, 3H).
7-073 δ8.07 (s, 2H), 7.97 (s, 1H), 7.77 and 7.66 (d, J = 1.8Hz, 1H),
7.5-7.6 (m, 1H), 7.2-7.35 (m, 1H), 4.71 and 4.59 (s, 2H),
4.20 and 4.17 (d, J = 17.4Hz, 1H), 3.75 and 3.73 (d, J = 17.4Hz, 1H),
3.44 and 3.35 (q, J = 7.2Hz, 2H), 2.42 and 2.18 (t, J = 7.5Hz, 2H),
1.6-1.85 (m, 2H), 1.19 and 1.14 (t, J = 6.9Hz, 3H),
1.00 and 0.90 (t, J = 7.2Hz, 3H).
7-074 δ7.94 (s, 1H), 7.83 (s, 1H), 7.76 and 7.66 (s, 1H),
7.45-7.6 and 7.15-7.35 (m, 2H), 4.72 and 4.59 (s, 2H),
4.11 and 4.10 (d, J = 17.4Hz, 1H), 3.69 and 3.67 (d, J = 17.4Hz, 1H),
3.44 and 3.34 (q, J = 7.2Hz, 2H), 2.41 and 2.35 (t, J = 7.5Hz, 2H),
1.6-1.8 (m, 2H), 1.18 and 1.14 (t, J = 7.2Hz, 3H),
1.00 and 0.98 (t, J = 7.5Hz, 3H).
7-075 δ8.08 (s, 2H), 7.97 (s, 1H), 7.77 and 7.67 (d, J = 1.8Hz, 1H),
7.5-7.6 (m, 1H), 7.15-7.3 (m, 1H), 4.72 and 4.60 (s, 2H),
4.20 and 4.17 (d, J = 17.4Hz, 1H), 3.76 and 3.74 (d, J = 17.4Hz, 1H),
3.34 and 3.22 (t, J = 7.5Hz, 2H), 2.41 and 2.18 (t, J = 7.2Hz, 2H),
1.5-1.8 (m, 4H), 0.7-1.1 (m, 6H).
7-076 δ8.07 (s, 2H), 7.97 (s, 1H), 7.80 (s, 1H), 7.6-7.7 (m, 1H),
7.2-7.3 (m, 1H), 4.77 (s, 2H), 4.31 (s, 2H), 4.19 (d, J = 17.4Hz, 1H),
3.75 (d, J = 17.4Hz, 1H), 2.35 (t, J = 7.5Hz, 2H), 1.71 (sxt, J = 7.5Hz, 2H),
0.95 (t, J = 7.5Hz, 3H).
7-077 δ7.93 (s, 1H), 7.82 (s, 1H), 7.78 (s, 1H), 7.55-7.65 (m, 1H),
7.2-7.3 (m, 1H), 4.77 (s, 2H), 4.31 (s, 2H), 4.11 (d, J = 17.4Hz, 1H),
3.72 (d, J = 17.4Hz, 1H), 2.35 (t, J = 7.2Hz, 2H), 1.6-1.85 (m, 2H),
0.94 (t, J = 7.2Hz, 3H).
7-078 δ8.08 (s, 2H), 7.97 (s, 1H), 7.76 and 7.69 (d, J = 1.5Hz, 1H),
7.5-7.65 (m, 1H), 7.2-7.4 (m, 1H), 6.36 and 6.19 (bs, 1H),
6.05 and 5.82 (bs, 1H), 4.79 and 4.76 (s, 2H), 4.19 (d, J = 17.4Hz, 1H),
3.99 (s, 2H), 3.74 (d, J = 17.4Hz, 1H), 2.32 (t, J = 7.5Hz, 2H),
2.55-2.75 (m, 2H), 0.85-1.05 (m, 3H).
7-079 δ8.08 (s, 2H), 7.97 (s, 1H), 7.75 and 7.69 (d, J = 1.5Hz, 1H),
7.5-7.65 (m, 1H), 7.2-7.4 (m, 1H), 6.39 and 6.04 (bs, 1H),
4.76 (s, 2H), 4.19 (d, J = 17.4Hz, 1H), 3.96 (s, 2H),
3.74 (d, J = 17.4Hz, 1H), 2.78 (d, J = 5.1Hz, 3H), 2.31 (t, J = 7.5Hz, 2H),
1.68 (sxt, J = 7.5Hz, 2H), 0.92 (t, J = 7.5Hz, 3H).
7-080 δ7.94 (s, 1H), 7.83 (s, 1H), 7.75 and 7.65 (s, 1H), 7.5-7.6 (m, 1H),
7.15-7.35 (m, 1H), 5.7-5.85 (m, 1H), 5.05-5.3 (m, 2H),
4.71 and 4.58 (s, 2H), 4.13 and 4.11 (d, J = 17.4Hz, 1H),
4.02 and 3.90 (d, J = 6.0Hz, 2H), 3.70 and 3.68 (d, J = 17.4Hz, 1H),
2.39 and 2.22 (t, J = 7.5Hz, 2H), 1.6-1.8 (m, 2H),
0.98 and 0.91 (t, J = 7.5Hz, 3H).
7-081 δ8.08 (s, 2H), 7.97 (s, 1H), 7.78 and 7.68 (d, J = 1.5Hz, 1H),
7.5-7.6 (m, 1H), 7.50 and 7.25 (d, J = 7.8Hz, 1H), 4.81 and 4.77 (s, 2H),
4.20 and 4.17 (d, J = 17.4Hz, 1H), 4.28 and 4.04 (d, J = 2.4Hz, 2H),
3.75 and 3.73 (d, J = 17.4Hz, 1H), 2.49 and 2.23 (t, J = 7.2Hz, 2H),
2.29 and 2.21 (t, J = 2.4Hz, 1H), 1.6-1.8 (m, 2H),
1.01 and 0.91 (t, J = 7.2Hz, 3H).
7-083 δ7.93 (s, 1H), 7.82 (s, 1H), 7.76 and 7.66 (s, 1H), 7.55-7.6 (m, 1H),
7.2-7.3 (m, 1H), 4.80 and 4.74 (s, 2H),
4.16 and 4.10 (d, J = 17.4Hz, 1H), 3.69 and 3.67 (d, J = 17.4Hz, 1H),
3.17 and 3.03 (s, 3H), 1.45-1.65 (m, 1H), 1.0-1.1 (m, 2H),
0.8-0.9 and 0.7-0.8 (m, 2H).
7-084 δ7.94 (s, 1H), 7.83 (s, 1H), 7.55-7.65 (m, 1H), 7.2-7.4 (m, 2H),
4.74 (d, J = 8.1Hz, 2H), 4.0-4.2 (m, 1H), 3.6-3.8 (m, 1H),
3.17 and 3.03 (s, 3H), 1.7-1.9 and 1.4-1.6 (m, 1H), 1.0-1.1 (m, 2H),
0.8-0.9 and 0.65-0.8 (m, 2H).
7-085 δ7.94 (d, J = 1.8Hz, 1H), 7.84 (s, 1H), 7.62 (d, J = 8.4Hz, 2H),
7.34 (d, J = 8.4Hz, 2H), 6.0-6.05 and 5.5-5.55 (m, 1H),
4.14 (d, J = 17.1Hz, 1H), 3.70 (d, J = 17.1Hz, 1H), 2.82 and 2.69 (s, 3H),
1.7-1.8 (m, 1H), 1.50 (d, J = 7.2Hz, 3H), 1.0-1.1 (m, 2H),
0.75-0.85 (m, 2H).
7-086 δ8.07 (s, 2H), 7.97 (s, 1H), 7.77 and 7.66 (d, J = 1.8Hz, 1H),
7.5-7.6 (m, 1H), 7.35-7.45 (m, 1H), 4.78 and 4.72 (s, 2H),
4.20 and 4.17 (d, J = 17.4Hz, 1H), 3.75 and 3.73 (d, J = 17.4Hz, 1H),
3.53 and 3.48 (q, J = 7.2Hz, 2H), 1.8-1.9 and 1.4-1.5 (m, 1H),
1.27 and 1.15 (t, J = 7.2Hz, 3H), 0.95-1.1 (m, 2H),
0.8-0.95 and 0.65-0.75 (m, 2H).
7-087 δ7.94 (s, 1H), 7.83 (s, 1H), 7.76 and 7.65 (s, 1H),
7.45-7.6 and 7.15-7.35 (m, 2H), 4.77 and 4.72 (s, 2H),
4.11 and 4.10 (d, J = 17.4Hz, 1H), 3.69 and 3.67 (d, J = 17.4Hz, 1H),
3.52 and 3.48 (q, J = 6.9Hz, 2H), 1.75-1.85 and 1.55-1.7 (m, 1H),
1.26 and 1.14 (t, J = 6.9Hz, 3H), 0.95-1.10 (m, 2H),
0.8-0.9 and 0.65-0.75 (m, 2H).
7-089 δ7.94 (s, 2H), 7.83 (s, 1H), 7.5-7.65 (m, 1H), 7.2-7.4 (m, 1H),
4.71 and 4.69 (s, 2H), 4.05-4.2 (m, 1H), 3.6-3.75 (m, 1H),
3.4-3.6 (m, 2H), 1.8-2.0 and 1.4-1.6 (m, 1H), 1.26 (t, J = 6.9Hz, 3H),
1.0-1.1 (m, 2H), 0.8-0.9 and 0.65-0.8 (m, 2H).
7-090 δ7.95 (d, J = 2.1Hz, 1H), 7.84 (s, 1H), 7.62 (d, J = 7.8Hz, 2H),
7.37 (d, J = 7.8Hz, 2H), 5.95-6.1 and 5.45-5.55 (m, 1H),
4.14 (d, J = 17.4Hz, 1H), 3.71 (d, J = 17.4Hz, 1H), 3.1-3.45 (m, 2H),
1.65-1.75 (m, 1H), 1.54 (d, J = 7.2Hz, 3H), 1.0-1.15 (m, 5H),
0.75-0.85 (m, 2H).
7-091 δ8.07 (s, 2H), 7.97 (s, 1H), 7.77 and 7.66 (d, J = 1.8Hz, 1H),
7.5-7.6 (m, 1H), 7.25-7.35 (m, 1H), 4.78 and 4.72 (s, 2H),
4.19 and 4.17 (d, J = 17.4Hz, 1H), 3.75 and 3.73 (d, J = 17.4Hz, 1H),
3.41 and 3.38 (t, J = 7.8Hz, 2H), 1.5-1.9 (m, 3H),
0.94 and 0.92 (t, J = 7.8Hz, 3H), 0.8-1.1 (m, 4H).
7-092 δ7.93 (s, 1H), 7.83 (s, 1H), 7.75 and 7.65 (d, J = 1.5Hz, 1H),
7.45-7.6 (m, 1H), 7.2-7.3 (m, 1H), 4.78 and 4.72 (s, 2H),
4.13 and 4.10 (d, J = 17.4Hz, 1H), 3.70 and 3.67 (d, J = 17.4Hz, 1H),
3.40 and 3.37 (t, J = 7.8Hz, 2H), 1.69 and 1.58 (sxt, J = 7.8Hz, 2H),
1.8-1.9 and 1.4-1.5 (m, 1H), 1.0-1.1 (m, 2H),
0.94 and 0.92 (t, J = 7.8Hz, 3H), 0.8-0.9 (m, 2H).
7-093 δ7.94 (s, 2H), 7.83 (s, 1H), 7.5-7.65 (m, 1H), 7.2-7.4 (m, 1H),
4.73 and 4.70 (s, 2H), 4.05-4.2 (m, 1H), 3.6-3.75 (m, 1H),
3.40 and 3.37 (t, J = 7.5Hz, 2H), 1.8-2.0 and 1.4-1.6 (m, 1H),
0.5-1.2 (m, 9H).
7-094 δ7.96 (s, 1H), 7.86 (s, 1H), 7.63 (d, J = 8.1Hz, 2H),
7.37 (d, J = 8.1Hz, 2H), 5.95-6.05 and 5.45-5.55 (m, 1H),
4.16 (d, J = 17.1Hz, 1H), 3.72 (d, J = 17.1Hz, 1H), 2.9-3.3 (m, 2H),
1.3-1.75 (m, 3H), 1.53 (d, J = 6.9Hz, 3H), 1.0-1.1 (m, 2H),
0.7-0.85 (m, 5H).
7-096 δ7.96 (s, 1H), 7.93 (s, 1H), 7.85 (s, 1H), 7.80 (s, 1H),
7.55-7.7 (m, 1H), 7.15-7.3 (m, 1H), 4.95, 4.89, 4.83 and 4.77 (s, 2H),
4.08 (d, J = 17.4Hz, 1H), 3.85-4.0 (m, 1H), 3.6-3.8 (m, 2H),
3.1-3.2 (m, 1H), 2.85-3.0 (m, 1H), 2.64 (s, 3H), 1.45-1.6 (m, 1H),
0.65-1.15 (m, 4H).
7-097 δ7.9-8.0 (m, 2H), 7.85 (s, 1H), 7.80 (s, 1H), 7.55-7.7 (m, 1H),
7.15-7.3 (m, 1H), 4.85 (s, 2H), 4.12 (d, J = 17.4Hz, 1H),
3.82 (t, J = 6.6Hz, 2H), 3.71 (d, J = 17.4Hz, 1H), 3.34 (t, J = 6.6Hz, 2H),
2.97 (s, 3H), 1.45-1.6 (m, 1H), 0.7-1.15 (m, 4H).
7-098 δ7.75-8.0 (m, 4H), 7.55-7.7 (m, 1H), 7.24 and 7.21 (s, 1H),
6.54 and 5.98 (bs, 1H), 4.76 and 4.72 (s, 2H), 4.05-4.2 (m, 1H),
3.35-3.75 (m, 5H), 1.94 and 1.92 (s, 3H), 1.4-1.55 (m, 1H),
0.7-1.1 (m, 4H).
7-099 δ7.74 and 7.67 (s, 1H), 7.45-7.6 (m, 4H), 7.43 (s, 1H),
5.03 and 4.69 (bs, 1H), 4.82 and 4.74 (s, 2H), 4.0-4.15 (m, 1H),
3.5-3.75 (m, 4H), 3.25-3.4 (m, 2H), 1.43 (s, 9H), 0.95-1.1 (m, 2H),
0.8-0.9 (m, 1H), 0.65-0.75 (m, 1H).
7-100 δ7.73 and 7.67 (s, 1H), 7.4-7.6 (m, 5H), 5.22 (bs, 1H),
4.82 and 4.73 (s, 2H), 4.59 and 4.24 (bs, 1H),
4.06 and 4.04 (d, J = 17.4Hz, 1H), 3.5-3.75 (m, 2H), 3.3-3.45 (m, 2H),
3.1-3.3 (m, 3H), 1.4-1.55 (m, 1H), 1.05-1.2 (m, 3H), 1.95-1.1 (m, 2H),
0.7-0.9 (m, 2H).
7-101 δ8.07 (s, 2H), 7.97 (s, 1H), 7.80 (s, 1H), 7.55-7.7 (m, 1H),
7.25-7.35 (m, 1H), 4.95 (s, 2H), 4.36 (s, 2H), 4.19 (d, J = 17.4Hz, 1H),
3.75 (d, J = 17.4Hz, 1H), 1.55-1.65 (m, 1H), 1.05-1.2 (m, 2H),
0.8-0.95 (m, 2H).
7-102 δ7.93 (d, J = 2.1Hz, 1H), 7.75-7.85 (m, 2H), 7.55-7.65 (m, 1H),
7.25-7.35 (m, 1H), 4.94 (s, 2H), 4.35 (s, 2H), 4.11 (d, J = 17.4Hz, 1H),
3.71 (d, J = 17.4Hz, 1H), 1.55-1.7 (m, 1H), 1.05-1.15 (m, 2H),
0.8-0.9 (m, 2H).
7-103 δ7.96 (s, 1H), 7.94 (s, 1H), 7.83 (s, 1H), 7.68 (d, J = 6.6Hz, 1H),
7.31 (d, J = 6.6Hz, 1H), 4.90 (s, 2H), 4.37 (s, 2H),
4.10 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H), 1.5-1.7 (m, 1H),
1.1-1.2 (m, 2H), 0.75-0.9 (m, 2H).
7-104 δ7.94 (s, 1H), 7.84 (s, 1H), 7.70 (d, J = 7.8Hz, 2H),
7.39 (d, J = 7.8Hz, 2H), 5.9-6.2 and 5.65-5.8 (m, 1H), 4.05-4.25 (m, 1H),
4.15 (d, J = 17.1Hz, 1H), 3.7-3.85 (m, 1H), 3.71 (d, J = 17.1Hz, 1H),
1.6-1.9 (m, 4H), 1.1-1.2 (m, 2H), 0.85-0.95 (m, 2H).
7-105 δ8.07 (s, 2H), 7.97 (s, 1H), 7.76 and 7.70 (s, 1H), 7.5-7.65 (m, 1H),
7.2-7.4 (m, 1H), 6.38 and 6.27 (bs, 1H), 6.19 and 5.94 (bs, 1H),
4.93 and 4.80 (s, 2H), 4.19 (d, J = 17.4Hz, 1H), 4.02 (s, 2H),
3.74 (d, J = 17.4Hz, 1H), 1.5-1.65 (m, 1H), 0.7-1.1 (m, 4H).
7-107 δ8.28 (bs, 1H), 7.93 (s, 1H), 7.83 (s, 1H), 7.73 (s, 1H),
7.5-7.65 (m, 2H), 7.15-7.25 (m, 1H), 4.81 (s, 2H), 4.37 (s, 2H),
4.12 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H), 2.32 (t, J = 7.5Hz, 2H),
1.6-1.75 (m, 2H), 0.93 (t, J = 7.5Hz, 3H).
7-108 δ8.07 (s, 2H), 7.97 (s, 1H), 7.77 and 7.66 (d, J = 1.5Hz, 1H),
7.5-7.6 (m, 1H), 7.25-7.35 (m, 1H), 5.7-5.9 (m, 1H), 5.1-5.3 (m, 2H),
4.76 and 4.72 (s, 2H), 4.20 and 4.17 (d, J = 17.4Hz, 1H),
4.0-4.1 (m, 2H), 3.75 and 3.73 (d, J = 17.4Hz, 1H),
1.75-1.85 and 1.45-1.55 (m, 1H), 1.0-1.1 (m, 2H),
1.8-1.9 and 1.65-1.75 (m, 2H).
7-109 δ7.94 (s, 1H), 7.84 (s, 1H), 7.76 and 7.65 (d, J = 1.5Hz, 1H),
7.5-7.6 (m, 1H), 7.25-7.35 (m, 1H), 5.7-5.95 (m, 1H), 5.1-5.3 (m, 2H),
4.76 and 4.72 (s, 2H), 4.08 (s, 2H), 4.07 (d, J = 17.4Hz, 1H),
3.71 and 3.69 (d, J = 17.4Hz, 1H), 1.7-1.85 (m, 1H), 0.95-1.1 (m, 2H),
0.75-0.9 and 0.65-0.75 (m, 2H).
7-110 δ7.94 (s, 2H), 7.82 (s, 1H), 7.55-7.7 (m, 1H), 7.2-7.4 (m, 1H),
5.7-6.0 (m, 1H), 5.1-5.35 (m, 2H), 4.70 (s, 2H), 4.0-4.2 (m, 3H),
3.70 and 3.67 (d, J = 17.4Hz, 1H), 1.8-2.0 and 1.4-1.6 (m, 1H),
1.0-1.1 (m, 2H), 0.8-0.9 and 0.65-0.8 (m, 2H).
7-111 δ7.94 (s, 1H), 7.84 (s, 1H), 7.62 (d, J = 8.4Hz, 2H),
7.36 (d, J = 8.4Hz, 2H), 6.0-6.15 and 5.4-5.55 (m, 1H), 5.65-5.8 (m, 1H),
5.15 (bs, 1H), 5.10 (bs, 1H), 4.15 (d, J = 17.1Hz, 1H), 3.9-4.05 (m, 1H),
3.6-3.75 (m, 1H), 3.71 (d, J = 17.1Hz, 1H), 1.65-1.75 (m, 1H),
1.50 (d, J = 6.9Hz, 3H), 1.0-1.1 (m, 2H), 0.75-0.85 (m, 2H).
7-112 δ8.08 (s, 2H), 7.97 (s, 1H), 7.77 and 7.67 (s, 1H), 7.5-7.6 (m, 1H),
7.3-7.45 (m, 1H), 4.94 and 4.81 (s, 2H),
4.31 and 4.22 (d, J = 2.4Hz, 2H), 4.19 and 4.17 (d, J = 17.4Hz, 1H),
3.75 and 3.73 (d, J = 17.4Hz, 1H), 2.31 and 2.20 (t, J = 2.4Hz, 1H),
1.85-1.95 and 1.45-1.55 (m, 1H), 1.0-1.2 (m, 2H),
0.9-1.0 and 0.7-0.85 (m, 2H).
7-113 δ7.93 (s, 1H), 7.83 (s, 1H), 7.75 and 7.66 (s, 1H), 7.45-7.6 (m, 1H),
7.3-7.4 (m, 1H), 4.94 and 4.81 (s, 2H), 4.31 and 4.23 (s, 2H),
4.13 and 4.11 (d, J = 17.4Hz, 1H), 3.72 and 3.69 (d, J = 17.4Hz, 1H),
2.31 and 2.20 (s, 1H), 1.55-1.75 (m, 1H), 1.0-1.1 (m, 2H),
0.99-1.0 and 0.7-0.8 (m, 2H).
7-114 δ7.94 (s, 2H), 7.83 (s, 1H), 7.55-7.7 (m, 1H), 7.2-7.4 (m, 1H),
4.88 and 4.79 (s, 2H), 4.31 and 4.20 (s, 2H), 4.1-4.2 (m, 1H),
3.6-3.75 (m, 1H), 2.32 and 2.20 (s, 1H), 1.8-2.0 and 1.4-1.6 (m, 1H),
1.0-1.1 (m, 2H), 0.8-0.9 and 0.65-0.8 (m, 2H).
7-115 δ7.95 (s, 1H), 7.85 (s, 1H), 7.64 (d, J = 7.8Hz, 2H),
7.39 (d, J = 7.8Hz, 2H), 6.0-6.15 and 5.5-5.6 (m, 1H), 3.9-4.4 (m, 2H),
4.16 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H), 2.23 (bs, 1H),
1.75-1.9 (m, 1H), 1.60 (bs, 3H), 1.05-1.15 (m, 2H), 0.85-1.0 (m, 2H).
7-116 δ8.08 (s, 2H), 7.97 (s, 1H), 7.78 and 7.67 (d, J = 1.8Hz, 1H),
7.5-7.6 (m, 1H), 7.2-7.35 (m, 1H), 4.72 and 4.60 (s, 2H),
4.20 and 4.18 (d, J = 17.4Hz, 1H), 3.76 and 3.74 (d, J = 17.4Hz, 1H),
3.44 and 3.35 (q, J = 7.2Hz, 2H), 2.05-2.3 (m, 3H),
1.19 and 1.15 (t, J = 7.2Hz, 3H), 1.00 and 0.91 (d, J = 6.3Hz, 6H).
7-117 δ8.08 (s, 2H), 7.97 (s, 1H), 7.77 and 7.67 (d, J = 1.8Hz, 1H),
7.5-7.6 (m, 1H), 7.28 and 7.18 (d, J = 8.4Hz, 1H), 4.73 and 4.60 (s, 2H),
4.20 and 4.17 (d, J = 17.4Hz, 1H), 3.76 and 3.74 (d, J = 17.4Hz, 1H),
3.34 and 3.22 (t, J = 7.5Hz, 2H), 2.2-2.35 (m, 1H),
2.35-2.25 and 2.05-2.15 (m, 2H), 1.5-1.7 (m, 2H),
1.00 and 0.91 (d, J = 7.2Hz, 6H), 0.92 (t, J = 7.5Hz, 3H).
7-118 δ8.08 (s, 2H), 7.98 (s, 1H), 7.81 (s, 1H), 7.55-7.8 (m, 1H),
7.2-7.3 (m, 1H), 4.78 (s, 2H), 4.32 (s, 2H), 4.20 (d, J = 17.4Hz, 1H),
3.76 (d, J = 17.4Hz, 1H), 2.2-2.4 (m, 3H),
1.01 and 0.97 (t, J = 6.9Hz, 6H).
7-119 δ8.08 (s, 2H), 7.97 (s, 1H), 7.78 and 7.68 (d, J = 1.5Hz, 1H),
7.5-7.6 (m, 1H), 7.28 and 7.25 (d, J = 7.8Hz, 1H), 4.82 and 4.77 (s, 2H),
4.20 and 4.18 (d, J = 17.4Hz, 1H), 4.27 and 4.04 (d, J = 2.4Hz, 2H),
3.76 and 3.74 (d, J = 17.4Hz, 1H), 2.29 and 2.20 (t, J = 2.4Hz, 1H),
2.15-2.3 (m, 1H), 2.38 and 2.13 (d, J = 6.6Hz, 2H),
1.01 and 0.92 (d, J = 6.3Hz, 6H).
7-121 δ8.07 (s, 2H), 7.97 (s, 1H), 7.75 and 7.67 (s, 1H), 7.5-7.6 (m, 1H),
7.3-7.4 and 7.2-7.25 (m, 1H), 5.65-5.9 (m, 1H), 5.1-5.3 (m, 2H),
4.72 and 4.56 (s, 2H), 4.19 and 4.17 (d, J = 17.4Hz, 1H),
4.03 and 3.88 (d, J = 4.8Hz, 2H), 3.73 and 3.72 (d, J = 17.4Hz, 1H),
2.35 and 2.20 (d, J = 6.6Hz, 2H), 1.1-1.2 (m, 1H), 0.5-0.7 (m, 2H),
0.05-0.25 (m, 2H).
7-122 δ8.08 (s, 2H), 7.97 (s, 1H), 7.55-7.8 (m, 2H), 7.1-7.45 (m, 6H),
4.73 and 4.62 (s, 2H), 4.52 (s, 2H), 4.19 and 4.17 (d, J = 17.4Hz, 1H),
3.75 and 3.73 (d, J = 17.4Hz, 1H), 2.41 and 2.25 (d, J = 6.6Hz, 2H),
1.05-1.25 (m, 1H), 0.5-0.7 (m, 2H), 0.05-0.25 (m, 2H).
7-124 δ8.08 (s, 2H), 7.98 (s, 1H), 7.80 (d, J = 1.8Hz, 1H), 7.55-7.65 (m, 1H),
7.38 and 7.36 (s, 1H), 4.61 (s, 2H), 4.54 (t, J = 5.4Hz, 1H),
4.34 (s, 2H), 4.19 (d, J = 17.4Hz, 1H), 3.75 (d, J = 17.4Hz, 1H),
3.28 (qd, J = 7.2, 5.4Hz, 2H), 1.10 (t, J = 7.2Hz, 3H).
7-125 δ8.07 (s, 2H), 7.96 (s, 1H), 7.68 (d, J = 1.5Hz, 1H), 7.5 and 7.6 (m, 1H),
7.35-7.45 (m, 1H), 5.7-5.9 (m, 1H), 5.15-5.35 (m, 2H), 4.61 (s, 2H),
4.42 (t, J = 4.8Hz, 1H), 4.17 (d, J = 17.4Hz, 1H), 3.85 (d, J = 4.8Hz, 2H),
3.73 (d, J = 17.4Hz, 1H), 3.26 (qd, J = 7.2, 4.8Hz, 2H),
1.11 (t, J = 7.2Hz, 3H).
7-127 δ8.07 (s, 2H), 7.97 (s, 1H), 7.57 (s, 1H), 7.25-7.55 (m, 3H),
5.28 and 4.84 (s, 2H), 4.16 (d, J = 17.4Hz, 1H), 3.71 (d, J = 17.4Hz, 1H),
3.75 and 3.25 (d, J = 7.2Hz, 2H), 2.65-2.85 (m, 1H), 0.9-1.15 (m, 1H),
0.75-0.9 (m, 2H), 0.45-0.7 (m, 4H), 0.15-0.3 (m, 2H).
8-003 δ7.8-8.5 (m, 4H), 7.50 (s, 2H), 7.45 (s, 1H), 4.09 (d, J = 17.4Hz, 1H),
3.72 (d, J = 17.4Hz, 1H), 1.45-1.55 (m, 1H),
1.55-1.8 and 1.15-1.3 (m, 1H), 0.7-1.2 (m, 8H).
8-004 δ8.37 and 8.25 (d, J = 2.1Hz, 1H), 7.85-7.95 (m, 2H), 7.50 (s, 2H),
7.41 (t, J = 1.5Hz, 1H), 6.91 and 6.72 (d, J = 8.7Hz, 1H),
4.05 and 4.01 (d, J = 17.4Hz, 1H), 3.66 and 3.63 (d, J = 17.4Hz, 1H),
3.49 and 3.38 (s, 3H), 1.75-1.85 and 1.45-1.55 (m, 1H),
1.05-1.15 (m, 2H), 0.85-0.95 (m, 2H).
8-005 δ7.60 (d, J = 8.1Hz, 2H), 7.50 (s, 2H), 7.42 (s, 1H),
7.25 (d, J = 8.1Hz, 2H), 5.92 (bs, 1H), 4.07 (d, J = 17.4Hz, 1H),
3.67 (d, J = 17.4Hz, 1H), 3.55 (q, J = 6.3Hz, 2H), 3.01 (q, J = 10.8Hz, 2H),
2.8-2.9 (m, 2H).
8-006 δ7.65 (d, J = 1.5Hz, 1H), 7.56 (dd, J = 8.1, 1.5Hz, 1H), 7.45-7.5 (m, 3H),
7.43 (t, J = 1.5Hz, 1H), 6.94 (s, 1H), 5.00 (bs, 1H), 4.11 (s, 2H),
4.06 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 2.2-2.35 (m, 1H),
1.12 (d, J = 7.2Hz, 6H).
8-007 δ7.69 (s, 1H), 7.45-7.55 (m, 4H), 7.43 (t, J = 1.5Hz, 1H), 7.35 (bs, 1H),
4.05 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H), 2.3-2.45 (m, 1H),
1.75-1.9 (m, 1H), 1.15 (d, J = 7.2Hz, 6H), 1.0-1.1 (m, 2H),
0.75-0.85 (m, 2H).
8-009 δ7.59 (d, J = 8.7Hz, 2H), 7.50 (d, J = 1.5Hz, 2H), 7.40 (t, J = 1.5Hz, 1H),
7.06 (d, J = 8.7Hz, 2H), 4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H),
3.15-3.3 (m, 2H), 1.55-1.7 (m, 2H), 1.35-1.45 (m, 2H),
0.9-1.4 (m, 12H).
8-010 (CDCl _Three , Me _Four Si, 500MHz) δ7.62 and 7.56 (d, J = 8.5Hz, 2H),
7.50 (d, J = 1.5Hz, 2H), 7.40 (t, J = 1.5Hz, 1H), 7.2-7.3 (m, 2H),
6.31 and 6.11 (s, 1H), 4.07 and 4.04 (d, J = 17.5Hz, 1H),
3.67 and 3.65 (d, J = 17.5Hz, 1H), 1.65-1.75 and 1.25-1.55 (m, 5H),
0.95-1.05 (m, 2H), 0.65-0.8 (m, 2H).
8-014 δ7.55 (d, J = 9.0Hz, 2H), 7.49 (bs, 2H), 7.40 (t, J = 2.1Hz, 1H),
7.23 (d, J = 9.0Hz, 2H), 6.17 (bs, 1H), 4.04 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 2.3-2.4 (m, 1H), 1.25-1.35 (m, 4H),
1.16 (d, J = 6.6Hz, 6H).
8-015 δ7.56 (d, J = 8.4Hz, 2H), 7.50 (d, J = 1.5Hz, 2H), 7.41 (t, J = 1.8Hz, 1H),
7.24 (d, J = 8.4Hz, 2H), 6.55 (s, 1H), 4.05 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H), 2.20 (d, J = 6.8Hz, 2H), 1.35 (s, 4H),
0.95-1.05 (m, 1H), 0.6-0.65 (m, 2H), 0.2-0.25 (m, 2H).
8-016 δ7.57 (d, J = 8.4Hz, 2H), 7.50 (d, J = 1.5Hz, 2H), 7.46 (s, 1H),
7.40 (t, J = 1.5Hz, 1H), 7.27 (d, J = 8.4Hz, 2H), 4.05 (d, J = 17.7Hz, 1H),
3.65 (d, J = 17.7Hz, 1H), 3.20 (s, 2H), 2.10 (s, 3H), 1.30 (bs, 4H).
8-017 δ8.1-8.15 (m, 1H), 7.81 (d, J = 8.4Hz, 2H), 7.49 (d, J = 1.5Hz, 2H),
7.40 (t, J = 1.8Hz, 1H), 7.32 (d, J = 8.4Hz, 2H), 6.95-7.05 (m, 1H),
6.85-6.9 (m, 1H), 4.05 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H),
1.45 (bs, 4H).
8-020 δ7.70 (d, J = 8.7Hz, 2H), 7.64 (s, 2H), 7.61 (d, J = 8.7Hz, 2H),
6.19 (s, 1H), 4.06 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H),
1.94 (s, 3H), 1.35-1.5 (m, 1H), 0.7-1.1 (m, 4H).
9-002 δ7.65 (d, J = 8.1Hz, 2H), 7.45-7.55 (m, 4H), 7.42 (t, J = 1.5Hz, 1H),
5.20 (bs, 1H), 4.09 (d, J = 17.4Hz, 1H), 3.91 (s, 2H),
3.68 (d, J = 17.4Hz, 1H), 2.48 (s, 3H).
9-003 δ7.62 (d, J = 8.1Hz, 2H), 7.51 (d, J = 1.5Hz, 2H), 7.35-7.45 (m, 3H),
4.09 (d, J = 17.4Hz, 1H), 3.84 (s, 2H), 3.68 (d, J = 17.4Hz, 1H),
2.67 (q, J = 6.9Hz, 2H), 1.14 (t, J = 6.9Hz, 3H).
9-004 δ7.62 (d, J = 8.1Hz, 2H), 7.51 (d, J = 1.5Hz, 2H), 7.46 (s, 1H),
7.4-7.45 (m, 2H), 4.07 (d, J = 17.4Hz, 1H), 3.85 (s, 2H),
3.68 (d, J = 17.4Hz, 1H), 2.8-2.95 (m, 1H), 1.14 (d, J = 6.6Hz, 6H).
9-005 (CDCl _Three , Me _Four Si, 400MHz) δ8.56 (d, J = 4.8Hz, 1H), 7.6-7.7 (m, 3H),
7.50 (s, 2H), 7.4-7.5 (m, 2H), 7.25-7.35 (m, 2H), 7.15-7.25 (m, 1H),
4.08 (d, J = 17.4Hz, 1H), 3.92 (s, 2H), 3.89 (s, 2H),
3.68 (d, J = 17.4Hz, 1H).
9-006 δ7.62 (d, J = 8.1Hz, 2H), 7.51 (d, J = 1.5Hz, 2H), 7.4-7.5 (m, 3H),
6.8-6.95 (m, 2H), 6.45-6.6 (m, 2H), 4.35 (s, 2H),
4.07 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H).
9-007 δ7.62 (d, J = 8.1Hz, 2H), 7.51 (d, J = 1.5Hz, 2H), 7.35-7.45 (m, 3H),
4.1-4.2 (m, 1H), 4.09 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H),
1.38 (d, J = 6.6Hz, 3H).
9-008 δ7.63 (d, J = 8.1Hz, 2H), 7.50 (d, J = 1.5Hz, 2H), 7.35-7.45 (m, 3H),
4.75-4.85 (m, 1H), 4.15-4.3 (m, 2H), 4.07 (d, J = 17.4Hz, 1H),
3.6-3.8 (m, 3H), 1.47 (d, J = 6.9Hz, 3H).
9-009 δ7.62 (d, J = 8.1Hz, 2H), 7.51 (d, J = 1.5Hz, 2H), 7.41 (t, J = 1.5Hz, 1H),
7.38 (d, J = 8.1Hz, 2H), 4.09 (d, J = 17.4Hz, 1H), 3.86 (t, J = 6.9Hz, 1H),
3.68 (d, J = 17.4Hz, 1H), 1.6-1.75 (m, 2H), 0.86 (t, J = 7.2Hz, 3H).
9-010 δ7.35-7.55 (m, 6H), 4.05 (d, J = 17.4Hz, 1H), 3.96 (s, 2H),
3.67 (d, J = 17.4Hz, 1H).
9-011 δ7.66 (d, J = 1.5Hz, 1H), 7.4-7.6 (m, 5H), 4.06 (d, J = 17.4Hz, 1H),
3.99 (s, 2H), 3.67 (d, J = 17.4Hz, 1H).
9-012 δ7.66 (d, J = 1.5Hz, 1H), 7.54 (dd, J = 8.1, 1.5Hz, 1H), 7.45-7.55 (m, 3H),
7.43 (t, J = 1.5Hz, 1H), 4.06 (d, J = 17.4Hz, 1H), 3.91 (s, 2H),
3.67 (d, J = 17.4Hz, 1H), 2.68 (q, J = 7.2Hz, 2H), 1.15 (t, J = 7.2Hz, 3H).
9-013 δ7.71 (d, J = 1.5Hz, 1H), 7.67 (bs, 1H), 7.56 (dd, J = 8.1, 1.5Hz, 1H),
7.50 (s, 2H), 7.43 (t, J = 1.5Hz, 1H), 7.38 (d, J = 8.1Hz, 1H),
4.07 (d, J = 17.4Hz, 1H), 3.85-4.0 (m, 4H), 3.68 (d, J = 17.4Hz, 1H),
3.36 (s, 2H).
9-014 δ7.67 (d, J = 1.5Hz, 1H), 7.54 (dd, J = 8.1, 1.5Hz, 1H), 7.45-7.55 (m, 3H),
7.43 (t, J = 1.5Hz, 1H), 5.90 (bs, 1H), 4.18 (s, 2H),
4.06 (d, J = 17.4Hz, 1H), 3.68 (d, J = 17.4Hz, 1H), 3.51 (s, 3H).
9-015 δ7.65 (d, J = 1.5Hz, 1H), 7.54 (dd, J = 8.1, 1.5Hz, 1H), 7.45-7.55 (m, 3H),
7.42 (t, J = 1.5Hz, 1H), 5.78 (bs, 1H), 4.17 (s, 2H),
4.05 (d, J = 17.4Hz, 1H), 3.6-3.75 (m, 3H), 1.12 (t, J = 6.9Hz, 3H).
9-018 δ7.84 (d, J = 1.5Hz, 1H), 7.62 (dd, J = 8.1, 1.5Hz, 1H), 7.45-7.55 (m, 3H),
7.43 (t, J = 1.5Hz, 1H), 4.06 (d, J = 17.4Hz, 1H), 3.99 (s, 2H),
3.67 (d, J = 17.4Hz, 1H).
9-020 δ7.35-7.55 (m, 6H), 4.08 (d, J = 17.4Hz, 1H), 3.90 (s, 2H),
3.68 (d, J = 17.4Hz, 1H), 2.35 (s, 3H).
9-021 δ8.19 (d, J = 1.5Hz, 1H), 7.98 (dd, J = 7.8, 1.5Hz, 1H),
7.78 (d, J = 7.8Hz, 1H), 7.51 (d, J = 1.5Hz, 2H), 7.44 (t, J = 1.5Hz, 1H),
4.18 (s, 2H), 4.11 (d, J = 17.4Hz, 1H), 3.73 (d, J = 17.4Hz, 1H).
9-023 δ7.66 (d, J = 1.5Hz, 1H), 7.54 (dd, J = 8.1, 1.5Hz, 1H),
7.50 (d, J = 1.5Hz, 2H), 7.47 (d, J = 8.1Hz, 1H), 7.42 (t, J = 1.5Hz, 1H),
4.06 (d, J = 17.4Hz, 1H), 3.87 (s, 2H), 3.67 (d, J = 17.4Hz, 1H),
2.46 (s, 3H).
9-024 δ7.65 (d, J = 1.5Hz, 1H), 7.4-7.55 (m, 5H), 4.07 (d, J = 17.4Hz, 1H),
3.96 (s, 2H), 3.67 (d, J = 17.4Hz, 1H), 2.05-2.15 (m, 1H),
0.35-0.5 (m, 4H).
9-025 δ7.65 (d, J = 1.5Hz, 1H), 7.45-7.55 (m, 4H), 7.42 (t, J = 1.5Hz, 1H),
4.07 (d, J = 17.4Hz, 1H), 3.93 (s, 2H), 3.68 (d, J = 17.4Hz, 1H),
2.48 (d, J = 6.9Hz, 2H), 0.95-1.05 (m, 1H), 0.45-0.55 (m, 2H),
0.05-0.15 (m, 2H).
9-027 δ7.65 (s, 1H), 7.45-7.55 (m, 4H), 7.42 (t, J = 1.5Hz, 1H),
4.06 (d, J = 17.4Hz, 1H), 3.93 (s, 2H), 3.67 (d, J = 17.4Hz, 1H),
3.52 (t, J = 5.1Hz, 2H), 3.36 (s, 3H), 2.81 (t, J = 5.1Hz, 2H).
9-029 δ7.87 (d, J = 2.4Hz, 1H), 7.75 (s, 1H), 7.54 (dd, J = 9.6, 2.4Hz, 1H),
7.45-7.55 (m, 4H), 7.25-7.45 (m, 2H), 6.58 (d, J = 9.6Hz, 1H),
4.65 (s, 2H), 4.04 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H).
9-030 δ8.08 (d, J = 1.5Hz, 1H), 7.63 (dd, J = 8.1, 1.5Hz, 1H),
7.50 (d, J = 1.5Hz, 2H), 7.45 (d, J = 8.1Hz, 2H), 7.44 (t, J = 1.5Hz, 1H),
4.05 (d, J = 17.4Hz, 1H), 3.82 (s, 2H), 3.67 (d, J = 17.4Hz, 1H),
3.47 (q, J = 7.2Hz, 2H), 1.15 (t, J = 7.2Hz, 3H).
9-032 δ8.07 (s, 2H), 7.96 (s, 1H), 7.67 (d, J = 1.5Hz, 1H),
7.57 (dd, J = 8.1, 1.5Hz, 1H), 7.50 (d, J = 8.1Hz, 1H),
4.18 (d, J = 17.4Hz, 1H), 3.98 (s, 2H), 3.72 (d, J = 17.4Hz, 1H).
9-033 δ7.83 (d, J = 1.5Hz, 1H), 7.63 (s, 2H), 7.60 (dd, J = 8.1, 1.5Hz, 1H),
7.49 (d, J = 8.1Hz, 1H), 4.06 (d, J = 17.4Hz, 1H), 3.95 (s, 2H),
3.66 (d, J = 17.4Hz, 1H).
9-034 δ8.18 (s, 1H), 7.97 (d, J = 8.4Hz, 1H), 7.78 (d, J = 8.4Hz, 1H),
7.64 (s, 2H), 4.18 (s, 2H), 4.11 (d, J = 17.4Hz, 1H),
3.73 (d, J = 17.4Hz, 1H).
9-035 δ8.85-9.0 (m, 1H), 8.05-8.2 (m, 1H), 7.55-7.7 (m, 2H), 7.55 (s, 2H),
7.45-7.55 (m, 2H), 7.43 (t, J = 1.8Hz, 1H), 4.37 (s, 2H),
4.26 (d, J = 17.4Hz, 1H), 3.98 (d, J = 17.4Hz, 1H).
9-036 δ8.00 (d, J = 7.8Hz, 1H), 7.82 (s, 1H), 7.64 (s, 2H),
7.62 (d, J = 7.8Hz, 1H), 4.29 (s, 2H), 4.09 (d, J = 17.4Hz, 1H),
3.74 (d, J = 17.4Hz, 1H), 2.59 (s, 3H).
9-038 δ7.6-7.65 (m, 3H), 7.45-7.55 (m, 2H), 4.07 (d, J = 17.1Hz, 1H),
3.90 (s, 2H), 3.67 (d, J = 17.1Hz, 1H), 2.59 (t, J = 7.2Hz, 2H),
1.54 (sxt, J = 7.2Hz, 2H), 0.93 (t, J = 7.2Hz, 3H).
9-039 δ7.64 (s, 1H), 7.63 (s, 2H), 7.45-7.55 (m, 2H), 4.06 (d, J = 17.1Hz, 1H),
3.90 (s, 2H), 3.66 (d, J = 17.1Hz, 1H), 2.62 (t, J = 7.2Hz, 2H),
1.3-1.55 (m, 4H), 0.91 (t, J = 7.2Hz, 3H).
9-040 δ7.64 (s, 1H), 7.63 (s, 2H), 7.54 (d, J = 9.0Hz, 1H),
7.50 (d, J = 9.0Hz, 1H), 4.06 (d, J = 17.1Hz, 1H), 3.93 (s, 2H),
3.66 (d, J = 17.1Hz, 1H), 2.48 (d, J = 6.9Hz, 2H), 0.9-1.05 (m, 1H),
0.45-0.55 (m, 2H), 0.05-0.15 (m, 2H).
9-041 δ7.65 (s, 1H), 7.45-7.6 (m, 4H), 7.42 (t, J = 1.5Hz, 1H),
4.05 (d, J = 17.4Hz, 1H), 3.93 (s, 2H), 3.68 (d, J = 17.4Hz, 1H),
2.83 (t, J = 6.0Hz, 2H), 2.69 (t, J = 6.0Hz, 2H), 2.08 (s, 3H).
9-042 δ7.66 (s, 1H), 7.63 (s, 2H), 7.53 (s, 2H), 4.06 (d, J = 17.1Hz, 1H),
4.01 (s, 2H), 3.66 (d, J = 17.1Hz, 1H), 3.46 (d, J = 2.4Hz, 2H),
2.28 (t, J = 2.4Hz, 1H).
9-043 δ7.65 (s, 1H), 7.45-7.55 (m, 4H), 7.40 (s, 1H), 7.2-7.35 (m, 2H),
6.95-7.05 (m, 2H), 4.07 (d, J = 17.4Hz, 1H), 3.90 (s, 2H), 3.76 (s, 2H),
3.67 (d, J = 17.4Hz, 1H), 1.81 (s, 1H).
9-044 δ7.75 (d, J = 1.5Hz, 1H), 7.64 (s, 2H), 7.59 (dd, J = 7.8, 1.5Hz, 1H),
7.51 (d, J = 7.8Hz, 1H), 4.35 (d, J = 6.0Hz, 2H), 4.05 (d, J = 17.4Hz, 1H),
4.01 (bs, 1H), 3.68 (d, J = 17.4Hz, 1H).
9-045 δ8.10 (d, J = 7.8Hz, 1H), 7.87 (s, 1H), 7.66 (d, J = 7.8Hz, 1H),
7.64 (s, 2H), 5.20 (s, 2H), 4.09 (d, J = 17.4Hz, 1H),
3.73 (d, J = 17.4Hz, 1H), 3.57 (s, 6H).
9-047 δ7.62 (d, J = 8.1Hz, 2H), 7.52 (d, J = 1.5Hz, 2H), 7.39 (d, J = 8.1Hz, 2H),
7.41 (t, J = 1.5Hz, 1H), 4.10 (d, J = 17.1Hz, 1H), 3.75-3.85 (m, 1H),
3.70 (d, J = 17.1Hz, 1H), 2.45-2.55 (m, 2H), 1.35 (d, J = 6.6Hz, 3H),
1.05 (t, J = 6.9Hz, 3H).
9-048 δ7.72 (d, J = 8.4Hz, 2H), 7.64 (s, 2H), 7.63 (d, J = 8.4Hz, 2H),
4.95 (s, 1H), 4.09 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H).
9-049 δ7.91 (d, J = 1.5Hz, 1H), 7.73 (dd, J = 8.4, 1.5Hz, 1H),
7.67 (d, J = 1.5Hz, 1H), 7.61 (d, J = 8.4Hz, 1H),
7.56 (dd, J = 8.1, 1.5Hz, 1H), 7.50 (d, J = 8.1Hz, 1H),
4.11 (d, J = 17.4Hz, 1H), 3.97 (s, 2H), 3.69 (d, J = 17.4Hz, 1H).
9-050 δ7.66 (d, J = 1.8Hz, 1H), 7.64 (s, 2H), 7.56 (dd, J = 7.8, 1.8Hz, 1H),
7.50 (d, J = 7.8Hz, 1H), 6.61 (t, J = 73.5Hz, 1H), 4.08 (d, J = 17.4Hz, 1H),
3.98 (s, 2H), 3.68 (d, J = 17.4Hz, 1H).
9-051 δ8.08 (s, 2H), 7.97 (s, 1H), 7.69 (d, J = 1.5Hz, 1H),
7.56 (dd, J = 7.8, 1.5Hz, 1H), 7.50 (d, J = 7.8Hz, 1H),
4.19 (d, J = 17.4Hz, 1H), 3.88 (s, 2H), 3.73 (d, J = 17.4Hz, 1H),
2.47 (s, 3H).
9-052 δ8.08 (s, 2H), 7.97 (s, 1H), 7.68 (d, J = 1.5Hz, 1H),
7.55 (dd, J = 8.1, 1.5Hz, 1H), 7.51 (d, J = 8.1Hz, 1H),
4.18 (d, J = 17.4Hz, 1H), 3.92 (s, 2H), 3.73 (d, J = 17.4Hz, 1H),
2.68 (q, J = 7.2Hz, 2H), 1.15 (t, J = 7.2Hz, 3H).
9-053 δ8.07 (s, 2H), 7.96 (s, 1H), 7.68 (d, J = 1.8Hz, 1H), 7.45-7.6 (m, 2H),
4.18 (d, J = 17.4Hz, 1H), 3.91 (s, 2H), 3.73 (d, J = 17.4Hz, 1H),
2.59 (t, J = 7.2Hz, 2H), 1.53 (qui, J = 7.2Hz, 2H), 1.48 (bs, 1H),
0.93 (t, J = 7.2Hz, 3H).
9-054 δ8.07 (s, 2H), 7.96 (s, 1H), 7.67 (d, J = 1.5Hz, 1H), 7.5-7.6 (m, 2H),
4.18 (d, J = 17.4Hz, 1H), 3.93 (s, 2H), 3.73 (d, J = 17.4Hz, 1H),
2.49 (d, J = 6.9Hz, 2H), 1.60 (bs, 1H), 0.9-1.05 (m, 1H),
0.45-0.55 (m, 2H), 0.05-0.15 (m, 2H).
9-055 δ8.07 (s, 2H), 7.96 (s, 1H), 7.68 (d, J = 1.5Hz, 1H), 7.5-7.6 (m, 2H),
4.18 (d, J = 17.4Hz, 1H), 4.01 (s, 2H), 3.73 (d, J = 17.4Hz, 1H),
3.46 (d, J = 2.4Hz, 2H), 2.28 (t, J = 2.4Hz, 1H), 1.61 (bs, 1H).
9-056 δ7.94 (s, 1H), 7.83 (s, 1H), 7.67 (s, 1H), 7.5-7.6 (m, 2H),
4.12 (d, J = 17.4Hz, 1H), 3.97 (s, 2H), 3.68 (d, J = 17.4Hz, 1H),
2.74 (q, J = 7.2Hz, 2H), 1.20 (t, J = 7.2Hz, 3H).
9-058 δ8.08 (s, 2H), 7.96 (s, 1H), 7.67 (d, J = 1.8Hz, 1H), 7.5-7.6 (m, 2H),
4.19 (d, J = 17.4Hz, 1H), 3.90 (s, 2H), 3.75 (d, J = 17.4Hz, 1H),
2.42 (d, J = 6.6Hz, 2H), 1.77 (sep, J = 6.6Hz, 1H), 0.92 (d, J = 6.6Hz, 6H).
9-059 δ7.67 (bs, 1H), 7.4-7.6 (m, 5H), 6.02 (bs, 1H), 4.06 (d, J = 17.4Hz, 1H),
3.91 (s, 2H), 3.67 (d, J = 17.4Hz, 1H), 3.36 (dd, J = 11.4, 5.7Hz, 2H),
2.76 (t, J = 6.3Hz, 2H), 1.99 (s, 3H).
9-060 δ7.97 (s, 1H), 7.8-7.9 (m, 2H), 7.80 (s, 1H), 7.55-7.7 (m, 1H),
7.4-7.5 (m, 1H), 5.96 (bs, 1H), 4.09 (d, J = 17.4Hz, 1H), 3.89 (s, 2H),
3.70 (d, J = 17.4Hz, 1H), 3.36 (dd, J = 11.4, 5.7Hz, 2H), 2.7-2.85 (m, 2H),
1.96 (s, 3H).
9-061 δ7.67 (bs, 1H), 7.4-7.6 (m, 5H), 4.87 (bs, 1H), 4.06 (d, J = 17.4Hz, 1H),
3.91 (s, 2H), 3.67 (d, J = 17.4Hz, 1H), 3.25 (dd, J = 11.4, 5.7Hz, 2H),
2.75 (t, J = 6.3Hz, 2H), 1.44 (s, 9H).
9-062 δ8.09 (s, 2H), 7.98 (s, 1H), 7.72 (d, J = 1.8Hz, 1H),
7.60 (dd, J = 7.8, 1.8Hz, 1H), 7.52 (d, J = 7.8Hz, 1H),
4.20 (d, J = 17.4Hz, 1H), 4.06 (s, 2H), 3.76 (d, J = 17.4Hz, 1H),
3.64 (s, 2H), 1.72 (bs, 1H).
9-063 δ7.94 (d, J = 1.5Hz, 1H), 7.83 (s, 1H), 7.76 (s, 1H), 7.5-7.6 (m, 2H),
4.12 (d, J = 17.4Hz, 1H), 4.05 (s, 2H), 3.69 (d, J = 17.4Hz, 1H),
3.62 (s, 2H), 1.73 (bs, 1H).
9-064 δ8.08 (s, 2H), 7.97 (s, 1H), 7.68 (d, J = 0.9Hz, 1H), 7.5-7.6 (m, 2H),
4.18 (d, J = 17.4Hz, 1H), 3.94 (s, 2H), 3.74 (s, 3H),
3.73 (d, J = 17.4Hz, 1H), 3.45 (s, 2H), 1.98 (bs, 1H).
9-065 δ8.09 (s, 2H), 7.97 (s, 1H), 7.68 (d, J = 1.8Hz, 1H), 7.5-7.6 (m, 2H),
5.92 (ddt, J = 17.4, 10.5, 6.0Hz, 1H), 5.1-5.3 (m, 2H),
4.21 (d, J = 17.4Hz, 1H), 3.91 (s, 2H), 3.77 (d, J = 17.4Hz, 1H),
3.28 (d, J = 6.0Hz, 2H), 1.67 (bs, 1H).
9-066 δ7.94 (d, J = 1.5Hz, 1H), 7.83 (s, 1H), 7.76 (s, 1H), 7.5-7.6 (m, 2H),
5.92 (ddt, J = 17.4, 10.5, 6.0Hz, 1H), 5.1-5.3 (m, 2H),
4.12 (d, J = 17.4Hz, 1H), 3.91 (s, 2H), 3.69 (d, J = 17.4Hz, 1H),
3.28 (d, J = 6.0Hz, 2H), 1.53 (bs, 1H).
9-070 δ7.64 (d, J = 7.8Hz, 1H), 7.45-7.6 (m, 4H), 7.42 (t, J = 4.5Hz, 1H),
5.02 (bs, 1H), 4.08 (d, J = 17.4Hz, 1H), 3.69 (d, J = 17.4Hz, 1H),
2.48 (s, 3H), 1.91 (bs, 2H).
9-071 δ7.60 (m, 2H), 7.45-7.5 (m, 4H), 7.4-7.45 (m, 1H), 6.97 (bs, 1H),
5.58 (bs, 1H), 4.58 (s, 1H), 4.07 (d, J = 17.4Hz, 1H),
3.67 (d, J = 17.4Hz, 1H), 1.77 (bs, 2H).
11-002 δ7.75-7.85 (m, 2H), 7.65-7.75 (m, 2H), 7.63 (d, J = 8.1Hz, 2H),
7.45-7.6 (m, 4H), 5.58 (q, J = 7.5Hz, 1H), 5.1-5.25 (m, 1H),
4.05 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H), 1.91 (d, J = 6.6Hz, 3H).
11-003 δ7.75-7.85 (m, 2H), 7.65-7.75 (m, 2H), 7.55-7.65 (m, 4H),
7.49 (d, J = 1.5Hz, 2H), 7.41 (t, J = 1.5Hz, 1H),
5.26 (dd, J = 6.9, 6.6Hz, 1H), 4.05 (d, J = 17.4Hz, 1H),
3.66 (d, J = 17.4Hz, 1H), 2.45-2.65 (m, 1H), 2.25-2.45 (m, 1H),
0.97 (t, J = 7.2Hz, 3H).
11-004 δ7.8-7.95 (m, 2H), 7.7-7.8 (m, 2H), 7.48 (d, J = 1.5Hz, 2H),
7.35-7.45 (m, 4H), 4.95 (s, 2H), 4.02 (d, J = 17.4Hz, 1H),
3.64 (d, J = 17.4Hz, 1H).
11-005 δ7.85-7.95 (m, 2H), 7.75-7.85 (m, 2H), 7.4-7.7 (m, 5H),
7.25-7.35 (m, 1H), 5.00 (s, 2H), 4.03 (d, J = 17.4Hz, 1H),
3.65 (d, J = 17.4Hz, 1H).
11-007 δ7.7-8.1 (m, 4H), 7.35-7.7 (m, 4H), 7.15-7.35 (m, 2H), 4.98 (s, 2H),
4.03 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H).
11-009 δ7.8-7.95 (m, 2H), 7.7-7.85 (m, 2H), 7.45-7.55 (m, 3H),
7.35-7.45 (m, 1H), 7.25-7.45 (m, 2H), 4.87 (s, 2H),
4.04 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H), 2.51 (s, 3H).
11-013 δ8.05 (s, 2H), 7.95 (s, 1H), 7.85-7.95 (m, 2H), 7.7-7.8 (m, 2H),
7.68 (d, J = 1.5Hz, 1H), 7.52 (dd, J = 8.1, 1.5Hz, 1H),
7.28 (d, J = 8.1Hz, 1H), 5.00 (s, 2H), 4.14 (d, J = 17.4Hz, 1H),
3.69 (d, J = 17.4Hz, 1H).
11-015 δ7.8-7.95 (m, 4H), 7.7-7.8 (m, 2H), 7.4-7.5 (m, 4H), 5.10 (s, 2H),
4.04 (d, J = 17.4Hz, 1H), 3.67 (d, J = 17.4Hz, 1H).
11-017 δ8.07 (s, 2H), 7.94 (s, 1H), 7.75-7.85 (m, 2H), 7.65-7.75 (m, 2H),
7.64 (d, J = 8.4Hz, 2H), 7.55 (d, J = 8.4Hz, 2H), 5.58 (q, J = 7.2Hz, 1H),
4.17 and 4.16 (d, J = 17.4Hz, 1H), 3.71 (d, J = 17.4Hz, 1H),
1.92 (d, J = 7.2Hz, 3H).
11-018 δ7.75-7.85 (m, 2H), 7.65-7.75 (m, 2H), 7.62 (s, 2H),
7.61 (d, J = 8.7Hz, 2H), 7.55 (d, J = 8.7Hz, 2H), 5.58 (q, 1H),
4.05 and 4.04 (d, J = 17.4Hz, 1H), 3.65 (d, J = 17.4Hz, 1H),
1.92 (d, J = 7.5Hz, 3H).
11-019 δ7.85-7.95 (m, 3H), 7.75-7.85 (m, 2H), 7.72 (dd, J = 8.4, 1.5Hz, 1H),
7.68 (d, J = 1.5Hz, 1H), 7.60 (d, J = 8.1Hz, 1H),
7.51 (dd, J = 8.1, 1.5Hz, 1H), 7.28 (d, J = 8.1Hz, 1H), 5.00 (s, 2H),
4.08 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H).
11-020 δ7.85-7.95 (m, 2H), 7.7-7.8 (m, 2H), 7.67 (d, J = 1.8Hz, 1H),
7.62 (s, 2H), 7.49 (dd, J = 8.1, 1.8Hz, 1H), 7.27 (d, J = 8.1Hz, 1H),
6.59 (t, J = 74.1Hz, 1H), 5.00 (s, 2H), 4.04 (d, J = 17.4Hz, 1H),
3.64 (d, J = 17.4Hz, 1H).
11-021 δ7.85-7.95 (m, 3H), 7.75-7.85 (m, 3H), 7.68 (d, J = 1.5Hz, 1H),
7.51 (dd, J = 8.1, 1.5Hz, 1H), 7.28 (d, J = 8.1Hz, 1H), 5.00 (s, 2H),
4.09 (d, J = 17.4Hz, 1H), 3.66 (d, J = 17.4Hz, 1H).
―――――――――――――――――――――――――――――――――――――――
[Test example]
Next, the usefulness of the compounds of the present invention as pest control agents will be specifically described in the following test examples, but the present invention is not limited to these examples.

Test Example 1 Insecticidal test against the diamondback moth A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. Soak kanran leaves in this chemical solution for about 10 seconds, air dry and place in a petri dish. 5 second instar larvae of Plutella xylostella are released per petri dish, then covered and placed in a constant temperature room at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the dead insect rate was calculated from the following formula. In addition, the test was performed by 2 continuous systems.

Death rate (%) = (Number of dead insects / Number of dead insects) × 100
As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No.1-001 ^* , 1-002 ^* , 1-003 ^* , 1-004,1-005 ^* , 1-006 ^* , 1-007 ^* , 1-008 ^* , 1-009 ^* , 1-010,1-011,1-013 ~ 1-015,1-017 ~ 1-019,1-020 ^* , 1-021,1-022 ^* , 1-023 ^* , 1-024 ^* , 1- 025,1-026 ^* , 1-027,1-028 ^* , 1-029 ^* , 1-031,1-032 ^* , 1-033〜1-052,1-053 ^* , 1-054〜1-061 , 1-062 ^* , 1-063 ^** , 1-064 ^** , 1-065 ^** , 1-066,1-067,1-068 ^** , 1-069 ^** , 1-070,1- 071,1-072 ^** , 1-073 ^** , 1-074 ^* , 1-075 ^** , 1-076 to 1-078,1-079 ^* , 1-080 to 1-085,1-086 ^{* *} , 1-087 to 1-090,1-091 ^* , 1-092,1-093 ^** , 1-094,1-095,1-096 ^** , 1-097,1-098 ^** , 1 -099 ~ 1-103,1-104 ^* , 1-105 ~ 1-114,1-116 ^* , 1-117,1-118 ^** , 1-119,2-001 ^* , 2-002 ^* , 2 -003,2-004,2-005 ^* , 2-006 ^* , 2-007 ^* , 2-008,2-009 ^* , 2-010 ^* , 2-011,2-012,2-014,2- 015,2-016 ^* , 2-017 ^* , 2-017 (a), 2-017 (d) ^** , 2-018 ^* , 2-019 ^* , 2-020,2-021 ^* , 2-022 ^* , 2-023 ~ 2-025,2-026 ^** , 2-027 ^** , 2-028 ^** , 2-029,2-030,2-031 ^** , 2-032 ^* , 2-033 ^* , 2-034 ^** , 2-035 ^** , 2-036 ^** , 2-037 ^* , 2-038 ^** , 2-039,2-040,2-041 ^** , 2-042 ^** , 2-043 ^* , 2-044 ^* , 2-045 ^* , 2-046 ^* , 2-047 to 2-050,2-051 ^* , 2-052,2-053 ^* , 2-054 ^* , 2-055 ^* , 2-056,2-057 ^* , 2-058,2-059 ^** , 2-060 ^* , 2-061 ^** , 2 -062 ^** , 2-063 ^** , 2-064,2-065 ^* , 2-066 ^** , 2-067,2-068 ^** , 2-069 ^** , 2-070 ^** , 2- 071,2-072 ^* , 2-073 ^** , 2-074,2-075,2-076 ^* , 2-077 ^* , 2-078 ^* , 2-079 ^** , 2-080 ^** , 2- 081 ^** , 2-082 ^** , 2-083 ^** , 2-084,2-085 ^** , 2-086 ^* , 2-087 ^** , 2-089,2-090 ^* , 2-091, 2-092 ^** , 2-093 ^** , 2-094,2-095 ^** , 2-096 ^* , 2-097 ^** , 2-098 ^* , 2-099 ^** , 2-100 ^** , 2-101, 2-102, 2-103 ^** , 2-104 ^** , 2-105 ^** , 2-106 ^** , 2-107 ^** , 2-108 ^** , 2-109 ^** , 2-110 ^**, 2-111 ^**, 2-112 ^**, 2-113 ^**, 2-114 ^**, 2-115 ^**, 2-116 ^**, 2-117 ^**, 2- 118 ^**, 2-119 ^**, 2-120 ^**, 2-121 ^**, 2-122 ^**, 2-124 ^**, 2-125～2-128,2-129 ^**, 2- 130 ^** , 2-131 ^** , 2-132 ^** , 2-133 ^** , 2-134 ^** , 2-135 ^* , 2-136, 2-137 ^** , 2-138 ^** , 2 -139 ^**, 2-140 ^**, 2-141 ^**, 2-142 ^**, 2-143 ^**, 2-144 ^**, 2-145 ^**, 2-146 ^**, 2-147 ^** , 2-148 ^** , 2-149 ^** , 2-150 ^** , 2-151 ^** , 2-152 ^** , 2-153 ^** , 2-154 ^** , 2-155 ^** , 2-156 ^* , 2-157, 2-158, 2-159 ^** , 2-160 ^** , 2-161 ^** , 2-163 ^** , 2-164 ^** , 2-165 ^** , 2-166 ^** , 2-167 ^** , 2-168 ^** , 2-169 ^* , 2-170 ^** , 2-171 ^** , 2-172 ^** , 2-173 ^** , 2-174 ^**, 2-175 ^*, 2-176 ^**, 2-177 ^**, 2-178 ^**, 2-179 ^**, 2-180 ^**, 2-181 ^*, 2-182 ^**, 2 -183 ^** , 2-184 ^** , 2-185 ^** , 2-186 ^* , 2-187 ^* , 2-188 to 2-191, 2-192 ^** , 2-193 ^** , 2-194 ^**, 2-195,2-196,2-197 ^**, 2-198,2-199 ^**, 2-200 ^**, 2-201 ^**, 2-202 ^*, 2-203 ^**, 2-204 ^*, 2-205 ^*, 2-206 ^*, 2-207 ^**, 2-208 ^*, 2-209 ^**, 2-210 ^*, 2-211～2-214,2-215 ^** , 2-216,2-217 ^** , 2-218 ^** , 2-219 ^** , 2-220 ^* , 2-221 ^** , 2-222 ^** , 2-223 ^** , 2-224 ^{* *} , 2-225 ^** , 2-226 ^** , 2-227 ^** , 2-228, 2-229, 2-230 ^** , 2-231 ^** , 2-232 ^** , 2-233 ^* , 2-234 ^**, 2-235 ^**, 2-236～2-239,2-240 ^*, 2-241,2-242 ^*, 2-243,2-244 ^*, 2-245 ^*, 2 -246,2-247,2-248 ^** , 2-249-2-252,2-253 ^** , 2-254 ^** , 2-255 ^* , 2-256,2-257,2-258 ^{* *} , 2-259 to 2-261,2-262 ^** , 2-263 ^** , 2-264,2-265 ^** , 2-266 ^** , 2-267 ^* , 2-268 ^** , 2 -269 ^*, 2-270 ^*, 2-271 ^**, 2-272 ^**, 2-273 ^*, 2-274 ^**, 2-275 ^**, 2-276 ^**, 2-277 ^**, 2-278 ^* , 2-279 ^** , 2-280 ^** , 2-281 ^** , 2-282 ^** , 2-283 ^** , 2-284 ^** , 2-285 ^** , 2-286 ^* , 2-287 ^** , 2-288 ^** , 2-289 ^** , 2-290 ^** , 2-291,2-292,2-293 ^* , 2-294 ^* , 2-295,2-296 ^* , 2-297,2-298,2-299 ^** , 2-300,2-301 ^* , 2-302,2-303,2-304 ^** , 2-305 ^{* *} , 2-306,2-307 ^* , 2-308 ^* , 2-309 ^** , 2-310 ^** , 2-311 ^** , 2-312 ^* , 2-313 ^* , 2-314 ^** , 2-315 ^** , 2-316 ^** , 2-317 ^** , 2-318 ^** , 2-319 ^** , 2-320 ^** , 2-321 ^** , 2-322 ^** , 2- 323 ^**, 2-324 ^**, 2-325 ^**, 2-326 ^**, 2-327 ^**, 2-328 ^**, 2-329 ^**, 2-330 ^**, 2-331 ^{* *} , 2-332 ^* , 2-333 ^** , 2-334 ^** , 2-335 ^* , 2-336 ^* , 2-337 ^* , 2-338 ^* , 2-339 ^* , 2-340 ^* , 2 -341 ^** , 2-342 ^* , 2-343 ^** , 2-344 ^** , 2-345 ^** , 2-346,2-347 ^* , 2-348 ^* , 2-349 ^* , 2-350 ^** , 2-351 ^** , 2-352 ^** , 2-353 ^* , 2-356 ^** , 2-357 ^* , 2-358 ^* , 2-359 ^** , 2-360 ^* , 2-361 ^** , 2-362 ^* , 2-363 ^* , 2-364 ^* , 2-365 ^** , 2-366 ^** , 2-367 ^** , 2-368 ^** , 2-369 ^* , 2-371 ^** , 2-372 ^* , 2-374 ^** , 2-375 ^* , 2-376 ^* , 2-377 ^* , 2-378 ^** , 2-379 ^** , 2-380 ^** , 2-381 ^* , 2-382 ^** , 2-383 ^** , 2-384 ^* , 2-385 ^** , 2-386 ^* , 2-387 ^* , 2-388 ^* , 2-389 ^** , 2-390 ^{* *} , 2-391 ^** , 2-392 ^** , 2-394 ^* , 2-396 ^** , 2-397 ^* , 2-398 ^* , 2-399 ^**, 2-400 ^**, 2-401 ^*, 2-402 ^*, 2-403 ^*, 2-404 ^**, 2-405 ^**, 2-406 ^**, 2-407 ^**, 2- 408 ^* , 2-410 ^** , 2-411 ^* , 2-413 ^** , 2-414 ^* , 2-415 ^* , 2-416 ^* , 2-417 ^** , 2-418 ^** , 2-419 ^** , 2-420 ^** , 2-421 ^** , 2-422 ^* , 2-423 ^* , 2-424 ^** , 2-425 ^* , 2-426 ^** , 2-427 ^** , 2- 428 ^* , 2-430 ^** , 2-431 ^** , 2-433 ^** , 2-434 ^** , 2-435 ^** , 2-436 ^* , 2-437 ^* , 2-438 ^** , 2 -439 ^** , 2-440 ^** , 2-441 ^** , 2-442 ^** , 2-443 ^** , 2-444 ^* , 2-445,2-446 ^** , 2-447 ^* , 2 -448 ^* , 2-449 ^** , 2-450 ^** , 2-451 ^** , 2-452 ^** , 2-453,2-454 ^* , 2-455 ^* , 2-456 ^* , 2-457 ^** , 2-458 ^** , 2-459 ^** , 2-460 ^** , 2-461 ^* , 2-463 ^** , 2-465 ^** , 2-466 ^* , 2-467 ^* , 2- 468 ^* , 2-469 ^** , 2-470 ^** , 2-471 ^* , 2-472 ^* , 2-473 ^* , 2-474 ^** , 2-475 ^** , 2-476 ^** , 2- 477 ^* , 2-478 ^** , 2-479 ^** , 2-480 ^** , 2-481 ^* , 2-482 ^** , 2-483 ^* , 2-484 ^** , 2-485 ^* , 2- 486,2-487 ^* , 2-488 ^** , 2-489 ^** , 2-490 ^** , 2-491 ^* , 2-492 ^** , 2-493 ^** , 2-494 ^* , 2-495 ^*, 2-496 ^**, 2-497 ^*, 2-498 ^*, 2-499 ^**, 2-500 ^**, 2-501 ^**, 2-502 ^**, 2-503 ^**, 2- 504 ^** , 2-505 ^* , 2-506 ^* , 2-507 to 2-509, 2-510 ^* , 2-511 ^* , 2-51 2 ^** , 2-513,2-514 ^* , 2-515 ^** , 2-516 ^** , 2-517 ^** , 2-518 ^* , 2-519 ^* , 2-520 ^* , 2-521 ^* , 2-522 ^* , 2-523 ^* , 2-524 ^* , 2-525 ^** , 2-526 ^* , 2-527 ^* , 2-528 ^** , 2-529,2-530,2-531 ^{* *} , 2-532 ^** , 2-533,2-534 ^* , 2-535 ^* , 2-536 ^** , 3-001 ^* , 3-002,3-003 ^* , 3-004 ^** , 3- 005 ^* , 3-006 ^* , 3-007 ^** , 3-008 ^** , 3-009 ^* , 3-010 ^** , 3-011 ^** , 3-012 ^* , 3-013 ^* , 3-014 ^*, 3-015 ^*, 4-001 ^*, 4-002 ^*, 4-003 ^*, 4-004 ^**, 4-005 ^**, 4-006 ^*, 4-007 ^*, 4-008 ^*, 4 -009 ^* , 4-010 ^* , 4-011 ^* , 4-012 ^** , 4-013 ^** , 4-014 ^* , 4-015 ^* , 4-016 ^** , 4-017 ^** , 4- 018 ^** , 4-019 ^** , 4-020 ^** , 4-021 ^** , 4-022 ^** , 4-023 ^** , 4-024 ^** , 4-025 ^** , 4-026 ^{* *} , 4-027 ^** , 4-028 ^** , 4-029 ^* , 4-030 ^* , 4-031 ^** , 4-032 ^** , 4-033
^* , 4-034,4-035 ^** , 4-036 ^** , 4-037 ^** , 4-038 ^** , 4-039 ^** , 4-040 ^** , 4-041 ^* , 4-042 〜4-045,4-046 ^** , 4-047,4-048,4-049 ^* , 4-050 ^* , 4-051 ^** , 4-052 ^** , 4-053 ^** , 4-054 ^** , 4-055 ^** , 4-056 ^** , 4-058,4-059,4-060 ^* , 4-061 ^* , 4-062 to 4-064,4-065 ^* , 4-066 ^* , 4-067,4-068 ^* , 4-069 ^* , 4-070 ^* , 4-071,4-072 ^* , 4-073,4-074 ^** , 4-075 ^* , 4-076,4- 077 ^* , 4-078,4-079 ^* , 4-080 ^* , 4-081 ^** , 4-082 ^* , 4-083 ^* , 4-084 ^* , 4-085 to 4-088,4-089 ^* , 4-090～4-095,4-096 ^**, 4-097 ^**, 4-098 ^*, 4-100,4-101 ^*, 4-102 ^*, 4-103 ^*, 4-104 ^** , 4-105 ^**, 4-106 ^**, 4-107 ^*, 4-108～4-112,4-113 ^**, 4-114 ^**, 4-115 ^**, 4-116～4- 119,4-120 ^**, 4-121 ^**, 4-122 ^**, 4-123 ^**, 4-124 ^**, 4-125 ^**, 4-126 ^**, 4-127 ^**, 4-128 ^** , 4-129 ^** , 4-130 ^* , 4-131 ^* , 4-132 ^* , 4-133 ^** , 4-134 ^** , 4-135 ^* , 4-136 ^** , 4-137 ^* , 4-138 ^* , 4-139 ^** , 4-140 ^** , 4-141 ^** , 4-142 ^** , 4-143 ^* , 4-144 ^* , 4-145 ^* , 4 -146 ^* , 4-147 ^* , 5-001 ^* , 5-002 ^* , 5-003 ^* , 5-004 ^** , 5-005 ^** , 5-006 ^* , 5-007 ^* , 5-008 ^{* *} , 5-009,5-011 ^** , 5-012 ^** , 5-013 ^** , 5-014 ^* , 5-015 ^* , 5-0 16 ^* , 5-017 ^* , 5-018 ^** , 5-019 ^* , 5-020 ^* , 5-021 ^* , 5-022,6-001 to 6-003,7-002,7-003 ^** , 7-004,7-005 ^* , 7-006,7-007 ^* , 7-008,7-009 ^** , 7-010 ^* , 7-011 ^* , 7-012 ^* , 7-013 ^** , 7-015 ^** , 7-017 ^** , 7-018,7-019,7-020 ^** , 7-021 ^** , 7-022 ^** , 7-023 ^** , 7-024 ^** , 7-025 ^** , 7-026 ^** , 7-027 ^** , 7-028 ^** , 7-029 ^** , 7-030 ^** , 7-031,7-034 ^* , 7-036 ^** , 7-037 ~ 7-039,7-040 ^** , 7-041 ^** , 7-042 ^** , 7-043 ^** , 7-044,7-045 ^* , 7-046 ^* , 7-047 , 7-048 ^** , 7-049 ^** , 7-050 ^** , 7-051 ^** , 7-052 ^** , 7-053 ^* , 7-054 ^** , 7-055 ^** , 7- 056 ^** , 7-057 ^** , 7-058 ^** , 7-059 ^* , 7-062 ^** , 7-063 ^** , 7-064 ^* , 7-065 ^** , 7-066 ^** , 7-067 ^** , 7-070 ^** , 7-071 ^** , 7-072 ^** , 7-073 ^** , 7-074 ^** , 7-075 ^** , 7-076 ^** , 7- 077 ^** , 7-080 ^** , 7-081 ^** , 7-082 ^* , 7-083 ^** , 7-084 ^** , 7-085 ^** , 7-086 ^** , 7-087 ^** , 7-088 ^* , 7-089 ^** , 7-090 ^** , 7-091 ^** , 7-092 ^** , 7-093 ^** , 7-094 ^* , 7-095 ^* 7-096 ^* , 7-097 ^* , 7-098 ^* , 7-099 ^* , 7-100,7-101 ^** , 7-102 ^** , 7-103 ^** , 7-104 ^* , 7-108 ^** , 7- 109 ^**, 7-110 ^**, 7-111 ^*, 7-112 ^**, 7-113 ^**, 7-114 ^**, 7-115 ^*, 7-116 ^** , 7-118 ^** , 7-119 ^** , 7-120 ^** , 7-121 ^** , 7-122 ^* , 7-123 ^** , 7-124 ^** , 7-125 ^** , 7- 126 ^**, 7-127,8-001～8-004,8-005 ^*, 8-006 ^*, 8-007～8-009,8-011 ^*, 8-012～8-014,8-015 ^* , 8-016,8-017 ^** , 8-018 ^** , 8-019 ^* , 8-020 ^* , 9-001,9-005,9-006,9-007 ^* , 9-008 to 9 -010,9-011 ^* , 9-012 ^** , 9-013 ^* , 9-014 to 9-018,9-019 ^* , 9-020,9-021,9-022 ^* , 9-023 ^* , 9-024 ^*, 9-025 ^*, 9-026～9-029,9-030 ^*, 9-031,9-032 ^*, 9-033 ^*, 9-034,9-035 ^*, 9-036 ^{* *} , 9-037 ^** , 9-038 ^* , 9-040,9-041,9-042 ^* , 9-043 ^* , 9-044 ^* , 9-047,9-048,9-049 ^* , 9 -050,9-051 ^* , 9-052 ^** , 9-055 ^* , 9-056 ^** , 9-057 ^* , 9-059 ^* , 9-060 ^* , 9-061,9-062 ^* , 9 -063 ^** , 9-065 ^* , 9-066 ^* , 9-067 ^** , 9-068 ^** , 9-069 ^* , 9-070,10-001,11-001,11-002,11- 005,11-008,11-011-11-015,11-018,11-019,11-020.

In addition, said ^* mark represents that the insecticidal test was implemented using the chemical solution of 100 ppm concentration, and ^** represents that the insecticidal test was implemented using the chemical solution of 10 ppm concentration.

Test Example 2 Insecticidal test against Spodoptera litura 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. Soak kanran leaves in this chemical solution for about 10 seconds, air-dry and place in a petri dish, in which 5 second-instar larvae of Spodoptera litura are released per petri dish, capped and placed in a thermostatic chamber at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No.1-001 ^* , 1-002 ^* , 1-003 ^* , 1-005 ^* , 1-006 ^* , 1-007 ^* , 1-008 ^* , 1-009 ^* , 1-010, 1-011,1-018,1-020 ^* , 1-021,1-023 ^* , 1-024 ^* , 1-026 ^* , 1-028 ^* , 1-029 ^* , 1-030 ^* , 1-032 ^* , 1-033 ~ 1-038,1-040,1-042 ~ 1-045,1-047 ~ 1-052,1-053 ^* , 1-054,1-056 ~ 1-058,1-060 , 1-061,1-062 ^* , 1-063 ^** , 1-064 ^** , 1-065 ^** , 1-066,1-067,1-068 ^** , 1-069 ^** , 1- 070,1-071,1-072 ^** , 1-073 ^** , 1-074 ^* , 1-075 ^** , 1-076,1-078,1-079 ^* , 1-080-1-085, 1-086 ^** , 1-087 to 1-090,1-091 ^* , 1-092,1-093 ^** , 1-094,1-095,1-096 ^** , 1-097,1-098 ^** , 1-099 to 1-103, 1-104 ^* , 1-105 to 1-107, 1-109 to 1-114, 1-116 ^* , 1-117, 1-118 ^** , 1-119 , 2-001 ^* , 2-002 ^* , 2-003,2-005 ^* , 2-006 ^* , 2-007 ^* , 2-009 ^* , 2-010 ^* , 2-011,2-012,2- 015,2-016 ^* , 2-017 ^* , 2-017 (a) ^* , 2-017 (d) ^** , 2-018 ^* , 2-019 ^* , 2-021 ^* , 2-022 ^* , 2 -024,2-025,2-026 ^** , 2-027 ^** , 2-028 ^** , 2-029 ^* , 2-030 ^* , 2-031 ^** , 2-032 ^* , 2-033 ^* , 2-034 ^** , 2-036 ^** , 2-037 ^* , 2-038 ^** , 2-039,2-040,2-041 ^** , 2-042 ^** , 2-043 ^* , 2 -044 ^* , 2-045 ^* , 2-046 ^* , 2-047 to 2-050,2-051 ^* , 2-052,2-0 53 ^* , 2-054 ^* , 2-055 ^* , 2-056,2-057 ^* , 2-058,2-059 ^** , 2-060 ^* , 2-061 ^** , 2-062 ^** , 2 -063 ^** , 2-064,2-065 ^* , 2-066 ^** , 2-067,2-068 ^** , 2-069 ^** , 2-070 ^** , 2-071,2-072 ^* , 2-073 ^** , 2-074, 2-077 ^* , 2-078 ^* , 2-079 ^** , 2-080 ^** , 2-081 ^** , 2-082 ^** , 2-083 ^** , 2-085 ^** , 2-086 ^* , 2-087 ^** , 2-089,2-091,2-092 ^** , 2-093 ^** , 2-095 ^** , 2-096 ^* , 2 -097 ^** , 2-098 ^* , 2-099 ^** , 2-100 ^** , 2-101,2-103 ^** , 2-104 ^** , 2-105 ^** , 2-106 ^** , 2-107 ^** , 2-108 ^** , 2-109 ^** , 2-110 ^** , 2-111 ^** , 2-112 ^** , 2-113 ^** , 2-114 ^** , 2- 115 ^** , 2-116 ^** , 2-117 ^** , 2-118 ^** , 2-119 ^** , 2-120 ^** , 2-121 ^** , 2-122 ^** , 2-124 ^{* *} , 2-125, 2-129 ^** , 2-130 ^** , 2-131 ^** , 2-132 ^** , 2-133 ^** , 2-134 ^** , 2-135 ^* , 2-136 , 2-137 ^**, 2-138 ^**, 2-139 ^**, 2-140 ^**, 2-141 ^**, 2-142 ^**, 2-143 ^**, 2-144 ^**, 2 -145 ^**, 2-146 ^**, 2-147 ^**, 2-148 ^**, 2-149 ^**, 2-150 ^**, 2-151 ^**, 2-152 ^**, 2-153 ^** , 2-154 ^** , 2-155 ^** , 2-156 ^* , 2-159 ^** , 2-160 ^** , 2-161 ^** , 2-163 ^** , 2-164 ^** , 2-165 ^** , 2-166 ^** , 2-167 ^** , 2-168 ^** , 2-169 ^* , 2-170 ^** , 2-171 ^** , 2-172 ^** , 2- 173 ^**, 2-174 ^**, 2-175 ^*, 2-176 ^**, 2-177 ^**, 2-178 ^**, 2-179 ^**, 2-180 ^**, 2-181 ^*, 2-182 ^** , 2-183 ^** , 2-184 ^** , 2-185 ^** , 2-186 ^* , 2-187 ^* , 2-190, 2-191, 2-192 ^** , 2- 193 ^**, 2-194 ^**, 2-195,2-196,2-197 ^**, 2-198,2-199 ^**, 2-200 ^**, 2-201 ^**, 2-202 ^* , 2-203 ^**, 2-204 ^*, 2-205 ^*, 2-206 ^*, 2-207 ^**, 2-208 ^*, 2-209 ^**, 2-210 ^*, 2-213,2- 215 ^** , 2-217 ^** , 2-218 ^** , 2-219 ^** , 2-220 ^* , 2-222 ^** , 2-223 ^** , 2-224 ^** , 2-225 ^** , 2-226 ^** , 2-227 ^** , 2-230 ^** , 2-231 ^** , 2-232 ^** , 2-233 ^* , 2-234 ^** , 2-235 ^** , 2- 236,2-238,2-240 ^*, 2-241,2-242 ^*, 2-243,2-244 ^*, 2-245 ^*, 2-246,2-247,2-248 ^**, 2- 249-2-252,2-253 ^** , 2-254 ^** , 2-255 ^* , 2-256,2-258 ^** , 2-259,2-261,2-262 ^** , 2-263 ^** , 2-265 ^** , 2-266 ^** , 2-267 ^* , 2-268 ^** , 2-269 ^* , 2-270 ^* , 2-271 ^** , 2-272 ^** , 2- 273 ^*, 2-274 ^**, 2-275 ^**, 2-276 ^**, 2-277 ^**, 2-278 ^*, 2-279 ^**, 2-280 ^**, 2-281 ^**, 2-282 ^** , 2-283 ^** , 2-284 ^** , 2-285 ^** , 2-286 ^* , 2-287 ^** , 2-288 ^** , 2-289 ^** , 2-290 ^**, 2-291,2-293 ^*, 2-295,2-296 ^*, 2-297,2-298,2-299 ^**, 2-300,2-301 ^*, 2-30 2,2-303,2-304 ^** , 2-305 ^** , 2-307 ^* , 2-308 ^* , 2-309 ^** , 2-310 ^** , 2-311 ^** , 2-312 ^* , 2-313 ^*, 2-314 ^**, 2-315 ^**, 2-316 ^**, 2-317 ^**, 2-318 ^**, 2-319 ^**, 2-320 ^**, 2- 321 ^**, 2-322 ^**, 2-323 ^**, 2-324 ^**, 2-325 ^**, 2-326 ^**, 2-327 ^**, 2-328 ^**, 2-329 ^{* *} , 2-330 ^** , 2-331 ^** , 2-332 ^* , 2-333 ^** , 2-334 ^** , 2-335 ^* , 2-336 ^* , 2-337 ^* , 2-338 ^* , 2-339 ^* , 2-340 ^* , 2-341 ^** , 2-342 ^* , 2-343 ^** , 2-344 ^** , 2-345 ^** , 2-346,2-347 ^* , 2 -348 ^* , 2-349 ^* , 2-350 ^** , 2-351 ^** , 2-352 ^** , 2-353 ^* , 2-354 ^* , 2-355 ^* , 2-356 ^** , 2- 357 ^* , 2-358 ^* , 2-359 ^** , 2-360 ^* , 2-361 ^** , 2-362 ^* , 2-363 ^* , 2-364 ^* , 2-365 ^** , 2-366 ^{* *,} 2-367 ^**, 2-368 ^**, 2-369 ^*, 2-370 ^*, 2-371 ^**, 2-372 ^*, 2-373 ^*, 2-374 ^**, 2-375 ^* , 2-376 ^* , 2-377 ^* , 2-378 ^** , 2-379 ^** , 2-380 ^** , 2-381 ^* , 2-382 ^** , 2-383 ^** , 2-384 ^* , 2-385 ^** , 2-386 ^* , 2-387 ^* , 2-388 ^* , 2-389 ^** , 2-390 ^** , 2-391 ^** , 2-392 ^** , 2-393 ^* , 2-394 ^*, 2-395 ^*, 2-396 ^**, 2-397 ^*, 2-398 ^*, 2-399 ^**, 2-400 ^**, 2-401 ^*, 2-402 ^*, 2 -403 ^* , 2-404 ^** , 2-405 ^** , 2-406 ^** , 2-407 ^** , 2-408 ^* , 2 -409 ^* , 2-410 ^** , 2-411 ^* , 2-412 ^* , 2-413 ^** , 2-414 ^* , 2-415 ^* , 2-416 ^* , 2-417 ^** , 2-418 ^** , 2-419 ^** , 2-420 ^** , 2-421 ^** , 2-422 ^* , 2-423 ^* , 2-424 ^** , 2-425 ^* , 2-426 ^** , 2- 427 ^** , 2-428 ^* , 2-429 ^* , 2-430 ^** , 2-431 ^** , 2-432 ^* , 2-433 ^** , 2-434 ^** , 2-435 ^** , 2 -436 ^* , 2-437 ^* , 2-438 ^** , 2-439 ^** , 2-440 ^** , 2-441 ^** , 2-442 ^** , 2-444 ^* , 2-446 ^** , 2-447 ^* , 2-448 ^* , 2-449 ^** , 2-450 ^** , 2-451 ^** , 2-452 ^** , 2-454 ^* , 2-455 ^* , 2-456 ^* , 2 -457 ^** , 2-458 ^** , 2-459 ^** , 2-460 ^** , 2-461 ^* , 2-462 ^* , 2-463 ^** , 2-464 ^* , 2-465 ^** , 2-466 ^* , 2-467 ^* , 2-468 ^* , 2-469 ^** , 2-470 ^** , 2-471 ^* , 2-472 ^* , 2-473 ^* , 2-474 ^** , 2- 475 ^** , 2-476 ^** , 2-477 ^* , 2-478 ^** , 2-479 ^** , 2-480 ^** , 2-481 ^* , 2-482 ^** , 2-483 ^* , 2 -484 ^** , 2-485 ^* , 2-486,2-487 ^* , 2-488 ^** , 2-489 ^** , 2-490 ^** , 2-491 ^* , 2-492 ^** , 2- 493 ^** , 2-494 ^* , 2-495 ^* , 2-496 ^** , 2-497 ^* , 2-498 ^* , 2-499 ^** , 2-500 ^** , 2-501 ^** , 2- 502 ^** , 2-503 ^** , 2-504 ^** , 2-505 ^* , 2-506 ^* , 2-507 to 2-509,2-510 ^* , 2-511 ^* , 2-512 ^** , 2-513,2-514 ^* , 2-515 ^** , 2-516 ^** , 2-517 ^** , 2-518 ^* , 2-519 ^* , 2-521 ^* , 2-522 ^* , 2-523 ^* , 2-524 ^* , 2-525 ^** , 2-526 ^* , 2-527 ^* , 2-528 ^** , 2-531 ^** , 2-532 ^** , 2-533,2-534 ^* , 2-535 ^* , 2-536 ^** , 3-001 ^* , 3-002,3-003 ^* , 3-004 ^** , 3 -005 ^* , 3-006 ^* , 3-007 ^** , 3-008 ^** , 3-009 ^* , 3-010 ^** , 3-011 ^** , 3-012 ^* , 3-013 ^* , 3- 014 ^*, 3-015 ^*, 4-001 ^*, 4-002 ^*, 4-003 ^*, 4-004 ^**, 4-005 ^**, 4-006 ^*, 4-007 ^*, 4-008 ^*, 4-009 ^* , 4-010 ^* , 4-011 ^* , 4-012 ^** , 4-013 ^** , 4-014 ^* , 4-015 ^** , 4-016 ^** , 4-017 ^** , 4-018 ^** , 4-019 ^** , 4-020 ^** , 4-021 ^** , 4-022 ^** , 4-023 ^** , 4-024 ^** , 4-025 ^** , 4- 026 ^**, 4-027 ^**, 4-028 ^**, 4-029 ^*, 4-030 ^*, 4-033 ^*, 4-034,4-035 ^**, 4-
036 ^** , 4-037 ^** , 4-038 ^** , 4-039 ^** , 4-040 ^** , 4-041 ^* , 4-042 to 4-045,4-046 ^** , 4-047 , 4-048,4-049 ^* , 4-050 ^* , 4-051 ^** , 4-052 ^** , 4-053 ^** , 4-054 ^** , 4-055 ^** , 4-056 ^** , 4-058,4-059,4-060 ^* , 4-062,4-064,4-065 ^* , 4-066 ^* , 4-067,4-069 ^* , 4-071,4-072 ^* , 4-074 ^** , 4-076,4-077 ^* , 4-078,4-079 ^* , 4-080 ^* , 4-082 ^* , 4-083 ^* , 4-086,4-088,4-089 ^* , 4-090,4-091,4-095,4-096 ^** , 4-097 ^** , 4-098 ^* , 4-100,4-101 ^* , 4-102 ^* , 4-103 ^* , 4-105 ^** , 4-106 ^** , 4-107 ^* , 4-109 to 4-112,4-114 ^** , 4-115 ^** , 4-116 to 4-119,4-120 ^** , 4-121 ^**, 4-122 ^**, 4-123 ^**, 4-124 ^**, 4-125 ^**, 4-126 ^**, 4-127 ^**, 4-128 ^**, 4 -129 ^** , 4-130 ^* , 4-131 ^* , 4-132 ^* , 4-133 ^** , 4-134 ^** , 4-135 ^* , 4-136 ^** , 4-137 ^* , 4- 138 ^* , 4-139 ^** , 4-140 ^** , 4-141 ^** , 4-142 ^** , 4-143 ^* , 4-144 ^* , 4-145 ^* , 4-146 ^* , 4-147 ^* , 5-001 ^* , 5-003 ^* , 5-004 ^** , 5-005 ^** , 5-006 ^* , 5-007 ^* , 5-008 ^** , 5-011 ^** , 5-014 ^* , 5-015 ^* , 5-016 ^* , 5-017 ^* , 5-018 ^** , 5-019 ^* , 5-020 ^* , 5-022,6-001,7-003 ^** , 7-004, 7-005 ^* , 7-006,7-007 ^* , 7-008,7-009 ^** , 7-010 ^* , 7-011 ^* , 7-012 ^* , 7-013 ^** , 7-014 ^* , 7-015 ^** , 7-017 ^** , 7-019,7-020 ^** , 7-021 ^** , 7-022 ^** , 7-023 ^{* *} , 7-024 ^** , 7-025 ^** , 7-026 ^** , 7-028 ^** , 7-029 ^** , 7-030 ^** , 7-031,7-032,7-034 ^* , 7-036 ^** , 7-037 ~ 7-039,7-040 ^** , 7-041 ^** , 7-042 ^** , 7-043 ^** , 7-045 ^* , 7-046 ^* , 7 -047,7-048 ^** , 7-049 ^** , 7-050 ^** , 7-051 ^** , 7-052 ^** , 7-053 ^* , 7-054 ^** , 7-055 ^** , 7-056 ^** , 7-057 ^** , 7-058 ^** , 7-059 ^* , 7-060 ^* , 7-061 ^* , 7-062 ^** , 7-063 ^** , 7-064 ^* , 7-065 ^** , 7-066 ^** , 7-067 ^** , 7-068 ^* , 7-069 ^* , 7-070 ^** , 7-071 ^** , 7-072 ^** , 7-073 ^{* *} , 7-074 ^** , 7-075 ^** , 7-076 ^** , 7-077 ^** , 7-078 ^* , 7-079 ^* , 7-080 ^** , 7-081 ^** , 7- 082 ^* , 7-083 ^** , 7-084 ^** , 7-085 ^** , 7-086 ^** , 7-087 ^** , 7-088 ^* , 7-089 ^** , 7-090 ^** , 7-091 ^** , 7-092 ^** , 7-093 ^** , 7-094 ^* , 7-095, 7-096 ^* , 7-097 ^* , 7-098 ^* , 7-099 ^* , 7-100 , 7-101 ^** , 7-102 ^** , 7-103 ^** , 7-104 ^* , 7-105 ^* , 7-106 ^* , 7-108 ^** , 7-109 ^** , 7-110 ^{* *} , 7-111 ^* , 7-112 ^** , 7-113 ^** , 7-114 ^** , 7-115 ^* , 7-116 ^** , 7-117 ^** , 7-118 ^** , 7- 119 ^** , 7-120 ^** , 7-121 ^** , 7-122 ^* , 7-123 ^** , 7-124 ^** , 7-125 ^** , 7-127 , 8-002,8-005 ^* , 8-006 ^* , 8-007,8-014,8-015 ^* , 8-018 ^** , 8-020 ^* , 9-007 ^* , 9-010,9- 011 ^* , 9-013 ^* , 9-014 to 9-018,9-019 ^* , 9-020,9-022 ^* , 9-023 ^* , 9-024 ^* , 9-025 ^* , 9-026,9 -027,9-030 ^* , 9-031,9-032 ^* , 9-033 ^* , 9-034,9-037 ^** , 9-038 ^* , 9-040,9-041,9-042 ^* , 9-044 ^* , 9-045 ^* , 9-046 ^** , 9-048,9-049 ^* , 9-050,9-051 ^* , 9-055 ^* , 9-057 ^* , 9-060 ^* , 9 -061,9-062 ^*, 9-064 ^*, 9-065 ^*, 9-066 ^*, 9-069 ^*, 11-001,11-011,11-012,11-015.

In addition, said ^* mark represents that the insecticidal test was implemented using the chemical solution of 100 ppm concentration, and ^** represents that the insecticidal test was implemented using the chemical solution of 10 ppm concentration.

Test Example 3 Insecticidal test against Syringoptera: A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 100 ppm. Immerse kanran leaves in this solution for about 10 seconds, air dry and place in a petri dish. In this, 5 second-instar larvae of Spodoptera exigua are released per petri dish, capped and placed in a constant temperature room at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No. 2-031, 2-032, 2-035, 2-036, 2-044, 2-105, 2-106, 2-111, 2-140, 2-143, 2-144, 2-147, 2-148, 2-151, 2-177, 2-178, 2-258, 2-311, 2-315, 2-331, 2-388, 2-434, 2-478, 2- 536,4-004,4-008,4-027,4-074,4-105,4-114,4-122,5-005,7-022,7-024,7-028,7-049, 7-052,7-058,7-062,7-063,7-071,7-072,7-074,7-077,7-086,7-087,7-089,7-101〜7- 103,7-108,7-109,7-112,7-121,7-125.

Test Example 4 Insecticidal Test for Chahamaki A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder was tested) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 100 ppm. Immerse kanran leaves in this solution for about 10 seconds, air dry and place in a petri dish. In this, 5 second-instar larvae of Homona magnanima are released per petri dish, covered and placed in a constant temperature room at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No.2-017 (d), 2-028,2-029,2-031,2-032,2-034,2-044,2-051,2-054,2-057,2 -059,2-061,2-062,2-069,2-070,2-073,2-079 to 2-082,2-095,2-097,2-100,2-104 to 2-107 , 2-110, 2-111, 2-118 to 2-122, 2-124, 2-129, 2-130, 2-134, 2-137, 2-138, 2-140, 2-143-2 -148, 2-150, 2-151, 2-153, 2-164 to 2-168, 2-171, 2-172, 2-176 to 2-179, 2-182 to 2-185, 2-192 〜 2-194, 2-197, 2-203, 2-217, 2-218, 2-222, 2-231, 2-232, 2-234, 2-266, 2-283, 2-284, 2 -315,2-316,2-320,2-321,2-324,2-327 to 2-331,2-333,2-345,2-348,2-350 to 2-353,2-360 , 2-362,2-364 to 2-366,2-368,2-369,2-371,2-372,2-376,2-378,2-381,2-384,2-386,2 -388,2-390,2-392,2-394,2-401,2-402,2-404,2-406 to 2-408,2-410,2-411,2-415,2-419 , 2-420, 2-423 to 2-428, 2-430, 2-433 to 2-435, 2-437, 2-439, 2-447, 2-454, 2-455, 2-457, 2 -458,2-460,2-461,2-471,2-473,2-476 to 2-478,2-482,2-488,2-494,2-496 to 2-498,2-521 , 2-531,2-532,2-534,2-536,3-008,4-012,4-013,4-015,4-016,4-018,4-023,4-024,4 -027,4-028,4-030,4-036,4-039,4-052,4-053,4-055,4-074,4-081,4-104,4-105,4-114 , 4-123 to 4-131, 4-133 to 4-138, 4-141, 4-142, 5-005, 7-036, 7 -059,7-085,9-022.

Test Example 5 Insecticidal test against giant tobacco moth 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder was tested) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 100 ppm. Immerse kanran leaves in this solution for about 10 seconds, air dry and place in a petri dish. Release 2 second-instar larvae of Helicoverpa armigera per petri dish, cover and place in a constant temperature room at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. Note that the test was conducted in a 12-unit system.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No.1-001 to 1-003,1-005,1-008 to 1-010,1-015,1-020,1-022,1-026,1-029,1-031, 1-032,1-043,1-053,1-061〜1-070,1-072〜1-076,1-078〜1-080,1-082〜1-104,1-118,2- 002, 2-005 to 2-007, 2-009, 2-016, 2-017, 2-017 (d), 2-018, 2-019, 2-021, 2-024 to 2-038, 2 -040,2-042 to 2-054,2-057,2-059,2-061 to 2-063,2-065,2-069,2-070,2-072 to 2-074,2-076 〜2-083,2-085〜2-088,2-092,2-093,2-095,2-097〜2-100,2-103,2-104,2-106〜2-122,2 -124, 2-125, 2-129 to 2-134, 2-137 to 2-156, 2-159 to 2-161, 2-163 to 2-174, 2-176 to 2-180, 2-182 〜2-187,2-190〜2-194,2-197,2-199〜2-210,2-217〜2-225,2-227,2-228,2-230〜2-234,2 -240, 2-244, 2-247 to 2-250, 2-252 to 2-255, 2-258, 2-262 to 2-290, 2-293, 2-294, 2-296, 2-298 , 2-299, 2-301 to 2-305, 2-307 to 2-339, 2-341 to 2-345, 2-347 to 2-366, 2-368 to 2-444, 2-446 to 2 -452, 2-454 to 2-502, 2-504, 2-506, 2-510, 2-511, 2-514 to 2-519, 2-521 to 2-529, 2-531 to 2-536 , 3-001,3-004 to 3-013,3-015,4-001,4-002,4-004,4-005,4-007 to 4-010,4-012 to 4-044,4 -046 to 4-057, 4-059 to 4-062, 4-064, 4-066, 4-068 to 4-075, 4-077 to 4-079, 4-081 to 4-084 , 4-086, 4-088 to 4-092, 4-096 to 4-098, 4-100 to 4-115, 4-118 to 4-147, 5-001 to 5-008, 5-010 to 5 -020,5-022,6-001,7-003 to 7-005,7-007,7-009,7-012 to 7-014,7-017,7-020 to 7-032,7-034 , 7-036,7-038,7-040-7-043,7-045,7-048-7-094,7-096-7-098,7-101-7-106,7-108-7 -126,8-002,8-016 to 8-018,8-020,9-001 to 9-004,9-011 to 9-013,9-015,9-017 to 9-019,9-022 , 9-023,9-025,9-026,9-028,9-030,9-032,9-033,9-035,9-037 ~ 9-040,9-042 ~ 9-045,9 -051,9-052,9-064.

Test Example 6 Insecticidal test against citrus white thrips Place a wet filter paper on a styrene cup with an inner diameter of 7 cm, place a bean leaf cut to the same diameter on it, and place 1 instar larvae of citrus thrips (Frankliniella occidentalis) per leaf Ten animals were inoculated. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 2 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No.1-001 to 1-003, 1-005 to 1-009, 1-034 to 1-038, 1-040, 1-042, 1-043, 1-048, 1-049 1-052 to 1-054, 1-057, 1-060 to 1-073, 1-075 to 1-106, 1-113, 1-114, 1-116, 1-118, 2-001 to 2- 003,2-005 to 2-009,2-011,2-016,2-017,2-017 (a), 2-017 (d), 2-018,2-019,2-021,2- 022,2-024,2-026 to 2-038,2-041 to 2-055,2-057 to 2-059,2-061,2-062,2-066,2-068 to 2-070, 2-072, 2-073, 2-076, 2-078 to 2-083, 2-085 to 2-089, 2-092, 2-093, 2-095 to 2-100, 2-103 to 2- 120, 2-122, 2-124, 2-126 to 2-134, 2-138 to 2-141, 2-143 to 2-145, 2-147, 2-148, 2-150 to 2-154, 2-158, 2-161, 2-163 to 2-168, 2-171, 2-176 to 2-179, 2-181 to 2-187, 2-192 to 2-195, 2-197, 2- 198,2-200,2-202 to 2-204,2-210,2-211,2-213,2-215 to 2-217,2-222 to 2-224,2-226,2-229 to 2-232, 2-238, 2-239, 2-246, 2-249, 2-254, 2-258, 2-267, 2-269, 2-279, 2-282, 2-284, 2- 287,2-293,2-296,2-299,2-301,2-303,2-304,2-308,2-313 to 2-315,2-317 to 2-320,2-322, 2-323,2-326,2-327,2-330,2-331,2-342,2-343,2-346 to 2-353,2-356 to 2-360,2-362 to 2- 366, 2-368, 2-369, 2-371, 2-372, 2-374 to 2-379, 2-381 to 2-384, 2-386 to 2-390, 2-392, 2-394, 2-396〜2-399,2- 401-2-408, 2-410, 2-411, 2-413-2-418, 2-420-2-425, 2-427, 2-428, 2-430, 2-431, 2-433, 2-436 to 2-441, 2-446 to 2-448, 2-450, 2-452, 2-454 to 2-461, 2-463, 2-465 to 2-469, 2-471 to 2- 474, 2-476 to 2-480, 2-482 to 2-485, 2-487 to 2-491, 2-494 to 2-500, 2-520, 2-521, 2-525, 2-527, 2-529,2-535,2-536,3-004,3-005,3-007,3-008,3-010,3-012,3-013,4-002,4-004 to 4- 018,4-021,4-023,4-025,4-027,4-028,4-030,4-034,4-037,4-039,4-047,4-052,4-055, 4-056,4-071,4-074,4-077,4-078,4-080 to 4-083,4-086,4-088,4-098,4-104,4-106,4- 107,4-109,4-111,4-120,4-124,4-127,4-130 to 4-139,4-141 to 4-147,5-001,5-003,5-005, 5-008,5-009,5-014,5-018,7-002 to 7-006,7-008,7-009,7-011 to 7-013,7-017,7-019 to 7- 021,7-023-7-026,7-029-7-033,7-036-7-039,7-042,7-043,7-048-7-052,7-059,7-062- 7-067,7-070〜7-075,7-077,7-080〜7-083,7-086〜7-091,7-094,7-095,7-097,7-098,7- 101,7-102,7-104,7-108〜7-119,7-121,7-122,8-006,8-015,8-017,8-018,9-007,9-011〜 9-015,9-017,9-018,9-022-9-027,9-040,9-041,9-043,9-057,9-061,9-063,9-070,10- 001,11-002.

Test Example 7 Insecticidal test against southern blue thrips Place a wet filter paper on a 7 cm inner diameter styrol cup, place green beans cut to the same diameter on it, and place 10 thrips palmi adults per leaf Vaccinated. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 100 ppm. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 2 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No.1-001 to 1-003,1-005,1-006,1-008,1-043,1-049,1-053,1-057,1-060,1-062 1-073,1-075,1-076,1-078〜1-082,1-084〜1-097,1-100〜1-103,1-118,2-002,2-005〜2- 007,2-009,2-016,2-017,2-017 (a), 2-017 (d), 2-018,2-019,2-021,2-022,2-027 ~ 2- 035,2-037,2-041 ~ 2-054,2-057,2-059,2-062,2-066,2-068 ~ 2-070,2-072,2-073,2-079 ~ 2-083, 2-085, 2-087, 2-092, 2-095 to 2-100, 2-103 to 2-122, 2-124, 2-126 to 2-134, 2-137 to 2- 156, 2-158 to 2-161, 2-163 to 2-174, 2-176 to 2-187, 2-192 to 2-194, 2-197 to 2-208, 2-215 to 2-220, 2-222 to 2-227, 2-230 to 2-235, 2-239, 2-240, 2-246 to 2-249, 2-253, 2-254, 2-258, 2-262, 2- 263, 2-265 to 2-275, 2-278 to 2-290, 2-293, 2-296, 2-299, 2-303 to 2-305, 2-307 to 2-331, 2-333, 2-334, 2-337, 2-338, 2-342 to 2-345, 2-347 to 2-366, 2-368 to 2-441, 2-446 to 2-448, 2-450 to 2- 452, 2-454 to 2-485, 2-487 to 2-490, 2-492 to 2-494, 2-496 to 2-501, 2-510 to 2-512, 2-516, 2-518, 2-520 to 2-528,2-531,2-532,2-534 to 2-536,3-004 to 3-012,4-001 to 4-004,4-007 to 4-009,4- 011 ~ 4-034,4-036 ~ 4-044,4-046,4-049 ~ 4-053,4-055 ~ 4-057,4-061,4-062,4-065 ~ 4-069,4-071,4-072,4-074,4-078〜4-083,4-088,4-091,4-096〜4-098,4-104〜4-107,4- 109 ~ 4-111, 4-113 ~ 4-115, 4-117, 4-120 ~ 4-139, 4-141 ~ 4-145, 5-001 ~ 5-005, 5-007 ~ 5-009, 5-011,5-012,5-014〜5-019,5-021,5-022,7-003〜7-005,7-008,7-009,7-011〜7-013,7- 015,7-017-7-032,7-034,7-036,7-040-7-043,7-045,7-046,7-048-7-052,7-055,7-057 ~ 7-083,7-086-7-091,7-094-7-097,7-101-7-127,8-006,8-015,8-017,8-018,8-020,9- 007, 9-010 to 9-013, 9-018 to 9-027, 9-030 to 9-033, 9-037 to 9-044, 9-046, 9-047, 9-052, 9-064.

Test Example 8 Insecticidal test against white-spotted beetle A 10% emulsion of the present compound (10% wettable powder depending on the compound) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. . Immerse rice leaf sheath in this solution for about 10 seconds, air-dry it, put it in a test tube. And housed in a constant temperature room at 25 ° C. The number of dead insects after 2 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No.1-001 to 1-003,1-006 to 1-009,1-020,1-053,1-054,1-062 to 1-065,1-069,1-072, 1-075,1-079,1-086,1-091,1-093,1-096,1-104,2-002,2-003,2-005,2-006,2-008 ~ 2- 013, 2-016, 2-017, 2-017 (d), 2-018, 2-019, 2-021 to 2-023, 2-027 to 2-034, 2-041, 2-043 to 2 -046,2-051,2-053 to 2-055,2-057,2-059,2-061,2-062,2-066,2-068 to 2-070,2-073,2-079 ~ 2-083,2-085,2-087,2-092,2-095 ~ 2-098,2-100,2-105,2-106,2-111,2-115,2-117,2 -119, 2-120, 2-134, 2-140, 2-144, 2-148, 2-151, 2-167, 2-178, 2-181 to 2-187, 2-192, 2-193 , 2-197, 2-220, 2-226, 2-267, 2-284, 2-290, 2-301, 3-003, 3-004, 3-008, 4-001, 4-002, 4 -005,4-008 to 4-010,4-012,4-013,4-015,4-016,4-018,4-021,4-028,4-039,4-080,4-098 4-104,5-005,7-003,7-009,7-013,8-005,8-006,8-020,9-016,9-019,9-020,11-001.

Test Example 9 Insecticidal test against green planthopper A 10% emulsion of the compound of the present invention (10% wettable powder depending on the compound) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. The leaf sheath of rice is immersed in this chemical for about 10 seconds, air-dried and placed in a test tube. Five second-instar larvae of Nilaparvata lugens are released per test tube, covered with a sponge and sealed. Housed in a constant temperature room. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No.1-001,1-002,1-034,1-042 to 1-044,1-046,1-062 to 1-064,1-066,1-067,1-069, 1-070, 1-075, 1-078, 1-079, 1-081, 1-082, 1-084, 1-086 to 1-089, 1-091 to 1-093, 1-095 to 1- 097,2-005,2-010,2-016,2-018,2-028,2-029,2-031 to 2-033,2-035,2-039,2-044 to 2-046, 2-048, 2-049, 2-051, 2-054, 2-055, 2-059, 2-061, 2-066, 2-068 to 2-070, 2-073, 2-079 to 2- 083,2-085,2-087,2-092,2-095,2-096,2-098,2-100,2-103,2-105,2-106,2-107 ^* , 2-108 ^* , 2-109 ^* , 2-111, 2-112 ^* , 2-113 ^* , 2-119 to 2-122, 2-124, 2-126, 2-129 ^* , 2-130 ^* , 2-131 , 2-134,2-138,2-140,2-144,2-145 ^*, 2-148,2-149 ^*, 2-151,2-163 ^*, 2-162 ^*, 2-165 ^*, 2-167, 2-171 ^* , 2-176, 2-178, 2-181 to 2-184, 2-197, 2-202, 2-203, 2-208, 2-215 to 2-217, 2 -219 to 2-222, 2-224 ^* , 2-225 ^* , 2-231 ^* , 2-232 ^* , 2-239, 2-284, 2-290, 2-304, 2-316 ^* , 2- 321 ^*, 2-324 ^*, 2-328 ^*, 2-329 ^*, 2-333,2-341,2-342,2-345 ^*, 2-348,2-349,2-350 ^*, 2 351 ^* , 2-353,2-361 ^* , 2-362,2-364,2-365 ^* , 2-366 ^* , 2-367 ^* , 2-371 ^* , 2-376,2-385,2- 386,2-388,2-389,2-390 ^* , 2-397,2-423,2-424 ^* , 2-425,2-428,2-430 ^* , 2-436,2-437,2 -439,2-440 ^* , 2-441 ^* , 2-457 ^* , 2-459 ^* , 2-463 ^* , 2-473,2-526 ^* , 3-004,3-007,3-008,3-010,3-011 , 4-011 ~ 4-013,4-015,4-016,4-017 ^* , 4-018,4-019 ^* , 4-021,4-023,4-025 ^* , 4-028,4- 030,4-034,4-039,4-052,4-055 ^* , 4-056,4-074 ^* , 4-078,4-082,4-098,4-104,4-105 ^* , 4 -113,4-120,4-123 ^*, 4-131,4-132,4-134 ^*, 4-135,4-136 ^*, 4-138,5-001,5-005,7-003～ 7-005,7-008,7-009,7-011-7-013,7-017,7-020,7-021,7-022 ^* , 7-023 ^* , 7-024 ^* , 7-025 , 7-026 ^* , 7-028 ^* , 7-029,7-030 ^* , 7-036,7-038,7-039,7-042,7-059,7-063 ^* , 7-064,7 -074 ^* , 7-083 ^* , 7-085 ^* , 7-087 ^* , 7-088,7-090 ^* , 7-092 ^* , 7-094,7-104,7-111,7-114 ^* , 7-115,8-006,8-020,9-014,9-020,11-009.

In addition, said ^* mark represents having implemented the insecticidal test using the chemical | medical solution with a 100 ppm density | concentration.

Test Example 10 Insecticidal test for silver leaf whitefly A tomato leaf (10 eggs / leaf) laid on silver leaf whitefly (Bemisia argentifolii) was cut and placed on a 7 cm inner diameter styrol cup. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No.1-001,1-002,1-006 to 1-008,1-035,1-036,1-038,1-042,1-043,1-053,1-054, 1-060, 1-062 to 1-067, 1-069 to 1-072, 1-075 to 1-086, 1-089 to 1-093, 1-095, 1-096, 1-099 to 1- 103,1-118,2-003,2-005,2-006,2-008,2-009,2-012,2-016,2-017,2-017 (d), 2-018,2 -019,2-021,2-024,2-026,2-029 ~ 2-034,2-036,2-037,2-043 ~ 2-051,2-055,2-057,2-059 , 2-061, 2-062, 2-064, 2-066, 2-068 to 2-070, 2-073, 2-078 to 2-083, 2-087, 2-092, 2-093, 2 -095,2-096,2-098,2-100,2-105,2-106,2-111,2-112,2-115,2-119 to 2-122,2-129,2-134 , 2-140, 2-144, 2-145, 2-147, 2-148, 2-151, 2-152, 2-161, 2-164, 2-176, 2-178, 2-179, 2 -181 to 2-186, 2-190, 2-192, 2-193, 2-200, 2-208, 2-216, 2-222, 2-226, 2-239, 2-249, 2-254 , 2-267, 2-279, 2-282, 2-284, 2-286, 2-287, 2-290, 2-293, 2-294, 2-304, 2-308, 2-313, 2 -314,2-316,2-321,2-324,2-326,2-328,2-329,2-342,2-345,2-348〜2-353,2-359〜2-366 , 2-368, 2-369, 2-371, 2-372, 2-375 to 2-377, 2-379, 2-384 to 2-386, 2-388 to 2-390, 2-392, 2 -397 to 2-399, 2-401 to 2-404, 2-406, 2-407, 2-410, 2-414 to 2-417, 2-420, 2-421, 2-423 to 2-425 , 2-427, 2-436 to 2-441, 2-454 to 2-461, 2-466 to 2 -477,2-479,2-480,2-487 to 2-489,2-494,2-496 to 2-498,2-500,2-521,2-527,2-534 to 2-536 , 3-004,3-005,3-007,3-008,3-011,3-012,4-011,4-012,4-016,4-018,4-020,4-021,4 -023,4-027,4-028,4-034,4-044,4-078,4-080,4-132,4-133,4-138,4-141,5-005,5-014 , 7-003,7-013,7-017,7-019,7-020,7-036,7-037,7-077,7-088,7-115,8-006,9-018,9 -022,9-024,9-031,9-069.

Test Example 11 Insecticidal test against peach aphid A moist absorbent cotton is laid on a glass petri dish with an inner diameter of 3 cm, and kanran leaves cut into the same diameter are placed on it. did. One day later, a 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm. The chemical solution was sprayed (2.5 mg / cm ² ), covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No.1-001, 1-042 to 1-044, 1-046, 1-047, 1-062 to 1-064, 1-066, 1-067, 1-069, 1-070, 1-072, 1-076 to 1-082, 1-084 to 1-087, 1-092 to 1-097, 1-099 to 1-101, 1-103, 1-105, 1-106, 1- 113,1-118,2-010,2-017,2-021,2-026,2-029 ~ 2-033,2-037,2-039,2-043,2-044,2-046 ~ 2-052,2-054,2-056,2-057,2-059,2-061,2-062,2-066,2-068,2-073,2-076,2-077,2- 079 to 2-083, 2-085, 2-087, 2-092, 2-093, 2-095, 2-098, 2-100, 2-103, 2-105, 2-106, 2-107 ^* , 2-111, 2-115, 2-119 ^* , 2-120, 2-121, 2-124, 2-129 ^* , 2-130 ^* , 2-131, 2-134 ^* , 2-140, 2 -144,2-147,2-148,2-153 ^* , 2-157,2-167,2-181 to 2-184,2-186,2-187,2-192,2-195,2- 197,2-203,2-220,2-224 ^*, 2-225 ^*, 2-256,2-259,2-267,2-282,2-284,2-286 ^*, 2-290,2 -304,2-313,2-316 ^*, 2-321 ^*, 2-324 ^*, 2-328 ^*, 2-329 ^*, 2-342,2-345 ^*, 2-348,2-349,2 -350 ^* , 2-352 ^* , 2-353,2-358,2-359 ^* , 2-361 ^* , 2-362 to 2-364,2-365 ^* , 2-366 ^* , 2-367 ^* , 2-368 ^* , 2-369,2-371 ^* , 2-372,2-374 ^* , 2-375 to 2-377,2-378 ^* , 2-379 ^* , 2-384,2-385 ^* , 2-386～2-388,2-389 ^*, 2-390 ^*, 2-391 ^*, 2-397,2-398,2-399 ^*, 2-401～2-403,2-404 ^*, 2 -406 ^* , 2-407 ^* , 2-410 ^* , 2-414,2-416,2-419 ^* , 2-420 ^* , 2-423,2-424 ^* , 2-425,2-428,2-430 ^* , 2-435 ^* , 2-436 to 2-439,2-440 ^* , 2-441 ^* , 2-456,2-457 ^* , 2-458 ^* , 2-459 ^* , 2-460 ^* , 2-461 , 2-463 ^* , 2-466,2-468,2-470 ^* , 2-471,2-473,2-474 ^* , 2-476 ^* , 2-477,2-479 ^* , 2-480 ^* , 2-488 ^* , 2-490 ^* , 2-494,2-521,2-525 ^* , 2-526 ^* , 2-534,2-536 ^* , 3-004,3-008,4-009, 4-012,4-013,4-020 ^* , 4-021,4-023,4-028,4-030,4-059,4-080,4-082,4-088,4-098,4 -111,4-113,4-120,4-123 ^* , 4-131,4-132,4-134 ^* , 4-135,4-137,4-138,4-139 ^* , 4-141 ^* , 4-142 ^* , 5-001,5-005,5-008,5-014,7-003,7-004,7-011-7-013,7-017,7-020,7-021, 7-025,7-030 ^* , 7-036-7-038,7-059,7-063 ^* , 7-064,7-070 ^* , 7-071 ^* , 7-074 ^* , 7-076 ^* , 7-080 ^* , 7-081 ^* , 7-082,7-083 ^* , 7-085 ^* , 7-086 ^* , 7-087 ^* , 7-088,7-089 ^* , 7-090 ^* , 7- 092 ^* , 7-093 ^* , 7-094,7-098 to 7-100,7-104,7-109 ^* , 7-111,7-112 ^* , 7-113 ^* , 7-115,7-118 ^* , 8-006.

In addition, said ^* mark represents having implemented the insecticidal test using the chemical | medical solution with a 100 ppm density | concentration.

Test Example 12 Insecticidal test against Aphididae Place a moist filter paper on a 7cm inner diameter styrene cup, place a bean leaf cut to the same diameter on it, and place 1-year-old larvae of Planococcus kraunhiae per leaf. Ten animals were inoculated. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No.1-002,1-007,1-035,1-042,1-043,1-049,1-052,1-062 to 1-064,1-077,1-079 1-081,1-084〜1-087,1-091,1-092,1-095,1-096,1-100,1-101,1-103,2-004,2-006,2- 008, 2-009, 2-016, 2-017 (d), 2-021, 2-027, 2-030, 2-032 to 2-034, 2-036, 2-043 to 2-047, 2 -049,2-050,2-057,2-059,2-061,2-062,2-066,2-068 to 2-070,2-073,2-079 to 2-083,2-087 , 2-088, 2-092, 2-093, 2-095 to 2-098, 2-105, 2-106, 2-111, 2-120, 2-134, 2-140, 2-144, 2 -148, 2-151, 2-167, 2-181, 2-183, 2-185, 2-186, 2-190, 2-193, 2-257, 2-259, 2-267, 2-284 , 2-303,2-308,2-313,3-004,3-008,4-002,4-004,4-007,4-008,4-012,4-013,4-018,4 -021,4-043,4-080,4-098,5-005,5-014,7-003,7-013,7-014,7-017,8-006,8-015,9-010 , 9-024,9-031.

Test Example 13 Insecticidal test against cucumber potato beetle A 10% emulsion of the compound of the present invention (10% wettable powder was tested depending on the compound) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. Soak cucumber leaves in this chemical for about 10 seconds, air dry and place in a petri dish. In this, 5 second-instar larvae of Aulacophora femoralis are released per petri dish, covered and kept in a constant temperature room at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No.1-001 to 1-011,1-017,1-020 to 1-224,1-026,1-028 to 1-038,1-041 to 1-055,1-057, 1-059 to 1-119, 2-001 to 2-013, 2-016, 2-017, 2-017 (a), 2-017 (d), 2-018, 2-019, 2-021, 2-022, 2-024 to 2-090, 2-092 to 2-102, 2-105, 2-106, 2-111, 2-115, 2-117, 2-119, 2-120, 2- 134, 2-136, 2-140, 2-144, 2-148, 2-151, 2-157, 2-167, 2-169, 2-178, 2-181 to 2-197, 2-210 to 2-214, 2-220, 2-226, 2-236, 2-239 to 2-241, 2-256, 2-259, 2-261, 2-267, 2-269, 2-278, 2- 284,2-290,2-293,2-301,2-303,2-308,2-312,2-313,3-001 to 3-005,3-008,4-001 to 4-016, 4-018,4-021,4-028,4-030,4-039,4-041,4-043,4-052,4-080,4-088,4-098,4-099,4- 104,5-005,5-008,5-014,5-015,6-001,7-001,7-003 to 7-015,7-017,7-018,8-002 to 8-007, 8-009,8-011-8-020,9-006-9-008,9-010-9-027,9-030,9-031,9-046,10-001.

Test Example 14 Insecticidal test against legume fly A 10% emulsion of the compound of the present invention (10% wettable powder depending on the compound) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. In this chemical solution, a 7 cm diameter kidney bean leaf (10 eggs / leaf) spawned in Liriomyza trifolii was immersed for about 10 seconds, air-dried, and then wetted filter paper laid on a 7 cm inner diameter styrol cup. It was placed on top, covered and housed in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No.1-001,1-002,1-006 to 1-008,1-032,1-042,1-043,1-049,1-053,1-054,1-062 1-067,1-069〜1-071,1-075,1-076,1-078〜1-081,1-083,1-086,1-088,1-089,1-095,1- 096,1-101,1-104,2-003,2-005 to 2-007,2-009,2-016,2-017,2-017 (d), 2-018,2-019,2 -021, 2-027 to 2-035, 2-037, 2-042 to 2-054, 2-057 to 2-059, 2-061, 2-062, 2-066, 2-068 to 2-070 , 2-073,2-079 ~ 2-083,2-085,2-087,2-090,2-092,2-093,2-095 ~ 2-097,2-100,2-105,2 -106, 2-111, 2-122, 2-144, 2-178, 2-182, 2-184, 2-185, 2-222, 2-284, 2-324, 2-348 to 2-353 , 2-362,2-364 to 2-366,2-368,2-369,2-372,2-375 to 2-377,2-386,2-388,2-389,2-402,2 -404,2-423,2-425,2-436 to 2-440,2-457,2-471,2-473,2-474,2-476,2-479,2-488,2-489 , 2-494,2-496,2-498,2-500,2-521,3-004,4-002,4-005,4-007,4-009,4-011,4-012,4 -027, 4-141, 5-005, 5-008, 8-006.

Test Example 15 Insecticidal test against a spider mite A moist filter paper was laid on a styrene cup having an inner diameter of 7 cm, and a green kidney leaf cut out to the same diameter was placed thereon, and 10 larvae of the spider mite (Tetranychus urticae) were inoculated per leaf. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No.1-001 to 1-003,1-006,1-007,1-042,1-053,1-054,1-062 to 1-066,1-069 to 1-071, 1-075 to 1-086, 1-088 to 1-090, 1-092 to 1-096, 1-100 to 1-104, 1-116, 1-118, 2-002, 2-003, 2- 005 to 2-012, 2-016, 2-017, 2-017 (d), 2-018, 2-019, 2-021, 2-022, 2-024, 2-026 to 2-037, 2 -043 to 2-055, 2-057, 2-059, 2-061 to 2-063, 2-066, 2-068 to 2-070, 2-073, 2-076 to 2-083, 2-085 , 2-087,2-090,2-092,2-093,2-095 to 2-100,2-103,2-104 ^** , 2-105,2-106,2-107 ^* , 2- 108 ^* , 2-109 ^** , 2-111, 2-112 ^* , 2-113 ^* , 2-114 ^** , 2-115, 2-116 ^* , 2-117 ^* , 2-118 ^* , 2- 119 ^* , 2-120 to 2-122, 2-124, 2-126 to 2-128, 2-129 ^* , 2-130 ^* , 2-131, 2-132 ^* , 2-133 ^** , 2- 134 ^* , 2-137 ^* , 2-138, 2-139 ^** , 2-140, 2-141 ^* , 2-142 ^** , 2-143 ^** , 2-144, 2-145 ^** , 2 -146 ^* , 2-147,2-148,2-149 ^** , 2-151,2-152 ^** , 2-153 ^* , 2-154 ^** , 2-158,2-163 ^** , 2 -164 ^* , 2-165 ^** , 2-166 ^* , 2-167,2-168 ^* , 2-169,2-171 ^** , 2-173 ^** , 2-174 ^* , 2-175 ^* , 2-176,2-177 ^**, 2-178,2-179 ^**, 2-180 ^*, 2-181～2-187,2-190～2-198,2-199 ^*, 2-200～ 2-205,2-206 ^*, 2-207,2-208,2-209 ^*, 2-210～2-212,2-214～2-217,2-218 ^* , 2-219 to 2-222,2-223 ^* , 2-224 ^* , 2-225 ^* , 2-226 to 2-228, 2-231 ^** , 2-232 ^** , 2-233 ^* , 2 -234 ^** , 2-235 ^** , 2-236,2-2238,2-2239,2-2241,2-245 ^* , 2-246,2-248 ^* , 2-249,2-250,2 -253 ^* , 2-254,2-255,2-258,2-259,2-261,2-262 ^* , 2-263 ^** , 2-265,2-267,2-268 ^* , 2- 274 ^**, 2-275 ^**, 2-278,2-279,2-281 ^**, 2-282～2-284,2-286 ^*, 2-287 ^*, 2-290,2-296, 2-298,2-299,2-301,2-304,2-305 ^* , 2-307 ^** , 2-308,2-309 ^* , 2-310 ^** , 2-311 ^** , 2- 313,2-316 ^** , 2-324 ^** , 2-325 ^** , 2-329 ^** , 2-333,2-341,2-342,2-343 ^** , 2-347 ~ 2- 349,2-350 ^* , 2-351 ^* , 2-352 ^* , 2-353,2-357,2-358,2-359 ^* , 2-360,2-361 ^* , 2-362 to 2-364 , 2-365 ^* , 2-366 ^** , 2-368 ^* , 2-369,2-371 ^** , 2-372,2-375 to 2-377,2-378 ^* , 2-379 ^* , 2 -381 ^* , 2-383 ^* , 2-384,2-385 ^* , 2-386 to 2-388,2-389 ^* , 2-390 ^** , 2-391 ^** , 2-392 ^* , 2- 394,2-397,2-398,2-399 ^* , 2-401 to 2-403,2-404 ^* , 2-405 ^* , 2-406 ^** , 2-407 ^* , 2-408,2- 410 ^**, 2-411,2-414～2-416,2-417 ^*, 2-420 ^*, 2-422,2-423,2-424 ^*, 2-425,2-427 ^*, 2 428,2-430 ^** , 2-433 ^* , 2-436 to 2-439,2-440 ^* , 2-441 ^** , 2-447,2-454 to 2-456,2-457 ^* , 2-458 ^* , 2-459 ^** , 2-460 ^* , 2-461,2-463 ^** , 2-466 to 2-468,2-469 ^* , 2-470 ^* , 2-471 to 2 -473,2-474 ^* , 2-475 ^** , 2-476 ^** , 2-477,2-478 ^* , 2-479 ^* , 2-480 ^* , 2-482 ^** , 2-483,2 -484 ^* , 2-485,2-487,2-488 ^* , 2-489 ^* , 2-490 ^* , 2-493 ^* , 2-494,2-495,2-496 ^* , 2-497,2 -498,2-500 ^* , 2-507 to 2-509,2-511,2-513,2-520,2-521,2-524 ^* , 2-525 ^* , 2-526 ^* , 2-527 , 2-531 ^* , 2-534,2-535,2-536 ^* , 3-004,3-007,3-008,3-010 to 3-012,4-001,4-003,4-005 , 4-008,4-009,4-012 to 4-016,4-017 ^** , 4-018,4-019 ^* , 4-020 ^* , 4-021,4-022 ^** , 4-023 , 4-024 ^* , 4-025 ^** , 4-026 ^* , 4-027 ^* , 4-028,4-029 ^* , 4-030,4-031,4-033 ^* , 4-034,4- 035,4-036 ^* , 4-037 ^** , 4-038 ^* , 4-039,4-040 ^* , 4-041,4-043,4-044,4-047,4-050 ^* , 4- 051 ^* , 4-053 ^* , 4-054 ^* , 4-055 ^** , 4-056,4-057 ^* , 4-058,4-059,4-066 to 4-072,4-074 ^* , 4 -076～4-078,4-079 ^*, 4-080,4-081 ^*, 4-082,4-083,4-090,4-098,4-101 ^*, 4-102 ^*, 4-103 ^* , 4-104, 4-105 ^* , 4-106 ^* , 4-107 ^* , 4-109 to 4-111, 4-113, 4-114 ^* , 4-115 ^** , 4-117, 4- 120,4-125 ^*, 4-127 ^*, 4-130～4-132,4-133 ^*, 4-134 ^**, 4-135,4-136 ^**, 4-137,4-138 , 4-139 ^* , 4-141 ^* , 4-142 ^** , 4-143,4-144,4-146,4-147,5-001,5-003 to 5-005,5-007,5 -008,5-011 ^* , 5-014,5-017 ^* , 5-018,5-019 ^* , 5-020,5-021,7-012,7-017,7-019 ~ 7-021, 7-036-7-038,7-042,7-044,7-045,7-059,7-063 ^* , 7-064,7-074 ^* , 7-111,7-115,8-006, 8-015 ~ 8-017,8-020,9-013,9-069 ^* .

In addition, said ^* mark represents that the insecticidal test was implemented using the chemical solution of 100 ppm concentration, and ^** represents that the insecticidal test was implemented using the chemical solution of 10 ppm concentration.

Test Example 16 Insecticidal test against citrus mite mite Put a moist filter paper on a 7 cm inner diameter styrol cup, place citrus leaves cut out on the same diameter, and inoculate 10 larvae of citrus mite (Aculops pelekassi) per leaf . A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 100 ppm. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No.2-017, 2-021, 2-031, 2-032, 2-034 to 2-036, 2-051, 2-059, 2-069, 2-079 to 2-082, 2-095, 2-104 to 2-106, 2-110, 2-111, 2-115, 2-124, 2-129, 2-133, 2-139, 2-140, 2-143-2 145, 2-147, 2-148, 2-150, 2-151, 2-153, 2-154, 2-164, 2-165, 2-167, 2-168, 2-171, 2-177 ... 2-179, 2-182 to 2-184, 2-194, 2-207, 2-222, 2-225, 2-231, 2-232, 2-248, 2-274, 2-275, 2- 279,2-285,2-289,2-304,2-309,2-311,2-314 to 2-317,2-319,2-320,2-322,2-324 to 2-327, 2-330,2-331,2-343,2-344,2-362,2-371,2-384,2-386,2-388,2-402,2-419,2-431,2- 434,2-435,2-447,2-478,3-007,4-004,4-008,4-023,4-025,4-027,4-037,4-056,4-074, 4-081,4-097,4-105,4-120,4-121,4-124,4-128,5-005,7-022,7-024,7-028,7-030,7- 036,7-042,7-048,7-049,7-052,7-058,7-063,7-071,7-074,7-077,7-087,7-109,7-112, 7-125.

Test Example 17 Insecticidal test against chrysanthemum mites Laminated filter paper was placed on a 7 cm inner diameter styrol cup, and green beans cut out to the same diameter were placed thereon, and 10 adults of polyphagotarsonemus latus were inoculated per leaf. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 100 ppm. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 2 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No. 2-031, 2-036, 2-069, 2-079 to 2-082, 2-104, 2-106, 2-110, 2-122, 2-124, 2-133, 2-139, 2-140, 2-143, 2-184, 2-258, 2-279, 2-316, 2-325, 2-384, 2-388, 2-439, 2-470, 2- 478,2-531,4-114,4-121,4-124,4-128,7-022,7-024,7-028,7-049,7-051,7-052,7-062, 7-063,7-071,7-074,7-077,7-087,7-102,7-109,7-121,7-125.

Test Example 18 Insecticidal test for cat flea Catonyl flea (Cat flea) test was conducted by applying 400 μl of an acetone solution in which 4 mg of the compound of the present invention was dissolved in 40 ml of acetone (100 ppm concentration) to the bottom and sides of a petri dish having an inner diameter of 5.3 cm. Thus, a thin film of the compound of the present invention was formed on the petri dish inner wall. Since the inner wall of the petri dish used is 40 cm ² , the amount of treatment treatment is 0.1 μg / cm ² . Ten adult cat fleas (Ctenocephalides felis) (mixed male and female) were released, covered, and housed in a constant temperature room at 25 ° C. The number of dead insects after 4 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. Note that the test was conducted in a single run.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No.2-031,2-032,2-361,2-367,2-385,2-391,2-426,2-431,2-439,2-470,7-063, 7-067,7-071,7-072,7-074,7-077,7-080,7-086,7-087,7-091,7-101,7-102,7-108,7- 109,7-112.

Test Example 19 Insecticidal test against tick (American dog tick) After applying 400 μl of an acetone solution in which 4 mg of the compound of the present invention was dissolved in 40 ml of acetone (100 ppm concentration) on two petri dishes with an inner diameter of 5.3 cm, Acetone was volatilized to form a thin film of the compound of the present invention on the petri dish inner wall. Since the inner wall of the petri dish used is 40 cm ² , the amount of treatment treatment is 0.1 μg / cm ² . Ten American dog tick (Dermacentor variabilis) first nymphs (mixed male and female) were released, and two were combined. The joints were taped to prevent escape and housed in a thermostatic chamber at 25 ° C. The number of dead insects after 4 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. Note that the test was conducted in a single run.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No.2-021,2-031,2-032,2-143,2-361,2-367,2-372,2-378,2-380,2-383,2-385, 2-391,2-394,2-418,2-426,2-439,2-446,2-450,2-452,2-470,2-475,2-478,2-482,2- 484,2-493,2-498,2-501,2-502,2-504,2-510,2-525 to 2-528,2-531,2-532,4-137,4-143, 7-063,7-065〜7-067,7-070〜7-077,7-080,7-081,7-087,7-091,7-102,7-109,7-116,7- 117,7-119,7-120,7-126.

  The substituted isoxazoline compound according to the present invention exhibits excellent pest control activity, particularly insecticidal / miticidal activity, and is extremely useful with little adverse effect on non-target organisms such as mammals, fish and beneficial insects. A compound.

Claims (14)

General formula (1):

[Wherein, A ¹ , A ² , A ³ and A ⁴ each independently represent CY or N;
G represents a benzene ring, a nitrogen-containing 6-membered aromatic heterocycle, a furan ring, a thiophene ring or a 5-membered aromatic heterocycle containing two or more heteroatoms selected from an oxygen atom, a sulfur atom and a nitrogen atom;
L is -C (R ⁴ ) (R ^4a )-, -C (R ⁴ ) (R ^4a ) CH _2- , -CH ₂ C (R ⁴ ) (R ^4a )-, -N (R ^4b )- Or -C (R ⁴ ) (R ^4a ) N (R ^4b )-
X is a halogen atom, cyano, nitro, _{azido, -SCN, -SF 5, C 1} ~C 6 alkyl, optionally substituted by R ⁵ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl , optionally substituted by R ⁵ (C ₃ ~C ₈₎ cycloalkyl, optionally substituted by _{E-1~E-50, C 2} ~C 6 _{^{alkenyl, R 5 (C 2 ~C 6}} ) alkenyl , C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₂ -C ₆ alkynyl, optionally substituted by R ⁵ (C ₂ ^~C ₆₎ alkynyl, -OH, -OR ^6, - OS (O) ₂ R ⁶ , -SH, -S (O) _r R ⁶ , -N (R ⁸ ) R ⁷ , -N = C (R ^8a ) R ^7a , -C (O) R ⁹ , -C (R ⁹ ) = NOH, -C (R ⁹ ) = NOR ¹⁰ , M-5, M-20, M-48, -C (O) OR ¹⁰ , -C (O) SR ¹⁰ , -C (O) N (R ¹² ) R ¹¹ , -C (S) OR ¹⁰ , -C (S) SR ¹⁰ , -C (S) N (R ¹² ) R ¹¹ , M-40 to M-43, M-46, M -47, -S (O) ₂ OR ¹⁰ , -S (O) ₂ N (R ¹² ) R ¹¹ , -Si (R ^13a ) (R ^13b ) R ¹³ , phenyl, phenyl substituted by (Z) _p1 Or D-1 to D-65 And, when m represents an integer of 2 or more, each X may be the or different from each other the same as each other,
Further, when two Xs are adjacent to each other, the two adjacent Xs are -CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ O-, -CH ₂ OCH _2- , -OCH ₂ O-, -CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -CH ₂ CH ₂ N (R ¹⁴ )-, -CH ₂ N (R ¹⁴ ) CH _2- , -CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH _2- , -CH ₂ OCH ₂ O-, -OCH ₂ CH ₂ O-, -OCH ₂ CH ₂ S-, -CH ₂ CH = CH-,- OCH = CH-, -SCH = CH-, -N (R ¹⁴ ) CH = CH-, -OCH = N-, -SCH = N-, -N (R ¹⁴ ) CH = N-, -N (R ¹⁴ By forming N = CH-, -CH = CHCH = CH-, -OCH ₂ CH = CH-, -N = CHCH = CH-, -N = CHCH = N- or -N = CHN = CH- A 5-membered ring or a 6-membered ring may be formed together with the carbon atom to which each of two Xs is bonded. At this time, the hydrogen atom bonded to each carbon atom forming the ring is optionally substituted by Z. In addition, when simultaneously substituted with two or more Z, each Z may be the same as or different from each other,
Y is a hydrogen atom, a halogen atom, cyano, nitro, _{azido, -SCN, -SF 5, C 1} ~C 6 alkyl, optionally substituted by R ⁵ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally substituted by R ⁵ (C ₃ ~C ₈₎ cycloalkyl, E-1~E-50, C 2 ~C 6 alkinyl, optionally substituted by R ⁵ (C ₂ ~C ₆₎ ^{alkynyl, -OH, -OR 6, -OS (} O) 2 R 6, -SH, -S (O) r R 6, -N (R 8) R 7, -N (R 8) C (O ) R ^9a , -N = C (R ^8a ) R ^7a , -C (O) N (R ¹² ) R ¹¹ , -C (S) N (R ¹² ) R ¹¹ , -Si (R ^13a ) (R ^13b ) R ¹³ , phenyl, (Z) phenyl substituted by _p1 or D-1 to D-65, and when two or more Y are present at the same time, each Y may be the same as or different from each other You may,
Further, when two Ys are adjacent to each other, the two adjacent Ys are —CH ₂ CH ₂ CH ₂ —, —CH ₂ CH ₂ O—, —CH ₂ OCH ₂ —, —OCH ₂ O—, —CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -SCH ₂ S-, -CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH ₂ -,- CH ₂ OCH ₂ O-, -OCH ₂ CH ₂ O-, -OCH ₂ CH ₂ S-, -SCH ₂ CH ₂ S-, -OCH = N-, -SCH = N-, -CH = CHCH = CH- , -CH = CHCH = N-, -CH = CHN = CH-, -CH = NCH = CH- or -N = CHCH = CH- to form 5 together with the carbon atom to which each of the two Y bonds. A hydrogen atom bonded to each carbon atom forming the ring may be optionally substituted by Z, and at the same time two or more Z may be formed. When substituted, each Z may be the same as or different from each other,
R ¹ is a hydrogen atom, -C (O) R ^1a , -C (O) OR ^1b , -C (O) SR ^1b , -C (O) N (R ^1d ) R ^1c , -C (S) R ^1a , -C (S) OR ^1b , -C (S) SR ^1b , -C (S) N (R ^1d ) R ^1c , -S (O) ₂ R ^1b or -S (O) ₂ N (R ^1d ) ^Represents R ^1c
R ^1a is hydrogen atom, C ₁ -C ₁₂ alkyl, optionally substituted by R ¹⁵ (C ₁ ~C ₁₂₎ alkyl, C ₃ -C ₁₂ cycloalkyl, optionally substituted by R ¹⁵ (C ₃ -C ₁₂₎ cycloalkyl, E-1~E-50, C 2 ~C 12 alkenyl, optionally substituted by R ¹⁵ (C ₂ ~C ₁₂₎ alkenyl, C ₅ -C ₁₂ cycloalkenyl, C ₅ ~ C ₁₂ halo cycloalkenyl, C ₂ -C ₁₂ alkynyl, optionally substituted by R ¹⁵ (C ₂ ~C ₁₂₎ ^{alkynyl, - [C (R 16a)} (R 16b)] n -R 16, -C ( O) R ⁹ , -C (O) R ^9a , -C (R ⁹ ) = NOH, -C (R ⁹ ) = NOR ¹⁰ , -C (R ⁹ ) = NN (R ¹² ) R ¹¹ , -C ( O) OR ¹⁰ , -C (O) N (R ¹² ) R ¹¹ , phenyl, (Z) phenyl substituted by _p1 or D-1 to D-65,
R ^1b is optionally substituted by C ₁ -C ₁₂ alkyl, optionally substituted by R ¹⁵ (C ₁ ~C ₁₂₎ alkyl, C ₃ -C ₁₂ cycloalkyl, R ¹⁵ (C ₃ ~C ₁₂ ) Cycloalkyl, E-3, E-4, E-6, E-8, E-10, E-25, E-26, E-28, E-29, E-31, E-32, E- 35, E-38, E- 42, E-46, E-49, C 2 ~C 12 alkenyl, C ₂ -C ₁₂ haloalkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, phenyl, (Z) phenyl substituted by _p1 , D-1 to D-4, D-6 to D-13, D-15 to D-23, D-25 to D-37, D-39, D-40, D-42, D-43, D-45, D-47 or D-50 to D-65,
R ^1c is a hydrogen atom, C ₁ -C ₁₂ alkyl, optionally substituted by R ¹⁵ (C ₁ ~C ₁₂₎ alkyl, C ₃ -C ₁₂ cycloalkyl, optionally substituted by R ¹⁵ (C ₃ -C ₁₂₎ cycloalkyl, E-3~E-6, E -8, E-10, E-24~E-26, E-28, E-29, E-31, E-32, E-35 , E-38, E-42 , E-46, E-49, C 2 ~C 12 alkenyl, C ₂ -C ₁₂ haloalkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, - [C (R ^16a ) (R ^16b )] _n -R ¹⁶ , -C (O) R ⁹ , -C (O) R ^9a , -C (R ⁹ ) = NOR ¹⁰ , -C (O) OR ¹⁰ , -C (O) SR ¹⁰ , -C (O) N (R ¹² ) R ¹¹ , M-11, M-28, -C (S) R ⁹ , -C (S) OR ¹⁰ , -C (S) SR ¹⁰ , -C (S) N (R ¹² ) R ¹¹ , M-14, M-32, -OR ¹⁰ , -S (O) ₂ R ¹⁰ , -S (O) ₂ N (R ¹² ) R ¹¹ ,- N (R ¹⁸ ) R ¹⁷ , phenyl, phenyl substituted by (Z) _p1 , D-1 to D-45 or D-47 to D-65,
R ^1d is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₆₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl Or R ^1d together with R ^1c forms a C ₂ -C ₆ alkylene chain, thereby forming a 3- to 7-membered ring with the nitrogen atom to which R ^1c and R ^1d are bonded. represents good, this time the alkylene chain an oxygen atom, may contain one sulfur atom or a nitrogen atom, and C ₁ -C ₆ alkyl group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, C ₁ -C ₆ alkylaminocarbonyl group, C ₁ -C ₆ halo alkylaminocarbonyl group, di (C ₁ -C ₆ alkyl) amino Carbonyl group may optionally be substituted by oxo group or thioxo group,
R ² is hydrogen atom, cyano, C ₁ -C ₁₂ alkyl, (C ₁ -C ₁₂ ) alkyl, C ₃ -C ₁₂ cycloalkyl, C ₃ -C ₁₂ alkenyl, C ₃ optionally substituted by R ^15a -C ₁₂ haloalkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ ^{haloalkynyl, -C (O) R 9,} -C (O) R 9a, -C (O) OR 10, -C (O) SR ¹⁰ , -C (O) N (R ¹² ) R ¹¹ , -C (O) C (O) OR ¹⁰ , -C (S) OR ¹⁰ , -C (S) SR ¹⁰ , -C (S) N (R ¹² ) R ¹¹ , C ₁ -C ₁₂ alkoxy, C ₁ -C ₁₂ haloalkoxy, -SR ¹⁰ , -S (O) ₂ R ¹⁰ , -SN (R ^18a ) R ^17a , phenyl, (Z) _p1 R ¹ and R ² are linked by representing phenyl substituted by D or D-52 to D-54, or R ² together with R ¹ to form a C _{4 to} C ₆ alkylene chain together with the nitrogen atom represent that may form a 5- to 7-membered ring, this time the alkylene chain an oxygen atom, may contain one sulfur atom or a nitrogen atom, and C ₁ -C ₆ alkyl group, C ₁ C ₆ alkylidene group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ haloalkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, C ₁ -C ₆ haloalkoxycarbonyl groups, C ₁ -C ₆ alkylaminocarbonyl group, C ₁ -C ₆ halo alkylaminocarbonyl group, di (C ₁ -C ₆ alkyl) aminocarbonyl group, a phenyl group, D-52 group, D-55 group, optionally by an oxo group or thioxo group May be replaced,
R ³ represents a halogen atom, cyano, optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ⁵ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ⁵ ( C ₃ -C ₈₎ cycloalkyl, E-1~E-50, C 3 ~C 6 alkenyl, optionally substituted by R ⁵ (C ₂ ~C ₆₎ alkenyl, C ₃ -C ₆ alkynyl, R ⁵ (C ₂ -C ₆ ) alkynyl, -OR ⁶ , -S (O) _r R ⁶ , -N (R ¹² ) R ¹¹ , -C (O) R ⁹ , -C (R ⁹ ) = NOH, -C (R ⁹ ) = NOR ¹⁰ , M-5, M-20, M-48, -C (O) OR ¹⁰ , -C (O) SR ¹⁰ , -C (O) N (R ^{12) R 11, -C (S} ) OR 10, -C (S) SR 10, -C (S) N (R 12) R 11, -Si (R 13a) (R 13b) R 13, -P ( O) (OR ¹⁹ ) ₂ , phenyl, (Z) phenyl substituted by _p1 or D-1 to D-65,
R ⁴ is a hydrogen atom, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, C ₁ -C _{6 alkoxycarbonyl, -C (O) NH 2,} -C (S) NH 2, phenyl, (Z) phenyl substituted by _{p1, D-1~D-4,} D-18, D-21 or D-52 ~ Represents D-54,
R ^4a represents a hydrogen atom or C ₁ -C ₆ alkyl, or R ^4a together with R ⁴ forms a C ₂ -C ₅ alkylene chain, thereby binding R ⁴ and R ^4a It indicates that may form a 3-6 membered ring with the carbon atom, this time the alkylene chain an oxygen atom, may contain one sulfur atom or a nitrogen atom, and C ₁ -C ₄ alkyl group, -CHO group, C ₁ -C ₄ alkylcarbonyl group, C ₁ -C ₄ alkoxycarbonyl group, C ₁ -C ₄ alkylaminocarbonyl group, C ₁ -C ₄ halo alkylaminocarbonyl group, di (C ₁ -C ₄ alkyl) amino Optionally substituted by a carbonyl group or a phenyl group,
R ^4b is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₃ -C ₆ cycloalkylcarbonyl, C ₃ -C ₆ halocycloalkyl carbonyl, represents C ₁ -C ₆ alkoxycarbonyl or C ₁ -C ₆ haloalkoxycarbonyl,
D-1 to D-65 each represent an aromatic heterocycle represented by the following structural formula;

Z is a halogen atom, cyano, nitro, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkoxy (C ₁ ~ C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, -OH, C ₁ ~C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ haloalkyl sulfonyloxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ Haroaruki Sulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, -NH _2, C ₁ ~C ₆ alkyl amino, di (C ₁ -C ₆ alkyl) amino, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C _{6 haloalkoxycarbonyl, -C (O) NH 2,} C 1 ~C 6 alkyl amino carbonyl, C ₁ -C ₆ haloalkylcarbonyl aminocarbonyl, di (C ₁ -C ₆ alkyl) aminocarbonyl, -C (S ) NH ₂ , —S (O) ₂ NH ₂ , C ₁ -C ₆ alkylaminosulfonyl, di (C ₁ -C ₆ alkyl) aminosulfonyl or phenyl, p1, p2, p3 or p4 is an integer of 2 or more Each Z may be the same as or different from each other;
Further, when two Zs are adjacent to each other, the two adjacent Zs are -CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ O-, -CH ₂ OCH _2- , -OCH ₂ O-, -CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -CH ₂ CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH _2- , -CH ₂ OCH ₂ O- , -OCH ₂ CH ₂ O-, -CH ₂ CH ₂ CH ₂ S-, -OCH ₂ CH ₂ S- or -CH = CH-CH = CH- may form a 5- or 6-membered ring together with the carbon atom, this time, the hydrogen atoms bonded to each carbon atom forming the ring is a halogen atom, a cyano group, a nitro group, C ₁ -C ₄ alkyl group may be optionally substituted by C ₁ -C ₄ haloalkyl groups, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio group,
E-1 to E-50 each represent a saturated heterocyclic ring represented by the following structural formula,

R ⁵ is a halogen atom, cyano, C _{3 to} C ₈ cycloalkyl, C _{3 to} C ₈ halocycloalkyl, E-1 to E-50, —OH, —OR ⁶ , —SH, —S (O) _r R ⁶ , -N (R ⁸ ) R ⁷ , -N (R ⁸ ) C (O) R ^9a , -C (O) OR ¹⁰ , -C (O) N (R ¹² ) R ¹¹ , -Si (R ^13a ) (R ^13b ) R ¹³ , phenyl, (Z) phenyl substituted by _p1 or D-1 to D-65,
R ⁶ is optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ²² (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ²² (C ₃ ~C ₈ ) Cycloalkyl, E-3 to E-6, E-8, E-10, E-24 to E-26, E-28, E-29, E-31, E-32, E-35, E- 46, C ₂ -C ₆ alkenyl, optionally substituted by R ²² (C ₂ ~C ₆₎ alkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl, optionally substituted by R ²² (C ₃ ~C ₆₎ alkynyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, phenyl, phenyl substituted by (Z) _p1, D-1~D -4, D-6 to D-13, D-15 to D-23, D-25 to D-37, D-39, D-40, D-42, D-43, D-45, D-47 Or D-50 to D-65,
R ⁷ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ ^{haloalkynyl, -C (O) R 9,} -C (O) OR 10, -C (O) SR ^{10, -C (O) N (} R 12) R 11, -C (S) OR 10, -C (S) SR 10, -C (S) N (R 12) R 11, -C (O) C (O) R ¹⁰ , -C (O) C (O) OR ¹⁰ , -OH, -S (O) ₂ R ¹⁰ , -S (O) ₂ N (R ¹² ) R ¹¹ , -P (O) ( OR ¹⁹ ) ₂ or -P (S) (OR ¹⁹ ) ₂
R ⁸ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, -CHO, C ₁ -C ₆ alkylcarbonyl, or represents C ₁ -C ₆ haloalkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl, or , R ⁸ together with R ⁷ represents a C _{2 to} C ₆ alkylene chain, thereby forming a 3- to 7-membered ring with the nitrogen atom to which R ⁷ and R ⁸ are bonded; in this case the alkylene chain is an oxygen atom, may contain one sulfur atom or a nitrogen atom, and optionally substituted halogen atom, C ₁ -C ₄ alkyl group, C ₁ -C ₄ haloalkyl group, the oxo group or thioxo group May have been
R ^7a represents C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₃ -C ₆ alkenyloxy, phenoxy or phenoxy substituted by (Z) _p1 ;
R ^8a represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ alkenyl, phenyl or phenyl substituted by (Z) _{p 1} , or R ^8a is R ^7a Together with C ₄ -C ₆ alkylene chain to form a 5- to 7-membered ring together with the carbon atoms to which R ^7a and R ^8a are attached, wherein the alkylene chain is May contain one oxygen or sulfur atom,
R ⁹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E- 5~E-10, E-24~E- 32, C 2 ~C 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₂ -C ₆ alkynyl or C ₂ -C ₆ haloalkynyl,
R ^9a represents phenyl, phenyl substituted by (Z) _p1 , naphthyl or D-1 to D-65;
R ¹⁰ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E-3 -E -6, E-8, E-10, E-24 to E-26, E-28, E-29, E-31, E-32, E-35, E-38, E-42, E-46 _{, E-49, C 2 ~C} 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ halo Alkynyl, phenyl, phenyl substituted by (Z) _p1 , D-1 to D-4, D-6 to D-13, D-15 to D-23, D-25 to D-37, D-39, D-40, D-42, D-43, D-45, D-47 or D-50 to D-65,
R ¹¹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E- 3 to E-6, E-8, E-10, E-24 to E-26, E-28, E-29, E-31, E-32, E-35, E-38, E-42, E-46, E-49, C 2 ~C 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, phenyl, phenyl substituted by (Z) _p1, D-1 to D-45 or D-47 to D-65
R ¹² is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₄₎ alkyl, or represents C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl, or, R ¹² is R ^{11 represents} a C _{2 to} C ₆ alkylene chain to form a 3- to 7-membered ring together with the nitrogen atom to which R ¹¹ and R ¹² are bonded. oxygen atom may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₄ alkyl group, C ₁ -C ₄ alkoxy group, -CHO group, C ₁ -C ₄ alkylcarbonyl group or a C It may be optionally substituted by ₁ -C ₄ alkoxycarbonyl group,
R ¹³ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, phenyl or phenyl substituted by (Z) _p1 ;
R ^13a and R ^13b each independently represent C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₆ alkoxy;
R ¹⁴ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ haloalkoxycarbonyl (C ₁ -C ₄₎ alkyl, phenyl (C ₁ -C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ -C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ ~ C ₆ represents alkynyl, C ₃ -C ₆ haloalkynyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, phenyl substituted by phenyl or (Z) _p1,
Further, when Z is present at the adjacent position to R ¹⁴ is, -CH ₂ and adjacent R ¹⁴ and _{Z CH 2 CH 2 CH 2 -} , -CH = CH-CH = CH-, -N = CH- An atom to which each of R ¹⁴ and Z is bonded by forming CH = CH-, -CH = N-CH = CH-, -CH = CH-N = CH- or -CH = CH-CH = N- may form a 6-membered ring with a substituted this time, a hydrogen atom is a halogen atom attached to each carbon atom forming the ring, optionally by C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl group May have been
R ¹⁵ is a halogen atom, cyano, nitro, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, hydroxy (C ₃ -C ₈ ) cycloalkyl, C ₁ -C ₄ alkoxy (C ₃ -C ₈₎ cycloalkyl, E-1~E-50, C 5 ~C 10 cycloalkyl, C ₅ -C ₁₀ halo ^{cycloalkenyl, -OR 23, -N (R 24} ) R 23, -C (O) R 26 , -C (R ²⁶ ) = NOH, -C (R ²⁶ ) = NOR ²⁷ , -C (O) OH, -C (O) OR ²⁷ , -C (O) SR ²⁷ , -C (O) N ( R ²⁹ ) R ²⁸ , -C (O) N (R ²⁹ ) OR ²⁷ , -C (O) N (R ²⁹ ) N (R ^28a ) R ²⁸ , -C (O) C (O) OR ²⁷ ,- C (S) OR ²⁷ , -C (S) SR ²⁷ , -C (S) N (R ²⁹ ) R ²⁸ , -C (= NR ²⁸ ) OR ²⁷ , -C (= NR ²⁸ ) SR ²⁷ , -C (= NR ²⁹ ) N (R ^28a ) R ²⁸ , -C (= NOR ²⁷ ) N (R ²⁹ ) R ²⁸ , -S (O) ₂ OH, -S (O) ₂ OR ²⁷ , -S (O) ₂ N (R ²⁹ ) R ²⁸ , -Si (R ^13a ) (R ^13b ) R ¹³ , -P (O) (OR ¹⁹ ) ₂ , -P (S) (OR ¹⁹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , M-1 to M-48, phenyl, phenyl substituted by (Z) _p1 , naphthyl or D-1 to D-65,
R ^15a is a halogen atom, cyano, nitro, C _{3 to} C ₈ cycloalkyl, E- _{5 to} E-8, E-24 to E-29, C _{5 to} C ₁₀ cycloalkenyl, —OR ²³ , —N ( R ²⁴ ) R ²³ , -S (O) _r R ²⁵ , -C (O) R ²⁶ , -C (R ²⁶ ) = NOH, -C (R ²⁶ ) = NOR ²⁷ , M-5, -C (O ) OR ²⁷ , -C (O) SR ²⁷ , -C (O) N (R ²⁹ ) R ²⁸ , M-11, M-28, -C (S) OR ²⁷ , -C (S) SR ²⁷ ,- C (S) N (R ²⁹ ) R ²⁸ , M-14, M-32, -C (O) C (O) OR ²⁷ , -S (O) ₂ N (R ²⁹ ) R ²⁸ , -Si (R ^13a ) (R ^13b ) R ¹³ , -P (O) (OR ¹⁹ ) ₂ , -P (S) (OR ¹⁹ ) ₂ , phenyl, phenyl substituted by (Z) _p1 , D-1 to D-5 , D-14, D-24, D-41, D-21 to D-23 or D-52 to D-59,
M-1 to M-48 each represents a partially saturated heterocyclic ring represented by the following structural formula,

R ¹⁶ represents -SH, -S (O) _r R ²⁵ or -S (O) _t (R ²⁵ ) = NR ^25a ,
R ^16a and R ^16b are each independently a hydrogen atom, a halogen atom, cyano, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ represents alkylthio, C ₁ -C ₄ alkylsulfinyl, C ₁ -C ₄ alkylsulfonyl, C ₁ -C ₄ alkyl Job aryloxycarbonyl, to -C (O) NH ₂ or -C (S) NH _2, respectively R ^16a and each R ^16b may be the same as or different from each other,
R ¹⁷ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³⁰ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E- 3 to E-6, E-8, E-10, E-24 to E-26, E-28, E-29, E-31, E-32, E-35, E-38, E-42, E-46, E-49, C 2 ~C 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl, C ₃ ~ C ₆ haloalkynyl, -C (O) R ²⁶ , -C (O) OR ²⁷ , -C (O) SR ²⁷ , -C (O) N (R ²⁹ ) R ²⁸ , -C (S) R ²⁶ , -C (S) OR ²⁷ , -C (S) SR ²⁷ , -C (S) N (R ²⁹ ) R ²⁸ , -S (O) ₂ R ²⁷ , -S (O) ₂ N (R ²⁹ ) R ²⁸ , -P (O) (OR ¹⁹ ) ₂ , -P (S) (OR ¹⁹ ) ₂ , phenyl, phenyl substituted by (Z) _p1 , D-1 to D-45 or D-47 to D- 65 represents
R ¹⁸ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfonyl (C ₁ -C ₄₎ alkyl, cyano (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ -C ₄₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, or represents C ₃ -C ₆ alkynyl or C ₃ -C ₆ haloalkynyl, Alternatively, R ¹⁸ represents that by together with R ¹⁷ forms a C ₂ -C ₆ alkylene chain, may form a 3- to 7-membered ring together with the nitrogen atom to which R ¹⁷ and R ¹⁸ are bonded In this case the alkylene chain is an oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₄ alkyl groups, C ₁ -C ₂ alkoxy (C ₁ -C ₂₎ alkyl groups, C ₁ -C ₄ alkoxy group, -CHO group may be optionally substituted by C ₁ -C ₄ alkylcarbonyl group or C ₁ -C ₄ alkoxycarbonyl group,
R ^17a is C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₁ -C ₁₂ alkoxy (C ₁ -C ₁₂ ) alkyl, cyano (C ₁ -C ₁₂ ) alkyl, C ₁ -C ₁₂ alkoxycarbonyl (C ₁ ~C ₁₂₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ halo alkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, C ₁ -C ₁₂ alkylcarbonyl, C ₁ -C ₁₂ alkoxycarbonyl, -C (O) ON = C (CH 3) SCH 3, -C (O) ON = C (SCH ₃ ) C (O) N (CH ₃ ) ₂ represents phenyl or phenyl substituted by (Z) _p1 ,
R ^18a is C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₁ -C ₁₂ alkoxy (C ₁ -C ₁₂ ) alkyl, cyano (C ₁ -C ₁₂ ) alkyl, C ₁ -C ₁₂ alkoxycarbonyl (C ₁ ~C ₁₂₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ halo alkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, phenyl or (Z) or represents phenyl which is substituted by _p1, or, R ^18a together with R ^17a C ₄ ~C ₇ alkylene By forming a chain, it represents that a 5- to 8-membered ring may be formed together with the nitrogen atom to which R ^17a and R ^18a are bonded. At this time, the alkylene chain may contain one oxygen atom or sulfur atom. may be optionally substituted and the C ₁ -C ₄ alkyl or C ₁ -C ₄ alkoxy group,
R ¹⁹ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ²⁰ is a halogen atom, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ -C ₄₎ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylamino, di (C ₁ -C ₆ alkyl) amino, C ₁ ~ C ₆ alkoxycarbonyl, phenyl or phenyl substituted by (Z) _{p 1} , and when q 1 to q 8 represent an integer of 2 or more, each R ²⁰ may be the same as or different from each other Well, furthermore, when two R ²⁰ are substituted on the same carbon atom, the two R ²⁰ together are oxo, thioxo, imino, C ₁ -C ₄ alkylimino, C ₁ -C ₄ alkoxy It indicates that may form an imino or C ₁ -C ₄ alkylidene,
R ²¹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³⁰ , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, -OH, ^{benzyloxy, -C (O) R 31,} -C (O) OR 32, -C (O) SR 32, -C (O) N (R 34 ) R ³³ , -C (S) N (R ³⁴ ) R ³³ , -S (O) ₂ R ³² , -P (O) (OR ¹⁹ ) ₂ , -P (S) (OR ¹⁹ ) ₂ , phenyl, (Z) represents phenyl or D-5 substituted by _p1 ,
R ²² is a halogen atom, cyano, C _{3 to} C ₈ cycloalkyl, C _{3 to} C ₈ halocycloalkyl, E-1 to E-50, C _{1 to} C ₆ alkoxy, C _{1 to} C ₆ haloalkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, C ₁ -C ₆ alkylamino, di (C ₁ -C ₆ alkyl) amino, - CHO, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, C ₁ -C ₆ alkylaminocarbonyl, di (C ₁ -C ₆ alkyl) aminocarbonyl, phenyl, (Z) phenyl substituted by _p1 or D-1 to D-65,
R ²³ is a hydrogen atom, C ₁ -C ₈ alkyl, optionally substituted by R ³⁰ (C ₁ ~C ₈₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally substituted by R ³⁰ (C ₃ -C ₈₎ cycloalkyl, E-3~E-6, E -8, E-10, E-24~E-26, E-28, E-29, E-31, E-32, E-35 , E-38, E-42 , E-46, E-49, C 3 ~C 8 alkenyl, optionally substituted by R ³⁰ (C ₃ ~C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, R ³⁰ optionally substituted by (C ₃ ~C ₈₎ ^{alkynyl, -C (O) R 31,} -C (O) OR 32, -C (O) SR 32, -C (O) N (R 34) R ³³ , -C (O) C (O) R ³² , -C (O) C (O) OR ³² , -C (S) R ³¹ , -C (S) OR ³² , -C (S) SR ³² , -C (S) N (R ³⁴ ) R ³³ , -S (O) ₂ R ³² , -S (O) ₂ N (R ³⁴ ) R ³³ , -Si (R ^13a ) (R ^13b ) R ¹³ ,- P (O) (OR ¹⁹ ) ₂ , -P (S) (OR ¹⁹ ) ₂ , phenyl, phenyl substituted by (Z) _p1 , D-1 to D-4, D-6 to D-13, D -15 to D-23, D-25 to D-37, D-39, D-40, D-42, D-43, D-45, D-47 or D-50 to D-65,
R ²⁴ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₄ cycloalkyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, C _{1 to} C ₆ alkoxy, phenyl or phenyl substituted by (Z) _{p 1} , or R ²⁴ together with R ²³ forms a C _{2 to} C ₅ alkylene chain, thereby allowing R ²³ and R ²⁴ represents that a 3- to 6-membered ring may be formed together with the nitrogen atom to which ²⁴ is bonded, in which case the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and a halogen atom, C _1- C ₄ alkyl group, C ₁ -C ₄ haloalkyl groups, C ₁ -C ₄ alkoxy group, -CHO group, C ₁ -C ₄ alkylcarbonyl group, C ₁ -C ₄ alkoxy May be substituted by a xycarbonyl group, a phenyl group, a phenyl group substituted by (Z) _p1 , an oxo group or a thioxo group,
R ²⁵ is, C ₁ -C ₈ alkyl, optionally substituted by R ³⁰ (C ₁ ~C ₈₎ alkyl, optionally substituted by C ₃ -C ₈ cycloalkyl, R ³⁰ (C ₃ ~C ₈ ) Cycloalkyl, E-3, E-4, E-6, E-8, E-10, E-25, E-26, E-28, E-29, E-31, E-32, E- 35, E-38, E- 42, E-46, E-49, C 3 ~C 8 alkenyl, optionally substituted by R ³⁰ (C ₃ ~C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, R optionally substituted by ³⁰ (C ₃ ^~C ₈₎ ^{alkynyl, -C (O) R 31,} -C (O) OR 32, -C (O) SR 32, -C (O) N (R 34) R ³³ , -C (O) C (O) R ³² , -C (O) C (O) OR ³² , -C (S) R ³¹ , -C (S) OR ³² , -C (S) SR ³² , -C (S) N (R 34) R 33, -SH, C 1 ~C 6 alkylthio, C ₁ -C ₆ haloalkylthio, phenylthio, phenylthio substituted by _{(Z) p1, -P (O} ) ( _{^{OR 19) 2, -P (S}} ) (OR 19) 2, phenyl, (Z) phenyl substituted by _{p1, D-18, D-} 21, D-25, D-30~D-35, D- 50, D-52, D-55, D-56, D-58 It represents the D-59,
R ^25a is a hydrogen atom, cyano, nitro, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, represents C ₁ -C ₆ alkylsulfonyl or C ₁ -C ₆ haloalkylsulfonyl,
R ²⁶ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ haloalkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylsulfonyl (C _{1 ~C 4)} alkyl, C ₁ -C ₆ haloalkylsulfonyl (C _{1 ~C 4)} alkyl, phenyl (C _{1 ~C 4)} alkyl, phenyl substituted by (Z) _p1 (C ₁ ~C ₄₎ represents alkyl, C ₃ -C ₆ cycloalkyl, phenyl substituted by phenyl or (Z) _p1,
R ²⁷ is optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ³⁰ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ³⁰ (C ₃ ~C ₈ ) Cycloalkyl, E-3 to E-6, E-8, E-10, E-24 to E-26, E-28, E-29, E-31, E-32, E-35, E- 38, E-42, E- 46, E-49, C 2 ~C 6 alkenyl, optionally substituted by R ³⁰ (C ₂ ~C ₆₎ alkenyl, C ₃ -C ₆ alkynyl, optionally by R ³⁰ substituted (C ₃ ~C ₆₎ alkynyl, phenyl, (Z) phenyl substituted by _{p1, D-1~D-4,} D-6~D-13, D-15~D-23, D- 25-D-37, D-39, D-40, D-42, D-43, D-45, D-47 or D-50-D-65,
R ²⁸ is a hydrogen atom, C ₁ -C ₆ alkyl, optionally substituted by R ³⁰ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally substituted by R ³⁰ (C ₃ -C ₈₎ cycloalkyl, E-3~E-6, E -8, E-10, E-24~E-26, E-28, E-29, E-31, E-32, E-35 , E-38, E-42 , E-46, E-49, C 2 ~C 6 alkenyl, optionally substituted by R ³⁰ (C ₂ ~C ₆₎ alkenyl, C ₃ -C ₈ alkynyl, R ³⁰ optionally substituted by (C ₃ ~C ₆₎ alkynyl, phenyl, represents phenyl, D-1 to D-45 or D-47~D-65 substituted by (Z) _p1,
R ^28a represents a hydrogen atom or a C ₁ -C ₄ alkyl,
R ²⁹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted with R ³⁰ , C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C Represents ₆ alkynyl, C ₃ -C ₆ haloalkynyl, phenyl or phenyl substituted by (Z) _{p 1} , or R ²⁹ together with R ²⁸ forms a C ₂ -C ₅ alkylene chain , R ²⁸ and R ²⁹ may form a 3- to 6-membered ring together with the nitrogen atom to which R ²⁸ and R ²⁹ are bonded, wherein the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and halogen atom, C ₁ -C ₄ alkyl group, C ₁ -C ₄ alkoxy group, -CHO group, C ₁ -C ₄ alkylcarbonyl group, C ₁ -C ₄ alkoxycarbonyl group, a phenyl group, substituted by (Z) _p1 Optionally substituted by a phenyl group or an oxo group,
R ³⁰ is a halogen atom, cyano, nitro, C _{3 to} C ₈ cycloalkyl, C _{3 to} C ₈ halocycloalkyl, E-5 to E-8, E-11 to E-13, E-19, E- 20, E-24~E-29, E-33~E-36, E-44~E-46, C 2 ~C 6 alkenyl, C ₂ -C ₆ haloalkenyl, -OH, -OR ^32, -OC (O) R ³¹ , -OC (O) OR ³² , -OC (O) N (R ³⁴ ) R ³³ , -OC (S) N (R ³⁴ ) R ³³ , -SH, -S (O) _r R ³² , -SC (O) R ³¹ , -SC (O) OR ³² , -SC (O) N (R ³⁴ ) R ³³ , -SC (S) N (R ³⁴ ) R ³³ , -N (R ³⁴ ) R ³³ , -N (R ³⁴ ) CHO, -N (R ³⁴ ) C (O) R ³¹ , -N (R ³⁴ ) C (O) OR ³² , -N (R ³⁴ ) C (O) N (R ³⁴ ) R ³³ , -N (R ³⁴ ) C (S) N (R ³⁴ ) R ³³ , -N (R ³⁴ ) S (O) ₂ R ³² , -C (O) R ³¹ , -C (O) OH, -C (O) OR ³² , -C (O) SR ³² , -C (O) N (R ³⁴ ) R ³³ , -C (O) C (O) OR ³² , -Si (R ^13a ) ( R ^13b ) R ¹³ , -P (O) (OR ¹⁹ ) ₂ , -P (S) (OR ¹⁹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , phenyl, (Z) represents phenyl substituted by _p1 or D-1 to D-65;
R ³¹ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³⁵ , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, E-5~E-8, E -24~E-29, C 2 ~C 8 alkenyl, C ₂ -C ₈ haloalkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo represents cycloalkenyl, C ₂ -C ₈ alkynyl, C ₂ -C ₈ haloalkynyl, phenyl, phenyl or D-1 to D-65 substituted by (Z) _p1,
R ³² is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³⁵ , C ₃ -C ₆ cycloalkyl, E-6, E-8 , C ₂ -C ₈ represents alkenyl, C ₂ -C ₈ haloalkenyl, a C ₃ -C ₈ alkynyl or phenyl,
R ³³ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³⁵ , C ₃ -C ₆ cycloalkyl, E-5, E-6 , E-8, E-24 , C 2 ~C 8 alkenyl, C ₂ -C ₈ haloalkenyl, C ₃ -C ₈ alkynyl, phenyl, phenyl substituted by _{(Z) p1, D-1~D} -45 Or D-47 to D-65,
R ³⁴ represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₈ cycloalkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl, or R ³⁴ Represents that, together with R ³³ , a C ₂ -C ₅ alkylene chain may be formed to form a 3- to 6-membered ring with the nitrogen atom to which R ³³ and R ³⁴ are bonded. alkylene chain oxygen atom may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₄ alkyl group, C ₁ -C ₄ alkoxy group, -CHO group, C ₁ -C ₄ alkylcarbonyl group , C ₁ -C ₄ alkoxycarbonyl group, may be optionally substituted by a phenyl group substituted by a phenyl group or (Z) _p1,
R ³⁵ is cyano, C _{3 to} C ₆ cycloalkyl, C _{3 to} C ₆ halocycloalkyl, E-5 to E-8, E-24 to E-29, C _{1 to} C ₄ alkoxy, C _{1 to} C ₄ haloalkoxy, phenoxy, (Z) _p1 phenoxy substituted by, C ₁ -C ₄ alkylthio, C ₁ -C ₄ haloalkylthio, phenylthio, (Z) phenylthio substituted by _p1, C ₁ -C ₄ alkylsulfonyl , C ₁ -C ₄ haloalkylsulfonyl, phenylsulfonyl, (Z) phenylsulfonyl substituted by ^{_{p1, -N (R 37) R}} 36, C 1 ~C 6 alkyl carbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, di (C ₁ -C ₆ alkyl) aminocarbonyl, tri (C ₁ -C ₄ alkyl) silyl, phenyl, (Z) phenyl substituted by _p1, naphthyl or D-1 to D-65 Represents
R ³⁶ is phenyl substituted by a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, phenylcarbonyl or (Z) _p1 Represents carbonyl,
R ³⁷ represents a hydrogen atom or C ₁ -C ₆ alkyl,
m represents an integer of 0 to 5;
n represents an integer of 2 to 4,
p1 represents an integer of 1 to 5,
p2 represents an integer of 0 to 4,
p3 represents an integer of 0 to 3,
p4 represents an integer of 0 to 2,
p5 represents an integer of 0 or 1,
q1 represents an integer of 0 to 2,
q2 represents an integer of 0 to 3,
q3 represents an integer of 0 to 4,
q4 represents an integer of 0 to 5,
q5 represents an integer of 0 to 6,
q6 represents an integer of 0 to 7,
q7 represents an integer of 0 to 8,
q8 represents an integer of 0 to 9,
r represents an integer of 0 to 2;
t represents an integer of 0 or 1. ]
Or a salt thereof. A ¹ , A ² and A ⁴ each independently represent CY or N;
A ³ represents CH or N,
G represents a benzene ring,
L is -C (R ⁴ ) (R ^4a )-, -C (R ⁴ ) (R ^4a ) CH _2- , -N (R ^4b )-or -C (R ⁴ ) (R ^4a ) N (R ^4b )-
X is a halogen atom, cyano, nitro, -SF _5, C ₁ ~C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ ~C ₄₎ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) Represents haloalkyl, —OR ⁶ , —S (O) _r R ⁶ or —NH _2, and when m represents an integer of 2 or more, each X may be the same as or different from each other. ,
Further, when two X are adjacent, the two X adjacent the _{-CF 2 OCF 2 -, - OCF} 2 O -, - CF 2 OCF 2 O- or -OCF ₂ CF ₂ O-to form a May form a 5- or 6-membered ring with the carbon atom to which each is attached,
Y is a hydrogen atom, a halogen atom, cyano, nitro, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, substituted by R ⁵ (C ₁ ~C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C _{2 to} C ₆ alkynyl, -OR ⁶ , -S (O) _r R ⁶ , -N (R ⁸ ) R ⁷ , -C (S) NH ₂ , D-1 to D-5, D-14, D- 24 or D-41, when two or more Y are present, each Y may be the same as or different from each other;
Further, when two Ys are adjacent to each other, the two adjacent Ys may form a 6-membered ring with the carbon atom to which each of the two Ys is bonded by forming -CH = CHCH = CH-. Often,
R ¹ is a hydrogen atom, -C (O) R ^1a , -C (O) OR ^1b , -C (O) SR ^1b , -C (O) N (R ^1d ) R ^1c , -C (S) R ^1a , -C (S) OR ^1b , -C (S) SR ^1b , -C (S) N (R ^1d ) R ^1c or -S (O) ₂ R ^1b
R ^1a is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ ,-[C (R ^16a ) (R ^16b )] _n − R ¹⁶ , C ₃ -C ₇ cycloalkyl, C ₃ -C ₆ halocycloalkyl, cyano (C ₃ -C ₆ ) cycloalkyl, phenyl (C ₃ -C ₆ ) cycloalkyl, E-5, E-6, E-21, E-22, E-24~E-26, C 2 ~C 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ alkynyl, C ₂ -C ₆ haloalkynyl, -C (O ) R ⁹ , -C (R ⁹ ) = NOR ¹⁰ , M-7, -C (O) OR ¹⁰ , -C (O) N (R ¹² ) R ¹¹ , phenyl, phenyl substituted by (Z) _p1 , D-1 to D-4, D-15 to D-17, D-21 to D-24 or D-52 to D-59,
R ^1b represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl or phenyl,
R ^1c is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , -CH ₂ CH ₂ -R ¹⁶ , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ ^{alkynyl, -C (R 9) = NOR} 10, C 1 ~C 6 alkoxycarbonyl, M-14, M-32 , C 1 ~C 6 alkoxy, C ₁ -C ₆ ^{alkylsulfonyl, -N (R 18) R 17} , represents phenyl, phenyl or D-52~D-54 substituted by (Z) _p1,
R ^1d represents a hydrogen atom, C ₁ -C ₆ alkyl or benzyl, or R ^1d together with R ^1c forms a C ₄ -C ₅ alkylene chain, whereby R ^1c and R ^1d are with bound nitrogen atom indicates that may form a 5- or 6-membered ring, this time the alkylene chain an oxygen atom, may contain one sulfur atom or a nitrogen atom, and C ₁ -C ₄ alkyl group, -CHO group, C ₁ -C ₄ alkylcarbonyl group, C ₁ -C ₄ alkoxycarbonyl group, C ₁ -C ₄ alkylaminocarbonyl group, C ₁ -C ₄ halo alkylaminocarbonyl group, di (C ₁ -C ₄ alkyl Optionally substituted by an aminocarbonyl group or an oxo group,
R ² is a hydrogen atom, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ^15a , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkylthio or -SN (R ^18a) R ^17a or it represents, or, R ² is by together with R ¹ to form a C ₄ -C ₆ alkylene chain, may form a 5- to 7 membered ring together with the nitrogen atom R ¹ and R ² are bonded indicates that, this time the alkylene chain an oxygen atom, may contain one sulfur atom or a nitrogen atom, and C ₁ -C ₄ alkyl group, C ₁ -C ₄ alkylidene group, optionally by an oxo group or thioxo group May be replaced,
R ³ represents C ₁ -C ₆ haloalkyl or C ₃ -C ₈ halocycloalkyl,
R ⁴ is a hydrogen atom, cyano, C ₁ -C ₃ alkyl, C ₁ -C ₃ haloalkyl, C ₃ -C ₄ cycloalkyl, C ₂ -C ₃ alkynyl, -C (O) NH ₂ , -C (S ) Represents NH ₂ , phenyl, D-18 or D-21,
R ^4a represents a hydrogen atom or C ₁ -C ₃ alkyl, or R ^4a together with R ⁴ forms an ethylene chain to form cyclopropyl together with the carbon atom to which R ⁴ and R ^4a are attached. Represents that a ring may be formed,
R ^4b represents a hydrogen atom, C ₁ -C ₃ alkyl, C ₁ -C ₃ alkylcarbonyl, a C ₃ -C ₄ cycloalkyl carbonyl or C ₁ -C ₃ alkoxycarbonyl,
Z is a halogen atom, cyano, nitro, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ alkylthio or C ₁ -C ₄ represents haloalkylthio, and when p1 to p4 represent an integer of 2 or more, each Z may be the same as or different from each other;
R ⁵ represents -OH, C ₁ -C ₄ alkoxy, C ₁ -C ₄ alkylthio, C ₁ -C ₄ alkylsulfinyl or C ₁ -C ₄ alkylsulfonyl,
R ⁶ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₄ haloalkoxy (C ₁ -C ₄ ) haloalkyl,
R ⁷ represents a hydrogen atom, C ₁ -C ₆ alkyl, —CHO, C ₁ -C ₆ alkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl,
R ⁸ represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ⁹ represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ¹⁰ represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ¹¹ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or C ₃ -C ₆ cycloalkyl,
R ¹² represents a hydrogen atom,
R ¹⁴ represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ¹⁵ is cyano, C _{3 to} C ₆ cycloalkyl, E-5 to E-8, E-24, E-25, E-27, E-28, C _{5 to} C ₆ cycloalkenyl, —OR ²³ , -N (R ²⁴ ) R ²³ , -C (O) OR ²⁷ , -C (O) N (R ²⁹ ) R ²⁸ , -C (S) N (R ²⁹ ) R ²⁸ , -C (= NOH) N ^{(R 29) R 28, -C} (= NOR 27) N (R 29) R 28, tri (C ₁ ~C ₄₎ alkylsilyl, phenyl, phenyl substituted by _{(Z) p1, D-1} , D -3, D-21, D-22 or D-52 to D-54,
R ^15a is cyano, C ₃ -C ₆ cycloalkyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ alkylthio, C ₁ -C ₄ alkylsulfinyl, C ₁ -C ₄ alkyl Represents sulfonyl, -N (R ²⁴ ) R ²³ , -C (O) OR ²⁷ , -C (O) N (R ²⁹ ) R ²⁸ , -C (S) NH ₂ or phenyl;
R ¹⁶ represents -S (O) _r R ²⁵ or -S (O) _t (R ²⁵ ) = NR ^25a ,
R ^16a and R ^16b each independently represent a hydrogen atom or C ₁ -C ₂ alkyl, each R ^16a and each R ^16b may be the same or different from each other,
R ¹⁷ is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, -C (O) R ²⁶ , -C (O) OR ²⁷ , -C (O) N (R ²⁹ ) R ²⁸ , -C (S) N (R ²⁹ ) R ²⁸ , phenyl or phenyl substituted by (Z) _p1 ,
R ¹⁸ represents a hydrogen atom or C ₁ -C ₄ alkyl, or R ¹⁸ together with R ¹⁷ forms a C ₄ -C ₅ alkylene chain, thereby binding R ¹⁷ and R ¹⁸ Represents that a 5- to 6-membered ring may be formed together with the nitrogen atom, and this alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and a C ₁ -C ₄ alkyl group, —CHO group may be optionally substituted by C ₁ -C ₄ alkylcarbonyl group or C ₁ -C ₄ alkoxycarbonyl group,
R ^17a represents C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxycarbonyl (C ₁ -C ₄ ) alkyl or C ₁ -C ₆ alkoxycarbonyl,
R ^18a represents C ₁ -C ₆ alkyl or benzyl,
R ²⁰ represents C ₁ -C ₂ alkyl, and when q 3, q 4 and q 5 represent 2, each R ²⁰ may be the same as or different from each other,
R ²¹ represents a hydrogen atom, C ₁ -C ₄ alkylcarbonyl or C ₁ -C ₄ alkoxycarbonyl,
R ²³ is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ cycloalkyl (C ₁ ~C ₂₎ alkyl, cyano (C ₁ ~C ₂₎ alkyl, C ₃ ~ C ₄ cycloalkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ ^{alkynyl, -C (O) R 31,} -C (O) OR 32, -C (O) SR 32, -C (O) N ( R ³⁴ ) R ^{33 represents} C ₁ -C ₄ alkylsulfonyl, C ₁ -C ₄ haloalkylsulfonyl, phenyl or phenyl substituted by (Z) _p1 ;
R ²⁴ is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ alkylcarbonyl, C ₁ -C ₄ haloalkylcarbonyl, C ₁ -C ₄ alkoxy or a carbonyl or C ₁ -C ₄ alkylsulfonyl, or , R ²⁴ together with R ²³ represents a C _{4 to} C ₅ alkylene chain, thereby forming a 5- to 6-membered ring together with the nitrogen atom to which R ²³ and R ²⁴ are bonded; At this time, the alkylene chain may contain one oxygen atom or sulfur atom, and may be optionally substituted with an oxo group,
R ²⁵ is C ₁ -C ₄ alkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³⁰ , C ₃ -C ₄ alkenyl, C ₃ -C ₄ alkynyl, -C (O) R ³¹ , Represents -C (O) OR ³² or -C (O) N (R ³⁴ ) R ³³ ,
R ^25a represents a hydrogen atom, cyano or C ₁ -C ₂ haloalkylcarbonyl,
R ²⁶ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₆ cycloalkyl or phenyl;
R ²⁷ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or C ₃ -C ₆ cycloalkyl,
R ²⁸ is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ cycloalkyl (C ₁ -C ₂ ) alkyl, C ₃ -C ₆ cycloalkyl or C ₁ -C ₄ Represents haloalkylcarbonyl,
R ²⁹ represents a hydrogen atom or C ₁ -C ₄ alkyl, or R ²⁹ together with R ²⁸ forms a C ₄ -C ₅ alkylene chain, thereby bonding R ²⁸ and R ²⁹ . Represents that a 5- to 6-membered ring may be formed together with the nitrogen atom, in which case the alkylene chain may contain one oxygen atom or sulfur atom, and may be optionally substituted with an oxo group,
R ³⁰ represents a halogen atom, cyano or -C (O) N (R ³⁴ ) R ³³ ,
R ³¹ is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₂ alkoxy (C ₁ -C ₂ ) alkyl, C ₃ -C ₆ cycloalkyl, phenyl, D-24 or D-52 ~ Represents D-54,
R ³² represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ³³ represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ³⁴ represents a hydrogen atom or C ₁ -C ₄ alkyl,
m represents an integer of 1 to 3,
n represents 2,
p2 represents an integer of 0 to 3,
p3 represents an integer of 0 to 2,
p5 represents 1,
q2 represents 0,
q3 and q5 represent an integer of 0 to 2,
q4 represents an integer of 0 to 2,
The substituted isoxazoline compound or a salt thereof according to claim 1, wherein q6 and q8 represent 0. A ¹ represents CY or N,
A ² and A ³ represent CH,
A ⁴ represents CH or N;
L represents -C (R ⁴ ) (R ^4a )-
X is a halogen atom, cyano, nitro, -SF _5, C ₁ ~C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ alkylthio or When C represents C ₁ -C ₄ haloalkylthio and m represents 2 or 3, each X may be the same as or different from each other;
Y is a hydrogen atom, a halogen atom, cyano, nitro, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₂ -C ₄ alkynyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ represents alkylthio, a C ₁ -C ₄ haloalkylthio or -C (S) NH _2,
R ¹ is -C (O) R ^1a , -C (O) OR ^1b , -C (O) SR ^1b , -C (O) N (R ^1d ) R ^1c , -C (S) R ^{1a or-} C (S) N (R ^1d ) R ^1c
R ^1a is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , -CH ₂ CH ₂ -R ¹⁶ , C ₃ -C ₄ cycloalkyl, E-5, E-6 , C 2 ~C 4 alkenyl, C ₂ -C ₄ haloalkenyl, C ₂ -C ₄ ^{alkynyl, -C (R 9) = NOR} 10, is substituted by (Z) _p1 Represents phenyl, D-3, D-17 or D-53,
R ^1b represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ^1c is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , C ₃ -C ₄ cycloalkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ represents an alkynyl, a C ₁ -C ₄ alkoxy, C ₁ -C ₄ alkylsulfonyl or -N (R ¹⁸⁾ R ^17,
R ^1d represents a hydrogen atom or C ₁ -C ₄ alkyl, or R ^1d together with R ^1c forms a C ₄ -C ₅ alkylene chain, thereby binding R ^1c and R ^1d . It represents that a 5- to 6-membered ring may be formed together with a nitrogen atom, and this alkylene chain may contain one oxygen atom or sulfur atom, and may be optionally substituted with a methyl group or an oxo group. Often,
R ² represents a hydrogen atom, C ₁ -C ₄ alkyl, (C ₁ -C ₂ ) alkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ alkynyl or C ₁ -C ₄ alkoxy substituted by R ^15a . Represent,
R ³ represents C ₁ -C ₄ haloalkyl,
R ⁴ represents a hydrogen atom, cyano, methyl, trifluoromethyl, ethynyl or —C (S) NH ₂ ;
R ^4a represents a hydrogen atom, or R ^4a together with R ⁴ may form an ethylene chain to form a cyclopropyl ring together with the carbon atom to which R ⁴ and R ^4a are bonded. Represents
Z is a halogen atom, cyano, nitro, C ₁ -C ₄ alkyl or C ₁ -C ₄ alkylthio, when p1 and p2 represents an integer of 2 or more, each Z may may be the same with each other or one another They may be different,
R ⁹ represents a hydrogen atom,
R ¹⁰ represents C ₁ -C ₂ alkyl,
R ¹⁴ represents C ₁ -C ₂ alkyl,
R ¹⁵ is cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or -C (O) N (R ²⁹ ) R ²⁸ Represents
R ^15a is cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, C ₁ -C ₂ alkylthio, -N (R ²⁴ ) R ²³ , C ₁ -C ₂ alkoxycarbonyl, it represents a ^{-C (O) N (R 29} ) R 28 or -C (S) NH _2,
R ¹⁶ represents -S (O) _r R ²⁵ ,
R ¹⁷ represents a hydrogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₂ alkoxycarbonyl,
R ¹⁸ represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ²³ is C ₁ -C ₂ alkyl, cyano (C ₁ -C ₂ ) alkyl, -C (O) R ³¹ , -C (O) OR ³² , -C (O) SR ³² or C ₁ -C ₂ Represents alkylsulfonyl,
R ²⁴ represents a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkylcarbonyl, C ₁ -C ₂ alkoxycarbonyl or C ₁ -C ₂ alkylsulfonyl,
R ²⁵ represents C ₁ -C ₂ alkyl,
R ²⁸ represents a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyclopropylmethyl,
R ²⁹ represents a hydrogen atom or C ₁ -C ₂ alkyl,
R ³¹ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or C ₃ -C ₄ cycloalkyl,
R ³² represents C ₁ -C ₂ alkyl,
p1 represents an integer of 1 to 3,
p2 represents an integer of 0 to 2,
p3 and p4 represent an integer of 0 or 1,
The substituted isoxazoline compound or a salt thereof according to claim 2, wherein t represents 0. L represents -CH (R ⁴ )-
X represents a halogen atom, cyano, —SF ₅ , C ₁ -C ₂ haloalkyl, C ₁ -C ₂ haloalkoxy or C ₁ -C ₂ haloalkylthio, and when m represents 2 or 3, each X is They may be the same or different from each other,
Y is a hydrogen atom, a halogen atom, cyano, nitro, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl, C ₂ -C ₃ alkynyl, C ₁ -C ₂ haloalkoxy, C ₁ -C ₂ haloalkylthio or represents -C (S) NH _2,
R ¹ represents -C (O) R ^1a , -C (O) SR ^1b , -C (O) N (R ^1d ) R ^1c or -C (S) R ^1a ,
R ^1a is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , C ₃ -C ₄ cycloalkyl, E-6, C ₂ -C ₄ represents alkenyl, C ₂ -C ₄ haloalkenyl, C ₂ -C ₄ alkynyl, phenyl or D-53 substituted by (Z) _p1,
R ^1b represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ^1c represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ cycloalkyl or C ₃ -C ₄ alkynyl,
R ^1d represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ² represents a hydrogen atom, C ₁ -C ₄ alkyl, (C ₁ -C ₂ ) alkyl substituted by R ^15a , C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ³ represents C ₁ -C ₂ haloalkyl,
R ⁴ represents a hydrogen atom, cyano, methyl, ethynyl or —C (S) NH ₂ ;
Z represents a halogen atom, cyano, nitro or C ₁ -C ₄ alkylthio, when p1 and p2 represents an integer of 2 or more, each Z may be the even or different from each other the same as each other,
R ¹⁵ represents C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or -C (O) N (R ²⁹ ) R ²⁸ ,
R ^15a represents cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or C ₁ -C ₂ alkoxycarbonyl,
R ²³ represents cyano (C ₁ -C ₂ ) alkyl, -C (O) R ³¹ or C ₁ -C ₂ alkoxycarbonyl,
R ²⁴ represents a hydrogen atom or C ₁ -C ₂ alkoxycarbonyl,
R ²⁸ represents a hydrogen atom or C ₁ -C ₂ alkyl,
The substituted isoxazoline compound or a salt thereof according to claim 3, wherein R ³¹ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyclopropyl. A ¹ represents CY,
A ⁴ represents CH,
X represents a halogen atom or trifluoromethyl, and when m represents 2 or 3, each X may be the same as or different from each other;
Y represents a hydrogen atom, a halogen atom, nitro or methyl,
R ¹ represents -C (O) R ^1a or -C (O) NHR ^1c ,
R ^1a represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, cyclopropylmethyl, cyclopropyl or E-6,
R ^1c represents C ₁ -C ₃ alkyl, C ₁ -C ₃ haloalkyl, cyclopropyl or propargyl,
R ² represents a hydrogen atom, C ₁ -C ₂ alkyl, cyclopropylmethyl, C ₁ -C ₂ alkoxymethyl, cyanomethyl, allyl or propargyl,
R ³ represents trifluoromethyl or chlorodifluoromethyl,
The substituted isoxazoline compound or a salt thereof according to claim ⁴ , wherein R ⁴ represents a hydrogen atom, cyano or methyl. General formula (1a):

[Wherein A ¹ represents CY or N;
A ⁴ represents CH or N;
Y is a hydrogen atom, a halogen atom, cyano, nitro, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl, C ₂ -C ₃ alkynyl, C ₁ -C ₂ haloalkoxy, C ₁ -C ₂ haloalkylthio or represents -C (S) NH _2,
R ¹ represents -C (O) R ^1a or -C (S) R ^1a ,
R ^1a is -C (R ^16a ) (R ^16b ) -S (O) _r R ²⁵ , -C (R ^16a ) (R ^16b ) -S (O) _t (R ²⁵ ) = NR ^25a , E-7 , E-8, E-51 or E-52,
R ² represents a hydrogen atom, C ₁ -C ₂ alkyl, methyl, allyl or propargyl substituted by R ^15a ;
R ³ represents C ₁ -C ₂ haloalkyl,
R ⁴ represents a hydrogen atom, cyano, methyl, ethynyl or —C (S) NH ₂ ;
E-7, E-8, E-51 and E-52 each represent a saturated heterocyclic ring represented by the following structural formula,

R ^15a is cyano, cyclopropyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, C ₁ -C ₂ alkoxycarbonyl, -C (O) N (R ²⁹ ) R ²⁸ or -C (S) NH ₂
R ^16a represents a hydrogen atom, a fluorine atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ alkylthio or C ₁ -C ₂ alkylsulfinyl,
R ^16b represents a hydrogen atom or a fluorine atom,
R ²⁵ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyanomethyl;
R ^25a represents a hydrogen atom or C ₁ -C ₂ haloalkylcarbonyl,
R ²⁸ represents a hydrogen atom or C ₁ -C ₂ alkyl,
R ²⁹ represents a hydrogen atom or methyl,
q6 represents 0,
r represents an integer of 0 to 2;
t represents an integer of 0 or 1. ]
Or a salt thereof. A ¹ represents CY,
A ⁴ represents CH,
Y represents a hydrogen atom, a halogen atom, nitro or methyl,
R ^1a represents -C (R ^16a ) (R ^16b ) -S (O) _r R ²⁵ or E-7,
R ² represents a hydrogen atom, C ₁ -C ₂ alkyl or propargyl,
R ³ represents trifluoromethyl or chlorodifluoromethyl,
R ⁴ represents a hydrogen atom or methyl,
R ^16a is a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ alkylthio or C ₁ -C ₂ alkylsulfinyl,
R ^16b represents a hydrogen atom,
The substituted isoxazoline compound or a salt thereof according to claim 6, wherein R ²⁵ represents C ₁ -C ₂ alkyl or C ₁ -C ₂ haloalkyl. General formula (2):

[Wherein A ¹ represents CY or N;
A ⁴ represents CH or N;
J represents a hydrogen atom or a halogen atom,
L represents -C (R ⁴ ) (R ^4a )-
Y is a hydrogen atom, a halogen atom, cyano, nitro, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₂ -C ₄ alkynyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy or - It represents C (S) NH _2,
R ¹ is -C (O) R ^1a , -C (O) OR ^1b , -C (O) SR ^1b , -C (O) N (R ^1d ) R ^1c , -C (S) R ^{1a or-} C (S) N (R ^1d ) R ^1c
R ^1a is a hydrogen atom, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ ,-[C (R ^16a ) (R ^16b )] _n − R ^16, C ₃ ~C ₄ cycloalkyl, E-5~E-8, E -51, E-52, C 2 ~C 4 alkenyl, C ₂ -C ₄ haloalkenyl, C ₂ -C ₄ alkynyl, ( Z) represents phenyl, D-3, D-17 or D-53 substituted by _p1 ,
R ^1b represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ^1c is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , C ₃ -C ₄ cycloalkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ represents an alkynyl, a C ₁ -C ₄ alkoxy, C ₁ -C ₄ alkylsulfonyl or -N (R ¹⁸⁾ R ^17,
R ^1d represents a hydrogen atom or C ₁ -C ₄ alkyl, or R ^1d together with R ^1c forms a C ₄ -C ₅ alkylene chain, thereby binding R ^1c and R ^1d . It represents that a 5- to 6-membered ring may be formed together with a nitrogen atom, and this alkylene chain may contain one oxygen atom or sulfur atom, and may be optionally substituted with a methyl group or an oxo group. Often,
R ² represents a hydrogen atom, C ₁ -C ₄ alkyl, (C ₁ -C ₂ ) alkyl, C ₃ -C ₄ alkenyl, C ₃ -C ₄ alkynyl or C ₁ -C ₄ alkoxy substituted by R ^15a . Represent,
R ⁴ represents a hydrogen atom, cyano, methyl, trifluoromethyl, ethynyl or —C (S) NH ₂ ;
R ^4a represents a hydrogen atom, or R ^4a together with R ⁴ may form an ethylene chain to form a cyclopropyl ring together with the carbon atom to which R ⁴ and R ^4a are bonded. Represents
D-3, D-17 and D-53 each represent an aromatic heterocycle represented by the following structural formula,

Z represents a halogen atom, cyano, nitro or C ₁ -C ₄ alkyl, when p1 and p2 represents an integer of 2 or more, each Z may be the even or different from each other the same as each other,
R ¹⁴ represents C ₁ -C ₂ alkyl,
E-5 to E-8, E-51 and E-52 each represent a saturated heterocyclic ring represented by the following structural formula,

R ¹⁵ is cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or -C (O) N (R ²⁹ ) R ²⁸ Represents
R ^15a is cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ , C ₁ -C ₂ alkoxycarbonyl, -C (O ) N (R ²⁹ ) R ²⁸ or -C (S) NH ₂
R ¹⁶ represents -S (O) _r R ²⁵ or -S (O) _t (R ²⁵ ) = NR ^25a ,
R ^16a represents a hydrogen atom, a fluorine atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ alkylthio or C ₁ -C ₂ alkylsulfinyl,
R ^16b represents a hydrogen atom or a fluorine atom,
R ¹⁷ represents a hydrogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₂ alkoxycarbonyl,
R ¹⁸ represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ²³ is C ₁ -C ₂ alkyl, cyano (C ₁ -C ₂ ) alkyl, -C (O) R ³¹ , -C (O) OR ³² , -C (O) SR ³² or C ₁ -C ₂ Represents alkylsulfonyl,
R ²⁴ represents a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkylcarbonyl, C ₁ -C ₂ alkoxycarbonyl or C ₁ -C ₂ alkylsulfonyl,
R ²⁵ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyanomethyl;
R ^25a represents a hydrogen atom or C ₁ -C ₂ haloalkylcarbonyl,
R ²⁸ represents a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyclopropylmethyl,
R ²⁹ represents a hydrogen atom or C ₁ -C ₂ alkyl,
R ³¹ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or C ₃ -C ₄ cycloalkyl,
R ³² represents C ₁ -C ₂ alkyl,
n represents an integer of 1 or 2,
p1 represents an integer of 1 to 3,
p2 represents an integer of 0 to 2,
p3 and p4 represent an integer of 0 or 1,
q6 represents 0,
r represents an integer of 1 or 2,
t represents an integer of 0 or 1. ]
The substituted benzaldoxime compound or its salt represented by these. L represents -CH (R ⁴ )-
Y is a hydrogen atom, a halogen atom, cyano, nitro, C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl, C ₂ -C ₃ alkynyl, C ₁ -C ₂ haloalkoxy or -C (S) NH ₂ Represent,
R ¹ represents -C (O) R ^1a , -C (O) SR ^1b , -C (O) N (R ^1d ) R ^1c or -C (S) R ^1a ,
R ^1a is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, (C ₁ -C ₂ ) alkyl substituted by R ¹⁵ , -C (R ¹⁶ ) (R ^16a ) -S (O) _r- R ²⁵ , C ₃ -C ₄ cycloalkyl, E-6, E-7, C ₂ -C ₄ alkenyl, C ₂ -C ₄ haloalkenyl, C ₂ -C ₄ alkynyl, phenyl substituted by (Z) _p1 Or D-53,
R ^1b represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ^1c represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ cycloalkyl or C ₃ -C ₄ alkynyl,
R ^1d represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ² represents a hydrogen atom, C ₁ -C ₄ alkyl, (C ₁ -C ₂ ) alkyl substituted by R ^15a , C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ⁴ represents a hydrogen atom, cyano, methyl, ethynyl or —C (S) NH ₂ ;
Z represents a halogen atom, cyano or nitro, and when p1 and p2 represent an integer of 2 or more, each Z may be the same as or different from each other;
R ¹⁵ represents C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or -C (O) N (R ²⁹ ) R ²⁸ ,
R ^15a represents cyano, C ₃ -C ₄ cycloalkyl, C ₁ -C ₂ alkoxy, C ₁ -C ₂ haloalkoxy, -N (R ²⁴ ) R ²³ or C ₁ -C ₂ alkoxycarbonyl,
R ¹⁶ represents a hydrogen atom, C ₁ -C ₂ alkyl, C ₁ -C ₂ alkylthio or C ₁ -C ₂ alkylsulfinyl,
R ^16a represents a hydrogen atom,
R ²³ represents cyano (C ₁ -C ₂ ) alkyl, -C (O) R ³¹ or C ₁ -C ₂ alkoxycarbonyl,
R ²⁴ represents a hydrogen atom or C ₁ -C ₂ alkoxycarbonyl,
R ²⁵ represents C ₁ -C ₂ alkyl or C ₁ -C ₂ haloalkyl,
R ²⁸ represents a hydrogen atom or C ₁ -C ₂ alkyl,
The substituted benzaldoxime compound or a salt thereof according to claim 8, wherein R ³¹ represents C ₁ -C ₂ alkyl, C ₁ -C ₂ haloalkyl or cyclopropyl. A ¹ represents CY,
A ⁴ represents CH,
Y represents a hydrogen atom, a halogen atom, nitro or methyl,
R ¹ represents -C (O) R ^1a or -C (O) NHR ^1c ,
R ^1a represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, cyclopropylmethyl, cyclopropyl or E-6,
R ^1c represents C ₁ -C ₃ alkyl, C ₁ -C ₃ haloalkyl, cyclopropyl or propargyl,
R ² represents a hydrogen atom, C ₁ -C ₂ alkyl, cyclopropylmethyl, C ₁ -C ₂ alkoxymethyl, cyanomethyl, allyl or propargyl,
The substituted benzaldoxime compound or a salt thereof according to claim 9, wherein R ⁴ represents a hydrogen atom, cyano or methyl.   The pest control agent which contains the 1 type (s) or 2 or more types chosen from the substituted isoxazoline compound and its salt of Claims 1-7 as an active ingredient.   An agrochemical containing one or more selected from the substituted isoxazoline compounds and salts thereof according to claim 1 as active ingredients.   A mammalian or avian internal or ectoparasite control agent comprising, as an active ingredient, one or more selected from the substituted isoxazoline compounds and salts thereof according to claim 1.   An insecticide or acaricide containing, as an active ingredient, one or more selected from the substituted isoxazoline compounds and salts thereof according to claim 1.