JP2007106756A - Substituted isoxazoline compound and pesticide - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a new pesticide, especially an insecticide or an acaricide. <P>SOLUTION: The substituted isoxazoline compound is represented by general formula (1) [A<SP>1</SP>, A<SP>2</SP>and A<SP>3</SP>are each independently a carbon atom or a nitrogen atom; G is a benzene ring or the like; X is a halogen atom, a 1-6C haloalkyl or the like; Y is a halogen atom, a 1-6C haloalkyl or the like; L is a single bond, a 1-3C alkylene chain or the like; Q is a hydrogen atom, a 1-3C haloalkyl, -C(O)N(R<SP>2</SP>)R<SP>1</SP>or the like; R<SP>1</SP>is a 1-6C alkyl, a 1-6C haloalkyl or the like; R<SP>2</SP>is a hydrogen atom, a 1-6C alkyl or the like; R<SP>3</SP>is a 1-6C haloalkyl or the like; m is an integer of 0-5; n is an integer of 0-4; r is an integer of 0-2] or its salt. The pesticide contains the same. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a novel substituted isoxazoline compound and a salt thereof, and a pest control agent comprising the compound as an active ingredient. The pest control agent in the present invention refers to the field of agriculture and horticulture or the field of livestock and hygiene (control of mammals or domestic parasites or external parasites for domestic animals and pets, and hygiene and pest control for household and commercial use. It means a pest control agent for harmful arthropods. The agrochemical in the present invention means an insecticide / acaricide, nematicide, herbicide, fungicide, etc. in the field of agriculture and horticulture.

Conventionally, for 3- (4-substituted phenyl) -4,5-dihydroisoxazole derivatives, certain 5-substituted alkyl-3,5-bis-substituted phenyl-4,5-dihydroisoxazole derivatives are pest control agents. (See, for example, Patent Document 1 and Patent Document 2). Further, 3-alkoxyphenyl-5-substituted-5-phenyl-4,5-dihydroisoxazole derivatives (see, for example, Patent Document 3), 3-alkoxyphenyl-5-substituted alkyl-5-substituted carbamoyl-4, 5-dihydroisoxazole derivatives (for example, see Patent Document 4), 3- (4-halophenyl) -5-substituted-5-substituted phenyl-4,5-dihydroisoxazole derivatives (for example, Patent Document 5 and non-patent documents) Reference 1) and 3- (4-nitrophenyl) -5-substituted-5-substituted phenyl-4,5-dihydroisoxazole derivatives (see, for example, Patent Document 2 and Non-Patent Document 2) are known. ing. However, there is no disclosure regarding 5-substituted alkyl-3,5-bis-substituted phenyl-4,5-dihydroisoxazole compounds according to the present invention, and their utility as pest control agents is completely unknown. It is not done.
International Publication No. 2005/085216 Pamphlet International Publication No. 2004/018410 Pamphlet International Publication No. 95/024398 Pamphlet International Publication No. 98/057937 Pamphlet European Patent Application No. 0455552 Synth. Commun. 2003, 33, 4163 Australian Journal of Chemistry [Australian J. Chem.] 1979, 32, 1487

  The development of pest control agents for the purpose of controlling various pests such as agricultural and horticultural pests, forest pests, and hygiene pests has progressed, and a wide variety of drugs have been put to practical use to date.

  However, due to the long-term use of such drugs, in recent years, pests have acquired drug resistance, making it difficult to control with existing insecticides and fungicides that have been used. In addition, some existing pest control agents are highly toxic, or some of them remain in the environment for a long time, and the problem of disturbing the ecosystem is becoming apparent. Under such circumstances, development of a novel pest control agent having not only high pest control activity but also low toxicity and low persistence is always expected.

  As a result of intensive studies aimed at solving the above problems, the present inventors have found that the novel substituted isoxazoline compound represented by the following general formula (1) according to the present invention has excellent pest control activity, particularly insecticide The present invention was completed by discovering that it is a very useful compound that exhibits acaricidal activity and has almost no adverse effect on non-target organisms such as mammals, fish and beneficial insects.

  That is, the present invention relates to the following [1] to [9].

  [1] General formula (1):

[Wherein, A ¹ , A ² and A ³ each independently represents a carbon atom or a nitrogen atom,
G represents a benzene ring, a nitrogen-containing 6-membered aromatic heterocycle, a furan ring, a thiophene ring or a 5-membered aromatic heterocycle containing two or more heteroatoms selected from an oxygen atom, a sulfur atom and a nitrogen atom;
X is a halogen atom, nitro, azido, -SCN, -SF _5, cyano, C ₁ -C ₆ alkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl , optionally substituted by R ⁴ (C ₃ ~C ₈₎ cycloalkyl, E1～E18, optionally substituted by C ₂ -C _{6 ^{alkenyl, R 4 (C 2 ~C 6}} ) alkenyl, C ₅ ~ C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₂ -C ₆ alkynyl, optionally substituted by R ⁴ (C ₂ ~C _{6) ^{alkynyl, -OH, -OR 5, -OSO 2}} R 5 , -SH, -S (O) _r R ⁵ , -N (R ⁷ ) R ⁶ , -N = C (R ^7a ) R ^6a , -C (O) R ⁸ , -C (R ⁸ ) = NOH, -C (R ⁸ ) = NOR ⁹ , M3, M13, M23 to M26, M28 to M30, -C (O) OR ⁹ , -C (O) SR ⁹ , -C (O) NH ₂ , -C (O ) N (R ¹⁰ ) R ⁹ , -C (S) OR ⁹ , -C (S) SR ⁹ , -C (S) NH ₂ , -C (S) N (R ¹⁰ ) R ⁹ , -SO ₂ OR ⁹ , -SO ₂ NH ₂ , -SO ₂ N (R ¹⁰ ) R ⁹ , -Si (R ^11a ) (R ^11b ) R ¹¹ , phenyl, (Z) phenyl substituted by _p1 or D1 ~ When D represents an integer of 2 or more, each X may be the same as or different from each other;
Further, when two Xs are adjacent to each other, the two adjacent Xs are -CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ O-, -CH ₂ OCH _2- , -OCH ₂ O-, -CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -CH ₂ CH ₂ N (R ¹² )-, -CH ₂ N (R ¹² ) CH _2- , -CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH _2- , -CH ₂ OCH ₂ O-, -OCH ₂ CH ₂ O-, -OCH ₂ CH ₂ S-, -CH ₂ CH = CH-,- OCH = CH-, -SCH = CH-, -N (R ¹² ) CH = CH-, -OCH = N-, -SCH = N-, -N (R ¹² ) CH = N-, -N (R ¹² By forming N = CH-, -CH = CHCH = CH-, -OCH ₂ CH = CH-, -N = CHCH = CH-, -N = CHCH = N- or -N = CHN = CH- A 5-membered ring or a 6-membered ring may be formed together with the carbon atom to which each of two Xs is bonded. At this time, the hydrogen atom bonded to each carbon atom forming the ring is optionally substituted by Z. In addition, when simultaneously substituted with two or more Z, each Z may be the same as or different from each other,
Y is a halogen atom, nitro, azido, -SCN, -SF _5, cyano, C ₁ -C ₆ alkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl , optionally substituted by R ⁴ (C ₃ ~C ₈₎ cycloalkyl, E1~E18, C ₂ ~C ₆ alkinyl, optionally substituted by R ⁴ (C ₂ ~C ₆₎ alkynyl, -OH, -OR ⁵ , -OSO ₂ R ⁵ , -SH, -S (O) _r R ⁵ , -NH ₂ , -N (R ⁷ ) R ⁶ , -N (R ⁷ ) C (O) R ^8a , -C (R ⁸ ) = NOH, -C (R ⁸ ) = NOR ⁹ , -C (O) NH ₂ , -C (O) N (R ¹⁰ ) R ⁹ , -C (S) NH ₂ , -C (S ) N (R ¹⁰ ) R ⁹ , —Si (R ^11a ) (R ^11b ) R ¹¹ , phenyl, phenyl substituted by (Z) _p1 or D1 to D38, and when n represents an integer of 2 or more, Each Y may be the same as or different from each other,
Further, when two Ys are adjacent to each other, the two adjacent Ys are —CH ₂ CH ₂ CH ₂ —, —CH ₂ CH ₂ O—, —CH ₂ OCH ₂ —, —OCH ₂ O—, —CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -SCH ₂ S-, -CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH ₂ -,- By forming CH ₂ OCH ₂ O-, -OCH ₂ CH ₂ O-, -OCH ₂ CH ₂ S-, -SCH ₂ CH ₂ S-, -OCH = N- or -SCH = N- A 5-membered ring or a 6-membered ring may be formed together with the carbon atom to which each Y is bonded, and at this time, the hydrogen atom bonded to each carbon atom forming the ring may be optionally substituted by Z Furthermore, when two or more Z are substituted at the same time, each Z may be the same as or different from each other,
L represents a single bond or a C ₁ -C ₁₂ alkylene chain,
Q represents a hydrogen atom, C ₁ -C ₆ haloalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ alkynyl, C ₂ -C ₆ haloalkynyl, -N (R ²⁾ R ¹ , -C (O) N (R ² ) R ¹ , -C (S) N (R ² ) R ¹ or R ¹³ , or when the substituent Y is present at the adjacent position, LQ Together with Y -CH ₂ CH _2- , -CH ₂ CH ₂ CH _2- , -OCH _2- , -SCH _2- , -N (R ⁶ ) CH _2- , -OCH ₂ CH _2- , -CH ₂ OCH _2- , -SCH ₂ CH _2- , -CH ₂ SCH _2- , -N (R ⁶ ) CH ₂ CH _2- , -CH ₂ N (R ⁶ ) CH _2- , -CH = CH- Alternatively, by forming —N═CH—, a 5-membered ring or a 6-membered ring may be formed together with the atoms to which LQ and Y are bonded, and at this time, bonded to each carbon atom forming the ring. hydrogen atom may be optionally substituted halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, the oxo group or thioxo group,
R ¹ is hydrogen atom, cyano, optionally substituted by C ₁ -C ₁₂ alkyl, optionally substituted by R ¹³ (C ₁ ~C ₁₂₎ alkyl, C ₃ -C ₁₂ cycloalkyl, R ¹³ ( C ₃ -C ₁₂₎ cycloalkyl, E2~E5, E8, E11~E14, E17 , C 2 ~C 12 alkenyl, optionally substituted by R ¹³ (C ₂ ~C ₁₂₎ alkenyl, C ₅ -C ₁₄ cycloalkenyl, C ₅ -C ₁₄ halo cycloalkenyl, optionally substituted by C ₃ -C _{12 ^{alkynyl, R 13 (C 3 ~C 12}} ) ^{alkynyl, -C (O) R 14,} -C (R 14) = NOH, -C (R ¹⁴ ) = NOR ¹⁵ , M3, M13, M30, -C (R ¹⁴ ) = NN (R ¹⁷ ) R ¹⁶ , -C (O) OR ¹⁵ , -C (O) SR ¹⁵ , -C (O) N (R ¹⁷ ) R ¹⁶ , -C (S) OR ¹⁵ , -C (S) SR ¹⁵ , -C (S) N (R ¹⁷ ) R ¹⁶ , -C (= NR ¹⁷ ) OR ¹⁸ , M7, M17, M23, M26, -C (= NR ¹⁷ ) SR ¹⁸ , M9, M19, M24, M28, -C (= NR ¹⁷ ) N (R ^18a ) R ¹⁸ , M11, M21, M25, M29 , -OH, -OR ¹⁵ , -SR ¹⁵ , -SO ₂ R ¹⁵ , -SO ₂ N (R ¹⁷ ) R ¹⁶ , -N (R ¹⁷ ) R ¹⁶ , -N = C (R ^17b ) R ^16b ,- C (O) ON = C ( R ^17b ) R ^16b , -SN (R ²⁰ ) R ¹⁹ , phenyl, (Z) phenyl substituted by _p1 or D1-D38,
R ² is a hydrogen atom, cyano, C ₁ -C ₁₂ alkyl, (C ₁ -C ₁₂ ) alkyl optionally substituted by R ^13a , C ₃ -C ₁₂ cycloalkyl, C ₃ -C ₁₂ halocycloalkyl, E3~E5, E11~E13, C ₃ ~C ₁₂ alkenyl, optionally substituted by R ^13a (C ₃ ~C ₁₂₎ alkenyl, C ₅ -C ₁₄ cycloalkenyl, C ₅ -C ₁₄ halo cycloalkenyl, C ₃ -C ₁₂ alkynyl, optionally substituted by R ^13a (C _{3 ~C 12)} ^{alkynyl, -C (O) R 14a,} -C (O) OR 15a, -C (O) SR 15a, -C ( O) N (R ^17a ) R ^16a , -C (S) OR ^15a , -C (S) SR ^15a , -C (O) C (O) OR ^15a , -OH, -OR ¹⁵ , -SR ¹⁵ ,- SO ₂ R ^15a , -SO ₂ N (R ^17a ) R ^16a , -N (R ¹⁷ ) R ¹⁶ , -N = C (R ^17b ) R ^16b , -SN (R ²⁰ ) R ¹⁹ , phenyl or (Z) or represents phenyl which is substituted by _p1, or, R ² together with R ¹ = C (R ^2a) and or R ² to form a R ^1a and R ¹ together C ₂ -C to form a ₇ alkylene chain , Indicates that may form a 3-8 membered ring together with the nitrogen atom to which they are attached this case the alkylene chain an oxygen atom, it may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl groups, C ₁ -C ₆ haloalkyl groups, C ₁ -C ₆ alkoxy (C ₁ -C ₆₎ alkyl groups, C ₁ -C ₆ alkoxy group, -CHO groups, C ₁ -C ₆ alkylcarbonyl groups, C ₁ -C ₆ haloalkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, C ₁ -C ₆ haloalkoxycarbonyl groups, C ₁ -C ₆ alkylaminocarbonyl group, C ₁ -C ₆ halo alkylaminocarbonyl group, a phenyl group, (Z) optionally substituted by a phenyl group, a D32 group, a D33 group, a D34 group, a D35 group, an oxo group or a thioxo group substituted by _p1 ,
R ^1a represents a hydrogen atom, —OR ¹⁵ , —SR ¹⁵ , C ₁ -C ₆ alkylsulfonyl, —NH ₂ , C ₁ -C ₆ alkylamino or di (C ₁ -C ₆ alkyl) amino,
R ^2a is C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, phenoxy, phenoxy substituted by (Z) _p1 , C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, -SCH ₂ R ^13a, C ₃ ~C ₆ alkenylthio, C ₃ -C ₆ halo alkenylene thio, C ₃ -C ₆ alkynylthio, C ₃ -C ₆ halo alkynylene ^{thio, -SC (O) R 14a,} -SC (O) OR ^15a, phenylthio, (Z) phenylthio substituted by _p1, di (C ₁ -C ₆ alkyl) or represents amino or R ^14a, or, R ^2a is C ₄ -C ₅ alkylene chain together with R ^1a Or a C _{4 to} C ₅ alkenylene chain may be formed to form a 5- to 6-membered ring with the carbon atoms to be bonded, and this alkylene chain or alkenylene chain is an oxygen atom, sulfur atom or nitrogen atoms may contain 1 to 3, and halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ Haroaruki Le group, C ₁ -C ₆ alkoxy group, C ₁ -C ₆ haloalkoxy group, C ₁ -C ₆ alkylthio group may be optionally substituted by C ₁ -C ₆ haloalkylthio group, or R ^17b group,
R ³ represents a halogen atom, cyano, optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ⁴ ( C ₃ -C ₈₎ cycloalkyl, substituted E1~E18, C ₃ ~C ₆ alkenyl, optionally substituted by R ⁴ (C ₂ ~C ₆₎ alkenyl, C ₃ -C ₆ alkynyl, optionally by R ⁴ been (C ₂ ~C ₆₎ ^{alkynyl, -OR 5, -S (O)} r R 5, -N (R 10) R 9, -C (O) R 8, -C (R 8) = NOH, -C (R ⁸ ) = NOR ⁹ , M3, M13, M30, -C (O) OR ⁹ , -C (O) SR ⁹ , -C (O) NH ₂ , -C (O) N (R ¹⁰ ) R ⁹ , -C (S) OR ⁹ , -C (S) SR ⁹ , -C (S) NH ₂ , -C (S) N (R ¹⁰ ) R ⁹ , -Si (R ^11a ) (R ^11b ) R ^{11 represents} -P (O) (OR ²¹ ) ₂ , phenyl, phenyl substituted by (Z) _p1 or D1-D38;
D1 to D38 each represent an aromatic heterocycle represented by the following structural formula;

Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkoxy (C ₁ ~ C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, -OH, C ₁ ~C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ haloalkyl sulfonyloxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ Haroaruki Sulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, -NH _2, C ₁ ~C ₆ alkyl amino, di (C ₁ -C ₆ alkyl) amino, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C _{6 haloalkoxycarbonyl, -C (O) NH 2,} C 1 ~C 6 alkyl amino carbonyl, C ₁ -C ₆ haloalkylcarbonyl aminocarbonyl, di (C ₁ -C ₆ alkyl) aminocarbonyl, -C (S _{) NH 2, -S (O)} 2 NH 2, C 1 ~C 6 alkylaminosulfonyl, di (C ₁ -C ₆ alkyl) aminosulfonyl, phenyl optionally substituted by phenyl or halogen atom, p1, when p2, p3 or p4 represents an integer of 2 or more, each Z may be the same as or different from each other;
Further, when two Zs are adjacent to each other, the two adjacent Zs are -CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ O-, -CH ₂ OCH _2- , -OCH ₂ O-, -CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -CH ₂ CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH _2- , -CH ₂ OCH ₂ O- , -OCH ₂ CH ₂ O-, -CH ₂ CH ₂ CH ₂ S-, -OCH ₂ CH ₂ S- or -CH = CH-CH = CH- may form a 5- or 6-membered ring together with the carbon atom, this time, the hydrogen atoms bonded to each carbon atom forming the ring is a halogen atom, a cyano group, a nitro group, C ₁ -C ₄ alkyl group may be optionally substituted by C ₁ -C ₄ haloalkyl groups, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio group,
E1 to E18 each represent a saturated heterocyclic ring represented by the following structural formula;

R ⁴ is a halogen atom, cyano, C _{3 to} C ₈ cycloalkyl, C _{3 to} C ₈ halocycloalkyl, E1 to E18, —OH, —OR ⁵ , —SH, —S (O) _r R ⁵ , — N (R ⁷ ) R ⁶ , -N (R ⁷ ) C (O) R ^8a , -C (O) OR ⁹ , -C (O) N (R ¹⁰ ) R ⁹ , -Si (R ^11a ) (R ^11b ) represents R ¹¹ , phenyl, (Z) phenyl substituted by _p1 or D1-D38,
R ⁵ is optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ²⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ²⁴ (C ₃ ~C ₈ ) cycloalkyl, E2~E5, E11~E14, E17, C 2 ~C 6 alkenyl, optionally substituted by R ²⁴ (C ₂ ~C ₆₎ alkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl, optionally substituted by R ²⁴ (C ₃ ~C ₆₎ alkynyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, phenyl, (Z) _represents phenyl, D1, D2, D4-D6, D8-D10, D12-D19, D21, D23, D25, D27, D30-D37 or D38 substituted by _p1 ,
R ⁶ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ ^{haloalkynyl, -C (O) R 8,} -C (O) OR 9, -C (O) SR 9, - C (O) NH ₂ , -C (O) N (R ¹⁰ ) R ⁹ , -C (S) OR ⁹ , -C (S) SR ⁹ , -C (S) NH ₂ , -C (S) N (R ¹⁰ ) R ⁹ , -C (O) C (O) R ⁹ , -C (O) C (O) OR ⁹ , -OH, -SO ₂ R ⁹ , -SO ₂ N (R ¹⁰ ) R ⁹ , -P (O) (OR ²¹ ) ₂ or -P (S) (OR ²¹ ) ₂
R ^6a represents C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₃ -C ₆ alkenyloxy, phenoxy or phenoxy substituted by (Z) _p1 ;
R ⁷ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, -CHO, C ₁ -C ₆ alkylcarbonyl, or represents C ₁ -C ₆ haloalkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl, or , R ⁷ together with R ⁶ to form a C ₂ -C ₆ alkylene chain, it is possible to form a 3- to 7-membered ring with the nitrogen atom to which R ⁷ is bonded, oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, may be optionally substituted by oxo or thioxo group,
R ^7a represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ alkenyl, phenyl or phenyl substituted by (Z) _{p 1} , or R ^7a is R ^6a Together with C ₄ -C ₆ alkylene chain to form a 5- to 7-membered ring together with the carbon atoms to which it is bonded, wherein this alkylene chain is an oxygen atom or sulfur atom 1 May contain,
R ⁸ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E 3- E5, E11~E13, C ₃ ~C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl or C ₃ -C ₆ Represents haloalkynyl,
R ^8a represents phenyl, phenyl substituted by (Z) _p1 or D1-D38,
R ⁹ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E1-E18, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, represents phenyl, phenyl or D1~D38 substituted by (Z) _p1,
R ¹⁰ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₆₎ alkyl, or represents C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl, or, R ¹⁰ is R by forming a C ₂ -C ₆ alkylene chain together with ^9, it indicates that may form a 3- to 7-membered ring together with the nitrogen atom to which they are attached this case the alkylene chain an oxygen atom, a sulfur atom or nitrogen atoms may be one comprise, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group or a C ₁ -C ₆ alkoxycarbonyl Optionally substituted by a group,
R ¹¹ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, phenyl or phenyl substituted by (Z) _p1 ;
R ^11a and R ^11b each independently represent C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₆ alkoxy;
R ¹² is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxycarbonyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ haloalkoxycarbonyl (C ₁ -C ₄₎ alkyl, phenyl (C ₁ -C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ -C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ ~ C ₆ represents alkynyl, C ₃ -C ₆ haloalkynyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, phenyl substituted by phenyl or (Z) _p1,
Further, when Z is present at the adjacent position to R ¹² is, -CH ₂ and adjacent R ¹² and _{Z CH 2 CH 2 CH 2 -} , -CH = CH-CH = CH-, -N = CH- By forming CH = CH-, -CH = N-CH = CH-, -CH = CH-N = CH- or -CH = CH-CH = N-, a 6-membered ring is formed together with the atoms to which each is bonded. it may be formed, this time, the hydrogen atoms bonded to each carbon atom forming the ring may be optionally substituted by halogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl group ,
R ¹³ is a halogen atom, nitro, cyano, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, hydroxy (C ₃ -C ₈ ) cycloalkyl, C ₁ -C ₄ alkoxy (C ₃ -C ₈₎ cycloalkyl, E1~E18, C ₅ ~C ₁₀ cycloalkyl, C ₅ -C ₁₀ halo ^{cycloalkenyl, -OR 25, -N (R 26} ) R 25, -SH, -S (O) r R 27 , -C (O) R ²⁸ , -C (R ²⁸ ) = NOH, -C (R ²⁸ ) = NOR ²⁹ , -C (O) OH, -C (O) OR ²⁹ , -C (O) SR ²⁹ , -C (O) NH ₂ , -C (O) N (R ³⁰ ) R ²⁹ , -C (O) N (R ³⁰ ) OR ²⁹ , -C (O) N (R ³⁰ ) N (R ^29a ) R ²⁹ , -C (S) OR ²⁹ , -C (S) SR ²⁹ , -C (S) NH ₂ , -C (S) N (R ³⁰ ) R ²⁹ , -C (= NR ³⁰ ) OR ³¹ , -C (= NR ³⁰ ) SR ³¹ , -C (= NR ³⁰ ) N (R ^31a ) R ³¹ , -C (= NOR ²⁹ ) N (R ^31a ) R ³¹ , -C (O) C (O) OR ²⁹ , -SO ₂ OH, -SO ₂ NH ₂ , -SO ₂ N (R ³⁰ ) R ²⁹ , -Si (R ^11a ) (R ^11b ) R ¹¹ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , M1-M30, phenyl, (Z) phenyl, naphthyl or D1-D38 substituted by _p1 And
M1 to M30 each represents a partially saturated heterocyclic ring represented by the following structural formula,

R ^13a is a halogen atom, nitro, cyano, C ₃ -C ₈ cycloalkyl, -OR ²⁵ , -N (R ²⁶ ) R ²⁵ , -S (O) _r R ²⁷ , -C (O) R ²⁸ ,- C (R ²⁸ ) = NOR ²⁹ , -C (O) OR ²⁹ , -C (O) SR ²⁹ , -C (O) NH ₂ , -C (O) N (R ³⁰ ) R ²⁹ , -C (S ) OR ²⁹ , -C (S) SR ²⁹ , -C (S) NH ₂ , -C (S) N (R ³⁰ ) R ²⁹ , -C (O) C (O) OR ²⁹ , -Si (R ^11a ) (R ^11b ) R ¹¹ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ or phenyl,
R ¹⁴ and R ^14a are each independently a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³² , C ₃ -C ₈ cycloalkyl, C ₃ -C _{8 halocycloalkyl, E3~E5, E11~E13, C 2 ~C} 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₂ -C ₆ represents alkynyl, C ₂ -C ₆ haloalkynyl, phenyl, phenyl, naphthyl or D1~D38 substituted by (Z) _p1,
R ¹⁵ and R ^15a is substituted each independently C ₁ -C ₆ alkyl, optionally substituted by R ³² (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally by R ³² and (C ₃ ~C ₈₎ cycloalkyl, E2~E5, E11~E14, E17, C 2 ~C 6 alkenyl, optionally substituted by R ³² (C ₂ ~C ₆₎ alkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl, optionally substituted by R ³² (C ₃ ~C ₆₎ alkynyl, phenyl, phenyl substituted by (Z) _p1, D1, D2, D4 to D6, D8 to D10, D12 to D19, D21, D23, D25, D27, D30 to D37 or D38,
R ¹⁶ is a hydrogen atom, C ₁ -C ₆ alkyl, optionally substituted by R ³² (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally substituted by R ³² (C ₃ -C ₈₎ cycloalkyl, E2~E5, E11~E14, E17, C 2 ~C 6 alkenyl, optionally substituted by R ³² (C ₂ ~C ₆₎ alkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl, optionally substituted by R ³² (C ₃ ~C ₆₎ ^{alkynyl, -C (O) R 28,} -C (O) OR 29, -C (O) SR ²⁹ , -C (O) NH ₂ , -C (O) N (R ³⁰ ) R ²⁹ , -C (S) R ²⁸ , -C (S) OR ²⁹ , -C (S) SR ²⁹ _{, -C (S) NH 2,} -C (S) N (R 30) R 29, -SO 2 R 29, -SO 2 NH 2, -SO 2 N (R 30) R 29, -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , phenyl, (Z) phenyl substituted by _p1 or D1-D38,
R ^16a is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E 3- E5, E11~E13, C ₂ ~C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, phenyl, phenyl substituted by (Z) _p1, D1, D2, D4 to D6, D8 to D10, D12 to D19, D21, D23, D25, D27, D30 to D37 or D38,
R ^16b is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl , C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ ~C ₄₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, substituted by (Z) _p1 phenyl (C ₁ -C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, E1～E18, phenyl (C ₂ -C ₄₎ alkenyl, di (C ₁ -C ₆ alkyl) amino, phenyl, (Z) _p1 Represents phenyl or D1-D38 substituted by
R ¹⁷ and R ^17a are each independently a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ haloalkoxy (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ haloalkylthio (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfonyl (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₆₎ alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ ~C ₄₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, -C (O) R ²⁸ , -C (O) OR ²⁹ , -C (O) SR ²⁹ , -C (S) OR ²⁹ , -C (S) SR ²⁹ , C ₁ -C ₆ alkyl or a sulfonyl or C ₁ -C ₆ haloalkylsulfonyl, or, R ¹⁷ and R ¹⁶ , R ^17a together with R ^16a each form a C ₂ -C ₆ alkylene chain to form a 3- to 7-membered ring with the nitrogen atom to which R ^17a is bonded. is an oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₄ alkoxy (C ₁ -C ₄₎ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group may be optionally substituted by C ₁ -C ₆ alkylcarbonyl group or a C ₁ -C ₆ alkoxycarbonyl group,
R ^17b represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkylthio or di (C ₁ -C ₆ alkyl) amino, or R ^{17b and} R ^16b by forming a C ₃ -C ₅ alkylene chain together, it indicates that may form a 4-6 membered ring with the carbon atoms to which they are attached this case the alkylene chain an oxygen atom, a sulfur atom or a nitrogen may contain one atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, -CHO group, by C ₁ -C ₆ alkylcarbonyl group or a C ₁ -C ₆ alkoxycarbonyl group Optionally substituted,
R ¹⁸ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C _{1 ~C 4)} alkyl, C ₁ -C ₄ alkylsulfonyl (C _{1 ~C 4)} alkyl, cyano (C _{1 ~C 6)} alkyl, C ₃ -C ₆ alkenyl or C ₃ ~ C ₆ represents alkynyl
R ^18a represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ¹⁹ is C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₁ -C ₁₂ alkoxy (C ₁ -C ₁₂ ) alkyl, cyano (C ₁ -C ₁₂ ) alkyl, C ₁ -C ₁₂ alkoxycarbonyl (C ₁ ~C ₁₂₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ halo alkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, C ₁ -C ₁₂ alkylcarbonyl, C ₁ -C ₁₂ alkoxycarbonyl, -C (O) ON = C (CH 3) SCH 3, -C (O) ON = C (SCH ₃ ) C (O) N (CH ₃ ) ₂ represents phenyl or phenyl substituted by (Z) _p1 ,
R ²⁰ is C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₁ -C ₁₂ alkoxy (C ₁ -C ₁₂ ) alkyl, cyano (C ₁ -C ₁₂ ) alkyl, C ₁ -C ₁₂ alkoxycarbonyl (C ₁ ~C ₁₂₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ halo alkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, phenyl or (Z) or represents phenyl which is substituted by _p1, or, R ²⁰ together with R ¹⁹ C ₄ ~C ₇ alkylene By forming a chain, it represents that a 5- to 8-membered ring may be formed together with the nitrogen atom to be bonded, and at this time, the alkylene chain may contain one oxygen atom or sulfur atom, and C ₁ -C may be optionally substituted by ₄ alkyl or C ₁ -C ₄ alkoxy group,
R ²¹ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ²² is a halogen atom, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ -C ₆ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ -C ₄₎ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylamino, di (C ₁ -C ₄ alkyl) amino, C ₁ ~ C ₆ alkoxycarbonyl, phenyl or phenyl substituted by (Z) _{p 1} , and when q 1 to q 8 represent an integer of 2 or more, each R ²² may be the same as or different from each other Well, furthermore, when two R ²² are substituted on the same carbon atom, the two R ²² together are oxo, thioxo, imino, C ₁ -C ₆ alkylimino, C ₁ -C ₆ alkoxy It indicates that may form an imino or C ₁ -C ₆ alkylidene,
R ²³ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C optionally substituted by R ³² ₆ haloalkenyl, C ₃ -C ₆ alkynyl, -OH, benzyloxy, -CHO, -C (O) R 33, -C (O) OR 33, -C (O) SR 33, -C (O) NHR ³⁴ , -C (O) N (R ³⁴ ) R ³³ , -C (S) NHR ³⁴ , -C (S) N (R ³⁴ ) R ³³ , -SO ₂ R ³³ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , phenyl, (Z) phenyl substituted by _p1 or D3,
R ²⁴ is halogen atom, cyano, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E1~E18, C ₁ ~C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, C ₁ -C ₆ alkylamino, di (C ₁ -C ₆ alkyl) amino, -CHO, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, C ₁ -C ₆ alkylaminocarbonyl, di (C ₁ -C ₆ alkyl) amino Represents carbonyl, phenyl, phenyl substituted by (Z) _p1 or D1-D38;
R ²⁵ is a hydrogen atom, C ₁ -C ₈ alkyl, optionally substituted by R ³² (C ₁ ~C ₈₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally substituted by R ³² (C ₃ -C ₈₎ cycloalkyl, E2~E5, E11~E14, E17, C 3 ~C 8 alkenyl, optionally substituted by R ³² (C ₃ ~C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, R ³² optionally substituted by (C ₃ ~C ₈₎ alkynyl, -CHO, -C (O) R 33, -C (O) OR 33, -C (O) SR 33, -C (O) NHR 34, -C (O) N (R ³⁴ ) R ³³ , -C (S) R ³³ , -C (S) OR ³³ , -C (S) SR ³³ , -C (S) NHR ³⁴ , -C (S) N (R ³⁴ ) R ³³ , -C (O) C (O) R ³³ , -C (O) C (O) OR ³³ , -SO ₂ R ³³ , -SO ₂ N (R ³⁴ ) R ³³ ,- Si (R ^11a ) (R ^11b ) R ¹¹ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , phenyl, (Z) phenyl substituted by _p1 , D1, D2, D4 to D6, D8 to D10, D12 to D19, D21, D23, D25, D27, D30 to D37 or D38,
R ²⁶ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, C ₁ -C ₆ alkoxy, phenyl or phenyl substituted by (Z) _{p 1} or R ²⁶ is By forming a C ₂ -C ₅ alkylene chain together with R ²⁵ , this means that a 3- to 6-membered ring may be formed together with the nitrogen atom to be bonded, and this alkylene chain is an oxygen atom, sulfur It may contain one to an atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, a phenyl group, a phenyl group substituted by (Z) _p1, also oxo group It may be substituted by a thioxo group,
R ²⁷ is optionally substituted by C ₁ -C ₈ alkyl, optionally substituted by R ³² (C ₁ ~C ₈₎ alkyl, C ₃ -C ₈ cycloalkyl, R ³² (C ₃ ~C ₈ ) cycloalkyl, E2~E5, E11~E14, E17, C 3 ~C 8 alkenyl, optionally substituted by R ³² (C ₃ -C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, optionally by R ³² substituted (C ₃ ~C ₈₎ alkynyl, -CHO, -C (O) R 33, -C (O) OR 33, -C (O) SR 33, -C (O) NHR 34, -C ( O) N (R ³⁴ ) R ³³ , -C (S) R ³³ , -C (S) OR ³³ , -C (S) SR ³³ , -C (S) NHR ³⁴ , -C (S) N (R ^{34) R 33, -C (O} ) C (O) R 33, -C (O) C (O) OR 33, -SH, C 1 ~C 6 alkylthio, C ₁ -C ₆ haloalkylthio, phenylthio, ( phenylthio substituted by _{Z) p1, -P (O)} (OR 21) 2, -P (S) (OR 21) 2, phenyl, phenyl substituted by _{(Z) p1, D9, D10} , D12, D14 ~ Represents D17, D30, D32 or D34,
R ²⁸ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ haloalkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylsulfonyl (C _{1 ~C 4)} alkyl, C ₁ -C ₆ haloalkylsulfonyl (C _{1 ~C 4)} alkyl, phenyl (C _{1 ~C 4)} alkyl, phenyl substituted by (Z) _p1 (C ₁ ~C ₄₎ represents alkyl, C ₃ -C ₆ cycloalkyl, phenyl substituted by phenyl or (Z) _p1,
R ²⁹ is optionally substituted by C ₁ -C ₈ alkyl, optionally substituted by R ³² (C ₁ ~C ₈₎ alkyl, C ₃ -C ₈ cycloalkyl, R ³² (C ₃ ~C ₈ ) cycloalkyl, E1 to E6, E11 to E14, E17, C ₂ -C ₈ alkenyl, optionally substituted by R ³² (C ₂ -C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, optionally by R ³² represents substituted (C ₃ ~C ₈₎ alkynyl, phenyl, phenyl or D1~D38 substituted by (Z) _p1,
R ³⁰ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³² , C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, or represents phenyl which is substituted by phenyl or (Z) _p1, or by R ³⁰ to form a C ₂ -C ₅ alkylene chain together with R ²⁹ Represents that a 3- to 6-membered ring may be formed together with the nitrogen atom to be bonded, in which case the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, optionally by phenyl substituted by phenyl or (Z) _p1 May be replaced,
R ³¹ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C _{1 ~C 4)} alkyl, C ₁ -C ₄ alkylsulfonyl (C _{1 ~C 4)} alkyl, cyano (C _{1 ~C 6)} alkyl, C ₃ -C ₆ alkenyl or C ₃ ~ C ₆ represents alkynyl
R ^31a represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ³² is a halogen atom, nitro, cyano, C _{3 to} C ₈ cycloalkyl, C _{3 to} C ₈ halocycloalkyl, E3, E4, E6, E7, E9, E11, E12, E14, E15, E17, C ₂ -C ₆ alkenyl, C ₂ -C ₆ ^{haloalkenyl, -OH, -OR 33, -OC (} O) R 33, -OC (O) OR 33, -OC (O) NHR 34, -OC (O) N (R ³⁴ ) R ³³ , -OC (S) NHR ³⁴ , -OC (S) N (R ³⁴ ) R ³³ , -SH, -S (O) _r R ³³ , -SC (O) R ³³ , -SC (O) OR ³³ , -SC (O) NHR ³⁴ , -SC (O) N (R ³⁴ ) R ³³ , -SC (S) NHR ³⁴ , -SC (S) N (R ³⁴ ) R ³³ , -NHR ³⁴ , -N (R ³⁴ ) R ³³ , -N (R ³⁴ ) CHO, -N (R ³⁴ ) C (O) R ³³ , -N (R ³⁴ ) C (O) OR ³³ , -N (R ³⁴ ) C (O) NHR ^33a , -N (R ³⁴ ) C (O) N (R ^33a ) R ³³ , -N (R ³⁴ ) C (S) NHR ^33a , -N (R ³⁴ ) C (S) N (R ^33a ) R ³³ , -CHO, -C (O) R ³³ , -C (O) OH, -C (O) OR ³³ , -C (O) SR ³³ , -C (O) NHR ³⁴ ,- C (O) N (R ³⁴ ) R ³³ , -C (O) C (O) OR ³³ , -Si (R ^11a ) (R ^11b ) R ¹¹ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , phenyl, phenyl substituted by (Z) _p1 or D1-D38,
R ³³ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³⁵ , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocyclo. alkyl, C ₂ -C ₆ alkenyl (C ₃ ~C ₈₎ cycloalkyl, C ₂ -C ₆ haloalkenyl (C ₃ ~C ₈₎ cycloalkyl, E3, E4, E11, E12 , C 2 ~C 8 alkenyl, C ₂ -C ₈ haloalkenyl, C ₃ -C ₈ cycloalkenyl, C ₃ -C ₈ halocycloalkyl cycloalkenyl, C ₂ -C ₈ alkynyl, C ₂ -C ₈ haloalkynyl, substituted phenyl, the (Z) _p1 Represents phenyl or D1-D38,
R ^33a and R ³⁴ are each independently a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₈ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, phenoxycarbonyl, phenoxycarbonyl substituted by (Z) _p1, phenylcarbonyl, (Z) phenylcarbonyl substituted by _p1, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, phenyl, phenyl substituted by _{(Z) p1, D1, D2} , D4~D6, D8~D10 D12-D19, D21, D23, D25, D27, D30-D37 or D38, or R ^33a and R ³⁴ together with R ³³ form a C ₂ -C ₅ alkylene chain, Forming a 3-6 membered ring with the nitrogen atom Represents good, this time the alkylene chain an oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, may be optionally substituted by a phenyl group substituted by a phenyl group or (Z) _p1,
R ³⁵ represents cyano, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, E3, E4, E11, E12 , C 1 ~C 4 alkoxy, C ₁ -C ₄ haloalkoxy, phenoxy, (Z ) _p1 phenoxy substituted by, C ₁ -C ₄ alkylthio, C ₁ -C ₄ haloalkylthio, phenylthio, (Z) phenylthio substituted by _p1, C ₁ -C ₄ alkylsulfonyl, C ₁ -C ₄ haloalkylsulfonyl , phenylsulfonyl, (Z) phenylsulfonyl substituted by ^{_{p1, -N (R 37) R}} 36, C 1 ~C 6 alkyl carbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, di ( C ₁ -C ₆ alkyl) aminocarbonyl, tri (C ₁ -C ₄ alkyl) silyl, phenyl, phenyl, naphthyl or D1~D38 substituted by (Z) _p1,
R ³⁶ is phenyl substituted by a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, phenylcarbonyl or (Z) _p1 Represents carbonyl,
R ³⁷ represents a hydrogen atom or C ₁ -C ₆ alkyl,
m represents an integer of 0 to 5;
n represents an integer of 0 to 4,
p1 represents an integer of 1 to 5,
p2 represents an integer of 0 to 4,
p3 represents an integer of 0 to 3,
p4 represents an integer of 0 to 2,
p5 represents an integer of 0 or 1,
q1 represents an integer of 0 to 3,
q2 represents an integer of 0 to 5,
q3 represents an integer of 0 to 7,
q4 represents an integer of 0 to 9,
q5 represents an integer of 0 to 6,
q6 represents an integer of 0 to 4,
q7 represents an integer of 0 to 2,
q8 represents an integer of 0 to 8,
r represents an integer of 0 to 2;
t represents an integer of 0 or 1. ]
Or a salt thereof.

[2] A ¹ represents a carbon atom or a nitrogen atom,
A ² and A ³ represent a carbon atom,
G represents a benzene ring,
X is a halogen atom, nitro, -SF _5, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ ~C ₆₎ haloalkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₆ ) Haloalkyl, C ₃ -C ₈ halocycloalkyl, —OR ⁵ , —OSO ₂ R ⁵ or —S (O) _r R ^5, and when m represents 2 or 3, each X is identical to each other. Or they may be different from each other,
Y is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, optionally substituted by R _⁴ (C ₁ ~C ⁴⁾ alkyl, -OR ^5, -SR ^5, - NH ₂ , —N (R ⁷ ) R ⁶ or —C (S) NH _2, and when n represents ₂ , each Y may be the same as or different from each other,
L represents a single bond or a C ₁ -C ₆ alkylene chain,
Q represents a hydrogen atom, C ₁ -C ₆ haloalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ ^{alkynyl, -N (R 2) R 1} , -C (O) N (R 2) R 1 or R ¹³
R ¹ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl, C ₃ -C ₆ cycloalkyl, E 3, E 4, E 11, C ₂ -C ₆ alkenyl, optionally substituted by R ¹³ ₂ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₁ -C ₆ ^{alkylcarbonyl, -CH = NOR 15, -C (} O) OR 15, -C (O) NH 2, -C (O) N (R ¹⁷ ) R ¹⁶ , -C (S) N (R ¹⁷ ) R ¹⁶ , M9, -N (R ¹⁷ ) R ¹⁶ , phenyl, phenyl substituted by (Z) _p1 , D5-D8, D10, D17 , D32-D34 or D35,
R ² is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, -CH ₂ R ^13a , C ₃ -C ₆ cycloalkyl, E3, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl , -C (O) represents R ^14a, -C (O) oR ^15a, -C a (O) C (O) oR 15a or C ₁ -C ₆ haloalkylthio,
R ³ represents C ₁ -C ₆ haloalkyl or C ₃ -C ₈ halocycloalkyl,
Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ haloalkylsulfonyloxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C _{6 alkylsulfonyl, -C (O) NH 2,} -C (S) NH 2 or -S (O ) ₂ NH ₂ and when p1, p2 or p3 represents an integer of 2 or more, each Z may be the same as or different from each other;
R ⁴ is, -OH, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ haloalkoxy, a C ₁ -C ₆ alkylthio or C ₁ -C ₆ haloalkylthio,
R ⁵ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₃ haloalkoxy (C ₁ -C ₃ ) haloalkyl,
R ⁶ is, C ₁ -C ₆ alkyl, -CHO, C ₁ ~C ₆ alkyl carbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ alkylthiocarbonyl, C ₁ -C ₆ alkoxythiocarbonyl, C ₁ -C ₆ alkyl dithio carbonyl, represents C ₁ -C ₆ alkylsulfonyl or C ₁ -C ₆ haloalkylsulfonyl,
R ⁷ represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ¹² represents a hydrogen atom, C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ¹³ is a halogen atom, cyano, C ₃ -C ₆ cycloalkyl, E3, E6, E14, -OR 25, -N (R 26) R 25, -S (O) r R 27, C 1 ~C 6 By alkylcarbonyl, -C (R ²⁸ ) = NOH, -C (R ²⁸ ) = NOR ²⁹ , -C (O) N (R ³⁰ ) R ²⁹ , -C (S) NH ₂ , phenyl, (Z) _p1 Represents substituted phenyl, D1, D5-D8, D10, D13, D16, D17, D22, D32-D34 or D35;
R ^13a represents cyano, -OR ²⁵ or -NHC (O) OR ³³ ,
R ^14a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkenyl, phenyl, (Z) represents phenyl or D32 substituted by _p1 ,
R ¹⁵ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ^15a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl, C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkenyl or C ₂ -C ₆ alkynyl,
R ¹⁶ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl, optionally substituted by R ³² , C ₃ -C ₈ cycloalkyl, C ₂ -C ₆ alkenyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, C ₁ -C ₆ haloalkylcarbonyl aminocarbonyl, phenylcarbonyl, phenyl, (Z) represents phenyl, D32, D33 or D34 substituted by _p1 ,
R ¹⁷ represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl or C ₁ -C ₆ alkylcarbonyl,
R ²² represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ²⁵ represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, -C (O) R ³³ or -C (O) OR ³³ ,
R ²⁶ represents a hydrogen atom, C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ²⁷ is, C ₁ -C ₆ represents alkyl, a C ₁ -C ₆ haloalkyl or C ₁ -C ₆ alkylcarbonyl,
R ²⁸ represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ²⁹ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl or phenyl,
R ³⁰ represents a hydrogen atom, C ₁ -C ₆ alkyl or C ₃ -C ₆ alkenyl,
R ³² represents C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkylthio, phenyl, phenyl substituted by (Z) _p1 or D32,
R ³³ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₃ -C ₆ cycloalkyl,
m represents an integer of 1 to 3,
n represents an integer of 0 to 2,
p1 represents an integer of 1 to 3,
p2 and p3 represent an integer of 0 to 2,
p4 represents an integer of 0 or 1,
q2 represents an integer of 0 to 2,
q3 and q4 represent 0,
q6 represents the integer of 0 or 1, the isoxazoline-substituted benzamide compound or a salt thereof according to the above [1].

[3] X is a halogen atom, nitro, cyano, C ₁ -C ₆ represents alkyl, C ₁ -C ₆ haloalkyl, the -OR ⁵ or -S (O) _{r R} ^5, when m is 2 or 3 Each X may be the same as or different from each other;
Y is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, -OR ^5, -SR ^5, an -NH ₂ or -N (R ⁷⁾ R ^6,
Q is substituted, hydrogen atom, C ₁ -C ₆ haloalkyl, C ₂ -C ₆ ^{alkynyl, -N (R 2) R 1} , -C (O) N (R 2) R 1, phenyl, with (Z) _p1 Represented phenyl, D10, D32 or D34,
Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, a C ₁ -C ₆ alkoxy or C ₁ -C ₆ alkylsulfonyloxy, p1 indicates an integer of 2 or more Each Z may be the same as or different from each other,
R ¹ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl,
R ² represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ³ represents C ₁ -C ₆ haloalkyl,
R ⁵ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ⁶ represents C ₁ -C ₆ alkyl, —CHO, C ₁ -C ₆ alkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl,
n represents an integer of 0 or 1,
p1 represents an integer of 1 or 2,
p2 and p3 represent an integer of 0 or 1,
The substituted isoxazoline compound or a salt thereof according to the above [2], wherein t represents 0.

[4] A ¹ represents a carbon atom,
X is a halogen atom or a C ₁ -C ₆ haloalkyl, when m is 2 or 3, each X may be the or different from each other the same as each other,
Y represents a halogen atom, C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
L represents a single bond or a C ₁ -C ₃ alkylene chain,
Q represents a hydrogen atom, C ₁ -C ₃ haloalkyl or ^{-C (O) N (R 2} ) represents R ^1,
R ¹ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ² represents a hydrogen atom,
The substituted isoxazoline compound or a salt thereof according to [3] above, wherein R ³ represents —CF ₃ or —CF ₂ Cl.

  [5] General formula (2):

[Wherein A ¹ represents a carbon atom or a nitrogen atom,
J represents a hydrogen atom or a halogen atom,
Y represents a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, the -OR ⁵ or -N (R ⁷⁾ R ^6,
L represents a single bond or a C ₁ -C ₆ alkylene chain,
Q is substituted, hydrogen atom, C ₁ -C ₆ haloalkyl, C ₂ -C ₆ alkynyl, -C (O) N (R 2) R 1, -N (R 2) R 1, phenyl, with (Z) _p1 Represented phenyl, D10, D32 or D34,
D10, D32 and D34 each represent an aromatic heterocyclic ring represented by the following structural formula,

Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, a C ₁ -C ₆ alkoxy or C ₁ -C ₆ alkylsulfonyloxy, p1 indicates an integer of 2 or more Each Z may be the same as or different from each other,
R ¹ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl,
R ² represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ³ represents C ₁ -C ₆ haloalkyl,
R ⁵ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ⁶ represents -CHO, C ₁ -C ₆ alkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl,
R ⁷ represents a hydrogen atom or C ₁ -C ₆ alkyl,
n represents an integer of 0 or 1,
p1 represents an integer of 1 or 2,
p2, p3 and p4 represent an integer of 0 or 1,
t represents 0. ]
A 4-substituted benzaldoxime compound represented by the formula:

  [6] A pest control agent containing, as an active ingredient, one or more selected from the substituted isoxazoline compounds and salts thereof described in [1] to [4] above.

  [7] An agrochemical containing one or more selected from the substituted isoxazoline compounds and salts thereof according to the above [1] to [4] as active ingredients.

  [8] A mammalian or avian internal or ectoparasite control agent comprising, as an active ingredient, one or more selected from the substituted isoxazoline compounds and salts thereof described in [1] to [4] above.

  [9] An insecticide or acaricide containing, as an active ingredient, one or more selected from the substituted isoxazoline compounds and salts thereof described in [1] to [4] above.

  The compound of the present invention has excellent insecticidal / miticidal activity against many agricultural pests, spider mites, mammals or birds' internal or ectoparasites, and has acquired resistance against existing insecticides. Even against this, it exhibits a sufficient control effect. Furthermore, it has little adverse effect on mammals, fish and beneficial insects, has low persistence, and has a light environmental impact.

  Therefore, the present invention can provide a useful novel pest control agent.

  The active compounds used as pest control agents in the present invention are the compounds represented by the above [1] to [4], and the compounds represented by the above [5] are usually used for the production of these active compounds. It is a novel production intermediate.

  The compounds encompassed by the present invention may have geometrical isomers of E-form and Z-form depending on the type of substituent, but the present invention is not limited to these E-form, Z-form or E-form. And a mixture containing the Z-form in an arbitrary ratio. In addition, the compounds included in the present invention include optically active substances resulting from the presence of one or more asymmetric carbon atoms, but the present invention includes all optically active substances or racemates.

  Among the compounds included in the present invention, those that can be converted into acid addition salts according to a conventional method include, for example, hydrohalic acids such as hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, and the like. Salt of inorganic acid such as salt, nitric acid, sulfuric acid, phosphoric acid, chloric acid, perchloric acid, salt of sulfonic acid such as methanesulfonic acid, ethanesulfonic acid, trifluoromethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, Salts of carboxylic acids such as formic acid, acetic acid, propionic acid, trifluoroacetic acid, fumaric acid, tartaric acid, succinic acid, maleic acid, malic acid, succinic acid, benzoic acid, mandelic acid, ascorbic acid, lactic acid, gluconic acid, citric acid, etc. A salt of an amino acid such as glutamic acid or aspartic acid can be used.

  Alternatively, among the compounds included in the present invention, those that can be converted into a metal salt according to a conventional method include, for example, alkali metal salts such as lithium, sodium, and potassium, and alkaline earth metals such as calcium, barium, and magnesium. It can be a salt or a salt of aluminum.

  Next, specific examples of each substituent shown in the present specification are shown below. Here, n- represents normal, i- represents iso, s- represents secondary, and t- represents tertiary, and Ph represents phenyl.

  As a halogen atom in this invention compound, a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom are mentioned. In the present specification, the notation “halo” also represents these halogen atoms.

The notation of C _{a to} C _b alkyl in the present specification represents a linear or branched hydrocarbon group having a carbon number of _a to _b , for example, methyl group, ethyl group, n-propyl group, i-propyl group, n-butyl group, i-butyl group, s-butyl group, t-butyl group, n-pentyl group, 1-methylbutyl group, 2-methylbutyl group, 3-methylbutyl group, 1-ethylpropyl group 1,1-dimethylpropyl group, 1,2-dimethylpropyl group, 2,2-dimethylpropyl group, n-hexyl group, 1-methylpentyl group, 2-methylpentyl group, 1,1-dimethylbutyl group, Specific examples include 1,3-dimethylbutyl group, heptyl group, octyl group, nonyl group, decyl group, undecyl group, dodecyl group and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, C _a -C _b haloalkyl is represented by a linear or branched chain consisting of _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. Represents a hydrocarbon group, and when substituted by two or more halogen atoms, the halogen atoms may be the same as or different from each other. For example, fluoromethyl group, chloromethyl group, bromomethyl group, iodomethyl group, difluoromethyl group, chlorofluoromethyl group, dichloromethyl group, bromofluoromethyl group, trifluoromethyl group, chlorodifluoromethyl group, dichlorofluoromethyl group, trichloromethyl Group, bromodifluoromethyl group, bromochlorofluoromethyl group, dibromofluoromethyl group, 2-fluoroethyl group, 2-chloroethyl group, 2-bromoethyl group, 2,2-difluoroethyl group, 2-chloro-2-fluoroethyl Group, 2,2-dichloroethyl group, 2-bromo-2-fluoroethyl group, 2,2,2-trifluoroethyl group, 2-chloro-2,2-difluoroethyl group, 2,2-dichloro-2 -Fluoroethyl group, 2,2,2-trichloroethyl group, 2-bromo-2,2-difluoroethyl group, 2-bromo-2-chloro-2-fluoroethyl group, 2-butyl Lomo-2,2-dichloroethyl group, 1,1,2,2-tetrafluoroethyl group, pentafluoroethyl group, 1-chloro-1,2,2,2-tetrafluoroethyl group, 2-chloro-1 1,2,2-tetrafluoroethyl group, 1,2-dichloro-1,2,2-trifluoroethyl group, 2-bromo-1,1,2,2-tetrafluoroethyl group, 2-fluoropropyl Group, 2-chloropropyl group, 2-bromopropyl group, 2-chloro-2-fluoropropyl group, 2,3-dichloropropyl group, 2-bromo-3-fluoropropyl group, 3-bromo-2-chloropropyl group Group, 2,3-dibromopropyl group, 3,3,3-trifluoropropyl group, 3-bromo-3,3-difluoropropyl group, 2,2,3,3-tetrafluoropropyl group, 2-chloro- 3,3,3-trifluoropropyl group, 2,2,3,3,3-pentafluoropropyl group, 1,1,2,3,3,3-hexafluoropropyl group, heptafluoropropyl group, 2, 3-dichloro-1,1,2,3,3-pentaph Oropropyl group, 2-fluoro-1-methylethyl group, 2-chloro-1-methylethyl group, 2-bromo-1-methylethyl group, 2,2,2-trifluoro-1- (trifluoromethyl) ethyl Groups, 1,2,2,2-tetrafluoro-1- (trifluoromethyl) ethyl group, 2,2,3,3,4,4-hexafluorobutyl group, 2,2,3,4,4, 4-hexafluorobutyl group, 2,2,3,3,4,4,4-heptafluorobutyl group, 1,1,2,2,3,3,4,4-octafluorobutyl group, nonafluorobutyl Group, 4-chloro-1,1,2,2,3,3,4,4-octafluorobutyl group, 2-fluoro-2-methylpropyl group, 2-chloro-1,1-dimethylethyl group, 2 Specific examples include -bromo-1,1-dimethylethyl group, 5-chloro-2,2,3,4,4,5,5-heptafluoropentyl group, tridecafluorohexyl group, etc. In the range of the number of carbon atoms.

In the present specification, C _{a to} C _b cycloalkyl represents a cyclic hydrocarbon group having _a to _b carbon atoms, and forms a monocyclic or complex ring structure having 3 to 6 members. I can do it. Each ring may be optionally substituted with an alkyl group within the range of the specified number of carbon atoms. For example, cyclopropyl group, 1-methylcyclopropyl group, 2-methylcyclopropyl group, 2,2-dimethylcyclopropyl group, 2,2,3,3-tetramethylcyclopropyl group, cyclobutyl group, cyclopentyl group, 2- Specific examples include methylcyclopentyl group, 3-methylcyclopentyl group, cyclohexyl group, 2-methylcyclohexyl group, 3-methylcyclohexyl group, 4-methylcyclohexyl group, bicyclo [2.2.1] heptan-2-yl group, etc. , Each selected range of carbon atoms.

In the present specification, C _a -C _b halocycloalkyl represents a cyclic hydrocarbon group composed of _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. And can form monocyclic or complex ring structures from 3 to 6-membered rings. Each ring may be optionally substituted with an alkyl group within the range of the specified number of carbon atoms, and the substitution with a halogen atom may be a ring structure part, a side chain part, They may be both, and when they are substituted by two or more halogen atoms, the halogen atoms may be the same as or different from each other. For example, 2,2-difluorocyclopropyl group, 2,2-dichlorocyclopropyl group, 2,2-dibromocyclopropyl group, 2,2-difluoro-1-methylcyclopropyl group, 2,2-dichloro-1-methyl Cyclopropyl group, 2,2-dibromo-1-methylcyclopropyl group, 2,2,3,3-tetrafluorocyclobutyl group, 2- (trifluoromethyl) cyclohexyl group, 3- (trifluoromethyl) cyclohexyl group , 4- (trifluoromethyl) cyclohexyl group and the like are listed as specific examples, and each is selected within the range of the designated number of carbon atoms.

In the present specification, C _{a to} C _b alkenyl is a linear or branched chain composed of _a to _b carbon atoms and has one or more double bonds in the molecule. Represents a saturated hydrocarbon group, for example, vinyl group, 1-propenyl group, 2-propenyl group, 1-methylethenyl group, 2-butenyl group, 1-methyl-2-propenyl group, 2-methyl-2-propenyl group, 2 -Pentenyl group, 2-methyl-2-butenyl group, 3-methyl-2-butenyl group, 2-ethyl-2-propenyl group, 1,1-dimethyl-2-propenyl group, 2-hexenyl group, 2-methyl Specific examples include 2-pentenyl group, 2,4-dimethyl-2,6-heptadienyl group, 3,7-dimethyl-2,6-octadienyl group, etc. Is done.

In the present specification, C _a -C _b haloalkenyl is a linear or branched chain consisting of _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. And an unsaturated hydrocarbon group having one or more double bonds in the molecule. At this time, when substituted with two or more halogen atoms, the halogen atoms may be the same as or different from each other. For example, 2,2-dichlorovinyl group, 2-fluoro-2-propenyl group, 2-chloro-2-propenyl group, 3-chloro-2-propenyl group, 2-bromo-2-propenyl group, 3-bromo-2 -Propenyl group, 3,3-difluoro-2-propenyl group, 2,3-dichloro-2-propenyl group, 3,3-dichloro-2-propenyl group, 2,3-dibromo-2-propenyl group, 2, 3,3-trifluoro-2-propenyl group, 2,3,3-trichloro-2-propenyl group, 1- (trifluoromethyl) ethenyl group, 3-chloro-2-butenyl group, 3-bromo-2- Butenyl group, 4,4-difluoro-3-butenyl group, 3,4,4-trifluoro-3-butenyl group, 3-chloro-4,4,4-trifluoro-2-butenyl group, 3-bromo- A 2-methyl-2-propenyl group or the like is given as a specific example, and is selected within the range of each designated number of carbon atoms.

The notation of C _a -C _b cycloalkenyl in the present specification represents a cyclic unsaturated hydrocarbon group having 1 to 2 carbon atoms and having 1 to 2 carbon atoms. A monocyclic or complex ring structure from a member ring to a 6-member ring can be formed. Each ring may be optionally substituted with an alkyl group within the range of the specified number of carbon atoms, and the double bond may be either endo- or exo-. For example, 2-cyclopenten-1-yl group, 3-cyclopenten-1-yl group, 2-cyclohexen-1-yl group, 3-cyclohexen-1-yl group, bicyclo [2.2.1] -5-hepten-2- Specific examples include yl groups and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, C _a -C _b halocycloalkenyl is a cyclic and one carbon atom having _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. Alternatively, it represents an unsaturated hydrocarbon group having two or more double bonds, and can form a monocyclic or complex ring structure having 3 to 6 members. Each ring may be optionally substituted with an alkyl group within the range of the specified number of carbon atoms, and the double bond may be either endo- or exo-. Further, the substitution by a halogen atom may be a ring structure part, a side chain part or both of them, and when substituted by two or more halogen atoms, those halogen atoms May be the same as or different from each other. For example, a 2-chlorobicyclo [2.2.1] -5-hepten-2-yl group and the like are given as specific examples, and each is selected within the range of the designated number of carbon atoms.

In the present specification, C _a -C _b alkylidene represents a linear or branched hydrocarbon group having a carbon number of _a to _b , and represents a hydrocarbon group bonded by a double bond, such as a methylidene group or an ethylidene group. Specific examples include groups, propylidene groups, 1-methylethylidene groups, butylidene groups, 1-methylpropylidene groups, pentylidene groups, 1-methylbutylidene groups, 1-ethylethylidene groups, hexylidene groups, etc. In the range of the number of carbon atoms.

In the present specification, C _a -C _b alkynyl is a linear or branched chain consisting of _a to _b carbon atoms, and has one or more triple bonds in the molecule. Represents a hydrocarbon group, for example, ethynyl group, 1-propynyl group, 2-propynyl group, 2-butynyl group, 1-methyl-2-propynyl group, 2-pentynyl group, 1-methyl-2-butynyl group, 1, Specific examples include a 1-dimethyl-2-propynyl group, a 2-hexynyl group, and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, C _a -C _b haloalkynyl represents a linear or branched chain having _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. And an unsaturated hydrocarbon group having one or more triple bonds in the molecule. At this time, when substituted by two or more halogen atoms, the halogen atoms may be the same as or different from each other. Specific examples include 2-chloroethynyl group, 2-bromoethynyl group, 2-iodoethynyl group, 3-chloro-2-propynyl group, 3-bromo-2-propynyl group, 3-iodo-2-propynyl group and the like. Each of which is selected for each specified number of carbon atoms.

The notation of C _a -C _b alkoxy in the present specification represents an alkyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methoxy group, ethoxy group, n-propyloxy group, Specific examples include i-propyloxy group, n-butyloxy group, i-butyloxy group, s-butyloxy group, t-butyloxy group, n-pentyloxy group, n-hexyloxy group, etc. It is selected in the range of the number of atoms.

The notation of C _a -C _b haloalkoxy in the present specification represents a haloalkyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a difluoromethoxy group, a trifluoromethoxy group, a chlorodifluoro Methoxy group, bromodifluoromethoxy group, 2-fluoroethoxy group, 2-chloroethoxy group, 2,2,2-trifluoroethoxy group, 1,1,2,2, -tetrafluoroethoxy group, 2-chloro-1 , 1,2-trifluoroethoxy group, 2-bromo-1,1,2-trifluoroethoxy group, pentafluoroethoxy group, 2,2-dichloro-1,1,2-trifluoroethoxy group, 2,2 , 2-trichloro-1,1-difluoroethoxy group, 2-bromo-1,1,2,2-tetrafluoroethoxy group, 2,2,3,3-tetrafluoropropyloxy group, 1,1,2, 3,3,3-hexafluoropropyloxy group, 2,2,2-trifluoro-1- (trifluoromethyl) ethoxy group, Data fluoropropyl group, 2-bromo-1,1,2,3,3,3-hexafluoro-propyloxy group, etc. As a specific example, may be selected from the range of the specified number of carbon atoms.

The notation of C _a -C _b alkenyloxy in the present specification represents an alkenyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, 2-propenyloxy group, 2-butenyloxy group, Specific examples include 2-methyl-2-propenyloxy group, 3-methyl-2-butenyloxy group and the like, and each is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylthio in the present specification represents an alkyl-S-group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylthio group, ethylthio group, n-propylthio group, i Specific examples include -propylthio group, n-butylthio group, i-butylthio group, s-butylthio group, t-butylthio group, n-pentylthio group, n-hexylthio group, etc. Selected.

The notation of C _a -C _b haloalkylthio in the present specification represents a haloalkyl-S-group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, difluoromethylthio group, trifluoromethylthio group, chlorodifluoro Methylthio group, bromodifluoromethylthio group, 2,2,2-trifluoroethylthio group, 1,1,2,2-tetrafluoroethylthio group, 2-chloro-1,1,2-trifluoroethylthio group, Pentafluoroethylthio group, 2-bromo-1,1,2,2-tetrafluoroethylthio group, 1,1,2,3,3,3-hexafluoropropylthio group, heptafluoropropylthio group, 1, Specific examples include 2,2,2-tetrafluoro-1- (trifluoromethyl) ethylthio group, nonafluorobutylthio group and the like, and each is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkenylthio in the present specification represents an alkenyl-S-group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, 2-propenylthio group, 2-butenylthio group, Specific examples include 2-methyl-2-propenylthio group, 3-methyl-2-butenylthio group and the like, and each is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b haloalkenylthio in the present specification represents a haloalkenyl-S-group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, 2-chloro-2-propenylthio group 3-chloro-2-propenylthio group, 3,3-difluoro-2-propenylthio group, 3,3-dichloro-2-propenylthio group, 2,3,3-trifluoro-2-propenylthio group, etc. Are given as specific examples and are selected within the range of each designated number of carbon atoms.

The notation of C _a -C _b alkynylthio in the present specification represents an alkynyl-S-group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as 2-propynylthio group, 2-butynylthio group, etc. Are given as specific examples and are selected within the range of each designated number of carbon atoms.

The notation of C _a -C _b haloalkynylthio in the present specification represents a haloalkynyl-S— group having the above-mentioned meaning consisting of _a to _b carbon atoms. Specific examples include 3-bromo-2-propynylthio group, 3-iodo-2-propynylthio group, and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, the notation of C _a -C _b alkylsulfinyl represents an alkyl-S (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylsulfinyl group, ethylsulfinyl group, Specific examples include n-propylsulfinyl group, i-propylsulfinyl group, n-butylsulfinyl group, i-butylsulfinyl group, s-butylsulfinyl group, t-butylsulfinyl group and the like. The range is selected.

In the present specification, the expression C _a -C _b haloalkylsulfinyl represents a haloalkyl-S (O) -group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, difluoromethylsulfinyl group, trifluoromethyl Sulfinyl group, chlorodifluoromethylsulfinyl group, bromodifluoromethylsulfinyl group, 2,2,2-trifluoroethylsulfinyl group, 2-bromo-1,1,2,2-tetrafluoroethylsulfinyl group, 1,2,2 Specific examples include 2-tetrafluoro-1- (trifluoromethyl) ethylsulfinyl group, nonafluorobutylsulfinyl group, and the like, each selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylsulfonyl in the present specification represents an alkyl-SO ₂ -group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylsulfonyl group, ethylsulfonyl group, n- Specific examples include propylsulfonyl group, i-propylsulfonyl group, n-butylsulfonyl group, i-butylsulfonyl group, s-butylsulfonyl group, t-butylsulfonyl group, n-pentylsulfonyl group, n-hexylsulfonyl group and the like. Each of which is selected for each specified number of carbon atoms.

The notation of C _a -C _b haloalkylsulfonyl in the present specification represents a haloalkyl-SO ₂ — group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a difluoromethylsulfonyl group or a trifluoromethylsulfonyl group. Chlorodifluoromethylsulfonyl group, bromodifluoromethylsulfonyl group, 2,2,2-trifluoroethylsulfonyl group, 1,1,2,2-tetrafluoroethylsulfonyl group, 2-chloro-1,1,2-trimethyl Specific examples include a fluoroethylsulfonyl group, a 2-bromo-1,1,2,2-tetrafluoroethylsulfonyl group, and the like, and each is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylamino in the present specification represents an amino group in which one of the hydrogen atoms is substituted with an alkyl group having the above meaning consisting of _a to _b carbon atoms, for example, a methylamino group , Ethylamino group, n-propylamino group, i-propylamino group, n-butylamino group, i-butylamino group, t-butylamino group and the like. Selected by range.

In the present specification, the notation of di (C _a -C _b alkyl) amino has the above-mentioned meaning that the number of carbon atoms, which may be the same or different from each other, is ab. Represents an amino group substituted by an alkyl group, for example, dimethylamino group, ethyl (methyl) amino group, diethylamino group, n-propyl (methyl) amino group, i-propyl (methyl) amino group, di (n-propyl) Specific examples include amino groups, n-butyl (methyl) amino groups, i-butyl (methyl) amino groups, t-butyl (methyl) amino groups, and the like, each selected within the range of the specified number of carbon atoms. .

The notation of C _a -C _b alkylimino in the present specification represents an alkyl-N = group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylimino group, ethylimino group, n-propylimino group. , I-propylimino group, n-butylimino group, i-butylimino group, s-butylimino group, n-pentylimino group, n-hexylimino group, etc. Selected.

In the present specification, the expression C _a -C _b alkoxyimino represents an alkoxy-N = group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a methoxyimino group, an ethoxyimino group, and n-propyl. Specific examples include oxyimino group, i-propyloxyimino group, n-butyloxyimino group, n-pentyloxyimino group, n-hexyloxyimino group, etc. Is done.

The notation of C _a -C _b alkylcarbonyl in the present specification represents an alkyl-C (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, acetyl group, propionyl group, butyryl group. Specific examples thereof include isobutyryl group, valeryl group, isovaleryl group, 2-methylbutanoyl group, pivaloyl group, hexanoyl group, heptanoyl group and the like, and each is selected in the range of the designated number of carbon atoms.

The notation of C _a -C _b haloalkylcarbonyl in the present specification represents a haloalkyl-C (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a fluoroacetyl group, a chloroacetyl group, Difluoroacetyl group, dichloroacetyl group, trifluoroacetyl group, chlorodifluoroacetyl group, bromodifluoroacetyl group, trichloroacetyl group, pentafluoropropionyl group, heptafluorobutanoyl group, 3-chloro-2,2-dimethylpropanoyl group Etc. are given as specific examples, and each is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkoxycarbonyl in the present specification represents an alkyl-OC (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a methoxycarbonyl group, an ethoxycarbonyl group, Specific examples include n-propyloxycarbonyl group, i-propyloxycarbonyl group, n-butoxycarbonyl group, i-butoxycarbonyl group, t-butoxycarbonyl group, etc., each selected within the range of the specified number of carbon atoms Is done.

The notation of C _a -C _b haloalkoxycarbonyl in the present specification represents a haloalkyl-OC (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a 2-chloroethoxycarbonyl group, Specific examples include 2,2-difluoroethoxycarbonyl group, 2,2,2-trifluoroethoxycarbonyl group, 2,2,2-trichloroethoxycarbonyl group, etc., each selected within the range of the specified number of carbon atoms Is done.

The notation of C _a -C _b alkylthiocarbonyl in the present specification represents an alkyl-SC (O) -group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylthio-C (O) -group , Ethylthio-C (O)-group, n-propylthio-C (O)-group, i-propylthio-C (O)-group, n-butylthio-C (O)-group, i-butylthio-C (O ) -Group, t-butylthio-C (O) -group and the like are listed as specific examples, and each group is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkoxythiocarbonyl in the present specification represents an alkyl-OC (S) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methoxy-C (S) — Specific examples include groups, ethoxy-C (S) -groups, n-propyloxy-C (S) -groups, i-propyloxy-C (S) -groups, etc. Selected by range.

In the present specification, the expression C _a -C _b alkyldithiocarbonyl represents an alkyl-SC (S) -group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylthio-C (S)- Group, ethylthio-C (S) -group, n-propylthio-C (S) -group, i-propylthio-C (S) -group, etc. Selected.

The notation of C _a -C _b alkylaminocarbonyl in the present specification represents a carbamoyl group in which one of the hydrogen atoms is substituted with an alkyl group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylcarbamoyl Group, ethylcarbamoyl group, n-propylcarbamoyl group, i-propylcarbamoyl group, n-butylcarbamoyl group, i-butylcarbamoyl group, s-butylcarbamoyl group, t-butylcarbamoyl group, etc. Is selected within the range of the specified number of carbon atoms.

In the present specification, the expression C _a -C _b haloalkylaminocarbonyl represents a carbamoyl group in which one of the hydrogen atoms is substituted with a haloalkyl group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as 2-fluoro Specific examples include ethylcarbamoyl group, 2-chloroethylcarbamoyl group, 2,2-difluoroethylcarbamoyl group, 2,2,2-trifluoroethylcarbamoyl group, etc., selected within the range of each specified number of carbon atoms Is done.

In the present specification, the notation of di (C _a -C _b alkyl) aminocarbonyl means in the above-mentioned meaning that the number of carbon atoms, which may be both the same or different from each other, consists of _a to _b carbon atoms. Represents a carbamoyl group substituted by an alkyl group, for example, N, N-dimethylcarbamoyl group, N-ethyl-N-methylcarbamoyl group, N, N-diethylcarbamoyl group, N, N-di-n-propylcarbamoyl group Specific examples include N, N-di-n-butylcarbamoyl group and the like, and each is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylaminosulfonyl in the present specification represents a sulfamoyl group in which one of the hydrogen atoms is substituted with an alkyl group having the above-mentioned meaning consisting of _a to _b carbon atoms. Famoyl group, ethylsulfamoyl group, n-propylsulfamoyl group, i-propylsulfamoyl group, n-butylsulfamoyl group, i-butylsulfamoyl group, s-butylsulfamoyl group, Specific examples include a t-butylsulfamoyl group and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, the notation of di (C _a -C _b alkyl) aminosulfonyl means in the above-mentioned meaning that the number of carbon atoms which may be the same or different from each other is _a to _b. Represents a sulfamoyl group substituted by an alkyl group, for example, N, N-dimethylsulfamoyl group, N-ethyl-N-methylsulfamoyl group, N, N-diethylsulfamoyl group, N, N-di- Specific examples include -n-propylsulfamoyl group, N, N-di-n-butylsulfamoyl group and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, the notation of tri (C _a -C _b alkyl) silyl is substituted by an alkyl group having the above-mentioned meaning of _a to _b carbon atoms, which may be the same or different from each other. Represents a silyl group, for example, trimethylsilyl group, triethylsilyl group, tri (n-propyl) silyl group, ethyldimethylsilyl group, n-propyldimethylsilyl group, n-butyldimethylsilyl group, i-butyldimethylsilyl group, t- Specific examples include a butyldimethylsilyl group and the like, and each butyldimethylsilyl group is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylsulfonyloxy in the present specification represents an alkylsulfonyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylsulfonyloxy group, ethylsulfonyloxy group Specific examples include an n-propylsulfonyloxy group, an i-propylsulfonyloxy group, and the like, and each is selected within the specified number of carbon atoms.

The notation of C _a -C _b haloalkylsulfonyloxy in the present specification represents a haloalkylsulfonyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, difluoromethylsulfonyloxy group, trifluoromethyl Specific examples include a sulfonyloxy group, a chlorodifluoromethylsulfonyloxy group, a bromodifluoromethylsulfonyloxy group, and the like, and each is selected within the range of the designated number of carbon atoms.

C _a -C _b cycloalkyl (C _d -C _e ) alkyl, hydroxy (C _d -C _e ) alkyl, C _a -C _b alkoxy (C _d -C _e ) alkyl, C _a -C _b herein Haloalkoxy (C _d -C _e ) alkyl, C _a -C _b alkylthio (C _d -C _e ) alkyl, C _a -C _b haloalkylthio (C _d -C _e ) alkyl, C _a -C _b alkylsulfinyl ( C _d -C _e ) alkyl, C _a -C _b haloalkylsulfinyl (C _d -C _e ) alkyl, C _a -C _b alkylsulfonyl (C _d -C _e ) alkyl, C _a -C _b haloalkylsulfonyl (C _d -C _e) alkyl, cyano (C _d ~C _e) alkyl, C _a -C _b alkoxycarbonyl (C _d ~C _e) alkyl, C _a -C _b haloalkoxycarbonyl (C _d ~C _e) alkyl, phenyl (C _d ~C _e) alkyl or (Z) _p1 notation such as phenyl (C _d ~C _e) alkyl substituted by the optional C _a -C _b are the respective meanings Black alkyl group, C _a -C _b alkoxy group, C _a -C _b haloalkoxy group, C _a -C _b alkylthio group, C _a -C _b haloalkylthio group, C _a -C _b alkylsulfinyl group, C _a ~ C _b haloalkylsulfinyl group, C _a -C _b alkylsulfonyl group, C _a -C _b haloalkylsulfonyl group, C _a -C _b alkoxycarbonyl group, C _a -C _b haloalkoxycarbonyl group, hydroxyl group, cyano group, phenyl group Or (Z) an alkyl group having the above-mentioned meaning consisting of d to e, wherein the hydrogen atom bonded to the carbon atom is optionally substituted by a phenyl group substituted by _p1 , and each designated Selected in the range of the number of carbon atoms.

Optionally substituted by R ⁴ herein (C _a ~C _b) alkyl, optionally substituted by R ¹³ (C _a ~C _b) alkyl, optionally substituted by R ^13a (C _^a ~ C _b) alkyl, optionally substituted by R ²⁴ (C _a ~C _b) alkyl, optionally substituted by R ³² (C _a ~C _b) optionally substituted by alkyl or R ³⁵ (C _a -C _b ) The notation of alkyl indicates that the number of carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted by any R ⁴ , R ¹³ , R ^13a , R ²⁴ , R ³² or R ³⁵ is a to b Represents an alkyl group having the above-mentioned meaning, and is selected in the range of each designated number of carbon atoms. At this time, when two or more substituents R ⁴ , R ¹³ , R ^13a , R ²⁴ , R ³² or R ³⁵ on each (C _a -C _b ) alkyl group are present, each R ⁴ , R ¹³ , R ^13a , R ²⁴ , R ³² or R ³⁵ may be the same as or different from each other.

In the present specification, the notation of hydroxy (C _d -C _e ) haloalkyl, C _a -C _b alkoxy (C _d -C _e ) haloalkyl or C _a -C _b haloalkoxy (C _d -C _e ) haloalkyl is as described above. The number of carbon atoms in which a hydrogen atom or a halogen atom bonded to a carbon atom is arbitrarily substituted by any C _a -C _b alkoxy group, C _a -C _b haloalkoxy group or hydroxyl group, Haloalkyl groups as defined above, each selected within a range of the specified number of carbon atoms.

As used herein, hydroxy (C _d -C _e ) cycloalkyl, C _a -C _b alkoxy (C _d -C _e ) cycloalkyl, C _a -C _b alkenyl (C _d -C _e ) cycloalkyl or C _a- The notation such as C _b haloalkenyl (C _d -C _e ) cycloalkyl is any C _a -C _b alkoxy group, C _a -C _b alkenyl group, C _a -C _b haloalkenyl group each having the above-mentioned meaning Or, a cycloalkyl group having the above-mentioned meaning consisting of d to e carbon atoms, in which a hydrogen atom bonded to a carbon atom is optionally substituted by a hydroxyl group, is selected within the range of each designated number of carbon atoms. The

Herein is optionally substituted by R ⁴ (C _a ~C _b) cycloalkyl, optionally substituted by R ¹³ (C _a ~C _b) cycloalkyl, optionally substituted by R ²⁴ (C _{a to} C _b ) cycloalkyl or (C _{a to} C _b ) cycloalkyl optionally substituted by R ³² and the like are attached to the carbon atom by any R ⁴ , R ¹³ , R ²⁴ or R ³² It represents a cycloalkyl group having the above-mentioned meaning consisting of a to b carbon atoms in which hydrogen atoms are optionally substituted, and each is selected within the range of the designated number of carbon atoms. At this time, the substitution by R ⁴ , R ¹³ , R ²⁴ or R ³² may be a ring structure part, a side chain part or both of them, and each (C _{a to} C _b ) when two or more substituents R ⁴ , R ¹³ , R ²⁴ or R ³² on the cycloalkyl group are present, each R ⁴ , R ¹³ , R ²⁴ or R ³² may be identical to each other, or They may be different from each other.

The notation of phenyl (C _a -C _b ) alkenyl in the present specification is alkenyl having the above-mentioned meaning comprising _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted by a phenyl group Represents a group and is selected for each specified number of carbon atoms.

Optionally substituted by R ⁴ herein (C _a ~C _b) alkenyl, optionally substituted by R ¹³ (C _a ~C _b) alkenyl, optionally substituted by R ^13a (C _^a ~ C _b) alkenyl, optionally substituted by R ²⁴ (C _a ~C _b) optionally substituted by alkenyl or R ³² (C _a ~C _b) representation of alkenyl, arbitrary R ^4, R ^13, R ^13a , R ²⁴ or R ³² represents an alkenyl group as defined above, wherein the number of carbon atoms is optionally substituted by hydrogen atoms bonded to carbon atoms, and each designated number of carbon atoms The range is selected. At this time, when there are two or more substituents R ⁴ , R ¹³ , R ^13a , R ²⁴ or R ³² on each (C _a -C _b ) alkenyl group, each R ⁴ , R ¹³ , R ^13a , R ²⁴ or R ³² may be the same as or different from each other.

Optionally substituted by R ⁴ herein (C _a ~C _b) alkynyl, optionally substituted by R ¹³ (C _a ~C _b) alkynyl, optionally substituted by R ¹⁶ (C _a ~ C _b) alkynyl, optionally substituted by R ^13a (C _^a ~C _b) optionally substituted by alkynyl, or R ³² (C _a ~C _b) notation alkynyl, any of R ^4, R ^13, R ^13a , R ²⁴ or R ³² represents an alkynyl group as defined above, wherein the number of carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted is a to b, each designated number of carbon atoms The range is selected. At this time, when two or more substituents R ⁴ , R ¹³ , R ^13a , R ²⁴ or R ³² on each (C _a -C _b ) alkynyl group are present, each R ⁴ , R ¹³ , R ^13a , R ²⁴ or R ³² may be the same as or different from each other.

In this specification
[R ² and R ¹ together form a C ₂ -C ₇ alkylene chain, which indicates that a 3- to 8-membered ring may be formed with the nitrogen atom to which the alkylene chain is bonded. May contain one oxygen, sulfur or nitrogen atom and may be optionally substituted with an oxo or thioxo group]
[R ⁷ represents that, together with R ⁶ , a C ₂ -C ₆ alkylene chain may be formed to form a 3- to 7-membered ring with the nitrogen atom to which the alkylene chain is bonded. May contain one oxygen, sulfur or nitrogen atom and may be optionally substituted with an oxo or thioxo group]
as well as
[R ²⁶ represents that, together with R ²⁵ , a C _{2 to} C ₅ alkylene chain may be formed to form a 3 to 6 membered ring together with the nitrogen atom to which the alkylene chain is bonded. May contain one oxygen, sulfur or nitrogen atom and may be optionally substituted with an oxo or thioxo group]
Specific examples of the notation of, 2-thione, imidazolidine, imidazolidine-2-one, imidazolidine-2-thione, piperidine, piperidin-2-one, piperidine-2-thione, 2H-3,4,5,6-tetrahydro-1,3 -Oxazin-2-one, 2H-3,4,5,6-tetrahydro-1,3-oxazine-2-thione, morpholine, 2H-3,4,5,6-tetrahydro-1,3-thiazine-2 -One, 2H-3,4,5,6-tetrahydro-1,3-thiazin-2-thione, thiomorpholine, perhydropyrimidin-2-one, piperazine, homopiperidine, homopiperidin-2-one, heptamethylene Imine, etc. The

In this specification
[R ^2a may form a C ₄ -C ₅ alkylene chain or a C ₄ -C ₅ alkenylene chain together with R ^1a to form a 5- to 6-membered ring with the carbon atoms to which R ^2a is bonded. Wherein the alkylene chain or alkenylene chain may contain 1 to 3 oxygen, sulfur or nitrogen atoms,
Specific examples of the notation include, for example, thiazolidine-2-ylidene, 2,3-dihydrothiazol-2-ylidene, imidazolidine-2-ylidene, 2,3-dihydroimidazol-2-ylidene, 2,3-dihydro-1 , 3,4-thiadiazole-2-ylidene, 1,2-dihydropyridin-2-ylidene, 2,3-dihydropyridazine-3-ylidene, 1,2-dihydropyrazine-2-ylidene, 1,2-dihydropyrimidine- 2-Ilidene, 6H-2,3-dihydro-1,3,4-thiadiazine-2-ylidene, and the like can be mentioned, and each is selected within the range of the specified number of atoms.

In this specification
[R ^7a represents that, together with R ^6a , a C ₄ -C ₆ alkylene chain may be formed to form a 5- to 7-membered ring together with the carbon atoms to be bonded. May contain one oxygen or sulfur atom,
as well as
[R ^17b represents that, together with R ^16b , a C ₃ -C ₅ alkylene chain may be formed to form a 4- to 6-membered ring with the carbon atoms to which the alkylene chain is bonded. May contain one oxygen, sulfur or nitrogen atom,
Specific examples of the notation include, for example, cyclopentylidene, tetrahydrofuran-3-ylidene, tetrahydrothiophene-3-ylidene, cyclohexylidene, tetrahydropyran-3-ylidene, tetrahydropyran-4-ylidene, tetrahydrothiopyran-3-ylidene , Tetrahydrothiopyran-4-ylidene, and the like, each selected within a range of the specified number of atoms.

In this specification
[R ¹⁰ represents that, together with R ⁹ , a C ₂ -C ₆ alkylene chain may be formed to form a 3- to 7-membered ring with the nitrogen atom to which the alkylene chain is bonded. May contain one oxygen, sulfur or nitrogen atom,
[R ¹⁷ represents that, together with R ¹⁶ , a C ₂ -C ₆ alkylene chain may be formed to form a 3- to 7-membered ring together with the atoms to be bonded. May contain one atom, sulfur atom or nitrogen atom,
[R ^17a represents that, together with R ^16a , a C ₂ -C ₆ alkylene chain may be formed to form a 3- to 7-membered ring together with the atoms to be bonded. May contain one atom, sulfur atom or nitrogen atom,
[R ²⁰ represents that, together with R ¹⁹ , a C _{4 to} C ₇ alkylene chain may be formed to form a 5- to 8-membered ring together with the nitrogen atom to which the alkylene chain is bonded. May contain one oxygen or sulfur atom,
[R ³⁰ represents that, together with R ²⁹ , a C _{2 to} C ₅ alkylene chain may be formed to form a 3- to 6-membered ring with the nitrogen atom to be bonded. May contain one oxygen, sulfur or nitrogen atom,
[R ^33a represents that, together with R ³³ , a C ₂ -C ₅ alkylene chain may be formed to form a 3- to 6-membered ring with the nitrogen atom to which it is bonded. May contain one oxygen, sulfur or nitrogen atom,
as well as
[R ³⁴ represents that, together with R ³³ , a C _{2 to} C ₅ alkylene chain may be formed to form a 3- to 6-membered ring with the nitrogen atom to which the R ³⁴ is bonded, May contain one oxygen, sulfur or nitrogen atom,
Specific examples of the notation include, for example, aziridine, azetidine, pyrrolidine, oxazolidine, thiazolidine, imidazolidine, piperidine, morpholine, thiomorpholine, piperazine, homopiperidine, heptamethyleneimine, etc. Selected.

In the compounds included in the present invention, examples of combinations of atoms represented by A ¹ , A ² and A ³ include the following groups.

That is, AI: A ¹ , A ² and A ³ are carbon atoms.

A-II: A ¹ is a nitrogen atom, A ² and A ³ are carbon atoms.

A-III: A ² is a nitrogen atom, and A ¹ and A ³ are carbon atoms.

A-IV: A ¹ and A ³ are nitrogen atoms, and A ² is a carbon atom.

AV: A ¹ and A ² are nitrogen atoms, and A ³ is a carbon atom.

A-VI: A ² and A ³ are nitrogen atoms, and A ¹ is a carbon atom.

  In the compounds included in the present invention, examples of the substituent represented by G include aromatic 6-membered rings such as phenyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl and furyl, thienyl, isoxazolyl, isothiazolyl, pyrazolyl, oxazolyl, thiazolyl, Examples include 5-membered aromatic rings such as imidazolyl, and among these, phenyl, pyridyl, thienyl, pyrazolyl and thiazolyl are preferable, and phenyl is particularly preferable.

  In the compounds included in the present invention, examples of the range of the substituent represented by X include the following groups. At this time, when m represents an integer of 2 or more in each of the following cases, each X may be the same as or different from each other.

  That is, X-I: a halogen atom.

X-II: halogen atom and C ₁ -C ₆ haloalkyl.

X-III: halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, —OR ⁵ and —S (O) _r R ⁵ [where R ⁵ is C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl, r is an integer of 0 to 2. ].

X-IV: halogen atom, nitro, -SF _5, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ ~C ₆₎ haloalkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₆₎ haloalkyl, C ₃ -C ₈ halocycloalkyl, -OR ^5, -OSO ₂ R ⁵ and -S (O) _{r R} ⁵ [wherein, R ⁵ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₃ haloalkoxy (C ₁ ~C ₃₎ haloalkyl, r is an integer of 0 to 2. ].

  In the compound included in the present invention, m representing the number of substituents represented by X includes an integer of 0 to 5, and among these, m is preferably 1, 2 or 3.

  In the compounds included in the present invention, examples of the range of the substituent represented by Y include the following groups. At this time, when n represents an integer of 2 or more in each of the following cases, each Y may be the same as or different from each other.

That, YI: C ₁ ~C ₆ alkyl.

Y-II: halogen atom, C ₁ -C ₆ alkyl and C ₁ -C ₆ haloalkyl.

Y-III: halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, -OR ^5, -SR ⁵ [wherein, R ⁵ is C ₁ -C ₆ alkyl or C ₁ -C Represents ₆ haloalkyl. ], - NH ₂ and -N (R ⁷⁾ R ⁶ [wherein, R ⁶ is C ₁ -C ₆ represents alkyl, -CHO, a C ₁ -C ₆ alkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl, R ⁷ represents a hydrogen atom or a C ₁ -C ₆ alkyl. ].

Y-IV: halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, optionally substituted by R _⁴ (C ₁ ~C ⁴⁾ alkyl [wherein, R ⁴ is -OH represents C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, a C ₁ -C ₆ alkylthio or C ₁ -C ₆ haloalkylthio. ^{], - OR 5, -SR 5} [ wherein, R ⁵ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl. _{], - NH 2, -N (} R 7) R 6 [ wherein, R ⁶ is C ₁ -C ₆ alkyl, -CHO, C ₁ ~C ₆ alkyl carbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ ~ C ₆ alkoxycarbonyl, C ₁ -C ₆ alkylthiocarbonyl, C ₁ -C ₆ alkoxythiocarbonyl, C ₁ -C ₆ alkyl dithio carbonyl, C ₁ -C ₆ alkyl sulfonyl or C ₁ -C ₆ haloalkylsulfonyl, R ⁷ represents a hydrogen atom or a C ₁ -C ₆ alkyl. ] And -C (S) NH _2.

  In the compound included in the present invention, n representing the number of substituents represented by Y includes an integer of 0 to 4, and among these, n is preferably 0 or 1.

  In the compounds included in the present invention, examples of the range of the substituent represented by L include the following groups.

  That is, L-I: single bond.

L-II: C ₁ -C ₃ alkylene chain [where C ₁ -C ₃ alkylene chain represents methylene, ethylidene, 1-methylethylidene, or the like. ].

L-III: C ₁ -C ₆ alkylene chain [where C ₁ -C ₆ alkylene chain means methylene, ethylidene, propylidene, 1-methylethylidene, butylidene, 1-methylpropylidene, 2-methylpropylidene, pentylidene 1-methylbutylidene, 2-methylbutylidene, 3-methylbutylidene, hexylidene, ethylene, trimethylene, tetramethylene, pentamethylene, hexamethylene and the like. ].

  In the compound included in the present invention, examples of the range of the substituent represented by Q include the following groups.

That, QI: C ₁ ~C ₃ haloalkyl.

Q-II: hydrogen atom and —C (O) N (R ² ) R ¹ [wherein R ¹ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl, and R ² represents a hydrogen atom. ].

Q-III: C ₁ -C ₆ haloalkyl, C ₂ -C ₆ alkynyl, -C (O) N (R ² ) R ¹ [where R ¹ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl, R ² represents a hydrogen atom or C ₁ -C ₆ alkyl. ], Phenyl, phenyl substituted by (Z) _p1, D10, D32 and D34 [wherein, Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C _{6 represents} alkoxy or C ₁ -C ₆ alkylsulfonyloxy, and when p1 represents an integer of 2 or more, each Z may be the same as or different from each other, and p1 is an integer of 1 or 2 P2 and p3 represent an integer of 0 or 1, and t represents 0. ].

^{Q-IV: -N (R 2} ) R 1 [ wherein, R ¹ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl, R ² represents a hydrogen atom or a C ₁ -C ₆ alkyl. ].

QV: hydrogen atom, —C (O) N (R ² ) R ¹ [where R ¹ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C _{It represents 6} alkenyl or C ₃ -C ₆ alkynyl, and R ² represents a hydrogen atom or C ₁ -C ₆ alkyl. ], Phenyl, phenyl substituted by (Z) _p1, D10, D32 and D34 [wherein, Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C _{6 represents} alkoxy or C ₁ -C ₆ alkylsulfonyloxy, and when p1 represents an integer of 2 or more, each Z may be the same as or different from each other, and p1 is an integer of 1 or 2 P2 and p3 represent an integer of 0 or 1, and t represents 0. ].

Q-VI: hydrogen atom, C ₁ -C ₆ haloalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, -C (O) N (R ² ) R ¹ [where R ¹ is C _1- C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl represents R ² represents a hydrogen atom or C ₁ -C ₆ alkyl. And R ¹³ wherein R ¹³ is cyano, C ₃ -C ₆ cycloalkyl, E 3, C ₁ -C ₆ alkylcarbonyl, —C (S) NH ₂ , phenyl, phenyl substituted by (Z) _{p 1} , D10, D16, D17, represents D32~D34 or D35, Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ haloalkylsulfonyloxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, -C (O) NH ₂ , —C (S) NH ₂ or —S (O) ₂ NH _2, and when p1, p2 or p3 represents an integer of 2 or more, each Z may be the same or different from each other P1 represents an integer of 1 to 3, p2 and p3 represent an integer of 0 to 2, p4 and p5 represent an integer of 0 or 1, q3 represents 0, and t represents 0 or 1 Adjustment A representative. ].

Q-VII: a hydrogen atom and —C (O) N (R ² ) R ¹ [wherein R ¹ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted with R ¹³ , C ₃ -C ₆ cycloalkyl, E3, E4, E11, C 2 ~C 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₁ -C ₆ alkylcarbonyl, -CH = NOR ^15, -C (O) OR ¹⁵ , -C (O) NH ₂ , -C (O) N (R ¹⁷ ) R ¹⁶ , -C (S) N (R ¹⁷ ) R ¹⁶ , M9, -N (R ¹⁷ ) phenyl R ^16, phenyl, substituted by _{(Z) p1, D5~D8, D10} , D17, represents D32~D34 or D35, R ² is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl _{^{, -CH 2 R 13a, C 3}} ~C 6 cycloalkyl, E3, C ₃ ~C ₆ alkenyl, C ₃ -C ₆ ^{alkynyl, -C (O) R 14a,} -C (O) OR 15a, -C ( O) C (O) OR ^15a or C ₁ -C ₆ haloalkylthio, R ¹² represents a hydrogen atom, C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl, R ¹³ represents a halogen atom, cyano, C ₃ -C ₆ cycloalkyl , E3, E6, E14, -OR 25, -N (R 26) R 25, -S (O) r R 27, C 1 ~C 6 alkyl ^{carbonyl, -C (R 28) = NOH} , -C (R ²⁸ ) = NOR ²⁹ , -C (O) N (R ³⁰ ) R ²⁹ , -C (S) NH ₂ , phenyl, phenyl substituted by (Z) _p1 , D1, D5-D8, D10, D13, D16 , D17, D22, represents D32~D34 or D35, R ^13a represents cyano, -OR ²⁵ or ^{-NHC (O) oR 33, R} 14a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C _{1 ~C 4)} alkyl, C ₁ -C ₄ alkylthio (C _{1 ~C 4)} alkyl, C ₁ -C ₄ alkylsulfinyl (C _{1 ~C 4)} alkyl, C ₁ -C ₄ represents alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkenyl, phenyl, phenyl or D32 substituted by (Z) _p1, R ¹⁵ is C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl, R ^15a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ Al Le, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkenyl or C ₂ -C ₆ alkynyl, R ¹⁶ is C ₁ -C ₆ alkyl , C ₁ -C ₆ haloalkyl, optionally substituted by R ³² (C ₁ ~C ₄₎ alkyl, C ₃ -C ₈ cycloalkyl, C ₂ -C ₆ alkenyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, C ₁ -C ₆ haloalkylcarbonyl aminocarbonyl, phenylcarbonyl, phenyl, phenyl substituted by (Z) _p1, D32, D33 Or D34, R ¹⁷ represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl or C ₁ -C ₆ alkylcarbonyl, and R ²² represents C ₁ -C _4. alkyl or C ₁ -C ₄ haloalkyl, R ²⁵ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, represents -C (O) R ³³ or -C (O) OR ³³ , R ²⁶ represents a hydrogen atom, C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl, and R ²⁷ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₆ alkylcarbonyl, R ²⁸ represents a hydrogen atom or C ₁ -C ₆ alkyl, R ²⁹ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl or phenyl, R ³⁰ represents a hydrogen atom, C ₁ -C ₆ alkyl or C ₃ -C ₆ alkenyl, R ³² represents C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkylthio, phenyl, phenyl substituted by (Z) _{p 1 or} D ³² and R ³³ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₃ -C ₆ cycloalkyl, Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ Haroa Kokishi, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ haloalkylsulfonyloxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, -C (O) NH ₂ , -C (S) NH ₂ or -S (O) ₂ NH _2, and when p1, p2 or p3 represents an integer of 2 or more, each Z may be the same as or different from each other P1 represents an integer of 1 to 3, p2 and p3 represent an integer of 0 to 2, p4 and p5 represent an integer of 0 or 1, q2 represents an integer of 0 to 2, q3 and q4 Represents 0, q6 represents an integer of 0 or 1, r represents an integer of 0 to 2, and t represents an integer of 0 or 1. ].

Q-VIII: hydrogen atom and R ¹³ [where R ¹³ is cyano, C ₃ -C ₆ cycloalkyl, E 3, E 6, E 14, —OR ²⁵ , —N (R ²⁶ ) R ²⁵ , —S (O) _{r R} ^27, C _{1 ~C 6} alkyl ^{carbonyl, -C (R 28) = NOH} , -C (R 28) = NOR 29, -C (O) N (R 30) R 29, -C (S) NH ₂ , phenyl, phenyl substituted by (Z) _p1 , D1, D5-D8, D10, D13, D16, D17, D22, D32-D34 or D35, R ¹² is a hydrogen atom, C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl, R ²² represents a C ₁ -C ₄ alkyl, R ²⁵ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, -C (O) R ^33, or represents ^{-C (O) oR 33, R} 26 represents a hydrogen atom, C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl, R ²⁷ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C represents ₁ -C ₆ alkylcarbonyl, R ²⁸ represents a hydrogen atom or a C ₁ -C ₆ alkyl, R ²⁹ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl Alkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl or phenyl, R ³⁰ represents a hydrogen atom, C ₁ -C ₆ alkyl or C ₃ -C ₆ alkenyl, R ³³ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₃ -C ₆ cycloalkyl, Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ haloalkylsulfonyloxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, -C (O) NH ₂ , —C (S) NH ₂ or —S (O) ₂ NH _2, and when p1, p2 or p3 represents an integer of 2 or more, each Z may be the same or They may be different from each other, p1 represents an integer of 1 to 3, p2 and p3 represent an integer of 0 to 2, p4 and p5 represent an integer of 0 or 1, q 2 represents an integer of 0 to 2, q3 represents 0, r represents an integer of 0 to 2, and t represents an integer of 0 or 1. ].

In the compounds included in the present invention, examples of the range of the substituent represented by R ³ include the following groups.

That is, R ³ -I: —CF ₃ and —CF ₂ Cl.

R ³ -II: —CHF ₂ , —CF ₃ , —CF ₂ Cl, —CF ₂ Br, —CF ₂ CHF ₂ and —CF ₂ CF ₃ .

R ³ -III: C ₁ -C ₆ alkyl optionally substituted with two or more optional halogen atoms.

R ³ -IV: C ₁ -C ₆ haloalkyl.

R ³ -V: C ₁ -C ₆ haloalkyl and C ₃ -C ₈ halocycloalkyl.

R ³ -VI: C ₁ ~C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ haloalkyl, C ₁ -C ₄ haloalkoxy (C ₁ ~C ₄₎ haloalkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄₎ haloalkyl, C ₁ -C ₄ haloalkylthio (C ₁ -C ₄₎ haloalkyl, cyano (C ₁ -C ₆₎ haloalkyl, C ₃ -C ₆ cycloalkyl and C _{3 ~C 8} halocycloalkyl.

Each group which shows the range of each substituent in these compounds included in the present invention can be arbitrarily combined, and each represents the range of the present compound. Examples of combinations of ranges for X, Y, L and Q include, for example, combinations shown in Table 1 below. However, the combinations in Table 1 are for illustrative purposes, and the present invention is not limited to these.
Table 1 Table 1 (continued)
―――――――――――――――――――――――――――――――――――――――
XYLQXYLQ
―――――――――――――――――――――――――――――――――――――――
XI YI LI QI X-II YI L-III Q-VIII
XI YI LI Q-III X-II Y-II LI QI
XI YI LI Q-IV X-II Y-II LI Q-III
XI YI LI Q-VI X-II Y-II LI Q-IV
XI YI L-II Q-II X-II Y-II LI Q-VI
XI YI L-II QV X-II Y-II L-II Q-II
XI YI L-II Q-VII X-II Y-II L-II QV
XI YI L-II Q-VIII X-II Y-II L-II Q-VII
XI YI L-III Q-II X-II Y-II L-II Q-VIII
XI YI L-III QV X-II Y-II L-III Q-II
XI YI L-III Q-VII X-II Y-II L-III QV
XI YI L-III Q-VIII X-II Y-II L-III Q-VII
XI Y-II LI QI X-II Y-II L-III Q-VIII
XI Y-II LI Q-III X-II Y-III LI QI
XI Y-II LI Q-IV X-II Y-III LI Q-III
XI Y-II LI Q-VI X-II Y-III LI Q-IV
XI Y-II L-II Q-II X-II Y-III L-II Q-II
XI Y-II L-II QV X-II Y-III L-II QV
XI Y-II L-II Q-VII X-II Y-IV LI QI
XI Y-II L-II Q-VIII X-II Y-IV L-II Q-II
XI Y-II L-III Q-II X-III YI LI QI
XI Y-II L-III QV X-III YI LI Q-III
XI Y-II L-III Q-VII X-III YI LI Q-IV
XI Y-II L-III Q-VIII X-III YI L-II Q-II
XI Y-III LI QI X-III YI L-II QV
XI Y-III LI Q-III X-III Y-II LI QI
XI Y-III LI Q-IV X-III Y-II LI Q-III
XI Y-III L-II Q-II X-III Y-II LI Q-IV
XI Y-III L-II QV X-III Y-II L-II Q-II
XI Y-IV LI QI X-III Y-II L-II QV
XI Y-IV L-II Q-II X-III Y-III LI QI
X-II YI LI QI X-III Y-III L-II Q-II
X-II YI LI Q-III X-III Y-IV LI QI
X-II YI LI Q-IV X-III Y-IV L-II Q-II
X-II YI LI Q-VI X-IV YI LI QI
X-II YI L-II Q-II X-IV YI L-II Q-II
X-II YI L-II QV X-IV Y-II LI QI
X-II YI L-II Q-VII X-IV Y-II L-II Q-II
X-II YI L-II Q-VIII X-IV Y-III LI QI
X-II YI L-III Q-II X-IV Y-III L-II Q-II
X-II YI L-III QV X-IV Y-IV LI QI
X-II YI L-III Q-VII X-IV Y-IV L-II Q-II
―――――――――――――――――――――――――――――――――――――――
The compound of the present invention can be produced, for example, by the following method.

  Manufacturing method A

General formula (3) [wherein A ¹ , A ² , A ³ , G, X, Y, R ³ , m and n represent the same meaning as described above, and J ¹ represents a halogen atom. And a compound represented by the general formula (4): wherein L and Q are as defined above. Or a alkali metal salt thereof, if necessary, using a solvent inert to the reaction, if necessary in the presence of a base, and if necessary in the presence of a suitable catalyst. In general formula (1-1), r is 0 in general formula (1-1) [wherein A ¹ , A ² , A ³ , G, X, Y, L, Q, R ³ , m and n represents the same meaning as described above. This invention compound represented by this can be obtained.

  The amount of the reaction substrate may be 1 to 100 equivalents of the compound represented by the general formula (4) with respect to 1 equivalent of the compound represented by the general formula (3).

  In the case of using a solvent, the solvent to be used is not particularly limited as long as it does not inhibit the progress of the reaction. For example, aromatic hydrocarbons such as benzene, toluene and xylene, and aliphatic hydrocarbons such as hexane and heptane. , Cycloaliphatic hydrocarbons, chlorobenzene, dichlorobenzene and other aromatic halogenated hydrocarbons, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, 1,1,1-trichloroethane, trichloroethylene, tetrachloroethylene Aliphatic hydrocarbons such as ethylene glycol, diethylene glycol and the like, ethers such as diethyl ether, 1,2-dimethoxyethane, tetrahydrofuran, 1,4-dioxane, N, N-dimethylformamide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone, etc. Amides, pyridine, pyridine picoline, etc., acetonitrile, dimethylsulfoxide, hexamethylphosphoric triamide, and water, and the like. These solvents may be used alone or as a mixture of two or more thereof.

  When a base is used, for example, alkali metal hydrides such as sodium hydride and potassium hydride, alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, alkali metal alkoxides such as sodium ethoxide and potassium t-butoxide Alkali metal carbonates such as sodium carbonate and potassium carbonate, alkali metal bicarbonates such as sodium hydrogen carbonate and potassium hydrogen carbonate, triethylamine, tributylamine, N, N-dimethylaniline, pyridine, 4- (dimethylamino) pyridine, An organic base such as imidazole and 1,8-diazabicyclo [5,4,0] -7-undecene can be used in an amount of 1 to 5 equivalents with respect to the compound represented by the general formula (3).

  In the case of using a catalyst, for example, a quaternary amine salt such as tetrabutylammonium chloride or tetrabutylammonium bromide, a crown ether such as 18-Crown-6, or the like is 0.001 to the compound represented by the general formula (3). 0.5 equivalent can be used.

  The reaction temperature can be set to an arbitrary temperature from −60 ° C. to the reflux temperature of the reaction mixture, and the reaction time varies depending on the concentration of the reaction substrate and the reaction temperature, but is usually arbitrarily within the range of 5 minutes to 100 hours. Can be set.

  In general, for example, 1 to 3 equivalents of the compound represented by the general formula (4) per 1 equivalent of the compound represented by the general formula (3), if necessary, 1 to 2 equivalents of potassium hydroxide, In the presence of a base such as potassium-t-butoxide and potassium carbonate, using a solvent such as tetrahydrofuran, N, N-dimethylformamide, N-methyl-2-pyrrolidone, dimethyl sulfoxide and the like in a temperature range of 0 to 100 ° C., The reaction is carried out for 1 to 18 hours, or 1.05 to 1.5 equivalents of an alkali metal salt of the compound represented by the general formula (4) per 1 equivalent of the compound represented by the general formula (3). In the presence of 0.01 to 0.2 equivalents of a phase transfer catalyst such as tetrabutylammonium chloride and tetrabutylammonium bromide, a two-layer system of an organic solvent such as toluene and chlorobenzene and water is used. In the range of reflux temperature, It is preferable to carry out the reaction for 1 to 4 hours.

  Manufacturing method B

General formula (3) [wherein A ¹ , A ² , A ³ , G, X, Y, R ³ , m, n and J ¹ represent the same meaning as described above. ], An alkali metal sulfide such as sodium sulfide and sodium hydrosulfide and hydrates thereof, or a thiol such as alkylthiol and thioglycolic acid, and an inert gas atmosphere such as nitrogen and argon, If necessary, a solvent inert to the reaction is used, and if necessary, in the presence of a base, the reaction is carried out, so that in general formula (1), L represents a single bond, Q is a hydrogen atom, and r is General formula (1-2) which is 0 [wherein A ¹ , A ² , A ³ , G, X, Y, R ³ , m and n represent the same meaning as described above. This invention compound represented by this can be obtained.

  For the amount of the reaction substrate, 1 to 10 equivalents of alkali metal sulfide or thiol can be used with respect to 1 equivalent of the compound represented by the general formula (3).

  In the case of using a solvent, the solvent used is not particularly limited as long as it does not inhibit the progress of the reaction, but for example, aromatic hydrocarbons such as benzene, toluene, xylene, methanol, ethanol, ethylene glycol, diethylene glycol, etc. Examples include alcohols, amides such as N, N-dimethylformamide, N, N-dimethylacetamide, and N-methyl-2-pyrrolidone, pyridines such as pyridine and picoline, acetonitrile, dimethyl sulfoxide, and sulfolane. These solvents may be used alone or as a mixture of two or more thereof.

  When using a base, for example, alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, alkali metal carbonates such as sodium carbonate and potassium carbonate, alkali metal bicarbonates such as sodium bicarbonate and potassium bicarbonate, etc. 1-20 equivalent can be used with respect to 1 equivalent of compounds represented by General formula (3).

  The reaction temperature can be set to any temperature from room temperature to the reflux temperature of the reaction mixture, and the reaction time varies depending on the concentration of the reaction substrate and the reaction temperature, but can usually be arbitrarily set in the range of 30 minutes to 100 hours. .

  In general, for example, 1 to 3 equivalents of sodium sulfide, sodium hydrosulfide and the like are used for 1 equivalent of the compound represented by the general formula (3), and in a solvent such as N-methyl-2-pyrrolidone, 120 to After reacting in the temperature range of 180 ° C. for 1 to 15 hours, neutralize by adding an acid such as acetic acid, hydrochloric acid, sulfuric acid, phosphoric acid, or 1 equivalent of the compound represented by the general formula (3) 2 to 4 equivalents of alkylthiol, thioglycolic acid and the like, and if necessary, in the presence of 3 to 12 equivalents of a base such as sodium hydroxide or potassium hydroxide, N, N-dimethylformamide, N, A reaction such as N-dimethylacetamide, N-methyl-2-pyrrolidone, toluene-ethylene glycol and the like is carried out at 120 to 180 ° C. for 1 to 24 hours, and then acetic acid, hydrochloric acid, sulfuric acid, phosphoric acid. It is preferable to add an acid such as .

  In addition, the compound represented by the general formula (3) and thiourea are used in an inert gas atmosphere such as nitrogen or argon, and if necessary, using a solvent inert to the reaction, in the presence of a transition metal catalyst. The compound of the present invention represented by the general formula (1-2) can also be synthesized by hydrolyzing the isothiuronium salt intermediate produced by the reaction.

  As the amount of the reaction substrate, 1 to 3 equivalents of thiourea can be used per 1 equivalent of the compound represented by the general formula (3).

  When a solvent is used, the solvent used is not particularly limited as long as it does not inhibit the progress of the reaction. For example, N, N-dimethylformamide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone, etc. Examples include amides, ethers such as diethyl ether, 1,2-dimethoxyethane, tetrahydrofuran and 1,4-dioxane, ketones such as acetone and methyl ethyl ketone, acetonitrile, and hexamethylphosphoric triamide. These solvents may be used alone or as a mixture of two or more thereof.

  As the catalyst, for example, a zero-valent transition metal catalyst such as nickel can be used in an amount of 0.005 to 0.5 equivalent relative to 1 equivalent of the compound represented by the general formula (3).

  The reaction temperature can be set to any temperature from room temperature to the reflux temperature of the reaction mixture, and the reaction time varies depending on the concentration of the reaction substrate and the reaction temperature, but can usually be arbitrarily set in the range of 30 minutes to 100 hours. .

  In general, for example, 1 to 1.5 equivalents of thiourea is used per 1 equivalent of the compound represented by the general formula (3), and 0.01 to 0.03 equivalents of dichlorobis (triethylphosphine) nickel (II). ) And sodium borohydride prepared in the system in the presence of a zerovalent nickel catalyst in an organic solvent such as 1,4-dioxane, N, N-dimethylformamide, acetonitrile and the like at a temperature range of 40 to 100 ° C. The intermediate isothiuronium salt produced by performing the reaction for 8 hours is used in a solvent such as a benzene-water mixture in a temperature range from room temperature to 100 ° C. using a base such as sodium hydroxide or potassium hydroxide for 10 minutes to After performing the hydrolysis reaction for 2 hours, it is preferable to neutralize by adding an acid such as acetic acid, hydrochloric acid, sulfuric acid or phosphoric acid.

The compound of the present invention represented by the general formula (1-2) obtained as described above was subjected to the general formula (5) under the same conditions as in Production Method A, wherein L and Q are other than hydrogen atoms. J ² represents a chlorine atom, a bromine atom, an iodine atom, a C ₁ -C ₄ haloalkylsulfonate group (eg, trifluoromethanesulfonyloxy group) or an azolyl group (eg, imidazol-1-yl group). Such a good leaving group is represented. And a compound represented by the general formula (1-1) wherein r is 0 in the general formula (1), wherein A ¹ , A ² , A ³ , G, X, Y, L, Q, R ³ , m and n have the same meaning as described above. This invention compound represented by this can be obtained.

  Manufacturing method C

In the general formula (1), r is 0, and the general formula (1-1) [wherein A ¹ , A ² , A ³ , G, X, Y, L, Q, R ³ , m and n are as defined above] Represents the same meaning. The compound of the present invention represented by the formula (1) is used in a solvent inert to the reaction, if necessary, in the presence of a base, if necessary, using a suitable catalyst, and a general sulfide oxidizing agent. In the general formula (1-3), r is 1 in the general formula (1-3) [wherein A ¹ , A ² , A ³ , G, X, Y, L, Q, R ³ , m and n have the same meaning as described above. This invention compound represented by this can be obtained.

  The oxidizing agent is not particularly limited as long as it is used for oxidation of ordinary sulfides. For example, simple halogens such as chlorine gas and bromine, N-halosuccinic acid such as N-chlorosuccinimide, N-bromosuccinimide and the like. Organic peroxides such as imides, peracetic acid, 3-chloroperbenzoic acid, hydrogen peroxide, sodium bromate, periodic acid, sodium periodate, potassium permanganate, barium permanganate, chromic acid, etc. In addition, 0.8 to 2 equivalents can be used with respect to the compound of the present invention represented by the general formula (1-1).

  Although the addition of a catalyst is not necessarily required, when a catalyst is used, for example, vanadyl acetylacetonate, iron (III) acetylacetonate, magnesium bisulfite, ammonium molybdate, etc. are represented by the general formula (1-1). 0.001-0.5 equivalent can be used with respect to the compound of the present invention.

  In the case of using a solvent, the solvent to be used is not particularly limited as long as it does not inhibit the progress of the reaction. For example, aromatic hydrocarbons such as benzene, toluene and xylene, and aliphatic hydrocarbons such as hexane and heptane. , Cycloaliphatic hydrocarbons, chlorobenzene, dichlorobenzene and other aromatic halogenated hydrocarbons, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, 1,1,1-trichloroethane, trichloroethylene, tetrachloroethylene Aliphatic halogenated hydrocarbons such as alcohols such as methanol, ethanol and ethylene glycol, ketones such as acetone and methyl ethyl ketone, carboxylic acids such as acetic acid and propionic acid, esters such as ethyl acetate and ethyl propionate, N , N-dimethylformamide, N, N-dimethyl Acetamide, amides such as N- methyl-2-pyrrolidone, and acetonitrile and water and the like. These solvents may be used alone or as a mixture of two or more thereof.

  When using a base, for example, alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, alkaline earth metal hydroxides such as calcium hydroxide, alkali metal alkoxides such as sodium methoxide and sodium ethoxide, sodium carbonate , Alkali metal carbonates such as potassium carbonate, alkali metal bicarbonates such as sodium bicarbonate and potassium bicarbonate, alkali metal carboxylates such as sodium acetate, triethylamine, tributylamine, N, N-dimethylaniline, pyridine, 4 An organic base such as-(dimethylamino) pyridine, imidazole, 1,8-diazabicyclo [5,4,0] -7-undecene or the like is represented by 1 against the compound of the present invention represented by the general formula (1-1). ˜100 equivalents can be used.

  The reaction temperature can be set to an arbitrary temperature from −60 ° C. to the reflux temperature of the reaction mixture, and the reaction time varies depending on the concentration of the reaction substrate and the reaction temperature, but is usually arbitrarily within the range of 5 minutes to 100 hours. Can be set.

  In general, for example, 1 to 1.3 equivalents of bromine is used with respect to 1 equivalent of the compound of the present invention represented by the general formula (1-1), and 1 to 2 equivalents with respect to 1 equivalent of the compound of the present invention as a base. In the presence of sodium hydroxide, potassium hydrogen carbonate, etc., the reaction is carried out in a toluene-water solvent at a temperature ranging from 0 ° C. to room temperature for 5 minutes to 1 hour, or represented by the general formula (1-1) 0.8 to 1.5 equivalents of hydrogen peroxide, 3-chloroperbenzoic acid, etc. are used with respect to 1 equivalent of the compound of the present invention, and if necessary, 1 equivalent of the compound of the present invention represented by the general formula (1-1) 0.01 to 0.05 equivalents of vanadyl acetylacetonate, iron (III) acetylacetonate, and the like are added to the solvent, and in a solvent such as dichloromethane, chloroform and acetic acid at a temperature range of 0 to 60 ° C., The reaction is preferably carried out for 1 to 24 hours.

In addition, if necessary, the present compound represented by the general formula (1-1) or the present compound represented by the general formula (1-3) is used in a solvent inert to the reaction, if necessary. For example, the general formula (1-4) wherein r is 2 in the general formula (1) by oxidation with a general sulfide oxidizing agent in the presence of a suitable catalyst [wherein A ¹ , A ² , A ³ , G, X, Y, L, Q, R ³ , m and n have the same meaning as described above. This invention compound represented by this can be obtained.

  The oxidizing agent is not particularly limited as long as it is used for oxidation of ordinary sulfides. For example, organic peroxides such as peracetic acid and 3-chloroperbenzoic acid, hydrogen peroxide, periodic acid, periodate Sodium sulfate, potassium permanganate, barium permanganate, chromic acid and the like can be used in an amount of 2 to 4 equivalents with respect to the compound of the present invention represented by the general formula (1-1).

  Although the addition of a catalyst is not always necessary, when a catalyst is used, for example, a compound such as chromium (IV) oxide, ruthenium trichloride trihydrate, sodium tungstate, ammonium molybdate is represented by the general formula (1-1). 0.001 to 0.5 equivalent can be used with respect to the represented compound of the present invention.

  In the case of using a solvent, the solvent used is not particularly limited as long as it does not inhibit the progress of the reaction. For example, aromatic halogenated hydrocarbons such as chlorobenzene and dichlorobenzene, dichloromethane, chloroform, carbon tetrachloride, 1 Aliphatic halogenated hydrocarbons such as 1,2-dichloroethane, 1,1,1-trichloroethane, trichloroethylene, tetrachloroethylene, ketones such as acetone and methyl ethyl ketone, carboxylic acids such as acetic acid and propionic acid, ethyl acetate, ethyl propionate, etc. Esters, acetonitrile and water. These solvents may be used alone or as a mixture of two or more thereof.

  The reaction temperature can be set to an arbitrary temperature from −60 ° C. to the reflux temperature of the reaction mixture, and the reaction time varies depending on the concentration of the reaction substrate and the reaction temperature, but is usually arbitrarily within the range of 5 minutes to 100 hours. Can be set.

  In general, for example, 2 to 4 equivalents of hydrogen peroxide, 3-chloroperbenzoic acid, periodic acid, sodium periodate, etc. with respect to 1 equivalent of the compound of the present invention represented by the general formula (1-1) If necessary, 0.01 to 0.05 equivalents of chromium (IV) oxide, ruthenium trichloride trihydrate, tungstic acid with respect to 1 equivalent of the compound of the present invention represented by the general formula (1-1) It is preferable to add a catalyst such as sodium and perform the reaction in a solvent such as dichloromethane, acetic acid, acetonitrile, carbon tetrachloride-acetonitrile-water system at a temperature range of 0 to 90 ° C. for 1 to 48 hours.

  Manufacturing method D

General formula (6) [wherein A ¹ , A ² , A ³ , Y, L, Q and n represent the same meaning as described above. The compound represented by the general formula (7) [formula (7) is obtained by halogenating the compound represented by the above formula with a halogenating agent in the presence of a base if necessary using a solvent inert to the reaction. In the formula, A ¹ , A ² , A ³ , Y, L, Q and n represent the same meaning as described above, and J ³ represents a halogen atom such as a chlorine atom or a bromine atom. ] Can be obtained.

  Examples of the halogenating agent include N-halosuccinimides such as N-chlorosuccinimide and N-bromosuccinimide, alkali metal hypohalites such as sodium hypochlorite, and t-butyl hypochlorite. Hypohalous acid esters such as esters and simple halogens such as chlorine gas can be used in an amount of 1 to 10 equivalents with respect to the compound represented by the general formula (6).

  In the case of using a solvent, the solvent to be used is not particularly limited as long as it does not inhibit the progress of the reaction. For example, aromatic hydrocarbons such as benzene, toluene and xylene, and aliphatic hydrocarbons such as hexane and heptane. , Cycloaliphatic alicyclic hydrocarbons, chlorobenzene, dichlorobenzene and other aromatic halogenated hydrocarbons, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, 1,1,1-trichloroethane, trichloroethylene, tetrachloroethylene Aliphatic hydrocarbons such as diethyl ether, ethers such as 1,2-dimethoxyethane, tetrahydrofuran and 1,4-dioxane, esters such as ethyl acetate and ethyl propionate, N, N-dimethylformamide, Amides such as N, N-dimethylacetamide, N-methyl-2-pyrrolidone, Methanol, ethanol, alcohols such as ethylene glycol, acetate, carboxylic acids such as propionic acid, acetonitrile and water or the like. These solvents may be used alone or as a mixture of two or more thereof.

  The reaction temperature can be set to an arbitrary temperature from −60 ° C. to the reflux temperature of the reaction mixture, and the reaction time varies depending on the concentration of the reaction substrate and the reaction temperature, but is usually arbitrarily within a range of 5 minutes to 24 hours. Can be set.

The compound represented by the general formula (7) thus obtained and the general formula (8) [wherein G, X, R ³ and m represent the same meaning as described above. The compound represented by the general formula (1-4) wherein r is 2 in the general formula (1) is reacted in the presence of a base using a solvent inert to the reaction if necessary. In the formula, A ¹ , A ² , A ³ , G, X, Y, L, Q, R ³ , m and n have the same meaning as described above. This invention compound represented by this can be obtained.

  The amount of the reaction substrate may be 1 to 5 equivalents of the compound represented by the general formula (8) with respect to 1 equivalent of the compound represented by the general formula (7).

  Examples of the base to be used include alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, alkali metal carbonates such as sodium carbonate and potassium carbonate, alkali metal bicarbonates such as sodium bicarbonate and potassium bicarbonate, triethylamine, Organic bases such as tributylamine, N, N-dimethylaniline, pyridine, 4- (dimethylamino) pyridine, imidazole, and 1,8-diazabicyclo [5,4,0] -7-undecene are represented by the general formula (7) 1-5 equivalent can be used with respect to the compound represented by these.

  In the case of using a solvent, the solvent to be used is not particularly limited as long as it does not inhibit the progress of the reaction. For example, aromatic hydrocarbons such as benzene, toluene and xylene, and aliphatic hydrocarbons such as hexane and heptane. , Cycloaliphatic alicyclic hydrocarbons, chlorobenzene, dichlorobenzene and other aromatic halogenated hydrocarbons, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, 1,1,1-trichloroethane, trichloroethylene, tetrachloroethylene Aliphatic hydrocarbons such as diethyl ether, ethers such as 1,2-dimethoxyethane, tetrahydrofuran and 1,4-dioxane, esters such as ethyl acetate and ethyl propionate, N, N-dimethylformamide, Amides such as N, N-dimethylacetamide and N-methyl-2-pyrrolidone Acetonitrile. These solvents may be used alone or as a mixture of two or more thereof.

  The reaction temperature can be set to an arbitrary temperature from −60 ° C. to the reflux temperature of the reaction mixture, and the reaction time varies depending on the concentration of the reaction substrate and the reaction temperature, but is usually arbitrarily within the range of 5 minutes to 100 hours. Can be set.

  In general, for example, 1 to 2 equivalents of N-chlorosuccinimide, sodium hypochlorite aqueous solution, hypochlorous acid-t-butyl ester, chlorine with respect to 1 equivalent of the compound represented by the general formula (6) Use a halogenating agent such as gas, and use a solvent such as dichloromethane, chloroform, 1,2-dimethoxyethane, tetrahydrofuran, 1,4-dioxane, N, N-dimethylformamide, and the like. The compound represented by the general formula (7) can be obtained by performing the reaction within a range of 10 minutes to 2 hours. Next, without isolating the compound represented by the general formula (7), 1-2 equivalents of the compound represented by the general formula (8) and 1-2 equivalents of sodium carbonate, sodium bicarbonate, triethylamine, etc. It is preferable to add a base and carry out the reaction for 10 minutes to 24 hours in the range of 0 ° C. to the reflux temperature of these solvents.

  In production method A to production method D, the reaction mixture after completion of the reaction is directly concentrated, or dissolved in an organic solvent, concentrated after washing with water, or poured into ice water, followed by normal post-treatment such as extraction after organic solvent extraction. Of the present invention can be obtained. Moreover, when the necessity for purification arises, it can be separated and purified by any purification method such as recrystallization, column chromatograph, thin layer chromatograph, liquid chromatographic fractionation and the like.

  Some of the compounds represented by the general formula (3) used in the production method A and the production method B are known compounds described in the literature (WO 2005/085216 pamphlet), and other compounds are also available. It can be synthesized according to the method for synthesizing 3-halogen-substituted phenyl-5-substituted-5-substituted phenyl-4,5-dihydroisoxazole compounds described in this document.

  Some of the compounds represented by the general formula (4) used in the production method A are known compounds, and some of them are commercially available. Others can be synthesized according to the general synthesis method of thiols described in the literature.

  Some of the compounds represented by the general formula (5) used in the production method B are known compounds, and some of them are commercially available. Others can be easily synthesized according to general synthesis methods described in the literature.

  The compound represented by the general formula (6) used in production method D can be synthesized, for example, as follows.

  Reaction formula 1

That is, the general formula (9) [wherein A ¹ , A ² , A ³ , Y, L, Q and n represent the same meaning as described above. ] According to a known method described in the literature, for example, according to the method described in Journal of Medicinal Chemistry [J. Med. Chem.] 2001, 44, 2308, etc. By reacting with the salt, general formula (6) [wherein A ¹ , A ² , A ³ , Y, L, Q and n represent the same meaning as described above. ] Can be easily synthesized.

  The compound represented by the general formula (8) used in the production method D can be synthesized, for example, as follows.

  Reaction formula 2

That is, known general formula (10) [wherein G, X and m represent the same meaning as described above, J ⁴ represents a bromine atom, an iodine atom, a C ₁ -C ₄ haloalkylsulfonyloxy group (for example, trifluoromethanesulfonyl). Oxy group), -B (OH) ₂ group, 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl group, -Si (OEt) ₃ group, -ZnCl, -ZnBr group Or represents -ZnI group or the like. And a compound represented by the general formula (11) [wherein R ³ represents the same meaning as described above, and J ⁵ represents a halogen atom such as a bromine atom or an iodine atom or a —B (OH) ₂ group. And a compound represented by the above general cross-coupling reaction using a transition metal catalyst such as palladium described in the literature, for example, The Journal of Organic Chemistry [J. Org. Chem.] 1991, Vol. 7336, Tetrahedron Lett. 2001, 42, 4083, etc., by reacting according to the general formula (8) [wherein G, X, R ³ And m represent the same meaning as described above. The compound represented by this can be obtained.

  Some of the compounds represented by the general formula (11) used here are known compounds, and some of them are commercially available. Other methods are also known in the literature, such as Journal of the American Chemical Society [J. Am. Chem. Soc.] 1971, 93, 1925, Tetrahedron Letters [ Tetrahedron Lett.] 1990, 31, 1919 and 2001, 42, 4083, etc., can be easily synthesized.

In addition, the compound represented by the general formula (8) has the general formula (12) [wherein G, X, R ³ and m represent the same meaning as described above. The olefination reaction of a known carbonyl group described in the literature, for example, The Journal of Organic Chemistry [J. Org. Chem.] 1986, 51, 5252 and 1994, 59 Volume 2, page 2898, Synthesis 1991, page 29, Tetrahedron Lett. 1985, volume 26, page 5579, and the like.

  The compound represented by the general formula (9) can be synthesized, for example, as follows.

  Reaction formula 3

That is, the general formula (13) [wherein A ¹ , A ² , A ³ , Y, L, Q and n represent the same meaning as described above, J ⁶ represents a bromine atom, an iodine atom, a halosulfonyloxy group (for example, , fluoro sulfonyloxy group), represents a C ₁ -C ₄ haloalkylsulfonyl group (e.g., trifluoromethanesulfonyloxy group) or an arylsulfonyloxy group (e.g., benzenesulfonyloxy group). ], For example, Bulletin of the Chemical Society of Japan [Bull. Chem. Soc. Jpn.] 1994, 67, 2329, Journal of CO using a transition metal catalyst such as palladium in the presence of a hydride source such as formic acid according to the method described in The American Chemical Society [J. Am. Chem. Soc.] 1986, 108, 452 etc. By performing the insertion reaction, the general formula (9) [wherein A ¹ , A ² , A ³ , Y, L, Q and n represent the same meaning as described above. The compound represented by this can be obtained.

  The compound represented by the general formula (12) can be synthesized, for example, as follows.

  Reaction formula 4

That is, known general formula (14) [wherein X and m represent the same meaning as described above, and G represents a benzene ring. And a known general formula (15) [wherein R ³ represents the same meaning as described above, and J ⁷ represents a leaving group such as a halogen atom, a trifluoromethanesulfonyloxy group, a 2-pyridyloxy group, etc. Represents. Or a known general formula (16) wherein R ³ represents the same meaning as described above. The general aromatic ring acylation reaction described in the literature, for example, Chemistry Letters [Chem. Lett.] 1990, p. 783, The Journal of Organic Chemistry [J. Org Chem.] 1991, 56, 1963, etc., by reacting in accordance with the general formula (12) [wherein X, R ³ and m represent the same meaning as described above, G represents Represents a benzene ring. The compound represented by this can be obtained.

Alternatively, known general formula (17) [wherein G, X and m represent the same meaning as described above, and J ⁸ represents a bromine atom or an iodine atom. ] After lithiation of the compound represented by the literature, for example, known general formula (18) [wherein R ³ represents the same meaning as described above, J ⁹ represents a halogen atom, a hydroxyl group, metal salts _{(e.g., -OLi, -ONa), C 1} ~C 4 alkoxy group (e.g., methoxy group, ethoxy group), di (C ₁ -C ₄ alkyl) amino group (e.g., diethylamino group), C ₁ ~ C ₄ alkoxy (C ₁ -C ₄ alkyl) amino group (for example, O, N-dimethylhydroxyamino group) or cyclic amino group (for example, piperidin-1-yl group, morpholin-4-yl group, 4-methylpiperazine) -1-yl group). Or the known compound represented by the general formula (16) [J. Am. Chem. Soc.] 1955, 77, 3657 Tetrahedron Lett. 1980, 21, 2129 and 1991, 32, 2003, US Patent Application Publication (US 5,514,816), etc., or Grignard reactant Heterocycles 1987, Vol. 25, p. 221, Synthetic Communications [Synth. Communication, formed and then reacted with a compound represented by general formula (18) or a compound represented by general formula (16) In accordance with the method described in 1985, 15, 1291 and 1990, 20, 1469, German Patent Application Publication (DE 19727042), etc. Reaction, general formula (12) [wherein G, X, R ³ and m represent the same meaning as described above. The compound represented by this can also be obtained.

  The compound represented by the general formula (13) can be synthesized, for example, as follows.

  Reaction formula 5

That is, the known general formula (19) [wherein A ¹ , A ² , A ³ , Y, n and J ⁶ represent the same meaning as described above. And a compound represented by the general formula (5): wherein L, Q and J ² represent the same meaning as described above. And a compound represented by general formula (20) obtained by reacting in the same manner as in Production Method B, wherein A ¹ , A ² , A ³ , Y, L, Q, n and J ⁶ are Represents the same meaning as above. The compound represented by general formula (13) [wherein A ¹ , A ² , A ³ , Y, L, Q, n and J ⁶ are Represents the same meaning as above. The compound represented by this can be obtained.

  In each of these reactions, after the completion of the reaction, each of the production intermediates that are the raw material compounds of Production Method A to Production Method D can be obtained by carrying out ordinary post-treatment.

  In addition, each production intermediate produced by these methods can be used as it is in the subsequent step without isolation and purification.

  Specific examples of the compound included in the present invention include compounds shown in Tables 2 and 3. Specific examples of the compound that can be used as a novel production intermediate for producing the active compound included in the present invention include compounds shown in Table 4. However, the compounds in Tables 2 to 4 are for illustrative purposes, and the present invention is not limited thereto.

In the table, “Et” represents an ethyl group. Similarly, n-Pr and Pr-n are normal propyl groups, i-Pr and Pr-i are isopropyl groups, and c-Pr and Pr-c are Cyclopropyl group, n-Bu and Bu-n are normal butyl groups, s-Bu and Bu-s are secondary butyl groups, i-Bu and Bu-i are isobutyl groups, t-Bu and Bu-t Are tertiary butyl groups, c-Bu and Bu-c are cyclobutyl groups, n-Pen and Pen-n are normal pentyl groups, c-Pen and Pen-c are cyclopentyl groups, n-Hex and Hex- n represents a normal hexyl group, c-Hex and Hex-c represent a cyclohexyl group, Ph represents a phenyl group,
The aromatic heterocycles represented by D1-1a to D37-1a in the table each represent the following structure,

For example, [CH ₂ (D8-3b) Cl] represents a 3-chloro-1-methylpyrazol-5-ylmethyl group, and [CH ₂ (D32-1d) Cl] represents 5-chloropyridine-2. -Represents an ylmethyl group.

  In addition, the aliphatic heterocycles represented by E3-1a to E11-1a in the table each represent the following structure,

For example, [CH ₂ (E5-2a) C (O) OCH ₃ ] represents a 1-methoxycarbonyl-3-pyrrolidinylmethyl group, and [CH ₂ (E6-1a)] represents 1,3 -Represents a dioxolan-2-ylmethyl group.

  Furthermore, the partially saturated heterocyclic rings represented by M1-1a to M21-1a in the table each represent the following structure,

For example, the notation [CH ₂ (M3-1b) CF ₃ ] represents a 5-trifluoromethyl-4,5-dihydroisoxazol-3-ylmethyl group, and the notation [CH ₂ (M11-1a) H] Represents a 4,5-didihydroimidazol-2-ylmethyl group.

  Furthermore, T-3 to T-15 in the table each represent the following structure.

Table 2 In the table, the number representing the substitution position of the substituent (X) _m corresponds to the position of the number described in the following structural formula, respectively, and the-sign represents no substitution. .

―――――――――――――――――――――――――――――――――――――――
(X)_m                       R^Three              S (O)_r-L-Q
―――――――――――――――――――――――――――――――――――――――
3-F CF_Three             SCH_Three
3-F CF_Three             SCH₂C (O) NHCH₂CF_Three
4-F CF_Three             SCH_Three
3-Cl CF_Three             SCH_Three
3-Cl CF_Three             S (O) CH_Three
3-Cl CF_Three             SO₂CH_Three
3-Cl CF_Three             SCH₂C (O) NHCH₂CF_Three
4-Cl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br CF_Three             SCH_Three
3-Br CF_Three             S (O) CH_Three
3-Br CF_Three             SO₂CH_Three
3-Br CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Br CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Br CF₂Cl SCH_Three
3-Br CF₂Cl SCH₂C (O) NHCH₂CF_Three
4-Br CF_Three             SCH_Three
3-I CHF₂            SCH₂C (O) NHCH₂CF_Three
3-I CF_Three             SCH_Three
3-I CF_Three             S (O) CH_Three
3-I CF_Three             SO₂CH_Three
3-I CF_Three             SCH₂F
3-I CF_Three             S (O) CH₂F
3-I CF_Three             SO₂CH₂F
3-I CF_Three             SCHF₂
3-I CF_Three             S (O) CHF₂
3-I CF_Three             SO₂CHF₂
3-I CF_Three             SCF_Three
3-I CF_Three             S (O) CF_Three
3-I CF_Three             SO₂CF_Three
3-I CF_Three             SCH₂C (O) NHCH₂CF_Three
3-I CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-I CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-I CF₂Cl SCH_Three
3-I CF₂Cl S (O) CH_Three
3-I CF₂Cl SO₂CH_Three
3-I CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-I CF₂Br SCH_Three
3-I CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
4-I CF_Three             SCH_Three
3-CH_Three                      CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Et CF_Three             SCH_Three
3-Pr-i CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Bu-t CF_Three             SCH_Three
3-CF_Three                      CHF₂            SCH₂C (O) NHCH₂CF_Three
3-CF_Three                      CF_Three             SCH_Three
3-CF_Three                      CF_Three             S (O) CH_Three
3-CF_Three                      CF_Three             SO₂CH_Three
3-CF_Three                      CF_Three             SCH₂F
3-CF_Three                      CF_Three             S (O) CH₂F
3-CF_Three                      CF_Three             SO₂CH₂F
3-CF_Three                      CF_Three             SCHF₂
3-CF_Three                      CF_Three             S (O) CHF₂
3-CF_Three                      CF_Three             SO₂CHF₂
3-CF_Three                      CF_Three             SCF_Three
3-CF_Three                      CF_Three             S (O) CF_Three
3-CF_Three                      CF_Three             SO₂CF_Three
3-CF_Three                      CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three                      CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-CF_Three                      CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-CF_Three                      CF₂Cl SCH_Three
3-CF_Three                      CF₂Cl S (O) CH_Three
3-CF_Three                      CF₂Cl SO₂CH_Three
3-CF_Three                      CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-CF_Three                      CF₂Br SCH_Three
3-CF_Three                      CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CHF₂            SCH_Three
3-CF₂CF_Three                   CF_Three             SCH_Three
3-CF₂CF_Three                   CF_Three             S (O) CH_Three
3-CF₂CF_Three                   CF_Three             SO₂CH_Three
3-CF₂CF_Three                   CF_Three             SCH₂F
3-CF₂CF_Three                   CF_Three             S (O) CH₂F
3-CF₂CF_Three                   CF_Three             SO₂CH₂F
3-CF₂CF_Three                   CF_Three             SCHF₂
3-CF₂CF_Three                   CF_Three             S (O) CHF₂
3-CF₂CF_Three                   CF_Three             SO₂CHF₂
3-CF₂CF_Three                   CF_Three             SCF_Three
3-CF₂CF_Three                   CF_Three             S (O) CF_Three
3-CF₂CF_Three                   CF_Three             SO₂CF_Three
3-CF₂CF_Three                   CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF₂Cl SCH_Three
3-CF₂CF_Three                   CF₂Cl S (O) CH_Three
3-CF₂CF_Three                   CF₂Cl SO₂CH_Three
3-CF₂CF_Three                   CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF₂Br SCH₂C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF₂CHF₂         SCH_Three
3-CF₂CF₂CF_Three                CF_Three             SCH_Three
3-CF₂CF₂CF_Three                CF_Three             S (O) CH_Three
3-CF₂CF₂CF_Three                CF_Three             SO₂CH_Three
3-CF₂CF₂CF_Three                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF₂CF₂CF_Three                CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-CF₂CF₂CF_Three                CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-CF₂CF₂CF_Three                CF₂Cl SCH_Three
3-CF₂CF₂CF_Three                CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-CF (CF_Three)₂                 CF_Three             SCH_Three
3-CF (CF_Three)₂                 CF_Three             S (O) CH_Three
3-CF (CF_Three)₂                 CF_Three             SO₂CH_Three
3-CF (CF_Three)₂                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF (CF_Three)₂                 CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-CF (CF_Three)₂                 CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-CF (CF_Three)₂                 CF₂Cl SCH_Three
3-CF (CF_Three)₂                 CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-CF₂CF₂CF₂CF_Three             CF_Three             SCH_Three
3-CF₂CF₂CF₂CF_Three             CF_Three             S (O) CH_Three
3-CF₂CF₂CF₂CF_Three             CF_Three             SO₂CH_Three
3-CF₂CF₂CF₂CF_Three             CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH₂OCH₂CF_Three               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-C (CF_Three)₂OH CF_Three             SCH_Three
3-C (CF_Three)₂OH CF_Three             S (O) CH_Three
3-C (CF_Three)₂OH CF_Three             SO₂CH_Three
3-C (CF_Three)₂OH CF_Three             SCH₂C (O) NHCH₂CF_Three
3-C (CF_Three)₂OCH_Three              CF_Three             SCH_Three
3-C (CF_Three)₂OCH_Three              CF_Three             S (O) CH_Three
3-C (CF_Three)₂OCH_Three              CF_Three             SO₂CH_Three
3-C (CF_Three)₂OCH_Three              CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH₂SCH_Three                  CF_Three             SCH_Three
3-CH₂SEt CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH₂SPr-i CF_Three             SCH_Three
3-CH₂SPr-c CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH₂SCF_Three                  CF_Three             SCH_Three
3-CH₂S (O) CF_Three               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH₂SO₂CF_Three                CF_Three             SCH_Three
3-CH₂SCH₂CF_Three               CF_Three             SCH₂C (O) NHCH₂CF_Three
3- (T-3) CF_Three             SCH_Three
3- (T-4) CF_Three             SCH₂C (O) NHCH₂CF_Three
3- (T-5) CF_Three             SCH_Three
3-OCHF₂                    CF_Three             SCH₂C (O) NHCH₂CF_Three
4-OCHF₂                    CF_Three             SCH_Three
3-OCF_Three                     CF_Three             SCH_Three
3-OCF_Three                     CF_Three             S (O) CH_Three
3-OCF_Three                     CF_Three             SO₂CH_Three
3-OCF_Three                     CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCF_Three                     CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-OCF₂Br CF_Three             SCH_Three
3-OCF₂Br CF_Three             S (O) CH_Three
3-OCF₂Br CF_Three             SO₂CH_Three
3-OCF₂Br CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCF₂Br CF₂Cl SCH_Three
3-OCH₂CH₂Cl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCH₂CF_Three                  CF_Three             SCH_Three
3-OCF₂CHF₂                 CF_Three             SCH_Three
3-OCF₂CHF₂                 CF_Three             S (O) CH_Three
3-OCF₂CHF₂                 CF_Three             SO₂CH_Three
3-OCF₂CHF₂                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCF₂CHFCl CF_Three             SCH_Three
3-OCF₂CHFCl CF_Three             S (O) CH_Three
3-OCF₂CHFCl CF_Three             SO₂CH_Three
3-OCF₂CHFCl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCF₂CHFBr CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCF₂CF₂Br CF_Three             SCH_Three
3-OCF₂CFCl₂                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCF₂CCl_Three                 CF_Three             SCH_Three
3-OCH₂CF₂CHF₂              CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCF₂CHFCF_Three               CF_Three             SCH_Three
3-OCF₂CHFCF_Three               CF_Three             S (O) CH_Three
3-OCF₂CHFCF_Three               CF_Three             SO₂CH_Three
3-OCF₂CHFCF_Three               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCH (CF_Three)₂                CF_Three             SCH_Three
3-OCF₂CFBrCF_Three              CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCF₂CHFOCF_Three              CF_Three             SCH_Three
3-OCF₂CHFOCF_Three              CF_Three             S (O) CH_Three
3-OCF₂CHFOCF_Three              CF_Three             SO₂CH_Three
3-OCF₂CHFOCF_Three              CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCF₂CHFOCF₂CF₂CF_Three        CF_Three             SCH_Three
3-OCH₂CH = CF₂               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCH₂CF = CF₂               CF_Three             SCH_Three
3-OCH₂CH = CCl₂              CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCH₂CCl = CCl₂             CF_Three             SCH_Three
3-OSO₂CHCl₂                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OSO₂CF_Three                  CF_Three             SCH_Three
3-OSO₂CH₂CF_Three               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OPh CF_Three             SCH_Three
3-SCH_Three                     CF_Three             SCH₂C (O) NHCH₂CF_Three
3-S (O) CH_Three                  CF_Three             SCH_Three
3-SO₂CH_Three                   CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SCH₂F CF_Three             SCH_Three
3-S (O) CH₂F CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SO₂CH₂F CF_Three             SCH_Three
3-SCHF₂                    CF_Three             SCH₂C (O) NHCH₂CF_Three
3-S (O) CHF₂                 CF_Three             SCH_Three
3-SO₂CHF₂                  CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SCF_Three                     CF_Three             SCH_Three
3-SCF_Three                     CF_Three             S (O) CH_Three
3-SCF_Three                     CF_Three             SO₂CH_Three
3-SCF_Three                     CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SCF_Three                     CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-SCF_Three                     CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-SCF_Three                     CF₂Cl SCH_Three
3-SCF_Three                     CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-S (O) CF_Three                  CF_Three             SCH_Three
3-SO₂CF_Three                   CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SCF₂Cl CF_Three             SCH_Three
3-SCF₂Cl CF_Three             S (O) CH_Three
3-SCF₂Cl CF_Three             SO₂CH_Three
3-SCF₂Cl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SCF₂Cl CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-SCF₂Cl CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-SCF₂Cl CF₂Cl SCH_Three
3-SCF₂Cl CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-S (O) CF₂Cl CF_Three             SCH_Three
3-SO₂CF₂Cl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SCF₂Br CF_Three             SCH_Three
3-SCF₂Br CF_Three             S (O) CH_Three
3-SCF₂Br CF_Three             SO₂CH_Three
3-SCF₂Br CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SCF₂Br CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-SCF₂Br CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-SCF₂Br CF₂Cl SCH_Three
3-SCF₂Br CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-S (O) CF₂Br CF_Three             SCH_Three
3-SO₂CF₂Br CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SCH₂CF_Three                  CF_Three             SCH_Three
3-SCF₂CHF₂                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SCF₂CHFCl CF_Three             SCH_Three
3-SCF₂CF_Three                  CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SCF₂CF₂Br CF_Three             SCH_Three
3-SCF₂CHFCF_Three               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SCF₂CF₂CF_Three               CF_Three             SCH_Three
3-SO₂NHCH_Three                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SO₂N (CH_Three)₂               CF_Three             SCH_Three
3-S (Ph-4-Cl) CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SF_Five                      CHF₂            SCH_Three
3-SF_Five                      CF_Three             SCH_Three
3-SF_Five                      CF_Three             S (O) CH_Three
3-SF_Five                      CF_Three             SO₂CH_Three
3-SF_Five                      CF_Three             SCH₂F
3-SF_Five                      CF_Three             S (O) CH₂F
3-SF_Five                      CF_Three             SO₂CH₂F
3-SF_Five                      CF_Three             SCHF₂
3-SF_Five                      CF_Three             S (O) CHF₂
3-SF_Five                      CF_Three             SO₂CHF₂
3-SF_Five                      CF_Three             SCF_Three
3-SF_Five                      CF_Three             S (O) CF_Three
3-SF_Five                      CF_Three             SO₂CF_Three
3-SF_Five                      CF_Three             SCH₂C (O) NHCH₂CF_Three
3-SF_Five                      CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-SF_Five                      CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-SF_Five                      CF₂Cl SCH_Three
3-SF_Five                      CF₂Cl S (O) CH_Three
3-SF_Five                      CF₂Cl SO₂CH_Three
3-SF_Five                      CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-SF_Five                      CF₂Br SCH₂C (O) NHCH₂CF_Three
3-SF_Five                      CF₂CHF₂         SCH_Three
3-NO₂                      CF_Three             SCH₂C (O) NHCH₂CF_Three
3-NHSO₂CF_Three                 CF_Three             SCH_Three
3-Si (CH_Three)_Three                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CN CF_Three             SCH_Three
3-C (O) NH₂                  CF_Three             SCH₂C (O) NHCH₂CF_Three
3-C (S) NH₂                  CF_Three             SCH_Three
2,3-F₂                     CF_Three             SCH₂C (O) NHCH₂CF_Three
2,4-F₂                     CF_Three             SCH_Three
2,5-F₂                     CF_Three             SCH₂C (O) NHCH₂CF_Three
3,4-F₂                     CF_Three             SCH_Three
3,4-F₂                     CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-F₂                     CF_Three             SCH_Three
3,5-F₂                     CF_Three             SCH₂C (O) NHCH₂CF_Three
2-F-3-Cl CF_Three             SCH_Three
3-Cl-4-F CHF₂            SCH₂C (O) NHCH₂CF_Three
3-Cl-4-F CF_Three             SCH_Three
3-Cl-4-F CF_Three             S (O) CH_Three
3-Cl-4-F CF_Three             SO₂CH_Three
3-Cl-4-F CF_Three             SCH₂F
3-Cl-4-F CF_Three             S (O) CH₂F
3-Cl-4-F CF_Three             SO₂CH₂F
3-Cl-4-F CF_Three             SCHF₂
3-Cl-4-F CF_Three             S (O) CHF₂
3-Cl-4-F CF_Three             SO₂CHF₂
3-Cl-4-F CF_Three             SCF_Three
3-Cl-4-F CF_Three             S (O) CF_Three
3-Cl-4-F CF_Three             SO₂CF_Three
3-Cl-4-F CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-4-F CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Cl-4-F CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Cl-4-F CF₂Cl SCH_Three
3-Cl-4-F CF₂Cl S (O) CH_Three
3-Cl-4-F CF₂Cl SO₂CH_Three
3-Cl-4-F CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-Cl-4-F CF₂Br SCH_Three
3-Cl-4-F CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
2-F-4-Cl CF_Three             SCH_Three
3-F-4-Cl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-F-5-Cl CHF₂            SCH_Three
3-F-5-Cl CF_Three             SCH_Three
3-F-5-Cl CF_Three             S (O) CH_Three
3-F-5-Cl CF_Three             SO₂CH_Three
3-F-5-Cl CF_Three             SCH₂F
3-F-5-Cl CF_Three             S (O) CH₂F
3-F-5-Cl CF_Three             SO₂CH₂F
3-F-5-Cl CF_Three             SCHF₂
3-F-5-Cl CF_Three             S (O) CHF₂
3-F-5-Cl CF_Three             SO₂CHF₂
3-F-5-Cl CF_Three             SCF_Three
3-F-5-Cl CF_Three             S (O) CF_Three
3-F-5-Cl CF_Three             SO₂CF_Three
3-F-5-Cl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-F-5-Cl CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-F-5-Cl CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-F-5-Cl CF₂Cl SCH_Three
3-F-5-Cl CF₂Cl S (O) CH_Three
3-F-5-Cl CF₂Cl SO₂CH_Three
3-F-5-Cl CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-F-5-Cl CF₂Br SCH₂C (O) NHCH₂CF_Three
3-F-5-Cl CF₂CHF₂         SCH_Three
2,3-Cl₂                    CF_Three             SCH₂C (O) NHCH₂CF_Three
2,5-Cl₂                    CF_Three             SCH_Three
3,4-Cl₂                    CHF₂            SCH₂C (O) NHCH₂CF_Three
3,4-Cl₂                    CF_Three             SCH_Three
3,4-Cl₂                    CF_Three             S (O) CH_Three
3,4-Cl₂                    CF_Three             SO₂CH_Three
3,4-Cl₂                    CF_Three             SCH₂F
3,4-Cl₂                    CF_Three             S (O) CH₂F
3,4-Cl₂                    CF_Three             SO₂CH₂F
3,4-Cl₂                    CF_Three             SCHF₂
3,4-Cl₂                    CF_Three             S (O) CHF₂
3,4-Cl₂                    CF_Three             SO₂CHF₂
3,4-Cl₂                    CF_Three             SCF_Three
3,4-Cl₂                    CF_Three             S (O) CF_Three
3,4-Cl₂                    CF_Three             SO₂CF_Three
3,4-Cl₂                    CF_Three             SCH₂C (O) NHCH₂CF_Three
3,4-Cl₂                    CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3,4-Cl₂                    CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3,4-Cl₂                    CF₂Cl SCH_Three
3,4-Cl₂                    CF₂Cl S (O) CH_Three
3,4-Cl₂                    CF₂Cl SO₂CH_Three
3,4-Cl₂                    CF₂Cl SCH₂C (O) NHCH₂CF_Three
3,4-Cl₂                    CF₂Br SCH_Three
3,4-Cl₂                    CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CH_Three             SCH_Three
3,5-Cl₂                    Et SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    n-Pr SCH_Three
3,5-Cl₂                    i-Pr SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    c-Pr SCH_Three
3,5-Cl₂                    CH₂F SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CH₂Cl SCH_Three
3,5-Cl₂                    CH₂Br SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CH₂I SCH_Three
3,5-Cl₂                    CHF₂            SCH_Three
3,5-Cl₂                    CHF₂            S (O) CH_Three
3,5-Cl₂                    CHF₂            SO₂CH_Three
3,5-Cl₂                    CHF₂            SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CHFCl SCH_Three
3,5-Cl₂                    CHFCl SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CHCl₂           SCH_Three
3,5-Cl₂                    CHCl₂           SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CHFBr SCH_Three
3,5-Cl₂                    CHFBr SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH_Three
3,5-Cl₂                    CF_Three             S (O) CH_Three
3,5-Cl₂                    CF_Three             SO₂CH_Three
3,5-Cl₂                    CF_Three             SEt
3,5-Cl₂                    CF_Three             S (O) Et
3,5-Cl₂                    CF_Three             SO₂Et
3,5-Cl₂                    CF_Three             SPr-n
3,5-Cl₂                    CF_Three             S (O) Pr-n
3,5-Cl₂                    CF_Three             SO₂Pr-n
3,5-Cl₂                    CF_Three             SPr-i
3,5-Cl₂                    CF_Three             S (O) Pr-i
3,5-Cl₂                    CF_Three             SO₂Pr-i
3,5-Cl₂                    CF_Three             SPr-c
3,5-Cl₂                    CF_Three             S (O) Pr-c
3,5-Cl₂                    CF_Three             SO₂Pr-c
3,5-Cl₂                    CF_Three             SBu-n
3,5-Cl₂                    CF_Three             S (O) Bu-n
3,5-Cl₂                    CF_Three             SO₂Bu-n
3,5-Cl₂                    CF_Three             SBu-i
3,5-Cl₂                    CF_Three             S (O) Bu-i
3,5-Cl₂                    CF_Three             SO₂Bu-i
3,5-Cl₂                    CF_Three             SCH₂Pr-c
3,5-Cl₂                    CF_Three             S (O) CH₂Pr-c
3,5-Cl₂                    CF_Three             SO₂CH₂Pr-c
3,5-Cl₂                    CF_Three             SBu-s
3,5-Cl₂                    CF_Three             S (O) Bu-s
3,5-Cl₂                    CF_Three             SO₂Bu-s
3,5-Cl₂                    CF_Three             SBu-t
3,5-Cl₂                    CF_Three             S (O) Bu-t
3,5-Cl₂                    CF_Three             SO₂Bu-t
3,5-Cl₂                    CF_Three             SPen-n
3,5-Cl₂                    CF_Three             S (O) Pen-n
3,5-Cl₂                    CF_Three             SO₂Pen-n
3,5-Cl₂                    CF_Three             SHex-n
3,5-Cl₂                    CF_Three             S (O) Hex-n
3,5-Cl₂                    CF_Three             SO₂Hex-n
3,5-Cl₂                    CF_Three             SCH₂F
3,5-Cl₂                    CF_Three             S (O) CH₂F
3,5-Cl₂                    CF_Three             SO₂CH₂F
3,5-Cl₂                    CF_Three             SCH₂Cl
3,5-Cl₂                    CF_Three             S (O) CH₂Cl
3,5-Cl₂                    CF_Three             SO₂CH₂Cl
3,5-Cl₂                    CF_Three             SCHF₂
3,5-Cl₂                    CF_Three             S (O) CHF₂
3,5-Cl₂                    CF_Three             SO₂CHF₂
3,5-Cl₂                    CF_Three             SCHFCl
3,5-Cl₂                    CF_Three             S (O) CHFCl
3,5-Cl₂                    CF_Three             SO₂CHFCl
3,5-Cl₂                    CF_Three             SCF_Three
3,5-Cl₂                    CF_Three             S (O) CF_Three
3,5-Cl₂                    CF_Three             SO₂CF_Three
3,5-Cl₂                    CF_Three             SCF₂Cl
3,5-Cl₂                    CF_Three             S (O) CF₂Cl
3,5-Cl₂                    CF_Three             SO₂CF₂Cl
3,5-Cl₂                    CF_Three             SCFCl₂
3,5-Cl₂                    CF_Three             S (O) CFCl₂
3,5-Cl₂                    CF_Three             SO₂CFCl₂
3,5-Cl₂                    CF_Three             SCF₂Br
3,5-Cl₂                    CF_Three             S (O) CF₂Br
3,5-Cl₂                    CF_Three             SO₂CF₂Br
3,5-Cl₂                    CF_Three             SCF₂I
3,5-Cl₂                    CF_Three             S (O) CF₂I
3,5-Cl₂                    CF_Three             SO₂CF₂I
3,5-Cl₂                    CF_Three             SCH₂CH₂F
3,5-Cl₂                    CF_Three             S (O) CH₂CH₂F
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂F
3,5-Cl₂                    CF_Three             SCH₂CH₂Cl
3,5-Cl₂                    CF_Three             S (O) CH₂CH₂Cl
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂Cl
3,5-Cl₂                    CF_Three             SCHClCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂Br
3,5-Cl₂                    CF_Three             S (O) CH₂CH₂Br
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂Br
3,5-Cl₂                    CF_Three             SCH₂CHF₂
3,5-Cl₂                    CF_Three             S (O) CH₂CHF₂
3,5-Cl₂                    CF_Three             SO₂CH₂CHF₂
3,5-Cl₂                    CF_Three             SCH₂CHFCl
3,5-Cl₂                    CF_Three             S (O) CH₂CHFCl
3,5-Cl₂                    CF_Three             SO₂CH₂CHFCl
3,5-Cl₂                    CF_Three             SCH₂CHCl₂
3,5-Cl₂                    CF_Three             S (O) CH₂CHCl₂
3,5-Cl₂                    CF_Three             SO₂CH₂CHCl₂
3,5-Cl₂                    CF_Three             SCH₂CHFBr
3,5-Cl₂                    CF_Three             S (O) CH₂CHFBr
3,5-Cl₂                    CF_Three             SO₂CH₂CHFBr
3,5-Cl₂                    CF_Three             SCH₂CF_Three
3,5-Cl₂                    CF_Three             S (O) CH₂CF_Three
3,5-Cl₂                    CF_Three             SO₂CH₂CF_Three
3,5-Cl₂                    CF_Three             SCHFCHF₂
3,5-Cl₂                    CF_Three             S (O) CHFCHF₂
3,5-Cl₂                    CF_Three             SO₂CHFCHF₂
3,5-Cl₂                    CF_Three             SCH₂CF₂Cl
3,5-Cl₂                    CF_Three             S (O) CH₂CF₂Cl
3,5-Cl₂                    CF_Three             SO₂CH₂CF₂Cl
3,5-Cl₂                    CF_Three             SCH₂CFCl₂
3,5-Cl₂                    CF_Three             S (O) CH₂CFCl₂
3,5-Cl₂                    CF_Three             SO₂CH₂CFCl₂
3,5-Cl₂                    CF_Three             SCH₂CCl_Three
3,5-Cl₂                    CF_Three             S (O) CH₂CCl_Three
3,5-Cl₂                    CF_Three             SO₂CH₂CCl_Three
3,5-Cl₂                    CF_Three             SCH₂CF₂Br
3,5-Cl₂                    CF_Three             S (O) CH₂CF₂Br
3,5-Cl₂                    CF_Three             SO₂CH₂CF₂Br
3,5-Cl₂                    CF_Three             SCH₂CFClBr
3,5-Cl₂                    CF_Three             S (O) CH₂CFClBr
3,5-Cl₂                    CF_Three             SO₂CH₂CFClBr
3,5-Cl₂                    CF_Three             SCH₂CCl₂Br
3,5-Cl₂                    CF_Three             S (O) CH₂CCl₂Br
3,5-Cl₂                    CF_Three             SO₂CH₂CCl₂Br
3,5-Cl₂                    CF_Three             SCHFCF_Three
3,5-Cl₂                    CF_Three             S (O) CHFCF_Three
3,5-Cl₂                    CF_Three             SO₂CHFCF_Three
3,5-Cl₂                    CF_Three             SCF₂CHF₂
3,5-Cl₂                    CF_Three             S (O) CF₂CHF₂
3,5-Cl₂                    CF_Three             SO₂CF₂CHF₂
3,5-Cl₂                    CF_Three             SCF₂CHFCl
3,5-Cl₂                    CF_Three             S (O) CF₂CHFCl
3,5-Cl₂                    CF_Three             SO₂CF₂CHFCl
3,5-Cl₂                    CF_Three             SCF₂CF_Three
3,5-Cl₂                    CF_Three             S (O) CF₂CF_Three
3,5-Cl₂                    CF_Three             SO₂CF₂CF_Three
3,5-Cl₂                    CF_Three             SCF₂CF₂Cl
3,5-Cl₂                    CF_Three             S (O) CF₂CF₂Cl
3,5-Cl₂                    CF_Three             SO₂CF₂CF₂Cl
3,5-Cl₂                    CF_Three             SCF₂CF₂Br
3,5-Cl₂                    CF_Three             S (O) CF₂CF₂Br
3,5-Cl₂                    CF_Three             SO₂CF₂CF₂Br
3,5-Cl₂                    CF_Three             SCFClCF₂Cl
3,5-Cl₂                    CF_Three             S (O) CFClCF₂Cl
3,5-Cl₂                    CF_Three             SO₂CFClCF₂Cl
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂F
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂F (R)
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂F (S)
3,5-Cl₂                    CF_Three             SO₂CH (CH_Three) CH₂F
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂Cl
3,5-Cl₂                    CF_Three             SO₂CH (CH_Three) CH₂Br
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂Br (R)
3,5-Cl₂                    CF_Three             SO₂CH (CH_Three) CH₂Br (S)
3,5-Cl₂                    CF_Three             SCH₂CHFCH_Three
3,5-Cl₂                    CF_Three             SO₂CH₂CHClCH_Three
3,5-Cl₂                    CF_Three             SCH₂CHBrCH_Three
3,5-Cl₂                    CF_Three             SO₂CH₂CFClCH_Three
3,5-Cl₂                    CF_Three             SCH₂CHClCH₂Cl
3,5-Cl₂                    CF_Three             SO₂CH₂CHBrCH₂F
3,5-Cl₂                    CF_Three             SCH₂CHClCH₂Br
3,5-Cl₂                    CF_Three             SO₂CH₂CHBrCH₂Cl
3,5-Cl₂                    CF_Three             SCH₂CClBrCH_Three
3,5-Cl₂                    CF_Three             SO₂CH₂CHBrCH₂Br
3,5-Cl₂                    CF_Three             SCH₂CH₂CF_Three
3,5-Cl₂                    CF_Three             SO₂CHF₂CF₂CH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂CF₂Br
3,5-Cl₂                    CF_Three             SO₂CH₂CClBrCH₂Cl
3,5-Cl₂                    CF_Three             SCH₂CF₂CHF₂
3,5-Cl₂                    CF_Three             SO₂CH₂CHClCF_Three
3,5-Cl₂                    CF_Three             SCH₂CF₂CF_Three
3,5-Cl₂                    CF_Three             SO₂CHFCF₂CHF₂
3,5-Cl₂                    CF_Three             SCH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH₂OEt
3,5-Cl₂                    CF_Three             SCH₂OPr-n
3,5-Cl₂                    CF_Three             SCH₂OPr-i
3,5-Cl₂                    CF_Three             SCH₂OBu-i
3,5-Cl₂                    CF_Three             SCH₂OBu-t
3,5-Cl₂                    CF_Three             SCH₂OCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂OCH (CH_Three) OEt
3,5-Cl₂                    CF_Three             SCH₂OCH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH₂OCH₂CH₂OEt
3,5-Cl₂                    CF_Three             SCH₂OCH₂CH₂OCH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH₂OCH₂CH₂OC (O) CH_Three
3,5-Cl₂                    CF_Three             SCH₂OCH₂CH₂Si (CH_Three)_Three
3,5-Cl₂                    CF_Three             SCH₂OCH₂CH = CH₂
3,5-Cl₂                    CF_Three             SCH₂OCH (CH_Three) CH = CH₂
3,5-Cl₂                    CF_Three             SCH₂OCH₂C≡CH
3,5-Cl₂                    CF_Three             SCH (CH_Three) OCH_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) OEt
3,5-Cl₂                    CF_Three             SO₂CH (CH_Three) OCH (CH_Three) OEt
3,5-Cl₂                    CF_Three             SCH (CH_Three) OC (O) CH_Three
3,5-Cl₂                    CF_Three             S (O) CH (CH_Three) OC (O) Bu-t
3,5-Cl₂                    CF_Three             SCH (CH_Three) OSi (CH_Three)_Three
3,5-Cl₂                    CF_Three             SC (CH_Three)₂OCH_Three
3,5-Cl₂                    CF_Three             SC (CH_Three)₂OEt
3,5-Cl₂                    CF_Three             SC (CH_Three)₂OSi (CH_Three)_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             S (O) CH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OEt
3,5-Cl₂                    CF_Three             SCH₂CH₂OPr-n
3,5-Cl₂                    CF_Three             SCH₂CH₂OPr-i
3,5-Cl₂                    CF_Three             SCH₂CH₂OCH₂CH₂Cl
3,5-Cl₂                    CF_Three             SCH₂CH₂OCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OCH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OCH₂CH₂OCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OCH₂CH₂OCH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OCH₂CH₂SCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OCH₂CH₂SCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OCH₂Ph
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) CH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHEt
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHPr-i
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHBu-t
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) (T-7)
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) (T-10)
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHCH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) (T-11)
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHCH₂CH₂SCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHCH₂CH₂CH₂SO₂CH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) (T-12)
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHCH₂Ph
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHCH₂(D32-1a)
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHCH₂(D32-2a)
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHCH₂(D32-3a)
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (O) NHPh
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (S) NHCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (S) NHEt
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (S) N (CH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂CH₂OC (S) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂OP (O) (OEt)₂
3,5-Cl₂                    CF_Three             SCH₂CH₂OP (S) (OCH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂CH₂OP (S) (OEt)₂
3,5-Cl₂                    CF_Three             SCH₂CH₂OPh
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂O (Ph-2-F)
3,5-Cl₂                    CF_Three             SCH₂CH₂O (Ph-3-F)
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂O (Ph-4-F)
3,5-Cl₂                    CF_Three             SCH₂CH (OCH_Three)₂
3,5-Cl₂                    CF_Three             S (O) CH₂CH (OCH_Three)₂
3,5-Cl₂                    CF_Three             SO₂CH₂CH (OCH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂CH (OEt)₂
3,5-Cl₂                    CF_Three             SCH₂C (CH_Three)₂OSi (CH_Three)_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂OCH_Three(R)
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂OCH_Three(S)
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂OC (O) CH_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂OC (O) NHCH_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂OC (O) NHEt
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂OC (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂OC (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂OC (O) NHPh
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂OPh
3,5-Cl₂                    CF_Three             SC (CH_Three)₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH₂(E3-1a)
3,5-Cl₂                    CF_Three             SCH₂(E3-2a)
3,5-Cl₂                    CF_Three             SCH₂(E6-1a)
3,5-Cl₂                    CF_Three             SCH₂(E6-2a)
3,5-Cl₂                    CF_Three             SCHFCF₂(E3-1a)
3,5-Cl₂                    CF_Three             S (E3-1a)
3,5-Cl₂                    CF_Three             S (E3-2a)
3,5-Cl₂                    CF_Three             SCH₂SCH_Three
3,5-Cl₂                    CF_Three             SCH₂SO₂CH_Three
3,5-Cl₂                    CF_Three             SCH₂SEt
3,5-Cl₂                    CF_Three             S (O) CH₂SEt
3,5-Cl₂                    CF_Three             SCH₂SPr-n
3,5-Cl₂                    CF_Three             SCH₂SO₂CF_Three
3,5-Cl₂                    CF_Three             SO₂CH₂SO₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂SCH₂(E11-1a)
3,5-Cl₂                    CF_Three             SCH₂SC (O) CH_Three
3,5-Cl₂                    CF_Three             SO₂CH₂SC (O) CH_Three
3,5-Cl₂                    CF_Three             SO₂CF₂SCH_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) SCH₂SO₂CH_Three
3,5-Cl₂                    CF_Three             S (O) CH (CH_Three) SCH₂SO₂CH_Three
3,5-Cl₂                    CF_Three             SO₂CH (CH_Three) SCH₂SO₂CH_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) SCH₂(E11-1a)
3,5-Cl₂                    CF_Three             SCH (CH_Three) S (E11-1a)
3,5-Cl₂                    CF_Three             SO₂CH (CH_Three) SSEt
3,5-Cl₂                    CF_Three             SC (CH_Three)₂SEt
3,5-Cl₂                    CF_Three             SO₂C (CH_Three)₂SO₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH_Three
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂SO₂CH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SEt
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂SO₂Et
3,5-Cl₂                    CF_Three             SCH₂CH₂SPr-n
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂SO₂Pr-n
3,5-Cl₂                    CF_Three             SCH₂CH₂SPr-i
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂SO₂Pr-i
3,5-Cl₂                    CF_Three             SCH₂CH₂SBu-t
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂SO₂Bu-t
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH₂CF_Three
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂SO₂CH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂SO₂CH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH₂CH₂OCH₂CF_Three
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂SO₂CH₂CH₂OCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH₂CH₂OC (O) CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH₂CH₂SCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH₂CH₂SCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH₂Si (CH_Three)_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH₂C (O) CH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH₂CH₂C (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂CH₂CH₂C (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH₂C (O) N (Et)₂
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH₂CH = CH₂
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH₂C≡CH
3,5-Cl₂                    CF_Three             SCH₂CH₂SCH₂Ph
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂SO₂CH₂Ph
3,5-Cl₂                    CF_Three             SCH₂CH₂SC (O) CH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SC (O) NHEt
3,5-Cl₂                    CF_Three             SCH₂CH₂SC (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂CH₂SC (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SC (S) NHCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SC (S) NHEt
3,5-Cl₂                    CF_Three             SCH₂CH₂SC (S) N (CH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂CH₂SC (S) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SPh
3,5-Cl₂                    CF_Three             SO₂CH₂CH₂SO₂Ph
3,5-Cl₂                    CF_Three             SCH₂CH₂S (D10-1a)
3,5-Cl₂                    CF_Three             SCH₂CH₂S (D32-1a)
3,5-Cl₂                    CF_Three             SCH₂CH₂S (D34-1a)
3,5-Cl₂                    CF_Three             SCH₂CH₂SSCH_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂SCH_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂SCH_Three(R)
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂SCH_Three(S)
3,5-Cl₂                    CF_Three             SO₂CH (CH_Three) CH₂SO₂CH_Three
3,5-Cl₂                    CF_Three             SC (CH_Three)₂CH₂SCH_Three
3,5-Cl₂                    CF_Three             SO₂C (CH_Three)₂CH₂SO₂CH_Three
3,5-Cl₂                    CF_Three             SCH₂(E4-1a)
3,5-Cl₂                    CF_Three             SCH₂(E4-2a)
3,5-Cl₂                    CF_Three             SO₂CH₂(E4-2c)
3,5-Cl₂                    CF_Three             S (E4-1a)
3,5-Cl₂                    CF_Three             S (E4-2a)
3,5-Cl₂                    CF_Three             SCH (CH_Three) NO₂
3,5-Cl₂                    CF_Three             SC (CH_Three)₂NO₂
3,5-Cl₂                    CF_Three             SCH₂N (CH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂NHC (O) CH_Three
3,5-Cl₂                    CF_Three             SCH₂NHC (O) Et
3,5-Cl₂                    CF_Three             SCH₂NHC (O) Pr-n
3,5-Cl₂                    CF_Three             SCH₂NHC (O) Pr-i
3,5-Cl₂                    CF_Three             SCH₂NHC (O) Bu-t
3,5-Cl₂                    CF_Three             SCH₂NHC (O) CF_Three
3,5-Cl₂                    CF_Three             SCH₂N (CH_Three) C (O) CF_Three
3,5-Cl₂                    CF_Three             SCH₂NHC (O) CF₂Cl
3,5-Cl₂                    CF_Three             SCH₂NHC (O) CH₂CHFBr
3,5-Cl₂                    CF_Three             SCH₂NHC (O) CH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂NHC (O) Ph
3,5-Cl₂                    CF_Three             SCH₂NHC (O) (D10-2a)
3,5-Cl₂                    CF_Three             SCH₂NHC (O) (D32-1a)
3,5-Cl₂                    CF_Three             SCH₂NHC (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂NHC (O) OEt
3,5-Cl₂                    CF_Three             SCH₂NHC (O) OPr-n
3,5-Cl₂                    CF_Three             SCH₂NHC (O) OPr-i
3,5-Cl₂                    CF_Three             SCH₂NHC (O) OBu-t
3,5-Cl₂                    CF_Three             SCH₂NHC (O) OCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂NHC (O) SCH_Three
3,5-Cl₂                    CF_Three             SCH₂NHC (S) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂NHC (S) SCH_Three
3,5-Cl₂                    CF_Three             SCH₂NHSO₂CH_Three
3,5-Cl₂                    CF_Three             SCH₂NHSO₂Ph
3,5-Cl₂                    CF_Three             SCH (CH_Three(T-11)
3,5-Cl₂                    CF_Three             SO₂CH (CH_Three) NHCHO
3,5-Cl₂                    CF_Three             SO₂CH (CH_Three) N (CH_Three) C (O) Ph
3,5-Cl₂                    CF_Three             SCH (CH_Three) NHC (O) OEt
3,5-Cl₂                    CF_Three             SCH (CH_Three) NHC (O) OBu-t
3,5-Cl₂                    CF_Three             SCH (CH_Three(T-13)
3,5-Cl₂                    CF_Three             SCH (CH_Three) (T-14)
3,5-Cl₂                    CF_Three             SCH (CH_Three(T-15)
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) CH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂N (CH_Three) C (O) CH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) Et
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) Pr-n
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) Pr-i
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) Pr-c
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) Bu-t
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂N (CH_Three) C (O) CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) Ph
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) (D10-2a)
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) (D32-1a)
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) OEt
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) OPr-i
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) OBu-t
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) OCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (S) NHEt
3,5-Cl₂                    CF_Three             SCH₂CH₂NHC (S) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂NHSO₂CH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂N (CH_Three) SO₂CH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂NHSO₂Et
3,5-Cl₂                    CF_Three             SCH₂CH₂NHSO₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂N (CH_Three) SO₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂NHSO₂Ph
3,5-Cl₂                    CF_Three             SCH₂CH₂NHSO₂N (CH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂CH₂NHP (S) (OCH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂CH₂NHP (S) (OEt)₂
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂NHC (O) CH_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂NHC (O) CF_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂NHC (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂NHC (O) OBu-t
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂NHC (O) OCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂NHC (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂NHC (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) CH₂NHC (O) Ph
3,5-Cl₂                    CF_Three             SC (CH_Three)₂CH₂NHC (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂(E5-1a) C (O) CH_Three
3,5-Cl₂                    CF_Three             SCH₂(E5-2a) C (O) CH_Three
3,5-Cl₂                    CF_Three             SCH₂(E5-2a) C (O) OCH_Three
3,5-Cl₂                    CF_Three             S (E5-1a) C (O) OEt
3,5-Cl₂                    CF_Three             S (E5-2a) CHO
3,5-Cl₂                    CF_Three             S (E5-2a) C (O) CH_Three
3,5-Cl₂                    CF_Three             S (E5-2a) C (O) CF_Three
3,5-Cl₂                    CF_Three             S (E5-2a) C (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂Si (CH_Three)_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) CH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) Ph
3,5-Cl₂                    CF_Three             SCH₂(M1-1a)
3,5-Cl₂                    CF_Three             SCH₂CH = NOH
3,5-Cl₂                    CF_Three             SCH₂CH = NOCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH = NOEt
3,5-Cl₂                    CF_Three             SCH₂CH = NOCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH = NOCH₂CH₂OEt
3,5-Cl₂                    CF_Three             SCH₂CH = NOCH₂CH₂SEt
3,5-Cl₂                    CF_Three             SCH₂CH = NOCH₂CN
3,5-Cl₂                    CF_Three             SCH₂CH = NOCH₂CH = CH₂
3,5-Cl₂                    CF_Three             SCH₂CH = NOCH₂C≡CH
3,5-Cl₂                    CF_Three             SCH₂CH = NOCH₂Ph
3,5-Cl₂                    CF_Three             SCH₂(M3-1a)
3,5-Cl₂                    CF_Three             SCH₂(M3-1b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂CN
3,5-Cl₂                    CF_Three             SCH₂C (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) OEt
3,5-Cl₂                    CF_Three             SCH₂CH₂C (O) OEt
3,5-Cl₂                    CF_Three             SCH₂C (O) SCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) NH₂
3,5-Cl₂                    CF_Three             S (O) CH₂C (O) NH₂
3,5-Cl₂                    CF_Three             SO₂CH₂C (O) NH₂
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH_Three
3,5-Cl₂                    CF_Three             S (O) CH₂C (O) NHCH_Three
3,5-Cl₂                    CF_Three             SO₂CH₂C (O) NHCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) NHEt
3,5-Cl₂                    CF_Three             S (O) CH₂C (O) NHEt
3,5-Cl₂                    CF_Three             SO₂CH₂C (O) NHEt
3,5-Cl₂                    CF_Three             SCH₂C (O) NHPr-n
3,5-Cl₂                    CF_Three             SCH₂C (O) NHPr-i
3,5-Cl₂                    CF_Three             S (O) CH₂C (O) NHPr-i
3,5-Cl₂                    CF_Three             SO₂CH₂C (O) NHPr-i
3,5-Cl₂                    CF_Three             SCH₂C (O) NHPr-c
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂Pr-c
3,5-Cl₂                    CF_Three             SCH₂C (O) NHBu-c
3,5-Cl₂                    CF_Three             SCH₂C (O) NHBu-t
3,5-Cl₂                    CF_Three             SCH₂C (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three             S (O) CH₂C (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three             SO₂CH₂C (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂C (O) (T-7)
3,5-Cl₂                    CF_Three             SCH₂C (O) (T-10)
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂CH₂F
3,5-Cl₂                    CF_Three             S (O) CH₂C (O) NHCH₂CH₂F
3,5-Cl₂                    CF_Three             SO₂CH₂C (O) NHCH₂CH₂F
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three             S (O) CH₂C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three             SO₂CH₂C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂OEt
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂OCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) CH_Three] CH₂OCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂(E6-1a)
3,5-Cl₂                    CF_Three             SCH₂C (O) NH (E3-1a)
3,5-Cl₂                    CF_Three             SCH₂C (O) (T-8)
3,5-Cl₂                    CF_Three             SCH₂C (O) (T-11)
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂CH₂SCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂CH₂SO₂CH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) (T-9)
3,5-Cl₂                    CF_Three             SCH₂C (O) (T-12)
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂CH = NOCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂CN
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH (CH_Three) C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH (CH_Three) C (O) NHCH₂CF_Three(D)
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂C≡CH
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂Ph
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH (CH_Three) Ph (R)
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂(D10-2a)
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) CH_Three] CH₂(D10-2a)
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) Et] CH₂(D10-2a)
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH₂(D32-1a)
3,5-Cl₂                    CF_Three             SCH₂C (O) N (CH₂OCH_Three) CH₂(D32-1a)
3,5-Cl₂                    CF_Three             SCH₂C (O) N (CH₂CN) CH₂(D32-1a)
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) CH_Three] CH₂(D32-1a)
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) Et] CH₂(D32-1a)
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) OCH_Three] CH₂(D32-1a)
3,5-Cl₂                    CF_Three             SCH₂C (O) NHN (CH_Three) Ph
3,5-Cl₂                    CF_Three             SCH₂C (O) NHN (CH_Three) (D34-1a)
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH = NOCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) NHCH = NOEt
3,5-Cl₂                    CF_Three             SCH₂C (O) NHC (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) N (Et) C (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) N (CH₂OCH_Three) C (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) N (CH₂OEt) C (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) N (CH₂OCH₂CF_Three) C (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) N (E3-1a) C (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) Et] C (O) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) NHC (O) NH₂
3,5-Cl₂                    CF_Three             SCH₂C (O) NHC (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂C (O) NH (Ph-2,4-F₂)
3,5-Cl₂                    CF_Three             SCH₂C (O) N (CH₂OCH_Three) (D32-1d) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) CH_Three] (D32-1d) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) OCH_Three] (D32-1d) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N (CH₂OCH_Three) (D32-2e) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) CH_Three] (D32-2e) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) OCH_Three] (D32-2e) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N (CH₂OCH_Three) (D33-1d) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) CH_Three] (D33-1d) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) OCH_Three] (D33-1d) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) NH (D34-1c) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N (CH₂OCH_Three) (D34-1c) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) CH_Three] (D34-1c) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) Et] (D34-1c) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) Pr-i] (D34-1c) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) OCH_Three] (D34-1c) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) NH (D34-3a)
3,5-Cl₂                    CF_Three             SCH₂C (O) N (CH₂OCH_Three) (D34-3b) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) CH_Three] (D34-3b) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) OCH_Three] (D34-3b) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N (CH₂OCH_Three) (D35-1c) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) CH_Three] (D35-1c) Cl
3,5-Cl₂                    CF_Three             SCH₂C (O) N [C (O) OCH_Three] (D35-1c) Cl
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NH₂
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHCH_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHCH_Three(D)
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHCH_Three(L)
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHEt
3,5-Cl₂                    CF_Three             S (O) CH (CH_Three) C (O) NHEt
3,5-Cl₂                    CF_Three             SO₂CH (CH_Three) C (O) NHEt
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHPr-i (D)
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHPr-c (D)
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) N (CH_Three)₂(D)
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHCH₂CH₂F
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHCH₂CH₂F (D)
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHCH₂CH₂Cl (D)
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHCH₂CF_Three(D)
3,5-Cl₂                    CF_Three             S (O) CH (CH_Three) C (O) NHCH₂CF_Three(D)
3,5-Cl₂                    CF_Three             SO₂CH (CH_Three) C (O) NHCH₂CF_Three(D)
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHCH₂C≡CH
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (O) NHCH₂C≡CH (D)
3,5-Cl₂                    CF_Three             SCH₂C (OCH_Three) = NH
3,5-Cl₂                    CF_Three             SCH₂C (OEt) = NH
3,5-Cl₂                    CF_Three             SCH₂C (OEt) = NCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (OCH₂CF_Three) = NH
3,5-Cl₂                    CF_Three             SCH₂(M7-1a)
3,5-Cl₂                    CF_Three             SCH₂(M7-1b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(M7-1c) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(M17-1a)
3,5-Cl₂                    CF_Three             SCH₂C (S) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (S) OEt
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (S) OCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (S) SCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (S) SEt
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (S) SCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (S) NH₂
3,5-Cl₂                    CF_Three             SCH₂C (S) NHCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (S) NHEt
3,5-Cl₂                    CF_Three             SCH₂C (S) NHPr-i
3,5-Cl₂                    CF_Three             SCH₂C (S) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (S) NH₂
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (S) NHCH_Three
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (S) NHEt
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (S) NHPr-i
3,5-Cl₂                    CF_Three             SCH (CH_Three) C (S) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂C (SCH_Three) = NH
3,5-Cl₂                    CF_Three             SCH₂C (SCH_Three) = NCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (SCH_Three) = NCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂(M9-1a)
3,5-Cl₂                    CF_Three             SCH₂(M9-1b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(M9-1c) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(M19-1a)
3,5-Cl₂                    CF_Three             SCH₂C (NH₂) = NH
3,5-Cl₂                    CF_Three             SCH₂(M11-1a) H
3,5-Cl₂                    CF_Three             SCH₂(M21-1a) H
3,5-Cl₂                    CF_Three             SCH₂C (NH₂) = NOH
3,5-Cl₂                    CF_Three             SCH₂C (NH₂) = NOCH_Three
3,5-Cl₂                    CF_Three             SCH₂SO₂NH₂
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH_Three
3,5-Cl₂                    CF_Three             SCH₂SO₂NHEt
3,5-Cl₂                    CF_Three             SCH₂SO₂NHPr-n
3,5-Cl₂                    CF_Three             SCH₂SO₂NHPr-i
3,5-Cl₂                    CF_Three             SCH₂SO₂NHPr-c
3,5-Cl₂                    CF_Three             SCH₂SO₂NHBu-t
3,5-Cl₂                    CF_Three             SCH₂SO₂N (CH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH₂CH₂F
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH (CH_Three) CH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH₂CH (OCH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH₂CH (E6-1a)
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH₂CH₂SO₂CH_Three
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH (CH_Three) CH₂SCH_Three
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH (CH_Three) CH₂SO₂CH_Three
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH₂CH₂CH₂SCH_Three
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH₂CH = CH₂
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH₂Ph
3,5-Cl₂                    CF_Three             SCH₂SO₂NHCH₂(D32-1a)
3,5-Cl₂                    CF_Three             SCH₂SO₂NHPh
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHEt
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHPr-n
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHPr-i
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHPr-c
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHBu-t
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂N (CH_Three)₂
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂(T-7)
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂(T-10)
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHCH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂(T-11)
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHCH₂CH₂SCH_Three
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂(T-12)
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHCH₂CH = CH₂
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHCH₂Ph
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHCH₂(D32-1a)
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHCH₂(D32-2a)
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHCH₂(D32-3a)
3,5-Cl₂                    CF_Three             SCH₂CH₂SO₂NHPh
3,5-Cl₂                    CF_Three             SCH₂CH = CH₂
3,5-Cl₂                    CF_Three             S (O) CH₂CH = CH₂
3,5-Cl₂                    CF_Three             SO₂CH₂CH = CH₂
3,5-Cl₂                    CF_Three             SCH₂CH = CHCH_Three
3,5-Cl₂                    CF_Three             SCH₂C (CH_Three) = CH₂
3,5-Cl₂                    CF_Three             SCF = CF₂
3,5-Cl₂                    CF_Three             SCH₂C (F) = CH₂
3,5-Cl₂                    CF_Three             SCH₂CH = CHCl
3,5-Cl₂                    CF_Three             SCH₂CCl = CH₂
3,5-Cl₂                    CF_Three             SCH₂CH = CHBr
3,5-Cl₂                    CF_Three             SCH₂CBr = CH₂
3,5-Cl₂                    CF_Three             SCH₂CH = CF₂
3,5-Cl₂                    CF_Three             SCH₂CF = CF₂
3,5-Cl₂                    CF_Three             SCH₂C (OCH_Three) = CH₂
3,5-Cl₂                    CF_Three             SCH₂C≡CH
3,5-Cl₂                    CF_Three             S (O) CH₂C≡CH
3,5-Cl₂                    CF_Three             SO₂CH₂C≡CH
3,5-Cl₂                    CF_Three             SCH (CH_Three) C≡CH
3,5-Cl₂                    CF_Three             SCH₂C≡CCl
3,5-Cl₂                    CF_Three             SCH₂C≡CBr
3,5-Cl₂                    CF_Three             SCH₂C≡CI
3,5-Cl₂                    CF_Three             SCH₂Ph
3,5-Cl₂                    CF_Three             SCH₂(Ph-2-F)
3,5-Cl₂                    CF_Three             SCH₂(Ph-3-F)
3,5-Cl₂                    CF_Three             SCH₂(Ph-4-F)
3,5-Cl₂                    CF_Three             SCH₂(Ph-4-OCH_Three)
3,5-Cl₂                    CF_Three             SCH₂(Ph-3-NO₂)
3,5-Cl₂                    CF_Three             SCH₂(Ph-4-NO₂)
3,5-Cl₂                    CF_Three             SCH₂(Ph-3-CN)
3,5-Cl₂                    CF_Three             SCH₂(Ph-4-CN)
3,5-Cl₂                    CF_Three             SCH₂(Ph-3,4-F₂)
3,5-Cl₂                    CF_Three             SCH (CH_Three) Ph
3,5-Cl₂                    CF_Three             SCH (CH_Three) Ph (R)
3,5-Cl₂                    CF_Three             SCH (CH_Three) Ph (S)
3,5-Cl₂                    CF_Three             SCH₂(D1-1a)
3,5-Cl₂                    CF_Three             SCH₂(D1-2a)
3,5-Cl₂                    CF_Three             SCH₂(D2-1a)
3,5-Cl₂                    CF_Three             SCH₂(D2-2a)
3,5-Cl₂                    CF_Three             SCH₂(D5-1a)
3,5-Cl₂                    CF_Three             SCH₂(D5-1c) Cl
3,5-Cl₂                    CF_Three             SCH₂(D5-1c) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D5-3a)
3,5-Cl₂                    CF_Three             SCH₂(D5-3b) Cl
3,5-Cl₂                    CF_Three             SCH₂(D5-3b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D6-1a)
3,5-Cl₂                    CF_Three             SCH₂(D6-1c) Cl
3,5-Cl₂                    CF_Three             SCH₂(D6-3a)
3,5-Cl₂                    CF_Three             SCH₂(D7-1a)
3,5-Cl₂                    CF_Three             SCH₂(D7-1b) Cl
3,5-Cl₂                    CF_Three             SCH₂(D7-1b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D7-1c) Cl
3,5-Cl₂                    CF_Three             SCH₂(D7-1c) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D8-1a) CH_Three
3,5-Cl₂                    CF_Three             SCH₂(D8-3a) CH_Three
3,5-Cl₂                    CF_Three             SCH₂(D8-3b) Cl
3,5-Cl₂                    CF_Three             SCH₂(D8-3b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D9-1a)
3,5-Cl₂                    CF_Three             SCH₂(D9-2a)
3,5-Cl₂                    CF_Three             SCH₂(D9-2b) Cl
3,5-Cl₂                    CF_Three             SCH₂(D9-2b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D9-3a)
3,5-Cl₂                    CF_Three             SCH₂(D9-3b) Cl
3,5-Cl₂                    CF_Three             SCH₂(D9-3b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D10-1a)
3,5-Cl₂                    CF_Three             SCH₂(D10-1b) Br
3,5-Cl₂                    CF_Three             SCH₂(D10-1c) Cl
3,5-Cl₂                    CF_Three             SCH₂(D10-1c) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D10-2a)
3,5-Cl₂                    CF_Three             SCH₂(D10-2b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D10-3a)
3,5-Cl₂                    CF_Three             SCH₂(D10-3b) Cl
3,5-Cl₂                    CF_Three             SCH₂(D10-3d) Cl
3,5-Cl₂                    CF_Three             SCH₂(D11-1a)
3,5-Cl₂                    CF_Three             SCH₂(D13-1a)
3,5-Cl₂                    CF_Three             SCH₂(D13-2a)
3,5-Cl₂                    CF_Three             SCH₂(D13-2b) CH_Three
3,5-Cl₂                    CF_Three             SCH₂(D14-1a)
3,5-Cl₂                    CF_Three             SCH₂(D14-1b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D14-2a)
3,5-Cl₂                    CF_Three             SCH₂(D14-2b) Cl
3,5-Cl₂                    CF_Three             SCH₂(D14-2b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D15-1b) Cl
3,5-Cl₂                    CF_Three             SCH₂(D15-1b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D15-2a)
3,5-Cl₂                    CF_Three             SCH₂(D15-2b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D16-1a)
3,5-Cl₂                    CF_Three             SCH₂(D16-1b) Cl
3,5-Cl₂                    CF_Three             SCH₂(D16-1b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D17-1a)
3,5-Cl₂                    CF_Three             SCH₂(D17-1b) Cl
3,5-Cl₂                    CF_Three             SCH₂(D17-1b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D18-1a)
3,5-Cl₂                    CF_Three             SCH₂(D19-1a)
3,5-Cl₂                    CF_Three             SCH₂(D20-1a)
3,5-Cl₂                    CF_Three             SCH₂(D21-1a) CH_Three
3,5-Cl₂                    CF_Three             SCH₂(D22-1a)
3,5-Cl₂                    CF_Three             SCH₂(D22-1b) CF_Three
3,5-Cl₂                    CF_Three             SCH₂(D26-1a)
3,5-Cl₂                    CF_Three             SCH₂(D32-1a)
3,5-Cl₂                    CF_Three             SCH₂(D32-2a)
3,5-Cl₂                    CF_Three             SCH₂(D32-3a)
3,5-Cl₂                    CF_Three             SCH₂(D33-1a)
3,5-Cl₂                    CF_Three             SCH₂(D33-2a)
3,5-Cl₂                    CF_Three             SCH₂(D34-1a)
3,5-Cl₂                    CF_Three             SCH₂(D34-2a)
3,5-Cl₂                    CF_Three             SCH₂(D34-3a)
3,5-Cl₂                    CF_Three             SCH₂(D35-1a)
3,5-Cl₂                    CF_Three             SCH₂(D37-1a)
3,5-Cl₂                    CF_Three             SO₂OCH_Three
3,5-Cl₂                    CF_Three             SO₂OCH₂CF_Three
3,5-Cl₂                    CF_Three             SSCH_Three
3,5-Cl₂                    CF_Three             SO₂NHCH_Three
3,5-Cl₂                    CF_Three             SO₂N (CH_Three)₂
3,5-Cl₂                    CF_Three             SO₂N (CH_Three) C (O) OCH_Three
3,5-Cl₂                    CF_Three             SO₂NHCH₂Pr-c
3,5-Cl₂                    CF_Three             SO₂NHBu-c
3,5-Cl₂                    CF_Three             SO₂NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SO₂N (CH₂CF_Three) C (O) OCH_Three
3,5-Cl₂                    CF_Three             SO₂NHCH₂CH₂OCH_Three
3,5-Cl₂                    CF_Three             SO₂NHCH₂(E6-1a)
3,5-Cl₂                    CF_Three             SO₂NHCH (CH_Three) CH₂SO₂CH_Three
3,5-Cl₂                    CF_Three             SO₂NHCH₂CH = NOCH_Three
3,5-Cl₂                    CF_Three             SO₂NHCH₂C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three             SO₂NHCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SO₂NHCH (CH_Three) C (O) NHCH₂CF_Three(D)
3,5-Cl₂                    CF_Three             SO₂NHCH (CH_Three) Ph (R)
3,5-Cl₂                    CF_Three             SO₂NHCH₂(D8-3a) CH_Three
3,5-Cl₂                    CF_Three             SO₂NHCH₂(D8-3b) Cl
3,5-Cl₂                    CF_Three             SO₂NHCH₂(D10-1a)
3,5-Cl₂                    CF_Three             SO₂NHCH₂(D10-2a)
3,5-Cl₂                    CF_Three             SO₂NHCH₂(D32-1a)
3,5-Cl₂                    CF_Three             SO₂N [CH₂(D32-1a)] C (O) OCH_Three
3,5-Cl₂                    CF_Three             SO₂NHN (CH_Three) Ph
3,5-Cl₂                    CF_Three             SO₂N [C (O) OCH_Three] N (CH_Three) Ph
3,5-Cl₂                    CF_Three             SO₂N [C (O) OCH_Three] N (CH_Three) (D32-1a)
3,5-Cl₂                    CF_Three             SO₂NHN (CH_Three) (D34-1a)
3,5-Cl₂                    CF_Three             SO₂N [C (O) OCH_Three] N (CH_Three) (D34-1a)
3,5-Cl₂                    CF_Three             SO₂NHC (O) OCH_Three
3,5-Cl₂                    CF_Three             SO₂NHC (O) OEt
3,5-Cl₂                    CF_Three             SO₂NHC (O) OPr-i
3,5-Cl₂                    CF_Three             SO₂NHC (O) OBu-t
3,5-Cl₂                    CF_Three             SO₂NHC (O) OCH₂CF_Three
3,5-Cl₂                    CF_Three             SO₂NHC (O) SCH_Three
3,5-Cl₂                    CF_Three             SO₂NHC (O) NH₂
3,5-Cl₂                    CF_Three             SO₂NHC (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SO₂NHC (S) OCH_Three
3,5-Cl₂                    CF_Three             SO₂NHC (S) SCH_Three
3,5-Cl₂                    CF_Three             SO₂NHC (S) NH₂
3,5-Cl₂                    CF_Three             SO₂NH (Ph-4-F)
3,5-Cl₂                    CF_Three             SN (Ph-4-F) C (O) OCH_Three
3,5-Cl₂                    CF_Three             SO₂N (Ph-4-F) C (O) OCH_Three
3,5-Cl₂                    CF_Three             SO₂NH (Ph-4-NO₂)
3,5-Cl₂                    CF_Three             SO₂NH (Ph-4-CN)
3,5-Cl₂                    CF_Three             SO₂NH [(D6-3b) CH_Three]
3,5-Cl₂                    CF_Three             SO₂NH [(D8-1a) CH_Three]
3,5-Cl₂                    CF_Three             SO₂NH (D10-1a)
3,5-Cl₂                    CF_Three             SO₂NH (D32-1a)
3,5-Cl₂                    CF_Three             SO₂NH (D34-1a)
3,5-Cl₂                    CF_Three             SN (D34-1a) C (O) OCH_Three
3,5-Cl₂                    CF_Three             SO₂N (D34-1a) C (O) OCH_Three
3,5-Cl₂                    CF_Three             SO₂NH (D34-2a)
3,5-Cl₂                    CF_Three             SC (O) OCH_Three
3,5-Cl₂                    CF_Three             SC (O) OEt
3,5-Cl₂                    CF_Three             SC (O) OPr-i
3,5-Cl₂                    CF_Three             SC (O) SCH_Three
3,5-Cl₂                    CF_Three             SC (O) NH₂
3,5-Cl₂                    CF_Three             SC (O) NHCH_Three
3,5-Cl₂                    CF_Three             SC (O) NHEt
3,5-Cl₂                    CF_Three             SC (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three             SC (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three             SC (S) OCH_Three
3,5-Cl₂                    CF_Three             SC (S) SCH_Three
3,5-Cl₂                    CF_Three             SC (S) NH₂
3,5-Cl₂                    CF_Three             SPh
3,5-Cl₂                    CF_Three             S (O) Ph
3,5-Cl₂                    CF_Three             SO₂Ph
3,5-Cl₂                    CF_Three             S (D10-1a)
3,5-Cl₂                    CF_Three             S (O) (D10-1a)
3,5-Cl₂                    CF_Three             SO₂(D10-1a)
3,5-Cl₂                    CF_Three             S (D32-1a)
3,5-Cl₂                    CF_Three             S (O) (D32-1a)
3,5-Cl₂                    CF_Three             SO₂(D32-1a)
3,5-Cl₂                    CF_Three             S (D34-1a)
3,5-Cl₂                    CF_Three             S (O) (D34-1a)
3,5-Cl₂                    CF_Three             SO₂(D34-1a)
3,5-Cl₂                    CF_Three             S (D34-2a)
3,5-Cl₂                    CF_Three             S (O) (D34-2a)
3,5-Cl₂                    CF_Three             SO₂(D34-2a)
3,5-Cl₂                    CF₂Cl SCH_Three
3,5-Cl₂                    CF₂Cl S (O) CH_Three
3,5-Cl₂                    CF₂Cl SO₂CH_Three
3,5-Cl₂                    CF₂Cl SEt
3,5-Cl₂                    CF₂Cl S (O) Et
3,5-Cl₂                    CF₂Cl SO₂Et
3,5-Cl₂                    CF₂Cl SCH₂F
3,5-Cl₂                    CF₂Cl S (O) CH₂F
3,5-Cl₂                    CF₂Cl SO₂CH₂F
3,5-Cl₂                    CF₂Cl SCHF₂
3,5-Cl₂                    CF₂Cl S (O) CHF₂
3,5-Cl₂                    CF₂Cl SO₂CHF₂
3,5-Cl₂                    CF₂Cl SCF_Three
3,5-Cl₂                    CF₂Cl S (O) CF_Three
3,5-Cl₂                    CF₂Cl SO₂CF_Three
3,5-Cl₂                    CF₂Cl SCF₂Cl
3,5-Cl₂                    CF₂Cl S (O) CF₂Cl
3,5-Cl₂                    CF₂Cl SO₂CF₂Cl
3,5-Cl₂                    CF₂Cl SCH₂CF_Three
3,5-Cl₂                    CF₂Cl S (O) CH₂CF_Three
3,5-Cl₂                    CF₂Cl SO₂CH₂CF_Three
3,5-Cl₂                    CF₂Cl SCH₂CN
3,5-Cl₂                    CF₂Cl S (O) CH₂CN
3,5-Cl₂                    CF₂Cl SO₂CH₂CN
3,5-Cl₂                    CF₂Cl SCH₂C (O) NH₂
3,5-Cl₂                    CF₂Cl S (O) CH₂C (O) NH₂
3,5-Cl₂                    CF₂Cl SO₂CH₂C (O) NH₂
3,5-Cl₂                    CF₂Cl SCH₂C (O) NHCH_Three
3,5-Cl₂                    CF₂Cl S (O) CH₂C (O) NHCH_Three
3,5-Cl₂                    CF₂Cl SO₂CH₂C (O) NHCH_Three
3,5-Cl₂                    CF₂Cl SCH₂C (O) NHEt
3,5-Cl₂                    CF₂Cl S (O) CH₂C (O) NHEt
3,5-Cl₂                    CF₂Cl SO₂CH₂C (O) NHEt
3,5-Cl₂                    CF₂Cl SCH₂C (O) NHPr-i
3,5-Cl₂                    CF₂Cl S (O) CH₂C (O) NHPr-i
3,5-Cl₂                    CF₂Cl SO₂CH₂C (O) NHPr-i
3,5-Cl₂                    CF₂Cl SCH₂C (O) NHCH₂CH₂F
3,5-Cl₂                    CF₂Cl S (O) CH₂C (O) NHCH₂CH₂F
3,5-Cl₂                    CF₂Cl SO₂CH₂C (O) NHCH₂CH₂F
3,5-Cl₂                    CF₂Cl SCH₂C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF₂Cl S (O) CH₂C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF₂Cl SO₂CH₂C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF₂Cl SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂Cl S (O) CH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂Cl SO₂CH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CFCl₂           SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CCl_Three            SCH_Three
3,5-Cl₂                    CF₂Br SCH_Three
3,5-Cl₂                    CF₂Br S (O) CH_Three
3,5-Cl₂                    CF₂Br SO₂CH_Three
3,5-Cl₂                    CF₂Br SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CFClBr SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CFBr₂           SCH_Three
3,5-Cl₂                    CF₂I SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂CHF₂         SCH_Three
3,5-Cl₂                    CF₂CHF₂         S (O) CH_Three
3,5-Cl₂                    CF₂CHF₂         SO₂CH_Three
3,5-Cl₂                    CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂CF_Three          SCH_Three
3,5-Cl₂                    CF₂CF_Three          SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂CF₂Cl SCH_Three
3,5-Cl₂                    CFClCF_Three         SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CFClCF₂Cl SCH_Three
3,5-Cl₂                    CF₂CF₂Br SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CFBrCF_Three         SCH_Three
3,5-Cl₂                    CF₂CHFCF_Three       SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂CF₂CF_Three       SCH_Three
3,5-Cl₂                    CF (CF_Three)₂        SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂CFClCF₂Cl SCH_Three
3,5-Cl₂                    CF₂CFBrCF₂Cl SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂CF₂CF₂CF_Three    SCH_Three
3,5-Cl₂                    CF (CF_ThreeCF₂CF_Three   SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CH₂OCH₂CF_Three      SCH_Three
3,5-Cl₂                    CH₂OCH (CF_Three)₂    SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂OCH_Three         SCH_Three
3,5-Cl₂                    CF₂OCH_Three         SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CH₂SCF_Three         SCH_Three
3,5-Cl₂                    CH₂CH₂SCF_Three      SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂SCH_Three         SCH_Three
3,5-Cl₂                    CF₂SEt SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂SPr-i SCH_Three
3,5-Cl₂                    CF₂SCH₂Ph SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂SPh SCH_Three
3,5-Cl₂                    CF₂CN SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂C (O) OCH_Three     SCH_Three
3,5-Cl₂                    CF₂C (O) NH₂      SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂SO₂N (CH_Three)₂   SCH_Three
3,5-Cl₂                    T-3 SCH_Three
3,5-Cl₂                    T-3 SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    T-4 SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    T-5 SCH_Three
3,5-Cl₂                    Ph SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    Ph-2-F SCH_Three
3,5-Cl₂                    Ph-3-F SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    Ph-4-F SCH_Three
3,5-Cl₂                    Ph-2-Cl SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    Ph-3-Cl SCH_Three
3,5-Cl₂                    Ph-4-Cl SCH₂C (O) NHCH₂CF_Three
3-Br-4-F CHF₂            SCH_Three
3-Br-4-F CF_Three             SCH_Three
3-Br-4-F CF_Three             S (O) CH_Three
3-Br-4-F CF_Three             SO₂CH_Three
3-Br-4-F CF_Three             SCH₂F
3-Br-4-F CF_Three             S (O) CH₂F
3-Br-4-F CF_Three             SO₂CH₂F
3-Br-4-F CF_Three             SCHF₂
3-Br-4-F CF_Three             S (O) CHF₂
3-Br-4-F CF_Three             SO₂CHF₂
3-Br-4-F CF_Three             SCF_Three
3-Br-4-F CF_Three             S (O) CF_Three
3-Br-4-F CF_Three             SO₂CF_Three
3-Br-4-F CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-4-F CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Br-4-F CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Br-4-F CF₂Cl SCH_Three
3-Br-4-F CF₂Cl S (O) CH_Three
3-Br-4-F CF₂Cl SO₂CH_Three
3-Br-4-F CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-Br-4-F CF₂Br SCH₂C (O) NHCH₂CF_Three
3-Br-4-F CF₂CHF₂         SCH_Three
2-F-4-Br CF_Three             SCH₂C (O) NHCH₂CF_Three
3-F-4-Br CF_Three             SCH_Three
2-F-5-Br CF_Three             SCH₂C (O) NHCH₂CF_Three
3-F-5-Br CHF₂            SCH_Three
3-F-5-Br CF_Three             SCH_Three
3-F-5-Br CF_Three             S (O) CH_Three
3-F-5-Br CF_Three             SO₂CH_Three
3-F-5-Br CF_Three             SCH₂F
3-F-5-Br CF_Three             S (O) CH₂F
3-F-5-Br CF_Three             SO₂CH₂F
3-F-5-Br CF_Three             SCHF₂
3-F-5-Br CF_Three             S (O) CHF₂
3-F-5-Br CF_Three             SO₂CHF₂
3-F-5-Br CF_Three             SCF_Three
3-F-5-Br CF_Three             S (O) CF_Three
3-F-5-Br CF_Three             SO₂CF_Three
3-F-5-Br CF_Three             SCH₂C (O) NHCH₂CF_Three
3-F-5-Br CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-F-5-Br CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-F-5-Br CF₂Cl SCH_Three
3-F-5-Br CF₂Cl S (O) CH_Three
3-F-5-Br CF₂Cl SO₂CH_Three
3-F-5-Br CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-F-5-Br CF₂Br SCH₂C (O) NHCH₂CF_Three
3-F-5-Br CF₂CHF₂         SCH_Three
3-Cl-5-Br CHF₂            SCH_Three
3-Cl-5-Br CHF₂            SCH₂C (O) NHCH₂CF_Three
3-Cl-5-Br CHFCl SCH₂C (O) NHCH₂CF_Three
3-Cl-5-Br CHCl₂           SCH_Three
3-Cl-5-Br CHFBr SCH₂C (O) NHCH₂CF_Three
3-Cl-5-Br CF_Three             SCH_Three
3-Cl-5-Br CF_Three             S (O) CH_Three
3-Cl-5-Br CF_Three             SO₂CH_Three
3-Cl-5-Br CF_Three             SEt
3-Cl-5-Br CF_Three             S (O) Et
3-Cl-5-Br CF_Three             SO₂Et
3-Cl-5-Br CF_Three             SCH₂F
3-Cl-5-Br CF_Three             S (O) CH₂F
3-Cl-5-Br CF_Three             SO₂CH₂F
3-Cl-5-Br CF_Three             SCHF₂
3-Cl-5-Br CF_Three             S (O) CHF₂
3-Cl-5-Br CF_Three             SO₂CHF₂
3-Cl-5-Br CF_Three             SCF_Three
3-Cl-5-Br CF_Three             S (O) CF_Three
3-Cl-5-Br CF_Three             SO₂CF_Three
3-Cl-5-Br CF_Three             SCF₂Cl
3-Cl-5-Br CF_Three             S (O) CF₂Cl
3-Cl-5-Br CF_Three             SO₂CF₂Cl
3-Cl-5-Br CF_Three             SCH₂CF_Three
3-Cl-5-Br CF_Three             S (O) CH₂CF_Three
3-Cl-5-Br CF_Three             SO₂CH₂CF_Three
3-Cl-5-Br CF_Three             SCH₂CN
3-Cl-5-Br CF_Three             S (O) CH₂CN
3-Cl-5-Br CF_Three             SO₂CH₂CN
3-Cl-5-Br CF_Three             SCH₂C (O) NH₂
3-Cl-5-Br CF_Three             S (O) CH₂C (O) NH₂
3-Cl-5-Br CF_Three             SO₂CH₂C (O) NH₂
3-Cl-5-Br CF_Three             SCH₂C (O) NHCH_Three
3-Cl-5-Br CF_Three             S (O) CH₂C (O) NHCH_Three
3-Cl-5-Br CF_Three             SO₂CH₂C (O) NHCH_Three
3-Cl-5-Br CF_Three             SCH₂C (O) NHEt
3-Cl-5-Br CF_Three             S (O) CH₂C (O) NHEt
3-Cl-5-Br CF_Three             SO₂CH₂C (O) NHEt
3-Cl-5-Br CF_Three             SCH₂C (O) NHPr-i
3-Cl-5-Br CF_Three             S (O) CH₂C (O) NHPr-i
3-Cl-5-Br CF_Three             SO₂CH₂C (O) NHPr-i
3-Cl-5-Br CF_Three             SCH₂C (O) NHCH₂CH₂F
3-Cl-5-Br CF_Three             S (O) CH₂C (O) NHCH₂CH₂F
3-Cl-5-Br CF_Three             SO₂CH₂C (O) NHCH₂CH₂F
3-Cl-5-Br CF_Three             SCH₂C (O) NHCH₂CH₂Cl
3-Cl-5-Br CF_Three             S (O) CH₂C (O) NHCH₂CH₂Cl
3-Cl-5-Br CF_Three             SO₂CH₂C (O) NHCH₂CH₂Cl
3-Cl-5-Br CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-Br CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Cl-5-Br CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂Cl SCH_Three
3-Cl-5-Br CF₂Cl S (O) CH_Three
3-Cl-5-Br CF₂Cl SO₂CH_Three
3-Cl-5-Br CF₂Cl SCH₂F
3-Cl-5-Br CF₂Cl S (O) CH₂F
3-Cl-5-Br CF₂Cl SO₂CH₂F
3-Cl-5-Br CF₂Cl SCHF₂
3-Cl-5-Br CF₂Cl S (O) CHF₂
3-Cl-5-Br CF₂Cl SO₂CHF₂
3-Cl-5-Br CF₂Cl SCF_Three
3-Cl-5-Br CF₂Cl S (O) CF_Three
3-Cl-5-Br CF₂Cl SO₂CF_Three
3-Cl-5-Br CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂Cl S (O) CH₂C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂Cl SO₂CH₂C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂Br SCH_Three
3-Cl-5-Br CF₂Br SCH₂C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂CHF₂         SCH_Three
3-Cl-5-Br CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂CF_Three          SCH_Three
3-Cl-5-Br CF₂OCH_Three         SCH₂C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂SCH_Three         SCH_Three
3-Cl-5-Br T-3 SCH₂C (O) NHCH₂CF_Three
3,4-Br₂                    CF_Three             SCH_Three
3,4-Br₂                    CF_Three             S (O) CH_Three
3,4-Br₂                    CF_Three             SO₂CH_Three
3,4-Br₂                    CF_Three             SCH₂C (O) NHCH₂CF_Three
3,4-Br₂                    CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3,4-Br₂                    CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3,4-Br₂                    CF₂Cl SCH_Three
3,4-Br₂                    CF₂Cl SCH₂C (O) NHCH₂CF_Three
3,5-Br₂                    CHF₂            SCH_Three
3,5-Br₂                    CHF₂            SCH₂C (O) NHCH₂CF_Three
3,5-Br₂                    CHFCl SCH_Three
3,5-Br₂                    CHCl₂           SCH₂C (O) NHCH₂CF_Three
3,5-Br₂                    CHFBr SCH_Three
3,5-Br₂                    CF_Three             SCH_Three
3,5-Br₂                    CF_Three             S (O) CH_Three
3,5-Br₂                    CF_Three             SO₂CH_Three
3,5-Br₂                    CF_Three             SEt
3,5-Br₂                    CF_Three             S (O) Et
3,5-Br₂                    CF_Three             SO₂Et
3,5-Br₂                    CF_Three             SCH₂F
3,5-Br₂                    CF_Three             S (O) CH₂F
3,5-Br₂                    CF_Three             SO₂CH₂F
3,5-Br₂                    CF_Three             SCHF₂
3,5-Br₂                    CF_Three             S (O) CHF₂
3,5-Br₂                    CF_Three             SO₂CHF₂
3,5-Br₂                    CF_Three             SCF_Three
3,5-Br₂                    CF_Three             S (O) CF_Three
3,5-Br₂                    CF_Three             SO₂CF_Three
3,5-Br₂                    CF_Three             SCF₂Cl
3,5-Br₂                    CF_Three             S (O) CF₂Cl
3,5-Br₂                    CF_Three             SO₂CF₂Cl
3,5-Br₂                    CF_Three             SCH₂CF_Three
3,5-Br₂                    CF_Three             S (O) CH₂CF_Three
3,5-Br₂                    CF_Three             SO₂CH₂CF_Three
3,5-Br₂                    CF_Three             SCH₂CN
3,5-Br₂                    CF_Three             S (O) CH₂CN
3,5-Br₂                    CF_Three             SO₂CH₂CN
3,5-Br₂                    CF_Three             SCH₂C (O) NH₂
3,5-Br₂                    CF_Three             S (O) CH₂C (O) NH₂
3,5-Br₂                    CF_Three             SO₂CH₂C (O) NH₂
3,5-Br₂                    CF_Three             SCH₂C (O) NHCH_Three
3,5-Br₂                    CF_Three             S (O) CH₂C (O) NHCH_Three
3,5-Br₂                    CF_Three             SO₂CH₂C (O) NHCH_Three
3,5-Br₂                    CF_Three             SCH₂C (O) NHEt
3,5-Br₂                    CF_Three             S (O) CH₂C (O) NHEt
3,5-Br₂                    CF_Three             SO₂CH₂C (O) NHEt
3,5-Br₂                    CF_Three             SCH₂C (O) NHPr-i
3,5-Br₂                    CF_Three             S (O) CH₂C (O) NHPr-i
3,5-Br₂                    CF_Three             SO₂CH₂C (O) NHPr-i
3,5-Br₂                    CF_Three             SCH₂C (O) NHCH₂CH₂F
3,5-Br₂                    CF_Three             S (O) CH₂C (O) NHCH₂CH₂F
3,5-Br₂                    CF_Three             SO₂CH₂C (O) NHCH₂CH₂F
3,5-Br₂                    CF_Three             SCH₂C (O) NHCH₂CH₂Cl
3,5-Br₂                    CF_Three             S (O) CH₂C (O) NHCH₂CH₂Cl
3,5-Br₂                    CF_Three             SO₂CH₂C (O) NHCH₂CH₂Cl
3,5-Br₂                    CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Br₂                    CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3,5-Br₂                    CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂Cl SCH_Three
3,5-Br₂                    CF₂Cl S (O) CH_Three
3,5-Br₂                    CF₂Cl SO₂CH_Three
3,5-Br₂                    CF₂Cl SCH₂F
3,5-Br₂                    CF₂Cl S (O) CH₂F
3,5-Br₂                    CF₂Cl SO₂CH₂F
3,5-Br₂                    CF₂Cl SCHF₂
3,5-Br₂                    CF₂Cl S (O) CHF₂
3,5-Br₂                    CF₂Cl SO₂CHF₂
3,5-Br₂                    CF₂Cl SCF_Three
3,5-Br₂                    CF₂Cl S (O) CF_Three
3,5-Br₂                    CF₂Cl SO₂CF_Three
3,5-Br₂                    CF₂Cl SCH₂C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂Cl S (O) CH₂C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂Cl SO₂CH₂C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂Br SCH_Three
3,5-Br₂                    CF₂Br SCH₂C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂CHF₂         SCH_Three
3,5-Br₂                    CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂CF_Three          SCH₂C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂OCH_Three         SCH_Three
3,5-Br₂                    CF₂SCH_Three         SCH₂C (O) NHCH₂CF_Three
3,5-Br₂                    T-3 SCH_Three
3-F-5-I CF_Three             SCH_Three
3-F-5-I CF_Three             S (O) CH_Three
3-F-5-I CF_Three             SO₂CH_Three
3-F-5-I CF_Three             SCH₂C (O) NHCH₂CF_Three
3-F-5-I CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-F-5-I CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-F-5-I CF₂Cl SCH_Three
3-F-5-I CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-Cl-5-I CHF₂            SCH₂C (O) NHCH₂CF_Three
3-Cl-5-I CF_Three             SCH_Three
3-Cl-5-I CF_Three             S (O) CH_Three
3-Cl-5-I CF_Three             SO₂CH_Three
3-Cl-5-I CF_Three             SCH₂F
3-Cl-5-I CF_Three             S (O) CH₂F
3-Cl-5-I CF_Three             SO₂CH₂F
3-Cl-5-I CF_Three             SCHF₂
3-Cl-5-I CF_Three             S (O) CHF₂
3-Cl-5-I CF_Three             SO₂CHF₂
3-Cl-5-I CF_Three             SCF_Three
3-Cl-5-I CF_Three             S (O) CF_Three
3-Cl-5-I CF_Three             SO₂CF_Three
3-Cl-5-I CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-I CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Cl-5-I CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Cl-5-I CF₂Cl SCH_Three
3-Cl-5-I CF₂Cl S (O) CH_Three
3-Cl-5-I CF₂Cl SO₂CH_Three
3-Cl-5-I CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-Cl-5-I CF₂Br SCH_Three
3-Cl-5-I CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3,5-I₂                     CF_Three             SCH_Three
3,5-I₂                     CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH_Three-4-F CF_Three             SCH_Three
3-F-4-CH_Three                  CF_Three             SCH₂C (O) NHCH₂CF_Three
2-F-5-CH_Three                  CF_Three             SCH_Three
3-F-5-CH_Three                  CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH_Three-4-Cl CF_Three             SCH_Three
3-Cl-4-CH_Three                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-CH_Three                 CF_Three             SCH_Three
3-Cl-5-CH_Three                 CF_Three             S (O) CH_Three
3-Cl-5-CH_Three                 CF_Three             SO₂CH_Three
3-Cl-5-CH_Three                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-CH_Three                 CF₂Cl SCH_Three
3-CH_Three-4-Br CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-CH_Three                 CF_Three             SCH_Three
3-Br-5-CH_Three                 CF_Three             S (O) CH_Three
3-Br-5-CH_Three                 CF_Three             SO₂CH_Three
3-Br-5-CH_Three                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5- (CH_Three)₂                 CF_Three             SCH_Three
3,5- (CH_Three)₂                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-Et CF_Three             SCH_Three
3-CH_Three-5-Et CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-Pr-i CF_Three             SCH_Three
3-Br-5-Pr-i CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-Bu-t CF_Three             SCH_Three
3-Br-5-Bu-t CF_Three             SCH₂C (O) NHCH₂CF_Three
2-F-3-CF_Three                  CF_Three             SCH_Three
3-CF_Three-4-F CHF₂            SCH₂C (O) NHCH₂CF_Three
3-CF_Three-4-F CF_Three             SCH_Three
3-CF_Three-4-F CF_Three             S (O) CH_Three
3-CF_Three-4-F CF_Three             SO₂CH_Three
3-CF_Three-4-F CF_Three             SCH₂F
3-CF_Three-4-F CF_Three             S (O) CH₂F
3-CF_Three-4-F CF_Three             SO₂CH₂F
3-CF_Three-4-F CF_Three             SCHF₂
3-CF_Three-4-F CF_Three             S (O) CHF₂
3-CF_Three-4-F CF_Three             SO₂CHF₂
3-CF_Three-4-F CF_Three             SCF_Three
3-CF_Three-4-F CF_Three             S (O) CF_Three
3-CF_Three-4-F CF_Three             SO₂CF_Three
3-CF_Three-4-F CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-4-F CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-CF_Three-4-F CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-CF_Three-4-F CF₂Cl SCH_Three
3-CF_Three-4-F CF₂Cl S (O) CH_Three
3-CF_Three-4-F CF₂Cl SO₂CH_Three
3-CF_Three-4-F CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-CF_Three-4-F CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-CF_Three-4-F CF₂CHF₂         SCH_Three
3-F-4-CF_Three                  CF_Three             SCH₂C (O) NHCH₂CF_Three
2-F-5-CF_Three                  CF_Three             SCH_Three
3-F-5-CF_Three                  CHF₂            SCH₂C (O) NHCH₂CF_Three
3-F-5-CF_Three                  CF_Three             SCH_Three
3-F-5-CF_Three                  CF_Three             S (O) CH_Three
3-F-5-CF_Three                  CF_Three             SO₂CH_Three
3-F-5-CF_Three                  CF_Three             SCH₂F
3-F-5-CF_Three                  CF_Three             S (O) CH₂F
3-F-5-CF_Three                  CF_Three             SO₂CH₂F
3-F-5-CF_Three                  CF_Three             SCHF₂
3-F-5-CF_Three                  CF_Three             S (O) CHF₂
3-F-5-CF_Three                  CF_Three             SO₂CHF₂
3-F-5-CF_Three                  CF_Three             SCF_Three
3-F-5-CF_Three                  CF_Three             S (O) CF_Three
3-F-5-CF_Three                  CF_Three             SO₂CF_Three
3-F-5-CF_Three                  CF_Three             SCH₂C (O) NHCH₂CF_Three
3-F-5-CF_Three                  CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-F-5-CF_Three                  CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-F-5-CF_Three                  CF₂Cl SCH_Three
3-F-5-CF_Three                  CF₂Cl S (O) CH_Three
3-F-5-CF_Three                  CF₂Cl SO₂CH_Three
3-F-5-CF_Three                  CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-F-5-CF_Three                  CF₂Br SCH_Three
3-F-5-CF_Three                  CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CHF₂            SCH_Three
3-CF_Three-4-Cl CF_Three             SCH_Three
3-CF_Three-4-Cl CF_Three             S (O) CH_Three
3-CF_Three-4-Cl CF_Three             SO₂CH_Three
3-CF_Three-4-Cl CF_Three             SCH₂F
3-CF_Three-4-Cl CF_Three             S (O) CH₂F
3-CF_Three-4-Cl CF_Three             SO₂CH₂F
3-CF_Three-4-Cl CF_Three             SCHF₂
3-CF_Three-4-Cl CF_Three             S (O) CHF₂
3-CF_Three-4-Cl CF_Three             SO₂CHF₂
3-CF_Three-4-Cl CF_Three             SCF_Three
3-CF_Three-4-Cl CF_Three             S (O) CF_Three
3-CF_Three-4-Cl CF_Three             SO₂CF_Three
3-CF_Three-4-Cl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF₂Cl SCH_Three
3-CF_Three-4-Cl CF₂Cl S (O) CH_Three
3-CF_Three-4-Cl CF₂Cl SO₂CH_Three
3-CF_Three-4-Cl CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF₂CHF₂         SCH_Three
3-Cl-5-CF_Three                 CHF₂            SCH₂C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF_Three             SCH_Three
3-Cl-5-CF_Three                 CF_Three             S (O) CH_Three
3-Cl-5-CF_Three                 CF_Three             SO₂CH_Three
3-Cl-5-CF_Three                 CF_Three             SEt
3-Cl-5-CF_Three                 CF_Three             S (O) Et
3-Cl-5-CF_Three                 CF_Three             SO₂Et
3-Cl-5-CF_Three                 CF_Three             SCH₂F
3-Cl-5-CF_Three                 CF_Three             S (O) CH₂F
3-Cl-5-CF_Three                 CF_Three             SO₂CH₂F
3-Cl-5-CF_Three                 CF_Three             SCHF₂
3-Cl-5-CF_Three                 CF_Three             S (O) CHF₂
3-Cl-5-CF_Three                 CF_Three             SO₂CHF₂
3-Cl-5-CF_Three                 CF_Three             SCF_Three
3-Cl-5-CF_Three                 CF_Three             S (O) CF_Three
3-Cl-5-CF_Three                 CF_Three             SO₂CF_Three
3-Cl-5-CF_Three                 CF_Three             SCF₂Cl
3-Cl-5-CF_Three                 CF_Three             S (O) CF₂Cl
3-Cl-5-CF_Three                 CF_Three             SO₂CF₂Cl
3-Cl-5-CF_Three                 CF_Three             SCH₂CF_Three
3-Cl-5-CF_Three                 CF_Three             S (O) CH₂CF_Three
3-Cl-5-CF_Three                 CF_Three             SO₂CH₂CF_Three
3-Cl-5-CF_Three                 CF_Three             SCH₂C (O) NHEt
3-Cl-5-CF_Three                 CF_Three             S (O) CH₂C (O) NHEt
3-Cl-5-CF_Three                 CF_Three             SO₂CH₂C (O) NHEt
3-Cl-5-CF_Three                 CF_Three             SCH₂C (O) NHPr-i
3-Cl-5-CF_Three                 CF_Three             S (O) CH₂C (O) NHPr-i
3-Cl-5-CF_Three                 CF_Three             SO₂CH₂C (O) NHPr-i
3-Cl-5-CF_Three                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF₂Cl SCH_Three
3-Cl-5-CF_Three                 CF₂Cl S (O) CH_Three
3-Cl-5-CF_Three                 CF₂Cl SO₂CH_Three
3-Cl-5-CF_Three                 CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF₂Cl S (O) CH₂C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF₂Cl SO₂CH₂C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF₂Br SCH_Three
3-Cl-5-CF_Three                 CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CHF₂            SCH_Three
3-Br-5-CF_Three                 CF_Three             SCH_Three
3-Br-5-CF_Three                 CF_Three             S (O) CH_Three
3-Br-5-CF_Three                 CF_Three             SO₂CH_Three
3-Br-5-CF_Three                 CF_Three             SEt
3-Br-5-CF_Three                 CF_Three             S (O) Et
3-Br-5-CF_Three                 CF_Three             SO₂Et
3-Br-5-CF_Three                 CF_Three             SCH₂F
3-Br-5-CF_Three                 CF_Three             S (O) CH₂F
3-Br-5-CF_Three                 CF_Three             SO₂CH₂F
3-Br-5-CF_Three                 CF_Three             SCHF₂
3-Br-5-CF_Three                 CF_Three             S (O) CHF₂
3-Br-5-CF_Three                 CF_Three             SO₂CHF₂
3-Br-5-CF_Three                 CF_Three             SCF_Three
3-Br-5-CF_Three                 CF_Three             S (O) CF_Three
3-Br-5-CF_Three                 CF_Three             SO₂CF_Three
3-Br-5-CF_Three                 CF_Three             SCF₂Cl
3-Br-5-CF_Three                 CF_Three             S (O) CF₂Cl
3-Br-5-CF_Three                 CF_Three             SO₂CF₂Cl
3-Br-5-CF_Three                 CF_Three             SCH₂CF_Three
3-Br-5-CF_Three                 CF_Three             S (O) CH₂CF_Three
3-Br-5-CF_Three                 CF_Three             SO₂CH₂CF_Three
3-Br-5-CF_Three                 CF_Three             SCH₂C (O) NHEt
3-Br-5-CF_Three                 CF_Three             S (O) CH₂C (O) NHEt
3-Br-5-CF_Three                 CF_Three             SO₂CH₂C (O) NHEt
3-Br-5-CF_Three                 CF_Three             SCH₂C (O) NHPr-i
3-Br-5-CF_Three                 CF_Three             S (O) CH₂C (O) NHPr-i
3-Br-5-CF_Three                 CF_Three             SO₂CH₂C (O) NHPr-i
3-Br-5-CF_Three                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF₂Cl SCH_Three
3-Br-5-CF_Three                 CF₂Cl S (O) CH_Three
3-Br-5-CF_Three                 CF₂Cl SO₂CH_Three
3-Br-5-CF_Three                 CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF₂Cl S (O) CH₂C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF₂Cl SO₂CH₂C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF₂Br SCH₂C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF₂CHF₂         SCH_Three
3-CH_Three-5-CF_Three                CF_Three             SCH_Three
3-CH_Three-5-CF_Three                CF_Three             S (O) CH_Three
3-CH_Three-5-CF_Three                CF_Three             SO₂CH_Three
3-CH_Three-5-CF_Three                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH_Three-5-CF_Three                CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-Et-5-CF_Three                 CF_Three             SCH_Three
3-Pr-i-5-CF_Three               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Bu-t-5-CF_Three               CF_Three             SCH_Three
3,5- (CF_Three)₂                 CHF₂            SCH_Three
3,5- (CF_Three)₂                 CHF₂            SCH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CHFCl SCH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CHCl₂           SCH_Three
3,5- (CF_Three)₂                 CHFBr SCH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three             SCH_Three
3,5- (CF_Three)₂                 CF_Three             S (O) CH_Three
3,5- (CF_Three)₂                 CF_Three             SO₂CH_Three
3,5- (CF_Three)₂                 CF_Three             SEt
3,5- (CF_Three)₂                 CF_Three             S (O) Et
3,5- (CF_Three)₂                 CF_Three             SO₂Et
3,5- (CF_Three)₂                 CF_Three             SCH₂F
3,5- (CF_Three)₂                 CF_Three             S (O) CH₂F
3,5- (CF_Three)₂                 CF_Three             SO₂CH₂F
3,5- (CF_Three)₂                 CF_Three             SCHF₂
3,5- (CF_Three)₂                 CF_Three             S (O) CHF₂
3,5- (CF_Three)₂                 CF_Three             SO₂CHF₂
3,5- (CF_Three)₂                 CF_Three             SCF_Three
3,5- (CF_Three)₂                 CF_Three             S (O) CF_Three
3,5- (CF_Three)₂                 CF_Three             SO₂CF_Three
3,5- (CF_Three)₂                 CF_Three             SCF₂Cl
3,5- (CF_Three)₂                 CF_Three             S (O) CF₂Cl
3,5- (CF_Three)₂                 CF_Three             SO₂CF₂Cl
3,5- (CF_Three)₂                 CF_Three             SCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three             S (O) CH₂CF_Three
3,5- (CF_Three)₂                 CF_Three             SO₂CH₂CF_Three
3,5- (CF_Three)₂                 CF_Three             SCH₂CN
3,5- (CF_Three)₂                 CF_Three             S (O) CH₂CN
3,5- (CF_Three)₂                 CF_Three             SO₂CH₂CN
3,5- (CF_Three)₂                 CF_Three             SCH₂C (O) NH₂
3,5- (CF_Three)₂                 CF_Three             S (O) CH₂C (O) NH₂
3,5- (CF_Three)₂                 CF_Three             SO₂CH₂C (O) NH₂
3,5- (CF_Three)₂                 CF_Three             SCH₂C (O) NHCH_Three
3,5- (CF_Three)₂                 CF_Three             S (O) CH₂C (O) NHCH_Three
3,5- (CF_Three)₂                 CF_Three             SO₂CH₂C (O) NHCH_Three
3,5- (CF_Three)₂                 CF_Three             SCH₂C (O) NHEt
3,5- (CF_Three)₂                 CF_Three             S (O) CH₂C (O) NHEt
3,5- (CF_Three)₂                 CF_Three             SO₂CH₂C (O) NHEt
3,5- (CF_Three)₂                 CF_Three             SCH₂C (O) NHPr-i
3,5- (CF_Three)₂                 CF_Three             S (O) CH₂C (O) NHPr-i
3,5- (CF_Three)₂                 CF_Three             SO₂CH₂C (O) NHPr-i
3,5- (CF_Three)₂                 CF_Three             SCH₂C (O) NHCH₂CH₂F
3,5- (CF_Three)₂                 CF_Three             S (O) CH₂C (O) NHCH₂CH₂F
3,5- (CF_Three)₂                 CF_Three             SO₂CH₂C (O) NHCH₂CH₂F
3,5- (CF_Three)₂                 CF_Three             SCH₂C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂                 CF_Three             S (O) CH₂C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂                 CF_Three             SO₂CH₂C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂Cl SCH_Three
3,5- (CF_Three)₂                 CF₂Cl S (O) CH_Three
3,5- (CF_Three)₂                 CF₂Cl SO₂CH_Three
3,5- (CF_Three)₂                 CF₂Cl SCH₂F
3,5- (CF_Three)₂                 CF₂Cl S (O) CH₂F
3,5- (CF_Three)₂                 CF₂Cl SO₂CH₂F
3,5- (CF_Three)₂                 CF₂Cl SCHF₂
3,5- (CF_Three)₂                 CF₂Cl S (O) CHF₂
3,5- (CF_Three)₂                 CF₂Cl SO₂CHF₂
3,5- (CF_Three)₂                 CF₂Cl SCF_Three
3,5- (CF_Three)₂                 CF₂Cl S (O) CF_Three
3,5- (CF_Three)₂                 CF₂Cl SO₂CF_Three
3,5- (CF_Three)₂                 CF₂Cl SCH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂Cl S (O) CH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂Cl SO₂CH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂Br SCH_Three
3,5- (CF_Three)₂                 CF₂Br SCH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂CHF₂         SCH_Three
3,5- (CF_Three)₂                 CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂CF_Three          SCH_Three
3,5- (CF_Three)₂                 CF₂OCH_Three         SCH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂SCH_Three         SCH_Three
3,5- (CF_Three)₂                 T-3 SCH₂C (O) NHCH₂CF_Three
3-Cl-5-CF₂CF_Three              CF_Three             SCH_Three
3-Cl-5-CF₂CF_Three              CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-CF₂CF_Three              CF_Three             SCH_Three
3-Br-5-CF₂CF_Three              CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH_Three-5-CF₂CF_Three             CF_Three             SCH_Three
3-Cl-5-CF₂CF₂CF_Three           CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-CF₂CF₂CF_Three           CF_Three             SCH_Three
3-CH_Three-5-CF₂CF₂CF_Three          CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-CF (CF_Three)₂            CF_Three             SCH_Three
3-Br-5-CF (CF_Three)₂            CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH_Three-5-CF (CF_Three)₂           CF_Three             SCH_Three
3-Cl-5-CH₂OCH_Three             CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-CH₂OCH₂CF_Three          CF_Three             SCH_Three
3-Cl-5-C (CF_Three)₂OH CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-C (CF_Three)₂OH CF_Three             SCH_Three
3-CH_Three-5-C (CF_Three)₂OH CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5- [C (CF_Three)₂OH]₂           CF_Three             SCH_Three
3-Cl-5-C (CF_Three)₂OCH_Three         CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-C (CF_Three)₂OCH_Three         CF_Three             SCH_Three
3-CH_Three-5-C (CF_Three)₂OCH_Three        CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5- [C (CF_Three)₂OCH_Three]₂         CF_Three             SCH_Three
3-CF_Three-5-CH₂SCH_Three            CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-CH₂S (O) CH_Three         CF_Three             SCH_Three
3-CF_Three-5-CH₂SO₂CH_Three          CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-4-OCH_Three                CF_Three             SCH_Three
3-Cl-5-OCH_Three                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-OCH_Three                CF_Three             SCH_Three
3-CF_Three-5-OCH_Three               CF_Three             SCH_Three
3-CF_Three-5-OCH_Three               CF_Three             S (O) CH_Three
3-CF_Three-5-OCH_Three               CF_Three             SO₂CH_Three
3-CF_Three-5-OCH_Three               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-OCH_Three               CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-F-4-OCHF₂                CF_Three             SCH_Three
3-Cl-4-OCHF₂               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CHF₂            SCH_Three
3-Cl-5-OCHF₂               CF_Three             SCH_Three
3-Cl-5-OCHF₂               CF_Three             S (O) CH_Three
3-Cl-5-OCHF₂               CF_Three             SO₂CH_Three
3-Cl-5-OCHF₂               CF_Three             SCH₂F
3-Cl-5-OCHF₂               CF_Three             S (O) CH₂F
3-Cl-5-OCHF₂               CF_Three             SO₂CH₂F
3-Cl-5-OCHF₂               CF_Three             SCHF₂
3-Cl-5-OCHF₂               CF_Three             S (O) CHF₂
3-Cl-5-OCHF₂               CF_Three             SO₂CHF₂
3-Cl-5-OCHF₂               CF_Three             SCF_Three
3-Cl-5-OCHF₂               CF_Three             S (O) CF_Three
3-Cl-5-OCHF₂               CF_Three             SO₂CF_Three
3-Cl-5-OCHF₂               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CF₂Cl SCH_Three
3-Cl-5-OCHF₂               CF₂Cl S (O) CH_Three
3-Cl-5-OCHF₂               CF₂Cl SO₂CH_Three
3-Cl-5-OCHF₂               CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CF₂Br SCH₂C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CF₂CHF₂         SCH_Three
3-Br-4-OCHF₂               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-OCHF₂               CF_Three             SCH_Three
3-Br-5-OCHF₂               CF_Three             S (O) CH_Three
3-Br-5-OCHF₂               CF_Three             SO₂CH_Three
3-Br-5-OCHF₂               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-OCHF₂               CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Br-5-OCHF₂               CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Br-5-OCHF₂               CF₂Cl SCH_Three
3-Br-5-OCHF₂               CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-CH_Three-5-OCHF₂              CF_Three             SCH_Three
3-CF_Three-5-OCHF₂              CF_Three             SCH_Three
3-CF_Three-5-OCHF₂              CF_Three             S (O) CH_Three
3-CF_Three-5-OCHF₂              CF_Three             SO₂CH_Three
3-CF_Three-5-OCHF₂              CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-OCHF₂              CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-CF_Three-5-OCHF₂              CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-CF_Three-5-OCHF₂              CF₂Cl SCH_Three
3-CF_Three-5-OCHF₂              CF₂Cl SCH₂C (O) NHCH₂CF_Three
3,5- (OCHF₂)₂               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-F-4-OCF_Three                 CF_Three             SCH_Three
3-Cl-4-OCF_Three                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CHF₂            SCH_Three
3-Cl-5-OCF_Three                CF_Three             SCH_Three
3-Cl-5-OCF_Three                CF_Three             S (O) CH_Three
3-Cl-5-OCF_Three                CF_Three             SO₂CH_Three
3-Cl-5-OCF_Three                CF_Three             SCH₂F
3-Cl-5-OCF_Three                CF_Three             S (O) CH₂F
3-Cl-5-OCF_Three                CF_Three             SO₂CH₂F
3-Cl-5-OCF_Three                CF_Three             SCHF₂
3-Cl-5-OCF_Three                CF_Three             S (O) CHF₂
3-Cl-5-OCF_Three                CF_Three             SO₂CHF₂
3-Cl-5-OCF_Three                CF_Three             SCF_Three
3-Cl-5-OCF_Three                CF_Three             S (O) CF_Three
3-Cl-5-OCF_Three                CF_Three             SO₂CF_Three
3-Cl-5-OCF_Three                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CF₂Cl SCH_Three
3-Cl-5-OCF_Three                CF₂Cl S (O) CH_Three
3-Cl-5-OCF_Three                CF₂Cl SO₂CH_Three
3-Cl-5-OCF_Three                CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CF₂Br SCH₂C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CF₂CHF₂         SCH_Three
3-Br-4-OCF_Three                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-OCF_Three                CF_Three             SCH_Three
3-Br-5-OCF_Three                CF_Three             S (O) CH_Three
3-Br-5-OCF_Three                CF_Three             SO₂CH_Three
3-Br-5-OCF_Three                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-OCF_Three                CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Br-5-OCF_Three                CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Br-5-OCF_Three                CF₂Cl SCH_Three
3-Br-5-OCF_Three                CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-CH_Three-5-OCF_Three               CF_Three             SCH_Three
3-CF_Three-5-OCF_Three               CF_Three             SCH_Three
3-CF_Three-5-OCF_Three               CF_Three             S (O) CH_Three
3-CF_Three-5-OCF_Three               CF_Three             SO₂CH_Three
3-CF_Three-5-OCF_Three               CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-OCF_Three               CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-CF_Three-5-OCF_Three               CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-CF_Three-5-OCF_Three               CF₂Cl SCH_Three
3-CF_Three-5-OCF_Three               CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-F-5-OCF₂Br CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-OCF₂Br CF_Three             SCH_Three
3-CH_Three-5-OCF₂Br CF_Three             SCH₂C (O) NHCH₂CF_Three
3-F-5-OCF₂CHF₂             CF_Three             SCH_Three
3-Cl-5-OCF₂CHF₂            CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH_Three-5-OCF₂CHF₂           CF_Three             SCH_Three
3-F-5-OCF₂CHFCl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-OCF₂CHFCl CF_Three             SCH_Three
3-Br-5-OCF₂CHFCl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-F-5-OCF₂CHFCF_Three           CF_Three             SCH_Three
3-Cl-5-OCF₂CHFCF_Three          CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH_Three-5-OCF₂CHFCF_Three         CF_Three             SCH_Three
3-F-5-OCF₂CHFOCF_Three          CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-OCF₂CHFOCF_Three         CF_Three             SCH_Three
3-CH_Three-5-OCF₂CHFOCF_Three        CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF₂OCF₂O-4 CF_Three             SCH_Three
3-OCF₂O-4 CF_Three             SCH₂C (O) NHCH₂CF_Three
3-OCF₂CF₂O-4 CF_Three             SCH_Three
3-Cl-5-SCH_Three                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-S (O) CH_Three             CF_Three             SCH_Three
3-Cl-5-SO₂CH_Three              CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-SCH_Three                CF_Three             SCH_Three
3-Br-5-S (O) CH_Three             CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-SO₂CH_Three              CF_Three             SCH_Three
3-Cl-5-SCF_Three                CHF₂            SCH₂C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF_Three             SCH_Three
3-Cl-5-SCF_Three                CF_Three             S (O) CH_Three
3-Cl-5-SCF_Three                CF_Three             SO₂CH_Three
3-Cl-5-SCF_Three                CF_Three             SCH₂F
3-Cl-5-SCF_Three                CF_Three             S (O) CH₂F
3-Cl-5-SCF_Three                CF_Three             SO₂CH₂F
3-Cl-5-SCF_Three                CF_Three             SCHF₂
3-Cl-5-SCF_Three                CF_Three             S (O) CHF₂
3-Cl-5-SCF_Three                CF_Three             SO₂CHF₂
3-Cl-5-SCF_Three                CF_Three             SCF_Three
3-Cl-5-SCF_Three                CF_Three             S (O) CF_Three
3-Cl-5-SCF_Three                CF_Three             SO₂CF_Three
3-Cl-5-SCF_Three                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF₂Cl SCH_Three
3-Cl-5-SCF_Three                CF₂Cl S (O) CH_Three
3-Cl-5-SCF_Three                CF₂Cl SO₂CH_Three
3-Cl-5-SCF_Three                CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF₂Br SCH_Three
3-Cl-5-SCF_Three                CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3-Cl-5-S (O) CF_Three             CF_Three             SCH_Three
3-Cl-5-S (O) CF_Three             CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-SO₂CF_Three              CF_Three             SCH_Three
3-Cl-5-SO₂CF_Three              CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-SCF_Three                CF_Three             SCH_Three
3-Br-5-SCF_Three                CF_Three             S (O) CH_Three
3-Br-5-SCF_Three                CF_Three             SO₂CH_Three
3-Br-5-SCF_Three                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-SCF_Three                CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Br-5-SCF_Three                CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Br-5-SCF_Three                CF₂Cl SCH_Three
3-Br-5-SCF_Three                CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-Br-5-S (O) CF_Three             CF_Three             SCH_Three
3-Br-5-S (O) CF_Three             CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-SO₂CF_Three              CF_Three             SCH_Three
3-Br-5-SO₂CF_Three              CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-SCF₂CHFCl CF_Three             SCH_Three
3-Cl-5-SCF₂CHFCl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-S (O) CF₂CHFCl CF_Three             SCH_Three
3-Cl-5-SO₂CF₂CHFCl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-SCF₂CHFCl CF_Three             SCH_Three
3-Br-5-SCF₂CHFCl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-S (O) CF₂CHFCl CF_Three             SCH_Three
3-Br-5-SO₂CF₂CHFCl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-SPh CF_Three             SCH_Three
3-Cl-5-S (O) Ph CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-SO₂Ph CF_Three             SCH_Three
3-NO₂-4-F CF_Three             SCH₂C (O) NHCH₂CF_Three
2-F-5-NO₂                  CF_Three             SCH_Three
3-F-5-NO₂                  CF_Three             SCH₂C (O) NHCH₂CF_Three
3-NO₂-4-Cl CF_Three             SCH_Three
3-Cl-5-NO₂                 CF_Three             SCH_Three
3-Cl-5-NO₂                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-NO₂                 CF_Three             SCH_Three
3-Br-5-NO₂                 CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH_Three-5-NO₂                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-4-NO₂                CF_Three             SCH_Three
3-CF_Three-5-NO₂                CF_Three             SCH_Three
3-CF_Three-5-NO₂                CF_Three             S (O) CH_Three
3-CF_Three-5-NO₂                CF_Three             SO₂CH_Three
3-CF_Three-5-NO₂                CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-NO₂                CF₂Cl SCH₂C (O) NHCH₂CF_Three
3,5- (NO₂)₂                 CF_Three             SCH_Three
3-Cl-5-NHC (O) CF_Three           CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-N (CH_Three) C (O) CF_Three       CF_Three             SCH_Three
3-Cl-5-N (Et) C (O) CF_Three        CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-N (CH_Three) C (O) CF₂Cl CF_Three             SCH_Three
3-Cl-5-N (Et) C (O) CF₂Cl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-N (CH_Three) C (O) CF₂Br CF_Three             SCH_Three
3-Cl-5-N (Et) C (O) CF₂Br CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-N (CH_Three) SO₂CF_Three        CF_Three             SCH_Three
3-Cl-5-N (Et) SO₂CF_Three         CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-NHC (O) CH_Three          CF_Three             SCH_Three
3-CF_Three-5-NHC (O) CF_Three          CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-N (CH_Three) C (O) CH_Three      CF_Three             SCH_Three
3-CF_Three-5-N (Et) C (O) CH_Three       CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-N (CH_Three) C (O) CF_Three      CF_Three             SCH_Three
3-CF_Three-5-N (Et) C (O) CF_Three       CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-N (CH_Three) C (O) CF₂Cl CF_Three             SCH_Three
3-CF_Three-5-N (Et) C (O) CF₂Cl CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-N (CH_Three) C (O) CF₂Br CF_Three             SCH_Three
3-CF_Three-5-N (Et) C (O) CF₂Br CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-N (CH_Three) SO₂CF_Three       CF_Three             SCH_Three
3-CF_Three-5-N (Et) SO₂CF_Three        CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CN-4-F CF_Three             SCH_Three
3-F-4-CN CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-4-CN CF_Three             SCH_Three
3-F-5-CN CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-CN CF_Three             SCH_Three
3-Cl-5-CN CF_Three             S (O) CH_Three
3-Cl-5-CN CF_Three             SO₂CH_Three
3-Cl-5-CN CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-CN CF_Three             SCH_Three
3-Br-5-CN CF_Three             S (O) CH_Three
3-Br-5-CN CF_Three             SO₂CH_Three
3-Br-5-CN CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH_Three-5-CN CF_Three             SCH_Three
3-CF_Three-5-CN CF_Three             SCH_Three
3-CF_Three-5-CN CF_Three             S (O) CH_Three
3-CF_Three-5-CN CF_Three             SO₂CH_Three
3-CF_Three-5-CN CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-CN CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-CF_Three-5-CN CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-CF_Three-5-CN CF₂Cl SCH_Three
3-CF_Three-5-CN CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-NO₂-5-CN CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5- (CN)₂                  CF_Three             SCH_Three
3-Cl-5-C (O) OCH_Three            CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-C (O) NH₂             CF_Three             SCH_Three
3-Cl-5-C (O) NHCH_Three           CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-C (O) N (CH_Three)₂         CF_Three             SCH_Three
3-Br-5-C (O) OCH_Three            CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-C (O) NH₂             CF_Three             SCH_Three
3-Br-5-C (O) NHCH_Three           CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Br-5-C (O) N (CH_Three)₂         CF_Three             SCH_Three
3-CF_Three-5-C (O) OCH_Three           CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-C (O) NH₂            CF_Three             SCH_Three
3-CF_Three-5-C (O) NHCH_Three          CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CF_Three-5-C (O) N (CH_Three)₂        CF_Three             SCH_Three
3-Cl-5-SO₂OCH_Three             CF_Three             SCH₂C (O) NHCH₂CF_Three
3-CH_Three-5-SO₂OCH_Three            CF_Three             SCH_Three
3-Cl-5-SO₂NH₂              CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-SO₂NHCH_Three            CF_Three             SCH_Three
3-Cl-5-SO₂N (CH_Three)₂          CF_Three             SCH₂C (O) NHCH₂CF_Three
2-CH = CHCH = CH-3 CF_Three             SCH_Three
3-CH = CHCH = CH-4 CF_Three             SCH₂C (O) NHCH₂CF_Three
2,3,4-F_Three                   CF_Three             SCH_Three
2,3,5-F_Three                   CF_Three             SCH₂C (O) NHCH₂CF_Three
2,3,6-F_Three                   CF_Three             SCH_Three
2,4,5-F_Three                   CF_Three             SCH₂C (O) NHCH₂CF_Three
3,4,5-F_Three                   CF_Three             SCH_Three
3,4,5-F_Three                   CF_Three             S (O) CH_Three
3,4,5-F_Three                   CF_Three             SO₂CH_Three
3,4,5-F_Three                   CF_Three             SCH₂C (O) NHCH₂CF_Three
3,4,5-F_Three                   CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3,4,5-F_Three                   CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3,4,5-F_Three                   CF₂Cl SCH_Three
3,4,5-F_Three                   CF₂Cl SCH₂C (O) NHCH₂CF_Three
2,6-F₂-3-Cl CF_Three             SCH_Three
3,5-Cl₂-4-F CHF₂            SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF_Three             SCH_Three
3,5-Cl₂-4-F CF_Three             S (O) CH_Three
3,5-Cl₂-4-F CF_Three             SO₂CH_Three
3,5-Cl₂-4-F CF_Three             SEt
3,5-Cl₂-4-F CF_Three             S (O) Et
3,5-Cl₂-4-F CF_Three             SO₂Et
3,5-Cl₂-4-F CF_Three             SCH₂F
3,5-Cl₂-4-F CF_Three             S (O) CH₂F
3,5-Cl₂-4-F CF_Three             SO₂CH₂F
3,5-Cl₂-4-F CF_Three             SCHF₂
3,5-Cl₂-4-F CF_Three             S (O) CHF₂
3,5-Cl₂-4-F CF_Three             SO₂CHF₂
3,5-Cl₂-4-F CF_Three             SCF_Three
3,5-Cl₂-4-F CF_Three             S (O) CF_Three
3,5-Cl₂-4-F CF_Three             SO₂CF_Three
3,5-Cl₂-4-F CF_Three             SCF₂Cl
3,5-Cl₂-4-F CF_Three             S (O) CF₂Cl
3,5-Cl₂-4-F CF_Three             SO₂CF₂Cl
3,5-Cl₂-4-F CF_Three             SCH₂CF_Three
3,5-Cl₂-4-F CF_Three             S (O) CH₂CF_Three
3,5-Cl₂-4-F CF_Three             SO₂CH₂CF_Three
3,5-Cl₂-4-F CF_Three             SCH₂C (O) NHEt
3,5-Cl₂-4-F CF_Three             S (O) CH₂C (O) NHEt
3,5-Cl₂-4-F CF_Three             SO₂CH₂C (O) NHEt
3,5-Cl₂-4-F CF_Three             SCH₂C (O) NHPr-i
3,5-Cl₂-4-F CF_Three             S (O) CH₂C (O) NHPr-i
3,5-Cl₂-4-F CF_Three             SO₂CH₂C (O) NHPr-i
3,5-Cl₂-4-F CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF₂Cl SCH_Three
3,5-Cl₂-4-F CF₂Cl S (O) CH_Three
3,5-Cl₂-4-F CF₂Cl SO₂CH_Three
3,5-Cl₂-4-F CF₂Cl SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF₂Cl S (O) CH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF₂Cl SO₂CH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF₂Br SCH_Three
3,5-Cl₂-4-F CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CHF₂            SCH_Three
3,4,5-Cl_Three                  CHF₂            SCH₂C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CHFCl SCH_Three
3,4,5-Cl_Three                  CHCl₂           SCH₂C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CHFBr SCH_Three
3,4,5-Cl_Three                  CF_Three             SCH_Three
3,4,5-Cl_Three                  CF_Three             S (O) CH_Three
3,4,5-Cl_Three                  CF_Three             SO₂CH_Three
3,4,5-Cl_Three                  CF_Three             SEt
3,4,5-Cl_Three                  CF_Three             S (O) Et
3,4,5-Cl_Three                  CF_Three             SO₂Et
3,4,5-Cl_Three                  CF_Three             SCH₂F
3,4,5-Cl_Three                  CF_Three             S (O) CH₂F
3,4,5-Cl_Three                  CF_Three             SO₂CH₂F
3,4,5-Cl_Three                  CF_Three             SCHF₂
3,4,5-Cl_Three                  CF_Three             S (O) CHF₂
3,4,5-Cl_Three                  CF_Three             SO₂CHF₂
3,4,5-Cl_Three                  CF_Three             SCF_Three
3,4,5-Cl_Three                  CF_Three             S (O) CF_Three
3,4,5-Cl_Three                  CF_Three             SO₂CF_Three
3,4,5-Cl_Three                  CF_Three             SCF₂Cl
3,4,5-Cl_Three                  CF_Three             S (O) CF₂Cl
3,4,5-Cl_Three                  CF_Three             SO₂CF₂Cl
3,4,5-Cl_Three                  CF_Three             SCH₂CF_Three
3,4,5-Cl_Three                  CF_Three             S (O) CH₂CF_Three
3,4,5-Cl_Three                  CF_Three             SO₂CH₂CF_Three
3,4,5-Cl_Three                  CF_Three             SCH₂CN
3,4,5-Cl_Three                  CF_Three             S (O) CH₂CN
3,4,5-Cl_Three                  CF_Three             SO₂CH₂CN
3,4,5-Cl_Three                  CF_Three             SCH₂C (O) NH₂
3,4,5-Cl_Three                  CF_Three             S (O) CH₂C (O) NH₂
3,4,5-Cl_Three                  CF_Three             SO₂CH₂C (O) NH₂
3,4,5-Cl_Three                  CF_Three             SCH₂C (O) NHCH_Three
3,4,5-Cl_Three                  CF_Three             S (O) CH₂C (O) NHCH_Three
3,4,5-Cl_Three                  CF_Three             SO₂CH₂C (O) NHCH_Three
3,4,5-Cl_Three                  CF_Three             SCH₂C (O) NHEt
3,4,5-Cl_Three                  CF_Three             S (O) CH₂C (O) NHEt
3,4,5-Cl_Three                  CF_Three             SO₂CH₂C (O) NHEt
3,4,5-Cl_Three                  CF_Three             SCH₂C (O) NHPr-i
3,4,5-Cl_Three                  CF_Three             S (O) CH₂C (O) NHPr-i
3,4,5-Cl_Three                  CF_Three             SO₂CH₂C (O) NHPr-i
3,4,5-Cl_Three                  CF_Three             SCH₂C (O) NHCH₂CH₂F
3,4,5-Cl_Three                  CF_Three             S (O) CH₂C (O) NHCH₂CH₂F
3,4,5-Cl_Three                  CF_Three             SO₂CH₂C (O) NHCH₂CH₂F
3,4,5-Cl_Three                  CF_Three             SCH₂C (O) NHCH₂CH₂Cl
3,4,5-Cl_Three                  CF_Three             S (O) CH₂C (O) NHCH₂CH₂Cl
3,4,5-Cl_Three                  CF_Three             SO₂CH₂C (O) NHCH₂CH₂Cl
3,4,5-Cl_Three                  CF_Three             SCH₂C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂Cl SCH_Three
3,4,5-Cl_Three                  CF₂Cl S (O) CH_Three
3,4,5-Cl_Three                  CF₂Cl SO₂CH_Three
3,4,5-Cl_Three                  CF₂Cl SCH₂F
3,4,5-Cl_Three                  CF₂Cl S (O) CH₂F
3,4,5-Cl_Three                  CF₂Cl SO₂CH₂F
3,4,5-Cl_Three                  CF₂Cl SCHF₂
3,4,5-Cl_Three                  CF₂Cl S (O) CHF₂
3,4,5-Cl_Three                  CF₂Cl SO₂CHF₂
3,4,5-Cl_Three                  CF₂Cl SCF_Three
3,4,5-Cl_Three                  CF₂Cl S (O) CF_Three
3,4,5-Cl_Three                  CF₂Cl SO₂CF_Three
3,4,5-Cl_Three                  CF₂Cl SCH₂C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂Cl S (O) CH₂C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂Cl SO₂CH₂C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂Br SCH_Three
3,4,5-Cl_Three                  CF₂Br SCH₂C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂CHF₂         SCH_Three
3,4,5-Cl_Three                  CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂CF_Three          SCH₂C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂OCH_Three         SCH_Three
3,4,5-Cl_Three                  CF₂SCH_Three         SCH₂C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  T-3 SCH_Three
3,5-Br₂-4-F CHF₂            SCH₂C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF_Three             SCH_Three
3,5-Br₂-4-F CF_Three             S (O) CH_Three
3,5-Br₂-4-F CF_Three             SO₂CH_Three
3,5-Br₂-4-F CF_Three             SEt
3,5-Br₂-4-F CF_Three             S (O) Et
3,5-Br₂-4-F CF_Three             SO₂Et
3,5-Br₂-4-F CF_Three             SCH₂F
3,5-Br₂-4-F CF_Three             S (O) CH₂F
3,5-Br₂-4-F CF_Three             SO₂CH₂F
3,5-Br₂-4-F CF_Three             SCHF₂
3,5-Br₂-4-F CF_Three             S (O) CHF₂
3,5-Br₂-4-F CF_Three             SO₂CHF₂
3,5-Br₂-4-F CF_Three             SCF_Three
3,5-Br₂-4-F CF_Three             S (O) CF_Three
3,5-Br₂-4-F CF_Three             SO₂CF_Three
3,5-Br₂-4-F CF_Three             SCF₂Cl
3,5-Br₂-4-F CF_Three             S (O) CF₂Cl
3,5-Br₂-4-F CF_Three             SO₂CF₂Cl
3,5-Br₂-4-F CF_Three             SCH₂CF_Three
3,5-Br₂-4-F CF_Three             S (O) CH₂CF_Three
3,5-Br₂-4-F CF_Three             SO₂CH₂CF_Three
3,5-Br₂-4-F CF_Three             SCH₂C (O) NHEt
3,5-Br₂-4-F CF_Three             S (O) CH₂C (O) NHEt
3,5-Br₂-4-F CF_Three             SO₂CH₂C (O) NHEt
3,5-Br₂-4-F CF_Three             SCH₂C (O) NHPr-i
3,5-Br₂-4-F CF_Three             S (O) CH₂C (O) NHPr-i
3,5-Br₂-4-F CF_Three             SO₂CH₂C (O) NHPr-i
3,5-Br₂-4-F CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF₂Cl SCH_Three
3,5-Br₂-4-F CF₂Cl S (O) CH_Three
3,5-Br₂-4-F CF₂Cl SO₂CH_Three
3,5-Br₂-4-F CF₂Cl SCH₂C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF₂Cl S (O) CH₂C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF₂Cl SO₂CH₂C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF₂Br SCH_Three
3,5-Br₂-4-F CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3,4,5-Br_Three                  CF_Three             SCH_Three
3,4,5-Br_Three                  CF_Three             S (O) CH_Three
3,4,5-Br_Three                  CF_Three             SO₂CH_Three
3,4,5-Br_Three                  CF_Three             SCH₂C (O) NHCH₂CF_Three
3,4,5-Br_Three                  CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3,4,5-Br_Three                  CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3,4,5-Br_Three                  CF₂Cl SCH_Three
3,4,5-Br_Three                  CF₂Cl SCH₂C (O) NHCH₂CF_Three
2,3-F₂-4-CH_Three               CF_Three             SCH_Three
3,5-F₂-4-CH_Three               CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-CH_Three              CF_Three             SCH_Three
3,5-Br₂-4-CH_Three              CF_Three             SCH₂C (O) NHCH₂CF_Three
2,3-F₂-4-CF_Three               CF_Three             SCH_Three
3,4-F₂-5-CF_Three               CHF₂            SCH₂C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF_Three             SCH_Three
3,4-F₂-5-CF_Three               CF_Three             S (O) CH_Three
3,4-F₂-5-CF_Three               CF_Three             SO₂CH_Three
3,4-F₂-5-CF_Three               CF_Three             SEt
3,4-F₂-5-CF_Three               CF_Three             S (O) Et
3,4-F₂-5-CF_Three               CF_Three             SO₂Et
3,4-F₂-5-CF_Three               CF_Three             SCH₂F
3,4-F₂-5-CF_Three               CF_Three             S (O) CH₂F
3,4-F₂-5-CF_Three               CF_Three             SO₂CH₂F
3,4-F₂-5-CF_Three               CF_Three             SCHF₂
3,4-F₂-5-CF_Three               CF_Three             S (O) CHF₂
3,4-F₂-5-CF_Three               CF_Three             SO₂CHF₂
3,4-F₂-5-CF_Three               CF_Three             SCF_Three
3,4-F₂-5-CF_Three               CF_Three             S (O) CF_Three
3,4-F₂-5-CF_Three               CF_Three             SO₂CF_Three
3,4-F₂-5-CF_Three               CF_Three             SCF₂Cl
3,4-F₂-5-CF_Three               CF_Three             S (O) CF₂Cl
3,4-F₂-5-CF_Three               CF_Three             SO₂CF₂Cl
3,4-F₂-5-CF_Three               CF_Three             SCH₂CF_Three
3,4-F₂-5-CF_Three               CF_Three             S (O) CH₂CF_Three
3,4-F₂-5-CF_Three               CF_Three             SO₂CH₂CF_Three
3,4-F₂-5-CF_Three               CF_Three             SCH₂C (O) NHEt
3,4-F₂-5-CF_Three               CF_Three             S (O) CH₂C (O) NHEt
3,4-F₂-5-CF_Three               CF_Three             SO₂CH₂C (O) NHEt
3,4-F₂-5-CF_Three               CF_Three             SCH₂C (O) NHPr-i
3,4-F₂-5-CF_Three               CF_Three             S (O) CH₂C (O) NHPr-i
3,4-F₂-5-CF_Three               CF_Three             SO₂CH₂C (O) NHPr-i
3,4-F₂-5-CF_Three               CF_Three             SCH₂C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF₂Cl SCH_Three
3,4-F₂-5-CF_Three               CF₂Cl S (O) CH_Three
3,4-F₂-5-CF_Three               CF₂Cl SO₂CH_Three
3,4-F₂-5-CF_Three               CF₂Cl SCH₂C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF₂Cl S (O) CH₂C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF₂Cl SO₂CH₂C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF₂Br SCH_Three
3,4-F₂-5-CF_Three               CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
2-F-3-Cl-5-CF_Three             CF_Three             SCH_Three
3-Cl-4-F-5-CF_Three             CHF₂            SCH₂C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three             SCH_Three
3-Cl-4-F-5-CF_Three             CF_Three             S (O) CH_Three
3-Cl-4-F-5-CF_Three             CF_Three             SO₂CH_Three
3-Cl-4-F-5-CF_Three             CF_Three             SEt
3-Cl-4-F-5-CF_Three             CF_Three             S (O) Et
3-Cl-4-F-5-CF_Three             CF_Three             SO₂Et
3-Cl-4-F-5-CF_Three             CF_Three             SCH₂F
3-Cl-4-F-5-CF_Three             CF_Three             S (O) CH₂F
3-Cl-4-F-5-CF_Three             CF_Three             SO₂CH₂F
3-Cl-4-F-5-CF_Three             CF_Three             SCHF₂
3-Cl-4-F-5-CF_Three             CF_Three             S (O) CHF₂
3-Cl-4-F-5-CF_Three             CF_Three             SO₂CHF₂
3-Cl-4-F-5-CF_Three             CF_Three             SCF_Three
3-Cl-4-F-5-CF_Three             CF_Three             S (O) CF_Three
3-Cl-4-F-5-CF_Three             CF_Three             SO₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three             SCF₂Cl
3-Cl-4-F-5-CF_Three             CF_Three             S (O) CF₂Cl
3-Cl-4-F-5-CF_Three             CF_Three             SO₂CF₂Cl
3-Cl-4-F-5-CF_Three             CF_Three             SCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three             S (O) CH₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three             SO₂CH₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three             SCH₂C (O) NHEt
3-Cl-4-F-5-CF_Three             CF_Three             S (O) CH₂C (O) NHEt
3-Cl-4-F-5-CF_Three             CF_Three             SO₂CH₂C (O) NHEt
3-Cl-4-F-5-CF_Three             CF_Three             SCH₂C (O) NHPr-i
3-Cl-4-F-5-CF_Three             CF_Three             S (O) CH₂C (O) NHPr-i
3-Cl-4-F-5-CF_Three             CF_Three             SO₂CH₂C (O) NHPr-i
3-Cl-4-F-5-CF_Three             CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF₂Cl SCH_Three
3-Cl-4-F-5-CF_Three             CF₂Cl S (O) CH_Three
3-Cl-4-F-5-CF_Three             CF₂Cl SO₂CH_Three
3-Cl-4-F-5-CF_Three             CF₂Cl SCH₂C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF₂Cl S (O) CH₂C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF₂Cl SO₂CH₂C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF₂Br SCH_Three
3-Cl-4-F-5-CF_Three             CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3,4-Cl₂-5-CF_Three              CHF₂            SCH_Three
3,4-Cl₂-5-CF_Three              CF_Three             SCH_Three
3,4-Cl₂-5-CF_Three              CF_Three             S (O) CH_Three
3,4-Cl₂-5-CF_Three              CF_Three             SO₂CH_Three
3,4-Cl₂-5-CF_Three              CF_Three             SEt
3,4-Cl₂-5-CF_Three              CF_Three             S (O) Et
3,4-Cl₂-5-CF_Three              CF_Three             SO₂Et
3,4-Cl₂-5-CF_Three              CF_Three             SCH₂F
3,4-Cl₂-5-CF_Three              CF_Three             S (O) CH₂F
3,4-Cl₂-5-CF_Three              CF_Three             SO₂CH₂F
3,4-Cl₂-5-CF_Three              CF_Three             SCHF₂
3,4-Cl₂-5-CF_Three              CF_Three             S (O) CHF₂
3,4-Cl₂-5-CF_Three              CF_Three             SO₂CHF₂
3,4-Cl₂-5-CF_Three              CF_Three             SCF_Three
3,4-Cl₂-5-CF_Three              CF_Three             S (O) CF_Three
3,4-Cl₂-5-CF_Three              CF_Three             SO₂CF_Three
3,4-Cl₂-5-CF_Three              CF_Three             SCF₂Cl
3,4-Cl₂-5-CF_Three              CF_Three             S (O) CF₂Cl
3,4-Cl₂-5-CF_Three              CF_Three             SO₂CF₂Cl
3,4-Cl₂-5-CF_Three              CF_Three             SCH₂CF_Three
3,4-Cl₂-5-CF_Three              CF_Three             S (O) CH₂CF_Three
3,4-Cl₂-5-CF_Three              CF_Three             SO₂CH₂CF_Three
3,4-Cl₂-5-CF_Three              CF_Three             SCH₂C (O) NHEt
3,4-Cl₂-5-CF_Three              CF_Three             S (O) CH₂C (O) NHEt
3,4-Cl₂-5-CF_Three              CF_Three             SO₂CH₂C (O) NHEt
3,4-Cl₂-5-CF_Three              CF_Three             SCH₂C (O) NHPr-i
3,4-Cl₂-5-CF_Three              CF_Three             S (O) CH₂C (O) NHPr-i
3,4-Cl₂-5-CF_Three              CF_Three             SO₂CH₂C (O) NHPr-i
3,4-Cl₂-5-CF_Three              CF_Three             SCH₂C (O) NHCH₂CF_Three
3,4-Cl₂-5-CF_Three              CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3,4-Cl₂-5-CF_Three              CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3,4-Cl₂-5-CF_Three              CF₂Cl SCH_Three
3,4-Cl₂-5-CF_Three              CF₂Cl S (O) CH_Three
3,4-Cl₂-5-CF_Three              CF₂Cl SO₂CH_Three
3,4-Cl₂-5-CF_Three              CF₂Cl SCH₂C (O) NHCH₂CF_Three
3,4-Cl₂-5-CF_Three              CF₂Cl S (O) CH₂C (O) NHCH₂CF_Three
3,4-Cl₂-5-CF_Three              CF₂Cl SO₂CH₂C (O) NHCH₂CF_Three
3,4-Cl₂-5-CF_Three              CF₂Br SCH₂C (O) NHCH₂CF_Three
3,4-Cl₂-5-CF_Three              CF₂CHF₂         SCH_Three
3,5- (CF_Three)₂-4-Cl CHF₂            SCH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three             SCH_Three
3,5- (CF_Three)₂-4-Cl CF_Three             S (O) CH_Three
3,5- (CF_Three)₂-4-Cl CF_Three             SO₂CH_Three
3,5- (CF_Three)₂-4-Cl CF_Three             SEt
3,5- (CF_Three)₂-4-Cl CF_Three             S (O) Et
3,5- (CF_Three)₂-4-Cl CF_Three             SO₂Et
3,5- (CF_Three)₂-4-Cl CF_Three             SCH₂F
3,5- (CF_Three)₂-4-Cl CF_Three             S (O) CH₂F
3,5- (CF_Three)₂-4-Cl CF_Three             SO₂CH₂F
3,5- (CF_Three)₂-4-Cl CF_Three             SCHF₂
3,5- (CF_Three)₂-4-Cl CF_Three             S (O) CHF₂
3,5- (CF_Three)₂-4-Cl CF_Three             SO₂CHF₂
3,5- (CF_Three)₂-4-Cl CF_Three             SCF_Three
3,5- (CF_Three)₂-4-Cl CF_Three             S (O) CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three             SO₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three             SCF₂Cl
3,5- (CF_Three)₂-4-Cl CF_Three             S (O) CF₂Cl
3,5- (CF_Three)₂-4-Cl CF_Three             SO₂CF₂Cl
3,5- (CF_Three)₂-4-Cl CF_Three             SCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three             S (O) CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three             SO₂CH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three             SCH₂C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three             S (O) CH₂C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three             SO₂CH₂C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three             SCH₂C (O) NHPr-i
3,5- (CF_Three)₂-4-Cl CF_Three             S (O) CH₂C (O) NHPr-i
3,5- (CF_Three)₂-4-Cl CF_Three             SO₂CH₂C (O) NHPr-i
3,5- (CF_Three)₂-4-Cl CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three             S (O) CH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three             SO₂CH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂Cl SCH_Three
3,5- (CF_Three)₂-4-Cl CF₂Cl S (O) CH_Three
3,5- (CF_Three)₂-4-Cl CF₂Cl SO₂CH_Three
3,5- (CF_Three)₂-4-Cl CF₂Cl SCH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂Cl S (O) CH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂Cl SO₂CH₂C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂Br SCH_Three
3,5- (CF_Three)₂-4-Cl CF₂CHF₂         SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-OH CF_Three             SCH_Three
3,5-Br₂-4-OH CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-I₂-4-OH CF_Three             SCH_Three
3,5-F₂-4-OCH_Three              CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-OCH_Three             CF_Three             SCH_Three
3-F-5-Br-4-OCH_Three            CF_Three             SCH₂C (O) NHCH₂CF_Three
3-Cl-5-Br-4-OCH_Three           CF_Three             SCH_Three
3,5-Br₂-4-OCH_Three             CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-OEt CF_Three             SCH_Three
3,5-Br₂-4-OEt CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-OPr-n CF_Three             SCH_Three
3,5-Cl₂-4-OCHF₂            CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Br₂-4-OCHF₂            CF_Three             SCH_Three
3,5-F₂-4-OCF_Three              CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-OCH₂CH = CH₂       CF_Three             SCH_Three
3,5-Cl₂-4-OCH₂C≡CH CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-OSi (CH_Three)_Three        CF_Three             SCH_Three
3,5-Cl₂-4-OSi (CH_Three)₂Bu-t CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-NH₂              CF_Three             SCH_Three
3,5-Cl₂-4-NH₂              CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Br₂-4-NH₂              CF_Three             SCH_Three
3,5-Br₂-4-NH₂              CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-I₂-4-NH₂               CF_Three             SCH_Three
3,5-F₂-4-NO₂               CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-NO₂              CF_Three             SCH_Three
3,5-F₂-4-CN CF_Three             SCH₂C (O) NHCH₂CF_Three
3,5-Cl₂-4-CN CF_Three             SCH_Three
3,5-Br₂-4-CN CF_Three             SCH₂C (O) NHCH₂CF_Three
2,3,5,6-F_Four                 CF_Three             SCH_Three
2,3,4,5,6-F_Five               CF_Three             SCH₂C (O) NHCH₂CF_Three
―――――――――――――――――――――――――――――――――――――――
Table 3
  In the table, substituent (X)_mAnd (Y)_nThe numbers representing the substitution positions correspond to the positions of the numbers described in the following structural formulas, and the symbol “-” represents no substitution.

  In addition, the substituent G in the general formulas [2] -1 and [2] -2 represents a structure represented by the following G-1 to G-22, respectively.

―――――――――――――――――――――――――――――――――――――――
G (X) _m (Y) _n S (O) _r -LQ
―――――――――――――――――――――――――――――――――――――――
G-1 3-CF ₃ 2-Pr-i SCH ₃
G-1 3-CF ₃ 2-OEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ 2-OPr-i SCH ₃
G-1 3-CF ₃ 2-OSO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ 2-NHEt SCH ₃
G-1 3-CF ₃ 2-NHPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ 2-N (CH ₃ ) ₂ SCH ₃
G-1 3-CF ₃ 2-NHC (O) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ 2-NHC (O) OCH ₃ SCH ₃
G-1 3-CF ₂ CF ₃ 2-Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₂ CF ₃ 2-OEt SCH ₃
G-1 3-CF ₂ CF ₃ 2-OPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₂ CF ₃ 2-OSO ₂ CH ₃ SCH ₃
G-1 3-CF ₂ CF ₃ 2-NHEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₂ CF ₃ 2-NHPr-i SCH ₃
G-1 3-CF ₂ CF ₃ 2-N (CH ₃ ) ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₂ CF ₃ 2-NHC (O) CH ₃ SCH ₃
G-1 3-CF ₂ CF ₃ 2-NHC (O) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-SF ₅ 2-Pr-i SCH ₃
G-1 3-SF ₅ 2-OEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-SF ₅ 2-OPr-i SCH ₃
G-1 3-SF ₅ 2-OSO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-SF ₅ 2-NHEt SCH ₃
G-1 3-SF ₅ 2-NHPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-SF ₅ 2-N (CH ₃ ) ₂ SCH ₃
G-1 3-SF ₅ 2-NHC (O) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-SF ₅ 2-NHC (O) OCH ₃ SCH ₃
G-1 3,5-Cl ₂ 3-F SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 3-Cl SCH ₃
G-1 3,5-Cl ₂ 3-Br SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 3-CH ₃ SCH ₃
G-1 3,5-Cl ₂ 3-Et SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-Pr-n SCH ₃
G-1 3,5-Cl ₂ 2-Pr-i SCH ₃
G-1 3,5-Cl ₂ 2-Pr-i S (O) CH ₃
G-1 3,5-Cl ₂ 2-Pr-i SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-Bu-n SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-Bu-s SCH ₃
G-1 3,5-Cl ₂ 2-Bu-t SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CF ₂ CF ₃ SCH ₃
G-1 3,5-Cl ₂ 2-CH ₂ OH SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₂ OCH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-CH ₂ OCH ₃ S (O) CH ₃
G-1 3,5-Cl ₂ 2-CH ₂ OCH ₃ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-CH ₂ OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₂ OEt SCH ₃
G-1 3,5-Cl ₂ 2-CH ₂ OPr-n SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₂ OPr-i SCH ₃
G-1 3,5-Cl ₂ 2-CH ₂ OPr-c SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₂ OCH ₂ CF ₃ SCH ₃
G-1 3,5-Cl ₂ 2-CH ₂ CH ₂ OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₂ SCH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-CH ₂ SCH ₃ S (O) CH ₃
G-1 3,5-Cl ₂ 2-CH ₂ SCH ₃ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-CH ₂ SCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₂ S (O) CH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-CH ₂ SO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₂ SCF ₃ SCH ₃
G-1 3,5-Cl ₂ 2-CH ₂ SCF ₃ S (O) CH ₃
G-1 3,5-Cl ₂ 2-CH ₂ SCF ₃ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-CH ₂ SCF ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₂ S (O) CF ₃ SCH ₃
G-1 3,5-Cl ₂ 2-CH ₂ SO ₂ CF ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₂ Ph SCH ₃
G-1 3,5-Cl ₂ 2-CH ₂ (D7-1a) SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₂ (D11-1a) SCH ₃
G-1 3,5-Cl ₂ 2-CH ₂ (D22-1a) SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 3-OCH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-OEt SCH ₃
G-1 3,5-Cl ₂ 2-OEt S (O) CH ₃
G-1 3,5-Cl ₂ 2-OEt SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-OEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-OPr-n SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-OPr-i SCH ₃
G-1 3,5-Cl ₂ 2-OPr-i S (O) CH ₃
G-1 3,5-Cl ₂ 2-OPr-i SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-OPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-OBu-n SCH ₃
G-1 3,5-Cl ₂ 2-OPen-n SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-OHex-n SCH ₃
G-1 3,5-Cl ₂ 2-OCF ₂ Br SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-OCF ₂ CHF ₂ SCH ₃
G-1 3,5-Cl ₂ 2-OCF ₂ CHFCl SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-OCF ₂ CHFCF ₃ SCH ₃
G-1 3,5-Cl ₂ 2-OCF ₂ CHFOCF ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-OSO ₂ CH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-OSO ₂ CH ₃ S (O) CH ₃
G-1 3,5-Cl ₂ 2-OSO ₂ CH ₃ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-OSO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-OSO ₂ Et SCH ₃
G-1 3,5-Cl ₂ 2-OSO ₂ Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-OSO ₂ CF ₃ SCH ₃
G-1 3,5-Cl ₂ 2-OPh SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-SO ₂ CH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-SO ₂ Et SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-SO ₂ Pr-n SCH ₃
G-1 3,5-Cl ₂ 2-SO ₂ Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-SO ₂ CHF ₂ SCH ₃
G-1 3,5-Cl ₂ 2-SO ₂ CF ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-SO ₂ CF ₂ Br SCH ₃
G-1 3,5-Cl ₂ 2-SO ₂ CF ₂ CHFCl SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-SO ₂ Ph SCH ₃
G-1 3,5-Cl ₂ 2-NHEt SCH ₃
G-1 3,5-Cl ₂ 2-NHEt S (O) CH ₃
G-1 3,5-Cl ₂ 2-NHEt SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-NHEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHPr-n SCH ₃
G-1 3,5-Cl ₂ 2-NHPr-n S (O) CH ₃
G-1 3,5-Cl ₂ 2-NHPr-n SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-NHPr-n SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHPr-i SCH ₃
G-1 3,5-Cl ₂ 2-NHPr-i S (O) CH ₃
G-1 3,5-Cl ₂ 2-NHPr-i SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-NHPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) ₂ SCH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) ₂ S (O) CH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) ₂ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) Et SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (Et) ₂ SCH ₃
G-1 3,5-Cl ₂ 2-NHCHO SCH ₃
G-1 3,5-Cl ₂ 2-NHCHO S (O) CH ₃
G-1 3,5-Cl ₂ 2-NHCHO SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-NHCHO SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHC (O) CH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-NHC (O) CH ₃ S (O) CH ₃
G-1 3,5-Cl ₂ 2-NHC (O) CH ₃ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-NHC (O) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHC (O) Et SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHC (O) Pr-n SCH ₃
G-1 3,5-Cl ₂ 2-NHC (O) Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHC (O) Pr-c SCH ₃
G-1 3,5-Cl ₂ 2-NHC (O) Bu-t SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHC (O) CF ₃ SCH ₃
G-1 3,5-Cl ₂ 2-NHC (O) CF ₃ S (O) CH ₃
G-1 3,5-Cl ₂ 2-NHC (O) CF ₃ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-NHC (O) CF ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHC (O) OCH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-NHC (O) OCH ₃ S (O) CH ₃
G-1 3,5-Cl ₂ 2-NHC (O) OCH ₃ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-NHC (O) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHC (O) OEt SCH ₃
G-1 3,5-Cl ₂ 2-NHC (O) SCH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-NHC (O) SCH ₃ S (O) CH ₃
G-1 3,5-Cl ₂ 2-NHC (O) SCH ₃ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-NHC (O) SCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHC (O) SEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHC (S) OCH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-NHC (S) OCH ₃ S (O) CH ₃
G-1 3,5-Cl ₂ 2-NHC (S) OCH ₃ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-NHC (S) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHC (S) OEt SCH ₃
G-1 3,5-Cl ₂ 2-NHC (S) SCH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-NHC (S) SCH ₃ S (O) CH ₃
G-1 3,5-Cl ₂ 2-NHC (S) SCH ₃ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-NHC (S) SCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHC (S) SEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHSO ₂ CH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-NHSO ₂ CH ₃ S (O) CH ₃
G-1 3,5-Cl ₂ 2-NHSO ₂ CH ₃ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-NHSO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-NHSO ₂ CF ₃ SCH ₃
G-1 3,5-Cl ₂ 2-NHSO ₂ CF ₃ S (O) CH ₃
G-1 3,5-Cl ₂ 2-NHSO ₂ CF ₃ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-NHSO ₂ CF ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) CHO SCH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) CHO S (O) CH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) CHO SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) CHO SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) CH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) Et SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) Pr-n SCH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) Pr-c SCH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) Bu-t SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) CF ₃ SCH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) OEt SCH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) SCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) SEt SCH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (S) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (S) OEt SCH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (S) SCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) C (S) SEt SCH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) SO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) SO ₂ CF ₃ SCH ₃
G-1 3,5-Cl ₂ 2-N (Et) CHO SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (Et) C (O) CH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-N (Et) C (O) Et SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (Et) C (O) Pr-n SCH ₃
G-1 3,5-Cl ₂ 2-N (Et) C (O) Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (Et) C (O) Pr-c SCH ₃
G-1 3,5-Cl ₂ 2-N (Et) C (O) Bu-t SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (Et) C (O) CF ₃ SCH ₃
G-1 3,5-Cl ₂ 2-N (Et) C (O) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (Et) C (O) OEt SCH ₃
G-1 3,5-Cl ₂ 2-N (Et) C (O) SCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (Et) C (O) SEt SCH ₃
G-1 3,5-Cl ₂ 2-N (Et) C (S) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (Et) C (S) OEt SCH ₃
G-1 3,5-Cl ₂ 2-N (Et) C (S) SCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (Et) C (S) SEt SCH ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) SO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N (CH ₃ ) SO ₂ CF ₃ SCH ₃
G-1 3,5-Cl ₂ 2-N = CHOCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-N = C (CH ₃ ) OCH ₃ SCH ₃
G-1 3,5-Cl ₂ 2-N = C (CH ₃ ) OCH ₃ S (O) CH ₃
G-1 3,5-Cl ₂ 2-N = C (CH ₃ ) OCH ₃ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-N = C (CH ₃ ) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2- (D3-1a) SCH ₃
G-1 3,5-Cl ₂ 2-C (O) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-C (O) NH ₂ SCH ₃
G-1 3,5-Cl ₂ 2- (M7-1a) SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-C (S) NH ₂ SCH ₃
G-1 3,5-Cl ₂ 2-C (S) NH ₂ S (O) CH ₃
G-1 3,5-Cl ₂ 2-C (S) NH ₂ SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-C (S) NH ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2- (M9-1a) SCH ₃
G-1 3,5-Cl ₂ 2-Ph SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2- (D7-1a) SCH ₃
G-1 3,5-Cl ₂ 2- (D11-1a) SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2- (D22-1a) SCH ₃
G-1 3,5-Cl ₂ 2- (D28-1a) SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2- (D28-1b) CH ₃ SCH ₃
G-1 3,5-Cl ₂ 2- (D29-1a) SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2- (D30-1a) H SCH ₃
G-1 3,5-Cl ₂ 2- (D30-1a) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2- (D31-1a) H SCH ₃
G-1 3,5-Cl ₂ 2- (D31-1a) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2,3-F ₂ SCH ₃
G-1 3,5-Cl ₂ 2,5-F ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2,6-F ₂ SCH ₃
G-1 3,5-Cl ₂ 2-F-6-Cl SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-F-6-Br SCH ₃
G-1 3,5-Cl ₂ 2-F-6-CF ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-F-6-NO ₂ SCH ₃
G-1 3,5-Cl ₂ 2-Cl-3-F SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2,3-Cl ₂ SCH ₃
G-1 3,5-Cl ₂ 2-Cl-5-F SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2,5-Cl ₂ SCH ₃
G-1 3,5-Cl ₂ 2,6-Cl ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-Br-3-F SCH ₃
G-1 3,5-Cl ₂ 2-Br-5-F SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₃ -3-F SCH ₃
G-1 3,5-Cl ₂ 2-CH ₃ -3-FS (O) CH ₃
G-1 3,5-Cl ₂ 2-CH ₃ -3-F SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-CH ₃ -3-F SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₃ -3-Cl SCH ₃
G-1 3,5-Cl ₂ 2,3- (CH ₃ ) ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₃ -5-F SCH ₃
G-1 3,5-Cl ₂ 2-CH ₃ -5-Cl SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2,5- (CH ₃ ) ₂ SCH ₃
G-1 3,5-Cl ₂ 2-CH ₃ -6-F SCH ₃
G-1 3,5-Cl ₂ 2-CH ₃ -6-FS (O) CH ₃
G-1 3,5-Cl ₂ 2-CH ₃ -6-F SO ₂ CH ₃
G-1 3,5-Cl ₂ 2-CH ₃ -6-F SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₃ -6-Cl SCH ₃
G-1 3,5-Cl ₂ 2,6- (CH ₃ ) ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CH ₃ -6-CF ₃ SCH ₃
G-1 3,5-Cl ₂ 2-CF ₃ -5-F SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CF ₃ -5-Cl SCH ₃
G-1 3,5-Cl ₂ 2-OCH ₃ -3-F SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-OCH ₃ -5-F SCH ₃
G-1 3,5-Cl ₂ 2-OCH ₃ -5-Cl SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ 2-CN-3-F SCH ₃
G-1 3-Cl-5-Br 2-Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-5-Br 2-OEt SCH ₃
G-1 3-Cl-5-Br 2-OPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-5-Br 2-OSO ₂ CH ₃ SCH ₃
G-1 3-Cl-5-Br 2-NHEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-5-Br 2-NHPr-i SCH ₃
G-1 3-Cl-5-Br 2-N (CH ₃ ) ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-5-Br 2-NHC (O) CH ₃ SCH ₃
G-1 3-Cl-5-Br 2-NHC (O) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Br ₂ 2-Pr-i SCH ₃
G-1 3,5-Br ₂ 2-OEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Br ₂ 2-OPr-i SCH ₃
G-1 3,5-Br ₂ 2-OSO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Br ₂ 2-NHEt SCH ₃
G-1 3,5-Br ₂ 2-NHPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Br ₂ 2-N (CH ₃ ) ₂ SCH ₃
G-1 3,5-Br ₂ 2-NHC (O) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Br ₂ 2-NHC (O) OCH ₃ SCH ₃
G-1 3-Cl-5-I 2-Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-5-I 2-OEt SCH ₃
G-1 3-Cl-5-I 2-OPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-5-I 2-OSO ₂ CH ₃ SCH ₃
G-1 3-Cl-5-I 2-NHEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-5-I 2-NHPr-i SCH ₃
G-1 3-Cl-5-I 2-N (CH ₃ ) ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-5-I 2-NHC (O) CH ₃ SCH ₃
G-1 3-Cl-5-I 2-NHC (O) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ -4-F 2-Pr-i SCH ₃
G-1 3-CF ₃ -4-F 2-OEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ -4-F 2-OPr-i SCH ₃
G-1 3-CF ₃ -4-F 2-OSO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ -4-F 2-NHEt SCH ₃
G-1 3-CF ₃ -4-F 2-NHPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ -4-F 2-N (CH ₃ ) ₂ SCH ₃
G-1 3-CF ₃ -4-F 2-NHC (O) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ -4-F 2-NHC (O) OCH ₃ SCH ₃
G-1 3-F-5-CF ₃ 2-Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-F-5-CF ₃ 2-OEt SCH ₃
G-1 3-F-5-CF ₃ 2-OPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-F-5-CF ₃ 2-OSO ₂ CH ₃ SCH ₃
G-1 3-F-5-CF ₃ 2-NHEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-F-5-CF ₃ 2-NHPr-i SCH ₃
G-1 3-F-5-CF ₃ 2-N (CH ₃ ) ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-F-5-CF ₃ 2-NHC (O) CH ₃ SCH ₃
G-1 3-F-5-CF ₃ 2-NHC (O) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ -4-Cl 2-Pr-i SCH ₃
G-1 3-CF ₃ -4-Cl 2-OEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ -4-Cl 2-OPr-i SCH ₃
G-1 3-CF ₃ -4-Cl 2-OSO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ -4-Cl 2-NHEt SCH ₃
G-1 3-CF ₃ -4-Cl 2-NHPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ -4-Cl 2-N (CH ₃ ) ₂ SCH ₃
G-1 3-CF ₃ -4-Cl 2-NHC (O) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-CF ₃ -4-Cl 2-NHC (O) OCH ₃ SCH ₃
G-1 3-Cl-5-CF ₃ 2-Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-5-CF ₃ 2-OEt SCH ₃
G-1 3-Cl-5-CF ₃ 2-OPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-5-CF ₃ 2-OSO ₂ CH ₃ SCH ₃
G-1 3-Cl-5-CF ₃ 2-NHEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-5-CF ₃ 2-NHPr-i SCH ₃
G-1 3-Cl-5-CF ₃ 2-N (CH ₃ ) ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-5-CF ₃ 2-NHC (O) CH ₃ SCH ₃
G-1 3-Cl-5-CF ₃ 2-NHC (O) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Br-5-CF ₃ 2-Pr-i SCH ₃
G-1 3-Br-5-CF ₃ 2-OEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Br-5-CF ₃ 2-OPr-i SCH ₃
G-1 3-Br-5-CF ₃ 2-OSO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Br-5-CF ₃ 2-NHEt SCH ₃
G-1 3-Br-5-CF ₃ 2-NHPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Br-5-CF ₃ 2-N (CH ₃ ) ₂ SCH ₃
G-1 3-Br-5-CF ₃ 2-NHC (O) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Br-5-CF ₃ 2-NHC (O) OCH ₃ SCH ₃
G-1 3,5- (CF ₃ ) ₂ 2-Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ 2-OEt SCH ₃
G-1 3,5- (CF ₃ ) ₂ 2-OPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ 2-OSO ₂ CH ₃ SCH ₃
G-1 3,5- (CF ₃ ) ₂ 2-NHEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ 2-NHPr-i SCH ₃
G-1 3,5- (CF ₃ ) ₂ 2-N (CH ₃ ) ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ 2-NHC (O) CH ₃ SCH ₃
G-1 3,5- (CF ₃ ) ₂ 2-NHC (O) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ -4-F 2-Pr-i SCH ₃
G-1 3,5-Cl ₂ -4-F 2-OEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ -4-F 2-OPr-i SCH ₃
G-1 3,5-Cl ₂ -4-F 2-OSO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ -4-F 2-NHEt SCH ₃
G-1 3,5-Cl ₂ -4-F 2-NHPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ -4-F 2-N (CH ₃ ) ₂ SCH ₃
G-1 3,5-Cl ₂ -4-F 2-NHC (O) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Cl ₂ -4-F 2-NHC (O) OCH ₃ SCH ₃
G-1 3,4,5-Cl ₃ 2-Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,4,5-Cl ₃ 2-OEt SCH ₃
G-1 3,4,5-Cl ₃ 2-OPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,4,5-Cl ₃ 2-OSO ₂ CH ₃ SCH ₃
G-1 3,4,5-Cl ₃ 2-NHEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,4,5-Cl ₃ 2-NHPr-i SCH ₃
G-1 3,4,5-Cl ₃ 2-N (CH ₃ ) ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,4,5-Cl ₃ 2-NHC (O) CH ₃ SCH ₃
G-1 3,4,5-Cl ₃ 2-NHC (O) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Br ₂ -4-F 2-Pr-i SCH ₃
G-1 3,5-Br ₂ -4-F 2-OEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Br ₂ -4-F 2-OPr-i SCH ₃
G-1 3,5-Br ₂ -4-F 2-OSO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Br ₂ -4-F 2-NHEt SCH ₃
G-1 3,5-Br ₂ -4-F 2-NHPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Br ₂ -4-F 2-N (CH ₃ ) ₂ SCH ₃
G-1 3,5-Br ₂ -4-F 2-NHC (O) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5-Br ₂ -4-F 2-NHC (O) OCH ₃ SCH ₃
G-1 3,4-F ₂ -5-CF ₃ 2-Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,4-F ₂ -5-CF ₃ 2-OEt SCH ₃
G-1 3,4-F ₂ -5-CF ₃ 2-OPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,4-F ₂ -5-CF ₃ 2-OSO ₂ CH ₃ SCH ₃
G-1 3,4-F ₂ -5-CF ₃ 2-NHEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,4-F ₂ -5-CF ₃ 2-NHPr-i SCH ₃
G-1 3,4-F ₂ -5-CF ₃ 2-N (CH ₃ ) ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,4-F ₂ -5-CF ₃ 2-NHC (O) CH ₃ SCH ₃
G-1 3,4-F ₂ -5-CF ₃ 2-NHC (O) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-4-F-5-CF ₃ 2-Pr-i SCH ₃
G-1 3-Cl-4-F-5-CF ₃ 2-OEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-4-F-5-CF ₃ 2-OPr-i SCH ₃
G-1 3-Cl-4-F-5-CF ₃ 2-OSO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-4-F-5-CF ₃ 2-NHEt SCH ₃
G-1 3-Cl-4-F-5-CF ₃ 2-NHPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-4-F-5-CF ₃ 2-N (CH ₃ ) ₂ SCH ₃
G-1 3-Cl-4-F-5-CF ₃ 2-NHC (O) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3-Cl-4-F-5-CF ₃ 2-NHC (O) OCH ₃ SCH ₃
G-1 3,4-Cl ₂ -5-CF ₃ 2-Pr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,4-Cl ₂ -5-CF ₃ 2-OEt SCH ₃
G-1 3,4-Cl ₂ -5-CF ₃ 2-OPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,4-Cl ₂ -5-CF ₃ 2-OSO ₂ CH ₃ SCH ₃
G-1 3,4-Cl ₂ -5-CF ₃ 2-NHEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,4-Cl ₂ -5-CF ₃ 2-NHPr-i SCH ₃
G-1 3,4-Cl ₂ -5-CF ₃ 2-N (CH ₃ ) ₂ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,4-Cl ₂ -5-CF ₃ 2-NHC (O) CH ₃ SCH ₃
G-1 3,4-Cl ₂ -5-CF ₃ 2-NHC (O) OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ -4-Cl 2-Pr-i SCH ₃
G-1 3,5- (CF ₃ ) ₂ -4-Cl 2-OEt SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ -4-Cl 2-OPr-i SCH ₃
G-1 3,5- (CF ₃ ) ₂ -4-Cl 2-OSO ₂ CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ -4-Cl 2-NHEt SCH ₃
G-1 3,5- (CF ₃ ) ₂ -4-Cl 2-NHPr-i SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ -4-Cl 2-N (CH ₃ ) ₂ SCH ₃
G-1 3,5- (CF ₃ ) ₂ -4-Cl 2-NHC (O) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-1 3,5- (CF ₃ ) ₂ -4-Cl 2-NHC (O) OCH ₃ SCH ₃
G-3 5-Cl − SCH ₂ C (O) NHCH ₂ CF ₃
G-3 5-CF ₃ − SCH ₃
G-3 5-CF ₃ − S (O) CH ₃
G-3 5-CF ₃ -SO ₂ CH ₃
G-3 5-CF ₃ − SCH ₂ C (O) NHCH ₂ CF ₃
G-3 5-CF ₃ -6-Cl-SCH ₃
G-3 5-NO ₂ -6-Cl-SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2-Cl − SCH ₃
G-4 2-Br − SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2-CF ₃ − SCH ₃
G-4 2-CF ₃ − S (O) CH ₃
G-4 2-CF ₃ -SO ₂ CH ₃
G-4 2-CF ₃ − SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-F ₂ − SCH ₃
G-4 2,6-Cl ₂ − SCH ₃
G-4 2,6-Cl ₂ − S (O) CH ₃
G-4 2,6-Cl ₂ -SO ₂ CH ₃
G-4 2,6-Cl ₂ − SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-Cl ₂ 2-F SCH ₃
G-4 2,6-Cl ₂ 2-FS (O) CH ₃
G-4 2,6-Cl ₂ 2-F SO ₂ CH ₃
G-4 2,6-Cl ₂ 2-F SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-Cl ₂ 2-Cl SCH ₃
G-4 2,6-Cl ₂ 2-Cl S (O) CH ₃
G-4 2,6-Cl ₂ 2-Cl SO ₂ CH ₃
G-4 2,6-Cl ₂ 2-Cl SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-Cl ₂ 2-Br SCH ₃
G-4 2,6-Cl ₂ 2-Br S (O) CH ₃
G-4 2,6-Cl ₂ 2-Br SO ₂ CH ₃
G-4 2,6-Cl ₂ 2-Br SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-Cl ₂ 2-I SCH ₃
G-4 2,6-Cl ₂ 2-IS (O) CH ₃
G-4 2,6-Cl ₂ 2-I SO ₂ CH ₃
G-4 2,6-Cl ₂ 2-I SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-Cl ₂ 2-CH ₃ SCH ₃
G-4 2,6-Cl ₂ 2-CH ₃ S (O) CH ₃
G-4 2,6-Cl ₂ 2-CH ₃ SO ₂ CH ₃
G-4 2,6-Cl ₂ 2-CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-Cl ₂ 2-Et SCH ₃
G-4 2,6-Cl ₂ 2-Et S (O) CH ₃
G-4 2,6-Cl ₂ 2-Et SO ₂ CH ₃
G-4 2,6-Cl ₂ 2-Et SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-Cl ₂ 2-CF ₃ SCH ₃
G-4 2,6-Cl ₂ 2-CF ₃ S (O) CH ₃
G-4 2,6-Cl ₂ 2-CF ₃ SO ₂ CH ₃
G-4 2,6-Cl ₂ 2-CF ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-Cl ₂ 2-OCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-Cl ₂ 2-OCHF ₂ SCH ₃
G-4 2,6-Cl ₂ 2-OCF ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-Cl ₂ 2-SCH ₃ SCH ₃
G-4 2,6-Cl ₂ 2-SCF ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-Cl ₂ 2-NO ₂ SCH ₃
G-4 2,6-Cl ₂ 2-NHCH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-Cl ₂ 2-NHEt SCH ₃
G-4 2,6-Cl ₂ 2-NHC (O) CH ₃ SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6-Br ₂ − SCH ₃
G-4 2,6-Br ₂ − S (O) CH ₃
G-4 2,6-Br ₂ -SO ₂ CH ₃
G-4 2,6-Br ₂ -SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2-Br-6-CF ₃ − SCH ₃
G-4 2-Br-6-CF ₃ − S (O) CH ₃
G-4 2-Br-6-CF ₃ -SO ₂ CH ₃
G-4 2-Br-6-CF ₃ − SCH ₂ C (O) NHCH ₂ CF ₃
G-4 2,6- (CF ₃ ) ₂ − SCH ₃
G-4 2,6- (CF ₃ ) ₂ − S (O) CH ₃
G-4 2,6- (CF ₃ ) ₂ − SO ₂ CH ₃
G-4 2,6- (CF ₃ ) ₂ − SCH ₂ C (O) NHCH ₂ CF ₃
G-13 4-CF ₃ − SCH ₃
G-13 4-CF ₃ − S (O) CH ₃
G-13 4-CF ₃ − SO ₂ CH ₃
G-13 4-CF ₃ − SCH ₂ C (O) NHCH ₂ CF ₃
G-13 5-CF ₃ − SCH ₃
G-13 5-CF ₃ − S (O) CH ₃
G-13 5-CF ₃ -SO ₂ CH ₃
G-13 5-CF ₃ − SCH ₂ C (O) NHCH ₂ CF ₃
G-13 4,5-Cl ₂ − SCH ₃
G-13 4,5-Cl ₂ − S (O) CH ₃
G-13 4,5-Cl ₂ -SO ₂ CH ₃
G-13 4,5-Cl ₂ -SCH ₂ C (O) NHCH ₂ CF ₃
G-13 4-Cl-5-Br − SCH ₃
G-13 4-Cl-5-Br − S (O) CH ₃
G-13 4-Cl-5-Br − SO ₂ CH ₃
G-13 4-Cl-5-Br − SCH ₂ C (O) NHCH ₂ CF ₃
G-13 4-Br-5-Cl − SCH ₃
G-13 4-Br-5-Cl-S (O) CH ₃
G-13 4-Br-5-Cl-SO ₂ CH ₃
G-13 4-Br-5-Cl-SCH ₂ C (O) NHCH ₂ CF ₃
G-13 4,5-Br ₂ − SCH ₃
G-13 4,5-Br ₂ − S (O) CH ₃
G-13 4,5-Br ₂ − SO ₂ CH ₃
G-13 4,5-Br ₂ -SCH ₂ C (O) NHCH ₂ CF ₃
G-14 5-CF ₃ − SCH ₃
G-14 5-CF ₃ − S (O) CH ₃
G-14 5-CF ₃ -SO ₂ CH ₃
G-14 5-CF ₃ − SCH ₂ C (O) NHCH ₂ CF ₃
G-17a 5-CF ₃ − SCH ₃
G-17a 5-CF ₃ − S (O) CH ₃
G-17a 5-CF ₃ − SO ₂ CH ₃
G-17a 5-CF ₃ − SCH ₂ C (O) NHCH ₂ CF ₃
G-20 4-CF ₃ − SCH ₃
G-20 4-CF ₃ − S (O) CH ₃
G-20 4-CF ₃ − SO ₂ CH ₃
G-20 4-CF ₃ − SCH ₂ C (O) NHCH ₂ CF ₃
G-20 5-CF ₃ − SCH ₃
G-20 5-CF ₃ − S (O) CH ₃
G-20 5-CF ₃ -SO ₂ CH ₃
G-20 5-CF ₃ − SCH ₂ C (O) NHCH ₂ CF ₃
G-21 2-CF ₃ − SCH ₃
G-21 2-CF ₃ − S (O) CH ₃
G-21 2-CF ₃ -SO ₂ CH ₃
G-21 2-CF ₃ − SCH ₂ C (O) NHCH ₂ CF ₃
G-22 2-Cl − SCH ₃
G-22 2-Cl − S (O) CH ₃
G-22 2-Cl − SO ₂ CH ₃
G-22 2-Cl − SCH ₂ C (O) NHCH ₂ CF ₃
―――――――――――――――――――――――――――――――――――――――
Table 4

―――――――――― ―――――――――― ――――――――――
LQ LQ LQ
―――――――――― ―――――――――― ――――――――――
CH ₃ CF ₂ Br CH ₂ C (O) NHPr-i
Et CH ₂ CF ₃ CH ₂ C (O) NHCH ₂ Pr-i
CH ₂ F CH ₂ CN CH ₂ C (O) NHCH ₂ CH ₂ F
CHF ₂ CH ₂ C (O) NH ₂ CH ₂ C (O) NHCH ₂ CH ₂ Cl
CF ₃ CH ₂ C (O) NHCH ₃ CH ₂ C (O) NHCH ₂ CF ₃
CF ₂ Cl CH ₂ C (O) NHEt CH ₂ C (O) N (CH ₃ ) ₂
―――――――――― ―――――――――― ――――――――――
The compounds of the present invention are stored in warehouses, so-called agricultural pests that harm agricultural and horticultural crops and trees, so-called livestock pests that parasitize livestock and poultry, so-called sanitary pests that cause various adverse effects in the human living environment such as houses. It is possible to effectively control insects such as so-called stored grain pests that harm cereals and the like, and pests such as mites, crustaceans, molluscs, and nematodes that occur and harm in similar situations at low concentrations.

Specific examples of insects, mites, crustaceans, molluscs and nematodes that can be controlled using the compounds of the present invention include:
Adoxophyes honmai, Adoxophyes orana faciata, Archips breviplicanus, Archips fuscocupreanus, Grapholita molesta, Chama magnan Leguminivora glycinivorella), Matsumuraeses phaseoli, Pandemis heparana, Bucculatrix pyrivorella, Lyonetia clerkella, Lyonetia prunifal ringoniella), mandarin leaf moth (Phyllocnistis citrella), green moth (Acrolepiopsis sapporensis), wild moth (Acrolepiopsis suzukiella), black moth (Plutella xylostella), oyster leaf moth (Stathmopoda masinissa), cystogram tria ora gossypiella), peach sinker moth (Carposina sasakii), codling moth (Cydla pomonella), green moth (Chilo suppressalis), corn borer (Cnaphalocrocis medinalis), peach moth (Conogethes punctiferalis), cotton moth (Dia) (Etiella zinckenella), Glyphodes pyloalis, Hellula undalis, Ostrinia furnacalis, Ostrinia scapulalis, European corn borer (Ostrinia nubilaliseter, Pesta pal) ), White-tailed butterfly (Pieris brassicae), white-tailed butterfly (Pieris rapae crucivora), mugwort (Ascotis selenaria), soy bean looper (Pseudoplusia includens), chadokuga (Euproctis pseudoconspersa), maimaiga (Lymantria disparia), thymeina ), White-spotted starfish (Hyphantria cunea), white-spotted starfish (Lemyra imparilis), Akebiko-no-ha (Adris tyrannus), red-footed butterfly (Aedia leucomelas), red-footed squirrel (Agrotis ipsilon), red-tailed squirrel (Agrotis segetum) Uwaba (Ctenoplusia agnata), Helicoverpa armigera, Tobacco moth (Helicoverpa assulta), Cotton ball worm (Helicoverpa zea), Tobacco bad worm (Heliothis virescens), Mamestra brassicae, Mythimna naa ), Southern army worm (Spodoptera eridania), Spodoptera exigua, Fall army worm (Spodoptera frugiperda), Cotton leaf worm (Spodoptera littoralis), Spodoptera litura, Spodoptera litura, Spodoptera era ), Leeb Berry Moss (Endopiza viteana), tomato horn worm (Manduca quinquemaculata), tobacco horn worm (Manduca sexta) lepidopteran insects such as,
Thrips thrips (Frankliniella intonsa), Citrus thrips (Frankliniella occidentalis), Croton thrips (Prithia thrips) The total insect of the
Spotted beetle (Dolycoris baccarum), sea turtle (Eurydema rugosum), bark beetle (Eysarcoris aeneus), horseshoe beetle (Eysarcoris lewisi), white-headed beetle (Eysarcoris ventralis), subtilus , Nezara antennata, Nezara viridula, Piezodorus hybneri, Plautia crossota, Scotinophora lurida, tiger C Stink bug (Leptocorisa chinensis), Hoso-heli beetle (Riptortus clavatus), Red-headed beetle (Rhopalus msculatus), Cavelerius saccharivorus, Toba hemipterus cus, Togo hemipterus (Stephanitis pyrioides), Kuroto Bikasumi turtle (Halticus insularis), Turned plant bug (Lygus lineolaris), Nagamu sika turtle (Stenodema sibiricum), Akasika sika turtle (Stenotus rubrovittatus), Rice moss turtle (Trigonotylus caelestialium), ical Arisbori dia Green leafhopper (Balclutha saltuella), butterfly leafhopper (Epiacanthus stramineus), potato leaf hopper (Empoasca fabae), oyster leafhopper (Empoasca nipponica), Chanomidorimempei (Empoasca onukii), omenosaka ), Leafhopper leafhopper (Macrosteles striifrons), leafhopper leafhopper (Nephotettix cinctinceps), cotton-free hopper (Psuedatomoscelis seriatus), leafhopper (Laodelphax striatella), leafhopper (Nilaparvata lugens) Psylla pyrisuga, Aleurocanthus spiniferus, Silver leaf whitefly (Bemisia argentifolii), Tobacco whitefly (Bemisia tabaci), Citrus whitefly (Dialeurodes citri), Onsitsuna whitefly (trialeurous grape rum, Trialeurodes vapor Cotton Aphid (Aphis gossypii), Snowy Aphid (Aphis spiraecola), Peach Aphid (Myzus persicae), Komikan Aphid (Toxoptera aurantii), Alaska Scale Aphid (Drosicha corpulenta), Iceria scale P solani), citrus scale insect (Planococcus citri), stag beetle scale (Planococcus kuraunhiae), stag beetle scale (Pseudococcus comstocki), horn beetle (Ceroplastes ceriferus), ruby rotum (Ceroplastes rubens), red scallop Nymphalidae (Comstockaspis perniciosa), tea scale (Fiorinia theae), chanomarine scale insect (Pseudaonidia paeoniae), stag beetle (Pseudaulacaspis pentagona), scallop scale (Pseudaulacaspis prunicola), euglena (Unaspis yanonensis), Hemiptera insects such as Cimex lectularius,
Douganebubui (Anomala cuprea), Japanese common squirrel (Anomala rufocuprea), Core ohanamuri (Gametis jucunda), Nagachakogane (Heptophylla picea), Japanese beetle (Popillia japonica), Colorado potato beetle (Lepinotarsa decemlineata) White-footed beetle (Melanotus tamsuyensis), Tobacco beetle (Lasioderma serricorne), Himetaketakekisui (Epuraea domina), Green beetle (Epilachna varivestis), Nijuya-hoshi-tento (Epilachna vigintioctopunctata), T. Tribolium castaneum, Anoplophora malasiaca, Monochamus alternatus, Psacothea hilaris, Xylotrechus pyrrhoderus, callosobruchus, Callosobruchus Western Root beetle (Chaetocnema concinna), Southern corn root worm (Diabrotica undecimpunctata), Western corn root worm (Diabrotica virgifera), Northern corn root worm (Diabrotica barberi), Inedro beetle (Oulema oryzae), Phyllotreta nastriatum, Phyllotreta striol Tobet beetle (Psylliodes angusticollis), peach weevil (Rhynchites heros), aphid weevil (Cylas formicarius), cotton weevil (Anthonomus grandis), weevil (Echinocnemus squameus), weevil (Euscepes postfasciatus) Rice weevil (Lissohoptrus oryzophilus), horned weevil (Otiorhynchus sulcatus), granary weevil (Sitophilus granarius), hornet weevil (Sitophilus zeamais), bark weevil (Sphenophorus venatus vestitus moth) erus fuscipes), etc.
Soybean flies (Asphondylia yushimai), mud wings (Sitodiplosis mosellana), fruit flies (Bactrocera cucurbitae), citrus fruit flies (Bactrocera dorsalis), citrus fruit flies (Ceratitis capitata), rice moth flies Leafhopper (Agromyza oryzae), Leafworm (Chromatomyia horticola), Eggplant leaffly (Liriomyza bryoniae), Leafhopper (Liriomyza chinensis), Tomato leaffly (Liriomyza sativae), Beanworm (Liriomyza trifoli), Liriomyza trifoli (Pegomya cunicularia), apple haggot (Rhagoletis pomonella), hessian fly (Mayetiola destructor), housefly (Musca domestica), barn fly (Stomoxys calcitrans), sheep flies (Melophagus ovinus), bullflies (Hypoderma bovisma), , Sheep flies (Oestrus ovis), tsetse flies (Glossina palpalis, Glossina morsitans), black-headed ayu (Prosimulium yezoensis), bullfly (Tabanus trigonus), giant fly (Telmatoscopus albipunctatus), nipponen sip (Leptocons) Diptera, such as Aedes aegypti), Aedes albopicutus, Anopheles hyracanus sinesis,
Bumblebee (Apethymus kuri), Bumblebee (Athalia rosae), Bumblebee (Arge pagana), Bumblebee (Neodiprion sertifer), Bumblebee (Dryocosmus kuriphilus), Gantai (Eciton burchelli, Eciton schmitus), Eciton burchelli, Eciton schmitus mandarina), bulldog ant (Myrmecia spp.), fire ant (Solenopsis spp.), pharaoh ant (Monomorium pharaonis), etc.
Straight-legged insects, such as Telemacrylus emma, Kera (Gryllotalpa orientalis), Tosama grasshopper (Locusta migratoria), Oxya yezoensis, Sabaquat grasshopper (Schistocerca gregaria),
Coleoptera insects such as the white-headed beetle (Onychiurus folsomi), the Siberian white-headed beetle (Onychiurus sibiricus), the Bourletiella hortensis,
Reticulate insects such as black cockroach (Periplaneta fuliginosa), cockroach (Periplaneta japonica), German cockroach (Blattella germanica),
Termite insects such as the termites (Coptotermes formosanus), Yamato termites (Reticulitermes speratus), Taiwan termites (Odontotermes formosanus),
Insect insects such as cat fleas (Ctenocephalidae felis), dog fleas (Ctenocephalides canis), chicken fleas (Echidnophaga gallinacea), human fleas (Pulex irritans), keops rat fleas (Xenopsylla cheopis),
Insects such as chicken lice (Menacanthus stramineus) and bovine lice (Bovicola bovis),
Lice insects such as cattle lice (Haematopinus eurysternus), pig lice (Haematopinus suis), cattle white lice (Linognathus vituli), horned lice (Solenopotes capillatus),
Dust mites such as cyclamen dust mite (Phytonemus pallidus), chano mite mite (Polyphagotarsonemus latus), and mites (Tarsonemus bilobatus),
Spider mites (Penthaleus erythrocephalus), wheat mites (Penthaleus major), etc.
Spider mites such as rice spider mite (Oligonychus shinkajii), citrus spider mite (Panonychus citri), blue spider mite (Panonychus mori), apple spider mite (Panonychus ulmi), Kanzawa spider mite (Tetranychus kanzawai), spider mite (Tetranychus urticae), etc.
Chinese cabbage mite (Acaphylla theavagrans), tulip rust mite (Aceria tulipae), tomato rust mite (Aculops lycopersici), citrus red mite (Aculops pelekassi), apple rust mite (Aculus schlechtendali), black rust mite (Eriophyes chitrastrostrum) ), Etc.,
Acarids such as robin mite (Rhizoglyphus robini), mushroom mite (Tyrophagus putrescentiae), spinach mushroom mite (Tyrophagus similis),
Bee mites such as honeybee mite (Varroa jacobsoni),
Tick tick (Boophilus microplus), Rhipicephalus sanguineus, Tick tick (Haemaphysalis longicornis), Tick tick (Haemophysalis flava), Tick tick (Haemophysalis campanulata), Tick tick (Ixo tus tick) Amblyomma spp.), Ticks such as Dermacentor spp.
Claw mites (Cheyletiella yasguri), claw mites (Cheyletiella blakei),
Acne mites, such as Inodecarid mites (Demodex canis), Caterpillar mites (Demodex cati),
Cucumber mites such as sheep cucumber mites (Psoroptes ovis),
Spider mites, such as Sarcoptes scabiei, Caterpillar spider mite (Notoedres cati), Chicken spider mite (Knemidocoptes spp.),
Crustaceans such as the armadillum (Armadillidium vulgare),
Gastropods such as Pomacea canaliculata, African mussel (Achatina fulica), Slug (Meghimatium bilineatum), Chaukoura slug (Limax Valentiana), Uskawamai (Acusta despecta sieboldiana), Mishamai mai (Euhadra peliomphala), etc.
Southern nematode nematode (Prathylenchus coffeae), Kitane-negususa nematode (Prathylenchus penetrans), Kurume rushes nematode (Prathylenchus vulnus), potato cyst nematode (Globodera rostochiensis), soybean cyst nematode (Heterodera lypter Nematodes such as root-knot nematode (Meloidogyne incognita), rice-spotted nematode (Aphelenchoides besseyi), pine wood nematode (Bursaphelenchus xylophilus),
However, the present invention is not limited to these examples.

In addition, specific examples of endoparasites such as livestock, poultry, and pet animals that can be controlled using the present compound include
Haemonchus, Trichostrongylus, Ostertagia, Nematodirus, Cooperia, Ascaris, Bunostomum, Esphagotome Genus (Oesophagostomum), Chabertia, Trichuris, Storongylus, Trichonema, Dictyocaulus, Capillaria, Heterakis ), Toxocara, Ascaridia, Oxyuris, Ancylostoma, Uncinaria, Toxacaris, Parascaris and other nematodes ,
Filariidae nematodes such as Wuchereria, Blueia, Onchoceca, Dirofilaria, Loa
Dracunculidae nematodes such as the genus Deacunculus,
Dogworms (Dipylidium caninum), caterpillars (Taenia taeniaeformis), rodents (Taenia solium), striped tapeworms (Taenia saginata), contracted tapeworms (Hymenolepis diminuta), Benedenta (Moniezia benedeni), Tapeworms such as Diphyllobothrium latum, Manson cleftworm (Diphyllobothrium erinacei), Echinococcus granulosus, Echinococcus multilocularis,
Fasciola hepatica (F. gigantica), Westermann lung fluke (Paragonimus westermanii), hypertrophic fluke (Fasciolopsic bruski), pancreatic fluke (Eurytrema pancreaticum, E. coelomaticum), liver fluke (Clonorchis sinensis), Schistosoma Schistosoma japonicum), Schistosoma haematobium, Schistosoma mansoni, etc.,
Eimeria tenella, Eimeria acervulina, Eimeria brunetti, Eimeria maxima, Eimeria necatrix, Eimeria bovis, Eimeria bovis Eimeria spp., Such as Eimeria ovinoidalis,
Trypanosomsa cruzi, Leishmania spp., Plasmodium spp., Babesis spp., Trichomonadidae spp., Histomanas spp., Giardia (Giardia spp.), Toxoplasma spp., Entamoeba histolytica, Theileria spp.,
However, the present invention is not limited to these examples.

  Furthermore, the compound of the present invention is also effective against pests that have developed resistance to existing insecticides such as organophosphorus compounds, carbamate compounds, and pyrethroid compounds.

  That is, the compound of the present invention is composed of the order of mucous eyes (Coleoptera), reticulates (Roaches), straight moths (Grasshoppers), termites, common moths (Thrips), hemimorphs (stink bugs and leafhoppers). Eyes), Lepidoptera (Lepidoptera), Coleoptera (Coleoptera), Hymenoptera (Hymenoptera), Diptera (Flyidae), Islamic (Flea), Liceid, and other insects, ticks In addition, pests belonging to gastropods and nematodes can be effectively controlled at low concentrations. On the other hand, the compounds of the present invention are extremely useful with little adverse effect on mammals, fish, crustaceans and beneficial insects (beneficial insects such as bees and bumblebees, natural enemies such as honeybees, wasps, mistletoe flies, mosquitoes, and mites). Has features.

  When using the compound of the present invention, it is usually mixed with a suitable solid carrier or liquid carrier, and if desired, a surfactant, penetrant, spreading agent, thickener, antifreezing agent, binder, anti-caking agent. , Disintegrating agents, antifoaming agents, preservatives and anti-degradation agents, etc., and soluble concentrate, emulsion (emulsifiable concentrate), wettable powder, water-soluble powder, granular water Water dispersible granule, water soluble granule, suspension concentrate, concentrated emulsion, suspoemulsion, microemulsion, dustable powder ), Granule tablets, and emulsifiable gels, and can be put to practical use. Further, from the viewpoint of labor saving and safety improvement, the preparations of any of the above dosage forms can be provided by being enclosed in a water-soluble package such as a water-soluble capsule and a bag of a water-soluble film.

  Examples of the solid carrier include quartz, calcite, gypsum, dolomite, chalk, kaolinite, pyrophyllite, sericite, halosite, metahalosite, kibushi clay, glazed clay, porcelain stone, siegrite, and allophane. Natural minerals such as shirasu, kira, talc, bentonite, activated clay, acid clay, pumice, attapulgite, zeolite and diatomaceous earth, for example, calcined clay, perlite, shirasu balloon, vermiculite, attapulgus clay and calcined diatomaceous earth Baked products such as magnesium carbonate, calcium carbonate, sodium carbonate, sodium bicarbonate, ammonium sulfate, sodium sulfate, magnesium sulfate, diammonium hydrogen phosphate, ammonium dihydrogen phosphate and potassium chloride, such as glucose, fructose , And Sugars such as sugar and lactose, polysaccharides such as starch, powdered cellulose and dextrin, organic materials such as urea, urea derivatives, benzoic acid and benzoic acid salts, such as wood flour, cork flour, corn cobs, walnut shells and Examples include plants such as tobacco stalks, fly ash, white carbon (for example, hydrous synthetic silica, anhydrous synthetic silica, hydrous synthetic silicate, etc.) and fertilizers.

Examples of the liquid carrier include xylene, alkyl (C ₉ or C ₁₀ etc.) benzene, phenyl xylyl ethane and alkyl (C ₁ or C ₃ etc.) naphthalene and other aromatic hydrocarbons, machine oil, normal paraffin, isoparaffin and Aliphatic hydrocarbons such as naphthene, mixtures of aromatic and aliphatic hydrocarbons such as kerosene, alcohols such as ethanol, isopropanol, cyclohexanol, phenoxyethanol and benzyl alcohol, ethylene glycol, propylene glycol, diethylene glycol, hexylene glycol , Polyhydric alcohols such as polyethylene glycol and polypropylene glycol, propyl cellosolve, butyl cellosolve, phenyl cellosolve, propylene glycol monomethyl ether, propylene Ethers such as recall monoethyl ether, propylene glycol monopropyl ether, propylene glycol monobutyl ether and propylene glycol monophenyl ether, ketones such as acetophenone, cyclohexanone and γ-butyrolactone, fatty acid methyl esters, dialkyl esters of succinic acid, dialkyl esters of glutamic acid, adipine esters such as dialkyl ester and dialkyl phthalate esters, N- alkyl (C _1, C ₈ or C _12, etc.) acid amide pyrrolidone, soybean oil, linseed oil, rapeseed oil, coconut oil, such as cottonseed oil and castor oil Examples include fats and oils, dimethyl sulfoxide and water.

  These solid and liquid carriers may be used alone or in combination of two or more.

  Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkyl (mono or di) phenyl ether, polyoxyethylene (mono, di or tri) styryl phenyl ether, polyoxyethylene polyoxypropylene block copolymer, polyoxyethylene Ethylene fatty acid (mono or di) ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, castor oil ethylene oxide adduct, acetylene glycol, acetylene alcohol, ethylene oxide adduct of acetylene glycol, ethylene oxide adduct of acetylene alcohol and alkyl Nonionic surfactants such as glycosides, alkyl sulfate esters, alkylbenzene sulfonates, lignin sulfonates, Killsulfosuccinate, naphthalenesulfonate, alkylnaphthalenesulfonate, salt of formalin condensate of naphthalenesulfonic acid, salt of formalin condensate of alkylnaphthalenesulfonic acid, polyoxyethylene alkyl ether sulfate or phosphate ester salt, polyoxy Ethylene (mono or di) alkyl phenyl ether sulfate or phosphate ester salt, polyoxyethylene (mono, di or tri) styryl phenyl ether sulfate or phosphate ester salt, polycarboxylate (eg polyacrylate, polymaleate and Copolymers of maleic acid and olefins, etc.) and anionic surfactants such as polystyrene sulfonates, cationic surfactants such as alkylamine salts and alkyl quaternary ammonium salts, amino acid types and beties Amphoteric surfactants such as mold, and silicone-based surfactants and fluorinated surfactants.

  The content of these surfactants is not particularly limited, but is usually preferably in the range of 0.05 to 20 parts by weight per 100 parts by weight of the preparation of the present invention. These surfactants may be used alone or in combination of two or more.

  The application amount of the compound of the present invention varies depending on the application scene, application time, application method, cultivated crops, etc., but generally 0.005 to 50 kg per hectare (ha) is appropriate as the amount of active ingredient.

  On the other hand, when using the compound of the present invention for the control of the ectoparasites of mammals and birds as domestic animals and pets, an effective amount of the compound of the present invention is administered orally together with injection additives (intramuscular, Parenteral administration such as subcutaneous, intravenous, intraperitoneal; transdermal administration such as immersion, spraying, bathing, washing, pouring-on and spotting-on and dusting; nasal administration Can be administered. The compounds of the present invention can also be administered by molded products using strips, plates, bands, collars, ear marks, limb bands, labeling devices and the like. In administration, the compound of the present invention can be in any dosage form suitable for the administration route.

  Arbitrary forms to be prepared include solid preparations such as powders, granules, wettable powders, pellets, tablets, large pills, capsules, molded products containing active compounds; injection solutions, oral solutions, skin Liquid preparations used above or in body cavities; solution preparations such as pour-on, spot-on, flowable, and emulsion; semi-solid preparations such as ointments and gels.

  The solid preparation can be used mainly for oral administration or diluted with water for transdermal administration or environmental treatment. Solid preparations can be prepared by adding the active compound, if necessary, with adjuncts, mixing with appropriate excipients, and converting to the desired shape. Suitable excipients include, for example, inorganic substances such as carbonates, bicarbonates, phosphates, aluminum oxides, silicas, clays, and organic substances such as sugars, cellulose, crushed grains, and starches.

  Injection solutions can be administered intravenously, intramuscularly and subcutaneously. Injection solutions dissolve the active compound in a suitable solvent and, if necessary, solubilizers, acids, bases, buffer salts, antioxidants. And can be prepared by adding additives such as protective agents. Suitable solvents include water, ethanol, butanol, benzyl alcohol, glycerin, propylene glycol, polyethylene glycol, N-methylpyrrolidone and mixtures thereof, physiologically acceptable vegetable oils, synthetic oils suitable for injection, and the like. Examples of solubilizers include polyvinylpyrrolidone, polyoxyethylated castor oil, and polyoxyethylated sorbitan ester. Protecting agents include benzyl alcohol, trichlorobutanol, p-hydroxybenzoic acid ester and n-butanol.

  Oral solutions can be administered directly or diluted. It can be prepared in the same manner as an injectable solution.

  Flowables, emulsions, etc. can be administered directly or diluted transdermally or by environmental treatment.

  Solutions for use on the skin can be administered by dripping, spreading, rubbing, spraying, spraying or applying by dipping (dipping, bathing or washing). These solutions can be prepared in the same manner as injection solutions.

  Pour-on and spot-on agents can be dripped or sprayed onto a limited area of the skin, so that the active compound can be immersed in the skin and act systemically . Drops and drop preparations can be prepared by dissolving, suspending or emulsifying the active ingredient in suitable skin-compatible solvents or solvent mixtures. If necessary, auxiliary agents such as surfactants, colorants, absorption promoting substances, antioxidants, light stabilizers and adhesives may be added.

  Suitable solvents include water, alkanol, glycol, polyethylene glycol, polypropylene glycol, glycerin, benzyl alcohol, phenylethanol, phenoxyethanol, ethyl acetate, butyl acetate, benzyl benzoate, dipropylene glycol monomethyl ether, diethylene glycol monobutyl ether, acetone, Methyl ethyl ketone, aromatic and / or aliphatic hydrocarbons, vegetable or synthetic oil, DMF, liquid paraffin, light liquid paraffin, silicone, dimethylacetamide, N-methylpyrrolidone or 2,2-dimethyl-4-oxy-methylene-1, 3-dioxolane is mentioned. Absorption enhancers include DMSO, isopropyl myristate, dipropylene glycol pelargonate, silicone oil, aliphatic esters, triglycerides and fatty alcohols. Antioxidants include sulfites, metabisulfites, ascorbic acid, butylhydroxytoluene, butylhydroxyanisole and tocopherol.

  The emulsion can be administered orally, transdermally or as an injection. In emulsions, the active ingredient is dissolved in a hydrophobic phase or a hydrophilic phase, and this is added with a suitable emulsifier, and if necessary, a colorant, an absorption promoting substance, a protective agent, an antioxidant, a light-shielding agent, a thickening substance, etc. Can be prepared by homogenizing with other phase solvents together with other auxiliary agents.

  As hydrophobic phase (oil), paraffin oil, silicone oil, sesame oil, almond oil, castor oil, synthetic triglyceride, ethyl stearate, di-n-butyryl adipate, hexyl laurate, dipropylene glycol pelargonate, branched chain Of a short fatty acid having a chain length and a saturated fatty acid having a chain length of C16 to C18, isopropyl myristate, isopropyl palmitate, capryl / caprate of a saturated fatty alcohol having a chain length of C12 to C18, isopropyl stearate, oleyl oleate Decyl oleate, ethyl oleate, ethyl lactate, waxy fatty acid ester, dibutyl phthalate, diisopropyl adipate, isotridecyl alcohol, 2-octyldodecanol, cetyl stearyl alcohol, oleyl alcohol It is.

  Examples of the hydrophilic phase include water, propylene glycol, glycerin, and sorbitol.

  Emulsifiers include nonionic interfaces such as polyoxyethylated castor oil, polyoxyethylated sorbitan monoolefin acid, sorbitan monostearate, glyceryl monostearate, polyoxyethyl stearate, alkylphenol polyglycol ether, etc. Activators; amphoteric surfactants such as disodium N-lauryl-β-iminodipropionate and lecithin; anions such as sodium lauryl sulfate, fatty alcohol sulfate ether, monoethanolamine salt of mono / dialkyl polyglycol orthophosphate Surfactants; cationic surfactants such as cetyltrimethylammonium chloride.

  Other adjuvants include carboxymethyl cellulose, methyl cellulose, polyacrylate, alginate, gelatin, gum arabic, polyvinyl pyrrolidone, polyvinyl alcohol, methyl vinyl ether, a copolymer of maleic anhydride, polyethylene glycol, wax, colloidal silica.

  Semi-solid preparations can be administered by application on the skin or spreading or introduction into body cavities. Gels can be prepared by adding sufficient thickener to a solution prepared as described above for an injectable solution to produce a clear material having an ointment-like consistency.

  Next, formulation examples of the preparation when the compound of the present invention is used are shown. However, the formulation examples of the present invention are not limited to these. In the following formulation examples, “parts” means parts by weight.

[Wettable powder]
Compound of the present invention 0.1-80 parts Solid carrier 5-98.9 parts Surfactant 1-10 parts Others 0-5 parts Others include, for example, anti-caking agents and decomposition inhibitors.

[Milk]
Compound of the present invention 0.1 to 30 parts Liquid carrier 45 to 95 parts Surfactant 4.9 to 15 parts Others 0 to 10 parts Others include, for example, spreading agents, decomposition inhibitors and the like.

[Suspension]
Compound of the present invention 0.1 to 70 parts Liquid carrier 15 to 98.89 parts Surfactant 1 to 12 parts Others 0.01 to 30 parts Others include, for example, antifreezing agents and thickeners.

(Granule wettable powder)
Compound of the present invention 0.1 to 90 parts Solid carrier 0 to 98.9 parts Surfactant 1 to 20 parts Others 0 to 10 parts Others include, for example, binders and decomposition inhibitors.

(Liquid)
Compound of the present invention 0.01 to 70 parts Liquid carrier 20 to 99.99 parts Others 0 to 10 parts Other examples include antifreezing agents and spreading agents.

[Granule]
Compound of the present invention 0.01 to 80 parts Solid carrier 10 to 99.99 parts Others 0 to 10 parts Others include, for example, binders, decomposition inhibitors and the like.

[Dust]
Compound of the present invention 0.01 to 30 parts Solid support 65 to 99.99 parts Others 0 to 5 parts Other examples include a drift inhibitor and a decomposition inhibitor.

  Next, although the formulation example which uses this invention compound as an active ingredient is shown more concretely, this invention is not limited to these.

  In the following formulation examples, “parts” means parts by weight.

[Formulation Example 1] wettable powder Compound No. 1-102 of the present invention 20 parts pyrophyllite 74 parts Solpol 5039 4 parts (mixture of nonionic surfactant and anionic surfactant: Toho Chemical Co., Ltd.) Product name)
Carplex # 80D 2 parts (Synthetic hydrous silicic acid: Shionogi & Co., Ltd. trade name)
The above is uniformly mixed and ground to obtain a wettable powder.

[Formulation Example 2] Milk Compound of the present invention No.1-002 5 parts Xylene 75 parts N-methylpyrrolidone 15 parts Solpol 2680 5 parts (mixture of nonionic surfactant and anionic surfactant: Toho Chemical Industry (Product name)
The above is uniformly mixed to obtain an emulsion.

[Formulation Example 3] Suspension Agent Compound No. 1-002 25 parts Agrisol S-710 10 parts (Nonionic surfactant: trade name of Kao Corporation)
LUNOX 1000C 0.5 part (anionic surfactant: Toho Chemical Industries, Ltd. trade name)
Xanthan gum 0.2 parts water 64.3 parts After uniformly mixing the above, wet pulverize to make a suspension.

[Formulation Example 4] Granule wettable powder Compound No.1-002 of the present invention 75 parts Hytenol NE-15 5 parts (anionic surfactant: trade name of Daiichi Kogyo Seiyaku Co., Ltd.)
Vanillex N 10 parts (anionic surfactant: Nippon Paper Industries Co., Ltd. trade name)
Carplex # 80D 10 parts (Synthetic hydrous silicic acid: Shionogi & Co., Ltd. trade name)
After uniformly mixing and pulverizing the above, a small amount of water is added, stirred and mixed, granulated with an extrusion granulator, and dried to obtain a granulated wettable powder.

[Formulation Example 5] Granules Invention Compound No. 1-002 5 parts Bentonite 50 parts Talc 45 parts After uniformly mixing and pulverizing the above, a small amount of water is added and mixed with stirring, and granulated with an extrusion granulator. And dried into granules.

[Formulation Example 6] Powder Compound of the present invention No.1-002 3 parts Carplex # 80D 0.5 part (Synthetic hydrous silicic acid: Shionogi Pharmaceutical Co., Ltd. trade name)
Kaolinite 95 parts Diisopropyl phosphate 1.5 parts The above is uniformly mixed and ground to obtain a powder.

  In use, the above preparation is diluted 1 to 10000 times with water or sprayed directly without dilution.

[Formulation Example 7] wettable powder preparation Compound No. 1-002 of the present invention 25 parts sodium diisobutylnaphthalenesulfonate 1 part calcium n-dodecylbenzenesulfonate 10 parts alkylaryl polyglycol ether 12 parts naphthalenesulfonic acid formalin condensate Sodium salt 3 parts Emulsion type silicone 1 part Silicon dioxide 3 parts Kaolin 45 parts [Formulation Example 8] Water-soluble thickener preparation Compound No.1-002 20 parts Polyoxyethylene lauryl ether 3 parts Sodium dioctyl sulfosuccinate 3. 5 parts dimethyl sulfoxide 37 parts 2-propanol 36.5 parts [Formulation Example 9] Solution for spraying the present compound No.1-002 2 parts dimethyl sulfoxide 10 parts 2-propanol 35 parts acetone 53 parts [Formulation Example 10] transdermal Solution for administration The present compound No.1-002 5 Part hexylene glycol 50 parts Isopropanol 45 parts [Formulation Example 11] Solution for transdermal administration Compound No. 1-002 of the present invention 5 parts Propylene glycol monomethyl ether 50 parts Dipropylene glycol 45 parts [Formulation example 12] Transdermal administration (instillation) ) Solution for the Invention Compound No.1-002 2 parts Light Liquid Paraffin 98 parts [Formulation Example 13] Solution for the transdermal administration (dropping) Compound No. 1-002 2 parts Light Liquid Paraffin 58 parts Olive Oil 30 parts ODO -H 9 parts Shin-Etsu Silicone 1 part In addition, when the compound of the present invention is used as an agrochemical, other types of herbicides, various insecticides, acaricides, nematicides, You may mix and apply with a disinfectant, a plant growth regulator, a synergist, a fertilizer, a soil conditioner, etc.

  In particular, when mixed with other pesticides or plant hormones, the cost can be reduced by reducing the amount of applied medicine, the insecticidal spectrum can be expanded by the synergistic action of the mixed drugs, and higher pest control effects can be expected. At this time, a combination with a plurality of known agricultural chemicals is also possible. Examples of the type of agricultural chemical used in combination with the compound of the present invention include compounds described in the 2005 Crop Protection Handbook (Crop Protection Handbook). Specific examples of common names are as follows, but the general names are not necessarily limited to these.

  Bactericides: acibenzolar-S-methyl, acylaminobenzamide, acypetacs, aldimorph, amisulbrom, amobam, ampropyfos, Anilazine, azaconazole, azithiram, azoxystrobin, barium polysulfide, benalaxyl, benodanil, benomyl, benquinox , Benthaluron, benthiavalicarb, benthiazole, benzamacril, benzamorf, bethoxazine, binapacryl, biphenyl, bitertanol ,blast Idin-S (blasticidin-S), Bordeaux mixture, boscalid, bromoconazole, bupirimate, buthiobate, calcium polysulfide, captafol , Captan, carpropamid, carbamorph, carbendazim, carboxin, carvone, carvone, cheshunt mixture, chinomethionat, clobenazone (Chlobenthiazone), chloraniformethane, chloranil, chlorfenazol, chloroneb, chloropicrin, chlorothalonil, chlorquinox, clozolinate linate), climbazole, clotrimazole, copper acetate, basic carbonate, copper carbonate, copper hydroxide, copper naphthenate , Copper oleate, copper oxychloride, copper sulfate, copper sulfate, basic, copper zinc chromate, cufraneb, Cuprobam, cyazofamid, cyclafuramid, cycloheximide, cyflufenamid, cymoxanil, cypendazole, cyproconazol, din , Cyprofuram, dazomet, debacarb, decafenci Decafentin, dehydroacetic acid, dichlofluanid, dichlone, dichlorophen, dichlorophenoline, diclobutrazol, diclocymet, diclocymet, Diclomedine, dicloran, diethofencarb, difenoconazole, diflumetorim, dimethirimol, dimethomorph, dimethomorph, dimoxystrobin, dimoxystrobin M (diniconazole-M), dinobuton, dinocap, dinocap-4, dinocap-6, dinoton, dinosulfon, dinoterbon , Diphenylamine mine, dipyrithione, ditalimfos, dithianon, dodemorph, dodine, drazoxolone, edifenphos, epoxiconazole, etaconazole, eta Etem, ethirimol, ethoxyquin, etridiazole, famoxadone, fenarimol, febuconazole, fenamidone, fenaminosulf, fenilil ), Fendazosulam, fenfuram, fenhexamid, fenitropan, fenoxanil, fenpiclonil, fenpropidin, fenproidin Morph (fenpropimorph), fentin, ferbam, ferimzone, fluazinam, fludioxonil, flumetover, flumorph, flumorph, fluoroimide, fluotrimazole ( fluotrimazole), fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, flutolanil, flutriafol, folpet, fosetyl-aluminum ( fosetyl-aluminium, fuberidazole, fluralaxyl, furametpyr, furcarbanil, furcarbanil, furconazole, fluconazole-cis, furmecyclox, furmecyclox, fumeidyl Furphanate, glyodin, griseofulvin, guazatine, halacrinate, hexachlorobenzene, hexaconazole, hexylthiofos, hydroxyquinoline sulphate 8-hydroxyquinoline sulfate, hymexazol, imazalil, imibenconazole, iminoctadine, ipconazole, iprobenfos, iprodione, iprodione, iprodione isoprothiolane), isovaledione, kasugamycin, kresoxim-methyl, mancopper, mancozeb, maneb, mebe Mebenil, mecarbinzid, mepanipyrim, mepronil, metalaxyl, metalaxyl-M, metam, metazoxolon, metconazole, metconazole Sulfocarb (methasulfocarb), metfuroxam (methfuroxam), methyl isothiocyanate (methyl isothiocyanate), metiram (metiram), mettominostrobin (metominostrobin), metrafenone (metrafenone), metsulfofax (metsulfovax), milneb (milneb), microbutanil (milneb) (Myclobutanil), microzoline, nabam, natamycin, nickel bis (dimethyldithiocarbamate), nitrostyrene, nitrotar-isopropyl hal-isopropyl, nuarimol, OCH, octhilinone, ofurace, orysastrobin, oxadixyl, oxine copper, oxycarboxin , Oxpoconazole fumarate, pefurzoate, penconazole, pencycuron, penthiopyrad, ortho-phenylphenol, phosdiphen, phthalide ), Picoxystrobin, piperalin, polycarbamate, polyoxins, polyoxorim, potassium azide, potassium hydrogen carbonate, pro Naquinide, probenazole, prochloraz, procymidone, propamocarb hydrochloride, propiconcarb, propineazole, propineb, prothiocarb, prothioconazole ), Pyracarbolid, pyraclostrobin, pyrazophos, pyridinitril, pyrifenox, pyrimethanil, pyroquilon, pyroxycyclyl, poxylpy , Quinomethionate, quinoxyfen, quintozene, quinacetol-sulfate, quinazamid, quinconazole , Rabenzazole, sodium azide, sodium hydrogen carbonate, sodium hypochlorite, sulfur, spiroxamine, salicylanilide, silthiofam (Silthiofam), simeconazole, tebuconazole, tecnazene, tecoram, tetraconazole, thiabendazole, thiadifluor, thicyofen, thifluzamide thifluzamide, thiochlorfenphim, thiophanate, thiophanate-methyl, thioquinox, thiram, thiadinyl, tioxymid, Tolclofos-methyl, tolylfluanid, triadimefon, triadimenol, triamiphos, triarimol, triazoxide, triazoxide, triazbutil, tributyltin oxide (triazbutil) tributyltin oxide, trichlamide, tricyclazole, tridemorph, trifloxystrobin, triflumizole, triforine, triticonazole, validamycin Vinclozolin, zarilamide, zinc sulfate, zineb, ziram, zoxamide and shiitake mycelium extract.

  Bactericides: benzalkonium chloride, bithionol, bronopol, cresol, formaldehyde, nitrapyrin, oxolinic acid, oxyterracycline , Streptomycin and tecloftalam.

  Nematicides: aldoxycarb, cadusafos, DDBCP, dichlofenthion, DSP (DSP), etoprophos, fenamiphos, fensulfothion, fostiazeto (Fosthiazate), fosthietan, imiciafos, isamifos, isazofos, oxamyl and thionazin.

  Acaricide: acequinocyl, acrinathrin, amitraz, BCI-033 (test name), bifenazate, bromopropylate, chinomethionat, chlorobezilate , Clofentezine, cyenopyrafen, cyflumetofen, cyhexatine, dicofol, dienochlor, denochlor (DNOC), etoxazole, quinazaquin (fenaza) Fenbutatin oxide, fenothiocarb, fenpropathrin, fenpyroximate, fluacrypyrim, halfenprox (halfenpro) x), hexythiazox, milbemectin, propargite, pyridaben, pyrimidifen, S-1870 (test name), spirodiclofen, spiromesifen ( spyromesifen) and tebufenpyrad.

  Insecticides: abamectin, acephate, acetamipirid, alanycarb, aldicarb, allethrin, azinphos-methyl, bacillus thuringiensis ), Bendiocarb, benfuracarb, bensultap, bifenthrin, buprofezin, butocarboxim, carbaryl, carbofuran, carbosulfan , Cartap, chlorfenapyr, chlorfenvinphos, chlorfluazuron, chlorpyrifos, chlorpyrifos-methyl, chromafu Nozide (chromafenozide), clothianidin, cycloprothrin, cyflumetofen, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin Cypermethrin, cyromazine, deltamethrin, diacloden, diafenthiuron, diazinon, dichlorvos, diflubenzuron, dimethylvinphos , Dinotefuran, diofenolan, disulfoton, dimethoate, emamectin-benzoate, EPN, esfenvalerate (Esfenvalerate), etiofencarb, ethiprole, etofenprox, etrimfos, fenitrothion, fenobucarb, fenoxycarb, fenpropathrin, fenpropathrin (Fenthion), fenvalerate, fipronil, flonicamid, flubendiamide, flucythrinate, flufenerim, flufenoxuron, flufenprox ), Fulvalinate, tau-fluvalinate, fonophos, formetanate, formothion, furathiocarb, Halofenozide, hexaflumuron, hydramethylnon, imidacloprid, isofenphos, indoxacarb, isoprocarb, isoxathion, lepimectin (leme) , Lufenuron, malathion, metalaldehyde, metamidophos, methidathion, methacrifos, metaflumizone, metalcarb, methomyl, rene , Methoxychlor, methoxyfenozide, methyl bromide, monocrotophos, muscalure, nitenpyra m), NNI-0101 (test name), omethoate, oxamyl, oxydemeton-methyl, oxydeprofos, parathion, parathion-methyl , Pentachlorophenol (PCP), permethrin, phenthoate, phoxim, phorate, phosalone, phosmet, phosphamidon, pirimicarb , Pirimiphos-methyl, profenfos, prothiofos, propaphos, protrifenbute, pymetrozine, pyraclofos, pyridalyl, pyriproxy Fen (pyriprox yfen), rotenone, rynaxypyr, SI-0405 (study name), sulprofos, silafluofen, spinosad, sulfopep, SYJ-159 (study name), tebufenozide (Tebfenozide), teflubenzuron, tefluthorin, terbufos, tetrachlorovinphos, thiacloprid, thiocyclam, thiodicarb, thiamethoxam, thiamethoxam (Thiofanox), thiometon, tolfenpyrad, tralomethrin, trichlorfon, triazuron, triflumuron, and vamidothion.

  Hereinafter, the present invention will be described in more detail by specifically describing synthesis examples and test examples of the compounds of the present invention as examples, but the present invention is not limited thereto.

[Synthesis example]
Synthesis example 1
5- (3,5-dichlorophenyl) -3- (4-methylthiophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole (the present compound No.1-002).

Step 1: Preparation of 3,5-dichloro-1- (1-trifluoromethylethenyl) benzene To a solution of 25.0 g of 3,5-dichlorophenylboric acid in 200 ml of tetrahydrofuran and 100 ml of water, 2-bromo-3,3, 27.5 g of 3-trifluoropropene, 38.0 g of potassium carbonate and 1.84 g of dichlorobis (triphenylphosphine) palladium (II) were added, and the mixture was stirred for 3 hours while heating under reflux. After completion of the reaction, the mixture was allowed to cool to room temperature, 500 ml of ice water was added, and the mixture was extracted with ethyl acetate (500 ml × 1). The organic layer was washed with water, dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography eluting with hexane to obtain 25.7 g of the desired product as a colorless oil. It was.
¹ H NMR (CDCl ₃ , Me ₄ Si, 300 MHz) δ7.41 (t, J = 2.0Hz, 1H), 7.3-7.35 (m, 2H), 6.05 (q, J = 3.2Hz, 1H), 5.82 ( q, J = 3.2Hz, 1H).

Step 2: Preparation of 5- (3,5-dichlorophenyl) -3- (4-fluorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 4-fluorobenzaldoxime 2.09 g N, N -To a 45 ml solution of dimethylformamide, 2.14 g of N-chlorosuccinimide was added and stirred at 40 ° C for 2 hours. The reaction mixture was then ice-cooled, 3.60 g of 3,5-dichloro-1- (1-trifluoromethylethenyl) benzene prepared in Step 1 and 2.50 g of potassium bicarbonate were added, and the mixture was stirred at room temperature for 18 hours. Stirring was continued for an hour. After completion of the reaction, the reaction mixture was poured into 50 ml of ice water and extracted with ethyl acetate (50 ml × 2). The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Corporation medium pressure preparative device; YFLC-Wprep) eluting with ethyl acetate-hexane (0: 1 to 1: 4 gradient) 5.06 g was obtained as yellow crystals.
Melting point 94.0-96.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.45-7.7 (m, 4H), 7.42 (t, J = 1.8Hz, 1H), 7.1-7.2 (m, 2H), 4.07 (d, J = 17.2Hz, 1H), 3.68 (d, J = 17.2Hz, 1H).

Step 3; Preparation of 5- (3,5-dichlorophenyl) -3- (4-methylthiophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 5- (3,5-dichlorophenyl) -3- ( 4-fluorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 0.95 g in N, N-dimethylformamide 5 ml solution was added sodium thiomethoxide 0.21 g and stirred at room temperature for 24 hours. did. After completion of the reaction, the reaction mixture was poured into 20 ml of ice water and extracted with ethyl acetate (40 ml × 1). The organic layer was dehydrated and dried in the order of saturated brine and anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by medium pressure preparative liquid chromatography (Yamazen Corporation medium pressure preparative device; YFLC-Wprep) eluting with ethyl acetate-hexane (0: 1 to 1: 9 gradient) 0.59 g was obtained as white crystals.
Melting point 114.0-116.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.56 (d, J = 8.2Hz, 2H), 7.5-7.55 (m, 2H), 7.43 (t, J = 1.8Hz, 1H), 7.26 ( d, J = 8.4Hz, 2H), 4.07 (d, J = 17.2Hz, 1H), 3.68 (d, J = 17.2Hz, 1H), 2.51 (s, 3H).

Synthesis example 2
5- (3,5-dichlorophenyl) -3- (4-methylsulfinylphenyl) -5-trifluoromethyl-4,5-dihydroisoxazole (present compound No. 1-003).

To a solution of 0.41 g of 5- (3,5-dichlorophenyl) -3- (4-methylthiophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole (present compound No.1-002) in 4 ml of chloroform Under ice-cooling, 0.20 g of 3-chloroperbenzoic acid was added, and stirring was continued for another 2 hours at the same temperature. After completion of the reaction, the reaction mixture was diluted with 10 ml of ethyl acetate, washed with a saturated aqueous sodium hydrogen carbonate solution (2 ml × 1), dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. . The residue was purified by medium pressure preparative liquid chromatography (Yamazen Co., Ltd. medium pressure preparator; YFLC-Wprep) eluting with ethyl acetate-hexane (1: 1 to 1: 4 gradient). 0.34 g was obtained as a colorless resinous material.
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.84 (d, J = 8.4 Hz, 2H), 7.72 (d, J = 8.3 Hz, 2H), 7.5-7.55 (m, 2H), 7.43 ( t, J = 1.8Hz, 1H), 4.13 (d, J = 17.2Hz, 1H), 3.76 (d, J = 17.2Hz, 1H), 2.75 (s, 3H).

Synthesis example 3
5- (3,5-dichlorophenyl) -3- (4-methylsulfonylphenyl) -5-trifluoromethyl-4,5-dihydroisoxazole (the present compound No.1-004).

A solution of 1.21 g of 3,5-dichloro-1- (1-trifluoromethylethenyl) benzene and 1.17 g of α-chloro-4-methylsulfonylbenzaldoxime prepared in Step 1 of Synthesis Example 1 in 8 ml of tetrahydrofuran To the solution, 0.75 g of potassium hydrogen carbonate was added and stirred at room temperature for 18 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, 20 ml of ice water was added, and the mixture was extracted with ethyl acetate (100 ml × 1). Distilled off. The residual solid was washed with 10 ml of diisopropyl ether to obtain 1.93 g of the desired product as skin-colored crystals.
Melting point: 168.0-170.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ8.02 (d, J = 8.4 Hz, 2H), 7.88 (d, J = 8.3 Hz, 2H), 7.5-7.55 (m, 2H), 7.45 ( t, J = 1.8Hz, 1H), 4.12 (d, J = 17.2Hz, 1H), 3.75 (d, J = 17.2Hz, 1H), 3.08 (s, 3H).

Synthesis example 4
5- (3,5-dichlorophenyl) -3- (4-mercaptophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole (the present compound No.1-001).

Step 1: N, N-dimethyl-thiocarbamic acid-O- [4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] Preparation 5- (3,5-dichlorophenyl) -3- (4-hydroxyphenyl) -5-trifluoromethyl-4,5-dihydroisoxazole (3.8 g) and potassium hydroxide (1.1 g) in methanol (10 ml) were mixed with ice. Under cold stirring, 2.5 g of N, N-dimethyl-thiocarbamoyl chloride was added and stirred at room temperature for 16 hours. After completion of the reaction, the reaction mixture was poured into 60 ml of ice water, and the precipitated crystals were collected by filtration to obtain 4.1 g of a crude target product as white crystals.
Melting point 97.5-101.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.70 (d, J = 8.8Hz, 2H), 7.5-7.55 (m, 2H), 7.42 (t, J = 1.8Hz, 1H), 7.14 ( d, J = 8.8Hz, 2H), 4.08 (d, J = 17.2Hz, 1H), 3.70 (d, J = 17.2Hz, 1H), 3.45 (s, 3H), 3.36 (s, 3H).

Step 2: N, N-dimethyl-thiocarbamic acid-S- [4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] Preparation N, N-dimethyl-thiocarbamic acid-O- [4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] 4.1 g Was stirred at 250 ° C. for 30 minutes under a nitrogen atmosphere. After completion of the reaction, the residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 4 to 1: 1 gradient) to obtain 3.8 g of the desired product as a yellow resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.66 (d, J = 8.6Hz, 2H), 7.56 (d, J = 8.6Hz, 2H), 7.5-7.55 (m, 2H), 7.42 ( t, J = 1.8Hz, 1H), 4.06 (d, J = 17.2Hz, 1H), 3.69 (d, J = 17.2Hz, 1H), 3.10 (bs, 3H), 3.03 (bs, 3H).

Step 3; Preparation of 5- (3,5-dichlorophenyl) -3- (4-mercaptophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole N, N-dimethyl-thiocarbamic acid-S- [ To a solution of 4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] in 3.80 g of methanol was added 0.84 g of potassium hydroxide. And stirred at 50 ° C. for 2 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was poured into 30 ml of ice water, and concentrated hydrochloric acid was added to adjust to pH 2, followed by extraction with ethyl acetate (50 ml × 2). The organic layers were combined, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain 3.20 g of a crude desired product as pale yellow crystals.
Melting point: 144.0-148.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.45-7.7 (m, 4H), 7.42 (t, J = 1.8Hz, 1H), 7.1-7.2 (m, 2H), 4.07 (d, J = 17.2Hz, 1H), 3.68 (d, J = 17.2Hz, 1H).

Synthesis example 5
2- [4- [5- (3,5-Dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenylthio] -N- (2,2,2-trifluoroethyl) Acetamide (the present compound No. 1-028).

Step 1; Preparation of 2- [4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenylthio] acetic acid 5- (3,5-dichlorophenyl ) -3- (4-Mercaptophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole (the present compound No.1-001) 1.80 g and potassium carbonate 0.30 g of N, N-dimethylformamide To the 10 ml solution was added 0.57 g of chloroacetic acid and stirred at room temperature for 20 hours. After completion of the reaction, the reaction mixture was poured into 40 ml of ice water and extracted with diethyl ether (50 ml × 2). The organic layers were combined, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain 2.20 g of a crude target product as an orange resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ8.05 (bs, 1H), 7.58 (d, J = 8.8Hz, 2H), 7.5-7.55 (m, 2H), 7.42 (t, J = 1.8 Hz, 1H), 7.40 (d, J = 8.6Hz, 2H), 4.05 (d, J = 17.2Hz, 1H), 3.73 (s, 2H), 3.67 (d, J = 17.2Hz, 1H).

Step 2; 2- [4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenylthio] -N- (2,2,2-tri Preparation of fluoroethyl) acetamide 2- [4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenylthio] acetic acid 0.43 g and 2,2 Then, 0.27 g of 1- [3- (diethylamino) propyl] -3-ethylcarbodiimide hydrochloride was added to a solution of 0.10 g of 2-trifluoroethylamine in 5 ml of chloroform and stirred at room temperature for 5 hours. After completion of the reaction, the reaction mixture was washed with 10 ml of water, the organic layer was dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (0: 1 to 1: 3 gradient) to obtain 0.25 g of the desired product as pale yellow crystals.
Melting point: 166.0 to 168.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.60 (d, J = 8.4Hz, 2H), 7.5-7.55 (m, 2H), 7.42 (t, J = 1.8Hz, 1H), 7.29 ( d, J = 8.4Hz, 2H), 7.03 (t, J = 6.4Hz, 1H), 4.05 (d, J = 17.2Hz, 1H), 3.85-3.95 (m, 2H), 3.74 (s, 2H), 3.67 (d, J = 17.2Hz, 1H).

Synthesis Example 6
4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -N- (2,2,2-trifluoroethyl) benzenesulfonamide Invention compound No. 1-019).

Step 1: Preparation of 4-bromo-N- (2,2,2-trifluoroethyl) benzenesulfonamide To a solution of 2.13 g of 2,2,2-trifluoroethylamine and 2.97 g of triethylamine in 40 ml of chloroform, While stirring, 5.60 g of 4-bromobenzenesulfonyl chloride was added dropwise, and after completion of the dropwise addition, stirring was continued for another 19 hours at room temperature. After completion of the reaction, the reaction mixture was poured into 40 ml of water, the organic layer was separated, and the aqueous layer was extracted with 30 ml of chloroform. The organic layers were combined and back-extracted with 50 ml of 1N aqueous sodium hydroxide solution, and the aqueous layer was adjusted to pH 3 by adding concentrated hydrochloric acid and then extracted with 50 ml of chloroform. The chloroform layer was dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain 2.15 g of the crude desired product as pale yellow crystals.
Melting point: 145.0-146.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300MHz) δ7.74 (d, J = 8.8Hz, 2H), 7.67 (d, J = 8.8Hz, 2H), 5.12 (t, J = 6.9Hz, 1H) , 3.6-3.8 (m, 2H).

Step 2: Preparation of 4-formyl-N- (2,2,2-trifluoroethyl) benzenesulfonamide 4-Bromo-N- (2,2,2-trifluoroethyl) benzenesulfonamide 2.10 g of tetrahydrofuran To the 20 ml solution, 9.2 ml of n-butyllithium (1.6 M hexane solution) was added dropwise with stirring at -78 ° C. After completion of the dropwise addition, stirring was continued for 5 minutes at the same temperature. 2 ml of N-dimethylformamide was added dropwise, and after completion of the dropwise addition, stirring was continued for 20 minutes at the same temperature. After completion of the reaction, the reaction mixture was poured into 60 ml of ice water and extracted with ethyl acetate (20 ml × 3). The residue was purified by high performance liquid chromatography (column: Inertsil ODS) eluting with acetonitrile-water (4: 1) to obtain 1.19 g of the objective product as white crystals.

Step 3; 4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -N- (2,2,2-trifluoroethyl) benzenesulfone Preparation of Amide 4-Formyl-N- (2,2,2-trifluoroethyl) benzenesulfonamide 1.12 g and sodium acetate 0.55 g in ethanol-water (3: 1) 40 ml solution with stirring at room temperature. Then, 0.44 g of hydroxylamine hydrochloride was added and stirred at the same temperature for 2.5 hours. After completion of the reaction, the reaction mixture was poured into 40 ml of water and extracted with ethyl acetate (20 ml × 3). The solvent was distilled off under reduced pressure.

The residue was dissolved in 10 ml of 1,2-dimethoxyethane, 0.26 g of N-chlorosuccinimide was added and stirred at 70 ° C. for 70 minutes, and then the reaction mixture was allowed to cool to room temperature. The produced 3,5-dichloro-1- (1-trifluoromethylethenyl) benzene (0.46 g) and potassium hydrogen carbonate (0.77 g) were added, and stirring was continued for another 19 hours at room temperature. After completion of the reaction, the reaction mixture was poured into 30 ml of ice water and concentrated hydrochloric acid was added to adjust to pH 3, followed by extraction with ethyl acetate (20 ml × 3). The solvent was distilled off under. The residue was purified by high performance liquid chromatography (column: Inertsil ODS) eluting with acetonitrile-water (4: 1) to obtain 0.18 g of the objective product as yellow crystals.
Melting point: 173.0-174.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.93 (d, J = 8.7 Hz, 2H), 7.72 (d, J = 8.7 Hz, 2H), 7.45-7.55 (m, 3H), 5.22 ( bs, 1H), 4.10 (d, J = 17.2 Hz, 1H), 3.65-3.8 (m, 3H).

  This invention compound can be manufactured according to the said manufacturing method and an Example. Although the example of this invention compound manufactured like the synthesis example 1-the synthesis example 6 is shown in Table 5, this invention is not limited only to these.

In the table, the description of Et represents an ethyl group. Similarly, n-Pr or Pr-n represents a normal propyl group, i-Pr or Pr-i represents an isopropyl group, and Ph represents a phenyl group.
The aromatic heterocycles represented by D23-2a to D32-1g in the table each represent the following structure.

Further, in the table, the numbers representing the substitution positions of the substituents (X) _m and (Y) _n correspond to the positions of the numbers described in the following structural formula, respectively, Represents no substitution.

Furthermore, * 1 in the table means “resinous”.
Table 5

―――――――――――――――――――――――――――――――――――――――
No. (X) _m R ³ (Y) _n S (O) _r -LQ mp (℃)
―――――――――――――――――――――――――――――――――――――――
1-001 3,5-Cl ₂ CF ₃ − SH 144.0-148.0
1-002 3,5-Cl ₂ CF ₃ − SCH ₃ 114.0-116.0
1-003 3,5-Cl ₂ CF ₃ − S (O) CH ₃ * 1
1-004 3,5-Cl ₂ CF ₃ − SO ₂ CH ₃ 168.0-170.0
1-005 3,5-Cl ₂ CF ₃ − SEt * 1
1-006 3,5-Cl ₂ CF ₃ -SO ₂ Et 132.0-137.0
1-007 3,5-Cl ₂ CF ₃ − SPr-n * 1
1-008 3,5-Cl ₂ CF ₃ -SO ₂ Pr-n 133.0-137.5
1-009 3,5-Cl ₂ CF ₃ − SPr-i * 1
1-010 3,5-Cl ₂ CF ₃ -SO ₂ Pr-i 137.0-140.0
1-011 3,5-Cl ₂ CF ₃ − SCH ₂ (D32-1a) * 1
1-012 3,5-Cl ₂ CF ₃ − SCH ₂ C≡CH * 1
1-013 3,5-Cl ₂ CF ₃ − SC (O) N (CH ₃ ) ₂ 112.0-115.5
1-014 3,5-Cl ₂ CF ₃ − SPh 113.0-115.0
1-015 3,5-Cl ₂ CF ₃ − S (O) Ph 138.0-140.0
1-016 3,5-Cl ₂ CF ₃ − SO ₂ Ph 169.0-170.0
1-017 3,5-Cl ₂ CF ₃ − S (D23-2a) H 196.0-198.0
1-018 3,5-Cl ₂ CF ₃ − S [(D32-1g) -3-Cl-5-CF ₃ ] * 1
1-019 3,5-Cl ₂ CF ₃ -SO ₂ NHCH ₂ CF ₃ 173.0-174.0
1-020 3,5-Cl ₂ CF ₃ 2-CH ₃ SCH ₃ * 1
1-021 3,5-Cl ₂ CF ₃ 2-CH ₃ SO ₂ CH ₃ 174.0-175.0
1-022 3,5-Cl ₂ CF ₃ 2-CF ₃ SCH ₃ 144.0-145.0
1-023 3,5-Cl ₂ CF ₃ 2-CF ₃ S (O) CH ₃ 65.0-67.0
1-024 3,5-Cl ₂ CF ₃ 2-CF ₃ SO ₂ CH ₃ 162.0-163.0
1-025 3,5-Cl ₂ CF ₃ − SCH ₂ CF ₃ * 1
1-026 3,5-Cl ₂ CF ₃ − SCH ₂ C (O) OCH ₃ * 1
1-027 3,5-Cl ₂ CF ₃ − SCH ₂ CH ₂ C (O) OCH ₃ * 1
1-028 3,5-Cl ₂ CF ₃ − SCH ₂ C (O) NHCH ₂ CF ₃ 166.0-168.0
1-029 3,5-Cl ₂ CF ₃ − S (O) CH ₂ C (O) NHCH ₂ CF ₃ 195.0-210.0
1-030 3,5-Cl ₂ CF ₃ − SO ₂ CH ₂ C (O) NHCH ₂ CF ₃ 224.0-227.0
1-031 3,5-Cl ₂ CF ₃ − SCH ₂ CH ₂ C (O) NHCH ₂ CF ₃ * 1
―――――――――――――――――――――――――――――――――――――――
Table ¹ shows the ¹ H NMR data of the compounds of the present invention which have no melting point.

In addition, the description with (A) in the table represents the conditions (CDCl ₃ , Me ₄ Si, 300 MHz) measured at 300 MHz using tetramethylsilane as a standard substance in a deuterated chloroform solvent, and the description with (B) Represents the measurement conditions of (CDCl ₃ , Me ₄ Si, 400 MHz), respectively.
Table 6 ――――――――――――――――――――――――――――――――――――――――
No. ¹ H NMR
―――――――――――――――――――――――――――――――――――――――
1-005 (B) δ7.2-7.65 (m, 7H), 4.06 (d, J = 17.2Hz, 1H), 3.67 (d, J = 17.2Hz, 1H),
3.00 (q, J = 7.4Hz, 2H), 1.35 (t, J = 7.4Hz, 3H).
1-007 (B) δ7.2-7.65 (m, 7H), 4.06 (d, J = 17.2Hz, 1H), 3.67 (d, J = 17.2Hz, 1H),
2.95 (t, J = 7.1Hz, 2H), 1.71 (sxt, J = 7.1Hz, 2H), 1.05 (t, J = 7.1Hz, 3H).
1-009 (A) δ7.3-7.6 (m, 7H), 4.07 (d, J = 17.1Hz, 1H), 3.67 (d, J = 17.3Hz, 1H),
3.4-3.6 (m, 1H), 1.33 (d, J = 6.6Hz, 6H).
1-011 (A) δ8.54 (d, J = 4.7Hz, 1H), 7.1-7.7 (m, 10H), 4.32 (s, 2H),
4.03 (d, J = 17.1Hz, 1H), 3.64 (d, J = 17.3Hz, 1H).
1-012 (B) δ7.4-7.65 (m, 7H), 4.07 (d, J = 17.2Hz, 1H), 3.69 (d, J = 17.2Hz, 1H),
3.68 (d, J = 2.7Hz, 2H), 2.26 (t, J = 2.7Hz, 1H).
1-018 (B) δ8.41 (s, 1H), 7.4-7.8 (m, 8H), 4.11 (d, J = 17.0Hz, 1H),
3.72 (d, J = 17.2Hz, 1H).
1-020 (B) δ7.3-7.6 (m, 5H), 7.0-7.2 (m, 1H), 4.08 (d, J = 17.2Hz, 1H),
3.70 (d, J = 17.2Hz, 1H), 2.47 (s, 3H), 2.30 (s, 3H).
1-025 (A) δ7.63 (d, J = 9.7Hz, 2H), 7.4-7.55 (m, 5H), 4.07 (d, J = 17.3Hz, 1H),
3.68 (d, J = 17.3Hz, 1H), 3.50 (q, J = 9.6Hz, 2H).
1-026 (B) δ7.58 (d, J = 8.4Hz, 2H), 7.5-7.55 (m, 2H), 7.42 (t, J = 1.8Hz, 1H),
7.39 (d, J = 8.4Hz, 2H), 4.05 (d, J = 17.2Hz, 1H), 3.74 (s, 3H),
3.71 (s, 2H), 3.68 (d, J = 17.2Hz, 1H).
1-027 (B) δ7.57 (d, J = 8.8Hz, 2H), 7.5-7.55 (m, 2H), 7.42 (t, J = 1.8Hz, 1H),
7.34 (d, J = 8.8Hz, 2H), 4.06 (d, J = 17.2Hz, 1H), 3.70 (s, 3H),
3.67 (d, J = 17.2Hz, 1H), 3.23 (t, J = 7.5Hz, 2H), 2.67 (t, J = 7.5Hz, 2H).
1-031 (B) δ7.56 (d, J = 8.6Hz, 2H), 7.5-7.55 (m, 2H), 7.42 (t, J = 1.8Hz, 1H),
7.32 (d, J = 8.6Hz, 2H), 6.07 (t, J = 6.5Hz, 1H), 4.06 (d, J = 17.2Hz, 1H),
3.85-3.95 (m, 2H), 3.67 (d, J = 17.2Hz, 1H), 3.27 (t, J = 7.1Hz, 2H),
2.59 (t, J = 7.1Hz, 2H).
―――――――――――――――――――――――――――――――――――――――
[Test example]
Next, the usefulness of the compound of the present invention as a pest control agent will be specifically described in the following test examples, but the present invention is not limited to these.

Test Example 1 Insecticidal test against a diamondback moth A 10% emulsion of a compound of the present invention (depending on the compound, a 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. Soak kanran leaves in this chemical solution for about 10 seconds, air dry and place in a petri dish. 5 second instar larvae of Plutella xylostella are released in this petri dish, covered and covered in a constant temperature room at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the dead insect rate was calculated from the following formula. In addition, the test was performed by 2 continuous systems.

Death rate (%) = (Number of dead insects / Number of dead insects) × 100
As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No.1-001,1-002 ^* , 1-003 ^* , 1-004,1-005 ^* , 1-006 ^* , 1-007 to 01-015,1-019,1-020 ^* , 1-021 ~ 1-024,1-025 ^* , 1-028 ^* , 1-029 ^* , 1-030 ^* , 1-031 ^*

In addition, the above-mentioned ^* indicates that an insecticidal test was conducted using a chemical solution with a concentration of 100 ppm.

Test Example 2 Insecticidal test against Spodoptera litura 10% emulsion of the compound of the present invention (10% wettable powder depending on the compound) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. Soak kanran leaves in this chemical solution for about 10 seconds, air-dry and place in a petri dish, in which 5 second-instar larvae of Spodoptera litura are released per petri dish, capped and placed in a thermostatic chamber at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No.1-002 ^* , 1-003 ^* , 1-004,1-006,1-008,1-020 ^* , 1-021 to 1-224,1-025 ^* , 1-028 ^* , 1-029 ^* , 1-030 ^* , 1-031 ^* .

In addition, the above-mentioned ^* indicates that an insecticidal test was conducted using a chemical solution with a concentration of 100 ppm.

Test Example 3 Insecticidal test against Syringoptera: A 10% emulsion of the compound of the present invention (depending on the compound, a 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 100 ppm. Immerse kanran leaves in this solution for about 10 seconds, air-dry and place in a petri dish. In this, 5 second-instar larvae of Spodoptera exigua are released per petri dish, capped and placed in a thermostatic chamber at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
The present compound: No. 1-003.

Test Example 4 Insecticidal Test for Chahamaki A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder was tested) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 100 ppm. Immerse kanran leaves in this solution for about 10 seconds, air dry and place in a petri dish. In this, 5 second-instar larvae of Homona magnanima are released per petri dish, covered and placed in a constant temperature room at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
The compound of the present invention: No. 1-002 to 1-004, 1-023, 1-024.

Test Example 5 Insecticidal test against giant tobacco moth 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder was tested) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 100 ppm. Immerse kanran leaves in this chemical for about 10 seconds, air dry and place in a petri dish. Release 2 second-instar larvae of Helicopapa armigera per petri dish, cover and place in a constant temperature room at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. Note that the test was conducted in a 12-unit system.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
The compound of the present invention: No. 1-006, 1-007, 1-009, 1-011, 1-012, 1-018, 1-025, 1-028 to 1-030.

Test Example 6 Insecticidal test against citrus white thrips Place a wet filter paper on a 7 cm inner diameter styrol cup, place a bean leaf cut to the same diameter on it, and place 1 instar larvae of citrus thrips (Frankliniella occidentalis) per leaf Ten animals were inoculated. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 2 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No. 1-002, 1-003, 1-005, 1-006, 1-008 to 1-010, 1-020, 1-022 to 1-025, 1-027 to 1-031.

Test Example 7 Insecticidal test against southern blue thrips Place a wet filter paper on a 7 cm inner diameter styrol cup, place green beans cut to the same diameter on it, and place 10 adult thrips palmi per leaf Vaccinated. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 100 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 2 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No. 1-002 to 1-009, 1-023 to 1-025, 1-028 to 1-030.

Test Example 8 Insecticidal test against white-spotted beetle A 10% emulsion of the present compound (10% wettable powder depending on the compound) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. . Immerse rice leaf sheath in this solution for about 10 seconds, air-dry it, put it in a test tube, and release 5 first-instar larvae of Eysarcoris lewisi per test tube, and cover the lid with a sponge. And housed in a constant temperature room at 25 ° C. The number of dead insects after 2 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
This invention compound: No.1-005,1-006,1-023,1-028-1-031.

Test Example 9 Insecticidal test against green planthopper A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. Immerse rice leaf sheaths in this solution for about 10 seconds, air-dry them, put them in a test tube, and release 5 second-instar larvae of Nilaparvata lugens per test tube, cover them with a sponge, and cover with 25 sponges. Housed in a constant temperature room. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
The compound of the present invention: No. 1-002, 1-025, 1-028 to 1-030.

Test Example 10 Insecticidal test for silver leaf whitefly A tomato leaf (10 eggs / leaf) laid on a silver leaf whitefly (Bemisia argentifolii) was cut and placed on a 7 cm inner diameter styrol cup. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
This invention compound: No.1-002,1-003,1-023.

Test Example 11 Insecticidal test against peach aphid A moist absorbent cotton is laid on a glass petri dish with an inner diameter of 3 cm, and kanran leaves cut out to the same diameter are placed on it. did. One day later, a 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm. The chemical solution was sprayed (2.5 mg / cm ² ), covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
This invention compound: No.1-002,1-007,1-020,1-028,1-031.

Test Example 12 Insecticidal test against Aphididae A moist filter paper is placed on a 7 cm inner diameter styrol cup, and a green bean leaf cut out to the same diameter is placed on it, and the 1st instar larvae of Planococcus kraunhiae are placed per leaf. Ten animals were inoculated. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
The compound of the present invention: No. 1-002, 1-003, 1-005 to 1-009, 1-020, 1-022, 1-023, 1-028.

Test Example 13 Insecticidal test against cucumber potato beetle A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. Soak cucumber leaves in this chemical for about 10 seconds, air-dry and place in a petri dish. In this, 5 second-instar larvae of Aulacophora femoralis are released per petri dish, capped and placed in a constant temperature room at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No. 1-002 to 1-012, 1-019 to 1-025, 1-028 to 1-031.

Test Example 14 Insecticidal test against legume leaf fly A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. In this chemical solution, a 7 cm diameter kidney bean leaf (10 eggs / leaf) spawned by Liriomyza trifolii was immersed for about 10 seconds, air-dried, and then wetted filter paper laid on a 7 cm inner diameter styrol cup. It was placed on top, covered and housed in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
The compound of the present invention: No. 1-002, 1-003, 1-005, 1-006, 1-020, 1-023, 1-028 to 1-031.

Test Example 15 Insecticidal test against a spider mite A moist filter paper was laid on a styrene cup having an inner diameter of 7 cm, leaves of kidney beans cut to the same diameter were placed thereon, and 10 larvae of the spider mite (Tetranychus urticae) were inoculated per leaf. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compounds of the present invention: No. 1-002 to 1-006, 1-020 to 1-025, 1-028 to 1-031.

Test Example 16 Insecticidal test against citrus mite mites Put a damp filter paper on a 7 cm inner diameter styrol cup, place citrus leaves cut out on the same diameter, and inoculate 10 larvae of citrus mite (Aculops pelekassi) per leaf . A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 100 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
The compound of the present invention: No. 1-002 to 1-004, 1-020, 1-022, 1-023.

Test Example 17 Insecticidal test against chrysanthemum mites Laminated filter paper was placed on a 7 cm inner diameter styrol cup, and green beans cut out to the same diameter were placed thereon, and 10 adults of polyphagotarsonemus latus were inoculated per leaf. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 100 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 2 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
The present compound: No. 1-002, 1-003.

  The substituted isoxazoline compounds according to the present invention exhibit excellent pest control activity, particularly insecticidal / miticidal activity, and are extremely useful with little adverse effect on non-target organisms such as mammals, fish and beneficial insects. A compound.

Claims (9)

General formula (1):

[Wherein, A ¹ , A ² and A ³ each independently represents a carbon atom or a nitrogen atom,
G represents a benzene ring, a nitrogen-containing 6-membered aromatic heterocycle, a furan ring, a thiophene ring or a 5-membered aromatic heterocycle containing two or more heteroatoms selected from an oxygen atom, a sulfur atom and a nitrogen atom;
X is a halogen atom, nitro, azido, -SCN, -SF _5, cyano, C ₁ -C ₆ alkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl , optionally substituted by R ⁴ (C ₃ ~C ₈₎ cycloalkyl, E1～E18, optionally substituted by C ₂ -C _{6 ^{alkenyl, R 4 (C 2 ~C 6}} ) alkenyl, C ₅ ~ C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₂ -C ₆ alkynyl, optionally substituted by R ⁴ (C ₂ ~C _{6) ^{alkynyl, -OH, -OR 5, -OSO 2}} R 5 , -SH, -S (O) _r R ⁵ , -N (R ⁷ ) R ⁶ , -N = C (R ^7a ) R ^6a , -C (O) R ⁸ , -C (R ⁸ ) = NOH, -C (R ⁸ ) = NOR ⁹ , M3, M13, M23 to M26, M28 to M30, -C (O) OR ⁹ , -C (O) SR ⁹ , -C (O) NH ₂ , -C (O ) N (R ¹⁰ ) R ⁹ , -C (S) OR ⁹ , -C (S) SR ⁹ , -C (S) NH ₂ , -C (S) N (R ¹⁰ ) R ⁹ , -SO ₂ OR ⁹ , -SO ₂ NH ₂ , -SO ₂ N (R ¹⁰ ) R ⁹ , -Si (R ^11a ) (R ^11b ) R ¹¹ , phenyl, (Z) phenyl substituted by _p1 or D1 ~ When D represents an integer of 2 or more, each X may be the same as or different from each other;
Further, when two Xs are adjacent to each other, the two adjacent Xs are -CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ O-, -CH ₂ OCH _2- , -OCH ₂ O-, -CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -CH ₂ CH ₂ N (R ¹² )-, -CH ₂ N (R ¹² ) CH _2- , -CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH _2- , -CH ₂ OCH ₂ O-, -OCH ₂ CH ₂ O-, -OCH ₂ CH ₂ S-, -CH ₂ CH = CH-,- OCH = CH-, -SCH = CH-, -N (R ¹² ) CH = CH-, -OCH = N-, -SCH = N-, -N (R ¹² ) CH = N-, -N (R ¹² By forming N = CH-, -CH = CHCH = CH-, -OCH ₂ CH = CH-, -N = CHCH = CH-, -N = CHCH = N- or -N = CHN = CH- A 5-membered ring or a 6-membered ring may be formed together with the carbon atom to which each of two Xs is bonded. At this time, the hydrogen atom bonded to each carbon atom forming the ring is optionally substituted by Z. In addition, when simultaneously substituted with two or more Z, each Z may be the same as or different from each other,
Y is a halogen atom, nitro, azido, -SCN, -SF _5, cyano, C ₁ -C ₆ alkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl , optionally substituted by R ⁴ (C ₃ ~C ₈₎ cycloalkyl, E1~E18, C ₂ ~C ₆ alkinyl, optionally substituted by R ⁴ (C ₂ ~C ₆₎ alkynyl, -OH, -OR ⁵ , -OSO ₂ R ⁵ , -SH, -S (O) _r R ⁵ , -NH ₂ , -N (R ⁷ ) R ⁶ , -N (R ⁷ ) C (O) R ^8a , -C (R ⁸ ) = NOH, -C (R ⁸ ) = NOR ⁹ , -C (O) NH ₂ , -C (O) N (R ¹⁰ ) R ⁹ , -C (S) NH ₂ , -C (S ) N (R ¹⁰ ) R ⁹ , —Si (R ^11a ) (R ^11b ) R ¹¹ , phenyl, phenyl substituted by (Z) _p1 or D1 to D38, and when n represents an integer of 2 or more, Each Y may be the same as or different from each other,
Further, when two Ys are adjacent to each other, the two adjacent Ys are —CH ₂ CH ₂ CH ₂ —, —CH ₂ CH ₂ O—, —CH ₂ OCH ₂ —, —OCH ₂ O—, —CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -SCH ₂ S-, -CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH ₂ -,- By forming CH ₂ OCH ₂ O-, -OCH ₂ CH ₂ O-, -OCH ₂ CH ₂ S-, -SCH ₂ CH ₂ S-, -OCH = N- or -SCH = N- A 5-membered ring or a 6-membered ring may be formed together with the carbon atom to which each Y is bonded, and at this time, the hydrogen atom bonded to each carbon atom forming the ring may be optionally substituted by Z Furthermore, when two or more Z are substituted at the same time, each Z may be the same as or different from each other,
L represents a single bond or a C ₁ -C ₁₂ alkylene chain,
Q represents a hydrogen atom, C ₁ -C ₆ haloalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ alkynyl, C ₂ -C ₆ haloalkynyl, -N (R ²⁾ R ¹ , -C (O) N (R ² ) R ¹ , -C (S) N (R ² ) R ¹ or R ¹³ , or when the substituent Y is present at the adjacent position, LQ Together with Y -CH ₂ CH _2- , -CH ₂ CH ₂ CH _2- , -OCH _2- , -SCH _2- , -N (R ⁶ ) CH _2- , -OCH ₂ CH _2- , -CH ₂ OCH _2- , -SCH ₂ CH _2- , -CH ₂ SCH _2- , -N (R ⁶ ) CH ₂ CH _2- , -CH ₂ N (R ⁶ ) CH _2- , -CH = CH- Alternatively, by forming —N═CH—, a 5-membered ring or a 6-membered ring may be formed together with the atoms to which LQ and Y are bonded, and at this time, bonded to each carbon atom forming the ring. hydrogen atom may be optionally substituted halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, the oxo group or thioxo group,
R ¹ is hydrogen atom, cyano, optionally substituted by C ₁ -C ₁₂ alkyl, optionally substituted by R ¹³ (C ₁ ~C ₁₂₎ alkyl, C ₃ -C ₁₂ cycloalkyl, R ¹³ ( C ₃ -C ₁₂₎ cycloalkyl, E2~E5, E8, E11~E14, E17 , C 2 ~C 12 alkenyl, optionally substituted by R ¹³ (C ₂ ~C ₁₂₎ alkenyl, C ₅ -C ₁₄ cycloalkenyl, C ₅ -C ₁₄ halo cycloalkenyl, optionally substituted by C ₃ -C _{12 ^{alkynyl, R 13 (C 3 ~C 12}} ) ^{alkynyl, -C (O) R 14,} -C (R 14) = NOH, -C (R ¹⁴ ) = NOR ¹⁵ , M3, M13, M30, -C (R ¹⁴ ) = NN (R ¹⁷ ) R ¹⁶ , -C (O) OR ¹⁵ , -C (O) SR ¹⁵ , -C (O) N (R ¹⁷ ) R ¹⁶ , -C (S) OR ¹⁵ , -C (S) SR ¹⁵ , -C (S) N (R ¹⁷ ) R ¹⁶ , -C (= NR ¹⁷ ) OR ¹⁸ , M7, M17, M23, M26, -C (= NR ¹⁷ ) SR ¹⁸ , M9, M19, M24, M28, -C (= NR ¹⁷ ) N (R ^18a ) R ¹⁸ , M11, M21, M25, M29 , -OH, -OR ¹⁵ , -SR ¹⁵ , -SO ₂ R ¹⁵ , -SO ₂ N (R ¹⁷ ) R ¹⁶ , -N (R ¹⁷ ) R ¹⁶ , -N = C (R ^17b ) R ^16b ,- C (O) ON = C ( R ^17b ) R ^16b , -SN (R ²⁰ ) R ¹⁹ , phenyl, (Z) phenyl substituted by _p1 or D1-D38,
R ² is a hydrogen atom, cyano, C ₁ -C ₁₂ alkyl, (C ₁ -C ₁₂ ) alkyl optionally substituted by R ^13a , C ₃ -C ₁₂ cycloalkyl, C ₃ -C ₁₂ halocycloalkyl, E3~E5, E11~E13, C ₃ ~C ₁₂ alkenyl, optionally substituted by R ^13a (C ₃ ~C ₁₂₎ alkenyl, C ₅ -C ₁₄ cycloalkenyl, C ₅ -C ₁₄ halo cycloalkenyl, C ₃ -C ₁₂ alkynyl, optionally substituted by R ^13a (C _{3 ~C 12)} ^{alkynyl, -C (O) R 14a,} -C (O) OR 15a, -C (O) SR 15a, -C ( O) N (R ^17a ) R ^16a , -C (S) OR ^15a , -C (S) SR ^15a , -C (O) C (O) OR ^15a , -OH, -OR ¹⁵ , -SR ¹⁵ ,- SO ₂ R ^15a , -SO ₂ N (R ^17a ) R ^16a , -N (R ¹⁷ ) R ¹⁶ , -N = C (R ^17b ) R ^16b , -SN (R ²⁰ ) R ¹⁹ , phenyl or (Z) or represents phenyl which is substituted by _p1, or, R ² together with R ¹ = C (R ^2a) and or R ² to form a R ^1a and R ¹ together C ₂ -C to form a ₇ alkylene chain , Indicates that may form a 3-8 membered ring together with the nitrogen atom to which they are attached this case the alkylene chain an oxygen atom, it may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl groups, C ₁ -C ₆ haloalkyl groups, C ₁ -C ₆ alkoxy (C ₁ -C ₆₎ alkyl groups, C ₁ -C ₆ alkoxy group, -CHO groups, C ₁ -C ₆ alkylcarbonyl groups, C ₁ -C ₆ haloalkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, C ₁ -C ₆ haloalkoxycarbonyl groups, C ₁ -C ₆ alkylaminocarbonyl group, C ₁ -C ₆ halo alkylaminocarbonyl group, a phenyl group, (Z) optionally substituted by a phenyl group, a D32 group, a D33 group, a D34 group, a D35 group, an oxo group or a thioxo group substituted by _p1 ,
R ^1a represents a hydrogen atom, —OR ¹⁵ , —SR ¹⁵ , C ₁ -C ₆ alkylsulfonyl, —NH ₂ , C ₁ -C ₆ alkylamino or di (C ₁ -C ₆ alkyl) amino,
R ^2a is C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, phenoxy, phenoxy substituted by (Z) _p1 , C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, -SCH ₂ R ^13a, C ₃ ~C ₆ alkenylthio, C ₃ -C ₆ halo alkenylene thio, C ₃ -C ₆ alkynylthio, C ₃ -C ₆ halo alkynylene ^{thio, -SC (O) R 14a,} -SC (O) OR ^15a, phenylthio, (Z) phenylthio substituted by _p1, di (C ₁ -C ₆ alkyl) or represents amino or R ^14a, or, R ^2a is C ₄ -C ₅ alkylene chain together with R ^1a Or a C _{4 to} C ₅ alkenylene chain may be formed to form a 5- to 6-membered ring with the carbon atoms to be bonded, and this alkylene chain or alkenylene chain is an oxygen atom, sulfur atom or nitrogen atoms may contain 1 to 3, and halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ Haroaruki Le group, C ₁ -C ₆ alkoxy group, C ₁ -C ₆ haloalkoxy group, C ₁ -C ₆ alkylthio group may be optionally substituted by C ₁ -C ₆ haloalkylthio group, or R ^17b group,
R ³ represents a halogen atom, cyano, optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ⁴ ( C ₃ -C ₈₎ cycloalkyl, substituted E1~E18, C ₃ ~C ₆ alkenyl, optionally substituted by R ⁴ (C ₂ ~C ₆₎ alkenyl, C ₃ -C ₆ alkynyl, optionally by R ⁴ been (C ₂ ~C ₆₎ ^{alkynyl, -OR 5, -S (O)} r R 5, -N (R 10) R 9, -C (O) R 8, -C (R 8) = NOH, -C (R ⁸ ) = NOR ⁹ , M3, M13, M30, -C (O) OR ⁹ , -C (O) SR ⁹ , -C (O) NH ₂ , -C (O) N (R ¹⁰ ) R ⁹ , -C (S) OR ⁹ , -C (S) SR ⁹ , -C (S) NH ₂ , -C (S) N (R ¹⁰ ) R ⁹ , -Si (R ^11a ) (R ^11b ) R ^{11 represents} -P (O) (OR ²¹ ) ₂ , phenyl, phenyl substituted by (Z) _p1 or D1-D38;
D1 to D38 each represent an aromatic heterocycle represented by the following structural formula;

Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkoxy (C ₁ ~ C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, -OH, C ₁ ~C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ haloalkyl sulfonyloxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ Haroaruki Sulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, -NH _2, C ₁ ~C ₆ alkyl amino, di (C ₁ -C ₆ alkyl) amino, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C _{6 haloalkoxycarbonyl, -C (O) NH 2,} C 1 ~C 6 alkyl amino carbonyl, C ₁ -C ₆ haloalkylcarbonyl aminocarbonyl, di (C ₁ -C ₆ alkyl) aminocarbonyl, -C (S _{) NH 2, -S (O)} 2 NH 2, C 1 ~C 6 alkylaminosulfonyl, di (C ₁ -C ₆ alkyl) aminosulfonyl, phenyl optionally substituted by phenyl or halogen atom, p1, when p2, p3 or p4 represents an integer of 2 or more, each Z may be the same as or different from each other;
Further, when two Zs are adjacent to each other, the two adjacent Zs are -CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ O-, -CH ₂ OCH _2- , -OCH ₂ O-, -CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -CH ₂ CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH _2- , -CH ₂ OCH ₂ O- , -OCH ₂ CH ₂ O-, -CH ₂ CH ₂ CH ₂ S-, -OCH ₂ CH ₂ S- or -CH = CH-CH = CH- may form a 5- or 6-membered ring together with the carbon atom, this time, the hydrogen atoms bonded to each carbon atom forming the ring is a halogen atom, a cyano group, a nitro group, C ₁ -C ₄ alkyl group may be optionally substituted by C ₁ -C ₄ haloalkyl groups, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio group,
E1 to E18 each represent a saturated heterocyclic ring represented by the following structural formula;

R ⁴ is a halogen atom, cyano, C _{3 to} C ₈ cycloalkyl, C _{3 to} C ₈ halocycloalkyl, E1 to E18, —OH, —OR ⁵ , —SH, —S (O) _r R ⁵ , — N (R ⁷ ) R ⁶ , -N (R ⁷ ) C (O) R ^8a , -C (O) OR ⁹ , -C (O) N (R ¹⁰ ) R ⁹ , -Si (R ^11a ) (R ^11b ) represents R ¹¹ , phenyl, (Z) phenyl substituted by _p1 or D1-D38,
R ⁵ is optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ²⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ²⁴ (C ₃ ~C ₈ ) cycloalkyl, E2~E5, E11~E14, E17, C 2 ~C 6 alkenyl, optionally substituted by R ²⁴ (C ₂ ~C ₆₎ alkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl, optionally substituted by R ²⁴ (C ₃ ~C ₆₎ alkynyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, phenyl, (Z) _represents phenyl, D1, D2, D4-D6, D8-D10, D12-D19, D21, D23, D25, D27, D30-D37 or D38 substituted by _p1 ,
R ⁶ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ ^{haloalkynyl, -C (O) R 8,} -C (O) OR 9, -C (O) SR 9, - C (O) NH ₂ , -C (O) N (R ¹⁰ ) R ⁹ , -C (S) OR ⁹ , -C (S) SR ⁹ , -C (S) NH ₂ , -C (S) N (R ¹⁰ ) R ⁹ , -C (O) C (O) R ⁹ , -C (O) C (O) OR ⁹ , -OH, -SO ₂ R ⁹ , -SO ₂ N (R ¹⁰ ) R ⁹ , -P (O) (OR ²¹ ) ₂ or -P (S) (OR ²¹ ) ₂
R ^6a represents C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₃ -C ₆ alkenyloxy, phenoxy or phenoxy substituted by (Z) _p1 ;
R ⁷ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, -CHO, C ₁ -C ₆ alkylcarbonyl, or represents C ₁ -C ₆ haloalkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl, or , R ⁷ together with R ⁶ to form a C ₂ -C ₆ alkylene chain, it is possible to form a 3- to 7-membered ring with the nitrogen atom to which R ⁷ is bonded, oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, may be optionally substituted by oxo or thioxo group,
R ^7a represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ alkenyl, phenyl or phenyl substituted by (Z) _{p 1} , or R ^7a is R ^6a Together with C ₄ -C ₆ alkylene chain to form a 5- to 7-membered ring together with the carbon atoms to which it is bonded, wherein this alkylene chain is an oxygen atom or sulfur atom 1 May contain,
R ⁸ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E 3- E5, E11~E13, C ₃ ~C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl or C ₃ -C ₆ Represents haloalkynyl,
R ^8a represents phenyl, phenyl substituted by (Z) _p1 or D1-D38,
R ⁹ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E1-E18, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, represents phenyl, phenyl or D1~D38 substituted by (Z) _p1,
R ¹⁰ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₆₎ alkyl, or represents C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl, or, R ¹⁰ is R by forming a C ₂ -C ₆ alkylene chain together with ^9, it indicates that may form a 3- to 7-membered ring together with the nitrogen atom to which they are attached this case the alkylene chain an oxygen atom, a sulfur atom or nitrogen atoms may be one comprise, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group or a C ₁ -C ₆ alkoxycarbonyl Optionally substituted by a group,
R ¹¹ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, phenyl or phenyl substituted by (Z) _p1 ;
R ^11a and R ^11b each independently represent C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₆ alkoxy;
R ¹² is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxycarbonyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ haloalkoxycarbonyl (C ₁ -C ₄₎ alkyl, phenyl (C ₁ -C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ -C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ ~ C ₆ represents alkynyl, C ₃ -C ₆ haloalkynyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, phenyl substituted by phenyl or (Z) _p1,
Further, when Z is present at the adjacent position to R ¹² is, -CH ₂ and adjacent R ¹² and _{Z CH 2 CH 2 CH 2 -} , -CH = CH-CH = CH-, -N = CH- By forming CH = CH-, -CH = N-CH = CH-, -CH = CH-N = CH- or -CH = CH-CH = N-, a 6-membered ring is formed together with the atoms to which each is bonded. it may be formed, this time, the hydrogen atoms bonded to each carbon atom forming the ring may be optionally substituted by halogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl group ,
R ¹³ is a halogen atom, nitro, cyano, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, hydroxy (C ₃ -C ₈ ) cycloalkyl, C ₁ -C ₄ alkoxy (C ₃ -C ₈₎ cycloalkyl, E1~E18, C ₅ ~C ₁₀ cycloalkyl, C ₅ -C ₁₀ halo ^{cycloalkenyl, -OR 25, -N (R 26} ) R 25, -SH, -S (O) r R 27 , -C (O) R ²⁸ , -C (R ²⁸ ) = NOH, -C (R ²⁸ ) = NOR ²⁹ , -C (O) OH, -C (O) OR ²⁹ , -C (O) SR ²⁹ , -C (O) NH ₂ , -C (O) N (R ³⁰ ) R ²⁹ , -C (O) N (R ³⁰ ) OR ²⁹ , -C (O) N (R ³⁰ ) N (R ^29a ) R ²⁹ , -C (S) OR ²⁹ , -C (S) SR ²⁹ , -C (S) NH ₂ , -C (S) N (R ³⁰ ) R ²⁹ , -C (= NR ³⁰ ) OR ³¹ , -C (= NR ³⁰ ) SR ³¹ , -C (= NR ³⁰ ) N (R ^31a ) R ³¹ , -C (= NOR ²⁹ ) N (R ^31a ) R ³¹ , -C (O) C (O) OR ²⁹ , -SO ₂ OH, -SO ₂ NH ₂ , -SO ₂ N (R ³⁰ ) R ²⁹ , -Si (R ^11a ) (R ^11b ) R ¹¹ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , M1-M30, phenyl, (Z) phenyl, naphthyl or D1-D38 substituted by _p1 And
M1 to M30 each represents a partially saturated heterocyclic ring represented by the following structural formula,

R ^13a is a halogen atom, nitro, cyano, C ₃ -C ₈ cycloalkyl, -OR ²⁵ , -N (R ²⁶ ) R ²⁵ , -S (O) _r R ²⁷ , -C (O) R ²⁸ ,- C (R ²⁸ ) = NOR ²⁹ , -C (O) OR ²⁹ , -C (O) SR ²⁹ , -C (O) NH ₂ , -C (O) N (R ³⁰ ) R ²⁹ , -C (S ) OR ²⁹ , -C (S) SR ²⁹ , -C (S) NH ₂ , -C (S) N (R ³⁰ ) R ²⁹ , -C (O) C (O) OR ²⁹ , -Si (R ^11a ) (R ^11b ) R ¹¹ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ or phenyl,
R ¹⁴ and R ^14a are each independently a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³² , C ₃ -C ₈ cycloalkyl, C ₃ -C _{8 halocycloalkyl, E3~E5, E11~E13, C 2 ~C} 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₂ -C ₆ represents alkynyl, C ₂ -C ₆ haloalkynyl, phenyl, phenyl, naphthyl or D1~D38 substituted by (Z) _p1,
R ¹⁵ and R ^15a is substituted each independently C ₁ -C ₆ alkyl, optionally substituted by R ³² (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally by R ³² and (C ₃ ~C ₈₎ cycloalkyl, E2~E5, E11~E14, E17, C 2 ~C 6 alkenyl, optionally substituted by R ³² (C ₂ ~C ₆₎ alkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl, optionally substituted by R ³² (C ₃ ~C ₆₎ alkynyl, phenyl, phenyl substituted by (Z) _p1, D1, D2, D4 to D6, D8 to D10, D12 to D19, D21, D23, D25, D27, D30 to D37 or D38,
R ¹⁶ is a hydrogen atom, C ₁ -C ₆ alkyl, optionally substituted by R ³² (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally substituted by R ³² (C ₃ -C ₈₎ cycloalkyl, E2~E5, E11~E14, E17, C 2 ~C 6 alkenyl, optionally substituted by R ³² (C ₂ ~C ₆₎ alkenyl, C ₅ -C ₁₀ cycloalkenyl, C ₅ -C ₁₀ halo cycloalkenyl, C ₃ -C ₆ alkynyl, optionally substituted by R ³² (C ₃ ~C ₆₎ ^{alkynyl, -C (O) R 28,} -C (O) OR 29, -C (O) SR ²⁹ , -C (O) NH ₂ , -C (O) N (R ³⁰ ) R ²⁹ , -C (S) R ²⁸ , -C (S) OR ²⁹ , -C (S) SR ²⁹ _{, -C (S) NH 2,} -C (S) N (R 30) R 29, -SO 2 R 29, -SO 2 NH 2, -SO 2 N (R 30) R 29, -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , phenyl, (Z) phenyl substituted by _p1 or D1-D38,
R ^16a is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E 3- E5, E11~E13, C ₂ ~C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, phenyl, phenyl substituted by (Z) _p1, D1, D2, D4 to D6, D8 to D10, D12 to D19, D21, D23, D25, D27, D30 to D37 or D38,
R ^16b is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl , C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ ~C ₄₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, substituted by (Z) _p1 phenyl (C ₁ -C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, E1～E18, phenyl (C ₂ -C ₄₎ alkenyl, di (C ₁ -C ₆ alkyl) amino, phenyl, (Z) _p1 Represents phenyl or D1-D38 substituted by
R ¹⁷ and R ^17a are each independently a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ haloalkoxy (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ haloalkylthio (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfonyl (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₆₎ alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ ~C ₄₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, -C (O) R ²⁸ , -C (O) OR ²⁹ , -C (O) SR ²⁹ , -C (S) OR ²⁹ , -C (S) SR ²⁹ , C ₁ -C ₆ alkyl or a sulfonyl or C ₁ -C ₆ haloalkylsulfonyl, or, R ¹⁷ and R ¹⁶ , R ^17a together with R ^16a each form a C ₂ -C ₆ alkylene chain to form a 3- to 7-membered ring with the nitrogen atom to which R ^17a is bonded. is an oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₄ alkoxy (C ₁ -C ₄₎ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group may be optionally substituted by C ₁ -C ₆ alkylcarbonyl group or a C ₁ -C ₆ alkoxycarbonyl group,
R ^17b represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkylthio or di (C ₁ -C ₆ alkyl) amino, or R ^{17b and} R ^16b by forming a C ₃ -C ₅ alkylene chain together, it indicates that may form a 4-6 membered ring with the carbon atoms to which they are attached this case the alkylene chain an oxygen atom, a sulfur atom or a nitrogen may contain one atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, -CHO group, by C ₁ -C ₆ alkylcarbonyl group or a C ₁ -C ₆ alkoxycarbonyl group Optionally substituted,
R ¹⁸ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C _{1 ~C 4)} alkyl, C ₁ -C ₄ alkylsulfonyl (C _{1 ~C 4)} alkyl, cyano (C _{1 ~C 6)} alkyl, C ₃ -C ₆ alkenyl or C ₃ ~ C ₆ represents alkynyl
R ^18a represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ¹⁹ is C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₁ -C ₁₂ alkoxy (C ₁ -C ₁₂ ) alkyl, cyano (C ₁ -C ₁₂ ) alkyl, C ₁ -C ₁₂ alkoxycarbonyl (C ₁ ~C ₁₂₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ halo alkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, C ₁ -C ₁₂ alkylcarbonyl, C ₁ -C ₁₂ alkoxycarbonyl, -C (O) ON = C (CH 3) SCH 3, -C (O) ON = C (SCH ₃ ) C (O) N (CH ₃ ) ₂ represents phenyl or phenyl substituted by (Z) _p1 ,
R ²⁰ is C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₁ -C ₁₂ alkoxy (C ₁ -C ₁₂ ) alkyl, cyano (C ₁ -C ₁₂ ) alkyl, C ₁ -C ₁₂ alkoxycarbonyl (C ₁ ~C ₁₂₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ halo alkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, phenyl or (Z) or represents phenyl which is substituted by _p1, or, R ²⁰ together with R ¹⁹ C ₄ ~C ₇ alkylene By forming a chain, it represents that a 5- to 8-membered ring may be formed together with the nitrogen atom to be bonded, and at this time, the alkylene chain may contain one oxygen atom or sulfur atom, and C ₁ -C may be optionally substituted by ₄ alkyl or C ₁ -C ₄ alkoxy group,
R ²¹ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ²² is a halogen atom, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ -C ₆ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ -C ₄₎ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylamino, di (C ₁ -C ₄ alkyl) amino, C ₁ ~ C ₆ alkoxycarbonyl, phenyl or phenyl substituted by (Z) _{p 1} , and when q 1 to q 8 represent an integer of 2 or more, each R ²² may be the same as or different from each other Well, furthermore, when two R ²² are substituted on the same carbon atom, the two R ²² together are oxo, thioxo, imino, C ₁ -C ₆ alkylimino, C ₁ -C ₆ alkoxy It indicates that may form an imino or C ₁ -C ₆ alkylidene,
R ²³ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C optionally substituted by R ³² ₆ haloalkenyl, C ₃ -C ₆ alkynyl, -OH, benzyloxy, -CHO, -C (O) R 33, -C (O) OR 33, -C (O) SR 33, -C (O) NHR ³⁴ , -C (O) N (R ³⁴ ) R ³³ , -C (S) NHR ³⁴ , -C (S) N (R ³⁴ ) R ³³ , -SO ₂ R ³³ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , phenyl, (Z) phenyl substituted by _p1 or D3,
R ²⁴ is halogen atom, cyano, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E1~E18, C ₁ ~C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, C ₁ -C ₆ alkylamino, di (C ₁ -C ₆ alkyl) amino, -CHO, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, C ₁ -C ₆ alkylaminocarbonyl, di (C ₁ -C ₆ alkyl) amino Represents carbonyl, phenyl, phenyl substituted by (Z) _p1 or D1-D38;
R ²⁵ is a hydrogen atom, C ₁ -C ₈ alkyl, optionally substituted by R ³² (C ₁ ~C ₈₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally substituted by R ³² (C ₃ -C ₈₎ cycloalkyl, E2~E5, E11~E14, E17, C 3 ~C 8 alkenyl, optionally substituted by R ³² (C ₃ ~C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, R ³² optionally substituted by (C ₃ ~C ₈₎ alkynyl, -CHO, -C (O) R 33, -C (O) OR 33, -C (O) SR 33, -C (O) NHR 34, -C (O) N (R ³⁴ ) R ³³ , -C (S) R ³³ , -C (S) OR ³³ , -C (S) SR ³³ , -C (S) NHR ³⁴ , -C (S) N (R ³⁴ ) R ³³ , -C (O) C (O) R ³³ , -C (O) C (O) OR ³³ , -SO ₂ R ³³ , -SO ₂ N (R ³⁴ ) R ³³ ,- Si (R ^11a ) (R ^11b ) R ¹¹ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , phenyl, (Z) phenyl substituted by _p1 , D1, D2, D4 to D6, D8 to D10, D12 to D19, D21, D23, D25, D27, D30 to D37 or D38,
R ²⁶ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, C ₁ -C ₆ alkoxy, phenyl or phenyl substituted by (Z) _{p 1} or R ²⁶ is By forming a C ₂ -C ₅ alkylene chain together with R ²⁵ , this means that a 3- to 6-membered ring may be formed together with the nitrogen atom to be bonded, and this alkylene chain is an oxygen atom, sulfur It may contain one to an atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, a phenyl group, a phenyl group substituted by (Z) _p1, also oxo group It may be substituted by a thioxo group,
R ²⁷ is optionally substituted by C ₁ -C ₈ alkyl, optionally substituted by R ³² (C ₁ ~C ₈₎ alkyl, C ₃ -C ₈ cycloalkyl, R ³² (C ₃ ~C ₈ ) cycloalkyl, E2~E5, E11~E14, E17, C 3 ~C 8 alkenyl, optionally substituted by R ³² (C ₃ -C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, optionally by R ³² substituted (C ₃ ~C ₈₎ alkynyl, -CHO, -C (O) R 33, -C (O) OR 33, -C (O) SR 33, -C (O) NHR 34, -C ( O) N (R ³⁴ ) R ³³ , -C (S) R ³³ , -C (S) OR ³³ , -C (S) SR ³³ , -C (S) NHR ³⁴ , -C (S) N (R ^{34) R 33, -C (O} ) C (O) R 33, -C (O) C (O) OR 33, -SH, C 1 ~C 6 alkylthio, C ₁ -C ₆ haloalkylthio, phenylthio, ( phenylthio substituted by _{Z) p1, -P (O)} (OR 21) 2, -P (S) (OR 21) 2, phenyl, phenyl substituted by _{(Z) p1, D9, D10} , D12, D14 ~ Represents D17, D30, D32 or D34,
R ²⁸ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ haloalkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylsulfonyl (C _{1 ~C 4)} alkyl, C ₁ -C ₆ haloalkylsulfonyl (C _{1 ~C 4)} alkyl, phenyl (C _{1 ~C 4)} alkyl, phenyl substituted by (Z) _p1 (C ₁ ~C ₄₎ represents alkyl, C ₃ -C ₆ cycloalkyl, phenyl substituted by phenyl or (Z) _p1,
R ²⁹ is optionally substituted by C ₁ -C ₈ alkyl, optionally substituted by R ³² (C ₁ ~C ₈₎ alkyl, C ₃ -C ₈ cycloalkyl, R ³² (C ₃ ~C ₈ ) cycloalkyl, E1 to E6, E11 to E14, E17, C ₂ -C ₈ alkenyl, optionally substituted by R ³² (C ₂ -C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, optionally by R ³² represents substituted (C ₃ ~C ₈₎ alkynyl, phenyl, phenyl or D1~D38 substituted by (Z) _p1,
R ³⁰ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³² , C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, or represents phenyl which is substituted by phenyl or (Z) _p1, or by R ³⁰ to form a C ₂ -C ₅ alkylene chain together with R ²⁹ Represents that a 3- to 6-membered ring may be formed together with the nitrogen atom to be bonded, in which case the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, optionally by phenyl substituted by phenyl or (Z) _p1 May be replaced,
R ³¹ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C _{1 ~C 4)} alkyl, C ₁ -C ₄ alkylsulfonyl (C _{1 ~C 4)} alkyl, cyano (C _{1 ~C 6)} alkyl, C ₃ -C ₆ alkenyl or C ₃ ~ C ₆ represents alkynyl
R ^31a represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ³² is a halogen atom, nitro, cyano, C _{3 to} C ₈ cycloalkyl, C _{3 to} C ₈ halocycloalkyl, E3, E4, E6, E7, E9, E11, E12, E14, E15, E17, C ₂ -C ₆ alkenyl, C ₂ -C ₆ ^{haloalkenyl, -OH, -OR 33, -OC (} O) R 33, -OC (O) OR 33, -OC (O) NHR 34, -OC (O) N (R ³⁴ ) R ³³ , -OC (S) NHR ³⁴ , -OC (S) N (R ³⁴ ) R ³³ , -SH, -S (O) _r R ³³ , -SC (O) R ³³ , -SC (O) OR ³³ , -SC (O) NHR ³⁴ , -SC (O) N (R ³⁴ ) R ³³ , -SC (S) NHR ³⁴ , -SC (S) N (R ³⁴ ) R ³³ , -NHR ³⁴ , -N (R ³⁴ ) R ³³ , -N (R ³⁴ ) CHO, -N (R ³⁴ ) C (O) R ³³ , -N (R ³⁴ ) C (O) OR ³³ , -N (R ³⁴ ) C (O) NHR ^33a , -N (R ³⁴ ) C (O) N (R ^33a ) R ³³ , -N (R ³⁴ ) C (S) NHR ^33a , -N (R ³⁴ ) C (S) N (R ^33a ) R ³³ , -CHO, -C (O) R ³³ , -C (O) OH, -C (O) OR ³³ , -C (O) SR ³³ , -C (O) NHR ³⁴ ,- C (O) N (R ³⁴ ) R ³³ , -C (O) C (O) OR ³³ , -Si (R ^11a ) (R ^11b ) R ¹¹ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , phenyl, phenyl substituted by (Z) _p1 or D1-D38,
R ³³ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³⁵ , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocyclo. alkyl, C ₂ -C ₆ alkenyl (C ₃ ~C ₈₎ cycloalkyl, C ₂ -C ₆ haloalkenyl (C ₃ ~C ₈₎ cycloalkyl, E3, E4, E11, E12 , C 2 ~C 8 alkenyl, C ₂ -C ₈ haloalkenyl, C ₃ -C ₈ cycloalkenyl, C ₃ -C ₈ halocycloalkyl cycloalkenyl, C ₂ -C ₈ alkynyl, C ₂ -C ₈ haloalkynyl, substituted phenyl, the (Z) _p1 Represents phenyl or D1-D38,
R ^33a and R ³⁴ are each independently a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₈ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, phenoxycarbonyl, phenoxycarbonyl substituted by (Z) _p1, phenylcarbonyl, (Z) phenylcarbonyl substituted by _p1, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, phenyl, phenyl substituted by _{(Z) p1, D1, D2} , D4~D6, D8~D10 D12-D19, D21, D23, D25, D27, D30-D37 or D38, or R ^33a and R ³⁴ together with R ³³ form a C ₂ -C ₅ alkylene chain, Forming a 3-6 membered ring with the nitrogen atom Represents good, this time the alkylene chain an oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, may be optionally substituted by a phenyl group substituted by a phenyl group or (Z) _p1,
R ³⁵ represents cyano, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, E3, E4, E11, E12 , C 1 ~C 4 alkoxy, C ₁ -C ₄ haloalkoxy, phenoxy, (Z ) _p1 phenoxy substituted by, C ₁ -C ₄ alkylthio, C ₁ -C ₄ haloalkylthio, phenylthio, (Z) phenylthio substituted by _p1, C ₁ -C ₄ alkylsulfonyl, C ₁ -C ₄ haloalkylsulfonyl , phenylsulfonyl, (Z) phenylsulfonyl substituted by ^{_{p1, -N (R 37) R}} 36, C 1 ~C 6 alkyl carbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, di ( C ₁ -C ₆ alkyl) aminocarbonyl, tri (C ₁ -C ₄ alkyl) silyl, phenyl, phenyl, naphthyl or D1~D38 substituted by (Z) _p1,
R ³⁶ is phenyl substituted by a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, phenylcarbonyl or (Z) _p1 Represents carbonyl,
R ³⁷ represents a hydrogen atom or C ₁ -C ₆ alkyl,
m represents an integer of 0 to 5;
n represents an integer of 0 to 4,
p1 represents an integer of 1 to 5,
p2 represents an integer of 0 to 4,
p3 represents an integer of 0 to 3,
p4 represents an integer of 0 to 2,
p5 represents an integer of 0 or 1,
q1 represents an integer of 0 to 3,
q2 represents an integer of 0 to 5,
q3 represents an integer of 0 to 7,
q4 represents an integer of 0 to 9,
q5 represents an integer of 0 to 6,
q6 represents an integer of 0 to 4,
q7 represents an integer of 0 to 2,
q8 represents an integer of 0 to 8,
r represents an integer of 0 to 2;
t represents an integer of 0 or 1. ]
Or a salt thereof. A ¹ represents a carbon atom or a nitrogen atom,
A ² and A ³ represent a carbon atom,
G represents a benzene ring,
X is a halogen atom, nitro, -SF _5, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ ~C ₆₎ haloalkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₆ ) Haloalkyl, C ₃ -C ₈ halocycloalkyl, —OR ⁵ , —OSO ₂ R ⁵ or —S (O) _r R ^5, and when m represents 2 or 3, each X is identical to each other. Or they may be different from each other,
Y is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, optionally substituted by R _⁴ (C ₁ ~C ⁴⁾ alkyl, -OR ^5, -SR ^5, - NH ₂ , —N (R ⁷ ) R ⁶ or —C (S) NH _2, and when n represents ₂ , each Y may be the same as or different from each other,
L represents a single bond or a C ₁ -C ₆ alkylene chain,
Q represents a hydrogen atom, C ₁ -C ₆ haloalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ ^{alkynyl, -N (R 2) R 1} , -C (O) N (R 2) R 1 or R ¹³
R ¹ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl, C ₃ -C ₆ cycloalkyl, E 3, E 4, E 11, C ₂ -C ₆ alkenyl, optionally substituted by R ¹³ ₂ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₁ -C ₆ ^{alkylcarbonyl, -CH = NOR 15, -C (} O) OR 15, -C (O) NH 2, -C (O) N (R ¹⁷ ) R ¹⁶ , -C (S) N (R ¹⁷ ) R ¹⁶ , M9, -N (R ¹⁷ ) R ¹⁶ , phenyl, phenyl substituted by (Z) _p1 , D5-D8, D10, D17 , D32-D34 or D35,
R ² is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, -CH ₂ R ^13a , C ₃ -C ₆ cycloalkyl, E3, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl , -C (O) represents R ^14a, -C (O) oR ^15a, -C a (O) C (O) oR 15a or C ₁ -C ₆ haloalkylthio,
R ³ represents C ₁ -C ₆ haloalkyl or C ₃ -C ₈ halocycloalkyl,
Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ haloalkylsulfonyloxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C _{6 alkylsulfonyl, -C (O) NH 2,} -C (S) NH 2 or -S (O ) ₂ NH ₂ and when p1, p2 or p3 represents an integer of 2 or more, each Z may be the same as or different from each other;
R ⁴ is, -OH, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ haloalkoxy, a C ₁ -C ₆ alkylthio or C ₁ -C ₆ haloalkylthio,
R ⁵ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₃ haloalkoxy (C ₁ -C ₃ ) haloalkyl,
R ⁶ is, C ₁ -C ₆ alkyl, -CHO, C ₁ ~C ₆ alkyl carbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ alkylthiocarbonyl, C ₁ -C ₆ alkoxythiocarbonyl, C ₁ -C ₆ alkyl dithio carbonyl, represents C ₁ -C ₆ alkylsulfonyl or C ₁ -C ₆ haloalkylsulfonyl,
R ⁷ represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ¹² represents a hydrogen atom, C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ¹³ is a halogen atom, cyano, C ₃ -C ₆ cycloalkyl, E3, E6, E14, -OR 25, -N (R 26) R 25, -S (O) r R 27, C 1 ~C 6 By alkylcarbonyl, -C (R ²⁸ ) = NOH, -C (R ²⁸ ) = NOR ²⁹ , -C (O) N (R ³⁰ ) R ²⁹ , -C (S) NH ₂ , phenyl, (Z) _p1 Represents substituted phenyl, D1, D5-D8, D10, D13, D16, D17, D22, D32-D34 or D35;
R ^13a represents cyano, -OR ²⁵ or -NHC (O) OR ³³ ,
R ^14a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkenyl, phenyl, (Z) represents phenyl or D32 substituted by _p1 ,
R ¹⁵ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ^15a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl, C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkenyl or C ₂ -C ₆ alkynyl,
R ¹⁶ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl, optionally substituted by R ³² , C ₃ -C ₈ cycloalkyl, C ₂ -C ₆ alkenyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, C ₁ -C ₆ haloalkylcarbonyl aminocarbonyl, phenylcarbonyl, phenyl, (Z) represents phenyl, D32, D33 or D34 substituted by _p1 ,
R ¹⁷ represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl or C ₁ -C ₆ alkylcarbonyl,
R ²² represents C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ²⁵ represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, -C (O) R ³³ or -C (O) OR ³³ ,
R ²⁶ represents a hydrogen atom, C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ²⁷ is, C ₁ -C ₆ represents alkyl, a C ₁ -C ₆ haloalkyl or C ₁ -C ₆ alkylcarbonyl,
R ²⁸ represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ²⁹ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl or phenyl,
R ³⁰ represents a hydrogen atom, C ₁ -C ₆ alkyl or C ₃ -C ₆ alkenyl,
R ³² represents C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkylthio, phenyl, phenyl substituted by (Z) _p1 or D32,
R ³³ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₃ -C ₆ cycloalkyl,
m represents an integer of 1 to 3,
n represents an integer of 0 to 2,
p1 represents an integer of 1 to 3,
p2 and p3 represent an integer of 0 to 2,
p4 represents an integer of 0 or 1,
q2 represents an integer of 0 to 2,
q3 and q4 represent 0,
The isoxazoline-substituted benzamide compound or a salt thereof according to claim 1, wherein q6 represents an integer of 0 or 1. X is a halogen atom, nitro, cyano, C ₁ -C ₆ represents alkyl, C ₁ -C ₆ haloalkyl, the -OR ⁵ or -S (O) _{r R} ^5, when m is 2 or 3, each of the X may be the same as or different from each other;
Y is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, -OR ^5, -SR ^5, an -NH ₂ or -N (R ⁷⁾ R ^6,
Q is substituted, hydrogen atom, C ₁ -C ₆ haloalkyl, C ₂ -C ₆ ^{alkynyl, -N (R 2) R 1} , -C (O) N (R 2) R 1, phenyl, with (Z) _p1 Represented phenyl, D10, D32 or D34,
Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, a C ₁ -C ₆ alkoxy or C ₁ -C ₆ alkylsulfonyloxy, p1 indicates an integer of 2 or more Each Z may be the same as or different from each other,
R ¹ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl,
R ² represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ³ represents C ₁ -C ₆ haloalkyl,
R ⁵ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ⁶ represents C ₁ -C ₆ alkyl, —CHO, C ₁ -C ₆ alkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl,
n represents an integer of 0 or 1,
p1 represents an integer of 1 or 2,
p2 and p3 represent an integer of 0 or 1,
The substituted isoxazoline compound or a salt thereof according to claim 2, wherein t represents 0. A ¹ represents a carbon atom,
X is a halogen atom or a C ₁ -C ₆ haloalkyl, when m is 2 or 3, each X may be the or different from each other the same as each other,
Y represents a halogen atom, C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
L represents a single bond or a C ₁ -C ₃ alkylene chain,
Q represents a hydrogen atom, C ₁ -C ₃ haloalkyl or ^{-C (O) N (R 2} ) represents R ^1,
R ¹ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ² represents a hydrogen atom,
The substituted isoxazoline compound or a salt thereof according to claim ₃ , wherein R ³ represents -CF ₃ or -CF ₂ Cl. General formula (2):

[Wherein A ¹ represents a carbon atom or a nitrogen atom,
J represents a hydrogen atom or a halogen atom,
Y represents a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, the -OR ⁵ or -N (R ⁷⁾ R ^6,
L represents a single bond or a C ₁ -C ₆ alkylene chain,
Q is substituted, hydrogen atom, C ₁ -C ₆ haloalkyl, C ₂ -C ₆ alkynyl, -C (O) N (R 2) R 1, -N (R 2) R 1, phenyl, with (Z) _p1 Represented phenyl, D10, D32 or D34,
D10, D32 and D34 each represent an aromatic heterocyclic ring represented by the following structural formula,

Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, a C ₁ -C ₆ alkoxy or C ₁ -C ₆ alkylsulfonyloxy, p1 indicates an integer of 2 or more Each Z may be the same as or different from each other,
R ¹ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl,
R ² represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ³ represents C ₁ -C ₆ haloalkyl,
R ⁵ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ⁶ represents -CHO, C ₁ -C ₆ alkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl,
R ⁷ represents a hydrogen atom or C ₁ -C ₆ alkyl,
n represents an integer of 0 or 1,
p1 represents an integer of 1 or 2,
p2, p3 and p4 represent an integer of 0 or 1,
t represents 0. ]
A 4-substituted benzaldoxime compound represented by the formula: A pest control agent comprising one or more selected from the substituted isoxazoline compounds and salts thereof according to claim 1 as active ingredients. An agrochemical containing one or more selected from the substituted isoxazoline compounds and salts thereof according to claim 1 as active ingredients. A mammalian or avian internal or ectoparasite control agent comprising, as an active ingredient, one or more selected from the substituted isoxazoline compounds and salts thereof according to claim 1. An insecticide or acaricide containing one or more selected from the substituted isoxazoline compounds and salts thereof according to claim 1 as active ingredients.