JP2009195559A - Needle-integrated measuring device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an inexpensive and compact needle-integrated measuring device capable of easily miniaturizing a drive mechanism to simultaneously drive a puncture implement and a biosensor chip for puncture, capable of easy puncture, and capable of accurate measurement. <P>SOLUTION: The needle-integrated measuring device 1 comprises a connector 32 and the drive mechanism 51. A biosensor cartridge 11 having integrated puncture needle 13 and biosensor chip 20 is detachably attached to the connector 32. The connector 32 is driven by the drive mechanism 51 for puncture for a measuring device body 40. The drive mechanism 51 comprises: a crank plate 59 to be rotationally driven by a drive motor 53; an eccentric shaft 54 disposed in the crank plate 59; and a first crank rod 55 connected to the eccentric shaft 54 to reciprocate the connector 32 at the speed corresponding to the speed of rotation of the crank plate 59. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a needle-integrated measuring apparatus, for example, a needle-integrated measuring apparatus that performs chemical substance measurement and analysis using a reagent contained in a biosensor chip.

  For example, a blood glucose measurement device used for early detection and prevention of deterioration of diabetes is used for blood glucose measurement many times a day, so that the puncture device and the measurement device are integrated and the blood is squeezed out. It is preferable that a suction means is provided. As this type of blood glucose measurement device, for example, a component measurement device disclosed in Patent Document 1 is known.

The component measuring apparatus described in Patent Literature 1 and the like mainly includes a main body, a lid, a finger pad, a puncturing unit housed in a housing, a pump, and a measuring unit.
In use, the chip is mounted on the housing, and the tip of the chip is sealed by pressing the fingertip against the finger pad. When the operation button is pressed, the puncture needle provided on the chip punctures the fingertip, the pump places the inside of the housing and the puncture site in a depressurized state, blood is sucked out from the puncture site, and predetermined components in the collected blood are measured. And measured by the control means, and the result is displayed on the display unit.

The puncturing means (drive mechanism) of such a component measuring device includes a plunger with a puncture needle detachably fitted to the tip, a puncture spring that biases the plunger in the tip direction, and a plunger in the proximal direction. And a pushing-back spring.
When the operation button is pressed, the puncture spring expands to move the plunger in the distal direction, and the cutting edge of the puncture needle punctures the surface of the fingertip.

  At this time, the push-back spring is compressed and biases the plunger in the proximal direction, that is, tries to push the plunger back in the proximal direction. Thereafter, the plunger dampens and stops at a position where the elastic force of the puncture spring and the elastic force of the push-back spring balance. When the plunger is stationary, the cutting edge of the puncture needle is housed in the tip.

  On the other hand, as a lancet drive device (drive mechanism) for displacing the lancet in the longitudinal direction, a device using a solenoid is known, such as a lancet drive device in an incision instrument described in Patent Document 2 and the like.

JP 2002-65644 A JP 2005-504564 A

However, in the puncturing means described in Patent Document 1 described above, the preparation for puncturing by the puncturing means and the preparation for sample collection are completed by manually compressing the puncture spring through the tip.
Therefore, it is necessary to manually compress the puncture spring before puncturing, and it takes time and labor to perform puncturing / measurement, and measurement with a one-touch operation is difficult.

Furthermore, by using a spring member for the puncture means, it is easy to ensure the puncture speed of the puncture needle, but the puncture operation cannot be accurately controlled, and the plunger and the puncture needle are damped after the puncture.
Therefore, measurement in a state where the blood is stationary is difficult, and accurate measurement by the measuring means is difficult.

Further, in order to measure a predetermined component in the blood collected from the specimen by the measuring means, a return operation for measuring such as removing the puncture needle and holding the tip position after puncturing is necessary. A plurality of spring members are required, such as a puncture spring and a pushback spring. In addition, a certain puncture distance is required to apply a predetermined acceleration or more to the puncture spring.
Therefore, the volume of the housing for housing the puncture spring and the pushback spring is increased, and the pump for reducing the pressure in the housing is also increased, so that the main body of the component measuring apparatus is increased in size.

In addition, even when a solenoid is used as the lancet driving device as in the incision instrument described in Patent Document 2, the lancet is used after puncture in order to measure a predetermined component in the blood collected from the specimen by the measuring means. Is required to be retracted by a predetermined amount, a plurality of solenoids are required. Further, in order to give the lancet a predetermined acceleration or higher, a certain size of solenoid is required.
Therefore, the stationary housing that accommodates the solenoid becomes larger, and the measuring device equipped with such a lancet driving device becomes larger.

  Accordingly, the present invention has been made in view of the above-described problems, and the structure of a drive mechanism for performing puncture by simultaneously driving a puncture device and a biosensor chip can be simplified and miniaturized, and puncture can be performed with one touch. Another object of the present invention is to provide an inexpensive and compact needle-integrated measuring apparatus capable of performing accurate measurement.

The object of the present invention includes a connector to which a biosensor cartridge integrally including a puncture tool and a biosensor chip is detachably mounted, and a drive mechanism for driving the connector to puncture the measurement apparatus main body. A needle integrated measuring device,
The drive mechanism is
A crank plate that is rotationally driven by a drive motor;
An eccentric shaft provided on the crank plate;
A crank rod connected to the eccentric shaft and reciprocatingly moving the connector at a speed corresponding to the rotational speed of the crank plate;
It is achieved by a needle-integrated measuring apparatus characterized by comprising:

According to the needle-integrated measuring apparatus having the above-described configuration, the drive mechanism is configured such that the biosensor cartridge is moved via the crank rod that is reciprocated at a speed corresponding to the rotational speed of the crank plate that is rotationally driven in one direction by the drive motor. The attached connector can be punctured.
Therefore, the structure of the drive mechanism is simplified, and the measurement apparatus main body can be reduced in size and cost. Further, the drive mechanism can reciprocate the biosensor cartridge without rotating the drive motor in the reverse direction, and the puncture operation can be accurately controlled.

Further, in the needle-integrated measuring apparatus having the above-described configuration, the needle-integrated measuring apparatus including a decompression mechanism that places a puncture site by the puncture device in a decompressed state together with a storage space that houses the biosensor cartridge,
It is desirable that the decompression mechanism applies a negative pressure in the accommodation space by moving a piston of a decompression pump connected to the eccentric shaft.

  According to the needle-integrated measuring apparatus having such a configuration, the decompression of the accommodation space and the puncture site and the puncture of the biosensor cartridge can be performed by the same driving operation. Therefore, measurement by one-touch operation is possible.

In the needle-integrated measuring apparatus having the above-described configuration, it is preferable that the pressure reduction amount in the housing space is adjusted by changing the pressure reduction stroke of the piston by changing the rotation start position of the crank plate.
According to the needle-integrated measuring apparatus having such a configuration, the amount of reduced pressure can be adjusted only by changing the movement start position of the movable member without changing the puncture speed.

In the needle-integrated measuring apparatus having the above-described configuration, it is preferable that the drive motor is a rotation position / speed control motor (for example, a stepping motor, a servo motor, an ultrasonic motor, or a synchronous motor) of the crank plate.
According to the needle-integrated puncture device having such a configuration, numerical control of puncture driving is possible, and setting / changing of the puncture speed, stroke, and the like are facilitated.

Further, in the needle-integrated measurement apparatus having the above-described configuration, a cylindrical case capable of airtightly sealing the housing space is detachable from the measurement apparatus main body by pressing a tip contact portion against the puncture site. As
It is desirable that the measurement apparatus main body is provided with a detection mechanism for detecting the mounting state of the cylindrical case.

According to the needle-integrated puncture device having such a configuration, it is easy to replace the contact portion that contacts the subject.
Therefore, for example, even if blood or the like adheres to the cylindrical case, it can be easily cleaned or replaced, and the needle-integrated puncture device can always be kept in good hygiene. In addition, by providing a detection mechanism in the measurement device body to detect the mounting state of the cylindrical case, the puncture depth varies due to the incomplete mounting state of the cylindrical case, or the cylindrical case is not mounted. Use and the like can be prevented.

According to the needle-integrated measurement apparatus according to the present invention, the structure of the drive mechanism is simplified, and the measurement apparatus main body can be reduced in size and cost. Further, the drive mechanism can reciprocate the biosensor cartridge without rotating the drive motor in the reverse direction, and the puncture operation can be accurately controlled.
Accordingly, it is possible to provide an inexpensive and compact needle-integrated measuring apparatus that can easily and miniaturize the structure of a driving mechanism for performing puncturing by simultaneously driving the puncture tool and the biosensor chip, and capable of performing accurate measurement. it can.

Hereinafter, preferred embodiments of a needle-integrated measuring apparatus according to the present invention will be described in detail with reference to the accompanying drawings.
It should be understood that the embodiments disclosed herein are illustrative in all respects and are not restrictive. The scope of the present invention is defined by the terms of the claims, rather than the meanings described below, and is intended to include any modifications within the scope and meaning equivalent to the terms of the claims.

  FIG. 1 is a configuration diagram of a needle integrated measuring apparatus according to an embodiment of the present invention, and FIG. 2A is a horizontal sectional view showing a state in which the needle integrated measuring apparatus shown in FIG. 2 (b) is a cross-sectional view taken along the line BB in FIG. 2 (a), and FIGS. 3 and 4 are horizontal cross-sectional views showing a state during puncturing of the needle-integrated measuring apparatus shown in FIG. FIG. 5A is a cross-sectional view showing an example of a biosensor chip, and FIG. 5B is an end view of the biosensor chip as viewed from the direction A in FIG. 5A.

  As shown in FIGS. 1 to 4, the needle-integrated measuring apparatus 1 according to the present embodiment includes a biosensor cartridge 11 integrally including a puncture needle 13 and a biosensor chip 20 as a puncture tool for puncturing a subject. The puncture site of the subject by the puncture needle 13 together with the connector 32 that is detachably attached, the drive mechanism 51 that drives the connector 32 to puncture the measurement apparatus main body 40, and the storage space 85 that accommodates the biosensor cartridge 11. And a measurement control device 30 that performs drive control of the drive mechanism 51 and the pressure reduction mechanism 41 and measurement by the biosensor chip 20.

  In this embodiment, examples of the puncture device include a hollow injection needle, a lancet needle, a cannula, and the like. These needles may be fixed to resin, or may be integrated with resin (the needle itself is also molded with resin). In the present embodiment, as an example of a puncture device, a lancet needle fixed to a resin is illustrated.

FIGS. 5A and 5B show an example of a biosensor chip 20 in which the puncture needle 13 is integrally provided.
The biosensor chip 20 includes a chip body 21 having two substrates 22a and 22b facing each other and a spacer layer 23 sandwiched between the two substrates 22a and 22b. 13 is fixed between the two substrates 22a and 22b.

Detection electrodes 24a and 24b are provided on the surface of at least one substrate 22a of the two substrates 22a and 22b on the spacer layer 23 side, and tips (lower ends in FIG. 5A) are mutually connected. It is bent in an L shape in the opposite direction to maintain a predetermined interval.
At the rear end 21b of the chip body 21, the substrate 22a extends beyond the substrate 22b and the spacer layer 23, and the detection electrodes 24a and 24b are exposed on the substrate 22a.

A hollow reaction portion 25 is formed by the two substrates 22a and 22b and the spacer layer 23 from the tip portion 21a of the chip body 21 to a portion where the two detection electrodes 24a and 24b are opposed to each other.
At the tip of the hollow reaction part 25, a sample collection port 25a for introducing blood as a sample collected by puncturing the specimen with the puncture needle 13 into the hollow reaction part 25 is provided. The sample collection port 25a is provided close to the puncture needle 13, so that even a small amount of sample can be reliably collected, and the burden on the user can be reduced.

In the hollow reaction part 25, the detection electrodes 24a and 24b are exposed, and for example, an enzyme and a mediator are immobilized and reacted with glucose in the blood immediately above or in the vicinity of the detection electrodes 24a and 24b in the hollow reaction part 25. A reagent 26 for generating an electric current is provided.
Accordingly, the hollow reaction part 25 is a part where blood such as blood collected from the sample collection port 25a undergoes a biochemical reaction with the reagent 26.

  As the material of the substrates 22a and 22b and the spacer layer 23, an insulating material film is selected. As the insulating material, ceramics, glass, paper, biodegradable material (for example, polylactic acid microorganism-producing polyester), poly Examples thereof include thermoplastic resins such as vinyl chloride, polypropylene, polystyrene, polycarbonate, acrylic resin, polybutylene terephthalate and polyethylene terephthalate (PET), thermosetting resins such as epoxy resins, and plastic materials such as UV curable resins. A plastic material such as polyethylene terephthalate is preferable because of its mechanical strength, flexibility, and ease of chip fabrication and processing. Representative PET resins include Melinex and Tetron (trade names, manufactured by Teijin DuPont Films, Inc.), Lumirror (trade names, manufactured by Toray Industries, Inc.), and the like.

  Examples of the reagent 26 include enzymes such as glucose oxidase (GOD), glycolose dehydrogenase (GDH), cholesterol oxidase and urigase, and electron acceptors such as potassium ferricyanide, ferrocene and benzoquinone. In consideration of the blood sampling burden of the specimen, the volume of the hollow reaction part 25 is preferably 1 μL (microliter) or less, and particularly preferably 300 nL (nanoliter) or less. With such a minute hollow reaction part 25, a sufficient blood volume of the specimen can be collected even if the diameter of the chip body 21 is small. The puncture needle 13 preferably has a diameter of 1000 μm or less.

  Further, as shown in FIG. 2, a substantially cylindrical elastic body 15 is provided at the distal end of the biosensor cartridge 11 so that the puncture needle 13 is inserted and the puncture needle 13 protrudes from the distal end surface during compression. . A concave portion 19 is formed on the distal end surface of the elastic body 15, and the concave portion 19 has a hemispherical bulging portion 18 formed at the center bottom. A through hole 16 that penetrates the elastic body 15 is formed in the center of the bulging portion 18, and the through hole 16 is formed larger than the outer diameter of the puncture needle 13 so that the puncture needle 13 of the chip body 21 is inserted. . The dimension of the elastic body 15 in the axial direction is a length that can reliably cover the tip of the puncture needle 13. That is, the puncture needle 13 is arranged inside the bulging portion 18.

  The elastic body 15 is deformed so that the peripheral wall portion 17 of the distal end surface is crushed by the compressive force in the axial direction. Further, when the same compressive force is applied, the bulging portion 18 is also deformed so as to be crushed to the vicinity of the bottom surface of the concave portion 19. That is, the puncture needle 13 is relatively projected from the distal end surface of the elastic body 15 by the action of the compressive force. This compressive force is applied by the drive mechanism 51.

  The material of the elastic body 15 is not particularly limited as long as it has elasticity. However, the elastic body 15 is made of a single polymer or a copolymerized polymer such as silicone, urethane, acrylic, ethylene, styrene, butadiene, acrylonitrile, propylene, and chloroprene. Rubber or sponge, polyethylene, polyolefin such as polypropylene, polyester such as polyethylene terephthalate and polybutylene terephthalate, polytetrafluoroethylene and fluororesin such as PFA which is a copolymer of perfluoroalkoxyethylene and polyfluoroethylene, etc. can be used .

The connector 32 has a rear end connected and fixed to one end of a connecting shaft 73 of the drive mechanism 51 to be described later. With the biosensor chip 20 attached, the connector 32 is moved forward (downward in FIG. 2) in the puncture direction. ). The connector 32 has a hermetically sealed structure, and no air leaks from the connector wiring or the like to the drive mechanism 51 side.
The rear end portion 21b of the chip body 21 is inserted and fixed at the distal end portion of the connector 32 that is disposed so as to be movable in the puncture direction with respect to the measuring apparatus body 40, and is electrically connected to the detection electrodes 24a and 24b. A terminal insertion portion 32a is provided.

  The terminal of the terminal insertion portion 32a is electrically connected to the control portion of the measurement control device 30 via the electric wire 77 wired in the connector wiring through hole 73a of the connecting shaft 73, and the detection of the biosensor chip 20 is performed. The reaction between the sample detected by the electrodes 24 a and 24 b and the reagent 26 is transmitted to the control unit of the measurement control device 30.

  As shown in FIGS. 2 to 4, the drive mechanism 51 of this embodiment includes a disc-shaped crank plate 59 that is rotationally driven by a drive motor 53, an eccentric shaft 54 provided on the crank plate 59, and an eccentric shaft 54. And a crank rod 55 that reciprocates the connector 32 at a speed corresponding to the rotational speed of the crank plate 59.

The drive motor 53 of this embodiment is a stepping motor that is a rotational position / speed control motor for the crank plate 59, and the rotational speed is controlled by a motor control unit in the measurement control device 30. A servo motor, an ultrasonic motor, a synchronous motor, or the like can also be used as a motor that can control the rotational position and speed of the crank plate.
The crank plate 59 is connected to the motor shaft of the drive motor 53, and an eccentric shaft 54 projects from an upper surface eccentric from the rotation center.

One end of a first crank rod (crank rod) 55 and one end of a second crank rod 56 are rotatably supported on the eccentric shaft 54.
A connecting shaft 73 is connected to the other end of the first crank rod 55 by a pivot pin 57. A piston 90 is connected to the other end of the second crank rod 56 by a pivot pin 52.

Therefore, when the crank plate 59 is rotationally driven in one direction (X direction in FIG. 1) by the drive motor 53, one end is pivotally supported by the eccentric shaft 54 via the first crank rod 55 and the pivot pin 57. The connecting shaft 73 can be reciprocated in the puncture direction.
That is, the connecting shaft 73 reciprocates along the axial direction at a speed corresponding to the rotational speed of the crank plate 59. The connecting shaft 73 is connected to the eccentric shaft 54 of the crank plate 59 through the first crank rod 55 rotatably supported by the eccentric shaft 54 and the pivot pin 57 at both ends. Even when the direction of movement is reversed by rotating approximately 180 degrees or more, it can be smoothly reversed.

  Therefore, the drive mechanism 51 connects the connector 32 to which the biosensor cartridge 11 is mounted via the connecting shaft 73 that is moved at a speed corresponding to the rotational speed of the crank plate 59 that is rotationally driven in one direction by the drive motor 53. Puncture drive is performed (see FIG. 3).

  Further, the drive mechanism 51 drives the connector 32 to move backward in the direction opposite to the puncture direction via a connecting shaft 73 that is moved at a speed corresponding to the rotational speed of the crank plate 59 that is rotationally driven in one direction by the drive motor 53. be able to.

  In the decompression mechanism 41 of the present embodiment, as shown in FIG. 2, the piston 90 connected at one end to the other end of the second crank rod 56 connected to the eccentric shaft 54 of the crank plate 59 slides in the cylinder 93. A pressure reducing pump 91, a cylindrical case 80 that is detachably attached to the opening of the cartridge mounting portion 83 of the measuring apparatus main body 40, and that defines a housing space 85 that houses the biosensor cartridge 11, and a sealed cylinder 93 The pressure communication path 97 which connects the decompression space 95 and the accommodation space 85 is provided.

The decompression pump 91 generates a negative pressure in the decompression space 95 when the piston 90 is moved in the puncture direction with respect to the cylinder 93.
The cylindrical case 80 can hermetically seal the accommodation space 85 by the tip contact portion 80a being pressed against the puncture site of the subject. The measuring device main body 40 is provided with a detection mechanism 81 for detecting the mounting state of the cylindrical case 80.

The pressure communication path 97 keeps both spaces at the same pressure by communicating the decompression space 95 and the accommodation space 85 with a tube or the like. An airtight seal 87 is provided between the connecting shaft 73 inserted into and removed from the housing space 85 and the cartridge mounting portion 83 to keep the inside of the housing space 85 airtight.
Therefore, the crank plate 59 can apply a negative pressure in the sealed housing space 85 by moving the piston 90 of the decompression pump 91 to the puncture phrase with respect to the cylinder 93 via the second crank rod 56. it can.

  Therefore, as shown in FIG. 3, the decompression mechanism 41 is connected to the decompression pump 91 via the crank plate 59 that is moved at a speed corresponding to the rotational speed of the crank plate 59 that is rotationally driven in one direction by the drive motor 53. When the piston 90 is moved to the puncture phrase with respect to the cylinder 93, the puncture site by the puncture needle 13 together with the accommodation space 85 can be in a reduced pressure state.

  The decompression mechanism 41 is configured such that the piston 90 of the decompression pump 91 is connected to the cylinder 93 via the second crank rod 56 that is moved at a speed corresponding to the rotational speed of the crank plate 59 that is rotationally driven in one direction by the drive motor 53. In contrast, the depressurized state of the storage space 85 can be released by being moved in the direction opposite to the puncture phrase (see FIG. 4).

Further, the decompression mechanism 41 of the present embodiment drives the drive motor 53 to bring the crank plate 59 to the origin before pressing the tip contact portion 80a of the cylindrical case 80 against the puncture site of the subject. By appropriately rotating from the position, the decompression stroke of the piston 90 can be changed to appropriately adjust the decompression amount in the accommodation space 85.
That is, by changing the rotation speed of the drive motor 53 in response to the change in the rotation range of the crank plate 59, the puncture speed of the biosensor cartridge 11 can be made constant, so that the crank plate can be changed without changing the puncture speed. The rotation start position 59 can be changed.

A switch 35 is provided on the surface of the measuring device main body 40. When the drive motor 53 is driven to rotate by the operation of the switch 35 and the rotation start position of the crank plate 59 is changed, the set decompression amount is set. Is displayed on the display unit 36.
The crank plate 59 can be returned to the origin position by a rotation sensor 99 for origin detection connected to the control unit of the measurement control device 30.

Next, the operation of the needle-integrated measuring apparatus 1 configured as described above will be described.
6A is a schematic cross-sectional view of a main part showing a state during puncturing of the needle integrated measuring device according to the present embodiment, and FIG. 6B is a state after puncturing of the needle integrated measuring device according to the present embodiment. It is a principal part schematic sectional drawing which shows these.

This needle-integrated measuring apparatus 1 is small in size, for example, a handy type that a user can hold with one hand, and can be operated by the user himself.
First, the cylindrical case 80 is removed from the cartridge mounting portion 83 of the measuring apparatus main body 40, and the biosensor chip 20 is inserted and attached to the terminal insertion portion 32 a of the connector 32. When the biosensor chip 20 is attached to the terminal insertion portion 32 a of the connector 32, the biosensor chip 20 is electrically connected to the control unit of the measurement control device 30 via the electric wire 77.

Then, the cylindrical case 80 is mounted on the cartridge mounting portion 83. At this time, the detection mechanism 81 detects the detection unit 80b of the cylindrical case 80, so that the needle-integrated measuring apparatus 1 can check the mounting state of the cylindrical case 80.
Initially, the crank plate 59 has returned to the origin position, and the eccentric shaft 54 is located at the top dead center position (position in FIG. 2) farthest from the biosensor chip 20, but the pressure is reduced by pressing the switch 35. By appropriately adjusting the amount, the crank plate 59 is appropriately rotated from the origin position, and the crank plate 59 is moved to the measurement start position.

And the front-end | tip contact part 80a of the cylindrical case 80 is pressed on the puncture site | part (for example, fingertip) of the subject M. FIG.
When the switch 33 is pressed in this state, the piston 90 of the decompression pump 91 is moved via the second crank rod 56 that is moved at a speed corresponding to the rotational speed of the crank plate 59 that is slowly rotated by the drive motor 53. The cylinder 93 is moved in the puncturing direction.

Therefore, since the decompression pump 91 generates a negative pressure in the decompression space 95, the storage space 85 communicated by the pressure communication path 97 is also decompressed, and a suction force acts on the puncture site of the subject M.
Next, when the crank plate 59 is rotated to the measurement start position and the depressurization operation is completed, the first crank is moved at a speed corresponding to the rotational speed of the crank plate 59 that is rapidly rotated by the drive motor 53. Via the rod 55 and the connecting shaft 73, the connector 32 to which the biosensor cartridge 11 is attached is driven to puncture.

  Then, the crank plate 59 rotates, the eccentric shaft 54 is rotated to the nearest bottom dead center position (position shown in FIG. 3) from the biosensor chip 20, and the tip of the biosensor cartridge 11 that has been punctured is pushed to a predetermined level. When pressed against the subject M with pressure, the peripheral wall portion 17 and the bulging portion 18 of the elastic body 15 are crushed and the puncture needle 13 is projected as shown in FIG. Thereby, the tip of the protruding puncture needle 13 is punctured into the subject M.

  Further, when the crank plate 59 is rotated, the eccentric shaft 54 is slightly rotated from the bottom dead center position, and the tip of the biosensor cartridge 11 driven to puncture is retracted by a predetermined amount, it is shown in FIG. Thus, the puncture needle 13 reaches the final movement measurement position (position in FIG. 4) extracted from the subject M and stops. At the same time, the elastic body 15 deformed by the pressing force returns to its original shape by the restoring force. At this time, the drive mechanism 51 can retract the biosensor cartridge 11 by a predetermined amount without rotating the drive motor 53 in the reverse direction.

When the puncture needle 13 is removed from the subject M, the blood B flowing out from the puncture hole is guided to the sample collection port 25a opened at the tip of the biosensor chip 20, and the sample collection port 25a leads to the hollow reaction unit 25. Inflow.
At this time, since negative pressure is applied in the accommodation space 85, negative pressure also acts on the blood B flowing out from the puncture hole, and the blood B is efficiently applied to the hollow reaction part 25 of the biosensor chip 20. Can be aspirated.

  Then, when the blood B flowing into the hollow reaction part 25 reacts with the reagent 26, an electric current is generated, and this electric current flows to the detection electrodes 24 a and 24 b of the substrate 22 a and is input to the measurement control device 30 through the electric wire 77. The Thereby, components in the blood are measured, and the measurement result is displayed on the display unit 36 by the control unit.

Thus, the biosensor cartridge 11 is mounted on the drive mechanism 51 via the connecting shaft 73 that is reciprocated at a speed corresponding to the rotational speed of the crank plate 59 that is rotationally driven in one direction by the drive motor 53. The connector 32 can be punctured.
Therefore, the structure of the drive mechanism 51 is simplified, and the measurement apparatus main body 40 can be reduced in size and cost. In addition, the drive mechanism 51 can reciprocate the biosensor cartridge 11 without rotating the drive motor 53 in reverse, thereby enabling accurate control of the puncturing operation. Furthermore, since the drive motor 53 is a stepping motor, numerical control of puncture driving is possible, and setting / changing of the puncture speed, stroke, and the like are easy.

In addition, the decompression mechanism 41 moves the piston 90 of the decompression pump 91 in the puncture direction via the second crank rod 56 connected to the eccentric shaft 54 of the crank plate 59, so that the inside of the accommodation space 85 of the biosensor cartridge 11. A negative pressure can be applied to.
Therefore, according to the needle-integrated measurement device 1 of the present embodiment, the pressure reduction with respect to the accommodation space 85 and the puncture site and the puncture with the biosensor cartridge 11 are the same drive operation, so that measurement with a one-touch operation is possible. Become. As a result, measurement can be performed in a short time and easily, and the burden on the user can be reduced.
Therefore, an inexpensive and compact needle-integrated measuring apparatus 1 that can easily and miniaturize the structure of the drive mechanism 51 for simultaneously performing the puncture by simultaneously driving the puncture needle 13 and the biosensor chip 11 and performing an accurate measurement. Can be provided.

  A puncture device, a biosensor chip, a biosensor cartridge, a connector, a measurement device main body, a drive mechanism, a crank plate, an eccentric shaft, a crank rod, a decompression mechanism, a decompression pump, a drive motor, and the like according to the needle integrated measurement device of the present invention The configuration of the cylindrical case or the like is not limited to the configuration of the above-described embodiment, and it goes without saying that appropriate modifications and improvements can be made based on the gist of the present invention.

It is a lineblock diagram of a needle integrated measuring device concerning one embodiment of the present invention. (A) is a horizontal sectional view which shows the state in the standby state of the puncture of the needle integrated type measuring apparatus shown in FIG. 1, and (b) is a BB sectional arrow view in (a). FIG. 2 is a horizontal sectional view showing a state during puncturing of the needle integrated measuring apparatus shown in FIG. 1. It is a horizontal sectional view which shows the state after the puncture of the needle integrated measuring apparatus shown in FIG. (A) is sectional drawing which shows an example of a biosensor chip, (b) is an end view of the biosensor chip seen from A direction in (a). (A) is a principal part schematic sectional drawing which shows the state during the puncture of the needle integrated measuring apparatus shown in FIG. 1, (b) shows the state after the puncture of the needle integrated measuring apparatus shown in FIG. It is a principal part schematic sectional drawing.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Needle integrated measuring device 11 ... Biosensor cartridge 13 ... Puncture needle (puncture tool)
DESCRIPTION OF SYMBOLS 15 ... Elastic body 20 ... Biosensor chip 30 ... Measurement control apparatus 32 ... Connector 40 ... Measurement apparatus main body 41 ... Depressurization mechanism 51 ... Drive mechanism 52, 57 ... Axis pin 53 ... Drive motor (Rotation position and speed control motor of crank plate) )
54 ... Eccentric shaft 55 ... First crank rod (crank rod)
56 ... Second crank rod 59 ... Crank plate 73 ... Connection shaft 80 ... Cylinder case 85 ... Accommodating space 90 ... Piston 91 ... Decompression pump 93 ... Cylinder 95 ... Decompression space 97 ... Pressure communication passage M ... Subject

Claims (5)

A needle-integrated measurement apparatus comprising: a connector to which a biosensor cartridge integrally including a puncture device and a biosensor chip is detachably mounted; and a drive mechanism for driving the connector to puncture the measurement apparatus main body. And
The drive mechanism is
A crank plate that is rotationally driven by a drive motor;
An eccentric shaft provided on the crank plate;
A crank rod connected to the eccentric shaft and reciprocatingly moving the connector at a speed corresponding to the rotational speed of the crank plate;
A needle-integrated measuring apparatus comprising: A needle-integrated measurement device provided with a decompression mechanism for bringing the puncture site by the puncture device into a decompressed state together with a housing space for housing the biosensor cartridge,
The needle-integrated measuring apparatus according to claim 1, wherein the pressure reducing mechanism applies a negative pressure to the housing space by moving a piston of a pressure reducing pump connected to the eccentric shaft.   The needle integrated measuring apparatus according to claim 2, wherein the pressure reduction amount in the accommodation space is adjusted by changing a pressure reduction stroke of the piston by changing a rotation start position of the crank plate.   The needle-integrated measuring apparatus according to any one of claims 1 to 3, wherein the drive motor is a rotation position / speed control motor of the crank plate. By pressing the tip contact portion against the puncture site, a cylindrical case capable of hermetically sealing the accommodation space is made detachable from the measurement apparatus main body,
5. The needle-integrated measuring apparatus according to claim 1, wherein the measuring apparatus main body is provided with a detection mechanism for detecting a mounting state of the cylindrical case.

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