JP2009096755A - Intravaginal cleaning agent and agent for treatment of vaginal infection disease - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an intravaginal cleaning agent effective for restoring self-cleaning action in the vagina by the affected person in the home, preventing the intrusion of bacteria, fungi, protozoa, etc., into the vagina, exterminating the intruded microorganisms, enabling easy handling and the self-treatment by the affected person, free from toxicity and exhibiting excellent effect. <P>SOLUTION: The intravaginal cleaning agent contains activated carbon as an active component. Powdery or granular activated carbon is dispersed in a liquid such as water, distilled water or an alcohol and applied to the vulva or the dispersion is impregnated into absorbent gauze, etc., and applied to the diseased part or impregnated into a cotton ball, a tampon, etc., and inserted into the vagina for a while to clean the vaginal wall. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

The present invention relates to a cleaning agent for washing the inside of the vagina affected by bacterial vaginosis, and further vaginal infections such as Chlamydia cervicitis, Trichomonas vaginitis, Candida vaginitis, and those vaginal infections, particularly bacterial vagina The present invention relates to a remedy for diseases and relates to medical and pharmaceutical technology.

  In the vagina of healthy adult women after menarche, for example, there are many bacteria of the genus Lactobacillus such as Bacillus dedelline, and the presence of these lactobacilli causes a normal bacterial balance in the vagina. It is maintained and genital infection by pathogenic microorganisms is prevented.

  This lactobacilli propagates by using glycogen secreted from the vaginal mucosa as an energy source and competes with pathogens from the back to protect the vaginal cavity from attack by other bacteria. With the development of a large number of antibiotics, as antibiotic preparations are frequently used, lactobacilli present in the vagina have been controlled.

  As a result, infected Bacteroides, Peptostreptococcus, Peptococcus, Mobilungs G. et al. Numerous anaerobic bacteria, including Vaginalis (Mobiluncus G. vaginalis), propagate in the vagina and their bacterial interaction causes bacterial vaginosis, and vaginal trichomonas (T. Vaginalis) or Vaginitis is manifested by infection with Candida; all the above mentioned Candida albicans.

  For treatment of these diseases, sulfonamides, antibiotics and antibacterial agents are mainly used. However, administration of these antibiotics is concerned about side effects such as rash, pruritus, local redness, irritation and erosion. In addition, Lactobacilli that are inherent in the vagina are also killed, and some pathogenic bacteria (for example, Staphylococcus) acquire resistance to antibiotics. It has become difficult to treat these diseases by substance administration.

  On the other hand, in Japanese Patent Application Laid-Open No. 11-322621 (Patent Document 1), it is presumed from the idea of supplementing a dead one in the treatment of vaginal infection. For example, Lactobacillus casei (Lactobacillus casei) , Lactobacillus gasseri, Lactobacillus fernsum, Lactobacillus casei pseudospatus, and Lactobacillus casei pseudospas Has proposed.

  However, the number of women suffering from bacterial vaginosis, Chlamydia cervicitis, Trichomonas vaginitis, Candida vaginitis has increased due to the abuse of antibiotics, as well as decreased immunity and active sexual behavior. Many women are reluctant to see a gynecologist due to these illnesses, and the number of cases is worsening.

  In order to improve such a situation, the inventor, based on the prior art, restores the self-cleaning action in the vagina in the home and prevents bacteria, fungi, protozoa, etc. from entering the vagina. Develop a cleansing agent that can sterilize the entry, is easy to handle, is not toxic, and is more effective, so that the affected person can self-treat, that is, make vaginal cleansing possible And made a proposal first.

The proposal is as disclosed in Japanese Patent Application Laid-Open No. 2004-67599 (Patent Document 2), and is said to have an effect of improving the state of intestinal microorganisms. The presumed substance (hereinafter referred to as lactic acid bacteria fermentation broth extract) is used as a cleaning agent in the vagina of women suffering from bacterial vaginosis, Chlamydia cervicitis, Trichomonas vaginitis, Candida vaginitis, etc. The lactic acid bacterium fermentation broth extract is excellent as an intravaginal cleaning agent, and is also effective as a therapeutic agent for those vaginal infections.
Japanese Patent Laid-Open No. 11-322621 Japanese Unexamined Patent Publication No. 2004-67599 (Claims)

  The inventor further relieves the above-mentioned problems, that is, the affected person recovers the self-cleaning action in the vagina in the home, prevents the invasion of bacteria, fungi, protozoa, etc. into the vagina, and sterilizes what has entered. We continued to investigate the challenges of developing a cleansing agent that is easy to handle, non-toxic, and effective, and that the affected person can self-treat and allow vaginal cleansing on their own.

As a result, the inventor also solved the above problems with activated carbon, which is also certified as a pharmaceutical for diarrhea, adsorption of product gas due to abnormal fermentation in the gastrointestinal tract, adsorption and detoxification in self poisoning / drug poisoning. It is excellent as a cleaning agent for the vagina of women suffering from bacterial vaginosis, chlamydia cervicitis, trichomonia vaginitis, Candida vaginitis, etc., and also effective as a treatment for those vaginal infections As a result, the present invention was completed.

That is, the invention according to claim 1 of the present invention is
An intravaginal cleaning agent characterized by comprising activated carbon as an active ingredient.

The invention according to claim 2 of the present invention is
It is a therapeutic agent for vaginal infection characterized by comprising activated carbon as an active ingredient.

The invention according to claim 3 of the present invention is
In the therapeutic agent for vaginal infection according to claim 2,
The vaginal infection is
It is characterized by bacterial vaginosis.

  By using the intravaginal cleaning agent of the present invention every day or every other day or every few days, the vagina is cleaned, bacterial vaginosis, chlamydial cervicitis, trichomonas vaginitis, Candida vagina Symptoms such as flame are alleviated or disappear.

  Activated charcoal has various effects due to its adsorption function. In this invention, the above-described effect of adsorbing bacteria, fungi, etc., and cleaning the inside of the vagina is also exhibited by this adsorption function. It is guessed. In fact, it is recognized that a large amount of adsorption is excellent in effect, but the mechanism of action of the effect exhibited by the present invention has not yet been clarified.

However, although the effect is inferior to that of the commercially available chromi vaginal preparation, it is superior to the lactic acid bacteria preparation, and when the improvement of clinical symptoms and recovery of acidity in the vagina are the end points of treatment, the vaginal cleanser of this invention Is a more protective and nurturing treatment method for resident Lactobacilli compared to treatment with vaginal chromia.

The intravaginal cleaning agent according to the present invention contains activated carbon as an active ingredient.
As the activated carbon, one that satisfies the regulations shown in the 10th revised Japanese Pharmacopoeia, which can be approved as medicinal charcoal, and that is made from a woody material such as coconut shell, which is usually used, has a diameter of 1 Those having fine pores of ˜20 nm are mentioned.
The activated carbon is not limited to the above-mentioned ones. For example, ion-exchange resins or similar polymer carbides (Japanese Patent Laid-Open No. 2006-256882) used as therapeutic agents for oral administration of renal liver diseases, Activated carbon such as a carbide of thermosetting resin (Japanese Patent Laid-Open No. 2006-328085) can also be applied to the present invention.

The intravaginal cleaning agent of the present invention contains activated carbon as an active ingredient and is powdery or granular, so that it is difficult to apply as it is.
Therefore, by dispersing it in a liquid such as water, distilled water, sterilized purified water or alcohol and applying it to the vulva, or soaking it in gauze, etc., and sticking it to the affected area, After immersing the dispersion in a cotton ball or tampon, the dispersion is inserted into the vagina for a while, and the vaginal wall can be cleaned by using a bidet or a syringe.

Activated carbon used in the present invention is approved as medicinal charcoal and has almost no side effects, i.e., a porous adsorption detoxifier, which has a property of adsorbing only a substance having a molecular weight within a specific range, It does not absorb the nutrients necessary for the body, but only adsorbs and excretes harmful substances.
Therefore, the application amount is not subject to severe restrictions and can be used freely.
Moreover, the intravaginal cleaning agent of the present invention may be used every day, every other day, or every few days, so that the inside of the vagina is cleaned and the symptoms of bacterial vaginosis are alleviated or disappeared. .
In Chlamydia cervicitis, Trichomonas vaginitis, Candida vaginitis, the symptoms are expected to be alleviated or eliminated.

Hereinafter, the intravaginal cleaning agent of the present invention will be described in more detail based on examples.
Example 1
<Preparation of cleaning agent>
Commercially available medicinal charcoal (super charcoal powder: manufactured by Kenpo Co., Ltd., cumulative pore area 2.39 ml / g, average pore radius 0.017 μm, total pore specific surface area 276 m ² / g) 5 cc distilled water 50 cc To obtain a vaginal cleanser.

<Cleaning effect confirmation test 1>
After obtaining informed consent to 5 outpatients aged 20 to 37 who have been complaining of increased vaginal discharge and bad odor, the vaginal cleansing agent obtained above is used as a cotton ball. 1.5 g was absorbed, inserted into the vagina, and then removed after 6 hours for intravaginal washing.
When performing vaginal lavage, collect vaginal discharge in the vagina, test for Chlamydia, Trichomonas, Candida, negative for Chlamydia, Trichomonas, Candida, vaginal discharge with yellow amine odor Some were clinically diagnosed with bacterial vaginosis.

The cleaning effect in each patient was as follows.
1) Patient 22 years old (OL)
The subamount increased for several weeks, and the partner pointed out vaginal odor. Chlamydia, Neisseria gonorrhoeae and Trichomonas were negative and met the diagnostic criteria for bacterial vaginosis.
The acidity in the vagina was pH: 7.8.
As a result of seven days of activated charcoal washing therapy for one week every day in the outpatient department, the subconscious amount decreased by 60%, malodor decreased by about 70%, and the pH decreased to 6.4.
There were no side effects, and contamination of the underwear with activated carbon was not a problem because it was washed away.

2) Patient 37 years old (housewife)
For several years, she suffered from bacterial vaginosis and has been treated repeatedly at 5 and 6 medical institutions such as university hospitals, public hospitals, and practitioners.
The main treatments were oral antibiotics, intravaginal treatment, and herbal medicines. Chlamydia, Neisseria gonorrhoeae and Trichomonas were negative.
As a result of performing the activated carbon cleaning therapy for 14 days, the subconscious amount decreased by 70%, malodor decreased by about 65%, and the pH decreased from 6.4 to 5.0.
No side effects were observed.

3) Patient 26 years old (engaged in customs industry)
A few months ago, she visited the hospital because of increased vaginal discharge.
Chlamydia, Neisseria gonorrhoeae, and Trichomonas were negative, and vaginal odor was positive when KOH was dropped on the secretions in the vagina, and the diagnosis was bacterial vaginosis.
During the course of the menstruation, the treatment was interrupted temporarily. However, as a result of performing activated charcoal washing therapy 10 times in the outpatient department, the subjective subordinate amount decreased by 68% and the bad odor decreased by about 90%.
No side effects were observed.

4) Patient 20 years old (student)
Several weeks ago, vaginal secretions increased abnormally, and mild vulvitis was accompanied by stimulation of the secretions.
Chlamydia, Neisseria gonorrhoeae, Trichomonas and Candida were negative, and the subjective vaginal odor was not strong, but the KOH test was positive, and bacterial vaginosis was diagnosed.
When activated charcoal washing therapy for 7 days was performed, the subconscious amount decreased by 58%, the odor decreased by approximately 80%, and the pH decreased from 6.8 to 6.4.
No side effects were observed.

5) Patient 28 years old (OL)
After a new partner was made two weeks ago, vaginal discharge increased and I began to feel a mild odor of the vagina.
Chlamydia, Neisseria gonorrhoeae, and Trichomonas tests were negative, and continuous activated carbon vaginal lavage therapy was continued for 7 days under the diagnosis of bacterial vaginosis.
Both the subconscious amount and odor decreased by about 90%, and the pH was improved from 6.4 to 5.0.
No side effects were observed.

<Cleaning effect confirmation test 2>
From outpatients,
1. Under the gray belt 2. Vaginal pH above 5 3. Detection of amine odor Detection of blue cells (more than 20% of epithelial cells)
Informed consent was obtained from 130 persons who were positive for 3 items, and the treatment was continued for 7 days as follows.
1) 33 patients: treatment with Kuromai vaginal tablets (manufactured by Sankyo Co., Ltd.) 2) 33 persons: washing treatment with lactic acid bacteria producing extract 3) 30 persons: treatment with lactic acid bacteria preparation (Biosley: manufactured by Toa Shinyaku Co., Ltd.) 4) 34 persons: Cleaning treatment with the intravaginal cleaning agent of the present invention The bad odor and the level of the belt were evaluated by the subject himself / herself in an outpatient using VAS (Visual Analog Scale).
The vaginal pH was measured at the first visit and at the end of treatment.
The results are shown in Table 1 (substantial change in subamount), Table 2 (substantial change in odor), and Table 3 (change in vaginal pH).

As a result, a therapeutic effect was observed in any of the four types, but a difference was observed in the degree of the effect, and in any case, the effect was lower in the lactic acid bacteria preparation.
Regarding the vaginal pH, the chromia vaginal agent was not statistically significant before and after the treatment, but the other treatment methods were significantly different.

  The intravaginal cleaning agent and vaginal infection therapeutic agent of this invention are particularly effective for bacterial vaginosis, and are expected to be effective for vaginal infections such as Chlamydia cervicitis, Trichomonas vaginitis, Candida vaginitis, As a cleaning agent for washing the vagina affected by these diseases and a therapeutic agent for these vaginal infections, it is widely used in medicine as a therapeutic agent because it has an effect comparable to conventional ones. In other words, it may be widely used in the pharmaceutical manufacturing field.

Claims (3)

An intravaginal cleaning agent characterized by comprising activated carbon as an active ingredient. A therapeutic agent for vaginal infection characterized by comprising activated carbon as an active ingredient. The vaginal infection is
The therapeutic agent for vaginal infection according to claim 2, which is bacterial vaginosis.