JP2009046399A - Dog body care system and dog body cleanser - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a dog body care system which can sufficiently care not only the hair of a dog but also the skin of a dog to improve dermatosis and the like and keep the skin in a good condition, and to provide a dog body cleanser using the same. <P>SOLUTION: The present invention relates to a dog body care system, characterized by coating the body skin of the dog with a liquid fatty oil having affinity with solid fat components accumulated on the skin to float stain substances containing the solid fat components, washing away the stain substances with a cleansing solution containing, as an active ingredient, a surfactant free from irritation to the skin and having a hydrophilic-lipophilic balance (HLB) in a range of 10 to 15, and, if necessary, then treating the skin with a humectant component, and to the dog body cleanser using the same. The liquid fatty oil having affinity with the solid fat components is preferably a liquid oil having a solubility parameter (SP value) in a range of 8.0 to 10.0. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a dog body care system and a dog body cleaning agent used therefor. More specifically, for dogs that have excellent dirt removal and cleaning action against dirt peculiar to dogs, mainly fat components that accumulate in the dog's body epidermis, and that have already suffered various damage to the skin The present invention also relates to a body care system for dogs that is mild to the skin and helps to recover skin damage, and a dog body cleaning agent used therefor.

  Due to the recent pet boom, dogs are bred for pets in many homes and raised like family members. Along with this, dermatitis such as atopy and various other skin injuries have become a major problem in dogs raised at home in this way.

  Dogs generally have their body covered with hair and, at the same time, secrete various fat components from their epidermis. For example, Shih Tzu and Cocca Spaniel are congenital dogs that tend to give out such fat in nature. If the fat component accumulated in the body epidermis is left unattended, it accumulates together with dust and mud from the surrounding environment, other various dirt substances, allergen substances, etc., and the fat component is oxidized here. Various bacteria are propagated, which often causes itching and skin diseases. Malassezia bacteria, staphylococci, etc. are present in the body epidermis of dogs as resident bacteria, and these often cause itching and skin diseases. In addition, itching and skin diseases are often caused by allergens such as house mites and house dust.

In the case of dogs, once itching or irritation occurs in the skin, it creates scratches by scratching the area vigorously, causing skin irritation, infections, and various other skins. Often causes injury.
In addition, even if the skin disease has not yet been reached, many dogs are in a damaged state, or the skin is very dry and is in the pre-stage state of skin disease. It often causes itching and other skin injuries.

  As methods for caring for the body of a pet dog, there are conventional so-called trimming stores that care for the hair and animal hospitals that treat skin diseases and the like. Trimming stores wash and cut body hair, and cleanse the body using various shampoos for the main purpose of removing dirt and odor from body hair. In veterinary hospitals, drug therapy using antibiotics or antibacterial agents, shampoo therapy to kill germs, and the like are generally performed for the purpose of treating pathological conditions of the skin.

  Trimming stores are designed to clean and care for body hair, so the body hair and epidermis are washed with detergents containing various surfactants. An agent or the like may be used, and as a result, the skin may be damaged. In particular, there are many cases where the skin is itchy or bruised, and it is almost in the state of skin disease, and the effect of damage to the skin due to trimming and washing is great.

  On the other hand, veterinary hospitals often use various drugs or treat skin with great irritation in order to treat the skin disease of dogs visiting as patients. For this reason, there are many treatments that are effective for the treatment of dermatoses, but are not necessarily preferable in terms of maintaining the skin in good condition. For example, for skin that has become a dry skin from atopy and becomes infected by bacteria, or from keratosis and seborrhea, use antibiotics or highly irritating medicated shampoos. It is common to treat infections. However, although such treatments can treat skin diseases such as infections, the skin itself is often rough, bruised and itchy, leaving the skin healthy and in good condition and maintaining it. This was not always satisfactory.

  The present invention has the above-mentioned problems related to the care of the body skin of dogs, that is, trimming emphasizes the care of body hair, and skin care is not sufficient, and animal hospitals emphasize the treatment of skin diseases. It solves the problem that the skin remains damaged due to the use of drugs, and not only the dog's body hair but also the dog's body epidermis is fully cared for. An object of the present invention is to provide a dog body care system capable of maintaining the skin in good condition and a dog body cleaning agent used therefor.

  The inventor of the present invention secretes and accumulates solid fat components in the dog's body epidermis, which mixes with surrounding dust and dirt, allergen substances and remains as dirt substances in the epidermis, where bacteria propagate. It has been found that the skin condition of the dog's body is remarkably improved by sufficiently removing the soiling substances containing such solid fat components, and it can be improved even when there is a skin disease such as atopy. Completed the invention.

That is, the present invention has the following contents.
(1) Applying liquid fats and oils that are compatible with solid fat components accumulated in the epidermis to the dog's body epidermis, causing the soiled material containing the solid fat components to rise, and then causing less irritation to the skin and being hydrophilic A body care system for dogs, which is washed away with a cleaning liquid containing a surfactant having an active / lipophilic balance (HLB) in the range of 10 to 15 as an active ingredient.
(2) The dog body care system according to (1), further comprising treating the dog's body skin after washing with a moisturizing component.
(3) The liquid oil having affinity for the solid oil component is a liquid oil having a solubility parameter (SP value) in the range of 8.0 to 10.0, (1) or (2) A dog body care system as described in.
(4) A group of liquid fats and oils having affinity for solid fats and oils components consisting of medium chain saturated fatty acid triglycerides having 6 to 12 carbon atoms, unsaturated fatty acid triglycerides having 14 to 18 carbon atoms, aliphatic liquid esters, or liquid vegetable oils The dog body care system according to any one of (1) to (3) above, which is any liquid oil selected from the group consisting of:
(5) The cleaning liquid for washing away the soil substance contains one or more surfactants selected from the group consisting of acylated amino acid surfactants or fatty acid amide surfactants as active ingredients, The dog body care system according to any one of (1) to (4).
(6) A first agent comprising a liquid oil composition containing, as an essential component, a liquid fat that is compatible with the solid fat component of the dog's epidermis, and a surfactant having a large detergency against the solid fat component and the liquid fat. A body washing agent for dogs comprising a second agent comprising a washing liquid containing an agent as an essential component.
(7) A first agent comprising a liquid oil composition containing, as an essential component, a liquid fat that is compatible with the solid fat component of the dog's epidermis, and a surfactant having a large detergency against the solid fat component and the liquid fat. A body washing agent for dogs comprising a second agent comprising a cleaning liquid containing an agent as an essential component and a third agent comprising a moisturizing component as an essential component.
(8) The above-mentioned (6) or (7), wherein the liquid fat having affinity for the solid fat component is a liquid fat having a solubility parameter (SP value) in the range of 8.0 to 10.0. The body cleaner for dogs described in 1.
(9) The surfactant having a large detergency with respect to the solid fat component and liquid fat is a surfactant having a hydrophilic / lipophilic balance (HLB) in the range of 10 to 15, (6) The body cleaning agent for dogs in any one of (8).

  The present inventors have a solid fat component secreted from the inside of the dog's body epidermis, which accumulates as a dirt substance in the epidermis together with dust, dirt, allergen substances, etc. from the surrounding environment. In addition, it was found that miscellaneous bacteria propagated in these accumulated solid fat components, causing atopy and various infectious diseases, and causing skin itchiness.

  And even if the dirt substance containing the solid fats and oils secreted from the inside of the body can be cleaned using a general cleaning agent for body washing of dogs, the dirt attached to the hair can be removed. The solid fat component accumulated on the skin surface deep in the body hair could not be removed satisfactorily. By applying the dog body care system of the present invention to such dirt on the dog's body epidermis, these solid fat components are lifted using liquid fats having affinity for the solid fat components. In addition, by using a cleaning liquid containing a surfactant having a large detergency to the solid fat component and liquid fat, the solid fat is washed with the liquid fat to which the soiled substance containing the solid oil component is lifted. The components could be removed sufficiently.

  And by applying such a dog's body care system of the present invention, the state of the dog's body epidermis that has been hardly considered in the conventional trimming of dogs and not sufficiently considered even in veterinary hospitals is extremely healthy. It was possible to improve the condition of the skin and to bring it into a good condition. By continuously applying the dog's body care system of the present invention, it becomes possible to continuously remove allergens and dirt from the dog's body epidermis, contributing to the construction of a barrier by moisturizing the skin. As a result, it is possible to improve the condition of damaged skin, improve atopy and dry skin, and treat various infectious diseases without using drug treatment or medicinal shampoo.

  The dog body care system of the present invention first applies these solid fats and oils to a soiled substance containing solid fat components accumulated in the dog's body epidermis by applying liquid fats and oils having affinity for the solid fat components. Dirty substances containing the components are lifted, and then the solid oil / fat containing the lifted solid oil / fat is used with a cleaning liquid containing a surfactant having a large emulsifying / dispersing power and detergency. It is characterized by being washed away with the liquid oil and fat coated with the substance. More preferably, the humectant component is applied to the body skin of the dog from which the dirt substance has been washed away.

  Solid fats and oils secreted from the dog's body and accumulated in the epidermis are lipids secreted from the sebaceous glands of the skin, specifically cholesterol and sterol esters, wax esters, neutral fats, etc. It consists of glycerol esters and various fatty acids.

  The dirt substance on the dog's body epidermis is mixed with these solid oils and fats, keratinocytes peeled off by the skin turnover, and house dust, dust and mud from the surrounding environment, and accumulates in the body epidermis. It is what.

  And the liquid fats and oils that have an affinity for these solid fat components that can be used in the present invention are liquids at room temperature. The solid fat component can be dissolved or dispersed. Specifically, such liquid oils and fats have a solubility parameter (SP value) difference of 2.0 or less, preferably 1.0 or less, with the above-described solid oil / fat components accumulated in the dog's epidermis. If it is.

Here, the solubility parameter is a material constant specific to each substance represented by the following formula, which depends only on temperature, and is a characteristic value of the substance that is a measure of the mixing property between liquids.
SP value = (E / V) ^1/2
(Here, E is the molecular cohesive energy of the liquid, and V is the volume of one molecule of the liquid.)

  Among the solid fat components accumulated in the dog's epidermis, sterol esters, wax esters, and glycerol esters have an SP value of about 9.0 to 9.6, so they are effectively used for these fat components. The liquid fats and oils that can be used in the present invention may have a solubility parameter (SP value) in the range of 8.0 to 10.0, and more preferably in the range of 8.5 to 9.6.

  Examples of such liquid oils include medium chain saturated fatty acid triglycerides such as caprylic acid triglyceride, capric acid triglyceride and lauric acid triglyceride, and oleic acid triglyceride and linoleic acid triglyceride. Glycerol esters such as unsaturated fatty acid triglycerides; liquid ester oils such as cetyl ethylhexanoate, cetyl octanoate, decyl octanoate, and hexyl laurate; liquid vegetable oils such as scallop oil, cottonseed oil, rapeseed oil, soybean oil, etc. Can be mentioned.

  In actual use, an optimal one may be selected from these liquid fats and oils according to the type of dog and the type of solid fat component. Generally, among these liquid oils and fats, caprylic acid triglyceride, capric acid triglyceride, hojo oil and the like are most preferable. Moreover, you may use not only one type of these liquid fats but 2 or more types in combination.

  Next, the solid oil / fat component of the dog's epidermis and the liquid oil / fat that has lifted it are washed away with a cleaning liquid containing a surfactant. The surfactant that can be used for the cleaning liquid of the body care system of the present invention has little irritation to the skin, and has a large emulsifying / dispersing power and cleaning power for such solid oil components and liquid oils. More specifically, those having a hydrophilic / lipophilic balance (HLB value) of 10 to 15 can be used, and those of 12 to 15 are more preferable. Furthermore, considering that it is often applied to damaged skin or dermatologic skin, a surfactant with as low irritation as possible is preferable. In that sense, a group of surfactants recognized as food additives is more preferred.

Examples of such surfactants include acylated amino acid surfactants such as cocoylglutamate triethanolamine and sodium lauroyl aspartate, and fatty acid amide surfactants such as palm fatty acid amide diethanolamide.
Of these, triethanolamine cocoyl glutamate and sodium lauroyl aspartate are highly foaming and safe anionic surfactants made from natural fatty acids and amino acids such as glutamic acid and aspartic acid. It has the same weak acidity and good skin feel, and is particularly preferable for the cleaning liquid of the care system of the present invention.

  The cleaning liquid used in the present invention may be an aqueous solution containing about 1.0 to 10.0%, preferably about 3.0 to 7.0% of these surfactants as active ingredients. Furthermore, a polyol such as sorbitol, 1,2-hexanediol or capryl glycol may be added and blended as a moisturizing component.

In the dog body care system of the present invention, after washing the whole body with hot water in advance and washing off mud stains and the like adhering to the hair, the above-described liquid oil is applied to the dog from 0.1 g to 10 cm ² of the body surface area. Apply in an amount of 10 g, preferably 0.5 g to 5 g. Specifically, a predetermined amount of liquid oil is applied so that it can reach the epidermis of the dog's body.
After leaving in this state for about several minutes, thoroughly foam the cleaning solution containing the above-mentioned surfactant, smear the foam over the entire body of the dog, scrub the hair roots manually, and solid fat component of the body epidermis Is lifted with liquid oil and fat to be removed. Next, this washing liquid component is sufficiently washed away with water or hot water. By applying the dog body care system of the present invention in this way, it is possible to reliably remove soil substances including solid fat components accumulated on the body surface, which are difficult to remove with ordinary shampoos.

  In the dog body care system of the present invention, a moisturizing agent composed of various moisturizing ingredients may be applied to the dog's body skin from which the soil material containing the solid fat component has been removed. The cleaned skin is a barrierless skin in which the dirt substance is removed and at the same time, the fat component beneficial to the skin is removed, and the barrier function of the skin is lowered. In order to prevent such irritation from the outside of the skin, it is particularly useful to provide such a moisturizing component.

Examples of these humectant components include various keratinocyte lipids such as ceramide 1, ceramide 3, ceramide 6II, and phytosphingosine; hyaluronic acid salts such as sodium hyaluronate and acid derivatives thereof; glycerin, hexanediol, capryl glycol, etc. These various polyols are mentioned.
Of these, ceramides and phytosphingosine are preferable because they have an excellent effect of keeping the skin moisturized and adjust the texture of the skin. Among them, ceramide 1, ceramide 3, and ceramide 6II are substances particularly required for damaged skin, and are more preferable for the care system of the present invention.

The present invention also includes a first liquid agent comprising a liquid oil composition containing a specific liquid oil having affinity for the above-described solid oil component as an active ingredient, and, if necessary, an emollient and the like. Containing a washing liquid that contains emulsifying / dispersing power, detergency, and low-irritant surfactants as active ingredients, and contains moisturizing ingredients as needed. It is a body washing agent for dogs used in a dog body care system composed of a second agent. Furthermore, the present invention provides a third humectant comprising, in addition to these first agent and second agent, various moisturizing components used as an essential component after using these first and second agents. It is a body washing agent for dogs used for a dog's body care system composed of the agent.
By applying the body care system of the present invention using this body washing agent for dogs of the present invention, it is possible to efficiently remove dirt substances on the epidermis containing solid fat components that accumulate in the body epidermis, which has hardly been conventionally considered. And can be reliably cleaned and removed.

  Specifically, the body washing agent for dogs of the present invention is liquid first at room temperature, and a liquid fat or oil having a solubility parameter (SP value) in the range of 8.0 to 10.0 as an essential component. And a second agent that contains a surfactant that has a low emulsification and dispersibility and a detergency for solid oil components and liquid oils, and has various moisturizing properties as required. It is comprised from the 3rd agent which consists of an ingredient. As the first agent, aliphatic liquid ester oils such as glycerol esters such as medium chain saturated fatty acid triglyceride and unsaturated fatty acid triglyceride described above, cetyl ethylhexanoate, cetyl octanoate, decyl octanoate and hexyl laurate, respectively. It consists of liquid vegetable oils such as hobako oil, cottonseed oil, rapeseed oil and soybean oil.

  The second agent is a surfactant having an HLB value in the range of 10 to 15, respectively. For example, acylated amino acid surfactants such as triethanolamine cocoyl glutamate and sodium lauroyl aspartate, Fatty acid amide surfactants such as palm fatty acid amide diethanolamide. The third moisturizing agent contains keratin intercellular lipids such as various ceramides, polyols such as glycerin and hexanediol, and the like as moisturizing components.

  The body of a dog is generally covered with hair, but it is densely covered with a large number of body hairs, and at the same time, depending on the dog breed, this hair is a multiple hair that extends from one hair root. . For this reason, it has been difficult to remove solid fats and oils accumulated in the body skin of dogs behind such body hair. Conventionally used dog shampoos were able to wash away dirt adhering to body hair, but it was difficult to wash solid oil and dirt adhering to the skin behind such hair. It was. On the other hand, by applying the body care system of the present invention using the body cleaning agent for a dog body care system of the present invention as described above, such a solid fat and oil and a soil containing the same are first introduced. The substance could be removed sufficiently.

  EXAMPLES Next, although an Example demonstrates this invention in more detail, this invention is not limited at all by these Examples. Further, “%” and “part” in the examples are based on mass unless otherwise noted.

Example 1:
To the eleven-year-old female Shih Tzu dog who has suffered from dog hair follicle infection due to hypothyroidism and systemic dermatitis and seborrhea for many years, the dog's body care system of the present invention using the dog body cleaner of the present invention Applied. The thyroid gland is treated with levothyroxine medication, and folliculosis is treated with doramectin injection at a veterinary hospital. Nonetheless, both had severe seborrhea, and although various shampoos had been used, it was considered impossible to recover because sebum that stuck to the skin could not be removed.
To this Shih Tzu dog, the body was washed with hot water of about 30 ° C. for the first week, and the dog's body care system of the present invention was applied twice a week in the first week and then once a week thereafter.
Specifically, first, the roots of the hair were carefully scrubbed for several tens of seconds in each direction in the direction opposite to the hair so that air and water were sufficiently mixed in the shower. Next, as a first agent, 30 ml of cleansing oil composed of a liquid oil composition having the composition shown in Table 1 below was sprinkled evenly on the dog's body, and the root of the hair was gently washed for about 5 minutes. Next, as a second agent, 30 ml of a shampoo composed of a cleaning liquid having the composition shown in Table 2 is diluted three-fold with water, placed in a frothing device, and fully foamed. After coating and thoroughly washing, it was left for about 3 minutes. Then, it rinsed thoroughly with about 30 degreeC hot water, and washed away the shampoo component completely. Further, the washing of the second agent with shampoo was repeated once more. Next, as a third agent, a moisturizing agent having the composition shown in Table 3 was used, and 30 ml of this was diluted about 10 times with water and applied to the entire body of the dog.

  The dog body care system of the present invention was continuously applied to the above Shih Tzu dog for one month at a frequency of once a week by the method described above. A photograph showing the skin condition of the Shih Tzu dog is shown in FIG. 1 before application of the dog body care system of the present invention, and in FIG. 2 after application of the dog body care system of the present invention. As can be seen from these photographs, after 1 month, the reddish part of the armpit disappeared considerably, and slight inflammation is observed, but the skin condition of this Shih Tzu dog has improved considerably overall, Hair growth was seen on the affected area of the face and tummy. In addition, secretions and bad odor disappeared completely.

Example 2:
The dog's body care system of the present invention was applied to a 9-year-old male Shih Tzu dog according to the present invention.
Repeated limb, axillary, and inner thigh dermatitis since childhood, diagnosed as atopic dermatitis and seborrhea, but all treatments by veterinarians were ineffective. After implementing the dog's body care system of the present invention by the same method as in Example 1 for 3 weeks, although it occasionally developed mild dermatitis, it recovered to normal skin.

Example 3:
The dog's body care system of the present invention using the dog body cleaner of the present invention was applied to a 6-year-old female Shih Tzu dog.
I was treated with a shampoo (medicinal sulfasalicylic acid shampoo: Fujita Pharmaceutical) and supplements twice a week at the direction of a veterinary hospital. It had been. After carrying out the dog's body care system of the present invention according to the same method as in Example 1 for 4 weeks, only slight inflammation remains, hair growth is observed in the lesion, secretion, malodor, dandruff Disappeared completely.

Example 4:
The dog's body care system of the present invention was applied to a 10-year-old castrated male Shih Tzu dog according to the present invention.
Dermatosis developed from 3 years and 6 months, and a large amount of dandruff and extremity dermatitis were the main symptoms in the early stage. Shampoo (medicinal norvasan shampoo) was prescribed at a veterinary hospital, but no improvement was seen. The skin disease gradually worsened, and after systemic seborrhea, treatment with a bactericidal medicinal shampoo (Maracebu shampoo) did not improve. After carrying out the dog's body care system of the present invention by the same method as in Example 1 for 3 weeks, only slight inflammation was occasionally observed, and the secretion and malodor disappeared completely.

Example 5:
The dog's body care system of the present invention was applied to a 9-year-old male American Cocker Spaniel according to the present invention.
The dog was unresponsive to all treatments at a veterinary hospital with dog hair follicle infection due to hypothyroidism and systemic dermatitis and seborrhea. After this dog was subjected to the dog's body care system of the present invention by the same method as in Example 1 for 3 weeks, hair growth was observed in the affected area, and secretions and malodor disappeared completely.

Example 6:
The dog's body care system of the present invention with the dog body cleaner of the present invention was applied to a contraceptive 7-year-old male miniature duck.
He developed allergic dermatitis around 5 years of age and multiple pattern alopecia. When this dog was subjected to the dog's body care system of the present invention by the same method as in Example 1 over 3 weeks, the symptoms of dermatitis were alleviated and hair growth was also observed.

Example 7:
The dog's body care system of the present invention was applied to a castrated 10 year old female cavalier with the dog body cleaner of the present invention.
All antibiotics prescribed by veterinarians and bactericidal detergents such as Norvasan shampoo were ineffective in deep pyoderma of unknown cause that began at the age of 9 years. When this dog was subjected to the dog's body care system of the present invention for 3 weeks in the same manner as in Example 1, pyoderma showed a tendency to improve, and occasionally had sporadic symptoms that were generally in good condition. I keep it.

  By applying the dog's body care system of the present invention, it is possible to effectively remove dirt substances including solid fat components accumulated in the dog's body epidermis, which has been difficult to cope with in conventional trimming stores and animal hospitals. Can relieve itching and itchiness of the skin and keep the skin in good condition. Therefore, it is useful as a body care system for pet dogs in place of conventional trimming stores and animal hospitals.

FIG. 1 is a photograph showing the skin condition of a dog before applying the method of the present invention in Example 1. FIG. 2 is a photograph showing the state of the dog's skin after applying the method of the present invention in Example 1.

Claims (9)

  Apply a liquid fat that is compatible with the solid fat component accumulated in the epidermis on the dog's body epidermis to lift up the soiling substance containing the solid fat component, and then it is less irritating to the skin. A dog body care system characterized by washing them with a cleaning solution containing a surfactant having an oily balance in the range of 10 to 15 as an active ingredient.   The dog body care system according to claim 1, further comprising treating the dog's body skin after washing with a moisturizing component.   The dog body care system according to claim 1 or 2, wherein the liquid fat having affinity for the solid fat component is a liquid oil having a solubility parameter value in the range of 8.0 to 10.0. .   The liquid fat having affinity for the solid fat component is selected from the group consisting of medium chain saturated fatty acid triglycerides having 6 to 12 carbon atoms, unsaturated fatty acid triglycerides having 14 to 18 carbon atoms, aliphatic liquid ester oils, or liquid vegetable oils. The dog body care system according to claim 1, wherein the dog body care system is any one of liquid oils.   The cleaning liquid for washing away the soil material contains one or more surfactants selected from the group consisting of acylated amino acid surfactants or fatty acid amide surfactants as active ingredients. The dog body care system according to any one of 4 above.   It is essential to have a first agent consisting of a liquid oil composition containing, as an essential component, a liquid fat that is compatible with the solid fat component of the dog's epidermis, and a surfactant having a large detergency against the solid fat component and the liquid fat. A body cleaning agent for dogs composed of a second agent comprising a cleaning liquid contained as a component.   It is essential to have a first agent consisting of a liquid oil composition containing, as an essential component, a liquid fat that is compatible with the solid fat component of the dog's epidermis, and a surfactant having a large detergency against the solid fat component and the liquid fat. A body washing agent for dogs composed of a second agent comprising a cleaning liquid contained as a component and a third agent comprising a moisturizing component as an essential component.   8. The body washing agent for dogs according to claim 6 or 7, wherein the liquid fat having affinity for the solid fat component is a liquid fat having a solubility parameter in the range of 8.0 to 10.0.   The surfactant having a large detergency with respect to the solid fat component or liquid fat is a surfactant having a hydrophilic / lipophilic balance in the range of 10 to 15. The body cleaning agent for dogs according to crab.