JP2009007379A5 - - Google Patents

Claims (16)

An oral administration agent comprising a drug-containing layer containing a drug to be administered, and a water-swellable gel-forming layer containing no drug and containing a water-swellable gel-forming agent,
The oral administration agent, wherein the water-swellable gel-forming layer is provided in the outermost layer of the oral administration agent.   The oral administration agent according to claim 1, wherein the oral administration agent is a film-form preparation.   The water-swellable gel-forming agent is at least one selected from carboxyvinyl polymer, starch and derivatives thereof, agar, alginic acid, arabinogalactan, galactomannan, dextran, pectin, gellan gum and xanthan gum. The oral administration agent according to claim 1 or 2.   The oral administration agent according to any one of 1 to 3, wherein the water-swellable gel-forming layer further contains a film-forming agent.   The oral administration agent according to claim 4, wherein the film forming agent is at least one selected from polyvinyl alcohol, polyvinyl pyrrolidone, hydroxyalkyl cellulose and alkyl cellulose.   The content of the water-swellable gel-forming agent in the water-swellable gel-forming layer is 15 to 70% by weight, and the content of the film-forming agent in the water-swellable gel-forming layer is 30 to 85% by weight. % Orally administered agent according to claim 4 or 5.   The oral administration agent according to any one of claims 1 to 6, wherein the water-swellable gel-forming layer can mask the taste and / or odor of the drug contained in the drug-containing layer. An oral administration agent having a drug-containing layer containing a plurality of layers of a drug to be administered, and a water-swellable gel-forming layer that does not contain the drug and contains a water-swellable gel-forming agent,
The drug-containing layers are heat-sealed via an intermediate layer containing an adhesive capable of heat-sealing, and the water-swellable gel-forming layer is provided in the outermost layer of the oral administration agent Orally administrated.   9. The oral administration agent according to claim 8, wherein the heat-bondable adhesive is a homopolymer of vinyl acetate or a copolymer of vinyl acetate and vinyl pyrrolidone.   The oral administration agent according to claim 8 or 9, wherein the oral administration agent is a film-form preparation.   The water-swellable gel-forming agent is at least one selected from carboxyvinyl polymer, starch and derivatives thereof, agar, alginic acid, arabinogalactan, galactomannan, dextran, pectin, gellan gum and xanthan gum. The oral administration agent in any one of Claims 8-10.   The oral administration agent according to any one of claims 8 to 11, wherein the water-swellable gel-forming layer further contains a film-forming agent.   The oral administration agent according to claim 12, wherein the film forming agent is at least one selected from polyvinyl alcohol, polyvinyl pyrrolidone, hydroxyalkyl cellulose and alkyl cellulose.   The content of the water-swellable gel-forming agent in the water-swellable gel-forming layer is 15 to 70% by weight, and the content of the film-forming agent in the water-swellable gel-forming layer is 30 to 85% by weight. The oral administration agent according to claim 12 or 13, wherein the oral administration agent is%.   The oral administration agent according to any one of claims 8 to 14, wherein the water-swellable gel-forming layer can mask the taste and / or smell of a drug contained in the drug-containing layer. An oral administration agent having a drug-containing layer containing a plurality of layers of a drug to be administered, and a water-swellable gel-forming layer that does not contain the drug and contains a water-swellable gel-forming agent,
  The oral administration agent, wherein the drug-containing layers are directly laminated, and the water-swellable gel-forming layer is provided in the outermost layer of the oral administration agent.