JP2009000177A - Packaging material for poultice, packing bag for poultice and its manufacturing method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a packing material for a poultice preventing the adhesion of the poultice at the time of packing and eliminating restriction at the time of bag making, and a packing bag for the poultice using it. <P>SOLUTION: The packing material 10 for the poultice is used for packing the poultice, which is obtained by laminating a sticking layer containing a medicine and a release sheet on the base material, and characterized in that release layers 13 comprising a release agent melted by heat at the time of heat sealing are regularly or irregularly and discontinuously formed on the heat-sealing layer 12 of a sheet 11 having the heat-sealing layer 12 at least on one side thereof at least at heat-sealing scheduled parts. The packing bag for the poultice is constituted by forming the packing material 10 into a bag-like shape. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a packaging material for packaging a patch having a patch layer, a packaging bag for storing the patch, and a method for producing the same.

  As a patch having a patch layer, for example, a drug-containing patch for administering a drug into a living body by percutaneous absorption can be gradually released into the living body over time by being applied locally. Are widely used in various fields. Such a drug-containing patch is made of a plastic layer such as polyester or polyethylene, or a patch layer containing a percutaneously absorbable drug on the surface of a base material such as a woven fabric or nonwoven fabric that has been subjected to a drug impermeable treatment. It is formed and a release sheet is laminated on the surface of the adhesive layer to protect the surface of the adhesive layer. Usually, such a patch is stored in a packaging bag made of a drug-impermeable sheet in order to prevent deterioration of the contained drug due to volatilization or environmental influence. When the patch is individually packaged in a packaging bag, the components of the patch layer containing the drug, for example, the patch layer composition itself, the plasticizer contained in the patch composition, the tackifier, etc. The adhesive sticks to the inner surface of the sheet constituting the packaging bag or the back surface of the base material and protrudes from the end surface, and it may be difficult to remove the patch from the packaging bag during use.

As a method for solving these problems, Patent Document 1 describes a bag whose inner surface is subjected to a low friction treatment, although it is not a packaging material for enclosing a patch. This bag is obtained by applying a low friction treatment to a silicone-based, fluorine-based, or long-chain alkyl-based treatment agent except for the entire inner surface or the periphery. And when low friction treatment is applied to the entire inner surface, a dot pattern fusion pattern is recommended, and the fluorine film is broken by biting in the dot pattern, and the film bases are bonded to each other and thermally fused. It is disclosed.
However, in this method, since the film base cannot be widely exposed, sufficient heat seal strength cannot be obtained. Further, basically, since the release agent layer is continuous in the seal portion, there is a high possibility that pinholes are generated, and it cannot be used as a packaging bag for storing patches.
Also in Patent Document 2, at least a part of the heat-sealing part of the packaging bag is configured by directly heat-sealing the heat-sealing resin layers of the sheet, and is peeled off to a part of the inner surface of the sheet. A packaging bag for storing a patch comprising an adhesion preventing layer made of an agent is described. FIG. 2A of Patent Document 1 shows a mode in which an adhesion preventing layer is formed in the entire area except the heat fusion area at the periphery of the sheet, and FIGS. 3 and 4 show an adhesion preventing layer area. A mode in which the heat-sealed region partially overlaps is shown.

However, in order to manufacture a packaging bag that has been subjected to a low friction treatment or an adhesion prevention treatment except for the periphery of these inner surfaces, use a packaging material in which an adhesion prevention layer region corresponding to the packaging bag is repeatedly formed. In such a packaging material, it is necessary to dispose the adhesion preventing layer region at a predetermined interval in advance corresponding to the size of the packaging bag, the width of the heat fusion region, and the like. For this reason, it is necessary for the packaging material provided with the adhesion preventing layer region to accurately manage the feed pitch when manufacturing the packaging bag. However, since a normal bag making machine or bag making filling and packaging machine controls feeding by a photoelectric tube or a CCD camera, it is necessary to color the adhesion preventing layer region. If the adhesion preventing layer region is colored, the colorant may enter the patch, and there may be a concern about the effect on the medicinal components and the human body. Even if the adhesion preventing layer region is colored, it becomes the inner surface of the packaging material. If the packaging material is not transparent, it may not be accurately detected by a phototube or a CCD camera. Usually, since the outer surface of the packaging material is printed, it is conceivable to print a control mark on the outer surface, but there is a problem that it is difficult to match the pitch between the inner surface printing and the outer surface printing with high accuracy. .
3-93444 JP 2005-328928 A

  The present invention has been made in view of the above circumstances, and can prevent adhesion when a patch is packaged, and can provide a high heat seal strength, and a patch without a pinhole using the same. It is an object of the present invention to provide an agent packaging bag and a method for producing the same.

In order to solve the above-mentioned problems, the present invention is a packaging material for packaging a patch comprising a base material and a release sheet laminated on a base material, wherein a heat seal layer is provided on at least one side. A release agent layer made of a release agent that melts with heat at the time of heat sealing is formed on the heat sealing layer of the sheet having a release agent layer that is regularly or irregularly interrupted at least at a predetermined heat seal portion. A patch packaging material is provided.
In the patch packaging material of the present invention, the release agent layer in the heat seal scheduled portion is formed by being intermittently formed in a dot-like, lattice-like, or stripe-like pattern in a plan view with respect to the sheet. Preferably it is.
It is preferable that the release agent layer does not contain a colorant.

Further, the present invention is a packaging bag for storing a patch formed by laminating a patch layer containing a drug and a release sheet on a substrate, and the release agent of the above-mentioned packaging material for patch packaging A patch packaging bag is provided in which a layer is disposed on the inner surface side to face each other, and the release agent is melted and heat-sealed.
In the patch packaging bag of the present invention, it is preferable that the release agent layer is dispersed in a sea-island state and heat-sealed at the seal portion.
The present invention also relates to a method of manufacturing a packaging bag for storing a patch comprising a base material and a release sheet laminated on a base material, the method comprising: Provided is a method for producing a packaging bag for a patch, characterized in that the release agent layer is disposed on the inner surface side and opposed to each other, and the release agent is melted and extruded to a region where heat sealing is not performed and heat sealed.

  According to the present invention, since a release agent layer (hereinafter, simply referred to as “release agent layer”) composed of a release agent that melts with heat during heat sealing is formed, the release agent is applied in an extremely small amount. Even if sufficient peeling performance is obtained. Therefore, in the part which is not heat-sealed, peeling performance is high and can prevent adhesion when the patch is packaged. And in the part to be heat-sealed, the release agent melted by the heat at the time of heat sealing is dispersed in the sea-island state by the pressure at the time of heat sealing and heat-sealed. Since the release agent layer is not continuous, the generation of pinholes in the seal portion can be prevented. In addition, when the release agent layer is provided regularly or irregularly on the entire surface, it is not necessary to control the feeding of the packaging material, so it is easy to make a bag without adding a colorant to the release agent layer. can do.

The present invention will be described below with reference to the drawings based on the best mode.
Fig.1 (a)-(e) is sectional drawing which shows the example of the packaging material for patches which concerns on this invention. FIG. 2 is a cross-sectional view showing an example of a patch packaging bag according to the present invention. FIG. 3 is a cross-sectional view taken along the line SS of FIG. FIG. 4 is a partial cross-sectional view showing the vicinity of the heat seal part of the patch packaging bag using the patch packaging material shown in FIG. 5A to 5D are plan views illustrating the pattern of the release agent layer in the patch packaging material according to the present invention.

  As shown in FIG. 1, the patch packaging material of this embodiment is a packaging material for packaging a patch formed by laminating a patch layer containing a drug and a release sheet on a base material, A release agent layer 13 is formed on the heat seal layer 12 of the sheet 11 having the heat seal layer 12 on one side. In the present invention, the release agent layer 13 is composed of a release agent that melts with heat during heat sealing. In the present specification, the release agent that melts by heat at the time of heat sealing is 40 ° C. or higher, more preferably 50 ° C. or higher, considering the case where the melting point is preferably exposed to a high temperature environment. It means a release agent that melts with heat during heat sealing. Examples of the release agent that melts with heat during heat sealing include wax release agents and alkyl pendant release agents that have a melting point equal to or lower than the melting point of the resin constituting the heat seal layer 12. As the low-melting point alkyl pendant release agent, for example, many as side chains such as Pyroyl (trade name) manufactured by Yushi Kogyo Co., Ltd. and Octadecyl isocyanate-modified polyethyleneimine (trade name: RP-20) manufactured by Nippon Shokubai Co., Ltd. And acrylic acid-based polymer compounds having a long-chain alkyl group. A group of polymer compounds having a long-chain alkyl group in the side chain is considered to exhibit a peeling effect due to the long-chain alkyl group. Accordingly, the carbon number of the long-chain alkyl group is 5 or more, preferably 12 or more, and the upper limit is not particularly limited, but the melting point tends to increase as the carbon number increases, and the solubility in the solvent deteriorates. Since it tends to be difficult and it may be difficult to form the release agent layer in a pattern, it is usually preferably 24 or less.

The release agent layer 13 is formed regularly or irregularly on the heat seal layer 12 of the packaging material in the heat seal planned portion. When formed in this way, it is possible to apply very little release agent. Usually, when an extremely small amount of release agent is applied, sufficient release performance cannot be obtained. However, the release performance of the release agent layer 13 can be maintained by forming the release agent intermittently. In the present invention, it can be provided intermittently and intermittently, but it is preferable to form it intermittently because it is easy to make the sealing strength uniform in heat sealing.
For example, in the patch packaging material 10 shown in FIG. 1A, the release agent layer 13 is repeatedly formed at a predetermined pitch over the entire surface of the packaging material. In order to use the packaging material 10 for a patch as a packaging bag for a patch, the area where the release agent layer 13 is repeatedly formed at a predetermined pitch on the outside is heat-sealed. Also, for the patch shown in FIG. In the packaging material 10 </ b> A, a part of the packaging material is used as a release agent layer forming region 14, and the release agent layer 13 is repeatedly formed at a predetermined pitch in the heat seal scheduled portion in the release agent layer forming region 14. In order to use the patch packaging material 10A as a patch packaging bag, the release agent layer forming region 14 is heat-sealed.
Further, in the patch packaging material 10B shown in FIG. 1 (c), a part of the packaging material is a release agent layer forming region 14, and the release agent layer 13 is formed solid in the release agent layer forming region 14. Yes. In order to use the patch packaging material 10B as a patch packaging bag, the heat seal layer 12 and the release agent layer 13 are heat-sealed on the outer side of the release agent layer forming region 14 and the outer side thereof. Intermittently in
Further, in the patch packaging material 10C shown in FIG. 1D, the release agent layer 13 is formed over the entire surface of the packaging material, but the region 15 in which the release agent layer 13 is repeatedly formed at a predetermined pitch. The inner side 16 is formed with a solid release agent layer 13. In order to use the patch packaging material 10C as a patch packaging bag, the region 15 where the release agent layer 13 is repeatedly formed is heat-sealed at a predetermined pitch.
Further, in the patch packaging material 10D shown in FIG. 1 (e), the release agent layer 13 is repeatedly formed at a predetermined pitch on the outer side 15 to be a heat seal planned portion, and the release agent layer 13 is solid on the inner side 16 thereof. The inner side 17 is not formed with the release agent layer 13. In order to use the patch packaging material 10D as a patch packaging bag, the region 15 where the release agent layer 13 is repeatedly formed at a predetermined pitch is heat-sealed.
In the case where the release agent layer forming region 14 is provided on the patch packaging material, the peripheral portion of the stored patch is the release agent layer forming region as shown in FIGS. 14 is preferably provided so as to contact 14.

  The release agent layer 13 can be formed by blending a release agent that melts with heat during heat sealing with an organic solvent or the like, and coating the sheet by a gravure method or other printing methods.

The release agent layer 13 is alternately adjacent (intermittently) with portions coated with a release agent that is melted by heat at the time of heat sealing (coated portion) and uncoated portions (non-coated portion). It is preferable to do. For example, as shown in FIG. 5, in a plan view with respect to the sheet 11, it is preferably formed in a dot-like pattern such as a polka dot or a square, a lattice pattern, or a stripe pattern. Among these, a dot-like shape is preferable because sufficient peeling performance can be obtained even if the release agent is applied in an extremely small amount, and it can be easily dispersed in the sea-island state by the pressure during heat sealing.
In the example shown in FIG. 5A, many release agent layers 13 are formed in a polka dot shape, and the heat seal layer 12 is exposed between the polka dot portions.
Moreover, in the example shown in FIG.5 (b), the releasing agent layer 13 is formed in square dot shape, the part between them is a non-coating part, and the heat seal layer 12 is exposed.
Further, in the example shown in FIG. 5C, the pattern of the release agent layer 13 is a lattice pattern, the release agent layer 13 is formed in the checkered portion, the lattice portion is an uncoated portion, and heat sealing is performed. Layer 12 is exposed.
Moreover, in the example shown in FIG.5 (d), the pattern of the releasing agent layer 13 is made into stripe form, between stripes is a non-coating part, and the heat seal layer 12 is exposed.

  The sheet 11 is preferably a gas-impermeable sheet from the viewpoint of suppressing the volatilization of the drug contained in the encapsulated patch, and this sheet is a single layer as long as it has a heat-fusible resin layer. Alternatively, it may have a laminated structure in which a plurality of layers are laminated. Typical examples of the gas-impermeable sheet include a vapor-deposited film obtained by vapor-depositing a metal foil such as aluminum, a metal oxide such as aluminum, and a metal oxide such as alumina and silica on a polyethylene terephthalate (PET) film. Some synthetic resin films have gas barrier properties even with a single layer by selecting the material and thickness. Specific examples of such a synthetic resin include vinylidene chloride, polyvinyl alcohol, ethylene-vinyl alcohol copolymer, and vinyl chloride. If the single-layer sheet itself is made of a heat-sealable material, the patch packaging material of the present invention can be configured by providing the above-described release agent layer on at least one surface of the single-layer sheet. Further, if the sheet itself is made of a material that cannot be heat sealed, a heat seal layer 12 is provided on at least one surface of the sheet 11 as shown in FIG.

  Polyolefins such as polyethylene and polypropylene may be used as the heat seal layer 12, but since there are many low-molecular compounds that easily volatilize, the drug used for the patch may be adsorbed to the heat seal layer. In such a case, a non-drug-adsorbing resin layer such as polyacrylonitrile (PAN), polyester, cyclic polyolefin, polyvinyl alcohol, or ethylene-vinyl alcohol copolymer is preferably laminated as the heat seal layer 12. The thickness of the heat seal layer 12 depends on the contents, but is usually about 10 to 150 μm. Further, for the purpose of improving printability and strength, paper or a biaxially stretched film may be laminated on the outermost layer. In this case, these materials may be gas permeable. The thickness of the packaging material can be selected according to the purpose, but generally, it is preferably about 10 to 150 μm for a single-layer sheet and 10 to 250 μm in total thickness for a laminated sheet.

In order to package a patch using the packaging material for patch of the present invention, the patch can be sealed by heat-sealing the periphery of the packaging material for patch packaging. When sealing, the packaging material may be molded into a bag shape in advance and sealed as a packaging bag, or bag making and filling may be performed simultaneously using a bag making filling and packaging machine.
To form the packaging bag of the present invention, a pair of sheets are placed facing each other, leaving an opening on one side, heat-sealing on three sides, and then enclosing the patch from the opening, then heating the opening What is necessary is just to seal and seal.

  The packaging bag for patches according to the present invention is a packaging bag for storing a patch formed by laminating a patch layer containing a drug and a release sheet on a base material, and the patch package according to the present invention The heat sealing layer and the release agent layer are arranged on the inner surface side and heat sealed. In heat sealing, a known heat sealer, impulse sealer, ultrasonic sealer, or the like can be used.

  FIG. 2 shows an example of the patch packaging bag 20. This packaging bag 20 is formed by heat-sealing the peripheral portions of a pair of packaging materials 10 arranged facing each other, and in the internal space 22 surrounded by the four heat-sealing portions 23, a patch 21 is provided. Can be stored. As shown in FIG. 3, the release agent layer 13 is provided on the inner surface of the packaging material 10 constituting the packaging bag 20 in the peripheral heat seal portion 23.

In FIG. 2, the pair of packaging materials 10, 10 arranged to face each other is composed of two sheet pieces, but it is not always necessary to fold two sheets, and one sheet is folded in two. In this case, if the airtightness can be ensured, the fold portion may be heat-sealed or not heat-sealed. In the heat seal portion 23, the heat seal layer 12 and the release agent layer 13 of one sheet piece and the heat seal layer 12 and the release agent layer 13 of the other sheet piece are heat sealed, thereby ensuring airtightness. Is done. Since the release agent layer 13 is melted by heat at the time of heat sealing, even if the release agent layer 13 is provided intermittently on the entire surface of the sheet piece, the release agent layer is dispersed in the sea-island state and is heat sealed. A sufficient seal strength can be obtained at the portion 23. The reason why the release agent layer is dispersed in the sea-island state and is heat-sealed depends on whether the release agent layer is formed regularly or irregularly at least in the heat-seal scheduled portion, Rather, sufficient peeling performance can be obtained by applying an extremely small amount of release agent and dispersing the release agent in a sea-island state with the pressure during heat sealing. And in order to obtain sufficient peeling performance, even if it is not possible to apply very little release agent, the release agent melted by the heat at the time of heat sealing is applied to the part that is not heat sealed by the pressure at the time of heat sealing. Ejected into a state with very little release agent, dispersed in a sea-island state and heat sealed. The exfoliated release agent is solidified inside the packaging bag and / or outside the packaging bag. Therefore, in heat sealing, it is preferable to heat-seal the inner side slightly from the outer peripheral end of the packaging bag. At this time, if a wire seal provided with a plurality of ridges or a mesh-shaped mold is used, or if heat sealing is performed with a woven fabric of fluorine-based fibers sandwiched, the melted release agent layer becomes a mesh, The heat seal layer 12 is easy to escape between the heat seal layers 12, and the release agent layer 13 has a portion where the release agent layers 13 are heat sealed, and high heat seal strength is obtained. Since it becomes difficult to continue, there is no occurrence of pinholes. However, even in this case, the heat seal portion is a portion where the release agent layer and the heat seal layer are heat sealed, a portion where the release agent layers are heat sealed, and a portion where the heat seal layers are heat sealed. Will be mixed. Note that the release agent layers melt and solidify, so that the release agent layers can be heat sealed. At this time, since the wax-based release agent has a low cohesive force, the seal strength is low. However, a certain degree of seal strength can be obtained with an alkyl pendant-type release agent having a low melting point. Further, since the release agent layer and the heat seal layer are in close contact with each other and melt and solidify, the seal strength is not so high, but can be heat sealed. Also, during heat sealing, the heat seal layer is also melted, so part of the release agent layer is embedded inside the heat seal layer, and the heat seal layer under the release agent layer is also considered to be involved in heat sealing. It is done.
3 and 4, since the release agent layer 13 is melted in the heat seal portion 23, the structure of the release agent layer 13 is formed in the heat seal portion 23 in the release agent layer forming region 14. Illustrated as having disappeared.

  By the way, in the present invention, the heat seal portion includes a portion where the release agent layer and the heat seal layer are heat sealed, a portion where the release agent layers are heat sealed, and a portion where the heat seal layers are heat sealed. Although there is a heat seal portion between the release agent layer and the heat seal layer that does not have high sealing strength, heat seal between the release agent layers with relatively high seal strength and between the heat seal layers with extremely high seal strength Since the portions are adjacent to each other, a high seal strength can be obtained as a whole. In addition, even if a location where the density of the heat seal portion between the release agent layer and the heat seal layer is high and the seal strength is reduced, the release agent layer is not continuous, and the release agent layer and the heat seal layer are heated. The heat seal part with the seal layer is firmly adhered even if the seal strength is not so high, so the release agent layers and the heat seal layers are pressed by the sheet of the heat sealed part and pinhole It will never be.

  The patch that can be applied to the present invention can be used without particular limitation as long as it has a patch layer. For example, it is possible to mention a patch obtained by laminating a patch layer containing a drug on a substrate and further laminating a release sheet on the patch layer to protect the surface of the patch layer.

  The base material of the patch is a polyolefin sheet such as polyethylene or polypropylene; a polyester sheet such as polyethylene terephthalate; a plastic sheet such as polyacrylonitrile; a stretchable elastomer or rubber sheet, a metal foil, and a non-chemical agent on the surface. A woven fabric, a nonwoven fabric, a composite sheet thereof, or the like that has been subjected to a permeation treatment can be used.

  The patch layer contains a known transdermally absorbable drug that can penetrate into the body through the skin as a medicinal component. Representative examples of the drug include blood circulation promoters such as l-menthol and camphor, analgesics such as indomethacin, and transdermal penetration enhancers such as urea, but are not limited thereto. The drug can be used alone or in combination of two or more according to the purpose of the patch.

  These agents are contained in an adhesive organic material mainly composed of a polymer such as an acrylic, rubber, silicone, or vinyl ether, and an adhesive layer using the organic material as a matrix is formed. A plasticizer, a tackifier, etc. can be mix | blended with the composition which forms this sticking layer as needed. Since the surface of the drug-containing patch layer formed on the substrate has adhesiveness, it is protected by laminating a release sheet until use.

  As the release sheet, a known release sheet can be arbitrarily selected and used, such as a resin film such as a PET film, a metal foil, paper, or a laminate of these films coated with silicone.

  The packaging material for patches and the patch packaging bag of the present invention have high hermeticity, can effectively prevent volatilization of the medicinal agent of the patch that is to be stored, and it is easy to take out the patch. For example, it can be suitably used for a patch containing a fragrance as a medicine.

(Manufacture of packaging materials for patches)
As a release agent that melts with heat at the time of heat sealing on a PAN surface of PET 12 μm / PAN 30 μm, it is a polymer compound that has a long-chain alkyl group with 18 carbon atoms and does not have an acrylic acid-based three-dimensional crosslinking. The company's Pyroyl HT (trade name) was coated by a gravure method with a dry weight of 0.3 g / m ^{2 in the} dot pattern of FIG. 5 (a) to produce a patch packaging material according to the present invention. As shown in Table 1, the dot diameter d, the flow direction pitch p1, and the width direction pitch p2 have three types of patterns as shown in Table 1. At this time, the thickness of the release agent layer is approximately 1.2 μm.

(Heat seal strength)
The heat seal strength of the packaging materials for patches of Examples 1 to 3 was measured according to JIS Z1707. The sealing conditions were heat sealing between the release agent-coated surfaces at a temperature of 160 ° C., a pressure of 0.2 MPa, a time of 1 second, and a heat sealer in which a woven fabric of polytetrafluoroethylene was attached to upper and lower molds. The tensile speed was 300 mm / min.

(Peel strength)
The peel strength of the packaging material for patches of Examples 1 to 3 was measured using cellophane adhesive tape (manufactured by Nichiban Co., Ltd., trade name “Cello Tape (registered trademark) No. 405”, 24 mm width) on the PAN surface (coating surface) of the packaging material. ) Was affixed using a roller, and the peel strength (integral average of peel strength between 15 and 50 mm from the start of peeling) when the T-shaped peel was performed at a peel speed of 50 mm was measured.

(Measurement result)
Table 2 shows the heat seal strength and peel strength (both average values of n = 5) measured at five points in the width direction of the packaging materials for patches of Examples 1 to 3. Further, Table 2 shows measured values of heat seal strength (heat seal between PAN surfaces) and peel strength of PET 12 μm / PAN 30 μm (no coating) as a conventional example.

  As shown in Table 2, the packaging material for patch of Examples shows sufficient heat seal strength comparable to that of the conventional example, and the adhesive has a lower peel strength than the conventional example. showed that. Note that this peel strength is for Cellotape (registered trademark), which has a much higher adhesive strength than the patch, so that when the patch is stored as a packaging bag using the patch packaging material of the example, The peel strength is such that it can be easily taken out even if the pressure sensitive adhesive sticks out and adheres to the release layer.

(A)-(e) is sectional drawing which shows the example of the packaging material for patches which concerns on this invention. It is sectional drawing which shows an example of the packaging bag for patches which concerns on this invention. It is sectional drawing which follows the SS line | wire of FIG. It is a fragmentary sectional view which shows the heat seal part vicinity of the packaging bag for patches using the packaging material for patches shown in FIG.1 (b). (A)-(d) is a top view which illustrates the pattern of the release agent layer in the packaging material for patches which concerns on this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10,10A, 10B, 10C, 10D ... Packaging material for patches, 11 ... sheet, 12 ... heat seal layer, 13 ... release agent layer composed of a release agent that melts by heat at the time of heat sealing, 14 ... formation of release agent layer Area 20, 20A ... packaging bag for patch, 21 ... patch, 22 ... storage space, 23 ... heat seal part.

Claims (6)

A packaging material for packaging a patch having a patch layer,
On the heat seal layer of the sheet having a heat seal layer on at least one side,
A patch packaging material, wherein a release agent layer composed of a release agent that melts by heat at the time of heat sealing is formed intermittently or irregularly at least at a predetermined heat sealing portion.   The said release agent layer in the heat-seal scheduled part is formed intermittently in a dot-like, lattice-like, or stripe-like pattern in a plan view with respect to the sheet. Packaging material for patches.   The patch packaging material according to claim 1 or 2, wherein the release agent layer does not contain a colorant. A packaging bag for storing a patch having a patch layer,
The patch packaging material according to any one of claims 1 to 3, wherein the release agent layer is disposed facing the inner surface side, and the release agent is melted and heat-sealed. Packaging bag.   The patch packaging bag according to claim 4, wherein the release agent layer is dispersed in a sea-island state and heat-sealed in the seal portion. A method of manufacturing a packaging bag for storing a patch having a patch layer,
The release agent layer of the packaging material for patch packaging according to any one of claims 1 to 3 is arranged on the inner surface side to face, and the release agent is melted and extruded to a region where heat sealing is not performed and heat sealed. A method for producing a packaging bag for patches.

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