JP2008538721A5 - - Google Patents
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- Publication number
- JP2008538721A5 JP2008538721A5 JP2008508768A JP2008508768A JP2008538721A5 JP 2008538721 A5 JP2008538721 A5 JP 2008538721A5 JP 2008508768 A JP2008508768 A JP 2008508768A JP 2008508768 A JP2008508768 A JP 2008508768A JP 2008538721 A5 JP2008538721 A5 JP 2008538721A5
- Authority
- JP
- Japan
- Prior art keywords
- calcium phosphate
- bone
- tcp
- scaffold
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- QORWJWZARLRLPR-UHFFFAOYSA-H Tricalcium phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 12
- 239000001506 calcium phosphate Substances 0.000 claims 12
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 8
- 235000011010 calcium phosphates Nutrition 0.000 claims 8
- 210000000988 Bone and Bones Anatomy 0.000 claims 5
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims 4
- 235000019731 tricalcium phosphate Nutrition 0.000 claims 4
- 229940078499 tricalcium phosphate Drugs 0.000 claims 4
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M Lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims 2
- 210000002805 Bone Matrix Anatomy 0.000 claims 1
- 230000002051 biphasic Effects 0.000 claims 1
- 239000004068 calcium phosphate ceramic Substances 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 239000004568 cement Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 230000002188 osteogenic Effects 0.000 claims 1
- 210000004663 osteoprogenitor cell Anatomy 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Inorganic materials [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims 1
- 235000013024 sodium fluoride Nutrition 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Claims (6)
- ８〜２４ mmol NaF/100g TCP及び／又は５〜４５ mmol LiCl/100g TCPを含む、吸収可能な二相性リン酸カルシウム（BCP)又はリン酸三カルシウム（TCP)。
- 骨（再）発生の足場の形態を有する、請求項１に記載のリン酸カルシウム。
- 該リン酸カルシウムがリン酸カルシウムのセラミック、セメント若しくは被覆、又はリン酸カルシウムを含有するガラス若しくは複合物の形態にある、請求項１又は２に記載のリン酸カルシウム。
- 該リン酸カルシウムが更に、１以上の骨成長因子、脱ミネラル化された骨マトリックス（ＤＢＭ）及び／又はミネラル化された骨粒子を含む、請求項１〜３のいずれか１項に記載のリン酸カルシウム。
- 請求項１〜４のいずれか１項に記載のリン酸カルシウムを含む、骨（再）発生の足場。
- 更に、幹細胞、骨原性細胞、及び／又は骨前駆細胞を含む、請求項５に記載の骨（再）発生の足場。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67422205P | 2005-04-25 | 2005-04-25 | |
| US60/674,222 | 2005-04-25 | ||
| EP05075973.7 | 2005-04-25 | ||
| EP05075973A EP1716873A1 (en) | 2005-04-25 | 2005-04-25 | Method of improving the osteoinductivity of bioactive materials |
| PCT/NL2006/000210 WO2006115398A1 (en) | 2005-04-25 | 2006-04-21 | Method of improving the osteoinductivity of calcium phosphate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008538721A JP2008538721A (ja) | 2008-11-06 |
| JP2008538721A5 true JP2008538721A5 (ja) | 2009-05-28 |
| JP4954198B2 JP4954198B2 (ja) | 2012-06-13 |
Family
ID=35170054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508768A Expired - Fee Related JP4954198B2 (ja) | 2005-04-25 | 2006-04-21 | リン酸カルシウムの骨誘導性を改善する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8460685B2 (ja) |
| EP (2) | EP1716873A1 (ja) |
| JP (1) | JP4954198B2 (ja) |
| AT (1) | ATE434451T1 (ja) |
| AU (1) | AU2006241047B2 (ja) |
| CA (1) | CA2606059A1 (ja) |
| WO (1) | WO2006115398A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2642830A1 (en) | 2006-02-17 | 2007-08-23 | Progentix Orthobiology B.V. | Osteoinductive calcium phosphates |
| GB0801935D0 (en) | 2008-02-01 | 2008-03-12 | Apatech Ltd | Porous biomaterial |
| US8337875B2 (en) | 2009-07-16 | 2012-12-25 | The Curators Of The University Of Missouri | Controlling vessel growth and directionality in mammals and implantable material |
| US8481066B2 (en) | 2009-07-16 | 2013-07-09 | The Curators Of The University Of Missouri | Scaffold for tissue regeneration in mammals |
| US8287896B2 (en) | 2010-01-06 | 2012-10-16 | The Curators Of The University Of Missouri | Scaffolds with trace element for tissue regeneration in mammals |
| US8173154B2 (en) | 2010-01-06 | 2012-05-08 | The Curators Of The University Of Missouri | Boron trioxide glass-based fibers and particles in dressings, sutures, surgical glue, and other wound care compositions |
| WO2012003438A1 (en) | 2010-07-02 | 2012-01-05 | Ada Foundation | Fluorapatite-forming calcium phosphate cements |
| US9272072B1 (en) | 2012-10-19 | 2016-03-01 | Nuvasive, Inc. | Osteoinductive bone graft substitute |
| EP3735204B1 (en) | 2018-01-02 | 2023-09-06 | Cartiheal (2009) Ltd. | Implantation tool for optimized solid substrates promoting cell and tissue growth |
| CN108969796A (zh) * | 2018-07-18 | 2018-12-11 | 余绍祥 | 一种携载rhBMP_2微球的新型可注射自凝固复合人工骨的制备方法 |
| US10786597B1 (en) | 2020-03-24 | 2020-09-29 | Secada Medical Llc | Methods of producing an osteoinductive calcium phosphate material for bone grafting |
| US11083557B1 (en) | 2020-05-01 | 2021-08-10 | Secada Medical Llc | Bone graft containment system |
| CN112773944A (zh) * | 2020-11-24 | 2021-05-11 | 季华实验室 | 一种具有微量元素负载涂层的骨修复支架及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534244A (en) * | 1989-05-24 | 1996-07-09 | Tung; Ming S. | Methods and compositions for mineralizing and/or fluoridating calcified tissues with amorphous strontium compounds |
| US5525148A (en) * | 1993-09-24 | 1996-06-11 | American Dental Association Health Foundation | Self-setting calcium phosphate cements and methods for preparing and using them |
| US6752831B2 (en) * | 2000-12-08 | 2004-06-22 | Osteotech, Inc. | Biocompatible osteogenic band for repair of spinal disorders |
| US7419680B2 (en) * | 2003-10-01 | 2008-09-02 | New York University | Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate |
-
2005
- 2005-04-25 EP EP05075973A patent/EP1716873A1/en not_active Withdrawn
-
2006
- 2006-04-21 US US11/919,390 patent/US8460685B2/en active Active
- 2006-04-21 EP EP06733017A patent/EP1877107B1/en not_active Not-in-force
- 2006-04-21 CA CA002606059A patent/CA2606059A1/en not_active Abandoned
- 2006-04-21 JP JP2008508768A patent/JP4954198B2/ja not_active Expired - Fee Related
- 2006-04-21 AT AT06733017T patent/ATE434451T1/de not_active IP Right Cessation
- 2006-04-21 AU AU2006241047A patent/AU2006241047B2/en not_active Ceased
- 2006-04-21 WO PCT/NL2006/000210 patent/WO2006115398A1/en active Application Filing
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