JP2008534650A - 新規置換ジアザビシクロ誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用 - Google Patents

新規置換ジアザビシクロ誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用 Download PDF

Info

Publication number
JP2008534650A
JP2008534650A JP2008504752A JP2008504752A JP2008534650A JP 2008534650 A JP2008534650 A JP 2008534650A JP 2008504752 A JP2008504752 A JP 2008504752A JP 2008504752 A JP2008504752 A JP 2008504752A JP 2008534650 A JP2008534650 A JP 2008534650A
Authority
JP
Japan
Prior art keywords
disorder
pain
diaza
bicyclo
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2008504752A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008534650A5 (enExample
Inventor
ペーターズ、ダン
ニールセン、エルセベット、オステルガード
レッドローブ、ジョン、ポール
Original Assignee
ノイロサーチ アクティーゼルスカブ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ノイロサーチ アクティーゼルスカブ filed Critical ノイロサーチ アクティーゼルスカブ
Publication of JP2008534650A publication Critical patent/JP2008534650A/ja
Publication of JP2008534650A5 publication Critical patent/JP2008534650A5/ja
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2008504752A 2005-04-04 2006-04-03 新規置換ジアザビシクロ誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用 Abandoned JP2008534650A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66766905P 2005-04-04 2005-04-04
DKPA200500466 2005-04-04
PCT/EP2006/061261 WO2006106090A1 (en) 2005-04-04 2006-04-03 Novel substituted diazabicyclo derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Publications (2)

Publication Number Publication Date
JP2008534650A true JP2008534650A (ja) 2008-08-28
JP2008534650A5 JP2008534650A5 (enExample) 2009-06-18

Family

ID=36588437

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008504752A Abandoned JP2008534650A (ja) 2005-04-04 2006-04-03 新規置換ジアザビシクロ誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用

Country Status (4)

Country Link
US (1) US7704991B2 (enExample)
EP (1) EP1869050A1 (enExample)
JP (1) JP2008534650A (enExample)
WO (1) WO2006106090A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008030988A2 (en) 2006-09-06 2008-03-13 The Regents Of The University Of California Selectively targeted antimicrobial peptides and the use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8422208D0 (en) * 1984-09-03 1984-10-10 Crosfield Electronics Ltd Colour printing data generation
TR199801641T2 (xx) * 1996-02-22 1998-11-23 Neurosearch A/S Tropan t�revleri bunlar�n haz�rlanmas� ve kullan�m�
TR200400510T4 (tr) 2000-08-03 2004-08-23 Pfizer Products Inc. Diazabisiklooktan türevleri ve bunların terapötik kullanımları

Also Published As

Publication number Publication date
US7704991B2 (en) 2010-04-27
WO2006106090A1 (en) 2006-10-12
EP1869050A1 (en) 2007-12-26
US20080280882A1 (en) 2008-11-13

Similar Documents

Publication Publication Date Title
JP5001156B2 (ja) 新規クロメン−2−オン誘導体及びモノアミン神経伝達物質再取込阻害剤としてのその使用
JP2010513392A (ja) 新規クロメン−2−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用
CN101405287B (zh) 色烯-2-酮衍生物和它们作为单胺神经递质再摄取抑制剂的用途
US7989470B2 (en) 3,8-substituted 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
EP1594868B1 (en) 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP2011511031A (ja) 新規な9−アザ−ビシクロ[3.3.1]ノン−3−イルオキシクロメン−2−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用
JP2006517567A (ja) 新規8−アザ−ビシクロ[3.2.1]オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
JP2010513391A (ja) 新規クロメン−2−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用
JP2009526023A (ja) 3,9−ジアザビシクロ[3.3.1]ノナン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのその使用
JP2011511030A (ja) 8−アザ−ビシクロ[3.2.1]オクタンの新規なフェニルエチニル誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用
JP2008534650A (ja) 新規置換ジアザビシクロ誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用
JP2008502650A (ja) 新規な9−アザ−ビシクロ[3.3.1]ノナン誘導体及びこれらのモノアミン神経伝達物質再取り込み阻害剤としての使用
EP1761512A1 (en) Novel alkyl substituted piperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP2008534653A (ja) 新規エナンチオマー及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用
US7923444B2 (en) Alkyl substituted homopiperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP2008546828A (ja) 新規な3−アザ−スピロ[5.5]ウンデカン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用
EP1937261B1 (en) Novel azabicyclo[3.2.1]oct-2-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US8093388B2 (en) 3-aza spiro[5,5]undec-8-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP2008546826A (ja) 新規な3,9−ジアザ−スピロ[5.5]ウンデカン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用
JP2010501624A (ja) 新規なピペリジン誘導体及びモノアミン神経伝達物質再取込み阻害剤としてのその使用
JP2009515850A (ja) モノアミン神経伝達物質再取り込み阻害薬としての8−アザ−ビシクロ[3.2.1]オクタン誘導体及びそれらの使用
HK1106514A (en) Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP2008524305A (ja) 新規なナフチル置換アザビシクロ誘導体、及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用
JP2008546827A (ja) 新規な3−アザ−スピロ[5.5]ウンデカ−8−エン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用
JP2008542431A (ja) 3−アリールオキシ−8−アザ−ビシクロ[3.2.1]オクタ−6−エン誘導体及びそれらのモノアミン神経伝達物質再取込阻害剤としての使用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090403

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090403

A762 Written abandonment of application

Free format text: JAPANESE INTERMEDIATE CODE: A762

Effective date: 20110224