JP2008534627A5 - - Google Patents

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JP2008534627A5
JP2008534627A5 JP2008504532A JP2008504532A JP2008534627A5 JP 2008534627 A5 JP2008534627 A5 JP 2008534627A5 JP 2008504532 A JP2008504532 A JP 2008504532A JP 2008504532 A JP2008504532 A JP 2008504532A JP 2008534627 A5 JP2008534627 A5 JP 2008534627A5
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amylin
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disorder
disease
agonist
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気分障害、不安障害または精神分裂病である精神の疾患または障害を治療するための配列番号:3、配列番号:33、配列番号:35、配列番号:67、配列番号:80、配列番号:81、配列番号:82および配列番号:83に記載の化合物よりなる群から選択されるアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体であって、
医薬が該疾患または障害を治療するために有効な量で投与され、アミリンアゴニストがカルシトニンではない該アミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体。
SEQ ID NO: 3, SEQ ID NO: 33, SEQ ID NO: 35, SEQ ID NO: 67, SEQ ID NO: 80, SEQ ID NO: 81 for treating mood disorders, anxiety disorders or mental disorders or disorders that are schizophrenia An amylin, amylin agonist, amylin analog or amylin derivative selected from the group consisting of the compounds set forth in SEQ ID NO: 82 and SEQ ID NO: 83,
The amylin, amylin agonist, amylin analog or amylin derivative, wherein a medicament is administered in an amount effective to treat the disease or disorder and the amylin agonist is not calcitonin.
該疾患または障害が不安障害である、請求項1記載の精神の疾患または障害の治療のためのアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体。   The amylin, amylin agonist, amylin analog or amylin derivative for the treatment of a psychiatric disease or disorder according to claim 1, wherein the disease or disorder is an anxiety disorder. 該不安障害が強迫障害である、請求項2記載の精神の疾患または障害の治療のためのアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体。   The amylin, amylin agonist, amylin analog or amylin derivative for the treatment of a mental disease or disorder according to claim 2, wherein the anxiety disorder is obsessive-compulsive disorder. 疾患または障害が鬱病である、請求項1記載の精神の疾患または障害の治療のためのアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体。   The amylin, amylin agonist, amylin analog or amylin derivative for the treatment of a psychiatric disease or disorder according to claim 1, wherein the disease or disorder is depression. 疾患または障害が精神分裂病である、請求項1記載の精神の疾患または障害の治療のためのアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体。   The amylin, amylin agonist, amylin analog or amylin derivative for the treatment of a psychiatric disease or disorder according to claim 1, wherein the disease or disorder is schizophrenia. 該化合物が、配列番号:4-31、36-66および86-253よりなる群から選択される請求項1〜5のいずれか1記載のアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体。   The amylin, amylin agonist, amylin analog or amylin derivative according to any one of claims 1 to 5, wherein the compound is selected from the group consisting of SEQ ID NOs: 4-31, 36-66 and 86-253. 請求項1〜5のいずれかのアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体を含む医薬上許容される組成物。   A pharmaceutically acceptable composition comprising the amylin, amylin agonist, amylin analog or amylin derivative of any one of claims 1-5. 該アミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体が、配列番号:4-31、36-66および86-253よりなる群から選択される請求項6記載の医薬上許容される組成物。   The pharmaceutically acceptable composition according to claim 6, wherein the amylin, amylin agonist, amylin analog or amylin derivative is selected from the group consisting of SEQ ID NOs: 4-31, 36-66 and 86-253. 気分障害、不安障害または精神分裂病である精神の疾患または障害を治療するための配列番号:3、配列番号:33、配列番号:35、配列番号:67、配列番号:80、配列番号:81、配列番号:82および配列番号:83に記載の化合物よりなる群から選択されるアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体を含む医薬組成物であって、
医薬が該疾患または障害を治療するために有効な量で投与され、アミリンアゴニストがカルシトニンではない該医薬組成物。
SEQ ID NO: 3, SEQ ID NO: 33, SEQ ID NO: 35, SEQ ID NO: 67, SEQ ID NO: 80, SEQ ID NO: 81 for treating mood disorders, anxiety disorders or mental disorders or disorders that are schizophrenia A pharmaceutical composition comprising amylin, amylin agonist, amylin analog or amylin derivative selected from the group consisting of the compounds of SEQ ID NO: 82 and SEQ ID NO: 83,
The pharmaceutical composition, wherein the medicament is administered in an amount effective to treat the disease or disorder and the amylin agonist is not calcitonin.
該疾患または障害が不安障害である請求項9記載の医薬組成物。   The pharmaceutical composition according to claim 9, wherein the disease or disorder is an anxiety disorder. 該不安障害が強迫障害である請求項10記載の医薬組成物。   The pharmaceutical composition according to claim 10, wherein the anxiety disorder is obsessive-compulsive disorder. 疾患または障害が鬱病である請求項9記載の医薬組成物。   The pharmaceutical composition according to claim 9, wherein the disease or disorder is depression. 疾患または障害が精神分裂病である請求項9記載の医薬組成物。   The pharmaceutical composition according to claim 9, wherein the disease or disorder is schizophrenia. 該アミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体が、配列番号:4-31、36-66および86-253よりなる群から選択される請求項9記載の医薬組成物。   The pharmaceutical composition according to claim 9, wherein the amylin, amylin agonist, amylin analog or amylin derivative is selected from the group consisting of SEQ ID NOs: 4-31, 36-66 and 86-253. 気分障害、不安障害または精神分裂病である精神の疾患または障害の治療用医薬の製造のための配列番号:3、配列番号:33、配列番号:35、配列番号:67、配列番号:80、配列番号:81、配列番号:82および配列番号:83に記載の化合物よりなる群から選択されるアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体の使用であって、
医薬が該疾患または障害を治療するために有効な量で投与され、アミリンアゴニストがカルシトニンではないことを特徴とする該使用。
SEQ ID NO: 3, SEQ ID NO: 33, SEQ ID NO: 35, SEQ ID NO: 67, SEQ ID NO: 80, for the manufacture of a medicament for the treatment of mood disorders, anxiety disorders or psychiatric diseases or disorders that are schizophrenia Use of an amylin, amylin agonist, amylin analog or amylin derivative selected from the group consisting of the compounds set forth in SEQ ID NO: 81, SEQ ID NO: 82 and SEQ ID NO: 83,
The use wherein the medicament is administered in an amount effective to treat the disease or disorder and the amylin agonist is not calcitonin.
疾患または障害が不安障害であることを特徴とする請求項15記載の使用。   16. Use according to claim 15, characterized in that the disease or disorder is an anxiety disorder. 不安障害が強迫障害であることを特徴とする請求項16記載の使用。   Use according to claim 16, characterized in that the anxiety disorder is obsessive compulsive disorder. 疾患または障害が鬱病であることを特徴とする請求項15記載の使用。   16. Use according to claim 15, characterized in that the disease or disorder is depression. 疾患または障害が精神分裂病であることを特徴とする請求項15記載の使用。   16. Use according to claim 15, characterized in that the disease or disorder is schizophrenia. 少なくとも1つの他の精神医薬が対象に投与されることを特徴とする請求項15記載の使用。   16. Use according to claim 15, characterized in that at least one other psychiatric drug is administered to the subject. 精神障害を治療用医薬の製造のための配列番号:3、配列番号:33、配列番号:35、配列番号:67、配列番号:80、配列番号:81、配列番号:82および配列番号:83に記載の化合物よりなる群から選択されるアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体の使用であって、
医薬が該障害を治療するために有効な量で投与され、物質関連障害が、物質依存、物質嗜癖、物質誘導不安障害および物質誘導気分障害よりなる群から選択される該使用。
SEQ ID NO: 3, SEQ ID NO: 33, SEQ ID NO: 35, SEQ ID NO: 67, SEQ ID NO: 80, SEQ ID NO: 81, SEQ ID NO: 82 and SEQ ID NO: 83 for the manufacture of a medicament for treating psychiatric disorders Use of an amylin, amylin agonist, amylin analog or amylin derivative selected from the group consisting of the compounds described in
The use wherein the medicament is administered in an amount effective to treat the disorder and the substance related disorder is selected from the group consisting of substance dependence, substance addiction, substance induced anxiety disorder and substance induced mood disorder.
物質関連障害が、物質嗜癖、物質誘導不安障害または物質誘導気分障害であることを特徴とする請求項21記載の使用。   Use according to claim 21, characterized in that the substance-related disorder is substance addiction, substance-induced anxiety disorder or substance-induced mood disorder. 少なくとも1つの他の精神医薬が対象に投与されることを特徴とする請求項22記載の使用。   23. Use according to claim 22, wherein at least one other psychiatric medication is administered to the subject. 該アミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体が、配列番号:4-31、36-66および86-253よりなる群から選択されることを特徴とする請求項15〜23のいずれか1記載の使用。   24. The amylin, amylin agonist, amylin analog or amylin derivative is selected from the group consisting of SEQ ID NOs: 4-31, 36-66 and 86-253. use.
JP2008504532A 2005-03-31 2006-03-31 Amylin and amylin agonists for the treatment of psychiatric disorders and disorders Expired - Fee Related JP5114381B2 (en)

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US66733505P 2005-03-31 2005-03-31
US66668105P 2005-03-31 2005-03-31
US60/667,335 2005-03-31
US60/666,681 2005-03-31
US67544105P 2005-04-28 2005-04-28
US60/675,441 2005-04-28
US76058306P 2006-01-20 2006-01-20
US60/760,583 2006-01-20
PCT/US2006/012601 WO2006105527A2 (en) 2005-03-31 2006-03-31 Amylin and amylin agonists for treating psychiatric diseases and disorders

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