JP2008534453A5 - - Google Patents

Info

Publication number

JP2008534453A5

JP2008534453A5 JP2008502282A JP2008502282A JP2008534453A5 JP 2008534453 A5 JP2008534453 A5 JP 2008534453A5 JP 2008502282 A JP2008502282 A JP 2008502282A JP 2008502282 A JP2008502282 A JP 2008502282A JP 2008534453 A5 JP2008534453 A5 JP 2008534453A5

Authority

JP

Japan

Prior art keywords

hydrates

formula

compound

salts

solvates

Prior art date

2006-03-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001875 compounds Chemical class 0.000 claims 11
• 150000004677 hydrates Chemical class 0.000 claims 9
• 238000000034 method Methods 0.000 claims 9
• 150000003839 salts Chemical class 0.000 claims 8
• 239000012453 solvate Substances 0.000 claims 7
• 206010063837 Reperfusion injury Diseases 0.000 claims 6
• -1 salt hydrates Chemical class 0.000 claims 5
• 125000004076 pyridyl group Chemical group 0.000 claims 4
• 125000000335 thiazolyl group Chemical group 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 3
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
• 239000000654 additive Substances 0.000 claims 2
• 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 2
• 229910052739 hydrogen Inorganic materials 0.000 claims 2
• 239000001257 hydrogen Substances 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 239000002552 dosage form Substances 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1