JP2008534017A - 癌の診断および治療のためのｄｋｋｌ−１のスプライス産物の調節因子 - Google Patents

癌の診断および治療のためのｄｋｋｌ−１のスプライス産物の調節因子 Download PDF

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JP2008534017A
JP2008534017A JP2008504393A JP2008504393A JP2008534017A JP 2008534017 A JP2008534017 A JP 2008534017A JP 2008504393 A JP2008504393 A JP 2008504393A JP 2008504393 A JP2008504393 A JP 2008504393A JP 2008534017 A JP2008534017 A JP 2008534017A
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Prior art keywords
dkkl
cancer
antibody
splice product
isoform
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JP2008504393A
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Japanese (ja)
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JP2008534017A5 (enExample
Inventor
アルバート レイ，
ロバート ブーハー，
Original Assignee
ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド
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Publication of JP2008534017A publication Critical patent/JP2008534017A/ja
Publication of JP2008534017A5 publication Critical patent/JP2008534017A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2008504393A 2005-03-30 2006-03-30 癌の診断および治療のためのｄｋｋｌ−１のスプライス産物の調節因子 Pending JP2008534017A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66643105P 2005-03-30 2005-03-30
PCT/US2006/011761 WO2006105343A2 (en) 2005-03-30 2006-03-30 Dkkl-i splice product modulators for cancer diagnosis and therapy

Publications (2)

Publication Number Publication Date
JP2008534017A true JP2008534017A (ja) 2008-08-28
JP2008534017A5 JP2008534017A5 (enExample) 2009-03-19

Family

ID=36950360

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008504393A Pending JP2008534017A (ja) 2005-03-30 2006-03-30 癌の診断および治療のためのｄｋｋｌ−１のスプライス産物の調節因子

Country Status (4)

Country Link
US (1) US8252267B2 (enExample)
EP (1) EP1896495A2 (enExample)
JP (1) JP2008534017A (enExample)
WO (1) WO2006105343A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2414460T3 (es) 2004-08-04 2013-07-19 Amgen Inc. Anticuerpos para Dkk-1
EP3488019B1 (en) 2016-07-21 2025-02-12 The General Hospital Corporation Extracellular mrna markers of muscular dystrophies in human urine
AU2018210316A1 (en) * 2017-01-17 2019-06-27 Illumina, Inc. Oncogenic splice variant determination

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005033343A2 (en) * 2003-09-30 2005-04-14 Chiron Corporation Novel splice variants of human dkkl1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736120A (en) * 1996-06-07 1998-04-07 Srinivasan; Ananthachari Method for preparing radiolabeled peptides
US7057017B2 (en) * 1997-04-16 2006-06-06 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
AU758004B2 (en) * 1997-12-17 2003-03-13 Genset S.A. Extended cDNAs for secreted proteins
CA2331154A1 (en) 1998-06-16 1999-12-23 Human Genome Sciences, Inc. Polypeptides having sequence identity with acid labile subunit of insulin-like growth factor
CA2366062C (en) * 1999-03-05 2014-06-17 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
JP2006507793A (ja) 2001-12-05 2006-03-09 キュラジェン コーポレイション 治療ポリペプチド、それをコードする核酸、および使用方法
AU2003248933A1 (en) 2002-07-11 2004-02-02 Incyte Corporation Secreted proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005033343A2 (en) * 2003-09-30 2005-04-14 Chiron Corporation Novel splice variants of human dkkl1
JP2007508020A (ja) * 2003-09-30 2007-04-05 カイロン コーポレイション ヒトｄｋｋｌ１の新規スプライス改変体

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN6010022668; Ｇｅｎｅ，　ｖｏｌ．　２３８，　ｐａｇｅｓ　３０１-３１３　（１９９９） *
JPN6010022669; Ｊ．　Ｂｉｏｃｈｅｍ．　Ｍｏｌ．　Ｂｉｏｌ．　Ｂｉｏｐｈｙｓ．，　ｖｏｌ．　５，　ｐａｇｅｓ　５４１-５４４　（２００１） *
JPN6010022670; Ｏｎｃｏｇｅｎｅ，　ｖｏｌ．　１９，　ｐａｇｅｓ　１８４３-１８４８　（２０００） *
JPN6010022671; Ｏｎｃｏｇｅｎｅ，　ｖｏｌ．　２１，　ｐａｇｅｓ　８７８-８８９　（２００２） *
JPN6011046481; 程久美子編: ＲＮＡｉ実験なるほどＱ＆Ａ ｐ．５２-５３, 20061001, 羊土社 *

Also Published As

Publication number Publication date
US20090155276A1 (en) 2009-06-18
WO2006105343A2 (en) 2006-10-05
WO2006105343A3 (en) 2007-07-12
US8252267B2 (en) 2012-08-28
EP1896495A2 (en) 2008-03-12

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