JP2008525493A5 - - Google Patents

Info

Publication number

JP2008525493A5

JP2008525493A5 JP2007548565A JP2007548565A JP2008525493A5 JP 2008525493 A5 JP2008525493 A5 JP 2008525493A5 JP 2007548565 A JP2007548565 A JP 2007548565A JP 2007548565 A JP2007548565 A JP 2007548565A JP 2008525493 A5 JP2008525493 A5 JP 2008525493A5

Authority

JP

Japan

Prior art keywords

composition

tumor

cancer

granulocyte

compound

Prior art date

2005-12-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 21
• 206010028980 Neoplasm Diseases 0.000 claims 14
• 210000003714 granulocyte Anatomy 0.000 claims 13
• LGZKGOGODCLQHG-UHFFFAOYSA-N combretastatin Natural products C1=C(O)C(OC)=CC=C1CC(O)C1=CC(OC)=C(OC)C(OC)=C1 LGZKGOGODCLQHG-UHFFFAOYSA-N 0.000 claims 12
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 12
• 238000000034 method Methods 0.000 claims 11
• 239000002246 antineoplastic agent Substances 0.000 claims 10
• -1 combretastatin compound Chemical class 0.000 claims 10
• 239000002168 alkylating agent Substances 0.000 claims 9
• 229940100198 alkylating agent Drugs 0.000 claims 9
• 239000012472 biological sample Substances 0.000 claims 7
• 229940123237 Taxane Drugs 0.000 claims 6
• 201000011510 cancer Diseases 0.000 claims 6
• 150000001875 compounds Chemical class 0.000 claims 6
• 229910052697 platinum Inorganic materials 0.000 claims 6
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 6
• 229930012538 Paclitaxel Natural products 0.000 claims 4
• 230000000259 anti-tumor effect Effects 0.000 claims 4
• 239000003080 antimitotic agent Substances 0.000 claims 4
• VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 4
• 229960004562 carboplatin Drugs 0.000 claims 4
• 229960001592 paclitaxel Drugs 0.000 claims 4
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
• 229940121849 Mitotic inhibitor Drugs 0.000 claims 3
• 229940041181 antineoplastic drug Drugs 0.000 claims 3
• 239000002552 dosage form Substances 0.000 claims 3
• 208000020816 lung neoplasm Diseases 0.000 claims 3
• LGZKGOGODCLQHG-CYBMUJFWSA-N 5-[(2r)-2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-2-methoxyphenol Chemical compound C1=C(O)C(OC)=CC=C1C[C@@H](O)C1=CC(OC)=C(OC)C(OC)=C1 LGZKGOGODCLQHG-CYBMUJFWSA-N 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• 208000013452 Fallopian tube neoplasm Diseases 0.000 claims 2
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 229960005527 combretastatin A-4 phosphate Drugs 0.000 claims 2
• WDOGQTQEKVLZIJ-WAYWQWQTSA-N combretastatin a-4 phosphate Chemical compound C1=C(OP(O)(O)=O)C(OC)=CC=C1\C=C/C1=CC(OC)=C(OC)C(OC)=C1 WDOGQTQEKVLZIJ-WAYWQWQTSA-N 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• 208000037841 lung tumor Diseases 0.000 claims 2
• 230000011278 mitosis Effects 0.000 claims 2
• 210000000440 neutrophil Anatomy 0.000 claims 2
• 239000000651 prodrug Substances 0.000 claims 2
• 229940002612 prodrug Drugs 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• NRKFVEPAQNCYNJ-YGGCHVFLSA-J tetrasodium;[3-methoxy-2-phosphonatooxy-6-[(z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P(=O)([O-])OC1=C(OP([O-])([O-])=O)C(OC)=CC=C1\C=C/C1=CC(OC)=C(OC)C(OC)=C1 NRKFVEPAQNCYNJ-YGGCHVFLSA-J 0.000 claims 2
• 206010008342 Cervix carcinoma Diseases 0.000 claims 1
• 201000001342 Fallopian tube cancer Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
• 206010061309 Neoplasm progression Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
• 230000017531 blood circulation Effects 0.000 claims 1
• 201000010881 cervical cancer Diseases 0.000 claims 1
• 229960004316 cisplatin Drugs 0.000 claims 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
• 229960003668 docetaxel Drugs 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 238000012544 monitoring process Methods 0.000 claims 1
• 229960001756 oxaliplatin Drugs 0.000 claims 1
• DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
• 210000004303 peritoneum Anatomy 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 208000026087 primary peritoneal tumor Diseases 0.000 claims 1
• 238000004393 prognosis Methods 0.000 claims 1
• 230000036962 time dependent Effects 0.000 claims 1
• 230000005751 tumor progression Effects 0.000 claims 1
• 208000024719 uterine cervix neoplasm Diseases 0.000 claims 1