JP2008518598A - 薬剤の毒性評価 - Google Patents

薬剤の毒性評価 Download PDF

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Publication number
JP2008518598A
JP2008518598A JP2007539186A JP2007539186A JP2008518598A JP 2008518598 A JP2008518598 A JP 2008518598A JP 2007539186 A JP2007539186 A JP 2007539186A JP 2007539186 A JP2007539186 A JP 2007539186A JP 2008518598 A JP2008518598 A JP 2008518598A
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protein
gene
biomarker
compound
genotoxic
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Japanese (ja)
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JP2008518598A5 (enExample
Inventor
ダニエル・バウアー
ペーター・グラス
クラウディア・マッギニス
フランク・シュテートラー
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ノバルティス アクチエンゲゼルシャフト
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Publication of JP2008518598A publication Critical patent/JP2008518598A/ja
Publication of JP2008518598A5 publication Critical patent/JP2008518598A5/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2007539186A 2004-10-29 2005-10-27 薬剤の毒性評価 Pending JP2008518598A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62362804P 2004-10-29 2004-10-29
PCT/US2005/039005 WO2006050124A2 (en) 2004-10-29 2005-10-27 Evaluation of the toxicity of pharmaceutical agents

Publications (2)

Publication Number Publication Date
JP2008518598A true JP2008518598A (ja) 2008-06-05
JP2008518598A5 JP2008518598A5 (enExample) 2008-10-30

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ID=36319674

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007539186A Pending JP2008518598A (ja) 2004-10-29 2005-10-27 薬剤の毒性評価

Country Status (4)

Country Link
US (1) US20080096770A1 (enExample)
EP (1) EP1807539A2 (enExample)
JP (1) JP2008518598A (enExample)
WO (1) WO2006050124A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013508835A (ja) * 2009-10-21 2013-03-07 ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー バイオマーカー参照パターンを作成する方法
JPWO2018124293A1 (ja) * 2016-12-28 2019-12-12 国立研究開発法人医薬基盤・健康・栄養研究所 トランスクリプトームによる医薬成分の特徴分析法および分類
JP2020025471A (ja) * 2018-08-09 2020-02-20 国立研究開発法人産業技術総合研究所 毒性学習装置、毒性学習方法、学習済みモデル、毒性予測装置およびプログラム
WO2020067464A1 (ja) * 2018-09-28 2020-04-02 学校法人東北工業大学 標的の特性の予測を行うための方法、コンピュータシステム、プログラム
WO2024202434A1 (ja) * 2023-03-31 2024-10-03 富士フイルム株式会社 情報処理装置、情報処理方法、及びプログラム

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101903774A (zh) * 2007-12-20 2010-12-01 弗·哈夫曼-拉罗切有限公司 预测基因毒性
US20090181415A1 (en) * 2007-12-20 2009-07-16 Hans Marcus Ludwig Bitter Prediction of genotoxicity
EP2281904A1 (en) * 2009-07-28 2011-02-09 Universiteit Maastricht In vitro method for predicting whether a compound is genotoxic in vivo.
KR101134029B1 (ko) * 2009-11-16 2012-04-13 한국과학기술연구원 인체 독성 유발 약물 탐색용 마커유전자 및 이를 이용한 탐색 방법
GB0921712D0 (en) 2009-12-11 2010-01-27 Ge Healthcare Uk Ltd Methods of detecting DNA damage
EP2639314A1 (en) * 2012-03-14 2013-09-18 Universiteit Maastricht In vitro method for predicting whether a compound is genotoxic in vivo.
DK3149204T3 (en) 2014-05-28 2021-10-25 Predictomics Ab In vitro toxicogenomics for toxicity prediction
EP3191591A1 (en) * 2014-09-12 2017-07-19 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting complement component c5 and methods of use thereof
WO2021256837A1 (ko) * 2020-06-15 2021-12-23 인제대학교 산학협력단 신장 질환 진단 또는 치료용 조성물
CN111812167A (zh) * 2020-07-15 2020-10-23 哈尔滨工业大学（深圳） 一种化学品间接毒性检测平台及其应用

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013508835A (ja) * 2009-10-21 2013-03-07 ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー バイオマーカー参照パターンを作成する方法
JP2016048570A (ja) * 2009-10-21 2016-04-07 ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー バイオマーカー参照パターンを作成する方法
JPWO2018124293A1 (ja) * 2016-12-28 2019-12-12 国立研究開発法人医薬基盤・健康・栄養研究所 トランスクリプトームによる医薬成分の特徴分析法および分類
JP2020025471A (ja) * 2018-08-09 2020-02-20 国立研究開発法人産業技術総合研究所 毒性学習装置、毒性学習方法、学習済みモデル、毒性予測装置およびプログラム
WO2020067464A1 (ja) * 2018-09-28 2020-04-02 学校法人東北工業大学 標的の特性の予測を行うための方法、コンピュータシステム、プログラム
JP2020051968A (ja) * 2018-09-28 2020-04-02 学校法人東北工業大学 標的の特性の予測を行うための方法、コンピュータシステム、プログラム
WO2024202434A1 (ja) * 2023-03-31 2024-10-03 富士フイルム株式会社 情報処理装置、情報処理方法、及びプログラム

Also Published As

Publication number Publication date
WO2006050124A3 (en) 2007-02-01
US20080096770A1 (en) 2008-04-24
WO2006050124A2 (en) 2006-05-11
EP1807539A2 (en) 2007-07-18

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