JP2008517037A - Synergistic mixture comprising 1,2-hexanediol and 1,2-octanediol and further a preservative - Google Patents

Abstract

  Disclosed is an antibacterial mixture which includes (a) 1,2-hexanediol and 1,2-octanediol and also any 1,2-pentanediol and / or 1,2-decanediol, and also (b ) Comprising or consisting of one, two or more substances selected from the group consisting of potassium sorbate, parabens and iodopropynyl butyl carbamate (IPBC).

Description

  The present invention relates to antimicrobial active substances, and in particular some mixtures, formulations and foodstuffs, and also comprising at least two unbranched (linear) 1,2-alkanediols and further preservatives It relates to a product comprising such a mixture in an anti-microbially effective amount.

Not only to store perishable products (e.g. cosmetics, pharmaceutical products or foodstuffs) in the cosmetic and pharmaceutical industry, and also in the food industry, especially when no drugs with anti-microbial properties are used, For fast cosmetic or therapeutic treatment of microorganisms that may have a detrimental effect on the human body or on the body of animals, cease to the drug with the anti-microbial properties There is a constant demand. As an example, attention can be paid to microorganisms that may cause body odor, acne, mycosis, and the like.
A number of antibacterial actives are used in the technical fields already under consideration and are alternatives to allow selective treatment and / or reduce side effects. Research on products continues without interruption. However, in research on antibacterial and in particular preservative alternatives, it is important to note that substances used in the cosmetic, pharmaceutical and / or foodstuff fields must have the properties listed below. Should be kept in:

• be toxicologically harmless;
・ High compatibility with skin;
Be stable (especially in known cosmetic and / or pharmaceutical formulations);
It is mainly and preferably totally odorless and can also be manufactured cheaply (ie using standard methods and / or starting from standard precursors).
There is no clear link between the chemical structure of a substance on the one hand and its biological activity on the other hand in relation to some microorganisms (bacteria) and its stability Due to the fact, it has been difficult for those skilled in the art to search for suitable (active) substances having, to a sufficient extent, one or more of the above properties. Furthermore, there is no predictable link between the anti-microbial effects, toxicological harmlessness, compatibility with the skin and stability of a substance.

According to a first aspect, the present invention provides (a) 1,2-hexanediol and 1,2-octanediol and also any 1,2-pentanediol and / or 1,2-decanediol, and also (b) comprises, or consists of one, two or more substances selected from the group consisting of potassium sorbate, parabens and iodopropynylbutylcarbamate (IPBC; 3-iodo-2-propynyl-butylcarbamate) Related to the antibacterial mixture.
In this connection, the properties of the diol in the mixture are preferably adjusted in such a way that their anti-microbial action is synergistically enhanced.

In the sense used in the present invention, “paraben” means a C ₁ -C ₄ ester of 4-hydroxybenzoic acid, in particular methylparaben, ethylparaben, n-propylparaben, n-butylparaben, isobutylparaben and mixtures thereof. is there. These parabens can be used alone or in combination for preservation purposes, in particular in cosmetic and pharmaceutical formulations. The most common paraben combination in these formulations is a combination comprising 0.18% by weight methylparaben and 0.02% by weight propylparaben. Potassium sorbate is the potassium salt of sorbic acid (2,4-hexadienoic acid).
The present invention relates to the fungus Aspergillus niger, which is a filamentous fungus, in which the mixture of the present invention is at least in the context of selected bacteria, and in particular may be difficult to kill. It is based on the surprising recognition that it exhibits a synergistically enhanced anti-microbial action.

In particular, it is clear that the mixture according to the invention can be used in a prominent way as a mixture of substances with anti-microbial activity, in order to preserve articles that are particularly perishable if not treated (see description above). became.
Experts in the field should be familiar with the anti-microbial properties of 1,2-alkanediol, but to date, (a) 1,2-hexanediol and 1,2-octanediol and also From any 1,2-pentanediol and / or 1,2-decanediol, and (b) at least one preservative selected from the group consisting of potassium sorbate, parabens and iodopropynylbutylcarbamate (IPBC) There is no indication that the resulting mixture exhibits a clearly improved anti-microbial action (at least in the context of the selected bacteria) in each case.

  WO 03/069994 describes a synergistically effective mixture comprising linear, unbranched 1,2-alkanediols such as 1,2-hexanediol and 1,2-octanediol. The mixtures described here have a good effect on gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa and on yeasts such as Candida albicans. The 1,2-alkanediol mixture described in WO 03/069994 also shows good efficacy against fungi such as Aspergillus niger, but this efficacy is not completely satisfactory. . 0.25% by weight 1,2-hexanediol, 0.25% by weight 1,2-octanediol and 0.05% by weight Euxyl K400 (Yuxyl K400 is 80% by weight 2-phenoxyethanol and 20% by weight 1, The combination (which is a mixture of 2-dibromo-2,4-dicyanobutane) shows improved efficacy in the context of Aspergillus niger, but this bacterium has a 28-day duration of action. However, it is not completely excluded.

EP 1 206 933 relates to mixtures comprising 1,2-octanediol or analogues and preservatives, in particular iodopropynyl butyl carbamate. However, this document does not disclose a mixture comprising 1,2-hexanediol, 1,2-octanediol and a further preservative. Similarly, no studies relating to the efficacy of these described mixtures in the context of Aspergillus niger are disclosed.
Thus, in connection with 1,2-alkanediol mixtures, its lack of efficacy in the case of fungi as filamentous fungi (e.g. `` problem bacteria '' Aspergillus niger) is noteworthy. . Therefore, in the past, in order to completely inhibit fungi as filamentous fungi, it was necessary to use a mixture of 1,2-alkanediol at a high use concentration.

  By the way, the mixture according to the invention exhibits a very powerful synergistic effect, especially with respect to the reduction of the number of bacteria, and individually metered preservatives, potassium sorbate, paraben and iodopropynyl butyl carbamate, or similar concentrations. It was particularly surprising to clearly surpass the mixture of 1,2-hexanediol and 1,2-octanediol in In particular, in each case, a CFU value of 0 (CFU = number of colony forming units) was achieved only for the mixture according to the invention.

  Preference is given to (a) 1,2-hexanediol and 1,2-octanediol and also any 1,2-pentanediol and / or 1,2-decanediol, and also (b) iodopropynylbutylcarbamate ( IPBC). Because of their particularly high potentiating effect, such mixtures are suitable even at low doses of the mixtures according to the invention, in particular to eradicate Aspergillus niger. To completely reduce the number of Aspergillus niger bacteria, (a) 1,2-hexanediol and 1,2-octanediol and also any 1,2-pentanediol and / or 1,2 It is only necessary to add a low proportion of IPBC to the mixture containing decanediol, for example in the range of 2 to 10% by weight, eg simply 5% by weight of IPBC, relative to the component part (a). When the amount of 1,2-hexanediol and 1,2-octanediol and also optional 1,2-pentanediol and / or 1,2-decanediol used is 0.4% by weight, this amount is, for example, In each case, this corresponds to an IPBC amount of just 0.02% by weight or less with respect to the total weight of the final product.

Preferably, the ratio of 1,2-hexanediol and 1,2-octanediol to the total mass of 1,2-alkanediol to be used according to the invention is in the range of 10 to 90% by weight in each case. However, it is preferably in the range of 20 to 80% by mass in each example.
The mixture according to the invention is not only suitable for the storage of perishable products, such as cosmetic products, pharmaceutical products or foodstuffs, but also because it has a synergistically enhanced anti-microbial efficacy Can also be used for the following purposes:
(a) For cosmetic treatment of microorganisms that cause body odor,
(b) For the cosmetic treatment of microorganisms that cause acne,
(c) for the cosmetic treatment of microorganisms causing mycosis, and
(d) For the treatment of microorganisms on or within inanimate objects.

  The mixture according to the invention shows its synergistic effect with respect to a large number of Gram positive bacteria, Gram negative bacteria, fungi as filamentous fungi and yeast. In the context of gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, in relation to yeasts such as Candida albicans, and precisely as already mentioned, For example, it has a particularly good effect in the context of Aspergillus niger. In this connection, the very good efficacy of the mixtures according to the invention is particularly advantageous in the context of Aspergillus niger, a fungus that is a filamentous fungus, which can be very difficult to eradicate. It is thought that it is.

The present invention also provides (a) 1,2-hexanediol and 1,2-octanediol and also any 1,2-pentanediol and / or 1,2-decanediol, and also (b) 1, 2, or It also relates to the use of a mixture comprising or consisting of further substances selected from the group consisting of potassium sorbate, parabens and iodopropynyl butyl carbamate (IPBC) as a mixture of antimicrobial active substances.
Furthermore, the present invention relates to cosmetics and / or microorganisms, in particular (a) microorganisms that cause body odor, (b) microorganisms that cause acne, and / or (c) microorganisms that cause mycosis. Also related to a suitable method for therapeutic treatment, which method comprises the step of topically applying the mixture according to the invention in its anti-microbially effective amount, in the mixture The proportion of the diol is adjusted to synergistically enhance its anti-microbial effect.

The preferred configuration of the method according to the invention corresponds to the preferred configuration of the use according to the invention identified above.
The amount of the alkanediol is typically in the range of 0.1 to 10%, preferably in the range of 0.4 to 5.0%, based on the total mass of the cosmetic composition.
The amount of chelating agent is typically in the range of 0.01 to 1%, preferably in the range of 0.1 to 0.5%, based on the total mass of the cosmetic composition.
The amount of sesquiterpene is typically in the range of 0.01 to 1%, preferably in the range of 0.1 to 0.5%, based on the total mass of the cosmetic composition.
The amount of the tropolone compound is typically in the range of 0.0001 to 10%, preferably in the range of 0.01 to 4%, based on the total mass of the cosmetic composition.
In particular, the amount of potassium sorbate is generally in the range of 0.01 to 0.6%, preferably in the range of 0.05 to 0.4%, particularly preferably in the range of 0.1 to 0.2%, based on the total mass of the cosmetic composition. is there.

The maximum amount of any kind of paraben is 0.4% and the maximum amount of any mixture of parabens is 0.8%. Preferably, the amount of paraben is in the range of 0.01 to 0.4%, more preferably in the range of 0.05 to 0.3%, and particularly preferably in the range of 0.1 to 0.2%, based on the total mass of the cosmetic composition.
In using various preservative combinations, the limits generally depend on the individual desired product (topically applied composition, food product, etc.) and human tolerance (rash, hypersensitivity) Condition, inflammation).
Human skin is populated with a number of different microorganisms, including those already named above as well as others. Most of these microorganisms are non-pathogenic and are independent of the physiological state of the skin and its odor. On the other hand, others can have a decisive impact on skin health.

As some studies have already revealed, the synergistically effective mixtures of the present invention are not only related to the bacteria already described above, but also Staphylococcus epidermidis, Corynebacterium xerosis, Brevibacterium epidermidis, in relation to Propionibacterium acnes, and also Trichophyton and Epidermophyton It is also highly effective in relation to species, and as a treatment (eradication) agent for the odor of the armpit, and the foot odor or general body odor, as an acne eradication agent, and an anti-dandruff agent And as a therapeutic agent for mycosis (especially dermatomycosis).
The term “treatment” within the scope of the present invention means any type that affects the microorganism in question, in which the growth of these microorganisms is inhibited and / or the microorganisms are killed. It is.

  When used as a preservative or antibacterial active substance in foodstuffs or cosmetics or pharmaceutical preparations, the use concentration of the mixture according to the invention is preferably in the range from 0.01 to 30% by weight, particularly preferably from 0.1 to Within the range of 5% by weight, in each example, the reference is the total weight of the food product or formulation. The food product or formulation further comprises known further ingredients, see below for these ingredients. In the mixture according to the invention, the proportions of (a) 1,2-diol and / or (b) preservative to be used according to the invention are considered separately, and the total available amount of these substances is If the mixture is sufficiently high to obtain anti-microbial activity, it may be below its anti-microbial effective amount. This is especially true for the activity associated with Aspergillus niger.

for cosmetically and / or therapeutically treating (a) microorganisms causing body odor, (b) microorganisms causing acne, and / or (c) microorganisms causing mycosis. In the preferred method of the invention, the use concentration of the synergistically effective mixture according to the invention is also in the range of 0.01 to 30% by weight, and particularly preferably in the range of 0.1 to 5% by weight, in any example , The criterion is the total mass of the cosmetic or pharmaceutical product containing the mixture.
In this regard, the synergistically effective mixture can find (a) use for prophylactic purposes or (b) use where necessary.
For example, the amount or concentration of active substance used daily can vary and depends on the physiological condition of the subject being tested and on individual specific parameters such as age or weight. The synergistically effective mixtures according to the invention can find use as such or in combination with further anti-microbially active substances.

Within the scope of the present invention, the 1,2-alkanediol to be used according to the present invention can exist as both the appropriate 2S-configuration and 2R-configuration enantiomers, and these 2S-configuration and 2R -It should be noted the fact that it can exist as any mixture of enantiomers with configuration. For industrial reasons, it is particularly advantageous to use the racemic mixture for each of these 1,2-alkanediols to be used for the purpose of eradicating microorganisms according to the invention, since they can be synthesized particularly easily. However, pure enantiomers or non-racemic mixtures of these enantiomers are also suitable for the purposes of the present invention.
Further uses / methods and mixtures / compositions according to the invention can be deduced from the following embodiments and the appended claims.

In particular, as long as it is used against microorganisms that cause body odor, the composition comprising the mixture according to the present invention is generally applied topically as a solution, cream, lotion, gel, spray or the like. For other purposes, in many cases, oral (tablets, capsules, powders, drops), intravenous, intraocular, intraperitoneal, or intramuscular application, or application as an impregnated dressing makes sense It is practical.
The mixtures according to the invention are commercially available cosmetic or dermatological formulations, such as in particular pump sprays, aerosol sprays, creams, ointments, tinctures, lotions, nail care products (for example nail varnishes, nail varnish removers, nail balsams) ) And the like. In this connection, it is also possible to combine the synergistic mixture according to the invention with further active substances, such as other anti-microbial, anti-fungal or anti-virally active substances. It is also advantageous in some cases. In this regard, cosmetic and / or dermatological / keratinological formulations containing the synergistic mixture according to the present invention can be configured as usual and the dermatological treatment line Or along the treatment line in the field of hairdressing cosmetics to help treat skin and / or hair. However, they can also be used in makeup products in the field of decorative cosmetics.

When the composition according to the invention is used as an active substance for preserving organic substances, it can be advantageous to use one or more preservatives. In this regard, preferably benzoic acid, its esters and salts, propionic acid and its salts, salicylic acid and its salts, formaldehyde and paraformaldehyde, 2-hydroxybiphenyl ether and its salts, 2-zinc sulfide pyridine-N -Oxides, inorganic sulfites and bisulfites, sodium iodate, chlorobutanol, 4-ethylmercury (II) -5-amino-1,3-bis (2-hydroxybenzoic acid), its salts and esters, dehydroacetic acid Formic acid, 1,6-bis (4-amidino-2-bromophenoxy) -n-hexane and its salt, ethylmercury (II) -thiosalicylic acid sodium salt, phenylmercury and its salt, 10-undecylenic acid and its salt Salt, 5-amino-1,3-bis (2-ethylhexyl) -5-methylhexahydropyrimidine, 5-bromo-5-nitro-1,3-dioxane, 2-bromo-2-nitro-1, 3-propanediol, 2,4-dichlorobenzyl alcohol, N- (4-chlorophenyl) -N '-(3,4-dichlorophenyl) urea, 4-chloro-m-cresol, 2,4,4'-trichloro- 2′-hydroxydiphenyl ether, 4-chloro-3,5-dimethylphenol, 1,1′-methylene-bis (3- (1-hydroxymethyl-2,4-dioxyimidazolidin-5-yl) urea), Poly (hexamethylene biguanide) hydrochloride, 2-phenoxyethanol, hexamethylenetetramine, 1- (3-chloroallyl) -3,5,7-triaza-1-azoniaadamantan chloride, 1- (4-chlorophenoxy) -1 -(1H-imidazol-1-yl) -3,3-dimethyl-2-butanone, 1,3-bis (hydroxymethyl) -5,5-dimethyl-2,4-imidazolidinedione, benzyl alcohol, octopi Rocks (Octopirox), 1,2-dibromo-2,4-dicyanobutane, 2,2'-methylene-bis (6-bromo-4-chlorophenol) ), Bromochlorophene, 5-chloro-2-methyl-3 (2H) -isothiazolinone and 2-methyl-3 (2H) -isothiazolinone with magnesium chloride and magnesium nitrate, 2-benzyl-4-chlorophenol 2-chloroacetamide, chlorhexidine, chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, 1-phenoxypropan-2-ol, N-alkyl (C ₁₂ -C ₂₂ ) trimethylammonium bromide and chloride, 4,4-dimethyl-1 , 3-oxazolidine, N-hydroxymethyl-N- (1,3-di (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl) -N'-hydroxymethylurea, 1,6-bis ( 4-Amidinophenoxy) -n-hexane and its salts, glutaraldehyde, 5-ethyl-1-aza-3,7-dioxabicyclo (3.3.0) octane, 3- (4-chlorophenoxy) -1,2 -Professional Njioru, Hyamine (Hyamine), alkyl (C ₈ -C ₁₈₎ - dimethylbenzyl ammonium chloride, alkyl (C ₈ -C ₁₈₎ - dimethylbenzyl ammonium bromide, alkyl (C ₈ -C ₁₈₎ - dimethyl benzyl ammonium saccharinate , Benzyl hemiformal, sodium hydroxymethylaminoacetate or sodium hydroxymethylaminoacetate.

  If the mixture according to the invention is mainly used for inhibiting the growth of unwanted microorganisms on or in the body of an animal, here again with further antibacterial or antifungal active substances. Combinations are advantageous in many cases. In this respect, in addition to the classic large group of antibiotics, those worth mentioning as further active substances are in particular those related to cosmetics, for example triclosan, climbazole, oct Xylglycerin, Octopirox (1-hydroxy-4-methyl-6- (2,4,4-trimethylpentyl) -2 (1H) -pyridone, 2-aminoethanol), chitosan, farnesol, glycerol monolaur Rate, or a combination of these listed substances, which are used in particular to prevent axillary odor, foot odor or desquamation.

The mixtures according to the invention may be advantageous in combination with auxiliary substances, for example as listed below, in particular in cosmetic preparations:
Further preservatives, further antibacterial agents, such as further antibacterial or fungicides, abrasives, anti-acne agents, skin anti-aging agents, anti-Flegmone agents, anti-dandruff agents, anti-inflammatory agents, hypersensitivity Preventive agent, hypersensitivity inhibitor, antioxidant, astringent, antiperspirant, antiseptic, binder, buffer, excipient, chelating agent, cell stimulant, detergent, hair styling agent, hair removal cream, surfactant Substance, deodorant, antiperspirant, emollient, emulsifier, enzyme, essential oil, fiber, film forming agent, fixing agent, foaming agent, foam stabilizer, antifoaming substance, foaming agent, gelling agent, gel forming agent, hair Care agent, hair deforming agent, hair smoothing agent, moisture-imparting agent, moisturizing substance, moisture retention agent, bleaching agent, starching agent, dyeing maintenance agent, fluorescent whitening agent, impregnating agent, dirt Inhibitor, antiwear agent, lubricant, moisturizing cream, Ointment, opacifier, plasticizer, coating agent, abrasive, gloss enhancer, polymer, powder, protein, regreasing agent, abrasion agent, silicone, skin-sedative, skin cleanser, skin Care preparations, skin healing agents, skin-lightening agents, skin protectants, emollients, cooling agents, skin cooling agents, warming agents, skin-warming agents, stabilizers, UV-absorbing agents, UV filters, cleaning agents, softening agents, suspending agents, skin tanning agents, thickeners, vitamins, oils, waxes, fats, phospholipids, saturated fatty acids, mono-unsaturated or poly-unsaturated fatty acids, α-hydroxy Acid, polyhydroxy fatty acid, liquefying agent, dye, paint protective agent, pigment, anticorrosive, fragrance, flavoring substance, fragrance releasing substance, polyol, surfactant, electrolyte, organic solvent or silicone derivative.

  Furthermore, the mixtures according to the invention can also be used particularly advantageously in combination with antiperspirant active substances (anti-publishing agents) for the purpose of eliminating body odor. Aluminum salts such as aluminum chloride, aluminum hydrochloride, aluminum nitrate, aluminum sulfate, aluminum acetate and the like find particular use as antiperspirant actives. However, in addition to these, the use of zinc compounds, magnesium compounds and zirconium compounds can also be advantageous. For practical use in cosmetic and dermatological antiperspirants, the aluminum salt and, to a lesser extent, the aluminum / zirconium salt combination may be valuable. Proven. Also worth mentioning is aluminum hydroxychloride, which is partially neutralized and consequently more compatible with the skin, but not very effective. .

When the mixture according to the invention is used for anti-microbial treatment of a surface (e.g. human or animal body), in many cases a combination with a (metal) chelator is advantageous. is there. The (metal) chelators preferentially used in this respect are in particular α-hydroxy fatty acids, phytinic acids, lactoferrin, α-hydroxy acids, such as in particular citric acid, lactic acid and malic acid. And also humic acid, bile acid, bile extract, bilirubin, biliverdin or EDTA, EGTA and their derivatives.
For practical use, a cosmetically and / or dermatologically effective mixture according to the invention is applied to the skin and / or hair in a manner known for cosmetics and dermatics, Apply in sufficient quantity. Particularly advantageous in this regard is provided by cosmetic and dermatological preparations which comprise the mixtures according to the invention and which additionally function as sunscreens. These formulations advantageously comprise at least one UVA filter and / or at least one UVB filter and / or at least one inorganic pigment. In this case, the formulation can exist in various forms, such as those conventionally used for sunscreen formulations. That is, they are, for example, solutions, water-in-oil (W / O) type, or oil-in-water (O / W) type emulsions, or composite emulsions, such as water-in-oil-in-water (W / O / W) type emulsions, It may be a gel, a hydro-dispersion, a solid stick or an aerosol.

As mentioned above, the formulation comprising the mixture according to the invention can advantageously be combined with a substance that absorbs UV radiation, and the total amount of this filter substance is, for example, 0.01 to 40 mass, relative to the total mass of the formulation. %, Preferably 0.1 to 10% by weight, especially 1.0 to 5.0% by weight, the resulting cosmetic preparation can protect the hair or skin from ultraviolet radiation. To do.
In formulations containing the mixtures according to the invention for the topical prevention or cosmetic treatment of the skin, the use of hair styling substances at a high rate is usually advantageous. In a preferred embodiment, the composition comprises one or more hair styling, animal and / or vegetable oils, such as olive oil, sunflower oil, refined soybean oil, palm oil, sesame oil, rapeseed oil, almond oil, borage oil, Includes evening primrose oil, copra oil, shea fat, jojoba oil, powdered whale oil, beef tallow, beef leg oil, lard, and the like, and optionally further includes hair styling components such as fatty alcohols having 8 to 30 carbon atoms.

Hair styling substances that can be advantageously combined with the synergistic mixture according to the invention further include those listed below:
Ceramide, the term `` ceramide '' is understood to mean N-acyl sphingosine (sphingosine fatty acid amide) or synthetic analogues of such lipids (so-called pseudoceramides), which retain the stratum corneum moisture Obviously improve the ability;
Phospholipids such as soy lecithin, egg lecithin and cephalin;
Petrolatum, paraffin oil and silicone oil, the latter in particular dialkylaryl siloxanes and alkylaryl siloxanes such as dimethylpolysiloxanes and methylphenylpolysiloxanes and also their alkoxylated or quaternized derivatives.
Antioxidants can also be included, in which case any antioxidant suitable or general for cosmetic and / or dermatological applications can be used.

Cosmetic preparations containing the mixtures according to the invention can also contain various vitamins and vitamin precursors, in which case they are suitable or general for cosmetic and / or dermatological applications Any vitamin and vitamin precursor can be used. Worthy of mention here are in particular vitamins and vitamin precursors such as tocopherol, vitamin A, nicotinic acid and nicotinamide, further B-complex vitamins, in particular biotin and vitamin C, panthenol and its derivatives, in particular panthenol. Esters and ethers and cationic derivatized panthenol such as panthenol triacetate, panthenol monoethyl ether and its monoacetate, and also cationic panthenol derivatives.
Cosmetic preparations containing the mixtures according to the invention can also contain anti-inflammatory agents or anti-rediget or antipruritic active substances. In this regard, it is possible to use any anti-inflammatory agent or anti-reddish or anti-pruritic active substance suitable or general for cosmetic and / or dermatological applications. it can.

Cosmetic preparations containing the mixtures according to the invention can also contain active substances with a high degree of skin whitening or skin tanning action. In this regard, according to the present invention, any active substance with a high degree of whitening or tanning of the skin, suitable for cosmetic and / or dermatological applications or general, is used. Can be used.
Furthermore, cosmetic preparations containing the mixtures according to the invention can be anionic, cationic, nonionic and / or non-ionic and / or cationic, especially when crystalline or microcrystalline solids, such as inorganic fine pigments, are to be incorporated into the preparation. Alternatively, amphoteric surfactants can also be included.

The invention will be explained in more detail below on the basis of the following examples. Unless stated otherwise, the figures are based on mass.
Example: Comparison of (i) a mixture consisting of 1,2-hexanediol and 1,2-octanediol and (ii) a mixture according to the invention in a test for sufficient shelf life. Performed according to European Pharmacopoeia.
That is, the test involves contaminating a formulation with the final proportion if possible with a defined inoculum containing the appropriate microorganisms, storing the inoculated formulation at a predetermined temperature, The method includes a step of collecting a sample from the container at a predetermined time interval and a step of determining the number of microorganisms in the sample thus collected. Under these test conditions, after storage at a specified temperature for a specified period of time, if there has been a clear decrease in the number of viable bacteria in the inoculated formulation or, if appropriate, no increase at all, storage Sex is enough. Experimental details of this test procedure can be found in European Pharmacopia (ISBN 3-7692-2768-9; 3rd edition appendix 2001, pp. 412-422, Chapter 5.1.3).

Tested fungus:
The following microbial strains were used for testing to check for sufficient storage:
A: Escherichia coli ATCC 8739;
B: Pseudomonas aeruginosa ATCC 9027;
C: Staphylococcus aureus ATCC 6538;
D: Candida albicans ATCC 10231;
E: Aspergillus niger ATCC 16404.

The initial viable count (CFU / g; “0 value”) in a series of different test groups was in the range of 250,000-320,000.
Formula :
In connection with the test to check for sufficient storage stability, the mixtures according to the invention (active substance combinations B to D, see description below) are separated O / W in the amounts specified in each example. Formulated in a mold emulsion. For comparison purposes, a mixture of 1,2-hexanediol and 1,2-octanediol (active substance A) was blended into another O / W emulsion.
The O / W emulsion used:

pH値：5.5

pH value: 5.5

Result :
For the above-mentioned storage-load test, which relates to the active substance combinations studied, consisting of the mixture according to the invention and the standard system: 1,2-hexanediol / 1,2-octanediol (active substance A; Table A below) The results are shown in Tables A to D below. Here, the synergistic effect of the mixtures according to the invention is indicated in particular by the number of residual viable bacteria on Aspergillus niger which remains after 28 days. In the case of Aspergillus niger, which is a particularly problematic fungus for industrial products, as can be seen from Tables B to D, by using the mixture of the present invention, the number of viable bacteria can be reached within 28 days. Could be reduced to 0. On the other hand, for comparison purposes, the active substance A (1,2-hexanediol + 1,2-octanediol; quantitative ratio: 1: 1) tested at a dose of 0.5% by weight is Aspergillus niger. In this case, such a significant reduction in the number of colony forming units (CFU) was not possible. This series of tests resulted in (a) 1,2-hexanediol, 1,2-octanediol and any 1,2-pentanediol and / or 1,2-decanediol, and (b) potassium sorbate It shows in a typical manner that a mixture of active substances consisting of a further preservative selected from the group consisting of parabens and IPBC can have a synergistic and even improved effect.

Tables A to D : (i) active substance combinations A consisting of 1,2-hexanediol and 1,2-octanediol (reference) and (ii) mixtures according to the invention with an enhanced synergistic effect (of active substances) Test for sufficient storage stability for combinations BD) [CFU / ml].

  The above synergistic enhancement of the efficacy of the active substance combination according to the invention can also be evidenced based on the data obtained by the Kull's formula (FC Kull et al., Applied Microbiology, 1961, 9 : 538-541; David C. Steinberg; Cosmetics & Toiletries, 2000 (November), 115 (No. 11): 59-62).

Claims (7)

(a) 1,2-hexanediol and 1,2-octanediol and also any 1,2-pentanediol and / or 1,2-decanediol, and also
(b) 1, 2 or more substances selected from the group consisting of potassium sorbate, parabens and iodopropynyl butyl carbamate (IPBC);
An antibacterial mixture comprising or consisting of these components. A cosmetic preparation or a pharmaceutical preparation or a food product,
(a) 1,2-hexanediol and 1,2-octanediol and also any 1,2-pentanediol and / or 1,2-decanediol, and also
(b) 1, 2 or more substances selected from the group consisting of potassium sorbate, parabens and iodopropynyl butyl carbamate (IPBC), and also
(c) In addition, known ingredients,
Wherein the total amount of the substances related to the groups (a) and (b) is in the range of 0.01 to 30% by mass relative to the total mass of the preparation or the food product, Cosmetic preparation or pharmaceutical preparation or foodstuff.   In the range of 2 to 10% by mass, based on the total mass of 1,2-hexanediol and 1,2-octanediol and any 1,2-pentanediol and / or 1,2-decanediol used. 3. The antibacterial mixture according to claim 1 or the formulation or foodstuff according to claim 2, which contains IPBC in proportions. (a) 1,2-hexanediol and 1,2-octanediol and also any 1,2-pentanediol and / or 1,2-decanediol, and also
(b) 1, 2 or more substances selected from the group consisting of potassium sorbate, parabens and iodopropynyl butyl carbamate (IPBC);
And the amount of substance related to group (a) and / or the amount of substance related to group (b) is not anti-microbiologically effective, but the group (a) 4. Mixture according to claim 1 or 3, or formulation or foodstuff according to claim 2 or 3, characterized in that the total amount of substances related to a) and (b) is anti-microbially effective. (a) 1,2-hexanediol and 1,2-octanediol and also any 1,2-pentanediol and / or 1,2-decanediol, and also
(b) 1, 2 or more substances selected from the group consisting of potassium sorbate, parabens and iodopropynyl butyl carbamate (IPBC);
A mixture comprising or consisting of these components as a mixture of antimicrobial active substances. A method for storing or anti-microbial treating a perishable product characterized in that it comprises the following steps:
Ingredients listed below in an anti-microbially effective amount, preferably in an amount effective against Aspergillus niger:
(a) 1,2-hexanediol and 1,2-octanediol and also any 1,2-pentanediol and / or 1,2-decanediol, and also
(b) 1, 2 or more substances selected from the group consisting of potassium sorbate, parabens and iodopropynyl butyl carbamate (IPBC);
A mixture comprising or consisting of these components and the perishable product. (i) microorganisms that cause body odor,
(ii) microbes that cause acne and / or
(iii) microorganisms that cause mycosis,
A method for cosmetic and / or therapeutic treatment of the following ingredients:
(a) 1,2-hexanediol and 1,2-octanediol and also any 1,2-pentanediol and / or 1,2-decanediol, and also
(b) 1, 2 or more substances selected from the group consisting of potassium sorbate, parabens and iodopropynyl butyl carbamate (IPBC);
Or a method comprising the step of topically applying an anti-microbially effective amount of a mixture comprising or a mixture of these components.