JP2008515909A5 - - Google Patents
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- Publication number
- JP2008515909A5 JP2008515909A5 JP2007535814A JP2007535814A JP2008515909A5 JP 2008515909 A5 JP2008515909 A5 JP 2008515909A5 JP 2007535814 A JP2007535814 A JP 2007535814A JP 2007535814 A JP2007535814 A JP 2007535814A JP 2008515909 A5 JP2008515909 A5 JP 2008515909A5
- Authority
- JP
- Japan
- Prior art keywords
- estrogen
- daily dose
- phase
- progestin
- doses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940011871 estrogen Drugs 0.000 claims 58
- 239000000262 estrogen Substances 0.000 claims 58
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 48
- 239000000583 progesterone congener Substances 0.000 claims 40
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 32
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims 32
- 229960002568 ethinylestradiol Drugs 0.000 claims 32
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims 16
- 229960004400 levonorgestrel Drugs 0.000 claims 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 8
- 150000002148 esters Chemical class 0.000 claims 8
- -1 guestden Chemical compound 0.000 claims 8
- 229940002612 prodrug Drugs 0.000 claims 8
- 239000000651 prodrug Substances 0.000 claims 8
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 4
- RSEPBGGWRJCQGY-RBRWEJTLSA-N Estradiol valerate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCC)[C@@]1(C)CC2 RSEPBGGWRJCQGY-RBRWEJTLSA-N 0.000 claims 4
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 claims 4
- 229960000978 cyproterone acetate Drugs 0.000 claims 4
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 claims 4
- 229960004976 desogestrel Drugs 0.000 claims 4
- RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 claims 4
- AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 claims 4
- 229960003309 dienogest Drugs 0.000 claims 4
- 229930182833 estradiol Natural products 0.000 claims 4
- 229960005309 estradiol Drugs 0.000 claims 4
- 229960003575 estradiol acetate Drugs 0.000 claims 4
- FHXBMXJMKMWVRG-SLHNCBLASA-N estradiol acetate Chemical compound C1C[C@]2(C)[C@@H](O)CC[C@H]2[C@@H]2CCC3=CC(OC(=O)C)=CC=C3[C@H]21 FHXBMXJMKMWVRG-SLHNCBLASA-N 0.000 claims 4
- 229960004766 estradiol valerate Drugs 0.000 claims 4
- ONKUMRGIYFNPJW-KIEAKMPYSA-N ethynodiol diacetate Chemical compound C1C[C@]2(C)[C@@](C#C)(OC(C)=O)CC[C@H]2[C@@H]2CCC3=C[C@@H](OC(=O)C)CC[C@@H]3[C@H]21 ONKUMRGIYFNPJW-KIEAKMPYSA-N 0.000 claims 4
- 229960002941 etonogestrel Drugs 0.000 claims 4
- GCKFUYQCUCGESZ-BPIQYHPVSA-N etonogestrel Chemical compound O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 GCKFUYQCUCGESZ-BPIQYHPVSA-N 0.000 claims 4
- IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 claims 4
- 229960001390 mestranol Drugs 0.000 claims 4
- 229940053934 norethindrone Drugs 0.000 claims 4
- 229960001652 norethindrone acetate Drugs 0.000 claims 4
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims 4
- 229960000417 norgestimate Drugs 0.000 claims 4
- KIQQMECNKUGGKA-NMYWJIRASA-N norgestimate Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C\1 KIQQMECNKUGGKA-NMYWJIRASA-N 0.000 claims 4
- 229960003387 progesterone Drugs 0.000 claims 4
- 239000000186 progesterone Substances 0.000 claims 4
- 229950008546 trimegestone Drugs 0.000 claims 4
- JUNDJWOLDSCTFK-MTZCLOFQSA-N trimegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)[C@@H](O)C)(C)[C@@]1(C)CC2 JUNDJWOLDSCTFK-MTZCLOFQSA-N 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61642404P | 2004-10-07 | 2004-10-07 | |
| US68456805P | 2005-05-26 | 2005-05-26 | |
| PCT/US2005/035997 WO2006042021A2 (en) | 2004-10-07 | 2005-10-07 | Methods of hormonal treatment utilizing ascending-dose extended cycle regimens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008515909A JP2008515909A (ja) | 2008-05-15 |
| JP2008515909A5 true JP2008515909A5 (OSRAM) | 2009-05-07 |
Family
ID=36001184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007535814A Pending JP2008515909A (ja) | 2004-10-07 | 2005-10-07 | 上昇用量延長サイクル療法を利用するホルモン処置の方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20060135496A1 (OSRAM) |
| EP (3) | EP2392333A1 (OSRAM) |
| JP (1) | JP2008515909A (OSRAM) |
| AR (1) | AR051931A1 (OSRAM) |
| AU (1) | AU2005294269B2 (OSRAM) |
| BR (1) | BRPI0516247A (OSRAM) |
| CA (1) | CA2582530A1 (OSRAM) |
| IL (1) | IL182287A0 (OSRAM) |
| MX (1) | MX2007004120A (OSRAM) |
| TW (1) | TW200626161A (OSRAM) |
| WO (1) | WO2006042021A2 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050032756A1 (en) * | 1995-10-28 | 2005-02-10 | Michael Dittgen | Multistage preparation for contraception based on natural estrogens |
| CN100581550C (zh) * | 2001-12-05 | 2010-01-20 | 杜拉美德药物有限公司 | 预防怀孕和减少经期前症状的口服避孕药 |
| KR100518152B1 (ko) * | 2002-05-09 | 2005-09-29 | 메디제네스(주) | 혈장 또는 혈청을 함유한 창상 치료용 약학 조성물 |
| WO2005007112A2 (en) * | 2003-07-16 | 2005-01-27 | Duramed Pharmaceuticals, Inc. | Methods of hormonal treatment utilizing contraceptive regimens with continuous estrogen administration |
| DE102004019743B4 (de) * | 2004-04-20 | 2008-11-27 | Bayer Schering Pharma Aktiengesellschaft | Mehrphasenpräparat zur Kontrazeption auf der Basis eines natürlichen Estrogens |
| US20070111975A1 (en) * | 2004-10-07 | 2007-05-17 | Duramed Pharmaceuticals, Inc. | Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens |
| US8153616B2 (en) * | 2005-10-17 | 2012-04-10 | Bayer Pharma Aktiengesellschaft | Combination preparation for oral contraception and oral therapy of dysfunctional uterine bleeding containing estradiol valerate and dienogest and method of using same |
| EP2034984A4 (en) | 2006-06-02 | 2013-03-06 | Pear Tree Women S Health Care | PROCESS FOR TREATING ATROPHIC VAGINITIS |
| EP1930010A1 (de) * | 2006-10-20 | 2008-06-11 | Bayer Schering Pharma Aktiengesellschaft | Verwendung von Estradiolvalerat oder 17ß-Estradiol in Kombination mit Dienogest zur oralen Therapie für den Erhalt und/oder die Steigerung der weiblichen Libido |
| US8828981B2 (en) | 2007-02-06 | 2014-09-09 | George Creasy | Progesterone for the treatment or prevention of spontaneous preterm birth |
| CA2740004A1 (en) | 2008-10-08 | 2010-04-15 | Agile Therapeutics, Inc. | Transdermal delivery |
| US9198919B2 (en) | 2008-10-08 | 2015-12-01 | Agile Therapeutics, Inc. | Contraceptive transdermal delivery of hormones |
| ES2734510T3 (es) | 2008-10-08 | 2019-12-10 | Agile Therapeutics Inc | Administración transdérmica |
| WO2010111488A1 (en) | 2009-03-27 | 2010-09-30 | Agile Therapeutics, Inc. | Transdermal delivery |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4544554A (en) * | 1983-09-26 | 1985-10-01 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
| US4616006A (en) * | 1983-09-26 | 1986-10-07 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
| US4628051A (en) * | 1983-09-26 | 1986-12-09 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
| US4530839A (en) * | 1983-09-26 | 1985-07-23 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
| US4962098A (en) * | 1987-06-15 | 1990-10-09 | Warner-Lambert Company | Graduated estrogen contraceptive |
| US5010070A (en) * | 1987-06-15 | 1991-04-23 | Warner-Lambert Company | Graduated estrogen contraceptive |
| IE61236B1 (en) | 1986-07-15 | 1994-10-19 | American Home Prod | Combination dosage form for pre-menopausal women |
| IE71203B1 (en) * | 1990-12-13 | 1997-02-12 | Akzo Nv | Low estrogen oral contraceptives |
| US5747480A (en) * | 1996-05-08 | 1998-05-05 | American Home Products Corporation | Oral contraceptive |
| WO1998004246A2 (en) * | 1996-07-26 | 1998-02-05 | American Home Prod | Triphasic contraceptive method and kit comprising a combination of a progestin and estrogen |
| US5858405A (en) * | 1996-07-26 | 1999-01-12 | American Home Products Corporation | Oral contraceptive |
| US6028064A (en) * | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
| US5898032A (en) * | 1997-06-23 | 1999-04-27 | Medical College Of Hampton Roads | Ultra low dose oral contraceptives with less menstrual bleeding and sustained efficacy |
| US6251956B1 (en) * | 1998-08-20 | 2001-06-26 | Ortho Pharmaceutical Corporation | Combination progestin oral contraceptive regimen |
| US6214815B1 (en) * | 1998-12-23 | 2001-04-10 | Ortho-Mcneil Pharmaceuticals, Inc. | Triphasic oral contraceptive |
| US7297688B2 (en) * | 2000-06-08 | 2007-11-20 | Wyeth | Starter kit for low dose oral contraceptives |
| CN100581550C (zh) * | 2001-12-05 | 2010-01-20 | 杜拉美德药物有限公司 | 预防怀孕和减少经期前症状的口服避孕药 |
| US20030219471A1 (en) * | 2002-03-11 | 2003-11-27 | Caubel Patrick Michel | Extended cycle estrogen and sulfatase inhibiting progestogen contraceptive regimens |
| US20030216366A1 (en) * | 2002-04-03 | 2003-11-20 | Leonard Thomas W. | Step-down estrogen therapy |
| EP1624848A4 (en) * | 2003-05-02 | 2009-02-25 | Duramed Pharmaceuticals Inc | METHOD FOR HORMONY TREATMENT WITH CONTRAZEPTVA SCHEMATES WITH EXTENDED CYCLE |
| WO2005007112A2 (en) * | 2003-07-16 | 2005-01-27 | Duramed Pharmaceuticals, Inc. | Methods of hormonal treatment utilizing contraceptive regimens with continuous estrogen administration |
| AU2004277998A1 (en) * | 2003-10-01 | 2005-04-14 | Janssen Pharmaceutica N.V. | Extended triphasic contraceptive regimens |
| US20070111975A1 (en) * | 2004-10-07 | 2007-05-17 | Duramed Pharmaceuticals, Inc. | Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens |
-
2005
- 2005-10-07 CA CA002582530A patent/CA2582530A1/en not_active Abandoned
- 2005-10-07 EP EP10184616A patent/EP2392333A1/en not_active Withdrawn
- 2005-10-07 JP JP2007535814A patent/JP2008515909A/ja active Pending
- 2005-10-07 US US11/245,471 patent/US20060135496A1/en not_active Abandoned
- 2005-10-07 WO PCT/US2005/035997 patent/WO2006042021A2/en not_active Ceased
- 2005-10-07 EP EP10184480A patent/EP2392332A1/en not_active Withdrawn
- 2005-10-07 TW TW094135177A patent/TW200626161A/zh unknown
- 2005-10-07 EP EP05810167A patent/EP1814556A2/en not_active Withdrawn
- 2005-10-07 AR ARP050104239A patent/AR051931A1/es unknown
- 2005-10-07 MX MX2007004120A patent/MX2007004120A/es not_active Application Discontinuation
- 2005-10-07 BR BRPI0516247-5A patent/BRPI0516247A/pt not_active IP Right Cessation
- 2005-10-07 AU AU2005294269A patent/AU2005294269B2/en not_active Ceased
-
2007
- 2007-03-29 IL IL182287A patent/IL182287A0/en unknown
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