JP2008510775A - モノアミン神経伝達物質再取込み阻害剤としての新規な置換アリールオキシアルキルアミン及びそれらの使用 - Google Patents

モノアミン神経伝達物質再取込み阻害剤としての新規な置換アリールオキシアルキルアミン及びそれらの使用 Download PDF

Info

Publication number
JP2008510775A
JP2008510775A JP2007528850A JP2007528850A JP2008510775A JP 2008510775 A JP2008510775 A JP 2008510775A JP 2007528850 A JP2007528850 A JP 2007528850A JP 2007528850 A JP2007528850 A JP 2007528850A JP 2008510775 A JP2008510775 A JP 2008510775A
Authority
JP
Japan
Prior art keywords
disorder
pain
methylamine
enyl
hex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2007528850A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008510775A5 (https=
Inventor
エリクセン、ビアギッテ、エル.
ペータース、ダン
ニールセン、エルセベット、オステルガールト
− クリューガー、ヨルゲン シェール
オルセン、グンナー、エム.
Original Assignee
ノイロサーチ アクティーゼルスカブ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ノイロサーチ アクティーゼルスカブ filed Critical ノイロサーチ アクティーゼルスカブ
Publication of JP2008510775A publication Critical patent/JP2008510775A/ja
Publication of JP2008510775A5 publication Critical patent/JP2008510775A5/ja
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/44Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/46Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2007528850A 2004-08-26 2005-08-24 モノアミン神経伝達物質再取込み阻害剤としての新規な置換アリールオキシアルキルアミン及びそれらの使用 Abandoned JP2008510775A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200401290 2004-08-26
US60517504P 2004-08-30 2004-08-30
PCT/EP2005/054151 WO2006021564A1 (en) 2004-08-26 2005-08-24 Novel substituted aryloxy alkylamines and their use as monoamine neurotransmitter re-uptake inhibitors

Publications (2)

Publication Number Publication Date
JP2008510775A true JP2008510775A (ja) 2008-04-10
JP2008510775A5 JP2008510775A5 (https=) 2008-09-11

Family

ID=35134278

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007528850A Abandoned JP2008510775A (ja) 2004-08-26 2005-08-24 モノアミン神経伝達物質再取込み阻害剤としての新規な置換アリールオキシアルキルアミン及びそれらの使用

Country Status (4)

Country Link
US (1) US7973082B2 (https=)
EP (1) EP1784381A1 (https=)
JP (1) JP2008510775A (https=)
WO (1) WO2006021564A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108558618A (zh) * 2018-05-28 2018-09-21 朱晓萍 一种制备2,3-二氟苯酚的方法
CN108586204A (zh) * 2018-05-28 2018-09-28 朱晓萍 一种2,3-二氟苯酚的合成工艺
US11691790B2 (en) 2019-01-18 2023-07-04 S.C. Johnson & Son, Inc. Storage bag with improved gripping features

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1094985A (en) * 1964-07-07 1967-12-13 Wellcome Found Amidine derivatives, processes for their preparation, and compositions incorporating them
GB1079747A (en) * 1965-07-07 1967-08-16 Ici Ltd Alkene derivatives
DE3017812A1 (de) 1980-05-09 1981-11-12 Merck Patent Gmbh, 6100 Darmstadt Cyclopropanderivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
KR880007433A (ko) 1986-12-22 1988-08-27 메리 앤 터커 3-아릴옥시-3-치환된 프로판아민
US4956388A (en) 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
JP2584807B2 (ja) * 1987-12-25 1997-02-26 サントリー株式会社 マレイミド誘導体、その製造法およびそれを有効成分として含有する農園芸用殺菌剤
CA2071474A1 (en) * 1991-06-19 1992-12-20 Hisato Itoh Phthalocyanine compounds and usage thereof
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US6140033A (en) * 1998-12-22 2000-10-31 Eastman Kodak Company Photographic element
GB0004152D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
GB0112122D0 (en) 2001-05-18 2001-07-11 Lilly Co Eli Heteroaryloxy 3-substituted propanamines
AU2003287024A1 (en) 2002-11-05 2004-06-03 Eli Lilly And Company 3-aryloxy/thio-3-substituted propanamines and their use in inhibiting serotonin and norephinephrine reuptake

Also Published As

Publication number Publication date
US20090215905A1 (en) 2009-08-27
WO2006021564A1 (en) 2006-03-02
EP1784381A1 (en) 2007-05-16
US7973082B2 (en) 2011-07-05

Similar Documents

Publication Publication Date Title
US20040106643A1 (en) Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP5001156B2 (ja) 新規クロメン−2−オン誘導体及びモノアミン神経伝達物質再取込阻害剤としてのその使用
JP2009526815A (ja) 1−フェネチルピペリジン誘導体及びオピオイド受容体リガンドとしてのその使用
JP2010513392A (ja) 新規クロメン−2−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用
JP2008502651A (ja) モノアミン神経伝達物質再取込み阻害剤としての、新規アルキル置換ピペリジン誘導体及びその使用
JP2009526022A (ja) 3,9−ジアザビシクロ[3.3.1]ノナン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのその使用
JP2008510775A (ja) モノアミン神経伝達物質再取込み阻害剤としての新規な置換アリールオキシアルキルアミン及びそれらの使用
JP2010513391A (ja) 新規クロメン−2−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用
JP2006507363A (ja) 新規ピペリジン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
JP2009526023A (ja) 3,9−ジアザビシクロ[3.3.1]ノナン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのその使用
JP2008510776A (ja) モノアミン神経伝達物質再取込み阻害剤としての新規な置換ヘテロアリールオキシアルキルアミン及びそれらの使用
JP2008502650A (ja) 新規な9−アザ−ビシクロ[3.3.1]ノナン誘導体及びこれらのモノアミン神経伝達物質再取り込み阻害剤としての使用
US20080176856A1 (en) Novel Alkyl Substituted Piperidine Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors
JP2008546826A (ja) 新規な3,9−ジアザ−スピロ[5.5]ウンデカン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用
US7923444B2 (en) Alkyl substituted homopiperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP2008546828A (ja) 新規な3−アザ−スピロ[5.5]ウンデカン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用
JP2010501624A (ja) 新規なピペリジン誘導体及びモノアミン神経伝達物質再取込み阻害剤としてのその使用
JP2008534653A (ja) 新規エナンチオマー及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用
JP2010535175A (ja) N−アリール−n−ピペリジン−4−イルメチルアミド誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのその使用
JP2008546827A (ja) 新規な3−アザ−スピロ[5.5]ウンデカ−8−エン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用
JP2009507002A (ja) モノアミン神経伝達物質再取り込み阻害剤としての新規アザビシクロ[3.2.1]オクト−2−エン誘導体及びその使用
HK1106514A (en) Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP2011513461A (ja) ニコチン性アセチルコリン受容体モジュレーターとして有用な新規な1,4−ジアザ−ビシクロ[3.2.1]オクタン誘導体
JP2011510040A (ja) 4−フェニル−ピペラジン−1−イル−アルキル−ベンゾイミダゾール−2−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてそれらの使用
HK1103736A (en) Novel alkyl substituted piperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080725

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080725

A762 Written abandonment of application

Free format text: JAPANESE INTERMEDIATE CODE: A762

Effective date: 20110224