JP2008509183A5 - - Google Patents
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- Publication number
- JP2008509183A5 JP2008509183A5 JP2007525243A JP2007525243A JP2008509183A5 JP 2008509183 A5 JP2008509183 A5 JP 2008509183A5 JP 2007525243 A JP2007525243 A JP 2007525243A JP 2007525243 A JP2007525243 A JP 2007525243A JP 2008509183 A5 JP2008509183 A5 JP 2008509183A5
- Authority
- JP
- Japan
- Prior art keywords
- thiophene
- quinoline
- isoxazole
- indane
- naphthyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N Imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 2
- CTAPFRYPJLPFDF-UHFFFAOYSA-N Isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 2
- UGUHFDPGDQDVGX-UHFFFAOYSA-N 1,2,3-thiadiazole Chemical compound C1=CSN=N1 UGUHFDPGDQDVGX-UHFFFAOYSA-N 0.000 description 1
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical compound N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N 289-95-2 Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2H-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 description 1
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N Indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 description 1
- YBYIRNPNPLQARY-UHFFFAOYSA-N Indene Chemical compound C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 description 1
- AWJUIBRHMBBTKR-UHFFFAOYSA-N Isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 description 1
- ZLTPDFXIESTBQG-UHFFFAOYSA-N Isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 description 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N Pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
- 125000004429 atoms Chemical group 0.000 description 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 description 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 description 1
- KAESVJOAVNADME-UHFFFAOYSA-N pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 1
- BSUNTQCMCCQSQH-UHFFFAOYSA-N triazine Chemical compound C1=CN=NN=C1.C1=CN=NN=C1 BSUNTQCMCCQSQH-UHFFFAOYSA-N 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
Description
本明細書で用いる“５員から１０員のヘテロ環式環（ここで、少なくとも１個の環原子は、窒素、酸素および硫黄からなる群から選択される。）”は、飽和または不飽和であり得、例えばピロール、ピロリジン、ピラゾール、イミダゾール、トリアゾール、テトラゾール、チアジアゾール、オキサゾール、イソオキサゾール、チオフェン、イソチアゾール、オキサジアゾール、ピリジン、ピラジン、ピリダジン、ピリミジン、ピペラジン、トリアジン、オキサジン、チアゾール、モルホリノ、キノリン、イソキノリン、ナフチリジン、インダンまたはインデンを含む。好ましいヘテロ環式環は、イソオキサゾール、チオフェンおよびキノリンを含む。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0417804.2A GB0417804D0 (en) | 2004-08-10 | 2004-08-10 | Organic compounds |
| PCT/EP2005/008648 WO2006015851A1 (en) | 2004-08-10 | 2005-08-09 | Piperazine derivatives with ccr3 inhibiting activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008509183A JP2008509183A (ja) | 2008-03-27 |
| JP2008509183A5 true JP2008509183A5 (ja) | 2008-09-25 |
Family
ID=33017257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007525243A Pending JP2008509183A (ja) | 2004-08-10 | 2005-08-09 | Ｃｃｒ３阻害活性を有するピペラジン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7482347B2 (ja) |
| EP (1) | EP1778671B1 (ja) |
| JP (1) | JP2008509183A (ja) |
| CN (1) | CN1993352B (ja) |
| AT (1) | ATE488512T1 (ja) |
| AU (1) | AU2005270305B2 (ja) |
| BR (1) | BRPI0514308A (ja) |
| CA (1) | CA2574292A1 (ja) |
| DE (1) | DE602005024816D1 (ja) |
| GB (1) | GB0417804D0 (ja) |
| MX (1) | MX2007001643A (ja) |
| RU (1) | RU2007108658A (ja) |
| WO (1) | WO2006015851A1 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008123582A1 (ja) | 2007-04-04 | 2008-10-16 | Kowa Company, Ltd. | テトラヒドロイソキノリン化合物 |
| AU2018347447B2 (en) * | 2017-10-13 | 2024-03-07 | Alkahest, Inc. | Methods and compositions for treating pruritus, xerosis, and associated disease using CCR3-inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20013940A3 (cs) * | 1999-05-04 | 2002-04-17 | Schering Corporation | Piperazinové deriváty uľitečné jako CCR5 antagonisté |
| AR033517A1 (es) * | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
| SE0202838D0 (sv) * | 2002-09-24 | 2002-09-24 | Astrazeneca Ab | Chemical compounds |
-
2004
- 2004-08-10 GB GBGB0417804.2A patent/GB0417804D0/en not_active Ceased
-
2005
- 2005-08-09 WO PCT/EP2005/008648 patent/WO2006015851A1/en active Application Filing
- 2005-08-09 EP EP05785272A patent/EP1778671B1/en not_active Not-in-force
- 2005-08-09 JP JP2007525243A patent/JP2008509183A/ja active Pending
- 2005-08-09 AU AU2005270305A patent/AU2005270305B2/en not_active Ceased
- 2005-08-09 AT AT05785272T patent/ATE488512T1/de not_active IP Right Cessation
- 2005-08-09 RU RU2007108658/04A patent/RU2007108658A/ru not_active Application Discontinuation
- 2005-08-09 CA CA002574292A patent/CA2574292A1/en not_active Abandoned
- 2005-08-09 DE DE602005024816T patent/DE602005024816D1/de active Active
- 2005-08-09 MX MX2007001643A patent/MX2007001643A/es active IP Right Grant
- 2005-08-09 US US11/572,652 patent/US7482347B2/en not_active Expired - Fee Related
- 2005-08-09 CN CN2005800265675A patent/CN1993352B/zh not_active Expired - Fee Related
- 2005-08-09 BR BRPI0514308-0A patent/BRPI0514308A/pt not_active IP Right Cessation
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