JP2008505190A - 骨の形成と再構築のための組成物および方法 - Google Patents
骨の形成と再構築のための組成物および方法 Download PDFInfo
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- JP2008505190A JP2008505190A JP2007527363A JP2007527363A JP2008505190A JP 2008505190 A JP2008505190 A JP 2008505190A JP 2007527363 A JP2007527363 A JP 2007527363A JP 2007527363 A JP2007527363 A JP 2007527363A JP 2008505190 A JP2008505190 A JP 2008505190A
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- Prior art keywords
- receptor
- protein
- lrp5
- bone
- lrp6
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- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims 62
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Classifications
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/849,067 US8637506B2 (en) | 2003-09-22 | 2004-05-19 | Compositions and methods for bone formation and remodeling |
| PCT/US2005/017199 WO2005115354A2 (en) | 2004-05-19 | 2005-05-18 | Compositions and methods for bone formation and remodeling |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008505190A true JP2008505190A (ja) | 2008-02-21 |
| JP2008505190A5 JP2008505190A5 (cg-RX-API-DMAC10.html) | 2008-07-03 |
Family
ID=35451375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527363A Pending JP2008505190A (ja) | 2004-05-19 | 2005-05-18 | 骨の形成と再構築のための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8637506B2 (cg-RX-API-DMAC10.html) |
| EP (3) | EP3150255A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2008505190A (cg-RX-API-DMAC10.html) |
| CN (1) | CN101316627A (cg-RX-API-DMAC10.html) |
| CA (6) | CA2772029C (cg-RX-API-DMAC10.html) |
| IL (1) | IL179241A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2005115354A2 (cg-RX-API-DMAC10.html) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008536816A (ja) * | 2005-03-18 | 2008-09-11 | エンゾー バイオケム，インコーポレイテッド | スクレロスチンおよびＷｎｔシグナル伝達ならびに骨形成の阻止阻害 |
| JP2010537950A (ja) * | 2006-11-14 | 2010-12-09 | エンゾー セラピューティクス， インコーポレイテッド | 骨形成および骨リモデリングのための組成物および方法 |
| KR101303941B1 (ko) | 2011-03-31 | 2013-09-05 | 연세대학교 산학협력단 | 피마자 추출물을 유효성분으로 함유하는 골 질환 예방 및 치료용 조성물 |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770461B1 (en) * | 1998-10-23 | 2004-08-03 | Genome Therapeutics Corporation | High bone mass gene of 11q13.3 |
| US6780609B1 (en) * | 1998-10-23 | 2004-08-24 | Genome Therapeutics Corporation | High bone mass gene of 1.1q13.3 |
| BR0209563A (pt) * | 2001-05-11 | 2004-12-07 | Genome Theraupeutics Corp | ácido nucleico, polipeptìdeo, vetor, célula, anticorpo, métodos de diagnosticar um fenótipo e um paciente como expressando um ácido nucleico e de identificar agentes que modulam a atividade de um ácido nucleico e de uma proteìna e lrp5, lrp6, ou hbm e compostos que modulam a interação de dkk com o caminho de sinalização wnt, composição para modular a massa óssea e/ou os nìveis de lipìdeo em um paciente, animal transgênico, embrião e modelo de animal, e, agente |
| US20040221326A1 (en) * | 2001-05-11 | 2004-11-04 | Philip Babij | Transgenic animal model of bone mass modulation |
| US20030219793A1 (en) * | 2002-10-04 | 2003-11-27 | Carulli John P. | High bone mass gene of 11q13.3 |
| US7485460B2 (en) * | 2003-05-21 | 2009-02-03 | Tulane University Health Sciences Center | Enhanced growth of adult stem cells with Dkk-1 |
| US8637506B2 (en) * | 2003-09-22 | 2014-01-28 | Enzo Biochem, Inc. | Compositions and methods for bone formation and remodeling |
| US20100041599A1 (en) * | 2006-11-14 | 2010-02-18 | Dakai Liu | Compositions and methods for bone formation, bone remodeling and toxin protection |
| US9046537B2 (en) | 2003-09-22 | 2015-06-02 | Enzo Biochem, Inc. | Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain |
| US20120178697A9 (en) * | 2003-09-22 | 2012-07-12 | Jie Zheng | Compositions and methods for the inhibition of dishevelled proteins |
| US8343922B2 (en) * | 2004-05-19 | 2013-01-01 | Enzo Biochem, Inc. | Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells |
| US9052324B2 (en) | 2004-05-19 | 2015-06-09 | Enzo Biochem, Inc. | Compounds and assays for controlling Wnt activity |
| CA2685737A1 (en) * | 2007-04-30 | 2008-11-06 | Washington University | Methods and compositions for the treatment of cancer |
| WO2008144659A2 (en) * | 2007-05-18 | 2008-11-27 | Board Of Regents, The University Of Texas System | Dickkopf-1 (dkk1) as a universal tumor vaccine for immunotherapy of cancers |
| MX2010004761A (es) | 2007-11-02 | 2010-05-19 | Novartis Ag | Moleculas y metodos para modular la proteina relacionada con el receptor de lipoproteina de baja densidad 6 (lrp6). |
| EP3211011A1 (en) | 2007-11-16 | 2017-08-30 | Nuvelo, Inc. | Antibodies to lrp6 |
| US8716243B2 (en) | 2008-05-28 | 2014-05-06 | St. Jude Childen's Research Hospital | Methods of effecting Wnt signaling through Dkk structural analysis |
| EP2408466B1 (en) * | 2009-03-18 | 2015-10-21 | The Brigham and Women's Hospital, Inc. | Dikkopf2 (Dkk2) and active fragments thereof for use in the treatment of kidney or pancreas injuries |
| AR076668A1 (es) | 2009-05-12 | 2011-06-29 | Pfizer | Anticuerpos especificos para dkk-1 y sus usos |
| MX2012012927A (es) | 2010-05-06 | 2013-05-01 | Novartis Ag | Composiciones y metodos de uso para anticuerpos multivalentes terapeuticos de proteina relacionada con lipoproteina de baja densidad 6 (lrp6). |
| SG185416A1 (en) | 2010-05-06 | 2012-12-28 | Novartis Ag | Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies |
| US9617323B2 (en) | 2010-06-07 | 2017-04-11 | Joshua Rabbani | Sulfonated sclerostin, antibodies, epitopes and methods for identification and use therefor |
| US11167011B2 (en) | 2010-06-07 | 2021-11-09 | Enzo Biochem, Inc. | Methods for treating bone loss using sclerostin peptides |
| US9403882B2 (en) | 2010-06-07 | 2016-08-02 | Joshua Rabbani | Sulfation of Wnt pathway proteins |
| US9493541B2 (en) | 2010-06-07 | 2016-11-15 | Joshua Rabbani | Antibodies specific for sulfated sclerostin |
| CN103476791A (zh) * | 2011-01-11 | 2013-12-25 | 菲特治疗公司 | 新型wnt组合物和该组合物的治疗用途 |
| US8883735B2 (en) | 2011-11-04 | 2014-11-11 | Novartis Ag | Low density lipoprotein-related protein 6 (LRP6)-half life extender constructs |
| CN103966229A (zh) * | 2014-05-09 | 2014-08-06 | 中山大学 | bbeAMP基因、其编码的蛋白质、以bbeAMP为目的基因生产的融合蛋白及其应用 |
| JP6796059B2 (ja) | 2014-09-12 | 2020-12-02 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Ｗｎｔシグナリングアゴニスト分子 |
| CN106367517A (zh) * | 2016-09-28 | 2017-02-01 | 湖北工业大学 | 一种低密度脂蛋白受体相关蛋白5基因突变检测的试剂及应用 |
| CN118271444A (zh) | 2017-12-19 | 2024-07-02 | 瑟罗泽恩奥普瑞汀公司 | Wnt替代分子和其用途 |
| CN111699003B (zh) | 2017-12-19 | 2024-05-03 | 瑟罗泽恩奥普瑞汀公司 | 抗lrp5/6抗体和使用方法 |
| JP7418332B2 (ja) | 2017-12-19 | 2024-01-19 | スロゼン オペレーティング， インコーポレイテッド | 抗フリズルド抗体及び使用方法 |
| CN111632147A (zh) * | 2020-06-07 | 2020-09-08 | 重庆医科大学 | 骨细胞Wnt激活剂在制备骨折加速愈合、防治骨不连及不运动或失重骨丢失药物中的应用 |
| EP4398990A4 (en) * | 2021-09-08 | 2025-07-16 | Baylor College Medicine | METHODS AND COMPOSITIONS FOR IMMUNE REGULATION BY DICKKOPF-1 |
| CN115309402B (zh) * | 2022-07-13 | 2023-10-24 | 国网江苏省电力有限公司信息通信分公司 | 一种可量化差异的异构执行程序集合构成方法及装置 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002092015A2 (en) * | 2001-05-17 | 2002-11-21 | Genome Therapeutics Corporation | Reagents and methods for modulating dkk-mediated interactions |
| WO2003106657A2 (en) * | 2002-06-14 | 2003-12-24 | Stowers Institute For Medical Research | Wise/sost nucleic acid sequences and amino acid sequences |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS562623A (en) * | 1979-06-21 | 1981-01-12 | Matsushita Electric Industrial Co Ltd | Electrode |
| EP0639889B1 (en) * | 1993-08-19 | 1999-09-15 | Advanced Micro Devices, Inc. | Low voltage fully differential operational amplifiers |
| US7244577B2 (en) * | 1997-04-15 | 2007-07-17 | Merck & Co., Inc. | Method of screening for modulator of LRP5 activity |
| DE19747418C1 (de) * | 1997-10-27 | 1999-07-15 | Deutsches Krebsforsch | Inhibitor-Protein des wnt-Signalwegs |
| US20040009535A1 (en) * | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
| CA2366062C (en) * | 1999-03-05 | 2014-06-17 | Millennium Pharmaceuticals, Inc. | Human dickkopf-related protein and nucleic acid molecules and uses therefor |
| WO2001073019A1 (de) * | 2000-03-29 | 2001-10-04 | Max-Planck-Gesellschaft | Raumform von tpr-strukturmotiv enthaltenden polypeptiden mit chaperon-bindungsfunktion, deren kristalle und verbindungen zur inhibierung derartiger polypeptide |
| US7713526B2 (en) * | 2001-05-01 | 2010-05-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
| US20040038860A1 (en) * | 2002-05-17 | 2004-02-26 | Allen Kristina M. | Reagents and methods for modulating dkk-mediated interactions |
| CA2465499A1 (en) * | 2001-11-08 | 2003-05-15 | Merck & Co., Inc. | Compositions and methods for treating osteoporosis |
| US20050084494A1 (en) * | 2003-05-21 | 2005-04-21 | Darwin Prockop | Inhibitors of Dkk-1 |
| US8637506B2 (en) | 2003-09-22 | 2014-01-28 | Enzo Biochem, Inc. | Compositions and methods for bone formation and remodeling |
| US20120178697A9 (en) | 2003-09-22 | 2012-07-12 | Jie Zheng | Compositions and methods for the inhibition of dishevelled proteins |
| US9046537B2 (en) * | 2003-09-22 | 2015-06-02 | Enzo Biochem, Inc. | Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain |
| US8367822B2 (en) * | 2003-09-22 | 2013-02-05 | Enzo Therapeutics, Inc. | Compositions and methods for bone formation and remodeling |
| US8461155B2 (en) | 2003-09-22 | 2013-06-11 | University Of Connecticut | Sclerostin and the inhibition of WNT signaling and bone formation |
| US8343922B2 (en) * | 2004-05-19 | 2013-01-01 | Enzo Biochem, Inc. | Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells |
| ES2414460T3 (es) * | 2004-08-04 | 2013-07-19 | Amgen Inc. | Anticuerpos para Dkk-1 |
| WO2006089114A2 (en) * | 2005-02-17 | 2006-08-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating an anthrax toxin mediated condition |
-
2004
- 2004-05-19 US US10/849,067 patent/US8637506B2/en not_active Expired - Lifetime
-
2005
- 2005-05-18 EP EP16000780.3A patent/EP3150255A1/en not_active Withdrawn
- 2005-05-18 JP JP2007527363A patent/JP2008505190A/ja active Pending
- 2005-05-18 WO PCT/US2005/017199 patent/WO2005115354A2/en not_active Ceased
- 2005-05-18 CA CA2772029A patent/CA2772029C/en not_active Expired - Lifetime
- 2005-05-18 EP EP05751764A patent/EP1758562B1/en not_active Expired - Lifetime
- 2005-05-18 CA CA2772033A patent/CA2772033C/en not_active Expired - Lifetime
- 2005-05-18 CA CA2771940A patent/CA2771940C/en not_active Expired - Lifetime
- 2005-05-18 CN CNA2005800243835A patent/CN101316627A/zh active Pending
- 2005-05-18 EP EP11184755.4A patent/EP2409732B1/en not_active Expired - Lifetime
- 2005-05-18 CA CA2771951A patent/CA2771951C/en not_active Expired - Lifetime
- 2005-05-18 CA CA2567023A patent/CA2567023C/en not_active Expired - Lifetime
- 2005-05-18 CA CA2771941A patent/CA2771941C/en not_active Expired - Lifetime
-
2006
- 2006-11-13 IL IL179241A patent/IL179241A/en active IP Right Grant
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002092015A2 (en) * | 2001-05-17 | 2002-11-21 | Genome Therapeutics Corporation | Reagents and methods for modulating dkk-mediated interactions |
| WO2003106657A2 (en) * | 2002-06-14 | 2003-12-24 | Stowers Institute For Medical Research | Wise/sost nucleic acid sequences and amino acid sequences |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008536816A (ja) * | 2005-03-18 | 2008-09-11 | エンゾー バイオケム，インコーポレイテッド | スクレロスチンおよびＷｎｔシグナル伝達ならびに骨形成の阻止阻害 |
| JP2010537950A (ja) * | 2006-11-14 | 2010-12-09 | エンゾー セラピューティクス， インコーポレイテッド | 骨形成および骨リモデリングのための組成物および方法 |
| KR101303941B1 (ko) | 2011-03-31 | 2013-09-05 | 연세대학교 산학협력단 | 피마자 추출물을 유효성분으로 함유하는 골 질환 예방 및 치료용 조성물 |
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| US20050196349A1 (en) | 2005-09-08 |
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| CA2771940A1 (en) | 2005-12-08 |
| IL179241A (en) | 2016-04-21 |
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| EP1758562A2 (en) | 2007-03-07 |
| WO2005115354A2 (en) | 2005-12-08 |
| CA2771941A1 (en) | 2005-12-08 |
| CA2772029C (en) | 2016-05-17 |
| EP1758562A4 (en) | 2009-07-22 |
| CA2567023C (en) | 2012-07-03 |
| EP1758562B1 (en) | 2012-12-05 |
| WO2005115354A3 (en) | 2007-09-13 |
| CA2772029A1 (en) | 2005-12-08 |
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| CA2771951A1 (en) | 2005-12-08 |
| EP2409732A1 (en) | 2012-01-25 |
| CA2771941C (en) | 2015-03-31 |
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