JP2008194110A - Blood sugar level computing method and instrument - Google Patents
Blood sugar level computing method and instrument Download PDFInfo
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- JP2008194110A JP2008194110A JP2007030051A JP2007030051A JP2008194110A JP 2008194110 A JP2008194110 A JP 2008194110A JP 2007030051 A JP2007030051 A JP 2007030051A JP 2007030051 A JP2007030051 A JP 2007030051A JP 2008194110 A JP2008194110 A JP 2008194110A
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Abstract
Description
本発明は、血糖値の算出方法及び装置に関するものである。 The present invention relates to a blood glucose level calculation method and apparatus.
血糖値は、糖尿病その他疾病の重要な指標であり、これを測定することは生体管理には必須のものである。この血糖値の測定は従来通り採血をし、その血液を調べて行なうものである。 The blood glucose level is an important indicator of diabetes and other diseases, and measuring it is essential for living body management. This blood sugar level is measured by collecting blood as usual and examining the blood.
この採血は注射器で行なうにしろ、採血具（ランセットと呼ばれている）を用いるにしろ、被検者に苦痛を与えるだけでなく、感染の不安、さらに術者の負担が常に伴う。更に、頻繁に行なう場合には血管および生体を損傷することも考えられる。 Whether this blood collection is performed with a syringe or a blood collection device (called a lancet), not only does the subject suffer pain, but there is always anxiety of infection and a burden on the operator. In addition, blood vessels and living bodies may be damaged when frequently performed.
よって、被検者に苦痛を与えず、感染の不安、さらに術者の負担がなく、且つ生体を損傷しない血糖値測定方法を提供する。 Therefore, a blood glucose measurement method is provided that does not give pain to the subject, does not cause anxiety about infection, does not burden the operator, and does not damage the living body.
このような現状に鑑み、本発明者は鋭意研究の結果本発明血糖値の算出方法及び装置を完成したものであり、その特徴とするところは、算出方法にあっては、血管が見える部位に光を照射し、その照射のエネルギーに起因して血液成分が発光する発光量を検知し、その発光量と、過去の検査データとから血糖値を算出する点にあり、算出装置にあっては、血管が見える部位に光を照射し、その照射のエネルギーに起因して血液成分が発光する発光量を検知し、その発光量と、過去の検査データとから血糖値を算出する装置であって、発光部、受光部、及び演算部を有する点にある。 In view of such a current situation, the present inventor has completed the calculation method and apparatus for blood glucose level of the present invention as a result of intensive research, and the feature thereof is that the blood vessel can be seen in the calculation method. In the point of calculating the blood sugar level from the amount of light emission and past test data, the amount of light emitted from the blood component is detected by irradiating light, and the blood component emits light due to the energy of the irradiation. An apparatus for irradiating a region where blood vessels can be seen, detecting the amount of light emitted by blood components due to the energy of the irradiation, and calculating the blood glucose level from the amount of light emitted and past test data , A light emitting unit, a light receiving unit, and a calculation unit.
まず本発明方法の原理について説明する。
血中グルコースは、その官能基−ＣＨＯとタンパク質又はアミノ酸の−ＮＨ2 残基とが非酵素的に縮合脱水することが知られている。この反応は化学的にはSchiff塩基の形成である。
このプロセスは糖尿病の合併症への初期進展の初期段階とも考えられるものである。そして、実際には糖尿病の診断にはＨｂＡ１ｃが用いられるが、これはヘモグロビン（タンパク質）のリジン末端の−ＮＨ2 とグルコースの−ＣＨＯとの脱水反応で−Ｃ＝Ｎ−結合を経て、転移後安定型のＨｂＡ１ｃとなったものである。
First, the principle of the method of the present invention will be described.
It is known that blood glucose has a non-enzymatic condensation dehydration of its functional group —CHO and a protein or amino acid —NH 2 residue. This reaction is chemically the formation of a Schiff base.
This process can also be considered as an early stage of early progress to diabetic complications. Actually, HbA1c is used for diagnosis of diabetes, which is a dehydration reaction between —NH 2 at the lysine end of hemoglobin (protein) and —CHO of glucose, via a —C═N— bond, and after metastasis. This is a stable HbA1c.
本発明者は、このSchiff塩基が他の二重結合と共役するときに蛍光を発することに着目し、更にこの強度が血中グルコース濃度に比例することから、血糖値を求めようとするものである。 The inventor of the present invention pays attention to the fact that this Schiff base emits fluorescence when it is conjugated with other double bonds, and further, since this intensity is proportional to the blood glucose concentration, it is intended to determine the blood glucose level. is there.
まず、所定の部位（例えば、左手手首内側、左手人差指内側等）に光を照射する。その光がタンパク分子に吸収され、そのエネルギーによって励起され蛍光が発せられる。この蛍光（発光）を受光器によって受光し定量する。即ち、照射した光がそのまま反射されたり、透過されて受光器に達するのではなく、分子がエネルギーを吸収し新たに別の光（波長の異なる）を発するのである。 First, light is irradiated to a predetermined part (for example, the left wrist inner side, the left index finger inner side, etc.). The light is absorbed by protein molecules and excited by the energy to emit fluorescence. This fluorescence (emission) is received by a light receiver and quantified. In other words, the irradiated light is not reflected or transmitted as it is, but reaches the light receiver, but the molecule absorbs energy and newly emits another light (having a different wavelength).
この時の血糖値を採血して従来の方法で測定する。そして、前記定量した受光量と血糖値との関係を求めておく。より厳密に行なうには、時刻や日を変えて複数回行ってグラフを求めてもよい。 The blood glucose level at this time is collected and measured by a conventional method. Then, the relationship between the quantified amount of received light and the blood glucose level is obtained. In order to perform it more strictly, the graph may be obtained by changing the time and date several times.
これで、その特定部位に特定の光を照射し、そこからの発光量を測定すれば、その発光量（受光量）に一定の係数を掛けるか、グラフ化したものと比較すれば血糖値が決定できる。 By irradiating specific light to the specific part and measuring the amount of light emitted from it, the amount of light emitted (the amount of received light) is multiplied by a certain coefficient, or the blood glucose level is compared with the graphed one. Can be determined.
次に本発明装置について説明する。
本発明装置は上記の算出方法に使用する装置であって、発光部、受光部、及び演算部を有するものである。
発光部とは、通常の発光装置でよく特別なものである必要はない。発する光は全光でも特定波長のものでもよい。即ち、上記した分子が吸収する波長付近のものだけでもよい。これは、２００〜４５０ｎｍ程度である。
Next, the device of the present invention will be described.
The device of the present invention is a device used in the above calculation method, and has a light emitting unit, a light receiving unit, and a calculation unit.
The light emitting unit may be a normal light emitting device and need not be special. The emitted light may be all light or a specific wavelength. In other words, only those in the vicinity of the wavelength absorbed by the molecule described above may be used. This is about 200 to 450 nm.
受光部も通常のものでよく市販されているものでもよい。
演算部とは、コンピューター部分であり、通常のコンピューター、ＣＰＵ等でよい。
The light receiving unit may be a normal one and may be commercially available.
The arithmetic unit is a computer part, and may be a normal computer, CPU, or the like.
更に、測定値や計算値を記憶するメモリー、ディスプレー、アウトプットするプリンター、入力キー等を設けてもよい。 Further, a memory for storing measured values and calculated values, a display, a printer for output, an input key, and the like may be provided.
本発明方法及び装置では、血糖値が非侵襲に且つ簡単、迅速に測定できるため、連続的な測定に最適である。例えば、
１ 糖尿病患者の手術時、手術後
２ 糖尿病患者の妊娠時の管理、妊娠糖尿病の管理
３ 小児発症糖尿病患者の思春期の管理
４ 高齢者の糖尿病管理
５ 糖尿病患者の運動時
６ 不安定型の糖尿病モニター
等である。
The method and apparatus of the present invention are optimal for continuous measurement because blood glucose levels can be measured non-invasively, easily and quickly. For example,
1 During and after surgery for diabetic patients 2 During pregnancy management of diabetic patients, management of gestational diabetes 3 Adolescent management of diabetic patients with diabetes 4 Diabetes management of elderly 5 During exercise of diabetic patients 6 Unstable diabetes monitor Etc.
また、簡単に継続測定（例えば、１時間ごとの測定等）ができるため、通常健康診断等で行なわれる空腹時血糖値の測定だけでは分からない糖尿病の発見が可能である。 In addition, since continuous measurement can be easily performed (for example, measurement every hour), it is possible to find diabetes that cannot be found only by measuring fasting blood glucose levels usually performed in a health checkup or the like.
以下実施例に従って本発明をより詳細に説明する。 Hereinafter, the present invention will be described in more detail with reference to examples.
ヘモグロビンと糖（グルコース）との反応物を調べるため、同じ結合様式、即ち反応によって共役の二重結合を生じるものとして、アルギニンとグルコースを用いた。
即ち、アルギニンのみを試験管に入れ、それに光を照射し、試験管からの発光量を調べた。同じことをグルコースのみでも行なった。この両者では、ほとんど発光はなかった。
In order to investigate the reaction product of hemoglobin and sugar (glucose), arginine and glucose were used as the same binding mode, that is, a reaction yielding a conjugated double bond.
That is, only arginine was put in a test tube, irradiated with light, and the amount of light emitted from the test tube was examined. The same was done with glucose alone. In both cases, there was almost no light emission.
次に、アルギニンとグルコースを混合して同様に光を照射すると、前記の測定と比較して多量の波長４５０ｎｍ付近の光を発した。
よって、アルギニンとグルコースの反応物が発光することが分かった。
Next, when arginine and glucose were mixed and irradiated in the same manner, a large amount of light having a wavelength of about 450 nm was emitted as compared with the above measurement.
Therefore, it was found that the reaction product of arginine and glucose emits light.
次にこの発光量とグルコース濃度（表ではグルコースとアルギニンとの合計の濃度）の相関関係を調べた。
グルコース濃度 発光量
１ ５ｇ／ｄｌ １．４
２ １０ｇ／ｄｌ ３．０
３ １５ｇ／ｄｌ ４．５
４ ２０ｇ／ｄｌ ５．９
Next, the correlation between the amount of luminescence and the glucose concentration (total concentration of glucose and arginine in the table) was examined.
Glucose concentration Amount of luminescence 15 g / dl 1.4
2 10 g / dl 3.0
3 15 g / dl 4.5
4 20 g / dl 5.9
この測定から、発光量と濃度とはほぼ比例関係があることが分かる。即ち、未知濃度のアルギニンとグルコースを含む溶液に光を照射し、発光量を測定し、その発光量が９なら濃度は３０ｇ／ｄｌであると推定できる。 From this measurement, it can be seen that the amount of luminescence and the density are almost proportional. That is, a solution containing arginine and glucose of unknown concentrations is irradiated with light, and the amount of luminescence is measured. If the amount of luminescence is 9, it can be estimated that the concentration is 30 g / dl.
これらの結果から、人体の血糖値も同様に測定、算定できることは容易に理解できる。
From these results, it can be easily understood that the blood glucose level of the human body can be similarly measured and calculated.
Claims (2)
A device that irradiates light where a blood vessel can be seen, detects the amount of light emitted by blood components due to the energy of the irradiation, and calculates the blood sugar level from the amount of light emitted and past blood glucose test data A blood glucose level calculating device comprising: a light emitting unit; a light receiving unit; and a computing unit.
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| JP2007030051A JP2008194110A (en) | 2007-02-09 | 2007-02-09 | Blood sugar level computing method and instrument |
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| JP2007030051A JP2008194110A (en) | 2007-02-09 | 2007-02-09 | Blood sugar level computing method and instrument |
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| JP2008194110A true JP2008194110A (en) | 2008-08-28 |
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| JP2007030051A Pending JP2008194110A (en) | 2007-02-09 | 2007-02-09 | Blood sugar level computing method and instrument |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010246578A (en) * | 2009-04-10 | 2010-11-04 | Utsunomiya Univ | Examination method and examination device for blood cholesterol |
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2007
- 2007-02-09 JP JP2007030051A patent/JP2008194110A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010246578A (en) * | 2009-04-10 | 2010-11-04 | Utsunomiya Univ | Examination method and examination device for blood cholesterol |
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