JP2008180641A - Dispenser, autoanalyzer and on-off member - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a dispenser capable of accurately dispensing a liquid, an autoanalyzer and an on-off member. <P>SOLUTION: The dispenser is equipped with a pipeline 5 (first pipeline) for connecting a liquid holding syringe 4 and a liquid discharge nozzle 2, a pipeline 7 (second pipeline) for connecting the pipeline 5 and a pressure sensor 61 for measuring the pressure in the pipeline 5 and the valve 8 (on-off means) provided on the joint of the pipeline 5 and the pipeline 7 not only to hold the pipeline 5 to an open state but also to perform the on-off operation of the pipeline 5 and the pipeline 7. A valve 8 closes the communication of the pipelines 5 and 7 when the liquid is discharged to the outside by the nozzle 2. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a dispensing device that dispenses a liquid, an automatic analyzer that includes the dispensing device and analyzes a specimen sample, and an opening / closing body.

  Conventionally, in a dispensing device that sucks and discharges a predetermined amount of liquid, as a technique for detecting an abnormality during dispensing, a pipe branched from a main pipeline that connects a syringe that holds the liquid and a nozzle that discharges the liquid A technique for providing a pressure sensor on a road is known (see, for example, Patent Document 1).

  In the above-described technique, when a piezoelectric element type pressure sensor is applied, there is a problem that the volume of liquid to be dispensed fluctuates due to a change in volume due to deformation of the piezoelectric element in accordance with pressure fluctuation at the time of dispensing. It was. As a technique for solving this problem, a technique is known in which an electromagnetic valve is provided between a pipe branching from a main pipe and a pressure sensor (see, for example, Patent Document 2).

JP 2002-333449 A Japanese Patent No. 3339177

  However, the technique described in Patent Document 1 has a problem in that when the amount of liquid to be ejected is very small, the pressure sensor portion becomes a dead volume and an accurate amount cannot be ejected. In addition, the pipe portion branched from the main pipe line may be deformed to cause a volume fluctuation, and such a volume fluctuation also hinders accurate liquid ejection.

  On the other hand, in the technique described in Patent Document 2, since the electromagnetic valve is closed when liquid is discharged, the problem of dead volume in the pressure sensor portion is solved. However, the electromagnetic valve branches off from the main pipeline. The problem of the volume fluctuation of the connected portion has not been solved yet, and has been an obstacle to accurately discharging the liquid.

  This invention is made | formed in view of the above, Comprising: It aims at providing the dispensing apparatus, automatic analyzer, and opening-closing body which can perform the dispensing of a liquid correctly.

  In order to solve the above-described problems and achieve the object, a dispensing apparatus according to the present invention includes a first pipe line connected to a syringe that holds a liquid in the dispensing apparatus that dispenses a small amount of liquid. A second pipe that connects the first pipe and a pressure sensor that measures the pressure in the pipe; and the first pipe and the first pipe and the second pipe An opening / closing means that is provided in the connection portion and maintains the first pipeline in an open state, and opens and closes between the first pipeline and the second pipeline. And

  The “trace amount” in the present invention is preferably an amount less than 1 μL.

  In the dispensing device according to the present invention as set forth in the invention described above, the first conduit is a conduit connecting the syringe and a nozzle for discharging a liquid.

  In the dispensing device according to the present invention as set forth in the invention described above, the first conduit is a conduit for supplying a cleaning liquid for cleaning a nozzle for discharging a liquid to the syringe.

  The dispensing device according to the present invention is the dispensing device according to the above invention, wherein the opening / closing means is disposed between the first pipe line and the second pipe line when the nozzle discharges a predetermined amount of liquid to the outside. It is characterized by closing.

  In the dispensing device according to the present invention, in the above invention, when the opening and closing means cleans the inside of the nozzle or sucks liquid from the nozzle, the first conduit and the second tube It is characterized by opening between the road.

  An automatic analyzer according to the present invention includes a sample dispensing unit that dispenses a sample and a reagent dispensing unit that dispenses a reagent, and reacts the sample with the reagent to remove the components of the sample. An automatic analyzer for analysis, wherein the specimen dispensing unit or the reagent dispensing unit is configured using the dispensing device described in any one of the above inventions.

  The opening / closing body according to the present invention is provided at a connection portion between the first pipeline and a pipeline different from the first pipeline, and maintains the first pipeline in an open state. Opening and closing between one pipe line and the second pipe line is characterized.

  According to the present invention, the first pipe connected to the syringe holding the liquid, the second pipe connecting the first pipe and the pressure sensor for measuring the pressure in the pipe, Provided on one pipe line or at a connection portion between the first and second pipe lines, and maintains the first pipe line in an open state, and opens and closes between the first pipe line and the second pipe line. By providing the opening / closing means to perform, an accurate amount of liquid can be discharged without being affected by the dead volume of the pressure sensor portion or the deformation of the conduit portion filled with the pressure transmission liquid.

  The best mode for carrying out the present invention (hereinafter referred to as “embodiment”) will be described below with reference to the accompanying drawings. Note that the drawings referred to in the following description are merely schematic, and when the same object is shown in different drawings, dimensions, scales, and the like may be different.

(Embodiment 1)
FIG. 1 is a diagram showing a configuration of a dispensing apparatus according to Embodiment 1 of the present invention. The dispensing apparatus 1 shown in FIG. 1 has a thin tubular nozzle 2 that directly sucks or discharges a liquid to be dispensed, and causes the nozzle 2 to perform a vertical movement operation and a horizontal rotation operation. The nozzle transfer part 3 to be transferred, and the liquid to be dispensed from the nozzle 2 are sucked or discharged, and the suction and discharge operation of the cleaning liquid Wa that is a pressure transmission liquid that transmits pressure to the nozzle 2 and is a cleaning liquid for the nozzle 2 is performed. And a syringe 4 to be performed. The nozzle 2 and the syringe 4 are connected via a conduit 5 (first conduit) that forms a flow path of the cleaning liquid Wa.

  In addition, the dispensing device 1 includes a pressure detection unit 6 that detects the pressure inside the pipe 5. The pressure detection unit 6 is connected to a pipe line 7 (second pipe line) that is branched from the pipe line 5. A valve 8 that opens and closes between the pipe line 5 and the pipe line 7 is provided at a connection portion with the pipe line 7 on the pipe line 5 while maintaining the open state of the pipe line 5.

  FIG. 2 is a partially enlarged view showing a cross-sectional shape of the valve 8 that is the opening / closing body according to the first embodiment and a configuration in the vicinity of the valve 8. The valve 8 includes a connecting portion 81 having a spherical shell shape, and a rotating portion 82 that is provided inside the connecting portion 81 and is rotatable about a predetermined axis. The rotating part 82 has a spherical shape arranged concentrically with the spherical shell of the connecting part 81, and a single axis passing through the center of the sphere is a rotating axis.

  The connecting portion 81 has two openings 811 that are penetrated in the direction of the rotation axis of the rotation portion 82, and an opening 812 that passes through the center of the rotation portion 82 and penetrates in the direction intersecting with the rotation axis of the rotation portion 82. . The opening 811 is connected to the pipeline 5, while the opening 812 is connected to the pipeline 7. In addition, since the connection aspect of the connection part 81 and the pipe line 5 or the pipe line 7 is the same as the connection aspect of the conventional valve and a pipe line, it has simplified and described in FIG.1 and FIG.2. This is the same for the other drawings.

  The rotating part 82 has a through-passage 821 that passes through the rotation axis, and a branching path 822 that branches from the center of the through-passage 821 in a direction intersecting the through-passage 821 and extends to the surface of the rotating part 82. The rotation is controlled by a control unit 9 configured using a CPU or the like. The through passage 821 is always in communication with the opening 811. Further, the branch path 822 can communicate with the opening 812 in accordance with the stationary position of the rotating unit 82.

  In FIG. 2, the pipe line 5 and the pipe line 7 communicate with each other by sequentially passing through an opening 811, a through path 821, a branch path 822, and an opening 812. In this sense, the state shown in FIG. 2 is a state in which the valve 8 is opened.

  FIG. 3 is a diagram illustrating a state in which the valve 8 is closed by rotating the rotating unit 82 from the state illustrated in FIG. 2. In FIG. 3, the opening 812 of the connecting portion 81 is shielded by the surface of the rotating portion 82, and the conduit 5 and the conduit 7 are not in communication.

  Next, the configuration of the dispensing apparatus 1 will be described. The syringe 4 has a cylinder 4a and a plunger 4b, and the plunger 4b slides in the cylinder 4a in the vertical direction in FIG. Generate pressure to be transmitted.

  The plunger drive unit 10 is configured using, for example, a linear motor and has a function of driving the plunger 4b at a high speed. In the first embodiment, it is assumed that the dispensing device 1 dispenses a small amount of liquid smaller than 1 μL.

  In a small amount of dispensing where the moving distance of the plunger 4b is minute, the speed of the liquid that separates from the opening end of the nozzle 2 is important in order to reliably discharge the liquid to be dispensed. That is, in order to discharge the liquid to be dispensed against the surface tension of the liquid surface at the opening end of the nozzle 2 and the viscous resistance of the inner wall of the nozzle 2, the initial velocity of the liquid at the start of discharge is particularly important. In addition, it has become clear from experiments that it is necessary to complete the operation of entering the plunger 4b into the cylinder 4a, which is necessary for discharging the liquid, within 40 msec. Therefore, it is desirable that the plunger drive unit 10 has a function of performing a drive capable of completing the entry operation of the plunger 4b into the cylinder 4a within 40 msec.

  The syringe 4 is also connected to a pipe line 11 different from the pipe line 5. This pipe line 11 reaches the tank 12 that stores the cleaning liquid Wa, and in the middle of this, the solenoid valve 13 that adjusts the flow rate of the cleaning liquid Wa and the pump 14 that sucks the cleaning liquid Wa from the side close to the syringe 4. Are provided sequentially. As the pressure transmission cleaning liquid Wa stored in the tank 12, an incompressible fluid such as ion exchange water, distilled water, deaerated water, reverse osmosis membrane dropping water or the like is applied.

  The pressure detection unit 6 is connected to the pipe line 5 via the valve 8, detects a pressure change of the cleaning liquid Wa filled in the pipe line 5, and converts the pressure sensor 61 into an electric signal. And a signal processing circuit 62 that performs signal processing such as amplification and A / D conversion on the output electric signal. The installation position of the pressure detection unit 6 on the pipeline 5 can be changed as appropriate depending on conditions such as the sensitivity of the pressure sensor 61.

  When the dispensing apparatus 1 having the above configuration sucks the liquid to be dispensed (including the case where a slight solid component is contained in the liquid), the pipes 5, 7, and 11 are filled with the cleaning liquid Wa. Thereafter, with the valve 8 opened and the electromagnetic valve 13 closed, the plunger 4b is retracted to suck the liquid. At this time, the pressure sensor 61 detects a pressure fluctuation in the pipe 5. Thereafter, the valve 8 is closed and the plunger 4b is advanced to discharge a predetermined amount of liquid from the nozzle 2 to the outside. The amount of movement of the plunger 4b is determined according to the amount of liquid sucked and discharged.

  According to the dispensing apparatus 1 described above, when the liquid is discharged, the rotating part 82 of the valve 8 is rotated to shield the pipe line 7, thereby being influenced by the pressure sensor 61 and the dead volume of the pipe line 7. So that the exact amount of liquid can be dispensed. Further, since the valve 8 is provided at the connection portion between the pipe line 5 and the pipe line 7 on the pipe line 5, the length of the pipe line 7 connected to the nozzle 2 when the liquid is discharged can be minimized. The influence on the discharge amount due to the deformation of can be minimized.

  The dispensing apparatus 1 according to the first embodiment can be applied to an automatic analyzer that analyzes a component of a specimen by reacting the specimen with a reagent. FIG. 4 is an explanatory diagram showing the configuration of the main part of the automatic analyzer equipped with the dispensing device 1. The automatic analyzer 100 shown in FIG. 1 dispenses a specimen (sample) such as blood or body fluid and a reagent corresponding to the test item of the specimen into predetermined reaction containers, respectively, and converts the reaction liquid in the reaction container. A measurement unit 101 that performs optical measurement, and a data processing unit 201 that controls the automatic analyzer 100 including the measurement unit 101 and analyzes the measurement result in the measurement unit 101, and these two units. Is a device that automatically and continuously performs biochemical analysis of a plurality of specimens by cooperating with each other.

  The measurement unit 101 reacts the sample and the reagent with the sample transport unit 102 that sequentially transports the plurality of racks 112 that hold the sample containers 111 in which the sample is stored, the reagent container holding unit 103 that holds the reagent containers 121, and the like. And a reaction container holding unit 104 that holds the reaction container 131. Further, the measurement unit 101 is accommodated in a sample dispensing unit 105 that dispenses a sample accommodated in the sample container 111 on the sample transfer unit 102 into the reaction container 131 and a reagent container 121 on the reagent container holding unit 103. Reagent dispensing unit 106 that dispenses a reagent into reaction vessel 131, agitation unit 107 that agitates the liquid contained in reaction vessel 131, and light that has been irradiated from a light source and passed through reaction vessel 131 is received. And a reaction vessel cleaning unit 109 that cleans the reaction vessel 131 on the reaction vessel holding unit 104 using a cleaning liquid.

  The reagent container holding part 103 and the reaction container holding part 104 are attached to the wheel for accommodating and holding the reagent container 121 and the reaction container 131, respectively, and the center of the bottom surface of the wheel, and the wheel is rotated about a vertical line passing through the center as a rotation axis. Driving means (not shown). The inside of each container holding part is kept at a preset temperature. When performing biochemical analysis, since two types of reagents are often used for one specimen, the reagent container holding unit 103 for the first reagent and the reagent container holding unit for the second reagent 103 may be provided separately, and a reagent dispensing unit 106 corresponding to each reagent container holding unit 103 may be provided separately.

  The sample dispensing unit 105 and the reagent dispensing unit 106 are configured by the dispensing apparatus 1 according to the first embodiment. Among these, since the sample is often dispensed in a smaller amount, at least the sample dispensing unit 105 is preferably configured by the dispensing device 1.

  By the way, in FIG. 4, since the main purpose is to schematically show the main components of the measurement unit 101, the positional relationship between the components is not always accurate. The positional relationship between the accurate components of the measurement unit 101 is determined according to various conditions such as the number of reagent container holding parts 103 and the rotation mode of the wheel of the reaction container holding part 104 in the interval of the dispensing operation.

  Next, the configuration of the data processing unit 201 will be described. The data processing unit 201 is realized by a computer having a CPU, a ROM, a RAM, and the like. The data processing unit 201 includes a rod-shaped member board, a mouse, and the like. The input unit 202 receives input of information necessary for sample analysis, information including an operation instruction signal of the automatic analyzer 100, and a display such as a liquid crystal display. An output unit 203 having an apparatus for displaying and outputting information relating to sample analysis, a control unit 204 for controlling each function or means of the automatic analyzer 100, and a memory for storing various types of information relating to sample analysis Unit 205.

  The control unit 204 includes a calculation unit 241 that performs analysis calculation based on the measurement result of the measurement unit 101 and generates analysis data of the sample. The calculation unit 241 performs a calculation for converting the absorbance measured by the photometry unit 108 into a concentration by using a calibration curve stored in the storage unit 205 as a specific analysis calculation. The control unit 204 also has the function of the control unit 9 of the dispensing apparatus 1 applied as the sample dispensing unit 105 and the reagent dispensing unit 106.

  According to the automatic analyzer 100 having the above configuration, since the dispensing device 1 according to the present embodiment is provided as the sample dispensing unit 105 and the reagent dispensing unit 106, high-precision dispensing for a very small amount of sample or reagent. Can be realized.

  According to the first embodiment of the present invention described above, the first conduit connected to the syringe that holds the liquid is connected to the pressure sensor that measures the pressure in the first conduit. The first pipeline is provided at the connection between the second pipeline and the first pipeline or between the first pipeline and the second pipeline, and maintains the first pipeline in an open state. By providing a valve (opening / closing means) that opens and closes between the first pipe and the second pipe, liquid can be accurately dispensed. Especially this Embodiment 1 has a big effect when dispensing a trace amount liquid.

  Further, according to the first embodiment, by providing the valve at the connection portion between the first pipe line and the second pipe line, the length of the pipe line connected to the nozzle when the liquid is discharged is minimized. And the influence of the deformation of the pipe line can be minimized.

  FIG. 5 is a diagram showing a configuration of a dispensing apparatus according to a modification of the first embodiment. In the dispensing device 20 shown in the figure, the valve 8 is provided in a pipe line 16 (first pipe line) that connects the electromagnetic valve 13 and the syringe 4. The valve 8 is not interposed in the pipe line 15 connecting the nozzle 2 and the syringe 4. The configuration of the dispensing device 20 excluding this point is the same as the configuration of the dispensing device 1 described above, and the obtained effects are also the same.

(Embodiment 2)
FIG. 6 is a perspective view showing a configuration of a valve provided in the dispensing device according to Embodiment 2 of the present invention. FIG. 7 is a cross-sectional view taken along line AA in FIG. The valve 31 (opening / closing body) shown in these drawings has a cylindrical connecting portion 32 and a hollow cylindrical shape that covers a part of the side surface of the connecting portion 32, and is connected under the control of the control portion 9. The movable portion 33 is movable up and down with respect to the longitudinal direction of 32.

  The connecting portion 32 includes a through passage 321 that penetrates along the central axis of the rotation shaft, and a branch passage 322 that branches from the through passage 321 and that has an opening surface on the side surface facing the movable portion 33. Both ends of the through passage 321 are connected so as to communicate with the conduit 5.

  The movable portion 33 has an opening 331 that is penetrated in a direction orthogonal to the moving direction, that is, a direction orthogonal to the through passage 321, and is connected so as to be able to communicate with the conduit 7.

  In FIG. 7, the pipe line 5 and the pipe line 7 communicate with each other by sequentially passing through a through path 321, a branch path 322, and an opening 331. In this sense, the state shown in FIG. 7 is a state in which the valve 31 is opened.

  FIG. 8 is a cross-sectional view showing a state in which the valve 31 is closed by moving the movable portion 33 along the longitudinal direction of the pipe line 5 from the state shown in FIG. In FIG. 8, the opening 331 of the movable portion 33 is shielded by the side surface of the connecting portion 32, and the pipe line 5 and the pipe line 7 are not in communication. In the state shown in FIG. 8, the branch path 322 connecting the pipe line 5 and the pipe line 7 becomes a dead volume. Almost no need to occur.

  Instead of moving the movable portion 33 along the longitudinal direction of the connection portion 32, the movable portion 33 may be rotated around the connection portion 32.

  The dispensing apparatus according to the second embodiment has the same configuration as the dispensing apparatus 1 according to the first embodiment, except for the configuration of the valve 31 that is an opening / closing means. Therefore, according to the dispensing apparatus according to the second embodiment, as in the first embodiment, the liquid is not affected by the dead volume of the pressure sensor portion or the deformation of the pipe portion filled with the pressure transmission liquid. Can be accurately dispensed.

  Note that the dispensing apparatus according to the second embodiment can also be applied to the sample dispensing part and the reagent dispensing part of the automatic analyzer.

(Embodiment 3)
FIG. 9 is a cross-sectional view showing a configuration of a valve included in the dispensing device according to Embodiment 3 of the present invention. The valve 41 (opening / closing body) shown in the figure has a configuration in which a metal bar-like member (key) is advanced and retracted by an electromagnet so that the pipe 5 and the pipe 7 can be opened and closed. ing. Specifically, the valve 41 has a connection part 42 that connects the pipe line 5 and the pipe line 7, and a tip end that can be fitted to the connection part 42. And a holding part 44 that is attached to the connection part 42 and holds the proximal end side of the bar-like member 43, and controls the advancing and retreating operation of the bar-like member 43 by a built-in electromagnet.

  The connection portion 42 has a hole portion 421 that allows the pipe line 5 and the pipe line 7 to communicate with each other. Of the end portions of the hole portion 421, the vicinity of the end portion where the rod-shaped member 43 slides facing the holding portion 44. Is provided with a seal member 45 for preventing liquid leakage from the pipes 5 and 7.

  A flange portion 43 a protruding in the radial direction is formed at a substantially central portion in the longitudinal direction of the rod-shaped member 43. Moreover, the front-end | tip part contact | abutted to the opening surface of the pipe line 5 which advances / retreats in the hole 421 of the rod-shaped member 43 has a tapered shape. By forming the tip of the rod-shaped member 43 in a tapered shape, the area of the opening formed on the side surface of the pipeline 5 can be reduced, and the durability of the pipeline 5 can be ensured.

  The holding portion 44 has a spring 46 that abuts on the base end portion of the rod-shaped member 43 and urges the rod-shaped member 43 in the longitudinal direction thereof, and an electromagnet 47 that causes the rod-shaped member 43 to advance and retract by switching energization. Further, the holding portion 44 is formed with a hole portion 441 for moving the rod-like member 43 forward and backward in the holding portion 44. The hole portion 441 has a stepped hole shape composed of a large-diameter portion having substantially the same diameter as the flange portion 43a, a coaxial portion with the large-diameter portion, and a small-diameter portion having substantially the same diameter as the other portions of the rod-shaped member 43. And communicates with the hole 421 of the connecting portion 42. The large diameter portion of the hole portion 441 has a function of preventing the flange portion 43a from coming off. The electromagnet 47 is configured by winding a coil around a core made of a magnetic material such as iron.

  FIG. 9 shows a non-energized state in which no current flows through the electromagnet 47. In this non-energized state, the tip of the rod-shaped member 43 reaches the boundary surface between the pipe line 5 and the connecting portion 42. For this reason, in the non-energized state shown in FIG. 9, between the pipe line 5 and the pipe line 7 is shielded, and the valve 41 is closed. As is clear from FIG. 9, since the dead volume does not exist at the branching portion from the pipe line 5 with the valve 41 closed, the liquid to be dispensed can be accurately discharged.

  When an electric current is passed through the electromagnet 47, the rod-shaped member 43 is attracted by the electromagnet 47 and moves from the position shown in FIG. 9 to the base end side (right side in the figure), resulting in the state shown in FIG. Therefore, in the energized state shown in FIG. 10, the pipe line 5 and the pipe line 7 communicate with each other, and the valve 41 is opened.

  The dispensing apparatus according to the third embodiment has the same configuration as the dispensing apparatus 1 according to the first embodiment, except for the configuration of the valve 41 that is an opening / closing means. Therefore, according to the dispensing apparatus according to the third embodiment, as in the first embodiment, the liquid is not affected by the dead volume of the pressure sensor portion or the deformation of the pipe portion filled with the pressure transmission liquid. Can be accurately dispensed.

  Also in the third embodiment, the dispensing device provided with the opening / closing means described above can be applied to the sample dispensing unit and the reagent dispensing unit of the automatic analyzer.

  Moreover, in this Embodiment 3, it can also be set as the structure which closes a valve in an energized state by changing the positional relationship of the electromagnet in a holding | maintenance part, a spring, and the flange part of a rod-shaped member.

  FIG. 11 is a diagram illustrating a configuration of a valve included in a dispensing device according to a modification of the third embodiment. The valve 51 (opening / closing body) shown in the figure has a connecting part 52 for connecting the pipe line 5 and the pipe line 7, and a tip end can be fitted to the connecting part 52, and the pipe line 5 and the pipe line 7 are moved forward and backward. A rod-shaped member 53 that defines an open / closed state of the rod-shaped member, a holding portion (not shown) that is attached to the connecting portion 52 and holds the proximal end side of the rod-shaped member 53 and controls the advance / retreat operation of the rod-shaped member by a built-in electromagnet; Is provided.

  The configuration of the base end portion of the rod-shaped member 53 (including the flange portion) and the configuration of the holding portion are the same as the configuration of the rod-shaped member 43 of the valve 41 and the configuration of the holding portion 44, respectively. In this sense, FIG. 11 shows an energized state.

  In this modification, the advancing / retreating direction of the rod-shaped member 53 is parallel to the pipe line 5, and is orthogonal to the pipe line 7. For this reason, it is not necessary to taper the front-end | tip part of the rod-shaped member 53, and the rod-shaped member 53 has comprised the cylindrical shape except the flange part.

  So far, the first to third embodiments have been described in detail as the best mode for carrying out the present invention, but the present invention should not be limited only by these embodiments. That is, the present invention can include various embodiments and the like not described herein, and various design changes and the like can be made without departing from the technical idea specified by the claims. Is possible.

It is a figure which shows the structure of the dispensing apparatus which concerns on Embodiment 1 of this invention. It is an enlarged view of the state which opened the valve. It is an enlarged view of the state which closed the valve. It is a figure which shows the structure of the main part of the automatic analyzer which concerns on Embodiment 1 of this invention. It is a figure which shows the structure of the dispensing apparatus which concerns on the modification of Embodiment 1 of this invention. It is a perspective view which shows the structure of the valve with which the dispensing apparatus which concerns on Embodiment 2 of this invention is provided. It is the sectional view on the AA line of FIG. It is sectional drawing which shows the state which moved the movable part from the state of FIG. It is a figure which shows the structure (at the time of non-energization) of the valve with which the dispensing apparatus which concerns on Embodiment 3 of this invention is provided. It is a figure which shows the structure (at the time of electricity supply) of the valve with which the dispensing apparatus which concerns on Embodiment 3 of this invention is provided. It is a figure which shows the structure of the valve with which the dispensing apparatus which concerns on the modification of Embodiment 3 of this invention is provided.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1,20 Dispensing apparatus 2 Nozzle 3 Nozzle transfer part 4 Syringe 4a Cylinder 4b Plunger 5, 7, 11, 15, 16 Pipe line 6 Pressure detection part 8, 31, 41, 51 Valve (opening-closing body)
DESCRIPTION OF SYMBOLS 9,204 Control part 10 Plunger drive part 12 Tank 13 Electromagnetic valve 14 Pump 32, 42, 52, 81 Connection part 33 Movable part 43,53 Rod-shaped member 43a Flange part 44 Holding part 45 Seal member 46 Spring 47 Electromagnet 61 Pressure sensor 62 Signal processing circuit 82 Rotating unit 100 Automatic analyzer 101 Measurement unit 102 Sample transfer unit 103 Sample container holding unit 104 Reaction container holding unit 105 Sample dispensing unit 106 Reagent dispensing unit 201 Data processing units 321, 821 Through path 322, 822 Branch 331, 811, 812 Opening 421, 441 Hole Wa Washing liquid

Claims (7)

In a dispensing device that dispenses a small amount of liquid,
A first conduit connected to a syringe holding the liquid;
A second pipe connecting the first pipe and a pressure sensor for measuring the pressure in the pipe;
Provided on the first pipeline or at the connection between the first pipeline and the second pipeline, and maintaining the first pipeline in an open state, and the first pipeline and the second pipeline Opening and closing means for opening and closing with the second pipe line;
A dispensing device characterized by comprising: The first conduit is
The dispensing apparatus according to claim 1, wherein the dispensing apparatus is a pipe line that connects the syringe and a nozzle that discharges a liquid. The first conduit is
The dispensing apparatus according to claim 1, wherein the dispensing apparatus is a conduit that supplies a cleaning liquid for cleaning a nozzle that discharges liquid to the syringe. The opening / closing means includes
4. The dispensing device according to claim 2, wherein when the nozzle discharges a predetermined amount of liquid to the outside, the nozzle closes between the first pipe and the second pipe. 5. The opening / closing means includes
4. The component according to claim 2, wherein when the inside of the nozzle is washed or a liquid is sucked from the nozzle, a gap is opened between the first pipeline and the second pipeline. 5. Note device. An automatic analyzer having a sample dispensing unit for dispensing a sample and a reagent dispensing unit for dispensing a reagent, and analyzing the components of the sample by reacting the sample with the reagent,
The automatic analyzer according to any one of claims 1 to 5, wherein the sample dispensing unit or the reagent dispensing unit is configured using the dispensing device according to any one of claims 1 to 5.   The first pipe and the second pipe different from the first pipe are provided at a connection portion, and the first pipe is maintained in an open state, and the first pipe and An opening / closing body that opens / closes with the second pipe line.

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