JP2008156275A - Enjoyment improver for preparation, and highly enjoyable preparation containing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an enjoyment improver for a preparation, improving the enjoyment at the use of the preparation by only adding the improver to various kinds of the preparations, and to provide a preparation obtained by adding the improver. <P>SOLUTION: A composition constituted of 16-androstene steroid and a powder is used as the enjoyment improver for the preparation. 4,16-Androstadien-3-one is preferable as the 16-androstene steroid, and a water-absorbing spherical powder is preferable as the powder. The highly enjoyable preparation having the enjoyment improved by the enjoyment improver contains 0.1-100 ppm of the 16-androstene steroid and 0.01-25 wt.% of the powder. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  In the present invention, a sensitization improver for preparations that can improve the sensitivities in use of various preparations by adding to various preparations including cosmetics, and the sensitization improver for preparations are added. It relates to the preparation.

  Conventionally, active ingredients according to purposes such as deodorization and skin care are blended in cosmetics, and perfumes are added. The main purpose of the perfume is to improve the impression (favorability) of the user from the other person, but at the same time, it is also intended to improve the user's feeling of use (favorability to use). Although this fragrance is a good impression for the user, it may not be preferred by others or vice versa. In addition, it is also considered that the use of perfume is reduced as much as possible or not used in body care products provided to sensitive users such as allergies.

  As described above, in the case where the fragrance for improving the feeling of use does not suit the taste or the product is not suitable for use, the use is inevitably avoided. In order to avoid such problems, conventionally, for example, a fragrance that is commonly preferred by all people has been developed, or recourse has been made to use one having a higher purity as an active ingredient for body care. In that case, development costs and manufacturing costs have to be high, and it has been difficult to provide inexpensive products.

  Conventionally, as a means for improving the favorable sensitivity of cosmetics, as described above, a fragrance was used, but 16-androstene steroid was added as a receptor binding steroid of nasal neuroepithelial cells, thereby A non-therapeutic fragrance composition that enhances the sensitivity of the user to a fragrance has been proposed (Patent Document 1).

Japanese Patent No. 3121016

  The non-therapeutic fragrance composition described in Patent Document 1 is a composition that enhances sensitivity to a user's fragrance by stimulating nasal neuroepithelial cells communicating with the hypothalamus of the brain, and is contained as a main component Depends on the improvement of the feeling of use by the fragrance. Therefore, as discussed above, if there is no preference for the fragrance used, it will be counterproductive, and it cannot be used in formulations that require reduced or no fragrance. The problem is still not solved.

  The demand to improve the sensitivities in use of products is not limited to cosmetics, but also laundry detergents, garment treatment agents, body cleaners, bathing agents, fabric products, leather products, chemical fiber products, plastic products It seems to be potentially in other preparations such as body clothing materials and accessory materials. However, the present situation is that no sensitization improver for preparations that can improve the sensitivities of such various preparations is provided.

  The present invention has been made in view of the above-described conventional circumstances, and the problem is that the sensitization improver for preparations that can improve the sensitivities in use of the preparations simply by adding to various preparations, and the The object is to provide a preparation to which an improver is added.

  In order to solve the above-mentioned problems, the present inventors have intensively conducted experiments and examinations, and have obtained the following knowledge. That is, (1) when a predetermined amount of 16-androstene steroid is added to various preparations, the sensitivities during and after use of the preparations are improved. (2) We have come to find out that the combination is not essential, and (3) the combination of the water-absorbing spherical powder gives a smooth touch and further improves the sensitivity to the preparation.

  In the present invention, the favorable sensitivity for use of the preparation means good feeling during use or after use, and in particular, a feeling such as a feeling of relief and excitement in addition to a feeling of smoothness and smoothness. It means the overall feeling of use including goodness.

  The present invention has been made based on the above findings. That is, the drug sensitivity improving agent according to the present invention is characterized by comprising 16-androstene steroid and powder. As the 16-androstene steroid to be used, 4,16-androstadien-3-one is preferable. Moreover, when adding the favorable agent for pharmaceutical preparations of this invention to various formulations, it is preferable to prepare so that the compounding quantity of 16-androstene steroid in various formulations may be 0.01-100 ppm. When the blending amount is less than 0.01 ppm, the effect of improving the favorable sensitivity of the preparation becomes insufficient. Moreover, when it exceeds 100 ppm, the favorable effect improvement effect of a formulation will peak and it will become uneconomical. The powder is preferably a water-absorbing spherical powder. Formulations include cosmetics, laundry detergents, clothing treatments, body cleaners, bathing agents, body clothing materials such as fabric products, leather products, chemical fiber products, plastic products, and accessory materials. Depending on the final product, known ingredients can be added. Examples of the additive component include surfactants, oils, alcohols, moisturizers, thickeners, preservatives, chelating agents, pH adjusters, fragrances, dyes, ultraviolet absorption / scattering agents, vitamins, and water. These can be appropriately blended as necessary.

  The sensitivity improver for pharmaceutical preparations according to the present invention can impart a favorable feeling of use (favorability) to the user of the pharmaceutical preparation by adding a predetermined amount to various pharmaceutical preparations. Since the combined use of the fragrance component is not essential, the degree of freedom of selection of the target preparation is great, and it can be applied to a wide range of preparations.

As described above, the sensitization improver for preparations according to the present invention is characterized by comprising 16-androstene steroid and powder.
Below, the 16-androstene steroid which is an active ingredient of the likability improver for preparations according to the present invention and the powder will be described individually.

  The 16-androstene steroid is a compound having a pheromone-like action, and specifically, mention may be made of 4,16-androstadien-3-one and 5,16-androstadien-3-ol. Can do. These have the effect of improving the sensitivity of using the preparation. In particular, 4,16-androstadien-3-one exhibits a high favorable sensitivity improvement effect.

  When the formulation preference improver of the present invention is added to various formulations, it is added so that the amount of 16-androstene steroid in each formulation is 0.01 to 100 ppm (0.01 μg / mL to 100 μg / mL). It is preferable to do. If the blending amount is less than 0.01 ppm, it is not possible to obtain the desired sensitivity improving effect of the preparation. On the other hand, if it exceeds 100 ppm, the effect of improving the favorable sensitivity reaches its peak, and the economic efficiency deteriorates. The blending amount of 16-androstene steroid in the product preference improver of the present invention may be in a range suitable for the amount of 16-androstene steroid in each preparation to be added to be in the above range, What is necessary is just to prepare according to the composition of each preparation made into object.

The following powders can be listed as examples of the powder that increases the favorable effect of the preparation when used in combination with the 16-androstene steroid.
Specific examples include inorganic powders such as silicic acid, silicic anhydride, magnesia-silica, titanium oxide, zirconium oxide, tantalum oxide, alumina, zeolite, silver-carrying zeolite, organic powders such as cellulose, hemp, silk, acrylic acid, Acrylic polymers derived from monomers such as acrylic acid ester, methacrylic acid, methacrylic acid ester, vinyl acetate, methyl vinyl ether, styrene, α-methylstyrene, divinylbenzene, ethylene glycol dimethacrylate, hexamethylenediamine, adipic acid, ε -Polymer compound powders derived from monomers such as caprolactam and silane, such as homopolymers and copolymers other than acrylic polymers. Among these, anhydrous silicic acid, magnesia-silica, and acrylic polymer are preferable, and anhydrous silicic acid is particularly preferable, and spherical secondary particles of anhydrous silicic acid are particularly preferably used.

  The powder of the present invention is preferably water-absorbing and is preferably a spherical powder. These can be used alone or in combination of two or more.

  Thus, in the present invention, inorganic powder such as nonporous silicic acid anhydride and porous silicic acid, organic powder, acrylic polymer, polymer polymer powder such as homopolymer and copolymer other than acrylic polymer, etc. By using at least one kind of powder in combination with 16-androstene steroid, it is possible to impart a more tactile sensation to the preparation and to further improve the sensitivity of the preparation. When the product preference improver of the present invention is added to various preparations, it is preferably 0.01 to 25% by weight, preferably 0.1 to 15% by weight, based on the total amount of the preparation. By setting it to the lower limit value or more, moisture absorption and moisture release effects can be obtained, and when it is set to the upper limit value or less, the feeling of use becomes particularly good. If the blending amount is less than 0.01% by weight, a suitable tactile sensation of the desired preparation cannot be obtained. On the other hand, if it exceeds 10% by weight, the effect of improving the favorable sensitivity will reach its peak and the economic efficiency will deteriorate. The blending amount of the water-absorbing spherical powder in the product preference improver of the present invention may be in a range suitable for the amount of water-absorbing spherical powder in each preparation to be added to be in the above range, What is necessary is just to prepare according to the composition of each preparation made into object.

  As the solvent for dissolving the 16-androstene steroid, any solvent can be used as long as it can be generally used. Among them, fatty acid esters are preferable.

  As the dispersant for dispersing the powder in the 16-androstene steroid solution, any dispersant can be used as long as it can be generally used. Particularly preferred examples of the dispersant include fatty acid esters. Among these, esters having a fatty acid chain tone of 10 to 12 are particularly preferable.

  Examples of the preparations to which the sensitization improver for preparations according to the present invention is added include, for example, cosmetics, laundry detergents, clothing treatment agents, body cleaners, bathing agents, cloth products, leather products, and chemical fibers. It can be used for body clothing materials and accessory materials such as products and plastic products, and known blending components can be added depending on the final product. Examples of the additive component include surfactants, oils, alcohols, moisturizers, thickeners, preservatives, chelating agents, pH adjusters, fragrances, dyes, ultraviolet absorption / scattering agents, vitamins, and water. These can be appropriately blended as necessary.

  Examples of the present invention will be described below. The following examples are only suitable examples for explaining the present invention, and do not limit the present invention.

(Examples 1 and 2 and Comparative Examples 1 and 2)
In Examples 1 and 2 and Comparative Examples 1 and 2 shown below, a preparation favorableness improver according to the present invention was prepared, and this preparation favorableness improver was commercially available as shown in Table 1 below. A predetermined amount was added to two types of cosmetics, and the sample before the addition and the sample after the addition were used by 20 female panelists, and the use sensitivity was answered by the following five-step evaluation. As commercially available female cosmetics, two types of female cosmetics (single fragrance and one fragrance) manufactured by Chifure Co., Ltd. were used.
(5-level evaluation)
5: Very good 4: Good 3: Not good or bad 2: Slightly bad 1: Bad

(Preparation of formulation preference improver)
Using myristic acid methyl ester as a solvent and a dispersant, 500 μg of 4,16-androstadien-3-one was dissolved in 10 mL of this solvent. In this solution, 5 g of porous silicic acid anhydride (trade name “Sunsphere H-122” manufactured by Asahi Glass Co., Ltd.) was dispersed.

  To the two types of cosmetics, the above-described formulation preference improver was added such that 10 ppm of 4,16-androstadien-3-one in the component was blended. The amount of water-absorbing spherical powder in each cosmetic after addition was 100 mg / mL. The female fragrant cosmetic was Comparative Example 1, and the female fragrant cosmetic was Comparative Example 2. And what added the preparation favorableness improvement agent based on this invention to them was set as Example 1, 2, respectively. The evaluation results of each example are shown below (Table 1).

(Examples 3 to 10 and Comparative Examples 3 to 13)
In the following Examples and Comparative Examples, spray antiperspirants (total 100% by weight) having the following two compositions were prepared as target preparations.
(Composition of antiperspirant 1)
Chlorhydroxyaluminum 25 (wt%)
Isopropylmethylphenol 0.1
Methylphenyl polysiloxane 2
Methyl polysiloxane 3
POE glyceryl triisostearate (20) 15
Dipropylene glycol 1
Perfume (those described in JP 2006-143602 A) 1
Isopropyl myristate balance

(Composition of antiperspirant 2)
Composition obtained by removing perfume from the composition of the antiperspirant 1:
Chlorhydroxyaluminum 25 (wt%)
Isopropylmethylphenol 0.1
Methylphenyl polysiloxane 2
Methyl polysiloxane 3
POE glyceryl triisostearate (20) 15
Dipropylene glycol 1
Isopropyl myristate balance

Next, the following four types were prepared as preparation sensitization improvers according to the present invention, and the four types of 16-androstene steroids used in Comparative Examples 3 to 6 deviated from the upper and lower limits of the appropriate range. Was prepared. The blending amount of the porous silicic acid anhydride (water-absorbing spherical powder) in these eight types of drug preference improvers was the same.
(Formulation preference improver 1)
4,16-androstadien-3-one 0.05 ppm
Solvent (Myristic acid ethyl ester) 10mL
Porous silicic anhydride (manufactured by Miyoshi Kasei Co., Ltd., trade name "Sunsphere SB-300) 5g
(Formulation preference improver 2)
4,16-androstadien-3-one 500 ppm
Solvent (Myristic acid ethyl ester) 10mL
Porous silicic anhydride (manufactured by Fuji Silysia Co., Ltd., trade name “MB-3A”) 5 g
(Formulation preference improver 3)
4,16-androstadien-3-one 0.025 ppm
5,16-androstadien-3-ol 0.025 ppm
Solvent (Myristic acid ethyl ester) 10mL
Porous silicic acid anhydride (product name “Sunsphere SB-300”, manufactured by Miyoshi Kasei Co., Ltd.) 5g
(Formulation preference improver 4)
4,16-androstadien-3-one 250 ppm
5,16-androstadien-3-ol 250 ppm
Solvent (Myristic acid ethyl ester) 10mL
Porous silicic anhydride (manufactured by Fuji Silysia Co., Ltd., trade name “MB-3A”) 5 g
(Formulation preference improver 5)
4,16-androstadien-3-one 0.04 ppm
Solvent (Myristic acid ethyl ester) 10mL
Porous silicic acid anhydride (product name “Sunsphere SB-300”, manufactured by Miyoshi Kasei Co., Ltd.) 5g
(Formulation preference improver 6)
4,16-androstadien-3-one 600 ppm
Solvent (Myristic acid ethyl ester) 10mL
Porous silicic anhydride (manufactured by Fuji Silysia Co., Ltd., trade name “MB-3A”) 5 g
(Formulation preference improver 7)
4,16-androstadien-3-one 0.02 ppm
5,16-androstadien-3-ol 0.02 ppm
Solvent (Myristic acid ethyl ester) 10mL
Porous silicic acid anhydride (product name “Sunsphere SB-300”, manufactured by Miyoshi Kasei Co., Ltd.) 5g
(Formulation preference improver 8)
4,16-androstadien-3-one 300 ppm
5,16-androstadien-3-ol 300 ppm
Solvent (Myristic acid ethyl ester) 10mL
Porous silicic anhydride (manufactured by Fuji Silysia Co., Ltd., trade name “MB-3A”) 5 g

  Sixteen types of spray antiperspirants (Examples 3 to 10 and Comparative Examples 3 to 10) were formulated by combining the two types of spray antiperspirants with the eight types of formulation preference improvers.

  That is, Example 3 is a combination of the spray antiperspirant 1 and the preparation likability improver 1, Example 4 is a combination of the spray antiperspirant 1 and the preparation likability improver 2, and Example 5 is a spray antiperspirant. Example 6 is a combination of the spray antiperspirant 1 and the formulation preference improver 4.

  Similarly, Example 7 is a combination of the spray antiperspirant 2 and the preparation likability improver 1, Example 8 is a combination of the spray antiperspirant 2 and the preparation likability improver 2, and Example 9 is a spray antiperspirant. Example 10 is a combination of the spray antiperspirant 2 and the preparation favorableness improver 4.

  Comparative Example 3 is a combination of the spray antiperspirant 1 and the preparation likability improver 5, Comparative Example 4 is a combination of the spray antiperspirant 1 and the preparation likability improver 6, and Comparative Example 5 is a spray antiperspirant. 1 is a combination of the spray antiperspirant 1 and the preparation preference improver 8.

  Similarly, Comparative Example 7 is a combination of the spray antiperspirant 2 and the preparation favorableness improving agent 5, Comparative Example 8 is a combination of the spray antiperspirant 2 and the preparation favorable sensitivity improving agent 6, and Comparative Example 9 is a spray antiperspirant. The combination of the agent 2 and the preparation favorableness improver 7 and Comparative Example 10 are the combination of the spray antiperspirant 2 and the preparation favorableness improving agent 8.

  In addition, as a comparative example 11, a formulation in which 3 ppm of only 4,16-androstadien-3-one was added to the spray antiperspirant 1 was prepared. Further, as Comparative Example 12, a formulation in which only 5% by weight of porous silicic anhydride was added to the spray antiperspirant 1 was prepared. Further, spray antiperspirants 1 and 2 to which nothing was added were prepared as Comparative Examples 13 and 14, respectively.

  In the same manner as the evaluation methods in Examples 1 and 2 and Comparative Examples 1 and 2, the samples of Examples 3 to 10 and Comparative Examples 3 to 14 were subjected to the favorable sensitivity of each preparation sample by 20 female panelists. evaluated. The results are shown in the following (Table 2) to (Table 6).

  As is clear from Examples 1 to 10 and Comparative Examples 1 to 14, the preparation preference improver of Examples containing a predetermined amount of 16-androstene steroid and a water-absorbing spherical powder is used as a target preparation. Even if it does not contain any component, the sensitivities of the preparation can be greatly improved by adding them to the preparation. On the other hand, in the comparative example in which only the 16-androstene steroid or only the water-absorbing spherical powder is added, it is not possible to obtain a sufficient improvement in favorable sensitivity.

(Examples 11 and 12)
In Examples 11 and 12, two prescription examples of a cream-like detergent and a high-sensitivity preparation obtained by adding the preparation-preferability improving agent of the present invention to a softener as preparations other than cosmetics are shown below.

(Example 11)
Creamy detergent composition 4,16-androstadien-3-one 0.001
LAPONITE XLG (manufactured by Nippon Silica) 0.3
Polyethylene powder (average particle size 100 μm) 0.3
Stearic acid 8
Palmitic acid 8
Myristic acid 18
Potassium hydroxide 5.5
POE (16) cetyl ether (trade name “EMALEX 116” manufactured by Nippon Emulsion Co., Ltd.) 2
Glycerin 15
PEG4000 5
Sorbitol 6
Purified lanolin 0.5
Orange oil 1
Highly polymerized polyethylene glycol (Union Carbite,
Product name "Polyox WSR-N750") 0.5
Darbilia extract 1
Birch extract 1
Smectite (Kunimine Industries, trade name “Kunipia F”) 0.3
Titanium oxide (average particle size 0.25 μm, rutile type) 1
Gunjo (average particle size 0.3-2 μm) 0.05
Bengala (average particle size 0.03 μm) 0.05
Nylon powder (average particle size 100 μm) 0.05
Edetate tetrasodium tetrahydrate 0.3
Fragrance 1
Purified water balance (%) 100.0

(Example 12)
The formulation shown in this example is a softener for clothing. Formulation examples are shown below (Table 7).

  As described above, the sensitization improver for preparations according to the present invention can improve the sensitivities in use of the preparations simply by adding them to various preparations.

Claims (5)

  A sensitization improver for pharmaceutical preparations comprising 16-androstene steroid and powder.   The likability improver for pharmaceutical preparation according to claim 1, wherein the powder is a water-absorbing spherical powder.   The sensitization improver for pharmaceutical preparation according to claim 1 or 2, wherein the 16-androstene steroid is 4,16-androstadien-3-one.   The likability improver for pharmaceutical preparation according to any one of claims 1 to 3, wherein the preparation is a cosmetic.   A sensitization improver for pharmaceutical preparation according to any one of claims 1 to 3 is added, and 0.01 to 100 ppm of 16-androstene steroid contained in the sensitization improver is contained. Highly sensitive preparation.