JP2008154589A5 - - Google Patents
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- JP2008154589A5 JP2008154589A5 JP2008000091A JP2008000091A JP2008154589A5 JP 2008154589 A5 JP2008154589 A5 JP 2008154589A5 JP 2008000091 A JP2008000091 A JP 2008000091A JP 2008000091 A JP2008000091 A JP 2008000091A JP 2008154589 A5 JP2008154589 A5 JP 2008154589A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- pharmaceutical composition
- cancer
- nmb
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 102000004965 antibodies Human genes 0.000 claims 16
- 108090001123 antibodies Proteins 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 201000011510 cancer Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 5
- 102000005614 monoclonal antibodies Human genes 0.000 claims 4
- 108010045030 monoclonal antibodies Proteins 0.000 claims 4
- 230000002159 abnormal effect Effects 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025650 Malignant melanoma Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 208000000409 Breast Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010027476 Metastasis Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000000051 modifying Effects 0.000 claims 1
Claims (18)
- ＮＭＢポリペプチドに免疫特異的に結合する、単離された抗体。
- 前記ＮＭＢポリペプチドがＴＳＣ１２２のアミノ酸配列を含む、請求項１に記載の抗体。
- 前記抗体がモノクローナル抗体である、請求項１に記載の抗体。
- 前記抗体がヒトモノクローナル抗体である、請求項１に記載の抗体。
- 前記抗体がヒト化抗体である、請求項１に記載の抗体。
- 請求項１に記載の抗体およびキャリアを含有する薬学的組成物。
- ＮＭＢの異常な発現または活性によって特徴付けられる疾患または障害を処置するための薬学的組成物であって、ＮＭＢの発現または活性を調節する単離された抗体を含有する、薬学的組成物。
- 前記抗体がＮＭＢの発現または活性を阻害する、請求項７に記載の薬学的組成物。
- 前記ＮＭＢの異常な発現または活性によって特徴付けられる疾患または障害が癌である、請求項７に記載の薬学的組成物。
- 前記癌が乳癌である、請求項９に記載の薬学的組成物。
- 前記癌が、黒色腫、腎癌、肺癌、および、ＣＮＳ癌から選択される、請求項９に記載の薬学的組成物。
- 前記癌が原発腫瘍からの転移である、請求項９に記載の薬学的組成物。
- 前記原発腫瘍が、胸部腫瘍、黒色腫、腎癌、肺癌、および、ＣＮＳ癌から選択される、請求項１２に記載の薬学的組成物。
- 前記薬学的組成物が、ＮＭＢの異常な発現または活性に関連する症状の出現の前に投与されて、それによって、該疾患または障害の進行を遅らせるように処方される、請求項７に記載の薬学的組成物。
- 全身または局所的に投与されるように処方される、請求項７に記載の薬学的組成物。
- 前記抗体がモノクローナル抗体である、請求項７に記載の薬学的組成物。
- 前記抗体がヒトモノクローナル抗体である、請求項７に記載の薬学的組成物。
- 前記抗体がヒト化抗体である、請求項７に記載の薬学的組成物。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25426800P | 2000-12-08 | 2000-12-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002548191A Division JP2005516579A (ja) | 2000-12-08 | 2001-12-10 | 障害に関連する結節硬化複合症の検出法および処置法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008154589A JP2008154589A (ja) | 2008-07-10 |
| JP2008154589A5 true JP2008154589A5 (ja) | 2009-05-07 |
Family
ID=22963608
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002548191A Pending JP2005516579A (ja) | 2000-12-08 | 2001-12-10 | 障害に関連する結節硬化複合症の検出法および処置法 |
| JP2008000091A Pending JP2008154589A (ja) | 2000-12-08 | 2008-01-04 | 結節性硬化症複合体関連障害の検出法および処置法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002548191A Pending JP2005516579A (ja) | 2000-12-08 | 2001-12-10 | 障害に関連する結節硬化複合症の検出法および処置法 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US20030124534A1 (ja) |
| EP (1) | EP1385993B8 (ja) |
| JP (2) | JP2005516579A (ja) |
| AT (1) | ATE506075T1 (ja) |
| AU (1) | AU2002226079A1 (ja) |
| CA (1) | CA2431861A1 (ja) |
| DE (1) | DE60144493D1 (ja) |
| DK (1) | DK1385993T3 (ja) |
| WO (1) | WO2002046475A2 (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030211488A1 (en) | 2002-05-07 | 2003-11-13 | Northwestern University | Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection |
| CA2439440A1 (en) * | 2002-09-05 | 2004-03-05 | Emory University | Treatment of tuberous sclerosis associated neoplasms |
| EP1522857A1 (en) * | 2003-10-09 | 2005-04-13 | Universiteit Maastricht | Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2 |
| NZ549040A (en) | 2004-02-17 | 2009-07-31 | Schering Corp | Use for interleukin-33 (IL33) and the IL-33 receptor complex |
| WO2006071441A2 (en) | 2004-11-30 | 2006-07-06 | Curagen Corporation | Antibodies directed to gpnmb and uses thereof |
| US20120252877A1 (en) * | 2009-08-14 | 2012-10-04 | Theramind Research, Llc | Methods and compositions for treatment of tuberous sclerosis complex |
| US9925202B2 (en) | 2013-03-04 | 2018-03-27 | Brigham And Women's Hospital, Inc. | Treatment of lymphangioleiomyomatosis |
| US20160129030A1 (en) * | 2013-06-14 | 2016-05-12 | The Brigham And Women's Hospital, Inc. | Treatment of mtor hyperactive related diseases and disorders |
| WO2023178250A1 (en) * | 2022-03-17 | 2023-09-21 | SpringWorks Therapeutics Inc. | Treatment of tuberous sclerosis with mirdametinib |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| ATE141646T1 (de) | 1986-04-09 | 1996-09-15 | Genzyme Corp | Genetisch transformierte tiere, die ein gewünschtes protein in milch absondern |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US6232452B1 (en) * | 1993-12-24 | 2001-05-15 | Julian R. Sampson | Tuberous sclerosis 2 gene and uses thereof |
| US5871697A (en) * | 1995-10-24 | 1999-02-16 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| AU725186B2 (en) * | 1995-11-16 | 2000-10-05 | Baylor College Of Medicine | Method for identifying metastatic sequences |
| US20020147143A1 (en) | 1998-03-18 | 2002-10-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| NZ514818A (en) | 1999-04-02 | 2004-04-30 | Corixa Corp | Compounds and methods for therapy and diagnosis of lung cancer |
| US6620615B1 (en) * | 1999-04-23 | 2003-09-16 | Curagen Corporation | G-protein coupled receptor—encoding nucleic acids |
| EP1354040A2 (en) | 2000-07-20 | 2003-10-22 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU2002255458A1 (en) | 2000-10-20 | 2002-08-19 | University Of Medicine And Dentistry New Jersey Medical School | Hematopoietic growth factor inducible neurokinin-1 gene |
| WO2002086122A2 (en) | 2001-03-14 | 2002-10-31 | Hybrigenics | Protein-protein interactions in adipocytes |
| JP2005527180A (ja) | 2001-04-18 | 2005-09-15 | プロテイン デザイン ラブス， インコーポレイテッド | 肺がんの診断方法、肺がんの修飾因子の組成及びスクリーニングの方法 |
-
2001
- 2001-12-10 AT AT01995497T patent/ATE506075T1/de not_active IP Right Cessation
- 2001-12-10 AU AU2002226079A patent/AU2002226079A1/en not_active Abandoned
- 2001-12-10 CA CA002431861A patent/CA2431861A1/en not_active Abandoned
- 2001-12-10 EP EP01995497A patent/EP1385993B8/en not_active Expired - Lifetime
- 2001-12-10 DE DE60144493T patent/DE60144493D1/de not_active Expired - Lifetime
- 2001-12-10 DK DK01995497.3T patent/DK1385993T3/da active
- 2001-12-10 WO PCT/US2001/047839 patent/WO2002046475A2/en active Search and Examination
- 2001-12-10 JP JP2002548191A patent/JP2005516579A/ja active Pending
- 2001-12-10 US US10/016,253 patent/US20030124534A1/en not_active Abandoned
-
2004
- 2004-11-16 US US10/991,173 patent/US20050181391A1/en not_active Abandoned
-
2008
- 2008-01-04 JP JP2008000091A patent/JP2008154589A/ja active Pending
- 2008-04-02 US US12/080,362 patent/US20080292624A1/en not_active Abandoned
-
2012
- 2012-05-02 US US13/462,300 patent/US9051615B2/en not_active Expired - Fee Related
-
2015
- 2015-05-07 US US14/706,105 patent/US20150232948A1/en not_active Abandoned
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