JP2008143819A5 - - Google Patents
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- JP2008143819A5 JP2008143819A5 JP2006331463A JP2006331463A JP2008143819A5 JP 2008143819 A5 JP2008143819 A5 JP 2008143819A5 JP 2006331463 A JP2006331463 A JP 2006331463A JP 2006331463 A JP2006331463 A JP 2006331463A JP 2008143819 A5 JP2008143819 A5 JP 2008143819A5
- Authority
- JP
- Japan
- Prior art keywords
- component
- cell death
- oxidative stress
- induced cell
- preventing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108009000578 Oxidative Stress Proteins 0.000 claims 8
- 230000030833 cell death Effects 0.000 claims 8
- 230000036542 oxidative stress Effects 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 206010008118 Cerebral infarction Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000010125 Myocardial Infarction Diseases 0.000 claims 2
- 206010053643 Neurodegenerative disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- CONYTTFKIUJZOF-UHFFFAOYSA-N 8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octanoic acid Chemical compound CCCCCC1CC1CC1C(CCCCCCCC(O)=O)C1 CONYTTFKIUJZOF-UHFFFAOYSA-N 0.000 claims 1
- 206010059512 Apoptosis Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 210000004369 Blood Anatomy 0.000 claims 1
- SBJKKFFYIZUCET-JLAZNSOCSA-N Dehydro-L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-JLAZNSOCSA-N 0.000 claims 1
- ZERULLAPCVRMCO-UHFFFAOYSA-N Dipropyl sulfide Chemical compound CCCSCCC ZERULLAPCVRMCO-UHFFFAOYSA-N 0.000 claims 1
- 229960000304 Folic Acid Drugs 0.000 claims 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims 1
- 229960005356 Urokinase Drugs 0.000 claims 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims 1
- 229940029983 VITAMINS Drugs 0.000 claims 1
- 206010047116 Vascular inflammations Diseases 0.000 claims 1
- 229930003779 Vitamin B12 Natural products 0.000 claims 1
- 229930003268 Vitamin C Natural products 0.000 claims 1
- 229940046009 Vitamin E Drugs 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 229940021016 Vitamin IV solution additives Drugs 0.000 claims 1
- SSCDRSKJTAQNNB-WVZYQCMWSA-N [3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[(9E,12E)-octadeca-9,12-dienoyl]oxypropyl] (9E,12E)-octadeca-9,12-dienoate Chemical compound CCCCC\C=C\C\C=C\CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC SSCDRSKJTAQNNB-WVZYQCMWSA-N 0.000 claims 1
- 235000011054 acetic acid Nutrition 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000000702 anti-platelet Effects 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 230000003078 antioxidant Effects 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 229940076810 beta Sitosterol Drugs 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 125000003346 cobalamin group Chemical group 0.000 claims 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 1
- 235000017173 flavonoids Nutrition 0.000 claims 1
- 150000002215 flavonoids Chemical class 0.000 claims 1
- 229930003935 flavonoids Natural products 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 150000002516 isoflavones Chemical class 0.000 claims 1
- 229930012948 isoflavones Natural products 0.000 claims 1
- 235000008696 isoflavones Nutrition 0.000 claims 1
- 150000002596 lactones Chemical class 0.000 claims 1
- 229940086319 nattokinase Drugs 0.000 claims 1
- 108010073682 nattokinase Proteins 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 150000008442 polyphenolic compounds Chemical class 0.000 claims 1
- 235000013824 polyphenols Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229950005143 sitosterol Drugs 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 235000007586 terpenes Nutrition 0.000 claims 1
- 150000003505 terpenes Chemical class 0.000 claims 1
- 230000002537 thrombolytic Effects 0.000 claims 1
- SOECUQMRSRVZQQ-UHFFFAOYSA-N ubiquinone-1 Chemical compound COC1=C(OC)C(=O)C(CC=C(C)C)=C(C)C1=O SOECUQMRSRVZQQ-UHFFFAOYSA-N 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 235000019163 vitamin B12 Nutrition 0.000 claims 1
- 239000011715 vitamin B12 Substances 0.000 claims 1
- 235000019154 vitamin C Nutrition 0.000 claims 1
- 239000011718 vitamin C Substances 0.000 claims 1
- 150000003700 vitamin C derivatives Chemical class 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- 150000003712 vitamin E derivatives Chemical class 0.000 claims 1
- 229930003231 vitamins Natural products 0.000 claims 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N β-Sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 claims 1
Claims (8)
- ８−［２−（２−ペンチル−シクロプロピルメチル）−シクロプロピル］−オクタン酸又はその塩を含む、酸化ストレス誘導細胞死の抑制剤。
- 酸化ストレス誘導細胞死の抑制剤が、脳梗塞又は心筋梗塞を予防又は治療するための医薬である、請求項１記載の剤。
- 酸化ストレス誘導細胞死の抑制剤が、神経変性疾患を予防又は治療するための医薬である、請求項１記載の剤。
- 酸化ストレス誘導細胞死により引き起こされる疾患の予防又は保護に有用な別の成分をさらに含む、請求項１記載の剤。
- 酸化ストレス誘導細胞死により引き起こされる疾患の予防又は保護に有用な別の成分が、動脈硬化の予防又は改善作用を有する成分、抗酸化作用を有する成分、血管炎症の予防又は改善作用を有する成分、ホモシステインの血中濃度の低下作用を有する成分、抗血小板作用を有する成分、血栓溶解作用を有する成分、及びアポトーシスの抑制作用を有する成分から選ばれる１以上の成分である、請求項４記載の剤。
- 酸化ストレス誘導細胞死により引き起こされる疾患の予防又は保護に有用な別の成分が、ポリフェノール、コエンザイムＱ１、β−シトステロール、イソフラボン、メビニン酸、ビタミンＣ、ビタミンＥ、フラボノイド類、テルペン類、葉酸、ビタミンＢ６、ビタミンＢ１２、セスキルペンラクトン、ウロキナーゼ、ナットウキナーゼ、ジリノレオイルホスファチジルエタノールアミン、硫化プロピル、リンゴペクチン、酢酸、ＥＰＡ、及びＤＨＡから選ばれる１以上の成分である、請求項４記載の剤。
- 酸化ストレス誘導細胞死の抑制剤が、脳梗塞又は心筋梗塞から哺乳動物を予防又は保護するための食品である、請求項４〜６のいずれか１項記載の剤。
- 酸化ストレス誘導細胞死の抑制剤が、神経変性疾患から哺乳動物を予防又は保護するための食品である、請求項４〜６のいずれか１項記載の剤。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006331463A JP2008143819A (ja) | 2006-12-08 | 2006-12-08 | 酸化ストレス誘導細胞死の抑制剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006331463A JP2008143819A (ja) | 2006-12-08 | 2006-12-08 | 酸化ストレス誘導細胞死の抑制剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008143819A JP2008143819A (ja) | 2008-06-26 |
| JP2008143819A5 true JP2008143819A5 (ja) | 2009-11-26 |
Family
ID=39604392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006331463A Pending JP2008143819A (ja) | 2006-12-08 | 2006-12-08 | 酸化ストレス誘導細胞死の抑制剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2008143819A (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2683021T3 (es) * | 2008-07-28 | 2018-09-24 | Blanchette Rockefeller Neurosciences Institute | Compuestos activadores de la PKC para el tratamiento de enfermedades neurodegenerativas |
| WO2012006510A1 (en) | 2010-07-08 | 2012-01-12 | Alkon Daniel L | Fatty acid protein kinase c activators and anticoagulant for the treatment of stroke |
| WO2012067111A1 (ja) * | 2010-11-16 | 2012-05-24 | 株式会社西崎創薬研究所 | ＰＫＣ－ε活性化剤 |
| US9603821B2 (en) | 2013-02-22 | 2017-03-28 | Nishizaki Bioinformation Research Institute | Inhibitor of τ protein phosphorylation |
| EP2982370A4 (en) | 2013-04-04 | 2016-10-12 | Nishizaki Bioinformation Res Inst | AGENT PROMOTING THE SYNTHESIS / REGENERATION OF ELASTIN |
| EP2997967A4 (en) | 2013-05-17 | 2017-01-04 | Nishizaki Bioinformation Research Institute | Cell membrane transport promoter for selective 5-ht1a serotonin receptors |
| WO2015105094A1 (ja) | 2014-01-07 | 2015-07-16 | 株式会社西崎創薬研究所 | 糖尿病治療薬 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR215700A0 (en) * | 2000-12-19 | 2001-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Carboxylic acid compound having cyclopropane ring |
-
2006
- 2006-12-08 JP JP2006331463A patent/JP2008143819A/ja active Pending
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