JP2008110922A - Food composition and cosmetic composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new improved composition which comprises the extract powder of a Labiatae plant, Coleus froskohlii, and is used for herb treatments for optimizing the increase of lean body weight, the improvement of a body composition, and the reduction of the body weight. <P>SOLUTION: The powder of an extract from a Labiatae plant, Coleus froskohlii, is compounded with suitable known natural health food raw materials to provide a composition optimal to the increase of lean body weight, the improvement of the body composition, and the decrease of the body weight. The food composition comprises the powder of the extract from the Labiatae plant, Coleus froskohlii, the extract powder of Paullinia cupana H.B.K. var. sorbilis (Mart.) Ducke, and the extract powder of Mucuna pruriens(Dolichos pruriens). <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a novel food or cosmetic composition having an excellent diet effect. In particular, the present invention relates to an improved composition of an extract from the Labiatae plant Coleus forskori, which is famous as a food or cosmetic composition having an excellent diet effect.

  Herbal formulas using the extract of Lamiaceae coleus force cori root, which has been used in pickles and spices for a long time, are known to increase slow fat body weight and optimize body composition. . The extraction method and application have been patented by one of the inventors of the present application and registered worldwide (Patent Document 1). This product is sold by Savinsa Corp. (USA). The main component of this extract is diterpene-based forskolin, and products containing forskolin 10% (W / W) are on the market. Ingestion of this product at 250 mg / day has been proven to lead to safe and effective weight loss, with an oral LD50 of 2000 mg / Kg or more.

  Guarana's scientific name was called Paulinia cupana H.B.K. var. Sorbilis (Mart.) Ducke and was found by 18th century German medicinal botanist C.F.Paullini. Commercial-based guarana is made from seed. One of the unique contents of guarana is the same stimulant as caffeine called galanin, which is 2.5 times more effective than caffeine in coffee and tea. Galanin, unlike caffeine, is released slowly and acts slowly on the body. This is because guarana seeds are high in fat and prevent galanin from being absorbed immediately. The energy used by galanin is not released rapidly. This slow mechanism of galanin prevents the nervous irritation that occurs in coffee. Traditionally, guarana has been used by Indians for intestinal upsets, especially diarrhea. Guarana syrup is made as an energy-generating soft drink and is very popular in Brazil. However, the main use in Europe and the United States is to reduce headaches. Recently, guarana has been promoted as a cheerful supplement like coffee and caffeine. The main component of guarana, galanin, has the effect of removing lactic acid in the muscles, relieving fatigue and activating the function of the muscles, improving the basic metabolic capacity of the muscles, and galanin moderately appetite Guarana is recognized as a very effective diet because of its ability to suppress and normalize the rhythm of eating habits and to effectively remove waste substances and the like due to its vasodilatory properties. Guarana extract powder is also widely sold in the health food field.

  Mucuna pruriens (Dolichos pruriens), the raw material of Mucuna extract powder, is commonly called velvet bean (s), cowhage, sea beans, nescafe, kratzbohnen, cowitch, ojo de venado, true sea-bean, kaw ai ing. This plant makes a bunch of pods, but it is known for its Mucuna beans and is covered with red-orange velvet-like hair, and is known as the velvet bean. In Central America and Brazil, beans have been roasted into flour and used as a substitute for coffee for decades, so in this region also called nescafe. In Guatemala, Ketchy natives cultivated and beans were cooked as vegetables. Velvet beans are made in tropical regions such as Africa, India and the West Indies. One of the main components of velvet bean is L-dopa (4-3,4-dihydroxyphenylalanine). It changes to dopamine in the body and transmits signals at the nerve junction. Velvet Bean has a long history of being used in folk medicine in South America and Ayurvedic medicine in India, with anthelmintic (intestinal worms), dysentery, diarrhea, intestinal fermentation, snake bites, reduced sexuality It was used for cough, tuberculosis, impo, rheumatic disorders, muscle pain, infertility, gout, mental retardation, diabetes and cancer. In addition to L-dopa, Mucuna extract powder contains glutathione (antioxidant in the body), serotonin, reticin, gallic acid and glycoside. Seeds are a source of minerals such as zinc and manganese, and are high in protein, carbohydrates, lipids, and fibers. Velvet beans are a sports nutrition genre that has gained popularity over the past few years. L-Dopa increases testosterone and stimulates growth hormone, which increases muscle and slow fat body weight. Appeared as a component of weight loss, sexual recovery, brain / memory, anti-aging, and bodybuilder formula. Traditionally it has been used as a tonic against nervous breakdown. The possibility of treatment for Parkinson's disease was studied by including a high content of L-dopa in the seeds. Velvet bean is considered as an alternative to L-dopa containing chemicals. An in vivo study was conducted to confirm the blood glucose lowering effect of velvet bean. Root, fruit, and seed ethanol-water extracts lowered rat hyperglycemia by more than 30%. In human studies, ethanol extract 200 mg / day reduced blood glucose levels by 40% within a month. And it decreased 51% in April. In another study, leaf decoction lowered the total cholesterol level in rats and the same effect on seeds. Blood glucose levels were examined in diabetic rabbits using velvet bean powder. When diabetic rabbits were given 1 g and 2 g per kilogram of body weight, their blood glucose level was significantly reduced compared to no treatment. Thus, velvet bean contains a hypoglycemic component that either promotes insulin secretion or / or directly acts like an insulin. Indian clinical studies are convinced that this plant has aphrodisiac activity as well as anabolic and growth hormone stimulating effects. L-dopa stimulates growth hormone secretion from the pituitary gland. L-dopa and dopamine suppress the secretion of a hormone called prolactin. Prolactin is a hormone secreted from the pituitary gland. The level of prolactin increase is thought to cause inability to erect men and cause infertility in women. In one study, 56 men ingested seeds by mouth for 4 weeks improved erection, persistence of sexual intercourse, and satisfaction after intercourse. Seeds are described in terms of promoting fertilizing ability of men and effects on sperm production (sperm count and vitality). Mucuna extract powder is also widely sold in the health food field.

Special table 2001-508801 gazette

  The object of the present invention is to provide an improved composition of the extract of Lamiaceae Coleus forcecoli, which provides a novel composition for herbal formulations that optimizes slow fat body weight gain, body composition improvement, weight loss. It is to provide.

  The present invention has succeeded in providing a composition in which a known natural health food ingredient suitable for a Coleaceae coleus forcoli extract is blended to optimize the increase in slow fat weight, improvement in body composition, and weight loss.

The present invention comprises:
1. A food or cosmetic composition comprising an extract powder from the Labiatae plant Coleus forskori, a guarana extract powder, and a Mucuna extract powder.
2. A food or cosmetic composition comprising a plant extract containing forskolin, a plant extract containing L-DOPA, and a plant extract containing caffeine.
3. 3. The food or cosmetic composition according to item 1 or 2, which is taken for longevity, slimming acquisition, bone mass increase, weight loss, and / or body fat reduction.
4). A food or cosmetic composition according to paragraph 1 for human and / or animal application. .

  The novel composition of the present invention has excellent slow fat body weight gain, improved body composition, and weight loss effect, and the speed of body fat reduction is astonishing, about 4 times that of single body fat. . The novel composition of the present invention eliminates the tendency of loose stool and abdominal pain, such as ingestion of a Coleaceae coleus forcoli extract alone.

  The novel composition of the present invention is a food or cosmetic composition comprising an extract powder from the Labiatae plant Coleus forskori, a guarana extract powder, and a Mucuna extract powder.

The method for preparing an extract powder from the Labiatae plant Coleus forskori is described in the aforementioned patent, and the extract powder itself from the Labiatae plant Coleus forskori can be purchased as a product. The components of this product are shown in FIG. This extract powder is obtained by extracting the raw Coleus forskori root dry pulverized product with ethanol, concentrating it with a low-temperature vacuum method, obtaining a thick paste, purifying it using ethanol, blending maltodextran with the extract, , Blended and prepared.
Guarana extract powder is also widely used in the field of health foods, its preparation method is known, and commercial products can be purchased. This extract powder is obtained by extracting the crushed material of raw ganara seeds twice with a 75% alcohol aqueous solution at low temperature (5 to 15 ° C.) for about 1 hour, concentrating the extract, filtering, and drying at low temperature under vacuum. Concentrated and stabilized at high pressure and high temperature for 5 to 10 seconds, blended with maltodextrin, spray-dried, meal-blended, and prepared. The components of this product are shown in FIG. This component inhibits cAMP degrading enzyme Phosphodieselase (PDE) activity by about 40% and prevents cAMP from being reduced. It is maintained in the body and has a diet synergy effect. PDE inhibits the activity of cAMP and blocks the release of fatty acids, halving the effect of fat reduction, but this component makes it possible to break down stored fat into fatty acids free of charge . It has about three times the fat burning effect of coffee caffeine, and guarana-derived caffeine has excellent sustainability.
Mucuna extract powder is also widely used in the field of health foods, its preparation method is known, and commercially available products can be purchased. This extract powder is obtained by extracting the ground material of Mucuna root twice with 75% alcohol aqueous solution at low temperature (5-15 ° C) for about 1 hour, concentrating the extract, filtering, and drying at low temperature under vacuum. Concentrated and stabilized at high pressure and high temperature for 5 to 10 seconds, blended with maltodextrin, spray-dried, meal-blended, and prepared. The components of this product are shown in FIG. An extract containing L-DOPA. L-DOPA is a dopamine precursor. Dopamine has a positive effect on mental health such as happiness and motivation, as well as suppression of appetite and memory, leading to increased resistance to stress. It also has growth hormone-like action. Ingestion of this component promotes LBM (lean body mass) increase, growth hormone and sex hormone synthesis, and increases LBM, and LMB burns fat to reduce body fat.

  The above three types are all in a dry powder state, and the powdered extract from Lamiaceae plant Coleus forskori is 15 to 85 parts by weight, preferably 50 to 60 parts by weight, and guarana extract powder is preferably part by weight in the mixer 18 to 28 parts by weight and 5 to 80 parts by weight, preferably 18 to 28 parts by weight of Mucuna extract powder are blended and mixed uniformly. In addition, the active ingredient of the powder extract from the Labiatae plant Coleus forskori is forskolin, and the daily intake varies depending on the degree of purification. For example, forskolin may be ingested 10 to 100 mg / day. . From this, the determination of the above blending ratio is that the extract powder from Coleus forskori contains 10-12% (W / W) forskolin, so the extract powder from coleus forskori depends on the degree of purification. It is possible to reduce the compounding ratio. For example, in the case of a formulation containing 22% (W / W) of forskolin in the extract powder from Coleus forskori, 25-30 parts by weight of the extract powder from coleus forskori and 18-28 weight of guarana extract powder Part, Mucuna extract powder can be blended in 18 to 28 parts by weight. In addition, it can change similarly according to a refinement | purification degree. Similarly, the guarana extract powder and the mucna extract powder can be similarly changed according to the guaranine for the guarana extract powder, the purity of caffeine, and the purity of L-DOPA for the mucna extract powder. In the case of guarana extract powder, the above formulation values are 20-25% (W / W) containing preparation of caffeine, and in the case of Mucuna extract powder, 3-25 (preferably 15-25)% (W / W) of L-DOPA. ) Containing preparations, and the compounding ratio can be changed according to the degree of purification.

  Guarana extract powder and Mucuna extract powder add to and synergize with the function of the extract powder from Coleus forskori to maintain a healthy body, proper weight maintenance, maintain a healthy resting metabolic rate (RMR) that improves durability, It functions to increase bioenergy levels and suppress appetite. In addition, guarana extract powder and Mucuna extract powder do not have body fat suppression effect by themselves.

  Guarana extract powder is useful for promoting lipolysis or increasing the release of fatty acids from non-essential stored body fat. The liberated fatty acid acts as a fuel for the function of the extract powder from Coleus forskori and enhances the function of reducing body weight by the extract powder from coleus forskori. It consumes free fatty acids for energy and maintains a healthy RMR. The guarana extract powder contains a caffeine-like compound called guaranine that exerts a caffeine function about 2.5 times that of caffeine, and its function is sustained by the slow release mechanism of this compound. It is supposed to be. In conclusion, galana extract powder increases lipid metabolism and its main function is due to galana methylxanthine such as caffeine and guananine.

  The pea powder supports the functional mechanism of the extract powder from Coleus forskori. Extract powder from Coleus forskori activates an enzyme called adenylate cyclase. Its main enzyme is cyclic AMP (cAMP). cAMP is a factor that increases the enhancement of hormones that directly consume non-essential body fat and build an essential lean constitution. As for the naturally-occurring hormone (L-DOPA) of peanut, there is research on hormones (for example, human growth hormone (HGH)) that increase the fine constitution. HGH decreases with aging, which leads to a decrease in RMR, which increases body fat and weight. Inactive metabolic rates have had inadequate results in many weight loss diets. A low resting metabolic rate situation results in a high rate of well-known rebound. The blend of peppercorns of the present invention helps people who are trying a weight loss diet maintain and increase healthy RMR. In addition, the blending of millet bean can improve mental status and prevent depression.

The resting metabolic rate was examined in 20 volunteers in the middle age. Standard treatment (appetite suppressant) and diet or diet diet and resistance exercises were randomly assigned. Both groups took an ultra-low energy diet (ie 800 kcal / day liquid typical meal) for 12 weeks. The standard treatment + diet diet group lost a significant amount of lean body weight. However, lean body weight loss was not observed in resistance exercise and diet diet groups. In addition, resistance exercise and diet diet groups have resulted in increased resting metabolic rates. On the other hand, resting metabolic rate decreased in the standard treatment + diet diet group.
The effect of the mixed composition of extract powder, guarana extract powder, and mucuna extract powder from the Labiatae plant Coleus forskori of the present invention mimics the mechanism of weight loss diet method that has been successful by such diet and exercise. .

  When used as health foods or cosmetics, the novel combination composition of the present invention may be mixed with formulation adjuvants such as excipients, carriers and diluents that can be used in normal formulation as appropriate. , Tablets, capsules, powders, syrups, granules, pills, suspensions, emulsions, solutions, powder formulations, suppositories, etc., and preferably taken from the oral, rectal, and external use. The amount of intake, the method of intake, and the number of intakes can be appropriately selected according to the age, weight, and symptoms of the subject, but for adults, this can be achieved by oral or rectal administration, or by topical or transdermal administration. The novel combination composition of the present invention (extract powder from Lamiaceae plant Coleus forskori, guarana extract powder, mucuna extract powder) per day, 300-1500 mg / adult, preferably 500-1300 mg / adult, more preferably 700-1000 mg / Adults should be taken once to several times.

  The subject of application of the novel composition of the present invention can be ingested for the purpose of increasing slow fat body weight, improving body composition, and losing weight.

Although the preparation method of the novel compounding composition of the present invention will be described in the following examples, this shows a representative example of the novel compounding composition and does not limit the present invention.
Example 1
A mixture of 56 parts by weight of the extract from the Labiatae plant Coleus forskori, 22 parts by weight of guarana extract powder, and 22 parts by weight of Mucuna extract powder was mixed and homogenized at room temperature, and filled into gelatin hard capsules in an amount of 225 mg. As another compounding agent, 250 mg by weight of the extract powder from Coleus forskori, 100 parts by weight of guarana extract powder, and 100 parts by weight of mucna extract powder were mixed at room temperature and homogenized, and 450 mg each in a gelatin hard capsule Filled.
The specifications and provisions of each component used are as follows.
Extract powder from Lamiaceae coleus forskori:
Coleus-Forscoli Extract Powder from SABISA Corporation The forskolin content is 10% or more and less than 12% by HPLC test. FIG.
Guarana extract powder:
Guarana seed extract powder, produced by MiniStar International Inc., contains 22% or more of caffeine [22.08% (W / W)] by HPLC analysis. FIG.
Mucuna extract powder:
Mucuna root extract powder manufactured by iniStar International Inc., containing 5% (W / W) or more of L-DOPA (W / W) by HPLC analysis]. FIG.

Example 2
Emulsifiers can be prepared using capryl / caprin triglyceride, octyl stearate, glyceryl monostearate, isopropyl myristate, myristyl myristate, and the like. If desired, wetting agents such as glycerin can be added. In addition, preservatives such as sodium methyl paraben, sodium propyl paraben can be added if desired. In such a normal emulsified preparation, 56 parts by weight of an extract powder from the Labiatae plant Coleus forskori, 22 parts by weight of guarana extract powder, and 22 parts by weight of Mucuna extract powder can be prepared. The cream formulation is applied 1 to 3 times daily, for example, 1 ounce per skin surface and repeated for at least 4 weeks. Thereby, a formulation reduces the circumference | surroundings of an application part. A suitable application part is an arm, a thigh, a waist line, etc., for example.
(Formulation example) Emulsifier
Emulsifying wax NF, Steraeth 21 (BRIJ 721), Steareth 2 (BRIJ 72)
Actives: Forskolin 0.5%, guarana extract powder 0.5%, peppercorn extract powder 1.0%, N-methylpyrrolidone 1.5% (solvent)

Example 3
The compositions of the present invention are also taken orally as soft drinks, yogurts, nutrition bars, chewing gum formulations and the like. Of course, oral preparations can be used with ingredients such as citrus fruits, citrus extracts, pomegranate extracts, vegetable extracts, meat extracts, fish extracts, oligofructose, galactooligosaccharides, and lactulose, natural bitterness, sour, and sachets. In such a normal preparation, an extract powder from the Labiatae plant Coleus forskori can be prepared at a blending ratio of 56 parts by weight, guarana extract powder 22 parts by weight, and mucna extract powder 22 parts by weight.

A representative experiment using the composition of the present invention is shown below.
(Comparative Experimental Example 1)
For 6 obese women, an extract powder preparation from a commercial Lamiaceae plant Coleus forskori was administered at 500 mg / day for 8 weeks, and body weight, body fat, and lean rate were measured. As a result, the effect was confirmed with a tendency as shown in FIG.

(Experimental example 1)
Eight obese women (average body weight 62.2 kg) were orally ingested twice a day before meals with the composition of the present invention (formulation of Example 1) twice a day. Thereafter, body weight and body fat percentage were measured at 1 week and 2 weeks. 5 to 10 show the results. FIG. 5 shows specific reduction rates (%) in each volunteer, and shows that body weight decreased by an average of 3.2% and body fat decreased by an average of 10.8% in two weeks. FIG. 6 is a graph of this. FIG. 7 shows changes in specific body weight (Kg), and FIG. 8 is a graph. FIG. 9 is a graph showing a specific change in body fat percentage (%), and FIG. 10 is a graph. As a result, compared with the comparative experiment, in the case of the composition of the present invention, the change in body weight was substantially the same, but the rate of decrease in the body fat percentage was astonishing at about 4 times.

  The novel composition of the present invention can be effectively used to reduce body fat.

Extract powder from Lamiaceae coleus forskori Guarana extract powder Mucuna extract powder Results of Comparative Experiment Example 1 Results of Experimental Example 1 (Change numbers of body weight and body fat percentage) Results of Experimental Example 1 (weight, body fat percentage change graph) Results of Experimental Example 1 (weight change numbers) Results of Experimental Example 1 (weight change graph) Results of Experimental Example 1 (Change in body fat percentage) Results of Experimental Example 1 (Change graph of body fat percentage)

Claims (4)

A food or cosmetic composition comprising an extract powder from the Labiatae plant Coleus forskori, a guarana extract powder, and a Mucuna extract powder. A food or cosmetic composition comprising a plant extract containing forskolin, a plant extract containing L-DOPA, and a plant extract containing caffeine. The food or cosmetic composition according to claim 1 or 2, which is taken for longevity, slimming gain, bone mass increase, weight loss, and / or body fat loss. A food or cosmetic composition according to claim 1 for human and / or animal application.