JP2008063281A - Liquid preparation composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a liquid preparation composition leading the consciousness level of a brain in a human to a relaxed state, and bringing the effective improvement of calculation performance. <P>SOLUTION: This oral composition is provided by containing caffeine and a root stem extract derived from Polygonatum falcatum as active ingredients. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

The present invention relates to a liquid composition that brings about an effect of improving human computing ability by leading a brain consciousness level to a relaxed state.

  Caffeine is known as a component having a central excitatory action contained in tea leaves, and various drinks that have been expected to have an arousal effect have been on the market for a long time. In recent years, focusing on its central action, human cognition has been achieved through the combined use with carbonic anhydrase activator (see Patent Document 1) and with theanine component contained in tea leaves (see Patent Document 2). Techniques have been disclosed to increase ability and attention concentration. Similarly, in combination with the component epicatechin contained in tea leaves, a technique for providing a relaxation effect on mental fatigue has been disclosed (see Patent Document 3). And after combining caffeine and a tea leaf component, it is clarified that the combined use of a specific amino acid brings about relaxation of mental fatigue and maintenance of concentration (see Patent Document 4). . However, these technologies only improve recovery of cognitive ability and attention concentration by relieving and reducing mental functions in a fatigued state, and more advanced thinking activities such as mathematical operations in healthy people. It has not yet been shown to improve the ability to

Special table 2005-526065 JP 2006-153898 A JP2002-80363 JP 2002-322063 A

The present inventors have aimed to improve the ability of advanced thinking activities in the brain, such as mathematical operations. That is, it was considered that the mental fatigue recovery improvement effect in a fatigue state derived from a combination of conventional caffeine and tea leaf components is not sufficient. The present invention provides a liquid composition excellent in the effect of improving the computing ability, not only improving the recovery of cognitive ability and attention concentration, but also leading the brain consciousness level to a relaxed state more actively in a healthy person. With the goal.

  The inventors of the present invention have been diligently researching a liquid composition that leads brain activity to a relaxed state in a healthy person and improves the ability of more advanced thinking activities. As a result, by adding a yellow extract derived from a lily family plant to caffeine, the present inventors have found a liquid composition that can effectively improve the computing ability, and have completed the present invention.

The present invention relates to the provision of a liquid composition comprising a combination of caffeine and a yellow extract derived from a lily family plant Narcoli.

According to the present invention, in the liquid composition, the brain consciousness level of a healthy person is brought into a relaxed state by combining caffeine with a yellow spirit extract derived from the lily family plant Narcoli, and at the same time, the computing ability is improved. Is possible.

Polygonati Rhizoma as a starting material of Polygonati Rhizoma extract used in the present invention is the rhizome of a plant Narukoyuri the Liliaceae (Liliaceae) (Polygonatum f alcatum) , mainly Chinese mainland various Ministry or autonomous regions of Yangtze basin north (Heilongjiang , Jilin, Liaoning, Hebei, Shandong, Jiangsu, Henan, Shanxi, Shaanxi, Inner Mongolia).

  As for yellow spirit, dried and pulverized one can be used as it is, but an extract extracted with a solvent or the like can also be used. At the time of extraction, it may be used as it is, but considering the extraction efficiency, it is desirable to perform the extraction after performing processing such as shredding, drying, and pulverization. The extraction can be performed by a general method such as a method of immersing in an extraction solvent or an extraction method using a supercritical fluid or the like. The extraction temperature is preferably about 5 ° C. to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but is preferably about 1 hour to 14 days.

  Examples of the extraction solvent include organic compounds such as water, methanol, ethanol and other lower alcohols, glycerin, propylene glycol, polyhydric alcohols such as 1,3-butylene glycol, esters such as ethyl acetate, and ketones such as acetone. Solvents or mixtures thereof can be used.

  The obtained extract can be used as it is, but the concentrated and dried product is dissolved again in water or a solvent, or purification treatment such as decolorization, deodorization, and desalting is performed without impairing these actions. Or after fractionation by column chromatography. For storage, it can be freeze-dried after purification and dissolved in a solvent when used.

  The blending amount of the yellow extract used in the present invention may be 0.1 w / w% or more of the whole liquid composition, but if the blending amount exceeds 10 w / w%, problems such as generation of bubbles at the time of preparation occur. It becomes easy. Therefore, the blending amount of the yellow extract used in the present invention is more preferably 0.1 w / w% to 10 w / w%.

  The present invention can exhibit further effects by further blending other herbal medicines.

  The herbal medicine that can be used in the present invention is preferably one or more selected from the group consisting of chrysanthemum, ginseng, tea, and guarana.

Next, the caffeine used in the present invention contains a lot of caffeine such as tea leaves ( Thea sinensis ) and guarana ( Paulinia cupana ) which are marketed as food and drink products, in addition to those marketed as raw materials for pharmaceuticals. An extract of a plant known in the art can be arbitrarily used.

  In the liquid composition of the present invention, ingredients that can be used in normal liquid preparations, for example, vitamins, amino acids, organic acids, herbal medicines, sweeteners, fragrances, preservatives, etc., nutrition enhancing ingredients, nourishing tonic ingredients Etc. can be selected and blended in a timely manner, and can be produced by a conventional method for producing a liquid preparation.

Below, the relaxation effect of the composition of this invention and the calculation capability improvement effect were confirmed by the drink composition and the Example which were shown to the following preparation examples. In addition, this invention is not restrict | limited at all by these Examples.

Preparation Example: A beverage composition test beverage (each 50 mL) was prepared according to the formulation shown in Table 1. Each beverage contains 150 mg of caffeine (Comparative Example 1), 100 mg of yellow extract (Comparative Example 2), 150 mg of caffeine and 100 mg of yellow extract (Test Example 1). Furthermore, a placebo containing neither caffeine nor yellow extract was prepared (Comparative Example 3).

  Each test beverage was tested for relaxation effect and computational performance improvement effect.

Example 1: Measurement of brain waves The brain waves generated with the action of the cerebrum are classified into four types according to the frequency and amplitude, and the state of consciousness of the brain can be measured and known from the appearance frequency of each brain wave. An α wave with a frequency of 8 to 13 Hz indicates a conscious state of relaxation or meditation, a β wave with a frequency of 14 to 30 Hz indicates a tension state, a γ wave with a frequency of 0.5 to 3 Hz indicates an unconscious state such as deep sleep, and the frequency 4 A θ wave of ˜7 hertz is regarded as an index indicating a state of consciousness of stagnation.

  For the test, a simple electroencephalogram measuring device Mind Navi (manufactured by Hitachi VLSI Systems) was used. In an environment where the subject was able to maintain a resting state, the frequency of appearance of α waves before and after the drinking of each beverage was recorded, and the amount of change was used to evaluate the effect of inducing relaxation by drinking. The results are shown in FIG.

As shown in FIG. 1, in the test beverage (Comparative Example 2) containing only the placebo (Comparative Example 3) and the yellow extract, no obvious change was observed in the frequency of appearance of α waves due to drinking, only the yellow extract Then, it showed that it does not bring about the increase of alpha wave. On the other hand, test drinks containing caffeine (Test Example 1 and Comparative Example 1) showed an increase in alpha waves after drinking, that is, an induction effect on a relaxed state of brain consciousness. In the test beverage containing both of the products (Test Example 1), the expression of the effect was remarkable, and it was shown that the extract of yellow spirit further enhances the α-wave enhancing effect of caffeine.

Example 2: Evaluation of computing ability The computing ability was evaluated by calculating one hundred squares within a certain period of time. As shown in FIG. 2, the hundred-mass calculation is performed by adding 10 columns × 10 rows using a grid-like sheet in which 10 numbers of 0 to 9 are arranged vertically and horizontally. The result is entered in a predetermined square. In addition, the arrangement of numbers was changed randomly for each sheet.

  The subject was asked to perform as many hundreds of calculations as possible during each 10 minutes before and after drinking the test beverage, and the improvement effect of the computing ability by drinking was evaluated with the number of answers and the correct answer rate. The results are shown in FIGS.

  As shown in FIG. 3, in the test beverage (Comparative Example 2) containing only the placebo (Comparative Example 3) and the yellow extract, the increase in the number of responses due to drinking was not observed. It was shown that there was no effect to increase. On the other hand, in the test beverages containing caffeine (Test Example 1, Comparative Example 1), an increase in the number of responses due to drinking was observed. In particular, in the test drink containing both caffeine and yellow extract (Test Example 1), a more remarkable increase in the number of responses was observed, and the yellow extract further strengthened the effect of increasing the number of responses due to drinking caffeine. I showed that.

  FIG. 4 shows the correct answer rate, but no decrease in the correct answer rate is observed in any of the test beverages. That is, the increase in the number of responses by drinking the test beverage containing caffeine is not simply an increase in the number of rough responses induced by the known central excitatory action of caffeine, but without compromising calculation accuracy. Clarified that the number increased.

  As described above, drinking caffeine induces the brain's level of consciousness to an ideal relaxed state for advanced thinking activities, and at the same time, brings about an effect of improving effective computing ability. It was found that it was further enhanced by combined use with yellow extract.

If the composition for oral use of this invention is used, the formulation which has the improvement effect of the outstanding computing ability can be obtained. Further, the oral composition of the present invention has no worries about side effects and can be used as a soft drink or drink that can be used on a daily basis, and can be used as a pharmaceutical, quasi-drug, dietary supplement, health food. Can be used as

It is the figure which showed the induction | guidance | derivation to the relaxation state of the brain consciousness level shown in Example 1. FIG. Hundred squares calculation sheet used in Example 2 It is the figure which showed the increase in the number of answers shown in Example 2. FIG. It is the figure which showed the presence or absence of the influence on the correct answer rate shown in Example 2. FIG.

Claims (3)

A liquid composition comprising a yellow extract derived from caffeine and a lily family plant Narcoli. An α wave enhancer comprising a yellow extract derived from caffeine and a lily family plant Narcoli. A computing capacity improver comprising a yellow spirit extract derived from caffeine and a lily family plant Narcoli.

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