JP2008037802A - Teeth-whitening method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a teeth-whitening means having an excellent whitening effect. <P>SOLUTION: The teeth-whitening method comprises treating the surface of teeth simultaneously or alternately with monofluorophosphoric acid or its salt and an acid having a buffering action at a pH of 4-5.5. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a method for whitening teeth.

As means for whitening teeth, physical polishing, chemical bleaching with an oxidizing agent, blending of a component having a whitening effect, and the like are performed. Of these, physical polishing and chemical bleaching are performed by a dentist or a dental hygienist, and thus cannot be performed at home on a daily basis. On the other hand, as an oral composition containing a whitening component, a dentifrice containing polyethylene glycol or phytic acid (Patent Documents 1 and 2), a whitening patch containing ascorbic acid or a salt thereof (Patent Document) 3) Dentifrices (Patent Documents 4 to 6) containing water-soluble polyphosphates are known.
JP 56-18911 A Japanese Patent Laid-Open No. 56-18913 Japanese Patent Laid-Open No. 10-17448 JP 9-175966 A Japanese Patent Laid-Open No. 10-182389 JP 9-175966 A

However, the whitening effect obtained by using a dentifrice or a whitening patch containing these whitening ingredients is not sufficient, and the effect of strengthening the tooth quality such as acid resistance is low, resulting in a more excellent whitening effect. A means for whitening teeth has been desired.
Accordingly, an object of the present invention is to provide a new tooth whitening means having an excellent whitening effect and a tooth strengthening effect.

  The present inventor has been variously examined about the effect of promoting recalcification of teeth and the effect of fluorine uptake into teeth, etc., although monofluorophosphoric acid or a salt thereof, although the effect of fluorine uptake into teeth alone is not so strong, When this is treated with an acid having a buffer capacity at pH 4 to 5.5 or alternately, the tooth surface is surprisingly excellent in the effect of whitening the tooth from the inside, and further strengthens the tooth quality. It discovered that an effect could also be provided.

  That is, the present invention provides a method for whitening teeth, wherein the tooth surface is treated simultaneously or alternately with monofluorophosphoric acid or a salt thereof and an acid having a buffering action at pH 4 to 5.5. Is.

  According to the method of the present invention, the teeth become white from the inner surface, become beautiful white teeth with the original transparency of the tooth without losing the gloss of the surface of the teeth, and the teeth are strengthened to obtain teeth that are difficult to become decayed teeth. be able to. In addition, the method of the present invention can be easily implemented at home.

  The tooth whitening method of the present invention comprises treating monofluorophosphoric acid or a salt thereof (hereinafter referred to as MFP or the like) and an acid having a buffering action in a pH range of 4 to 5.5 simultaneously or alternately. Done. Here, in the case of “processing at the same time”, it is preferable to process with a composition having a pH of 4 to 5.5 containing MFP or the like. On the other hand, in the case of “alternating treatment”, the composition containing MFP or the like and the composition containing an acid having a buffering action in the pH range of 4 to 5.5 are used in order. Is preferred. It should be noted that such an effect cannot be obtained with a composition containing MFP or the like and having a pH of 6 or higher. In addition, when a composition having a pH of less than 4 is used, the dissolution of teeth by acid is prioritized and tends to be an environment that induces the progress of cavity, and the whiteness of teeth is obtained, but the gloss of the teeth tends to be impaired. is there.

  Examples of the salt of monofluorophosphoric acid include sodium monofluorophosphate, potassium monofluorophosphate, magnesium monofluorophosphate, calcium monofluorophosphate, etc., but sodium monofluorophosphate, potassium monofluorophosphate, monofluoro Calcium phosphate is particularly preferred.

As an acid that can provide a buffering action in a pH range of 4 to 5.5, an organic acid having a pKa of 2.5-6 is preferable, and an acid having a pKa of 3-5.5 is particularly preferable. For example, monobasic acids such as formic acid, acetic acid, propionic acid; dibasic acids such as oxalic acid, succinic acid, adipic acid, fumaric acid, maleic acid; glycolic acid, lactic acid, tartaric acid, malic acid, citric acid, ascorbic acid, etc. Hydroxycarboxylic acid; acidic amino acids such as glutamic acid and aspartic acid; keto acids such as levulinic acid; aromatic carboxylic acids such as benzoic acid and salicylic acid. Among these, at least one selected from lactic acid, acetic acid, citric acid, malic acid, succinic acid, tartaric acid and adipic acid is preferable, and lactic acid, acetic acid, malic acid, and citric acid are particularly preferable from the viewpoint of acting as a calcium source.
Phosphoric acid is a constituent of teeth, and it is preferable to use phosphoric acid and its salt in combination with the above-mentioned acid, since the whitening effect can be easily controlled. As the salt of phosphoric acid, sodium and potassium salts are preferable. In addition to phosphoric acid, glycerophosphoric acid, glucose-1-phosphate and salts thereof can also be used.

  In the whitening method of the present invention, the composition used for “processing at the same time” is a mixture of MFP or the like and the acid of pKa2.5-6, and the pH of the composition is 4 to 5.5. Compositions are preferred.

  The content of MFP or the like in the composition is preferably 0.01 to 20% by mass, more preferably 0.1 to 5% by mass, particularly preferably 0.3 to 1% by mass from the viewpoint of whitening effect and strengthening of the tooth structure. The acid content of pKa2.5-6 in the composition is preferably from 0.1 to 30% by mass, more preferably from 0.2 to 10% by mass, particularly preferably from 0.5 to 5% by mass, from the viewpoint of the whitening effect. .

  The composition of the present invention can contain a fluorine supplying compound (other than MFP or the like) such as sodium fluoride within a range that does not affect the effects of the present invention, that is, the whitening effect by MFP or the like and the strengthening of the tooth structure. The blending amount of the fluorine supply compound is preferably 1/2 or less in terms of a molar ratio with respect to MFP or the like from the viewpoint of not inhibiting the penetration of teeth such as MFP. Specifically, the compounding amount of the fluorine supplying compound is a molar ratio with respect to the MFP or the like in the composition for simultaneous processing (coexistence of MFP and the acid) or in the composition containing MFP or the like when alternately processing. In the composition containing an acid when alternately processed, it is preferably 0.025 mol / l or less. When the fluorine supply compound is a compound that easily forms a calcium fluoride layer such as sodium fluoride, the fluorine supply compound is not blended with the MFP, etc. due to the relationship between the penetration of the MFP and the formation of the calcium fluoride layer. It is preferable. In the present invention, it is preferable that the composition containing MFP or the like does not contain a fluorine supply compound.

  Each of the above compositions may contain other whitening ingredients, calcium source, wetting agent, binder, sugar alcohol, flavoring agent, sweetener, preservative, bactericidal agent, surfactant, water and the like. it can. Examples of other whitening components include ascorbic acid or a salt thereof, water-soluble polyphosphoric acid, polyethylene glycol, and the like. As the calcium source, calcium salts such as hydrochloric acid, nitric acid, sulfuric acid and the like are included, and it is particularly preferable to use them together under the use of an acid capable of obtaining the buffer action of the present invention.

  Examples of the wetting agent include glycerin, sorbitol, polyethylene glycol, propylene glycol, ethylene glycol, 1,3-butylene glycol, polypropylene glycol, maltitol, lactitol, and the like. Can do.

  Examples of the binder include cellulose derivatives such as carrageenan, pectin, carboxymethylcellulose sodium, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, alkali metal alginates such as sodium alginate, xanthan gum, tragacanth gum, gum arabic, guar gum, caraya gum, Water-soluble polymers selected from gums such as locust bean gum, gellan gum, tamarind gum and psyllium seed gum, synthetic binders such as polyvinyl alcohol, sodium polyacrylate and polyvinylpyrrolidone, and inorganic such as silica gel and aluminum silica gel A binder is mentioned. These binders may be used alone or in combination of two or more.

  Examples of the sugar alcohol include erythritol, xylitol, sorbitol and the like in addition to the components described as the wetting agent.

  As flavoring agents, l-menthol, carvone, anethole, eugenol, limonene, peppermint oil, spearmint oil, osimene, n-amyl alcohol, citronellol, α-terpineol, methyl salicylate, methyl acetate, citronole acetate, cineol, linalool , Ethyl linalool, crocodile, thymol, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, perilla oil, clove oil, eucalyptus oil, peppermint oil, anise oil, winter green oil and the like.

  Examples of the sweetener include saccharin sodium, aspartame, sucralose, thaumatin, acesulfame potassium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartin, dextrose, acesulfame and the like.

In the method of the present invention, the means for treating the tooth surface includes a means for applying each of the compositions to the tooth surface. Also, from the viewpoint of obtaining an excellent tooth whitening effect, it is preferable that the MFP and the acid are present on the tooth surface for 5 seconds to 10 hours, and more preferably for 30 seconds to 5 hours.
Here, if the MFP adheres to the tooth surface, it can be treated for 5 seconds to 30 minutes even if it is rinsed with water, so it can be treated for 5 seconds to 30 minutes. Since it tends to flow out from the surface, it is preferable to be present for 10 minutes to 10 hours, and further for 30 minutes to 5 hours. In order to keep these components on the surface of the tooth for such a time, the viscosity of each composition is preferably 500 to 10000 dPa · s, more preferably 1000 to 5000 dPa · s. Moreover, when the viscosity is 100 dPa · s or less, the absorbent material such as absorbent cotton, non-woven fabric and sponge can be soaked and act on the tooth surface.

  As a means for applying each composition to the tooth surface, in addition to a method of applying the composition with a cotton ball, fingers, brushes, etc., each composition described above is applied to a tray (dental tray) for application to teeth. Means for putting objects and attaching the tray to the teeth can be mentioned.

  In the case of alternately processing with MFP or the like and the acid, it is preferable to perform the process with MFP or the like for 10 seconds to 30 minutes, and then perform the treatment with acid for 10 minutes to 10 hours, particularly 30 minutes to 5 hours.

  The coating amount of each composition is preferably 0.5 to 20 g per one time. Furthermore, the treatment according to the present invention is preferably continued once a day for 2 to 30 days.

Example 1 and Comparative Example 1
Ordinarily remove the dirt and plaque attached to the teeth. Thereafter, the gel composition 1 shown in Table 1 is added to the tray for adapting to the teeth (FIG. 1), attached to the teeth so that air does not enter (FIG. 2), and held for 2 hours. Remove the tray and remove the gel remaining on the tooth surface by mouthwash. This is carried out once / day for 10 days, and the tooth surface before and after the test is observed. As a comparative example, the same treatment is performed using a comparative gel composition 1 (pH 6) in which the pH is adjusted to 6.0 in the formulation of Table 1.
The surface of the teeth treated with the gel composition 1 had white teeth, high transparency, and white from the inside. On the other hand, the tooth surface treated with the comparative gel composition 1 (pH 6) does not provide sufficient tooth whitening effect.

Example 2 and Comparative Example 2
Take 1 g or more of the gel composition 2-1 (Table 2) on a toothbrush and apply it evenly for 2 minutes around the front teeth. After lightly rinsing with water, the gel composition 2-2 (Table 3) is placed in the tray of FIG. 1 and attached to the teeth so that air does not enter, and held for 2 hours. Remove the tray and remove the gel remaining on the tooth surface by mouthwash. This is performed once / day for 10 days, and the tooth surface before and after the test is observed. As a comparative example, the same treatment is performed after the gel-like composition 2-1, using a comparative gel-like composition 2-2 (pH 7) adjusted to pH 7.0 with the formulation of Table 3.
The surface of the tooth treated with the gel composition 2-2 had white teeth, high transparency, and white from the inside. On the other hand, even if the same treatment is performed using the comparative gel composition 2-2 (pH 7), sufficient whitening effect of the teeth cannot be obtained.

Example 3
To confirm the tooth strengthening action, the solubility (acid resistance) of the tooth was measured.
Six bovine teeth were prepared, and the same processing as in Example 1 and Comparative Example 1, and in Example 2 and Comparative Example 2 was performed. During the time when the treatment was not performed, the sample was immersed in a progressive saliva (Salibate, manufactured by Teijin). Thereafter, the five samples including the untreated control group were immersed in a 0.1 M lactate buffer solution having a pH of 4.5 for 2 days. The teeth after the test were processed into 400 micron sections, and X-rays were taken. The tooth mineral elution amount (Z (vol% * μm)) was calculated from the photograph by a conventional method, and the difference from the untreated product was obtained polyoxyethylene C14-C18 alkyl phosphate ester Z (vol% * μm). It can be determined that the smaller the value of ΔZ, the more the tooth elution is suppressed and the tooth quality is strengthened. ΔZ was determined according to the following literature.
(Angmar B, Carlstrom D, Glas JE: Studies on the ultrastructure of dental enamel. IV The mineralization of normal human enamel.J Ultrastructure Res 8: 12-33, 1963, Gelhard TB, Arends J: Microradiography of in vivo remineralized lesions in human enamel. II.J Biol Buccale. 12 (1): 59-65, 1984). The results are shown in Table 4.

  As is clear from Table 4, the amount of mineral elution from the teeth was suppressed and the tooth quality was remarkably enhanced in the teeth treated by the method of the present invention.

It is a figure which shows an example of the tray for tooth mounting. It is a figure which shows the state which mounted | wore the tooth | gear with the tray.

Claims (3)

  A method for whitening teeth, comprising treating a tooth surface with monofluorophosphoric acid or a salt thereof and an acid having a buffering action at pH 4 to 5.5 simultaneously or alternately.   The whitening method according to claim 1, wherein the tooth surface is treated with a composition having a pH of 4 to 5.5 containing monofluorophosphoric acid or a salt thereof and an acid having a pKa of 2.5-6.   The tooth surface is alternately treated with a composition containing monofluorophosphoric acid or a salt thereof and a composition having a pH of 4 to 5.5 containing an acid having a pKa of 2.5-6. Teeth whitening method.