JP2007532599A - Ｍｃｈ拮抗作用を示す新規アルキン化合物及び該化合物を含む医薬 - Google Patents

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Publication number

JP2007532599A

JP2007532599A JP2007507719A JP2007507719A JP2007532599A JP 2007532599 A JP2007532599 A JP 2007532599A JP 2007507719 A JP2007507719 A JP 2007507719A JP 2007507719 A JP2007507719 A JP 2007507719A JP 2007532599 A JP2007532599 A JP 2007532599A

Authority

JP

Japan

Prior art keywords

alkyl

group

phenyl

cycloalkyl

atoms

Prior art date

2004-04-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 55
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• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 32
• 125000004076 pyridyl group Chemical group 0.000 claims description 30
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 29
• KZOWNALBTMILAP-JBMRGDGGSA-N ancitabine hydrochloride Chemical compound Cl.N=C1C=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3OC2=N1 KZOWNALBTMILAP-JBMRGDGGSA-N 0.000 claims description 29
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 29
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• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
• 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 6
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• 125000002541 furyl group Chemical group 0.000 claims description 6
• 239000008103 glucose Substances 0.000 claims description 6
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 6
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• VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 5
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• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 5
• 125000003341 7 membered heterocyclic group Chemical group 0.000 claims description 4
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 4
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• YHSDVOFXUQAAAF-UHFFFAOYSA-N 6-[2-[5-(4-chlorophenyl)pyridin-2-yl]ethynyl]-2-(pyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydroquinoline Chemical compound C1=CC(Cl)=CC=C1C1=CC=C(C#CC=2C=C3CCC(CN4CCCC4)NC3=CC=2)N=C1 YHSDVOFXUQAAAF-UHFFFAOYSA-N 0.000 claims description 3
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