JP2007532594A - Ｍｃｈ拮抗作用を有する新規アルキン化合物及び前記化合物を含む医薬 - Google Patents

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Publication number

JP2007532594A

JP2007532594A JP2007507707A JP2007507707A JP2007532594A JP 2007532594 A JP2007532594 A JP 2007532594A JP 2007507707 A JP2007507707 A JP 2007507707A JP 2007507707 A JP2007507707 A JP 2007507707A JP 2007532594 A JP2007532594 A JP 2007532594A

Authority

JP

Japan

Prior art keywords

alkyl

group

phenyl

groups

amino

Prior art date

2004-04-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 125000004432 carbon atom Chemical group C* 0.000 claims description 75
• 101800002739 Melanin-concentrating hormone Proteins 0.000 claims description 60
• 229910052794 bromium Inorganic materials 0.000 claims description 60
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 56
• 150000003839 salts Chemical class 0.000 claims description 55
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• KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 34
• 125000004122 cyclic group Chemical group 0.000 claims description 34
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 34
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• 125000004076 pyridyl group Chemical group 0.000 claims description 32
• KZOWNALBTMILAP-JBMRGDGGSA-N ancitabine hydrochloride Chemical compound Cl.N=C1C=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3OC2=N1 KZOWNALBTMILAP-JBMRGDGGSA-N 0.000 claims description 29
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• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 5
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 5
• 125000003386 piperidinyl group Chemical group 0.000 claims description 5
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• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 4
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