JP2007527909A5 - - Google Patents
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- Publication number
- JP2007527909A5 JP2007527909A5 JP2007502940A JP2007502940A JP2007527909A5 JP 2007527909 A5 JP2007527909 A5 JP 2007527909A5 JP 2007502940 A JP2007502940 A JP 2007502940A JP 2007502940 A JP2007502940 A JP 2007502940A JP 2007527909 A5 JP2007527909 A5 JP 2007527909A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- cycloalkyl
- optionally substituted
- substituents
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001424 substituent group Chemical group 0.000 claims 67
- 125000000217 alkyl group Chemical group 0.000 claims 63
- 229910052736 halogen Inorganic materials 0.000 claims 46
- 150000002367 halogens Chemical class 0.000 claims 46
- 125000000753 cycloalkyl group Chemical group 0.000 claims 42
- 125000003118 aryl group Chemical group 0.000 claims 35
- 125000001072 heteroaryl group Chemical group 0.000 claims 35
- 125000000623 heterocyclic group Chemical group 0.000 claims 31
- -1 perfluoro Chemical group 0.000 claims 28
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 229920001774 Perfluoroether Polymers 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 7
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 claims 6
- 125000001589 carboacyl group Chemical group 0.000 claims 6
- XNVMFDGFXSZPDU-UHFFFAOYSA-N cyano nitroformate Chemical compound [O-][N+](=O)C(=O)OC#N XNVMFDGFXSZPDU-UHFFFAOYSA-N 0.000 claims 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 6
- 125000004438 haloalkoxy group Chemical group 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000004663 dialkyl amino group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 0 *[n]1c(S)ncc1**[Al] Chemical compound *[n]1c(S)ncc1**[Al] 0.000 description 9
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55147204P | 2004-03-08 | 2004-03-08 | |
| US55139504P | 2004-03-08 | 2004-03-08 | |
| US55147304P | 2004-03-08 | 2004-03-08 | |
| US55137204P | 2004-03-08 | 2004-03-08 | |
| US55162004P | 2004-03-08 | 2004-03-08 | |
| US55151004P | 2004-03-08 | 2004-03-08 | |
| US55147404P | 2004-03-08 | 2004-03-08 | |
| US55150304P | 2004-03-08 | 2004-03-08 | |
| US55148004P | 2004-03-08 | 2004-03-08 | |
| PCT/US2005/007667 WO2005086836A2 (en) | 2004-03-08 | 2005-03-07 | Ion channel modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007527909A JP2007527909A (ja) | 2007-10-04 |
| JP2007527909A5 true JP2007527909A5 (https=) | 2008-04-24 |
Family
ID=34976180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007502940A Pending JP2007527909A (ja) | 2004-03-08 | 2005-03-07 | イオンチャンネルモジュレーター |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070281937A1 (https=) |
| EP (1) | EP1723117A4 (https=) |
| JP (1) | JP2007527909A (https=) |
| AU (1) | AU2005220911A1 (https=) |
| BR (1) | BRPI0508532A (https=) |
| CA (1) | CA2557637A1 (https=) |
| WO (1) | WO2005086836A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070191448A1 (en) * | 2004-03-08 | 2007-08-16 | Robert Zelle | Ion channel modulators |
| AU2005221683A1 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
| EP1723123A4 (en) * | 2004-03-08 | 2009-12-02 | Wyeth Corp | ION CHANNEL MODULATORS |
| US20080139560A1 (en) * | 2004-03-08 | 2008-06-12 | Scion Pharmaceuticals, Inc. | Ion Channel Modulators |
| WO2005087747A1 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
| AU2005221128A1 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
| EP1722783A4 (en) * | 2004-03-08 | 2009-08-12 | Wyeth Corp | MODULATORS OF THE ION CHANNEL FUNCTION |
| DE102006024024A1 (de) | 2006-05-23 | 2007-11-29 | Bayer Healthcare Aktiengesellschaft | Substituierte Arylimidazolone und -triazolone sowie ihre Verwendung |
| TWI386405B (zh) | 2006-09-05 | 2013-02-21 | 咪唑衍生物 | |
| WO2009102893A2 (en) | 2008-02-14 | 2009-08-20 | Amira Pharmaceuticals, Inc. | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors |
| US8426449B2 (en) | 2008-04-02 | 2013-04-23 | Panmira Pharmaceuticals, Llc | Aminoalkylphenyl antagonists of prostaglandin D2 receptors |
| US8383654B2 (en) | 2008-11-17 | 2013-02-26 | Panmira Pharmaceuticals, Llc | Heterocyclic antagonists of prostaglandin D2 receptors |
| DE102008060967A1 (de) | 2008-12-06 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylsulfonyltriazolone und ihre Verwendung |
| DE102010001064A1 (de) | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
| IN2012DN01693A (https=) | 2009-08-26 | 2015-06-05 | Novartis Ag | |
| UA109650C2 (xx) | 2010-02-27 | 2015-09-25 | Біс-арилзв'язані арилтриазолони та їх застосування | |
| DE102010040187A1 (de) | 2010-09-02 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Substituierte N-Phenethyl-triazolonacetamide und ihre Verwendung |
| DE102010040924A1 (de) | 2010-09-16 | 2012-03-22 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylacet- und Phenylpropanamide und ihre Verwendung |
| AU2011307289A1 (en) | 2010-09-29 | 2013-02-21 | E. I. Du Pont De Nemours And Company | Fungicidal imidazoles |
| US8703776B2 (en) * | 2011-06-15 | 2014-04-22 | Cymabay Therapeutics, Inc. | Agonists of GPR131 and uses thereof |
| WO2013032939A1 (en) | 2011-08-26 | 2013-03-07 | Metabolex, Inc. | Bicyclic agonists of gpr131 and uses thereof |
| SG10201802911RA (en) | 2013-03-15 | 2018-05-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| EA202092627A1 (ru) | 2013-11-18 | 2021-09-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| SI3215498T1 (sl) | 2014-11-03 | 2018-11-30 | Bayer Pharma Aktiengesellschaft | Hidroksialkil-substituirani derivati feniltriazola in njihove uporabe |
| US10882841B2 (en) | 2016-03-01 | 2021-01-05 | University Of Maryland, Baltimore | Wnt signaling pathway inhibitors for treatments of disease |
| US9988367B2 (en) | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ238688A (en) * | 1990-06-28 | 1992-05-26 | Smithkline Beecham Corp | Substituted histidines: pharmaceutical compositions, preparation and uses thereof |
| EP1722783A4 (en) * | 2004-03-08 | 2009-08-12 | Wyeth Corp | MODULATORS OF THE ION CHANNEL FUNCTION |
| AU2005221683A1 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
-
2005
- 2005-03-07 WO PCT/US2005/007667 patent/WO2005086836A2/en not_active Ceased
- 2005-03-07 AU AU2005220911A patent/AU2005220911A1/en not_active Abandoned
- 2005-03-07 US US10/592,451 patent/US20070281937A1/en not_active Abandoned
- 2005-03-07 EP EP05725050A patent/EP1723117A4/en not_active Withdrawn
- 2005-03-07 JP JP2007502940A patent/JP2007527909A/ja active Pending
- 2005-03-07 BR BRPI0508532-2A patent/BRPI0508532A/pt not_active IP Right Cessation
- 2005-03-07 CA CA002557637A patent/CA2557637A1/en not_active Abandoned
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