JP2007526480A - 応力に基づく化学反応の静電測定 - Google Patents
応力に基づく化学反応の静電測定 Download PDFInfo
- Publication number
- JP2007526480A JP2007526480A JP2007501916A JP2007501916A JP2007526480A JP 2007526480 A JP2007526480 A JP 2007526480A JP 2007501916 A JP2007501916 A JP 2007501916A JP 2007501916 A JP2007501916 A JP 2007501916A JP 2007526480 A JP2007526480 A JP 2007526480A
- Authority
- JP
- Japan
- Prior art keywords
- diaphragm
- sensor
- analyte
- selective coating
- capacitance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/22—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
- G01N27/227—Sensors changing capacitance upon adsorption or absorption of fluid components, e.g. electrolyte-insulator-semiconductor sensors, MOS capacitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/02—Indexing codes associated with the analysed material
- G01N2291/028—Material parameters
- G01N2291/02863—Electric or magnetic parameters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
- G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/806—Electrical property or magnetic property
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Power Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Measuring Fluid Pressure (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
【選択図】なし
Description
Claims (21)
- 選択性材料との結合又は反応を検出する方法であって:
a.i.導電性部を含むダイアフラム、
ii.前記ダイアフラムの第1表面上の選択性コーティング、及び
iii.前記ダイアフラムの向かいに隔置された対向電極、
を含むセンサを設けるステップであって、前記選択性コーティングと分析物との相互作用によって前記ダイアフラムが変形し、それによって前記センサの静電容量が変化する、ステップと、
b.前記センサの静電容量を測定して、前記分析物と前記選択性コーティングとの相互作用の度合を決定するステップと、
を包含する、方法。 - 前記ダイアフラムの全体が導電性である、請求項1に記載の方法。
- 前記ダイアフラムの組成が均一である、請求項1に記載の方法。
- 前記測定ステップが、参照静電容量と前記センサの静電容量とを比較することを包含する、請求項1に記載の方法。
- 前記参照静電容量が、前記選択性コーティングへの相互作用がない場合の前記センサの静電容量に等しい、請求項4に記載の方法。
- 前記選択性コーティングが、ポリペプチドを含む、請求項1に記載の方法。
- 前記選択性コーティングが、抗体を含む、請求項1に記載の方法。
- 前記選択性コーティングが、抗原を含む、請求項1に記載の方法。
- 流体に少なくとも前記選択性コーティングを露出するステップをさらに包含し、前記測定ステップが、前記コーティングに結合する分析物が前記流体中に存在するか否かを示す、請求項1に記載の方法。
- 前記流体が、ガスを含む、請求項9に記載の方法。
- 前記流体が、液体を含む、請求項9に記載の方法。
- 前記変形が、結合の度合を示す結合エネルギーに比例する、請求項1に記載の方法。
- a.導電性部を含むダイアフラム、
b.前記ダイアフラムの第1表面上の選択性コーティング、及び
c.前記ダイアフラムの向かいに隔置された対向電極、
を含んで成るセンサであって、前記選択性コーティングと分析物との相互作用によって前記ダイアフラムが変形し、それによって相互作用の度合を示すように前記センサの静電容量が変化する、センサ。 - 前記ダイアフラムの全体が導電性である、請求項13に記載のセンサ。
- 前記ダイアフラムの組成が均一である、請求項13に記載のセンサ。
- 前記選択性コーティングが、前記ダイアフラムの前記第1表面の一部のみを覆っている、請求項13に記載のセンサ。
- 前記ダイアフラムの両面にかかる圧力を等しくするための手段をさらに含む、請求項13に記載のセンサ。
- 前記圧力を等しくする手段が、前記対向電極を貫通する穴を含む、請求項17に記載のセンサ。
- 前記コーティングが、前記ダイアフラムの前記第1表面の中半分を覆っている、請求項13に記載のセンサ。
- 前記分析物の存在を報告する回路をさらに含む、請求項13に記載のセンサ。
- 前記分析物の濃度を報告する回路をさらに含む、請求項13に記載のセンサ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/791,108 | 2004-03-02 | ||
US10/791,108 US7402425B2 (en) | 2004-03-02 | 2004-03-02 | Stress-based electrostatic monitoring of chemical reactions and binding |
PCT/US2005/006680 WO2005085856A1 (en) | 2004-03-02 | 2005-03-02 | Stress-based electrostatic monitoring of chemical reactions |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007526480A true JP2007526480A (ja) | 2007-09-13 |
JP4913032B2 JP4913032B2 (ja) | 2012-04-11 |
Family
ID=34911598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007501916A Expired - Fee Related JP4913032B2 (ja) | 2004-03-02 | 2005-03-02 | 応力に基づく化学反応の静電測定 |
Country Status (5)
Country | Link |
---|---|
US (1) | US7402425B2 (ja) |
EP (1) | EP1723421A1 (ja) |
JP (1) | JP4913032B2 (ja) |
CN (1) | CN1947015A (ja) |
WO (1) | WO2005085856A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011519033A (ja) * | 2008-04-23 | 2011-06-30 | バイオスケール, インコーポレイテッド | 検体処理のための方法および装置 |
JP2019056607A (ja) * | 2017-09-20 | 2019-04-11 | 株式会社東芝 | ガスセンサおよびその製造方法 |
JP2019100705A (ja) * | 2017-11-28 | 2019-06-24 | 株式会社東芝 | ガスセンサ |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008157325A2 (en) * | 2007-06-15 | 2008-12-24 | Charles Stark Draper Laboratory, Inc. | Devices, systems, and methods for measuring glucose |
TW200913175A (en) * | 2007-09-05 | 2009-03-16 | Long-Sun Huang | Package structure for micro-sensor |
WO2009129351A2 (en) * | 2008-04-15 | 2009-10-22 | Regents Of The University Of Minnesota | Stiffness sensor |
US8181531B2 (en) * | 2008-06-27 | 2012-05-22 | Edwin Carlen | Accessible stress-based electrostatic monitoring of chemical reactions and binding |
US9011670B2 (en) * | 2008-08-14 | 2015-04-21 | The Charles Stark Draper Laboratory, Inc. | Three-dimensional metal ion sensor arrays on printed circuit boards |
US9140667B2 (en) * | 2010-08-15 | 2015-09-22 | Vlad Novotny | Chemical and biomedical NanoSensors |
DE102010040723B4 (de) * | 2010-09-14 | 2016-01-21 | Siemens Aktiengesellschaft | Bereitstellung eines Wechselsignals |
KR101831365B1 (ko) | 2010-11-01 | 2018-02-22 | 카프센제 에이치비 | 커패시턴스를 측정하는 방법 |
US9448126B2 (en) * | 2014-03-06 | 2016-09-20 | Infineon Technologies Ag | Single diaphragm transducer structure |
KR101811214B1 (ko) * | 2015-05-29 | 2017-12-22 | 고려대학교 세종산학협력단 | 비정질 금속을 이용한 유연한 압력 센서와, 압력 및 온도를 동시에 감지하는 유연한 이중모드 센서 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003185665A (ja) * | 2001-10-23 | 2003-07-03 | Samsung Electronics Co Ltd | 相補分子間の結合検出方法およびその方法に利用されるせん断応力測定センサー |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3909185A1 (de) | 1989-03-21 | 1990-09-27 | Endress Hauser Gmbh Co | Kapazitiver drucksensor und verfahren zu seiner herstellung |
US5339051A (en) | 1991-12-09 | 1994-08-16 | Sandia Corporation | Micro-machined resonator oscillator |
US5262127A (en) | 1992-02-12 | 1993-11-16 | The Regents Of The University Of Michigan | Solid state chemical micro-reservoirs |
US5308649A (en) * | 1992-06-26 | 1994-05-03 | Polar Materials, Inc. | Methods for externally treating a container with application of internal bias gas |
US6673533B1 (en) * | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
US5571401A (en) | 1995-03-27 | 1996-11-05 | California Institute Of Technology | Sensor arrays for detecting analytes in fluids |
DE19610293C1 (de) | 1996-03-15 | 1997-07-31 | Fraunhofer Ges Forschung | Vorrichtung zur gekapselten Aufnahme eines Materials |
DE69922727T2 (de) | 1998-03-31 | 2005-12-15 | Hitachi, Ltd. | Kapazitiver Druckwandler |
US6167748B1 (en) | 1998-08-31 | 2001-01-02 | Lockheed Martin Energy Research Corporation | Capacitively readout multi-element sensor array with common-mode cancellation |
JP3339565B2 (ja) | 1998-09-29 | 2002-10-28 | 株式会社山武 | 圧力センサ |
DE60135092D1 (de) | 2000-01-31 | 2008-09-11 | Univ Texas | Tragbare vorrichtung mit einer sensor-array-anordnung |
CA2404137C (en) | 2000-03-20 | 2006-07-11 | The Charles Stark Draper Laboratory, Inc. | Flexural plate wave sensor and array |
US20030027351A1 (en) | 2001-08-02 | 2003-02-06 | Scott Manalis | Monitoring of chemical reactions using interdigital cantilevers |
US7000482B2 (en) | 2002-06-24 | 2006-02-21 | Mykrolis Corporation | Variable capacitance measuring device |
US7344678B2 (en) * | 2002-11-15 | 2008-03-18 | The Regents Of The University Of California | Composite sensor membrane |
WO2004052046A2 (en) | 2002-11-27 | 2004-06-17 | Northwestern University | Thin membrane transducer |
-
2004
- 2004-03-02 US US10/791,108 patent/US7402425B2/en not_active Expired - Fee Related
-
2005
- 2005-03-02 EP EP05724263A patent/EP1723421A1/en not_active Withdrawn
- 2005-03-02 CN CN200580012891.1A patent/CN1947015A/zh active Pending
- 2005-03-02 WO PCT/US2005/006680 patent/WO2005085856A1/en active Application Filing
- 2005-03-02 JP JP2007501916A patent/JP4913032B2/ja not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003185665A (ja) * | 2001-10-23 | 2003-07-03 | Samsung Electronics Co Ltd | 相補分子間の結合検出方法およびその方法に利用されるせん断応力測定センサー |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011519033A (ja) * | 2008-04-23 | 2011-06-30 | バイオスケール, インコーポレイテッド | 検体処理のための方法および装置 |
JP2019056607A (ja) * | 2017-09-20 | 2019-04-11 | 株式会社東芝 | ガスセンサおよびその製造方法 |
JP2019100705A (ja) * | 2017-11-28 | 2019-06-24 | 株式会社東芝 | ガスセンサ |
Also Published As
Publication number | Publication date |
---|---|
EP1723421A1 (en) | 2006-11-22 |
CN1947015A (zh) | 2007-04-11 |
US20050196877A1 (en) | 2005-09-08 |
US7402425B2 (en) | 2008-07-22 |
JP4913032B2 (ja) | 2012-04-11 |
WO2005085856A1 (en) | 2005-09-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4913032B2 (ja) | 応力に基づく化学反応の静電測定 | |
US6523392B2 (en) | Microcantilever sensor | |
US8349611B2 (en) | Resonant sensors and methods of use thereof for the determination of analytes | |
JP3910217B2 (ja) | 化学センサ | |
US6016686A (en) | Micromechanical potentiometric sensors | |
EP1185865B1 (en) | Detection method using a micromechanical antibody sensor | |
KR100975010B1 (ko) | 다중 크기 압전 마이크로 칸티레버 공진자 어레이를 이용한 물리센서 및 그 제작방법 | |
KR100583233B1 (ko) | 생체물질 측정 시스템 및 방법 | |
EP1066511A1 (en) | Micromechanical calorimetric sensor | |
US20150177196A1 (en) | Differential Humidity Sensor | |
JP2009533658A5 (ja) | ||
US20090014340A1 (en) | Devices, systems, and methods for measuring glucose | |
US8181531B2 (en) | Accessible stress-based electrostatic monitoring of chemical reactions and binding | |
Piedimonte et al. | Differential Impedance Sensing platform for high selectivity antibody detection down to few counts: A case study on Dengue Virus | |
Vasagiri et al. | A survey of MEMS cantilever applications in determining volatile organic compounds | |
Wang et al. | Design and optimization of laminated piezoresistive microcantilever sensors | |
US20140364325A1 (en) | Array of Sensors Functionalized with Systematically Varying Receptor Materials | |
JP2006343336A (ja) | テスト領域の非光学的な読み取り | |
US7730767B2 (en) | Micro-sensor for sensing chemical substance | |
US20050266472A1 (en) | Apparatus and method for detecting bio molecule using inductance device | |
Pachkawade | N/MEMS Biosensors: An Introduction | |
Piedimonte et al. | Digital count of antibodies through differential impedance for high-resolution immunosensing | |
Piedimonte et al. | Bio-Reconfigurable Differential Impedance Electronic Platform for Multiplex Biomarker Detection | |
Lee et al. | Techniques in MEMS devices for micro humidity sensors and their applications | |
Bhura | 3D Interdigitated Electrode Array (IDEA) Biosensor For Detection Of Serum Biomarker |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080303 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110308 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110608 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110615 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110908 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20111220 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120118 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150127 Year of fee payment: 3 |
|
LAPS | Cancellation because of no payment of annual fees |