JP2007520452A5 - - Google Patents
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- JP2007520452A5 JP2007520452A5 JP2006536844A JP2006536844A JP2007520452A5 JP 2007520452 A5 JP2007520452 A5 JP 2007520452A5 JP 2006536844 A JP2006536844 A JP 2006536844A JP 2006536844 A JP2006536844 A JP 2006536844A JP 2007520452 A5 JP2007520452 A5 JP 2007520452A5
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- Prior art keywords
- compound according
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- 150000001875 compounds Chemical class 0.000 claims 69
- 229910052760 oxygen Inorganic materials 0.000 claims 31
- 239000000203 mixture Substances 0.000 claims 25
- 229910052757 nitrogen Inorganic materials 0.000 claims 24
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- 239000003937 drug carrier Substances 0.000 claims 6
- 125000002837 carbocyclic group Chemical group 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 206010061218 Inflammation Diseases 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 206010052779 Transplant rejections Diseases 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- 230000004054 inflammatory process Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 208000036142 Viral infection Diseases 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004437 phosphorous atom Chemical group 0.000 claims 1
- -1 vinyl compound Chemical class 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 0 Cc(c(CO1)c2C1=O)c(*)c(*)c2O Chemical compound Cc(c(CO1)c2C1=O)c(*)c(*)c2O 0.000 description 12
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51425803P | 2003-10-24 | 2003-10-24 | |
| PCT/US2004/013143 WO2004096236A2 (en) | 2003-04-25 | 2004-04-26 | Immunomodulator phosphonate conjugates |
| PCT/US2004/013198 WO2004100960A2 (en) | 2003-04-25 | 2004-04-26 | Anti-inflammatory phosphonate compounds |
| PCT/US2004/013121 WO2004096235A2 (en) | 2003-04-25 | 2004-04-26 | Anti-cancer phosphonate analogs |
| PCT/US2004/013063 WO2004096286A2 (en) | 2003-04-25 | 2004-04-26 | Antiviral phosphonate analogs |
| PCT/US2004/013064 WO2004096287A2 (en) | 2003-04-25 | 2004-04-26 | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| PCT/US2004/035136 WO2005039552A2 (en) | 2003-10-24 | 2004-10-25 | Inosine monophosphate dehydrogenase inhibitors as phosphonate derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007520452A JP2007520452A (ja) | 2007-07-26 |
| JP2007520452A5 true JP2007520452A5 (US07794700-20100914-C00152.png) | 2007-12-06 |
Family
ID=38344791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006536844A Withdrawn JP2007520452A (ja) | 2003-10-24 | 2004-10-25 | ホスホネート誘導体としてのイノシン一リン酸デヒドロゲナーゼインヒビター |
Country Status (7)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2523083C (en) | 2003-04-25 | 2014-07-08 | Gilead Sciences, Inc. | Antiviral phosphonate analogs |
| US7683188B2 (en) | 2004-04-26 | 2010-03-23 | TEVA Gyógyszergyár Zártkōrūen Mūkōdō Részvénytársaság | Process for preparation of mycophenolic acid and ester derivatives thereof |
| PT1778251E (pt) | 2004-07-27 | 2011-06-29 | Gilead Sciences Inc | Análogos de fosfonato de compostos inibidores de vih |
| JP2009502964A (ja) * | 2005-07-27 | 2009-01-29 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖを阻害するための抗ウイルス性ホスホン酸結合体 |
| DE102005057924A1 (de) * | 2005-12-05 | 2007-06-06 | Merck Patent Gmbh | Pyridazinonderivate |
| CA2729769C (en) | 2008-07-08 | 2017-09-05 | Gilead Sciences, Inc. | Salts of hiv inhibitor compounds |
| SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
| BRPI1009324A2 (pt) * | 2009-03-20 | 2015-11-24 | Alios Biopharma Inc | compostos e/ou farmaceuticamente aceitáveis dos mesmos, composição farmacêutica e respectivos usos |
| WO2010120388A1 (en) | 2009-04-17 | 2010-10-21 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
| US8530492B2 (en) * | 2009-04-17 | 2013-09-10 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
| AU2010270714B2 (en) | 2009-07-06 | 2015-08-13 | Wave Life Sciences Ltd. | Novel nucleic acid prodrugs and methods use thereof |
| BR112013005872A2 (pt) | 2010-09-22 | 2019-09-24 | Alios Biopharma Inc | compostos, composição farmacêutica e respectivos usos |
| US10428019B2 (en) | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
| DK2734208T3 (en) | 2011-07-19 | 2017-06-19 | Wave Life Sciences Ltd | PROCEDURES FOR SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS |
| AU2012358804B2 (en) | 2011-12-22 | 2018-04-19 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
| US8916538B2 (en) | 2012-03-21 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| EP2827876A4 (en) | 2012-03-22 | 2015-10-28 | Alios Biopharma Inc | PHARMACEUTICAL COMBINATIONS WITH A THIONUCLEOTIDE ANALOG |
| US9598458B2 (en) | 2012-07-13 | 2017-03-21 | Wave Life Sciences Japan, Inc. | Asymmetric auxiliary group |
| US10160969B2 (en) | 2014-01-16 | 2018-12-25 | Wave Life Sciences Ltd. | Chiral design |
| HRP20211456T1 (hr) | 2014-12-26 | 2021-12-24 | Emory University | Protuvirusni derivati n4-hidroksicitidina |
| CN106565769B (zh) * | 2016-11-12 | 2018-12-04 | 北京汇康博源医药科技有限公司 | 恩替卡韦中间体的合成工艺 |
| EP3960740B1 (en) | 2017-08-01 | 2023-11-15 | Gilead Sciences, Inc. | Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) vanillate for treating viral infections |
| KR102248165B1 (ko) | 2017-12-07 | 2021-05-06 | 에모리 유니버시티 | N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도 |
| CN110726801A (zh) * | 2019-10-31 | 2020-01-24 | 山东泰星新材料股份有限公司 | 一种监测烷基次膦酸反应状态的方法 |
| IT202100005777A1 (it) | 2021-03-11 | 2022-09-11 | Hippocrates Res S R L | Composizione per l’uso nel trattamento dell’occhio secco |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631370A (en) * | 1988-01-20 | 1997-05-20 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
| US5177064A (en) * | 1990-07-13 | 1993-01-05 | University Of Florida | Targeted drug delivery via phosphonate derivatives |
| US5610294A (en) * | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| US5654286A (en) * | 1993-05-12 | 1997-08-05 | Hostetler; Karl Y. | Nucleotides for topical treatment of psoriasis, and methods for using same |
| EP0708760A1 (en) * | 1993-07-14 | 1996-05-01 | Novartis AG | Cyclic hydrazine compounds |
| US5446137B1 (en) * | 1993-12-09 | 1998-10-06 | Behringwerke Ag | Oligonucleotides containing 4'-substituted nucleotides |
| US5493030A (en) * | 1994-02-18 | 1996-02-20 | Syntex (U.S.A.) Inc. | 5-substituted derivatives of mycophenolic acid |
| US5854227A (en) * | 1994-03-04 | 1998-12-29 | Hartmann; John F. | Therapeutic derivatives of diphosphonates |
| US5747498A (en) * | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US5750493A (en) * | 1995-08-30 | 1998-05-12 | Raymond F. Schinazi | Method to improve the biological and antiviral activity of protease inhibitors |
| US5914332A (en) * | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5874577A (en) * | 1996-04-03 | 1999-02-23 | Medichem Research, Inc. | Method for the preparing 9-12-(Diethoxyphosphonomethoxy)ethyl!adenine and analogues thereof |
| CA2261619C (en) * | 1996-07-26 | 2006-05-23 | Gilead Sciences, Inc. | Nucleotide analogs |
| US6312662B1 (en) * | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| US6174888B1 (en) * | 1998-05-28 | 2001-01-16 | Novartis Ag | 2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydropyrrolo[3,2-D]pyrimidin-4-ones |
| TNSN00027A1 (fr) * | 1999-02-12 | 2005-11-10 | Vertex Pharma | Inhibiteurs de l'aspartyle protease |
| US6258831B1 (en) * | 1999-03-31 | 2001-07-10 | The Procter & Gamble Company | Viral treatment |
| US6608027B1 (en) * | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
| JP4773010B2 (ja) * | 1999-06-25 | 2011-09-14 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｉｍｐｄｈのカーバメート阻害剤のプロドラッグ |
| WO2001064693A1 (fr) * | 2000-02-29 | 2001-09-07 | Mitsubishi Pharma Corporation | Compose de nucleotide de phosphonate |
| DK2682397T3 (da) * | 2000-07-21 | 2017-06-19 | Gilead Sciences Inc | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
| KR20020097384A (ko) * | 2001-06-20 | 2002-12-31 | 미쯔비시 도꾜 세이야꾸 가부시끼가이샤 | 기존의 약제에 내성변이를 가지는 바이러스에 유효한 약제 |
| KR100987815B1 (ko) * | 2002-04-26 | 2010-10-18 | 길리애드 사이언시즈, 인코포레이티드 | Ｈｉｖ 프로테아제 억제제 화합물의 포스포네이트유사체의 세포 축적 |
| WO2005011709A1 (en) * | 2003-02-19 | 2005-02-10 | Yale University | Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections |
-
2004
- 2004-04-26 CN CN2004800145255A patent/CN101410120A/zh active Pending
- 2004-10-25 EP EP04817344A patent/EP1680129A2/en not_active Withdrawn
- 2004-10-25 AU AU2004283710A patent/AU2004283710A1/en not_active Abandoned
- 2004-10-25 WO PCT/US2004/035136 patent/WO2005039552A2/en active Application Filing
- 2004-10-25 CA CA002542967A patent/CA2542967A1/en not_active Abandoned
- 2004-10-25 JP JP2006536844A patent/JP2007520452A/ja not_active Withdrawn
-
2006
- 2006-04-19 US US11/406,750 patent/US20070027116A1/en not_active Abandoned
