JP2007511570A - 不適切なａｌｋ５に関連する疾患を治療するための１−アミノ−イソキノリン誘導体 - Google Patents
不適切なａｌｋ５に関連する疾患を治療するための１−アミノ−イソキノリン誘導体 Download PDFInfo
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- JP2007511570A JP2007511570A JP2006540319A JP2006540319A JP2007511570A JP 2007511570 A JP2007511570 A JP 2007511570A JP 2006540319 A JP2006540319 A JP 2006540319A JP 2006540319 A JP2006540319 A JP 2006540319A JP 2007511570 A JP2007511570 A JP 2007511570A
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- JP
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- Prior art keywords
- hydroxyphenyl
- phenyl
- aminoisoquinoline
- amino
- isoquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 201000010099 disease Diseases 0.000 title claims description 33
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- -1 benzoimidazolyl group Chemical group 0.000 claims abstract description 60
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 32
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 30
- 239000012453 solvate Substances 0.000 claims abstract description 29
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 12
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- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims abstract description 10
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 8
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- 125000002950 monocyclic group Chemical group 0.000 claims abstract description 5
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Classifications
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- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0326963.6A GB0326963D0 (en) | 2003-11-19 | 2003-11-19 | Compounds |
| PCT/EP2004/013072 WO2005049577A1 (en) | 2003-11-19 | 2004-11-17 | 1-amino-isoquinoline derivatives for the treatment of diseases associated with inappropriate alk5 |
Publications (2)
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| JP2007511570A true JP2007511570A (ja) | 2007-05-10 |
| JP2007511570A5 JP2007511570A5 (https=) | 2007-12-06 |
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| EP (1) | EP1689718A1 (https=) |
| JP (1) | JP2007511570A (https=) |
| GB (1) | GB0326963D0 (https=) |
| WO (1) | WO2005049577A1 (https=) |
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| WO2007005668A2 (en) * | 2005-06-30 | 2007-01-11 | Amgen Inc. | Bis-aryl kinase inhibitors and their use in the treatment of inflammation, angiogenesis and cancer |
| EP1979348B1 (en) * | 2005-12-21 | 2012-01-18 | Abbott Laboratories | Anti-viral compounds |
| US7989461B2 (en) | 2005-12-23 | 2011-08-02 | Amgen Inc. | Substituted quinazolinamine compounds for the treatment of cancer |
| CA2874764C (en) | 2012-05-30 | 2022-11-01 | Cornell University | Generation of functional and durable endothelial cells from human amniotic fluid-derived cells |
| WO2014197421A1 (en) | 2013-06-05 | 2014-12-11 | Biotime, Inc. | Compositions and methods for induced tissue regeneration in mammalian species |
| US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
| US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
| WO2016014674A1 (en) * | 2014-07-22 | 2016-01-28 | University Of Maryland, College Park | Linked diaryl compounds with anticancer properties and methods of using the same |
| CA3202332A1 (en) | 2015-12-07 | 2017-06-15 | Agex Therapeutics, Inc. | Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells |
| CN114761405A (zh) * | 2019-11-29 | 2022-07-15 | 南京明德新药研发有限公司 | 抗hbv的1,7-萘啶类化合物 |
| US20250092031A1 (en) * | 2023-09-20 | 2025-03-20 | Momentum Therapeutics, Inc. | Ripk3 inhibitors and methods of use |
Citations (2)
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| WO2001087845A2 (en) * | 2000-05-15 | 2001-11-22 | Fujisawa Pharmaceutical Co., Ltd. | N-containing heterocyclic compounds and their use as 5-ht antagonists |
| JP2004517068A (ja) * | 2000-11-16 | 2004-06-10 | スミスクライン・ビーチャム・コーポレイション | 化合物 |
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| WO2004065392A1 (en) * | 2003-01-24 | 2004-08-05 | Smithkline Beecham Corporation | Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands |
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2004
- 2004-11-17 US US10/595,911 patent/US20070072901A1/en not_active Abandoned
- 2004-11-17 EP EP04797975A patent/EP1689718A1/en not_active Withdrawn
- 2004-11-17 WO PCT/EP2004/013072 patent/WO2005049577A1/en not_active Ceased
- 2004-11-17 JP JP2006540319A patent/JP2007511570A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001087845A2 (en) * | 2000-05-15 | 2001-11-22 | Fujisawa Pharmaceutical Co., Ltd. | N-containing heterocyclic compounds and their use as 5-ht antagonists |
| JP2004517068A (ja) * | 2000-11-16 | 2004-06-10 | スミスクライン・ビーチャム・コーポレイション | 化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20070072901A1 (en) | 2007-03-29 |
| EP1689718A1 (en) | 2006-08-16 |
| GB0326963D0 (en) | 2003-12-24 |
| WO2005049577A1 (en) | 2005-06-02 |
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