JP2007300927A5 - - Google Patents

Claims (16)

An antibody comprising a heavy chain variable region having CDR1, comprising the amino acid sequence set forth in SEQ ID NO: 134, and CDR2, comprising the amino acid sequence set forth in SEQ ID NO: 134, and CDR1, comprising the amino acid sequence set forth in SEQ ID NO: 132. An antibody comprising a light chain variable region having a CDR1 comprising the amino acid sequence set forth in SEQ ID NO: 169, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO: 169, and a CDR1 comprising the amino acid sequence set forth in SEQ ID NO: 168. Heavy chain variable regions having CDRs 1, 2 and 3 comprising the amino acid sequences set forth in SEQ ID NOs: 132, 133 and 134, respectively, and CDRs 1, 2 and 3 comprising the amino acid sequences set forth in SEQ ID NOs: 167, 168 and 169, respectively. An antibody comprising a light chain variable region having An antibody comprising a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO: 60 and a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO: 71 . The antibody according to any one of claims 1 to 3 , which is a human antibody. The antibody according to claim 4, which is a chimeric antibody. An antibody that binds to glypican 3 and has high CDC activity against cells expressing glypican 3. An antibody that binds to glypican 3 and has high ADCC activity against cells expressing glypican 3. Polynucleotides encoding the heavy chain variable region or light chain variable region of an antibody of any of claims 1-8. The polynucleotide of Claim 9 which has the base sequence of sequence number 55 or 65 . A vector comprising the polynucleotide according to claim 9 or 10. A cell into which the vector according to claim 11 has been introduced. A method for producing an antibody, comprising culturing the cell according to claim 12 and isolating and purifying the antibody. The cell growth inhibitor which uses the antibody in any one of Claims 1-8 as an active ingredient. The anticancer agent which uses the antibody in any one of Claims 1-8 as an active ingredient. The anticancer agent according to claim 15 for treating hepatocellular carcinoma.