JP2007292585A - Sample analysis system - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a sample analysis system, having a structure capable of simply collecting a sample from an analyzing target to properly preserving the same, and of properly analyzing the sample without causing the sample to deteriorate. <P>SOLUTION: The sample is collected from the analysis target by the sample adsorbing material of the leading end of the shaft member of the hermetically closing lid body, detached from the sample preserving container of a sample preserving device 100 and is preserved in the sample preserving device 100, and then the component of the sample is analyzed by a biosensor 250. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a sample analysis system that collects a sample from an analysis target and analyzes the components, and more particularly to a sample analysis system that uses a surface plasmon resonance type biosensor.

  The detection of explosives and narcotics mainly at airports, customs, and other places, and their detection methods depended on methods using dogs. However, this method depends on the physical condition of the dog and individual differences, and there is a problem that the detection / discovery ability tends to vary. In addition, there is a problem that a great expense is required for training a dog that can play an active role in the above-mentioned places.

  On the other hand, as a method for detecting a specific explosive / narcotic component, chemical component analyzing means by gas chromatography has been used. However, there are three major problems when detecting these components using this method.

  First, it is difficult to accurately inject samples into the equipment used in the method. This is because a technique and method for reliably sampling samples suspected of explosives and narcotics are not well established.

  As an example, there is a technique of sampling with a suction device simulating a vacuum cleaner, and as another example, there is a method of sampling with a wiping material made of paper or cloth. In these methods, it is difficult to quickly inject these components from the suction device or the wiping material into the device.

  Second, it is difficult to track the location and time of specific explosives and narcotics from the detection results obtained from a large number of samples. This is because the information on the sampled place / time and the detection result are not linked.

  Third, there is a problem related to the first and second, but it is difficult to stably store and store the sampled sample. Explosives and narcotics are highly reactive substances and have been neglected, although careful attention should be given to storage and storage.

  As a means of analyzing explosives and narcotics other than gas chromatography, the surface plasmon resonance (SPR) method using the antigen-antibody reaction of a surface plasmon resonance type biosensor is used. Can be analyzed continuously.

Currently, there are various proposals for detecting explosives and narcotics by the aforementioned SPR method (see, for example, Patent Documents 1 to 3).
JP 2006-471161 JP 09-126964 A JP 07-006729 A

  However, with the conventional method, it is difficult to easily collect a sample from an analysis target. Furthermore, the collected sample cannot be stored well. For this reason, the collected sample may be altered before analysis, and the analysis accuracy is lowered.

  Moreover, in the conventional method, it is necessary to obtain the analysis target with certainty. For this reason, for example, even a suspect suspected of possessing explosives or drugs cannot be inspected for the presence of explosives or drugs unless they are restrained.

  A first sample analysis system according to the present invention includes a sample storage container partially opened, a sealed lid that is detachably attached to the opening and seals the sample storage container, and an end on the inner surface of the sealed lid A long and thin shaft member that is integrally connected and the tip is located inside the sample storage container, a sample adsorbent that is located at the tip of the shaft member and adsorbs the sample from the analysis target, and a surface plasmon resonance type that analyzes the component of the sample And a biosensor.

  Therefore, in the sample analysis system of the present invention, a sample is collected from the analysis target with the sample adsorbent at the tip of the shaft member of the sealed lid removed from the sample storage container, and the sample is stored inside the sample storage container. The components are analyzed by biosensor.

  A second sample analysis system according to the present invention includes a surface plasmon resonance type biosensor that analyzes a component of a sample, a sample storage container that contains a buffer solution, and sucks air from the periphery of the analysis target to draw the sample into the buffer solution. An air suction mechanism for injecting, and a solution transfer unit for transferring the buffer solution from the sample storage container to the biosensor.

  Therefore, in the sample analysis system of the present invention, the sample is injected into the buffer solution by sucking air from around the analysis target, and the sample of the buffer solution is subjected to component analysis by the biosensor, thereby contacting the analysis target. It is possible to analyze the components of the sample without any problem.

  It should be noted that the various components referred to in the present invention do not necessarily have to be independent of each other, a plurality of components are formed as a single member, and a single component is formed of a plurality of members. It is also possible that a certain component is a part of another component, a part of a certain component overlaps a part of another component, and the like.

  In the first sample analysis system of the present invention, a sample can be sampled from the analysis target with the sample adsorbent at the tip of the shaft member of the hermetic lid removed from the sample storage container, and the sample is stored inside the sample storage container. Since the component can be analyzed with the biosensor after being stored in step 1, a sample can be easily collected from the analysis target and stored well, and the component can be analyzed well without altering the sample.

  In the second sample analysis system of the present invention, the sample is injected into the buffer solution by sucking air from around the analysis target, and the sample of the buffer solution is analyzed by the biosensor to contact the analysis target. Since the sample can be analyzed without any analysis, even gas components such as odors can be analyzed by the SPR method. For example, the presence or absence of explosives or narcotics can be inspected without the suspect being noticed. .

  A first embodiment of the present invention will be described below with reference to the drawings. The sample analysis system 10 of the present embodiment is used for collecting a sample from an analysis target and analyzing the components. For this reason, the sample analysis system 10 of the present embodiment includes a collection and storage device 100, a solution injector 140, a sample analysis device 200, and a data processing device 270, as shown in FIG.

  As shown in FIG. 2, the collection and storage device 100 includes a sample storage container 110, a sealing lid 111, a shaft member 112, a sample adsorbent 113, a desiccant 120, a deoxygenating agent 121, and an RFID tag 130 as a data medium. Have.

  The sample analyzer 200 includes an analyzer main body 210, a turntable 220 as a container transport mechanism, a dispenser 230 as a solution transfer unit, an RFID reader 240 as a data reader, a surface plasmon resonance type biosensor 250, and the like. Have

  More specifically, each part of the sample storage container 110 is formed of a material that does not react with the sample and the buffer solution B of the biosensor 250. The sample storage container 110 is formed of a light shielding resin or the like in a cylindrical shape with a part opened.

  The sealing lid 111 seals the sample storage container 110 by being detachably attached to the opening of the sample storage container 110. The shaft member 112 has a distal end integrally connected to the inner surface of the hermetic lid 111, and is formed in an elongated shape whose tip is located inside the sample storage container 110.

  The sample adsorbing material 113 is located at the tip of the shaft member 112 and adsorbs the sample from the analysis target. However, since the sample adsorbent 113 does not react with the sample as described above, the sample adsorbent 113 is formed in a material and a structure that adsorbs the sample due to physical properties such as electrostatic action and adhesiveness. Further, the sample adsorbent 113 is formed in a material and structure that do not generate contamination even when the buffer solution B is injected into the sample storage container 110.

  The desiccant 120 is made of, for example, silica gel enclosed in a non-woven bag, and is contained in the sample storage container 110 to dry the atmosphere without reacting with the sample. The oxygen scavenger 121 is made of, for example, iron powder enclosed in a non-woven bag, and is stored in the sample storage container 110 to absorb oxygen from the atmosphere without reacting with the sample.

  For example, the RFID tag 130 is attached to the outer peripheral surface of the sample storage container 110, and ID data unique to the collection storage device 100 is registered. For example, the RFID tag 130 wirelessly transmits registration data only for an extremely short distance of about several centimeters.

  The solution injector 140 is formed in a cylindrical shape with a light-shielding resin that does not react with the buffer solution B for the biosensor 250. As shown in FIG. 1, the solution injector 140 is a container used for storing the buffer solution B and injecting it into the sample storage container 110.

  The analyzer main body 210 of the sample analyzer 200 is formed in a box shape. A turntable 220 is rotatably mounted on one end of the upper surface of the analyzer main body 210. A dispenser 230 and an RFID reader 240 are juxtaposed at a position facing the turntable 220 on the upper surface of the analyzer main body 210.

  In the turntable 220, a concave groove in which a plurality of sample storage containers 110 are arranged is formed on the outer peripheral portion of the upper surface. For this reason, the turntable 220 holds a plurality of sample storage containers 110 and sequentially conveys them to the positions of the dispenser 230 and the RFID reader 240.

  The dispenser 230 transfers the buffer solution B from the sample storage container 110 conveyed in turn by the turntable 220 to the biosensor 250. More specifically, as shown in FIG. 3, an opening hole 211 is formed near the center of the upper surface of the analyzer main body 210. The biosensor 250 is disposed inside the opening hole 211.

  The dispenser 230 is formed in a reverse J shape, and is pivotally supported. Therefore, as will be described in detail later, as shown in FIG. 9, the tip of the tip moves to a position facing the turntable 220 and the opening hole 211 from above.

  Further, the tip of the dispenser 230 is formed to be extendable in the vertical direction. Therefore, as shown in FIGS. 9A and 9B, the dispenser 230 sucks and holds the buffer solution B from the sample storage container 110 that is sequentially conveyed by the turntable 220, and holds the held buffer solution. B is supplied to the biosensor 250 by discharging it into the opening hole 211.

  The RFID reader 240 reads ID data and the like from the RFID tag 130 of the sample storage container 110 that is sequentially conveyed by the turntable 220. Since the RFID reader 240 has a very short communication distance, the RFID reader 240 wirelessly communicates only with the RFID tag 130 of the sample storage container 110 to which the buffer solution B is transferred by the dispenser 230.

  As shown in FIGS. 4 and 5, the biosensor 250 includes an optical prism 251, a plurality of metal films 252, and an optical unit (not shown). The optical prism 251 is formed in an elongated triangular prism shape.

  The plurality of metal films 252 are made of gold or the like and arranged on one surface of the optical prism 251. The optical unit irradiates the plurality of metal films 252 of the optical prism 251 with laser beams individually and detects the laser beams reflected by the plurality of metal films 252 individually.

  Inside the analyzer main body 210, an optical unit of the biosensor 250 and a sensor holding mechanism (not shown) are fixed at predetermined positions. As shown in FIG. 4, this sensor holding mechanism holds the optical prism 251 at a position facing the optical unit in a replaceable manner.

  In addition, a flow path is formed by a flow path member 212 from the opening hole 211 to the position of the biosensor 250 inside the analyzer main body 210. Therefore, the buffer solution B injected from the dispenser 230 into the opening hole 211 as described above is uniformly supplied onto the plurality of metal films 252 of the biosensor 250.

  Further, the analyzer main body 210 also includes a solution supply mechanism 260. The solution supply mechanism 260 supplies the biosensor 250 with a buffer solution containing an antibody, a buffer solution not containing an antibody, and a washing solution in a switchable manner.

  More specifically, as shown in FIG. 6, the solution supply mechanism 260 includes the same number of antibody supply tanks 261, one buffer solution supply tank 262, one washing solution tank 263, and one waste solution as the metal films 252 of the biosensor 250. The tank 264 includes a plurality of pipes 265 individually attached to the tanks 261 to 264, pump devices (not shown) individually connected to the plurality of pipes 265, and the like.

  A plurality of types of buffer solutions containing different antibodies are individually stored in the plurality of antibody supply tanks 261. Therefore, a plurality of types of buffer solutions containing different antibodies are individually supplied onto the plurality of metal films 252 from the plurality of antibody supply tanks 261 to the biosensor 250.

  From the buffer solution supply tank 262 to the biosensor 250, a buffer solution containing no antibody is uniformly supplied onto the plurality of metal films 252. The cleaning liquid is uniformly supplied from the cleaning liquid tank 263 to the biosensor 250 on the plurality of metal films 252. In the waste liquid tank 264, the buffer solution and the cleaning liquid supplied to the biosensor 250 are collected as waste liquid.

  When the sample and the antibody are supplied by the buffer solution B and the buffer solution as described above, the biosensor 250 measures the plasmon resonance angle of the antigen-antibody reaction generated on the surface of the metal film 252 by the optical unit. .

  The replacement optical prism 251 is stored in a dedicated sensor storage device 280 as shown in FIG. The sensor storage device 280 includes a conductive sheet 281, a sensor sealed container 282, a desiccant 283, and an oxygen scavenger 284.

  The conductive sheet 281 wraps the replacement optical prism 251. The sensor sealed container 282 seals the optical prism 251 packaged with the conductive sheet 281. The desiccant 283 and the oxygen scavenger 284 are accommodated inside the sensor sealed container 282.

  The data processing device 270 is a so-called personal computer. As shown in FIG. 1, the RFID reader 240 and the biosensor 250 of the sample analyzer 200 are connected to the data processing device 270.

  In the data processing device 270, a component database is constructed, and the analysis target component to be detected is registered in the data database. Further, the data processing device 270 is implemented with a computer program for collating the detection result of the biosensor 250 with the registered data in the database and specifying the analysis target to be detected.

  Further, an ID database is also built in the data processing device 270, and the detection result of the RFID reader 240 is registered in the data database. Further, the data processing device 270 is also implemented with a computer program that associates the detection result of the RFID reader 240 with the detection result of the biosensor 250.

  In the configuration as described above, a method of using the sample analysis system 10 of the present embodiment will be specifically described below. The sample analysis system 10 of the present embodiment is installed, for example, in an airport luggage inspection unit (not shown), and is used for identifying illegal substances such as narcotics and explosives.

  In this case, as shown in FIG. 8, for example, RFID tags 290 in which unique ID data are registered are individually attached to the package L to be analyzed. Such an RFID tag 290 can also be used as an identification tag when an airline deposits a package L from a customer (not shown).

  A worker (not shown) carries a handy type RFID reader (not shown) and a plurality of collection and storage devices 100 and individually collects samples from the luggage L. In that case, the worker reads the ID data from the RFID tag 290 of the luggage L with the RFID reader. Next, the worker selects a new one from the plurality of collection and storage devices 100 and reads the RFID tag 130 with an RFID reader.

  Thus, the RFID reader associates the ID data of the package L and the collection / storage device 100, and for example, the associated pair of ID data is transmitted to the data processing device 270 by wired or wireless communication. The data processing device 270 registers the received ID data in the ID database.

  On the other hand, as shown in FIG. 2, the worker removes the sealing lid 111 from the sample storage container 110 of the collection storage device 100 that has read the RFID tag 130. Next, while holding the sealing lid 111 with fingers (not shown), a sample is collected from the surface of the luggage L with the sample adsorbent 113 as shown in FIG.

  When the collection is completed, the sealing lid 111 is mounted on the sample storage container 110 while being held with fingers. Thus, the sample adsorbent 113 that has adsorbed the sample is disposed in a non-contact manner inside the sample storage container 110.

  As described above, when samples are individually collected from the plurality of loads L by the plurality of collection and storage devices 100, the plurality of collection and storage devices 100 are collected at the position of one sample analyzer 200.

  Therefore, as shown in FIG. 1, the desiccant 120 and the oxygen scavenger 121 are taken out from the sample storage container 110 from which the hermetic lid 111 has been removed. The buffer solution B is injected from the solution injector 140 into the sample storage container 110 in such a state.

  Next, the sample adsorbent 113 is immersed in the buffer solution B of the sample storage container 110, so that the collected sample is trapped in the buffer solution B. In addition, the trap mentioned here should just exist in the buffer solution B in the state which can analyze a sample, and specifically, any of melt | dissolution, dispersion | distribution, and these combination may be sufficient.

  A plurality of sample storage containers 110 each processed as described above are arranged on the turntable 220 of the sample analyzer 200 as shown in FIG. When the turntable 220 rotates in such a state, the plurality of sample storage containers 110 are sequentially conveyed to the positions of the dispenser 230 and the RFID reader 240 as shown in FIG.

  Then, the RFID reader 240 reads ID data from the RFID tag 130 of the transported sample storage container 110. The dispenser 230 transfers the buffer solution B from the sample storage container 110 from which the RFID tag 130 has been read to the biosensor 250 in the opening hole 211.

  The biosensor 250 analyzes components of the supplied buffer solution B. More specifically, since the cleaning liquid is uniformly supplied to the plurality of metal films 252 of the biosensor 250 before the buffer solution B is supplied, the metal film 252 is cleaned by this.

  Next, since a buffer solution containing no antibody is uniformly supplied to the plurality of metal films 252 of the biosensor 250, the antibody is easily fixed to the metal film 252 and processed. Since a plurality of types of buffer solutions containing different antibodies in such a state are individually supplied to the plurality of metal films 252 of the biosensor 250, a plurality of antibodies are individually applied to the surfaces of the plurality of metal films 252. Fixed to.

  In such a state, since the buffer solution B is uniformly supplied to the plurality of metal films 252 of the biosensor 250, the sample trapped in the buffer solution B is subjected to component analysis by a plurality of types of antibodies.

  The analysis result is transferred from the biosensor 250 to the data processing device 270. Since the ID data is also transferred from the RFID reader 240 to the data processing device 270, the ID data and the analysis result of the sample are also associated and registered.

  Then, the data processing device 270 determines whether the sample is not a drug or an explosive by comparing the component analyzed from the sample with the registered data in the component database. If it is determined that this is a narcotic or an explosive, for example, the data processing device 270 issues a warning by voice and display to the operator.

  At the same time, the data processing device 270 searches the ID data of the luggage L from the ID data of the sample storage container 110 transferred together with the component result of the sample, and presents the ID data to the operator.

  The sample analysis system 10 of the present embodiment has the following effects by functioning as described above. First, as shown in FIGS. 2 and 8, the sample can be collected from the luggage L by the sample adsorbent 113 at the tip of the shaft member 112 of the sealing lid 111 removed from the sample storage container 110.

  Furthermore, the component can be analyzed by the biosensor 250 after the sample is stored in the sample storage container 110. For this reason, a sample can be easily collected from the luggage L and stored well, and component analysis can be performed well without altering the sample.

  In particular, as shown in FIG. 2, the sample storage container 110 contains a desiccant 120 and an oxygen scavenger 121. Moreover, the sample storage container 110 is formed with a light shielding property. For this reason, the unused sample adsorbent 113 can be stored for a long time in a good quality state. Furthermore, since the sample collected by the sample adsorbent 113 can also be prevented from being altered, the analysis accuracy of the sample analyzer 200 can be improved.

  Further, as shown in FIG. 1, the buffer solution B is injected into the sample storage container 110 by the solution injector 140, and the buffer solution B is transferred from the sample storage container 110 to the biosensor 250. Therefore, the sample collected and stored in the sample storage container 110 can be easily supplied to the biosensor 250.

  In addition, as shown in FIG. 3, a plurality of sample storage containers 110 are held by the turntable 220 of the sample analyzer 200 and are sequentially conveyed to the position of the dispenser 230. For this reason, samples collected from a plurality of packages L can be quickly analyzed.

  Further, as shown in FIGS. 2 and 8, RFID tags 130 and 290 are attached to the collection and storage device 100 and the package L, and the ID data is managed by the data processing device 270 together with the analysis result of the sample. For this reason, when the sample is determined to be a narcotic or an explosive, the luggage L in which the narcotic or explosive is detected can be easily and reliably specified.

  In particular, as shown in FIG. 3, in the sample analyzer 200, an RFID reader 240 is provided in parallel with a dispenser 230. Therefore, the ID data is automatically read from the RFID tag 130 of the sample storage container 110 from which the buffer solution B is collected by the dispenser 230, and the ID data and the analysis result of the sample are accurately related.

  Moreover, the RFID tag 130 and the RFID reader 240 have a very short communication distance. For this reason, ID data can be read only from the RFID tag 130 of the sample storage container 110 from which the buffer solution B is collected by the dispenser 230.

  In the biosensor 250, as shown in FIG. 5, a plurality of metal films 252 are formed on the optical prism 251, and a plurality of types of buffer solutions with different antibodies are individually supplied to the plurality of metal films 252. The Therefore, a single biosensor 250 can simultaneously analyze a plurality of components, and a sample can be inspected at a speed several times that of the conventional method.

  In addition, a buffer solution containing an antibody, a buffer solution not containing an antibody, and a washing solution are appropriately supplied to the biosensor 250. Therefore, a single biosensor 250 can analyze a plurality of samples with good accuracy.

  Furthermore, in the sample analyzer 200, as shown in FIG. 6, a plurality of antibody supply tanks 261, one buffer solution supply tank 262, one washing solution tank 263, and one waste solution tank 264 having different antibodies are integrally formed. Has been.

  For this reason, compared with the case where the above-mentioned tanks 261-264 are mounted individually, the occupied volume is reduced significantly. In addition, the plurality of tanks 261 to 264 can be replaced at a time, and a plurality of types of solutions can be filled with this one replacement, and the waste liquid can be discarded.

  Moreover, as shown in FIG. 4, the sample analyzer 200 is mounted with the optical prism 251 of the biosensor 250 in a replaceable manner. Therefore, it is possible to easily replace the optical prism 251 whose accuracy has been lowered by analyzing a plurality of samples, and the analysis accuracy of the sample analyzer 200 can be favorably maintained.

  In addition, as shown in FIG. 7, the replacement optical prism 251 is stored in a dedicated sensor storage device 280. Therefore, the replacement optical prism 251 can be stored in a good state for a long time.

  In addition, since the metal film 252 of the optical prism 251 as described above is manufactured in a clean room by a thin film technique, it is preferably sealed in the sensor storage device 280 immediately after the manufacturing. Here, a method of manufacturing the metal film 252 on the optical prism 251 will be briefly described below with reference to FIG.

  First, as shown in FIG. 10A, an optical prism 251 is prepared, and as shown in FIG. 10B, a photoresist 255 is applied on one surface thereof. Next, as shown in FIG. 10C, the photoresist 255 is patterned.

  Next, as shown in FIG. 10D, a metal film 252 is formed on one surface of the optical prism 251 by vapor deposition or sputtering using the patterned photoresist 255 as a mask.

  Then, as shown in FIG. 10E, by removing the photoresist 255, an optical prism 251 having a plurality of metal films 252 formed on one surface is completed. In the manufacturing method described above, a plurality of metal films 252 can be formed on one optical prism 251 with good smoothness, and the performance of the biosensor 250 can be improved.

  In the present invention, an experiment was conducted in which a plurality of metal films 252 were actually manufactured on one optical prism 251 by the method described above, and the optical prism 251 was stored in the sensor storage device 280 for one month.

  When the optical prism 251 taken out from the sensor storage device 280 was loaded into the sample analyzer 200, the same performance as that of a new product was immediately demonstrated. On the other hand, when the optical prism 251 that was left for one month without using the sensor storage device 280 was loaded into the sample analyzer 200, measurement was impossible.

  In this case, the optical prism 251 can be used by washing with 0.1 M hydrochloric acid, but the washing took 30 minutes. That is, it was confirmed that the optical prism 251 can be stored in a good state for a long period of time by the sensor storage device 280 described above.

  The present invention is not limited to the present embodiment, and various modifications are allowed without departing from the scope of the present invention. For example, in the above embodiment, it is exemplified that the operator manually collects the sample from the luggage L by the collection and storage device 100, but this may be mechanized (not shown).

  In this case, for example, a robot arm or the like can be used to carry out a plurality of collections L with a plurality of collection and storage devices 100 by carrying a plurality of pieces of luggage L with a belt conveyor and collecting them with a plurality of collection and storage devices 100. (Not shown).

  Further, in the above embodiment, it is exemplified that the operator manually injects the buffer solution B from the solution injector 140 into the sample storage container 110. However, this may be automated. For example, the sample analyzer may inject the buffer solution B from the dispensing tube into the sample storage container 110.

Of course, by automating the entire sample analysis system 10 as described above, for example, the luggage L transported from the airport to the airplane can be automatically and quickly analyzed. Furthermore, it is possible to automatically analyze processed foods in food factories.


Further, in the above embodiment, the RFID tag 130 is mounted on the sample storage container 110 and the like, and the RFID reader 240 is mounted on the sample analyzer 200. However, the RFID tag 130 described above is replaced with a data medium such as a barcode, a two-dimensional code, and a magnetic stripe, and the RFID reader 240 is replaced with a data reader such as a barcode reader, a two-dimensional code reader, and a magnetic stripe reader. (Not shown).

  In the above embodiment, the RFID tag 290 that also serves as an identification tag is given to the package L. However, such an RFID tag 290 may be added to a package or a person in another form.

  For example, at present, it is considered to attach an RFID tag to a so-called passport (passport) (not shown). Therefore, if the ID data of the RFID tag is read with an RFID reader and associated with the ID data of the RFID tag 130 of the collection and storage device 100, the identities of the narcotics and explosives can be identified internationally. In particular, the identification tag of the package L can be easily discarded, but since it is difficult to discard the passport, the suspect can be identified more reliably.

  Further, ID data such as RFID tags 130 and 290 of the sample analyzer 200, the baggage L, and the passport are collected and linked to identify the baggage L in which narcotics or explosives are stored. You can also identify the identity of the owner.

  Further, an RFID tag may be attached to a ticket at a reserved seat in a movie theater, and the RFID tag may be read by an RFID reader and associated with the RFID tag 130 of the collection and storage device 100.

  In that case, for example, drugs or explosives can be reliably tested for all customers at a reserved seat in a movie theater. In addition, since an individual can be identified without requiring personal information, privacy infringement does not become a problem.

  Moreover, in the said form, it illustrated that the optical unit irradiates and detects simultaneously the laser beam to the some metal film 252 of the biosensor 250 individually. However, the optical unit may be detected by sliding the pair of laser light sources and photosensors, and sequentially irradiating the plurality of metal films 252 with laser light (not shown).

  Furthermore, in the above-described embodiment, the buffer solution B is uniformly supplied to the plurality of metal films 252 of the biosensor 250 after the plurality of types of buffer solutions containing different antibodies are individually supplied. Illustrated is that multiple components of the sample trapped in Solution B are analyzed at once.

  However, only one metal film may be formed on one optical prism of the biosensor, and a plurality of types of antibodies may be sequentially supplied thereto. In this case, since the sample must be supplied and washed each time the antibody type is switched, the throughput decreases. However, the structure of the biosensor may be simple.

  Furthermore, after a buffer solution containing one type of antibody is uniformly supplied to the plurality of metal films 252 of the biosensor 250, a plurality of types of buffer solutions B with different samples may be supplied individually. (Not shown).

  In this case, although one component can be analyzed, a plurality of types of samples can be analyzed at one time. Therefore, for example, one component such as a specific narcotic or explosive can be inspected with high efficiency.

  Of course, for example, four types of samples and two types of antibodies may be supplied in combination to the eight metal films 252 of one optical prism 251 of the biosensor 250 (not shown).

  Moreover, in the said form, the operator carried the collection preservation | save apparatus 100 which extract | collects a sample by contact, and illustrated that a sample was extract | collected by an operator's manual work. However, the collection and storage device may be formed in a structure for collecting the sample by sucking air around the analysis target.

  More specifically, as shown in FIG. 11, the collection and storage device 300 illustrated here includes a storage device body 301, a sample storage container 302, an intake pipe 303, an air suction mechanism 304, an exhaust pipe 305, and the like.

  The storage device main body 301 is formed in a box shape. The sample storage container 302 is disposed inside the storage device main body 301. The sample storage container 302 contains the buffer solution B.

  The intake pipe 303 is disposed on the upper surface of the storage device main body 301. The intake pipe 303 is formed in, for example, a funnel shape with an opening at the tip being expanded. The air suction mechanism 304 is a so-called pump. The air suction mechanism 304 sucks air A from the periphery of the analysis target through the intake pipe 303 and injects the air A into the buffer solution B of the sample storage container 302 through the exhaust pipe 305.

  Since the sample is trapped in the buffer solution B of the sample storage container 302, the sample is analyzed by, for example, loading the sample storage container 302 into the sample analyzer 200 described above.

  In the sample analysis system (not shown) using the above-described collection and storage device 300, the sample can be subjected to component analysis without contacting the analysis target. For this reason, even gas components such as odors can be analyzed by the SPR method. For example, the presence or absence of explosives or narcotics can be inspected without the suspect being noticed.

  Further, the collection and storage device 300 as described above may be linked with, for example, a face matching system (not shown). Such a face collation system accumulates criminal face photographs in a database and detects suspects from pedestrians by pattern matching.

  Thus, by operating the collection and storage device 300 when the face matching system detects a suspect, for example, a drug addict or a criminal of continuous explosion can be identified with good accuracy.

  Furthermore, it is not impossible for the collection and storage device 300 to detect substances generated when a human behaves abnormally. In this case, it is possible to quickly detect that a human behaves abnormally and prevent a crime.

  Further, the collection and storage device 300 as described above may be installed in a food factory (not shown). In this case, the component analysis can be performed using a odor emitted from the processed food as a sample. For this reason, for example, processing defects of food can be determined in a sanitary manner without contact.

  Further, the collection and storage device 300 as described above can be formed integrally with the sample analyzer (not shown). In that case, a mechanism for automatically supplying the buffer solution B from the collection and storage device 300 to the biosensor of the sample analyzer is formed.

  The sample analyzer 310 having such a structure can be mass-produced and arranged in a space S such as an airport as shown in FIG. In this case, a plurality of sample analyzers 310 are connected to one data processing device 270.

  In such a sample analysis system, for example, a plurality of sample analysis devices 310 periodically collect and analyze ambient air, and the data processing device 270 collects the analysis results. In this way, explosives and narcotics can be automatically detected, and the position and moving direction can be estimated.

  Note that an airflow measurement sensor (not shown) may be arranged in the space S as described above, and this may be connected to the data processing device 270. In this case, the data processing device 270 can determine the position and moving direction of explosives and narcotics in consideration of the measurement result of airflow.

  Further, the data processing device 270 may actively control the air flow by controlling the air conditioner system in the space S. Further, the direction in which the sample analyzer 310 sucks air may be automatically changed, and this may be controlled by the data processor 270 in accordance with the analysis result of the sample.

  In FIG. 12, the sample analyzers 310 are arranged at equal intervals, but may be arranged at unreasonable intervals. For example, by arranging the sample analyzer 310 in consideration of the airflow, good results can be obtained with the minimum necessary sample analyzer 310.

  Furthermore, although the planar arrangement of the sample analyzer 310 is illustrated in FIG. 12, it is needless to say that a plurality of sample analyzers 310 may be dispersed in the vertical direction and arranged in a three-dimensional manner. Alternatively, the sample analysis device 310 may be mounted on a mobile device such as an electric cart or an automatic cleaning robot (not shown), and the analysis result may be transmitted to the data processing device 270 wirelessly.

It is a schematic diagram which shows the structure of the sample analysis system of the 1st form of implementation of this invention. It is a typical front view which shows the collection preservation | save apparatus of a sample analysis system. It is a typical top view which shows the sample analyzer of a sample analysis system. It is a schematic diagram which shows the internal structure of the principal part of a sample analyzer. The optical prism of a biosensor is shown, (a) is a front view, (b) is a plan view. It is a schematic diagram which shows the tank unit of a solution supply mechanism. It is a schematic diagram which shows the state in which the optical prism was accommodated in the sensor preservation | save apparatus. It is a schematic diagram which shows the state which extract | collects a sample from the package which is an analysis object. It is a typical top view which shows operation | movement of a sample analyzer. It is process drawing which shows the method of forming a metal film in an optical prism. It is a typical vertical side view which shows the collection preservation | save apparatus of one modification. It is a schematic diagram which shows the sample analysis system of another modification.

Explanation of symbols

DESCRIPTION OF SYMBOLS 100 Sampling storage apparatus 110 Sample storage container 111 Sealing lid body 112 Shaft member 113 Sample adsorbent 120 Desiccant 121 Oxygen absorber 130 RFID tag 140 Solution injector 200 Sample analyzer 210 Analyzer main body 211 Opening hole 212 Channel member 220 Turn Table 230 Dispenser 240 RFID reader 250 Biosensor 251 Optical prism 252 Metal film 255 Photoresist 260 Solution supply mechanism 261 Antibody supply tank 262 Buffer solution supply tank 263 Cleaning solution tank 264 Waste solution tank 265 Piping 270 Data processing device 280 Sensor storage device 281 Conductive sheet 282 Sensor sealed container 283 Desiccant 284 Deoxygenating agent 290 RFID tag 300 Sampling and storage device 301 Storage device body 302 Sample storage container 303 Intake pipe 04 air suction mechanism 305 exhaust pipe 310 sample analyzer A air B buffer solution L luggage S Space

Claims (12)

A sample storage container partially open;
A sealing lid that is detachably attached to the opening and seals the sample storage container;
An elongate shaft member whose end is integrally connected to the inner surface of the hermetic lid and whose tip is located inside the sample storage container;
A sample adsorbent that adsorbs a sample from an analysis object located at the tip of the shaft member;
A surface plasmon resonance type biosensor for component analysis of the sample;
A sample analysis system. A desiccant contained in the sample storage container to dry the atmosphere without reacting with the sample;
An oxygen scavenger that is contained in the sample storage container and absorbs oxygen from the atmosphere without reacting with the sample;
The sample analysis system according to claim 1, further comprising: A solution injector for injecting a buffer solution into the sample storage container;
The sample analysis system according to claim 1, further comprising a solution transfer unit that transfers the buffer solution from the sample storage container to the biosensor. A surface plasmon resonance type biosensor for analyzing the components of the sample;
A sample storage container containing a buffer solution;
An air suction mechanism for sucking air from around the analysis target and injecting the sample into the buffer solution;
A solution transfer unit for transferring the buffer solution from the sample storage container to the biosensor;
A sample analysis system. A data medium attached to the sample storage container;
A data reader arranged in parallel in the solution transfer section,
The sample analysis system according to claim 3 or 4, further comprising:   The sample analysis system according to claim 5, wherein the data medium is an RFID (Radio Frequency Identification) tag, and the data reader is an RFID reader.   The sample analysis system according to any one of claims 3 to 6, further comprising a container transport mechanism that holds the plurality of sample storage containers and sequentially transports the sample storage containers to the position of the solution transport unit.   The sample according to any one of claims 4 to 7, further comprising a solution supply mechanism that switchesably supplies a buffer solution containing an antibody to the biosensor, a buffer solution not containing the antibody, and a washing solution. Analysis system. The biosensor includes an elongated triangular prism-shaped optical prism, a plurality of metal films arranged on one surface of the optical prism, and a plasmon resonance angle when the sample generates an antigen-antibody reaction on the surface of the metal film. An optical unit for measuring,
The solution transfer unit uniformly supplies the buffer solution onto the plurality of metal films of the biosensor,
The sample analysis system according to claim 8, wherein the solution supply mechanism individually supplies a plurality of types of the buffer solutions containing the different antibodies onto the plurality of metal films of the biosensor. The biosensor includes an elongated triangular prism-shaped optical prism, a plurality of metal films arranged on one surface of the optical prism, and a plasmon resonance angle when the sample generates an antigen-antibody reaction on the surface of the metal film. An optical unit for measuring,
The solution supply mechanism uniformly supplies the buffer containing the antibody onto the plurality of metal films of the biosensor,
The sample analysis system according to claim 8, wherein the solution transfer unit individually supplies a plurality of types of the buffer solutions having different samples onto the plurality of metal films of the biosensor.   The sample analysis system according to claim 9 or 10, further comprising a sensor mounting mechanism on which the optical prism of the biosensor is mounted in a replaceable manner. A conductive sheet for wrapping the optical prism not mounted on the sensor mounting mechanism;
A sensor sealed container that seals the optical prism packaged with the conductive sheet;
A desiccant contained in the sensor sealed container and drying the atmosphere;
An oxygen scavenger that is housed in the sensor sealed container and absorbs oxygen from the atmosphere;
The sample analysis system according to claim 11, further comprising:

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