JP2007277181A - Emulsion composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an emulsion composition which contains an oily raw material in a large amount, and has high transparency and excellent stability at high temperature. <P>SOLUTION: This emulsion composition is obtained by emulsifying a composition comprising an oily component, lecithin and a specific surfactant by a high pressure emulsifying method, has high transparency, and is excellent in stability at high temperature. When the emulsion composition is used as a milky lotion for makeup, the emulsion composition gives a light sense of use, in spite of containing the oily component in a large amount. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an emulsified composition. More specifically, the present invention relates to an emulsified composition excellent in transparency and stability.

  The emulsified composition is a uniform mixture of components that do not dissolve each other, such as an oily component and an aqueous component. By providing the oily component and the aqueous component as an emulsified composition, it is possible to provide one emulsified composition having the functionality and feel of both the oily component and the aqueous component. Because of such advantages, emulsion compositions are frequently used as cosmetic creams and emulsions, for example. The oil component in the emulsified composition of a skin external preparation such as cosmetics has an emollient effect that protects the skin and moisturizes the skin, as well as the action of dissolving the oil-soluble active ingredient. Therefore, if the content of the oil component in the emulsified composition is increased, the emollient effect is enhanced.

  However, in the conventional emulsified composition, if the content of the oil component in the emulsified composition is increased, the transparency is lost and the color tone is changed to white, and the tactile sensation and stickiness are also increased. Moreover, if the content of the oil component of a normal emulsified composition is increased, the stability at high temperature is also impaired, and at a temperature of 80 ° C. or higher, the emulsification is broken and the oil component and the aqueous component are separated.

  From these problems, although there is a transparent emulsion composition having an oily component of less than 3% by weight (for example, Patent Document 1), it still contains 3% by weight or more of an oily component and has high transparency and stickiness. An emulsified composition that has a low tactile sensation and is stable even when heated for a long time under high temperature conditions of 80 ° C. or higher has not been developed.

Prior art document information relating to the invention of this application includes the following.
Japanese Patent Laid-Open No. 2005-220029

  From such a situation, it is a problem to be solved by the present invention to develop an emulsified composition having a high transparency and a refreshing feeling even though the content of the oil component is high.

  The inventors of the present invention emulsify a specific novel prescription mixture by a high-pressure emulsification method, so that despite having a high content of oily components, it has a high transparency and a refreshing feeling of use at high temperatures. The present invention was completed by developing a stable emulsion composition.

Accordingly, the present invention provides the following.
(Item 1)
It is emulsified by a high-pressure emulsification method containing 3 to 30% by weight of an oily component, 0.1 to 10% by weight of lecithin, and 0.1 to 10% by weight of a surfactant having an HLB value of 13 to 17. Emulsified composition.
(Item 2)
3 to 30% by weight of an oil component, 0.1 to 10% by weight of lecithin, and 0.1 to 10% by weight of a surfactant having an HLB value of 13 to 17 and having a transparency of 0.3 That's it, milk (item 3)
Item 3. The emulsion composition according to Item 2, wherein the transparency is 0.8 or more.
(Item 4)
The emulsified composition according to any one of Items 1 to 3, wherein a weight ratio of the oil component, the lecithin, and the surfactant is 5 to 20: 0.5 to 5 : The emulsified composition which is 0.8-7.

(Item 5)
Item 5. The emulsified composition according to any one of Items 1 to 4, wherein a concentration of the oily component is 15 to 20% by weight, a concentration of the lecithin is 1.7 to 2.1% by weight, An emulsified composition having a surfactant concentration of 0.8 to 1.2% by weight.
(Item 6)
Item 5. The emulsified composition according to any one of Items 1 to 4, wherein a concentration of the oily component is 8 to 12% by weight, a concentration of the lecithin is 0.7 to 1.1% by weight, An emulsified composition having a surfactant concentration of 0.8 to 1.2% by weight.
(Item 7)
5 to 20 wt% oily component, 0.5 to 5 wt% lecithin, and 0.5 to 5 wt% nonionic surfactant having an HLB value of 13 to 17 and 5 to 25 wt% polyvalent An emulsified composition emulsified by a high-pressure emulsification method containing alcohol.
(Item 8)
5 to 20 wt% oily component, 0.5 to 5 wt% lecithin, and 0.5 to 5 wt% nonionic surfactant having an HLB value of 13 to 17 and 5 to 25 wt% polyvalent An emulsified composition containing alcohol and having a transparency of 0.3 or more.
(Item 9)
Item 9. The emulsion composition according to Item 8, wherein the transparency is 0.8 or more.
(Item 10)
The emulsified composition according to any one of Items 7 to 9, wherein a weight ratio of the oil component, the lecithin, the surfactant, and the polyhydric alcohol is 8 to 20 : Emulsified composition which is 0.8-2: 0.8-2: 12-18.
(Item 11)
The emulsified composition according to any one of Items 1 to 10, wherein the oily component is selected from squalane and behenyl alcohol.
(Item 12)
The emulsified composition according to any one of Items 1 to 10, wherein the nonionic surfactant having an HLB value of 13 to 17 is a polyoxyethylene sorbitan fatty acid ester.
(Item 13)
The emulsified composition according to any one of Items 7 to 10, wherein the polyhydric alcohol is selected from the group consisting of glycerin, 1,3-butylene glycol, and 1,2-pentanediol.
(Item 14)
The emulsified composition according to any one of Items 1 to 13, wherein the lecithin is hydrogenated lecithin.
(Item 15)
Item 13. The emulsion composition according to Item 12, wherein the polyoxyethylene sorbitan fatty acid ester is polyoxyethylene sorbitan monostearate (20E.O.).
(Item 16)
The following properties as indicators of transparency:
a) The transparency of the emulsified composition is 0.4 degree or more;
b) the transparency of an aqueous solution of 10% by volume of the emulsion composition is 0.6 degrees or more; or c) the transparency of an aqueous solution of the 1% by volume of the emulsion composition is 5 degrees or more;
The emulsified composition according to any one of items 1, 2, 6, 7 or 8, which has at least one of the following.
(Item 17)
The emulsified composition according to any one of Items 1 to 16, wherein the average particle size is 50 nm or less.

  According to the present invention, an emulsion composition having a high oil component content, particularly an emulsion composition having an oil component content of 3% or more is provided.

  The present invention will be described below. The terms used in this specification should be used in the meaning normally used in the art unless otherwise specified. Thus, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

(Definition of terms)
As used herein, the term “emulsification” refers to a phenomenon in which an aqueous component and an oily component are mixed to form an emulsion.

  As used herein, the term “emulsified composition” refers to a liquid or semi-solid, solid mixture that does not dissolve in each other, such as an oily component and a water-soluble component.

  As used herein, the term “high pressure emulsification method” refers to creating a finer and more stable emulsion by passing a mixture of an oily component and a water-soluble component through a narrow gap at a very high pressure of 10 MPa or more. Say the method. Examples of the equipment for performing the high pressure emulsification method include, but are not limited to, a gorin homogenizer type and a microfluidizer type.

  As used herein, the term “aqueous component” refers to a component that can be dissolved and / or diluted with water.

  As used herein, the term “oil component” refers to a substance that is liquid or solid at room temperature, is insoluble in water, is viscous, has a specific gravity less than water, and burns.

Examples of the “oil component” used in the present invention include, but are not limited to, a substance selected from the group consisting of:
Avocado oil, almond oil, olive oil, camellia oil, sesame oil, rice bran oil, safflower oil, soybean oil, corn oil, rapeseed oil, kyounin oil, persic oil, peach seed oil, castor oil, sunflower oil, grape seed oil, cottonseed oil, coconut oil , Wheat germ oil, rice germ oil, evening primrose oil, hybrid sunflower oil, macadamia nut oil, meadow foam oil, hazelnut oil, palm kernel oil, palm oil, palm oil, cacao butter, shea butter, wax, mink oil, Oils such as turtle oil, egg yolk oil, beef tallow, milk fat, pork fat, field oil, or waxes such as jojoba oil, carnauba wax, candela wax, rice bran, orange raffi oil, beeswax, shellac, lanolin, montan wax , Or squalene, squalane, liquid paraffin, paraffin, microcrystalline wax, sesame , Hydrocarbons such as soft liquid isoparaffin, hydrogenated polyisobutylene, ozokerite, ceresin, α-oleinphine oligomer, polybutene, polyethylene, or lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, hydroxystearic acid, Higher fatty acids such as oleic acid, linoleic acid, ethylhexanoic acid, isostearic acid, isopalmitic acid, isotridecanoic acid, isononanoic acid, pentadecanoic acid, or lauryl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, cetanol, oleyl alcohol, Lanolin alcohol, cholesterol, isocholesterol, sitosterol, stigmasterol, isostearyl alcohol, octyldodecanol, hexyldecanol, etc. Higher alcohols, or isopropyl myristate, isopropyl palmitate, butyl stearate, ethyl oleate, cetyl palmitate, myristyl myristate, octyldodecyl myristate, octyldodecyl oleate, cholesteryl stearate, cholesteryl hydroxystearate, tricaprin , Trimyristin, trioctanoin, isopropyl isostearate, isopropyl isostearate, ethyl isostearate, cetyl ethylhexanoate, stearyl ethylhexanoate, glyceryl triethylhexanoate, glyceryl triethylhexanoate, trimethylolpropane triethylhexanoate, tetraethylhexanoic acid Pentaerythryl, glyceryl triisostearate, triisostearate Esters such as methylolpropane, pentaerythritol tetraisostearate, pentaerythryl triisostearate, isocetyl isostearate, octyldodecyl dimethyloctanoate, myristyl lactate, cetyl lactate, trioctyldodecyl citrate, diisostearyl malate, and A mixture containing two or more of these.

  Of these oily components, squalane and behenyl alcohol are preferred. As a compounding quantity of an oil-based component, Preferably, it is 3 weight% or more with respect to the whole emulsion composition, More preferably, it is 5-20 weight%.

  As the surfactant having an HLB value of 13 to 17 used in the present invention, any of a nonionic surfactant, an amphoteric surfactant, a cationic surfactant, and an anionic surfactant can be used. However, it is preferable to use a nonionic surfactant.

The term “HLB value” used in the present specification is an abbreviation for the hydrophilic / lipophilic balance value, and is one of the indices representing the effect of the surfactant. Generally, the larger the “HLB value”, the stronger the hydrophilicity, and the smaller the “HLB value”, the stronger the lipophilicity. The HLB value is a semi-quantitative value based on experience. As an example of obtaining the HLB value experimentally, it can be obtained by the following method.
(1) Adjust the following emulsion formulation:
Sorbitan monostearate or polyoxyethylene sorbitan monostearate (20E.O.): X (% by weight)
Measurement sample: 4-X (% by weight)
Liquid paraffin # 70: 40 (% by weight)
Water: 56 (wt%)
(2) Create a prescription composition by arbitrarily changing the value of X as described above, and substituting the value of X when showing an excellent emulsified state into the following formula to obtain the HLB of the measurement sample Can do.
HLB of measurement sample = {4 × (required HLB of liquid paraffin) −X × (HLB of surfactant)} ÷ (4-X)
Required HLB for liquid paraffin = 10.1
Surfactant (sorbitan monostearate) HLB = 4.7
HLB of surfactant (polyoxyethylene sorbitan monostearate (20E.O.)) = 14.9
The HLB value can also be obtained by substituting some of the following well-known expressions.
(1) Atlas method: = 20 {1- (S / A)}. S is the saponification value of the ester and A is the acid value of the fatty acid;
(2) Griffin formula: HLB = 20 × (weight% of hydrophilic group); and (3) Davis formula: HLB = 7 + Σ (number of hydrophilic groups) −Σ (number of hydrophobic groups).
Among these formulas, the preferred formula is (3) Davis formula, but the method of obtaining HLB experimentally is more preferred. The preferable HLB value of the surfactant of the present invention is 13-17. More preferably, HLB is 14-15. The amount of the surfactant having an HLB value of 13 to 17 is preferably 0.1 (wt%) or more, more preferably 0.5 to 5 (wt%) based on the whole emulsion composition. preferable.

Nonionic surfactants used in the present invention include, but are not limited to, for example, the following substances:
Polyhydric alcohols such as propylene glycol mono fatty acid ester, ethylene glycol mono fatty acid ester, ethylene glycol mono fatty acid ester, glycerin mono fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, methyl glucoside fatty acid ester, alkyl polyglucoside Fatty acid esters, or polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene phytosterol, polyoxyethylene phytostanol, polyoxyethylene cholesterol, polyoxyethylene cholestanol, polyoxyethylene polyoxypropylene alkyl ether, Polyoxyethylene such as polyoxyethylene polyoxypropylene glycol Ethers, or polyoxyethylene mono fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxymethyl glucoside fatty acid ester, polyoxyethylene castor oil / hardened castor oil, polyoxyethylene animal and vegetable oil, polyoxyethylene Ether esters such as alkyl ether fatty acid esters, or nitrogen-containing derivatives such as polyoxyethylene alkylamines, polyoxyethylene fatty acid amides, alkyl diethanolamides, alkylamine oxides, and sulfur-containing derivatives such as polyoxyethylene alkyl mercaptans As well as mixtures containing two or more of these substances.

  Of these surfactants, polyoxyethylene sorbitan fatty acid esters are preferable, and among polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan monostearate having an HLB value of 13 to 17 is preferable. More preferred is polyoxyethylene sorbitan monostearate (20E.O.).

  As used herein, the term “lecithin” refers to phosphatidylcholine and its derivatives. Examples of lecithin used in the present invention include, but are not limited to, soy lecithin and egg yolk lecithin, purified lecithin and hydrogenated lecithin prepared from these natural lecithins, and 2 of these lecithins. A mixture containing more than one species. A preferred lecithin for use in the present invention is hydrogenated lecithin.

  As used herein, the term “hydrogenated lecithin” is used interchangeably with “hydrogenated lecithin” and refers to lecithin reduced by adding hydrogen to the unsaturated bond of lecithin.

  The blending amount of lecithin is preferably 0.1% by weight or more, more preferably 0.5 to 5% by weight, based on the whole emulsion composition.

The emulsion composition of the present invention may contain “polyhydric alcohol” as necessary. As used herein, the term “polyhydric alcohol” refers to an alcohol obtained by substituting a plurality of hydrogen atoms of a hydrocarbon with a hydroxyl group (—OH). Examples of the polyhydric alcohol used in the present invention include, but are not limited to, the following substances:
Propylene glycol, 1,3-butylene glycol, isoprene glycol, polyethylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol and other dihydric alcohols, or glycerol, etc. Alcohols, polyhydric alcohols such as polyglycerin, sugar alcohols such as sorbitol and xylitol, and mixtures containing two or more of these substances.

  Of these polyhydric alcohols, 1,3-butylene glycol, 1,2-pentanediol, and glycerin are preferable.

  When the polyhydric alcohol is blended in the emulsion composition of the present invention, the blending amount is preferably 0.1% by weight or more, more preferably 5 to 25% by weight based on the whole emulsion composition. .

  As used herein, the term “permeability” is an index that indicates the degree of see-through of a sample solution, and refers to a numerical value that can be measured with a fluorometer. Describe the height (cm) of the sample solution as “degrees” when the doublet of the sign board is confirmed by sinking a 20-character sign board on the fluorometer and draining it from the lower outlet. It is a numerical value.

  The emulsified composition of the present invention is 0.3 or more, preferably 0.4 or more, more preferably 0.5 or more, still more preferably 0.6 or more, still more preferably 0.7 or more, and even more preferably 0.00. It has a transparency of 8 or more, most preferably 0.9 or more.

  The emulsified composition of the present invention can be provided by emulsifying a mixture of an oily component and a water-soluble component by a high-pressure emulsification method. The type of the high-pressure emulsifier used in the high-pressure emulsification method of the present invention and the reaction temperature Any conditions such as the number of treatments and the pressure applied to the high-pressure emulsification treatment unit are not limited. A preferable pressure is 10 MPa or more.

  As the microfluidizer type high-pressure emulsifier, for example, a microfluidizer manufactured by Microfluidic Corporation can be used. The reaction temperature is not particularly limited, but in consideration of production efficiency, the high-pressure emulsifier is used after heating and melting to about 60 ° C. to 90 ° C., which is a temperature at which the mixture of the oil-soluble component and the water-soluble component before emulsification melts. It is preferable to react at a temperature of about 30 ° C. to 80 ° C. during the treatment. Moreover, it is although it does not specifically limit about the frequency | count of a process, It is preferable to process 2-5 times when manufacturing efficiency and the emulsified state of the emulsion composition manufactured are considered. Although it does not specifically limit about the pressure concerning a high-pressure emulsification process part, It is preferable to process by the pressure of 50-300 Mpa.

  For the emulsion composition of the present invention produced by the above method, water, fats and oils, waxes, hydrocarbons, silicones, fats, alcohols, esters, surfactants, thickeners, etc. In addition to these base materials, active ingredients of pharmaceuticals and quasi-drugs, pH adjusters, preservatives, pigments, fragrances, antioxidants, naturally derived extracts, sugars, or taste modifiers are added as necessary can do.

  The emulsified composition of the present invention can be used as an external preparation for skin, foods and pharmaceuticals. The shape of the external preparation for skin, food and medicine is not particularly limited. Any shape can be selected according to the purpose of use. For example, it can be used in the form of liquid, gel, cream, granule, solid, gas such as aerosol. When using the emulsified composition of the present invention as a skin external preparation, the emulsified composition of the present invention is used as it is, or added, diluted and then added to make up the skin lotion, cream, gel, ointment, emulsion, It can be added to cosmetics, quasi-drugs, cleansing agents, hair care agents, soaps, bath preparations, shampoos, rinses, lipsticks, lipsticks, foundations, and other cosmetics, quasi-drugs, and pharmaceuticals.

  Hereinafter, the present invention will be described in detail with reference to examples and the like, but the present invention is not limited thereto.

(Example 1: Preparation of emulsified composition A1 and emulsified composition A2)
Emulsion composition A1 was prepared by the method of the present invention using a high-pressure emulsification method, and emulsion composition A2 was prepared by a conventional method. The prescription and preparation procedure of emulsified composition A1 and emulsified composition A2 are shown below.
(Prescription)
(A) Behenyl alcohol: 2.5 (% by weight)
(B) Hydrogenated lecithin: 0.9 (% by weight)
(C) Squalane: 7.5 (% by weight)
(D) Methyl polysiloxane: 0.5 (% by weight)
(E) Polyoxyethylene sorbitan monostearate (20 EO): 1 (% by weight)
(F) Glycerin: 7 (% by weight)
(G) 1,3-butylene glycol: 5 (% by weight)
(H) Polyoxyethylene methyl glucoside: 2.5 (% by weight)
(I) 1,2-pentanediol: 3 (% by weight)
(J) Purified water was prepared so that the total amount was 100% as the remainder.

(Preparation of emulsion composition A1 by the method of the present invention using the high-pressure emulsification method)
(A) to (e) and (f) to (j) were separately heated, mixed at 80 ° C., and emulsified using a microfluidizer (manufactured by Microfluidic Corporation) of a high-pressure emulsifier. The pressure applied to the processing unit was set to 100 MPa. This high-pressure emulsification treatment was performed 2 to 5 times to prepare an emulsified composition A1.

(Preparation of emulsion composition A2 by a conventional method)
In order to compare with emulsion composition A1 of this invention, emulsion composition A2 was prepared by the conventional method. (A) to (e) and (f) to (j) were heated separately and emulsified using a homomixer to prepare an emulsified composition A2.

(Example 2: Preparation of emulsion composition B1 and emulsion composition B2)
In order to show that the method of the present invention is not limited to a specific formulation, the method of the present invention was compared with the conventional method using a formulation different from Example 1. Emulsion composition B1 was prepared by the method of the present invention using a high-pressure emulsification method, and emulsion composition B2 was prepared by a conventional method. The prescription and preparation procedure of emulsified composition A1 and emulsified composition A2 are shown below.
(Prescription)
(A) Behenyl alcohol: 2.5 (% by weight)
(B) Hydrogenated lecithin: 1.9 (% by weight)
(C) Squalane: 15 (% by weight)
(D) Methyl polysiloxane: 0.5 (% by weight)
(E) Polyoxyethylene sorbitan monostearate (20 EO): 1 (% by weight)
(F) Glycerin: 7 (% by weight)
(G) 1,3-butylene glycol: 5 (% by weight)
(H) Polyoxyethylene methyl glucoside: 2.5 (% by weight)
(I) 1,2-pentanediol: 3 (% by weight)
(J) Purified water was prepared so that the total amount was 100% as the remainder.

(Preparation of emulsion composition B1)
(A) to (e) and (f) to (j) were separately heated and melted, mixed at 80 ° C., and emulsified using a microfluidizer of a high-pressure emulsifier. The pressure applied to the processing unit was set to 100 MPa. Emulsion composition B1 was prepared by performing this high-pressure emulsification process 2 to 5 times.

(Preparation of emulsion composition B2)
In order to compare with the emulsion composition B1 of the present invention, (a) to (e) and (f) to (j) were heated separately and emulsified using a homomixer to prepare an emulsion composition B2. .

(Example 3: Observation of emulsion compositions A1, A2, B1, and B2)
In FIG. 1, the photograph (right) of emulsion composition A1 and the photograph (left) of emulsion composition A2 are shown. In FIG. 2, the photograph (right) of emulsion composition B1 and the photograph (left) of emulsion composition B2 are shown.

  As shown in the photographs of FIGS. 1 and 2, the emulsified composition A1 and the emulsified composition B1 of the present invention prepared by the high-pressure emulsification method are the same as the emulsified composition A2 and the emulsified composition prepared by the conventional method (homomixer). Clearly higher transparency than B2. In addition, the emulsified composition A1 and the emulsified composition B1 had an oily feeling greatly suppressed as compared to the emulsified composition A2 and the emulsified composition B2, and had a tactile feel like water. In terms of properties, the emulsified compositions A2 and B2 were gel, whereas the emulsified compositions A1 and B1 were completely liquid.

(Example 4: Stability of emulsion compositions A1, A2, B1, and B2)
The stability of the emulsion compositions A1, A2, B1, and B2 was examined.

  Emulsified compositions A1, A2, B1, and B2 were stored for 6 months at a temperature of 40 ° C. and a humidity of 75%. The emulsified compositions A1 and B1 of the present invention remain stable with no change in appearance and tactile sensation after being stored for 6 months under conditions of a temperature of 40 ° C. and a humidity of 75%. Showed excellent long-term stability.

(Example 5: Measurement of average particle size of emulsion compositions A1, A2, B1, and B2)
Table 1 shows the average particle diameters of the emulsified compositions A1, A2, B1 and B2. The average particle size was measured with a particle size distribution analyzer after dissolving the emulsified composition with an appropriate amount of water.

Emulsified compositions A1 and B1, which are the emulsified compositions of the present invention, clearly showed smaller average particle diameters compared with the emulsified compositions A2 and B2.

(Example 6: Measurement of transparency of emulsion compositions A1 and B1)
Table 2 shows the transparency of the emulsified compositions A1 and B1. The transparency was measured with a transparency meter without diluting the emulsion composition, after dilution to 10 (volume%), and after dilution to 1 (volume%).

As shown in the above table, the emulsified compositions A1 and B1 of the present invention exhibited excellent transparency.

(Example 7: High temperature stability test of emulsion compositions A1 and B1)
In order to confirm the stability of the emulsified compositions A1 and B1 at high temperatures, the emulsified compositions A1 and B1 were heated and their appearances were compared. Specifically, the following processing was performed:
1) Emulsified composition A1 and emulsified composition B1 were heated at a temperature of 80 ° C. for 30 minutes;
2) After heating, cooled to room temperature;
3) After cooling, the appearance was compared with an emulsified composition that was not heat-treated.

  As a result after the heating, FIG. 3 shows a photograph (left) of the emulsion composition A1 before the heat treatment and a photograph (right) of the emulsion composition A1 after the heat treatment. Similarly, in FIG. 4, the photograph (left) of the emulsion composition B1 before heat processing and the photograph (right) of the emulsion composition B1 after heat processing are shown. As shown in FIGS. 3 and 4, there was no difference in the appearance of the emulsified compositions A1 and B1 before and after heating.

  Next, the particle size distribution before and after heating was compared for the emulsion composition A1. FIG. 5 shows the particle size distribution before heating, and FIG. 6 shows the particle size distribution after heating. As is clear from these results, no difference was observed between the particle size distribution of the emulsified composition A1 after the heating test and the particle size distribution of the emulsified composition A1 before the heating. The average particle size after the heating test was 64.1 nm, and no significant change was observed compared to before heating. Therefore, it became clear that the emulsified composition of the present invention maintains a stable emulsified state even under high temperature conditions.

(Example 8: versatility of the emulsion composition of the present invention in various dosage forms)
The emulsified composition of the present invention can be used as a cosmetic liquid as it is, but it was investigated whether the emulsified composition of the present invention has applicability in other commonly used dosage forms. .

(1: Preparation of gel cream)
The preparation method of the gel cream containing the emulsion composition of this invention is shown.
(Prescription)
(A) Behenyl alcohol: 1.8 (% by weight)
(B) Hydrogenated lecithin: 1.4 (% by weight)
(C) Squalane: 11.0 (% by weight)
(D) Methyl polysiloxane: 0.37 (% by weight)
(E) Polyoxyethylene sorbitan monostearate (20E.O.): 0.37 (% by weight)
(F) Glycerin: 5.2 (% by weight)
(G) 1,3-butylene glycol: 3.7 (% by weight)
(H) Polyoxyethylene methyl glucoside: 1.8 (% by weight)
(I) 1,2-pentanediol: 2.2 (% by weight)
(J) Purified water: 45.0 (% by weight)
(K) Carboxyvinyl polymer 0.5
(L) Potassium hydroxide 0.19
(M) Purified water was prepared so that the total amount was 100% as the remainder.

(Preparation of gel cream emulsion composition C1)
(A) to (e) and (f) to (j) were separately heated and melted, mixed at 80 ° C., and emulsified using a microfluidizer (manufactured by Microfluidic Corporation) of a high-pressure emulsifier. The pressure applied to the processing unit was set to 100 MPa. The emulsified composition containing (a) to (j) was prepared by performing this high-pressure emulsification treatment 2 to 5 times. The emulsion composition of (a) to (j) was stirred so as to be uniform with the mixture of (k) to (m) to prepare a gel cream containing the emulsion composition of the present invention. Thus, the gel cream which mix | blended the emulsion composition of this invention was able to be prepared.

(2: Preparation of lotion)
The preparation method of the skin lotion containing the emulsion composition of this invention is shown.
(Prescription)
(A) Behenyl alcohol: 1.3 (% by weight)
(B) Hydrogenated lecithin: 0.45 (% by weight)
(C) Squalane: 3.8 (% by weight)
(D) Methyl polysiloxane: 0.25 (% by weight)
(E) Polyoxyethylene sorbitan monostearate (20E.O.): 0.50 (% by weight)
(F) Glycerin: 3.5 (% by weight)
(G) 1,3-butylene glycol: 2.5 (% by weight)
(H) Polyoxyethylene methyl glucoside: 1.3 (% by weight)
(I) 1,2-pentanediol: 1.5 (% by weight)
(J) Purified water: 35.1 (% by weight)
(K) Ethanol: 15 (% by weight)
(L) Purified water was prepared so that the total amount was 100% as the remainder.

(Preparation of emulsion composition D1)
(A) to (e) and (f) to (j) were separately heated and melted, mixed at 80 ° C., and emulsified using a microfluidizer (manufactured by Microfluidic Corporation) of a high-pressure emulsifier. The pressure applied to the processing unit was set to 100 MPa. The emulsified composition containing (a) to (j) was prepared by performing this high-pressure emulsification treatment 2 to 5 times. The emulsified composition of (a) to (j) was stirred so as to be uniform with the mixture of (k) to (l) to prepare a lotion containing the emulsified composition of the present invention. Thus, the skin lotion which mix | blended the emulsion composition of this invention was able to be prepared.

  As mentioned above, although this invention has been illustrated using preferable embodiment of this invention, this invention should not be limited and limited to this embodiment. It is understood that the scope of the present invention should be construed only by the claims. It is understood that those skilled in the art can implement an equivalent range based on the description of the present invention and the common general technical knowledge from the description of specific preferred embodiments of the present invention. Patents, patent applications, and documents cited herein should be incorporated by reference in their entirety, as if the contents themselves were specifically described herein. Understood.

  By using the emulsified composition of the present invention as an external preparation for skin, foods, and pharmaceuticals, despite containing a large amount of oily components, it is highly transparent, and also excellent in stability at high temperatures, Furthermore, it is possible to provide an emulsified composition having a feeling of use.

FIG. 1 is a photograph showing emulsified composition A1 (right) and emulsified composition A2 (left). FIG. 2 is a photograph showing emulsion composition B1 (right) and emulsion composition B2 (left). FIG. 3 is a photograph showing the emulsion composition A1 (left) before the heat treatment and the emulsion composition A1 (right) after the heat treatment. FIG. 4 is a photograph showing the emulsion composition B1 (left) before the heat treatment and the emulsion composition B1 (right) after the heat treatment. FIG. 5 is a graph showing the particle size distribution before heating for the emulsified composition A1. FIG. 6 is a graph showing the particle size distribution of the emulsified composition A1 after heating at 80 ° C. for 30 minutes.

Claims (17)

  It is emulsified by a high-pressure emulsification method containing 3 to 30% by weight of an oily component, 0.1 to 10% by weight of lecithin, and 0.1 to 10% by weight of a surfactant having an HLB value of 13 to 17. Emulsified composition.   3 to 30% by weight of an oil component, 0.1 to 10% by weight of lecithin, and 0.1 to 10% by weight of a surfactant having an HLB value of 13 to 17 and having a transparency of 0.3 That is the emulsified composition.   The emulsified composition according to claim 2, wherein the transparency is 0.8 or more.   It is an emulsion composition as described in any one of Claims 1-3, Comprising: Here, the weight ratios of the said oil-based component, the said lecithin, and the said surfactant are 5-20: 0.5-. 5: Emulsion composition which is 0.8-7.   It is an emulsion composition as described in any one of Claims 1-4, Comprising: Here, the density | concentration of the said oil-based component is 15-20 weight%, The density | concentration of the said lecithin is 1.7-2.1 weight%, The emulsion composition whose density | concentration of the said surfactant is 0.8-1.2 weight%.   It is an emulsion composition as described in any one of Claims 1-4, Comprising: Here, the density | concentration of the said oil component is 8-12 weight%, The density | concentration of the said lecithin is 0.7-1.1 weight%, The emulsion composition whose density | concentration of the said surfactant is 0.8-1.2 weight%.   5 to 20 wt% oily component, 0.5 to 5 wt% lecithin, and 0.5 to 5 wt% nonionic surfactant having an HLB value of 13 to 17 and 5 to 25 wt% polyvalent An emulsified composition emulsified by a high-pressure emulsification method containing alcohol.   5 to 20 wt% oily component, 0.5 to 5 wt% lecithin, and 0.5 to 5 wt% nonionic surfactant having an HLB value of 13 to 17 and 5 to 25 wt% polyvalent An emulsified composition containing alcohol and having a transparency of 0.3 or more.   The emulsified composition according to claim 8, wherein the transparency is 0.8 or more.   It is an emulsified composition as described in any one of Claims 7-9, Comprising: Here, the weight ratio of the said oil-based component, the said lecithin, the said surfactant, and the said polyhydric alcohol is 8 ~. Emulsifying composition which is 20: 0.8-2: 0.8-2: 12-18.   The emulsified composition according to any one of claims 1 to 10, wherein the oily component is selected from squalane and behenyl alcohol.   The emulsified composition according to any one of claims 1 to 10, wherein the nonionic surfactant having an HLB value of 13 to 17 is a polyoxyethylene sorbitan fatty acid ester.   The emulsion composition according to any one of claims 7 to 10, wherein the polyhydric alcohol is selected from the group consisting of glycerin, 1,3-butylene glycol, and 1,2-pentanediol.   The emulsified composition according to any one of claims 1 to 13, wherein the lecithin is hydrogenated lecithin.   The emulsion composition according to claim 12, wherein the polyoxyethylene sorbitan fatty acid ester is polyoxyethylene sorbitan monostearate (20EO). The following properties as indicators of transparency:
a) The transparency of the emulsified composition is 0.4 degree or more;
b) the transparency of an aqueous solution of 10% by volume of the emulsion composition is 0.6 degrees or more; or c) the transparency of an aqueous solution of the 1% by volume of the emulsion composition is 5 degrees or more;
The emulsified composition according to any one of claims 1, 2, 6, 7, or 8 having at least one of the following:   The emulsified composition according to any one of claims 1 to 16, wherein the average particle size is 100 nm or less.