JP2007231012A - Bleaching agent composition for teeth - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a bleaching agent composition which is used for teeth, has both high safety and high bleaching performance, and is also useful from the aspect of generality. <P>SOLUTION: This bleaching agent composition for teeth is characterized by comprising an aqueous emulsion component which can react with a calcium compound having an average particle diameter of <3 μm to form coagulated particles having particle diameters of ≥3 μm, a water-soluble organic acid and/or its water-soluble salt component (but, the calcium salt of the water-soluble organic acid is insoluble or slightly soluble in water), and/or a sulfate component, and a persulfuric acid-based bleaching agent. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a tooth bleaching composition. More specifically, the present invention relates to a tooth bleaching composition having high safety and high bleaching performance.

In recent years, the number of patients seeking improvement in the aesthetics of discolored and colored teeth is increasing due to the improvement of consciousness regarding aesthetics in the oral cavity. Conventionally, in order to improve these aesthetics, a treatment in which a certain amount of tooth is removed and replaced with an artificial object using a technique such as a crown prosthesis or a laminate veneer has been mainly performed.
However, with these treatments, many tooth structures are deleted only for aesthetic reasons, and since teeth are also a tissue that cannot be regenerated, the minimal intervention (minimum intervention) that has become a trend in recent dental treatments. This is incompatible with the concept of invasiveness.
In such a situation, the tooth bleaching method has come to be frequently used as an aesthetic recovery means that does not delete teeth at all. As a tooth bleaching method, the walking bleach method in which a mixture of sodium perborate and high-concentration (30-35%) hydrogen peroxide solution is encapsulated in the medullary cavity and bleached for unmyelinated teeth. In contrast, the office bleaching method in which bleaching is performed in a dental clinic using high-concentration (30-35%) hydrogen peroxide, and the patient himself at home using relatively low concentration (10-22%) urea peroxide. There is a home bleaching method to bleach.
However, in the walking bleach method and the office bleach method, a high concentration hydrogen peroxide solution, which is a powerful drug, is used in the oral cavity, so there is a concern about safety. In the home bleaching method, relatively low concentrations of urea peroxide are bleached by gradually decomposing with water in the mouth and generating hydrogen peroxide, so the concentration of hydrogen peroxide that actually acts on the tooth surface is It has a problem that it is low, the processing time until the bleaching effect is exhibited is long, and the bleaching effect is low.

On the other hand, the bleaching method using a peroxygen bleach composition such as hydrogen peroxide is a well-known method in the technical field of garment cleaning agents, and is one of the main components contained in current detergents and cleaning agents. One. Its main function is to remove stubborn stains such as tea, tea, coffee or red wine from the spun fibers or solid surfaces. This removal action is achieved by the oxidative decomposition action of the attached dye, and at the same time, the attached microorganisms are killed and malodorous substances are also decomposed (see Patent Document 1).
However, a peroxide compound that releases hydrogen peroxide in an aqueous solution for washing clothes has poor bleaching power, and a short bleaching treatment cannot provide a sufficient bleaching effect, particularly at low temperatures. In order to obtain the bleaching effect, there is a disadvantage that a long treatment is required.
In the field of garment detergents, various proposals have been made to activate peroxides in order to make the bleach usable at low temperatures. One proposal is a so-called organic bleach activator that reacts with peroxides such as sodium perborate and sodium percarbonate in solution to form organic peroxy acids with high bleaching activity at low temperatures ( Patent Document 2).

Teeth are also considered to be discolored due to the deposition of pigments contained in food and drink such as coffee and tea, or the deposition of cigarette dust. The walking bleaching and office bleaching methods currently considered require a long processing time, sometimes require light irradiation, and the low bleaching action is effective even with high concentrations of hydrogen peroxide or urea. It is presumed that the seeds are not generated.
As another method for efficiently generating active species from hydrogen peroxide, a method using titanium dioxide is disclosed (see Patent Document 3), but a light source for photoactivation of hydrogen peroxide is indispensable. Therefore, it cannot be said to be a versatile method in use.
As another method for efficiently generating active species from peroxide, an example using a transition metal compound is also known (see Patent Document 4). However, such a transition metal compound is often harmful to the human body and is not preferable from the viewpoint of safety as a tooth bleaching agent applied to human teeth. As yet another example, a tooth bleaching method (see Patent Document 5) using a composition comprising a specific organic peracid compound and an iminium salt is disclosed. However, in this bleaching system, the addition of an organic peracid compound in addition to the iminium salt is essential due to its structure, and formulation and handling during use must be complicated.

On the other hand, a conventional tooth bleaching method using a low-concentration hydrogen peroxide solution is disclosed in Patent Document 2. This method uses a mixture of a hydrogen peroxide solution having a concentration of about 3% or a paste thereof and titanium dioxide powder as a photocatalyst. And bleach. In this method, because titanium dioxide catalyzes by light energy based on light irradiation, decomposition of hydrogen peroxide is promoted to generate active oxygen, and the tooth surface is bleached by the oxidizing power of active oxygen. Can do.
JP-A-6-269676 Japanese Patent Laid-Open No. 60-237042 Japanese Patent Laid-Open No. 11-092351 US Pat. No. 5,648,064 US Pat. No. 6,165,448

  An object of the present invention is to provide a dental bleaching composition that solves the above-mentioned problems of the prior art, has both high safety and bleaching performance, and is useful from the viewpoint of versatility.

  Other objects and advantages of the present invention will become apparent from the following description.

  As a result of intensive investigations aimed at achieving the above-mentioned object regarding tooth bleaching, the present inventors have found that a specific composition has high safety and bleaching performance, and have completed the present invention.

That is, according to the present invention, the above objects and advantages of the present invention are as follows.
(AB) water-insoluble, poorly water-soluble or a component capable of forming a Ca salt that becomes aggregated particles in water, and (C) a persulfate bleach.
It is achieved by a tooth bleaching composition characterized by containing

  The tooth bleaching composition of the present invention does not necessarily require light irradiation, and can protect and bleach a surface with a low concentration peroxide in a short time.

  Details of the present invention will be described below.

The tooth bleaching composition of the present invention,
The tooth is bleached by applying it to the tooth surface containing (C) a persulfuric acid-based bleaching agent and (AB) a water-insoluble, poorly water-soluble or component capable of forming a Ca salt that forms aggregated particles in water. It is a composition.
The component (AB) that is water-insoluble, poorly water-soluble or capable of forming a Ca salt that becomes aggregated particles in water is not particularly limited.
(A) an aqueous emulsion component having an average particle size of less than 3 μm and capable of forming aggregated particles having a particle size of 3 μm or more by reacting with a calcium compound and / or
(B) a water-soluble organic acid component and / or a water-soluble salt component thereof (provided that the calcium salt of the water-soluble organic acid is water-insoluble or poorly water-soluble), and / or
(B ') A sulfate component can be mentioned as a preferable thing.
As a standard for water-insoluble or poorly water-soluble precipitation, it is generally desirable that the solubility of the calcium salt of component (B ′) in water at 25 ° C. is less than 0.5 g / 100 ml.

  When the component (AB) in the present invention becomes a calcium salt, it becomes a water-insoluble or sparingly soluble salt or a substance that causes precipitation in water (Ca salt). Water insolubility or poor solubility is determined by the presence or absence of precipitation when a solution containing the component (B) or (B ′) and a solution containing calcium ions are mixed. Presence or absence of precipitation can generally be known from the relationship between the solubility product and the ionic product. That is, when the ionic product of the calcium salt of the component (B) or (B ′) is equal to the solubility product, or when the ionic product is larger than the solubility product, the water hardly soluble and water insoluble can be obtained. As a guideline for simple precipitation, when a water-soluble organic acid or its water-soluble salt is mixed with an aqueous solution in the concentration range of 1 to 5% by weight and an aqueous calcium chloride solution in the same concentration range, the formation of the precipitate is visually confirmed. There is a way.

In addition, even if it is a substance that is water-insoluble or hardly soluble before forming a calcium salt and cannot form a complete aqueous solution, it can be treated as a quasi-homogeneous liquid for convenience by forming colloids, And if it is a substance which can form aggregate macroparticles by salting-out etc. by calcium ion, or precipitation may form, and can form a substantially macroscopic solid substance, this is also handled as a component (AB) of this invention. It is possible.
The component (A) in the present invention, which is such a component, is a polymer particle having an average particle size of less than 3 μm and capable of forming aggregated particles having a particle size of 3 μm or more by reacting with a calcium compound as emulsion particles. An aqueous emulsion component to be contained.

The component (A) is a polymer emulsion (sometimes referred to as latex), which is obtained by emulsifying or dispersing a natural resin or a synthetic resin in water. The component (A) includes emulsion particles in which the polymer particles being emulsified or dispersed have a particle size of less than 3 μm, and the emulsion particles react with a calcium compound to form aggregated particles having a particle size of 3 μm or more. It is characterized by being able to.
In order to effectively develop effects such as protecting the enamel of teeth from demineralization, it is effective that the average particle size of the emulsion particles of the polymer in the component (A) is less than 3 μm, and 1 μm Or less, more preferably 0.5 μm or less. It is presumed that this is because the aggregate formed from the component (A) firmly coats the enamel surface or penetrates deeply into enamel microcracks due to the particle size.

  Moreover, the same effect is recognized also about the dentin of a tooth. That is, in order for the aqueous emulsion to penetrate to a depth sufficient to seal the dentinal tubule, the particle size of the polymer emulsion particles needs to be smaller than the diameter of the dentinal tubule. The diameter of the dentinal tubule is usually in the range of 1 to 3 μm, although there are positions, depths, and individual differences. The diameter of the dentinal tubule is usually determined by scraping the enamel of the removed tooth and brushing the exposed dentin surface with a dentifrice and toothbrush for 1 minute or more, and then performing ultrasonic cleaning in water. It can be measured by observing with a scanning electron microscope (SEM).

Further, the particle size of the emulsion particles of component (A) has a distribution, and it is not necessary that the particle size of all the emulsion particles is less than 3 μm, and the weight average particle size may be the above-mentioned numerical value. Of the emulsion particles in the component (A), those having a particle size of less than 3 μm preferably occupy 50% by weight or more, and more preferably, the particle size of 90% by weight or more of the emulsion particles is less than 3 μm. In addition to the above conditions, among the emulsion particles of component (A), those having a particle size of 1 μm or less preferably occupy 65% by weight or more, particularly preferably 75% by weight or more. The object of the present invention is excellently achieved when the emulsion particles have the particle size distribution as described above.
The component (A) includes at least one functional group capable of reacting with a calcium compound selected from the group consisting of a carboxyl group, a group in which at least one hydroxyl group is bonded to a phosphorus atom, and a sulfonic acid group. Preferably, an emulsion of a copolymer having a (meth) acrylic acid alkyl ester component and a styrene sulfonic acid component as components constituting the copolymer is preferably used.

  Examples of the polymer that can be used as the component (A) include homopolymers and / or copolymers of radical polymerizable monomers. Examples of the radical polymerizable monomer include conjugated diene monomers such as butadiene and isoprene; aromatic vinyl monomers such as styrene, α-methylstyrene and chlorostyrene; vinyl cyanide monomers such as acrylonitrile and methacrylonitrile. (Meth) acrylic acid (hereinafter referred to as a generic term for acrylic acid and methacrylic acid) methyl (meth) acrylic acid alkyl esters such as methyl (meth) acrylate, butyl (meth) acrylate; Examples thereof include vinyl halides and vinylidene such as vinyl chloride, vinyl bromide, vinylidene chloride, and vinylidene bromide; vinyl esters such as vinyl acetate and vinyl propionate. These monomers are used for polymerization alone or in combination of two or more.

  The polymer synthesized from the radical polymerizable monomer preferably has a functional group capable of reacting with a calcium compound. Examples of the functional group capable of reacting with the calcium compound include a carboxyl group, a group in which at least one hydroxyl group is bonded to a phosphorus atom, and a sulfonic acid group. As a method of introducing the functional group, for example, a method of introducing a functional group into a polymer, a method represented by a method of sulfonating polystyrene, a method of hydrolyzing a polymer containing a carboxylic acid ester or a phosphate ester, And a radical polymerizable monomer having a functional group that can be easily converted into the above functional group or the above functional group in water. The last method is preferred. Examples of the radical polymerizable monomer having a functional group capable of reacting with a calcium compound include the following compounds.

Examples of the radically polymerizable monomer having a carboxyl group or a functional group that can be easily converted into a carboxyl group in water include monocarboxylic acid, dicarboxylic acid, tricarboxylic acid and tetracarboxylic acid, salts and anhydrides thereof. Can do. More specifically, α-unsaturated carboxylic acids such as (meth) acrylic acid and maleic acid; carboxylic acids with vinyl aromatic rings added such as p-vinylbenzoic acid; 11- (meth) acryloyloxy-1, Carboxylic acids such as 1-undecanedicarboxylic acid (MAC-10) in which a linear hydrocarbon group exists between the (meth) acryloyloxy group and the carboxylic acid group; 1,4-di (meth) acryloyloxyethyl pyromerit Carboxylic acids having an aromatic ring such as acid, 6- (meth) acryloyloxyethylnaphthalene-1,2,6-tricarboxylic acid; 4- (meth) acryloyloxymethyl trimellitic acid and its anhydride, 4- (meth ) Acryloyloxyethyl trimellitic acid and its anhydride, 4- (meth) acryloyloxybutyl trimellitic acid and its 4- (Meth) acryloyloxyalkyl trimellitic acid such as water and its anhydride; 4- [2-hydroxy-3- (meth) acryloyloxybutyl] trimellitic acid and its anhydride, etc. Carboxylic acid having a hydrophilic group such as, and its anhydride; Compound having a carboxybenzoyloxy group such as 2,3-bis (3,4-dicarboxybenzoyloxy) propyl (meth) acrylate; N, O-di (meta ) N- and / or O-mono or di (meth) acryloyloxyamino acids such as acryloyloxytyrosine, O- (meth) acryloyloxytyrosine, N- (meth) acryloyloxytyrosine, N- (meth) acryloyloxyphenylalanine; N- (meth) acryloyl-p-aminobenzoic acid, N- N- (meth) acryloylaminobenzoic acid such as (meth) acryloyl-o-aminobenzoic acid; 2 or 3 or 4- (meth) acryloyloxybenzoic acid, 2-hydroxyethyl (meth) acrylate and pyromellitic dianhydride Product addition product (PMDM), 2-hydroxyethyl (meth) acrylate and maleic anhydride or 3,3 ′, 4,4′-benzophenonetetracarboxylic dianhydride (BTDA) or 3,3 ′, 4 An addition reaction product of a hydroxyalkyl (meth) acrylate and an unsaturated polycarboxylic acid anhydride, such as an addition reaction product of 4′-biphenyltetracarboxylic dianhydride;
Compounds having polycarboxybenzoyloxy and (meth) acryloyloxy such as 2- (3,4-dicarboxybenzoyloxy) -1,3-di (meth) acryloyloxypropane; and N-phenylglycine or N-tolylglycine Adduct with glycidyl (meth) acrylate, 4-[(2-hydroxy-3- (meth) acryloyloxypropyl) amino] phthalic acid, 3 or 4- [N-methyl-N- (2-hydroxy-3-) And (meth) acryloyloxypropyl) amino] phthalic acid. Of these, 11-methacryloyloxy-1,1-undecanedicarboxylic acid (MAC-10) and 4-methacryloyloxyethyl trimellitic acid (4-MET) or its anhydride (4-META) are preferably used.

  As a group in which at least one hydroxyl group is bonded to a phosphorus atom and a functional group that can be easily converted into the group in water, for example, a phosphate ester group having one or two hydroxyl groups and a salt thereof are preferable. It can be illustrated. Examples of the polymerizable monomer having such a group include 2- (meth) acryloyloxyethyl acid phosphate, 2 and 3- (meth) acryloyloxypropyl acid phosphate, 4- (meth) acryloyloxybutyl acid phosphate, 6- (meth) acryloyloxyhexyl acid phosphate, 8- (meth) acryloyloxyoctyl acid phosphate, 10- (meth) acryloyloxydecyl acid phosphate, 12- (meth) acryloyl oxide decyl acid phosphate, bis {2- (meta ) Phosphoric acid ester having one or more (meth) acryloyloxyalkyl groups such as acryloyloxyethyl} acid phosphate, bis {2 or 3- (meth) acryloyloxypropyl} acid phosphate , 2- (meth) acryloyloxyethylphenyl acid phosphate, 2- (meth) acryloyloxyethyl-p-methoxyphenyl acid phosphate, etc., a linear hydrocarbon group exists between the (meth) acryloyloxy group and the phosphate group And phosphoric acid ester having an aromatic group. The compound which substituted the phosphate group in these compounds by the thiophosphate group can also be illustrated. Of these, 2- (meth) acryloyloxyethylphenyl acid phosphate and 10- (meth) acryloyloxydecyl acid phosphate are preferably used.

As a polymerizable monomer having a sulfonic acid group or a functional group that can be easily converted into sulfonic acid group in water, for example, 2-sulfoethyl (meth) acrylate, 2 or 1-sulfo-1 or 2-propyl (meth) acrylate Sulfoalkyl (meth) acrylates such as 1 or 3-sulfo-2-butyl (meth) acrylate; 3-bromo-2-sulfo-2-propyl (meth) acrylate, 3-methoxy-1-sulfo-2-propyl (Meth) acrylate having a sulfonic acid group on a hydrocarbon having a hetero-containing substituent (halogen, alkoxy, etc.) such as (meth) acrylate; sulfoalkyl such as 1,1-dimethyl-2-sulfoethyl (meth) acrylamide ( Examples include acids such as (meth) acrylamide and styrene sulfonic acid and their salts. That. Of these, 2-methyl-2- (meth) acrylamidepropanesulfonic acid or styrenesulfonic acid and salts thereof are preferably used.
The functional group that can react with the calcium compound or the functional group that can be easily converted into the functional group in water is preferably 0.00001 to 0.01 mol / g, more preferably 0.00002 to 0.01 mol / g in the emulsion. It exists at 0.005 mol / g.

  The number average molecular weight Mn of the polymer contained in the component (A) is preferably 3,000 or more, more preferably 7,000 or more, and further preferably 10,000 or more as a value measured by the GPC method. . The upper limit of the number average molecular weight is usually 5 million. The component (A) contains a polymer as emulsion particles, preferably in the range of 0.1 to 60% by weight, more preferably 0.5 to 40% by weight, still more preferably 1 to 20% by weight. Can do.

  A preferred component (A) is a molar ratio (alkyl acrylate) of (meth) acrylic acid alkyl ester units having 4 to 8 carbon atoms and styrene sulfonic acid units obtained by a polymerization method without using an emulsifier, so-called soap-free emulsion polymerization method. Ester unit / styrene sulfonic acid unit [mol / mol]) 50/50 to 99.5 / 0.5, more preferably 80/20 to 98.5 / 1.5, still more preferably 90/10 to 98 / 2 is an emulsion containing the copolymer contained in 2 as emulsion particles. A copolymer (herein below), which is a combination of monomers other than the copolymer (hereinbelow referred to as AA / SS polymer) comprising the (meth) acrylic acid alkyl ester unit and the styrene sulfonic acid unit. In the case of other polymer), the molar weight ratio [which is the ratio of the number of moles of functional groups (such as sulfonic acid) contained in the other polymer that can react with the calcium compound to the weight of the other polymer] Mol / g] corresponds to the molar range [mol / mol] in the case of the AA / SS polymer (provided that the AA / SS polymer is methyl acrylate / sodium styrene sulfonate). As a ratio). As this copolymer emulsion, for example, those disclosed in JP-A-6-57080 can be used. As a more preferred component (A), for example, the emulsion particles of the copolymer are dispersed in a high-speed mixer or homogenizer, preferably with a particle size of less than 3 μm, more preferably with a particle size of 1 μm or less, most preferably with a particle size of 0. It is possible to use emulsion particles having a dispersion stability of 5 μm or less, which are prepared so that the emulsion particles are present in the component (A) at 0.5% by weight or more. The emulsion particles of the copolymer having a particle size of 1.0 μm or less preferably occupy 50% by weight or more, more preferably 75% by weight or more, and occupy the whole emulsion particles. Is most preferred.

The emulsion particles having a particle size of less than 3 μm contained in the component (A) react with the calcium compound when a calcium compound, for example, calcium chloride, is added to the component (A) and have a particle size of 3 μm or more. Aggregated particles having the following can be formed.
Usually, the particle diameter of the aggregated particles exceeds 3 μm, preferably 10 μm or more, more preferably 50 to several thousand μm.
The amount of the calcium compound added is preferably in the range of 10 to 100 parts by weight with respect to 100 parts by weight of the nonvolatile component in the emulsion.
By using the component (A) having such properties in the composition of the present invention, small-diameter emulsion particles that have penetrated into the tooth surface or the crack surface of the tooth surface are dissolved in calcium aerated from hydroxyapatite present in the enamel. Reacts with ions to form a large number of large agglomerated particles.

The large number of large agglomerated particles formed form a continuously filled state (film). By forming such a state, the crack is blocked. The state in which the crack portion is blocked is quickly formed by using the component (B) of the present invention. In this state, the adhesiveness between the aggregated particles and the dentin is maintained for a long time, so that it is maintained for a long time.
The nonvolatile component in 100 parts by weight of component (A) is preferably 0.1 to 60 parts by weight, more preferably 0.5 to 40 parts by weight, and still more preferably 1 to 20 parts by weight. .
As described above, the component (B) in the tooth bleaching material adjusts the aggregation rate of the emulsion particles of the polymer contained in the component (A), that is, the rate of formation of the hardly soluble gel (aggregate), and (B ) When the component forms a calcium salt that is insoluble or sparingly soluble in water, it plays a role in improving the durability of the coating comprising a sparingly soluble gel.

  Further, the calcium salt of the component (B) is a crystal having various forms, and may generally exist in a spherical shape, a round shape having a relatively round shape, a plate shape, a needle shape, and the like. The size varies depending on the crystal form. Preferably, for example, a spherical or round shape has an average diameter of 0.1 to 10 μm, and a plate has an average side length of 0.1 to 10 μm. In the shape, the thickness ranges from 0.1 to 5 μm and the length ranges from 1 to 10 μm. The calcium salt having such a shape is present together with the hardly soluble aggregate (gel) generated from the component (A) on the surface of the tooth, and promotes the protection of the enamel surface and the blocking of the dentinal tubules, and the poorly soluble aggregate. It plays the role of reducing the volume shrinkage during the formation of aggregates or during drying. In addition, due to the blockage as described above, transmission of stimulation from the tooth surface can be blocked, and hypersensitivity can be suppressed.

The component (B) in the tooth bleaching material is a water-soluble organic acid or a water-soluble salt thereof, and the calcium salt of the organic acid is a water-insoluble or hardly soluble salt. Water insolubility or poor solubility is determined by the presence or absence of precipitation when a solution containing component (B) and a solution containing calcium ions are mixed. Presence or absence of precipitation can generally be known from the relationship between solubility product and ionic product. That is, when the ionic product of the calcium salt of the component (B) is equal to the solubility product, or when the ionic product is larger than the solubility product, it can be made hardly soluble in water and insoluble in water. As a guideline for simple precipitation, the formation of precipitates is visually confirmed when an aqueous solution of 1 to 5% by weight of a water-soluble organic acid or its water-soluble salt component is mixed with an aqueous solution of calcium chloride in the same concentration range. There is a way to do it.
As the component (B) in the tooth bleaching material, for example, oxalic acid or water-soluble oxalate selected from oxalic acid, metal oxalate, ammonium oxalate and amine oxalate; propionic acid, metal propionate Examples thereof include propionic acid or water-soluble propionate selected from a salt, ammonium propionate, and an amine salt of propionic acid.

  As a measure of water solubility, the solubility in water at 25 ° C. is 0.5 g / 100 ml or more. Specific examples of such compounds include oxalic acid, sodium hydrogen oxalate, sodium oxalate, potassium hydrogen oxalate, potassium oxalate, lithium hydrogen oxalate, lithium oxalate, ammonium hydrogen oxalate, ammonium oxalate, aniline oxalate, and oxalate. Examples thereof include potassium zinc oxide, aluminum oxalate, ammonium ammonium oxalate, sodium aluminum oxalate, antimony potassium oxalate, chromium potassium oxalate, barium hydrogen oxalate, and potassium iron oxalate. Of these, oxalic acid, potassium hydrogen oxalate and potassium iron oxalate are preferred.

In the tooth bleaching agent, the component (A) is preferably 50 to 99.5 parts by weight, more preferably 70 to 99 parts by weight, most preferably 90 to 90 parts by weight based on 100 parts by weight of the total of the components (A) and (B). It is in the range of 98 parts by weight. By being in this range, the effect of the present invention remarkably appears.
The blending amount of the component (B) of the tooth bleaching agent affects the size and precipitation amount of the calcium salt of the component (B). At a low concentration outside the above concentration range, the amount of precipitation is too small or the crystal size is too small, so that the expected effect may not be sufficiently exhibited. On the other hand, when the component (B) is at a high concentration outside the above range, it may reach the saturation concentration and precipitate from the solution, or the emulsion particles may be significantly aggregated.

The component (B ′) in the present invention is a sulfate salt that can form a water-insoluble or poorly water-soluble precipitate by reacting with the calcium compound (D).
In the present invention, an alkali metal sulfate compound and an ammonium sulfate compound are used as the component (B ′). Examples of such a compound include ammonium sulfate, ammonium hydrogen sulfate, sodium ammonium sulfate, and potassium ammonium sulfate. Among these, an ammonium sulfate compound is particularly preferable. As a measure of water solubility, it is preferable that the solubility in water at 25 ° C. is 0.5 g / 100 ml or more.

  When the composition of the present invention does not contain the component (D) and the component (A), the concentration of the component (B ′) is preferably a water-soluble or aqueous solution in the range from 1% by weight to a saturated concentration. It is preferable that Water refers to water and alcohols such as methanol, ethanol, propanol and isopropyl alcohol; ketones such as acetone and methyl ethyl ketone; ethers such as tetrahydrofuran; amides such as N, N-dimethylformamide And dimethyl sulfoxide (DMSO). Of these, ethanol, acetone and DMSO are preferably used. Examples of water that can be used here include distilled water, ion-exchanged water, and physiological saline. Here, distilled water and ion-exchanged water are preferably used. In consideration of toxicity and irritation to the living body when used for teeth, it is particularly preferable to use water alone or as a mixed solution of water and ethanol or acetone.

  The calcium compound formed on the tooth by reaction with the component (B ′) or the components (B ′) and (D) is a crystal having various forms, and is generally spherical and relatively round. Shows a round shape, plate shape, needle shape, etc., and its size varies depending on the crystal shape, but it has an average diameter of 0.1 to 10 μm for a spherical or round shape, and an average length of one side for a plate shape. The thickness is 0.1 to 10 μm, and the needle shape is 0.1 to 5 μm in thickness and 1 to 10 μm in length. Such a spherical calcium salt plays a role of sealing the dentinal tubule by a water-insoluble or hardly water-soluble precipitate generated from the component (B ′) on the tooth surface and in the dentinal tubule.

(D) component of this invention is a calcium compound.
The component (D) may not necessarily be used together with the component (B ′), but has an action of promoting the formation of a water-insoluble or hardly water-soluble precipitate of the component (B ′), and the component (D) itself Has the role of blocking the dentinal tubules. Therefore, the component (D) is preferably dissolved or dispersed in water or an aqueous solvent. Furthermore, in order for (D) component itself to block a dentinal tubule, it is preferable that it is a size smaller than a dentinal tubule diameter.
The diameter of the dentinal tubule is usually in the range of 1 to 3 μm, although there are positions, depths, and individual differences.
The diameter of the dentinal tubule is usually determined by scraping the enamel of the extracted tooth and brushing the exposed dentin surface with a dentifrice and a toothbrush for 1 minute or more, and then performing ultrasonic cleaning in water. It can be measured by observing with a scanning electron microscope (SEM).
As the component (D), a water-soluble, water-insoluble, or poorly water-soluble calcium compound can be used. Examples of the water-soluble calcium compound include calcium chloride, calcium hypochlorite, calcium nitrate, calcium hydrosulfide, calcium thiocyanide, calcium thiosulfate, and calcium iodide.

  When only the component (B ′), the water-soluble component (D) and the component (C) are used in the tooth bleach, (B ′) and the component (D) (B) The component ') is preferably in the range of 50 to 99.5 parts by weight, more preferably 60 to 99 parts by weight, and most preferably 80 to 98 parts by weight. Examples of water-insoluble calcium compounds include calcium carbonate, calcium hydroxide, calcium oxide, calcium sulfate, calcium hydrogen phosphate, calcium phosphate, and hydroxyapatite; calcium formate, calcium acetate, calcium oxalate, calcium tartrate, etc. Mention may be made of organic calcium compounds. When only component (B ′), water-insoluble or poorly water-soluble component (D) and component (C) are used, component (B ′) is used in a total of 100 parts by weight of the sum of (B ′) and (D). Is 0.5 to 99.9 parts by weight, preferably 10 to 90 parts by weight, more preferably 20 to 80 parts by weight. A combination of a water-soluble calcium compound and a water-insoluble or poorly water-soluble calcium compound can also be used.

In the tooth bleaching agent, the component (A) is preferably 50 to 99.5 parts by weight, more preferably 70 to 99 parts by weight with respect to 100 parts by weight of the total of the components (B ′) and (D) and (A). Most preferably, it is in the range of 90 to 98 parts by weight. By being in this range, the effect of the present invention remarkably appears.
In the tooth bleaching agent, when all the components (B ′), (D) and (A) are used, the total amount of the components (B ′), (D) and (A) is 100 parts by weight. The component (A) is preferably 50 to 99.9 parts by weight, more preferably 70 to 99.9 parts by weight, and most preferably 80 to 99.9 parts by weight. It is preferable to adjust the sum of the component and the component (D).
Again, the ratio of the component (B ′) and the component (D) can be used at the ratio described above. Moreover, the polymer which is the emulsion particles in the component (A) is 0.1 to 60 parts by weight, preferably 0.5 to 100 parts by weight in total of the components (B ′), (D) and (A). Advantageously, it is in the range of -40 parts by weight, more preferably 1-20 parts by weight.

The persulfuric acid-based bleach used in the component (C) of the present invention is preferably a persulfate salt or a double salt thereof with a sulfate salt. More specifically, a double salt compound of potassium peroxymonosulfate / potassium hydrogensulfate / potassium sulfate, potassium persulfate and sodium persulfate can be used. In some cases, persulfonic acids (RSO ₄ M; R: organic group, M: hydrogen or metal atom) can be used in combination with the persulfuric acid bleach. These persulfuric acid-based bleaching agents are preferably blended in the tooth bleaching agent composition in an amount of 1 to 30% by weight, and more preferably 2 to 10% by weight. If the blending amount is less than 1% by weight, the bleaching effect is diminished. Conversely, if the blending amount exceeds 30%, the stability of the tooth bleaching agent tends to be lowered. Note that the non-peroxide components is too large, such as sulfates, since a bleaching effect persulfate component is less fades, persulfate moiety (SO ₅₎ is preferably in the tooth bleaching composition 0.6 to 22 % By weight, more preferably 1 to 10% by weight.
In addition to the persulfuric acid bleach, hydrogen peroxide or a compound that supplies hydrogen peroxide may be used in combination. The compound that supplies hydrogen peroxide is a peroxide that can generate hydrogen peroxide by reacting easily with water at room temperature, excluding persulfuric acids (depending on conditions, the persulfuric acid may be used). And adduct bodies in which hydrogen peroxide is formed by loose bonds such as hydrogen bonds.

In addition to the above-mentioned persulfate bleaches, percarbonates, perphosphates, peroxides (calcium peroxide, sodium peroxide, magnesium peroxide, etc.), perborates (sodium perborate, etc.) and urea peroxide Etc. are preferably added.
The latent content of hydrogen peroxide by the compound supplying hydrogen peroxide is preferably 0.5 to 10% by weight, more preferably 2 to 5% by weight, based on the composition. If the value falls below the lower limit of the numerical range, the bleaching effect is lowered, and if it exceeds the upper limit, there is a concern about harm to the living body, which is not preferable.

The latent content of hydrogen peroxide is the present composition calculated by the amount of hydrogen peroxide that can be theoretically supplied by a compound that supplies the hydrogen peroxide at a predetermined concentration in a closed system. It is the hydrogen peroxide content.
The content of hydrogen peroxide used in addition to the persulfuric acid-based bleaching agent is preferably 0.1 to 10% by weight, more preferably 1 to 5% by weight, and is used for tooth bleaching. If the value falls below the lower limit of the numerical range, the bleaching effect is lowered, and if it exceeds the upper limit, there is a concern about harm to the living body, which is not preferable.

In addition, if necessary, a pH adjuster for further enhancing the activity of the peroxide and the bleaching effect, a thickener for enhancing the application property to the tooth surface, a colorant for clarifying the application range, the above A stabilizer or the like for improving the storage stability of the compound can be added.
A water-miscible solvent can be added to the above composition so that all the components can be rapidly mixed. Specific examples of the solvent include ethyl alcohol, acetone, glycerin, ethylene glycol, and propylene glycol. Among them, ethyl alcohol, acetone and glycerin are preferable, and ethyl alcohol is particularly preferable.

Further, in the composition of the present invention, when a compound that supplies hydrogen peroxide in an aqueous solution and an aqueous emulsion component or a water-soluble organic acid coexist in a solution state for a long period of time, the reaction proceeds, and thus, when used. If there is a risk of deactivation, it is preferable to store a compound that supplies hydrogen peroxide in an aqueous solution separately from an emulsion component or a water-soluble organic acid.
Moreover, although light irradiation is not necessarily required, light irradiation may be performed.
An aggregation accelerator can be added to the tooth bleaching agent within a concentration range that does not impair the effects of the invention. Specific examples of aggregation promoters include inorganic acids such as hydrochloric acid and nitric acid; chlorides and oxides such as iron, copper, zinc, strontium, silver and tin; formic acid, acetic acid, lactic acid, citric acid, itaconic acid, malein Examples include acids, succinic acid, malic acid, tannic acid, toluenesulfonic acid, adipic acid, tartaric acid, ascorbic acid, organic acids and metal salts thereof; and EDTA. Moreover, fluorides, such as sodium fluoride and potassium fluoride, can be used as needed.

In addition, within a concentration range that does not impair the effects of the invention, inorganic calcium salts such as calcium chloride, calcium hydroxide, calcium hydrogen carbonate, calcium carbonate, calcium oxide, calcium hydrogen phosphate, calcium phosphate, hydroxyapatite, etc. Can be used.
In order to reduce the metal ion concentration of the water-soluble emulsion component used in the present invention, a hydroultrafiltration method and a dialysis method can be used. Of these, the hydrofiltration method is preferred.
The hydroultrafiltration method is used industrially including food products and pharmaceuticals as one of membrane filtration and membrane separation methods. Ultrafiltration devices and membranes are described in Editorial Secretary Hiroshi Shimizu, supervised by Masayuki Nakagaki, “Membrane Processing Technology University” (Fuji Techno System Publishing).

  In the present invention, the apparatus described in the above-mentioned book can be used, and the UF apparatus and the membrane described in “Monthly Food Chemical '90 December issue” written by Katsura Hikasa “Recent application of flat membrane type UF apparatus” are used. You can also More specifically, for example, a PC cassette system made by Rhone-Poulein can be used. Examples of the material for the membrane in the form of a cassette include polyacrylonitrile copolymer, polyvinylidene fluoride, sulfonated polysulfone and polyethersulfone, and sulfonated polysulfone is particularly preferred.

  Examples of water that can be used to reduce the metal ion concentration in the dispersion medium of the emulsion in the tooth bleaching agent include ordinary distilled water, deionized water, and purified water. Furthermore, for example, water called strong oxidation water or strong acid water obtained by electrolysis of water can be used. The concentration of metal ions contained in the water is preferably 100 ppm or less, more preferably 10 ppm or less, and most preferably 1 ppm or less.

  In addition, in the case of tooth bleach, considering the fact that it is a composition used in the oral cavity, water that conforms to the standards of the Japanese Pharmacy Law and water approved as a food additive such as medical, pharmaceutical and food It is preferred to use water that meets the standards.

Ingredient (A) in the tooth bleaching material increases the growth of microorganisms by setting the metal ion concentration in the dispersion medium to 1,000 ppm or less, particularly by reducing the concentration to 1,000 ppm or less by the ultrafiltration method. It was clarified that it can be suppressed and does not grow even if it is mixed with mold. The generation and propagation of such microorganisms such as mold is not preferable because it is not hygienic and the emulsion is easily broken by the generation of malodor and aggregation of emulsion particles.
Preservative components can be used to prevent the generation of microorganisms in the emulsion. Here, the preservative is a concept including an antifungal agent.

  Examples of the preservative that can be used include general preservatives that can be used industrially. However, as a preservative suitable for the purpose of the present invention, it has low toxicity to the human body and is hygienic, and does not impair the hypersensitivity suppression effect without significantly agglomerating the emulsion particles in the short and long term. You should choose one. The cohesiveness of emulsion particles is strongly influenced by the chemical structure and the amount of preservative used. On the other hand, the preservative effect of the preservative is strongly influenced by the components and composition of the polymer constituting the emulsion, the concentration of various dissolved components such as cations and anions in the emulsion, and the pH of the emulsion. Therefore, a combination satisfying the three factors of toxicity / hygiene for human body, non-aggregation of emulsion particles and antiseptic effect is selected.

  Hereinafter, the present invention will be specifically described with reference to examples and the like, but the present invention is not limited to the following examples.

○ Bleaching performance evaluation method The color tone of the human tooth surface was measured using a high-speed spectrophotometer (CMS-35FS / C manufactured by Murakami Color Research Laboratory Co., Ltd.), and bleached for a certain period of time with the adjusted bleach composition. The bleaching performance was evaluated by the change in ΔE accompanying the progress of bleaching by processing.

(Emulsion synthesis example 1)
50 ml of distilled water was heated to 60 ° C., and nitrogen gas was bubbled for 1 hour. Under a nitrogen atmosphere, 2.0 g of methyl methacrylate (MMA), 0.54 g of sodium styrenesulfonate (SSNa), 30 mg of potassium persulfate, and 10 mg of sodium hydrogen sulfite were added, and the mixture was vigorously stirred at 60 ° C. for 2.5 hours. Further, 1.0 g of MMA, 15 mg of potassium persulfate, and 7 mg of sodium hydrogen sulfite were added four times at 30 minute intervals, and the mixture was further vigorously stirred for 19.5 hours. After cooling to room temperature, 0.19 ml of concentrated hydrochloric acid was added and stirred for 2 hours. The mixture was placed in a dialysis tube, and dialysis was repeated while exchanging distilled water every day for 5 days. The tube was dried at room temperature and normal pressure to obtain an emulsion having a solid content of 10.9 wt%. From the elemental analysis, the content of the MMA unit of this polymer was 96.9 mol%. When the obtained polymer was analyzed using GPC with polymethyl methacrylate having a known molecular weight as a standard sample, the number average molecular weight (Mn) was 1.0 × 10 ⁶ . From observation under a transmission microscope, the emulsion polymer emulsion particles are in the range of 0.1 to 0.5 μm in diameter, and all the polymer emulsion particles are measured by a laser diffraction / scattering particle size distribution analyzer (LA-910, Horiba). The diameter was confirmed to be 1 μm or less. Hereinafter, this emulsion is abbreviated as MSE.

  After the emulsion MSE is diluted with distilled water, an equal weight of an aqueous solution in which 1% by weight of calcium chloride as a calcium compound is dissolved is added to the emulsion MSE having a nonvolatile component of 5% by weight, and the particle size distribution measuring apparatus LA is stirred. The particle size was measured in the same manner at -910. The polymer emulsion particles present in the emulsion MSE were agglomerated, and the particle size was distributed over a wide range of 0.1 to 700 μm and had peaks at about 0.3 and about 40 μm. Emulsion MSE was diluted with distilled water to give an emulsion containing 5% by weight of polymer in water.

(Emulsion synthesis example 2)
In the emulsion synthesis example, an emulsion was synthesized by repeating the synthesis example except that a hydroultrafiltration device was used instead of the dialysis tube. Purification was performed up to 5 times as much as the hydrolysis using an ultrafiltration apparatus PC cassette system (manufactured by Rhone-Poulenc) and a sulfonated polysulfone membrane IRIS3026. The membrane area of the ultrafiltration device was 0.506 m ² , and the average operating pressure was 0.5 to 3 kgf / cm ² . Hereinafter, the same ultrafiltration device and filtration membrane were used for the experiment. The emulsion was diluted with distilled water to a non-volatile component concentration of 5% by weight. A part of the sample was taken out, the emulsion particles were filtered with an ultrafiltration device, and the metal ion concentration in the filtrate was measured with a desktop plasma emission spectrometer (SPS7700, manufactured by Seiko Denshi Kogyo Co., Ltd.). The same measuring apparatus was used in the following experiments. The measured metal ions in the dispersion medium were mostly sodium and potassium ions derived from monomers and polymerization initiators, and almost no other metals were detected. As a result, the metal ion concentration (Na + K) was 230 ppm. The emulsion was transferred into a covered plastic container and stored in the dark at room temperature for about 3 months. As a result, no mold was observed. In order to eliminate the influence of microorganisms adhering to the container, the container used for the observation was previously washed with ethanol and dried. Thereafter, the container was washed in the same manner and used for the experiment. Emulsion MSE was diluted with distilled water to give an emulsion containing 5% by weight of polymer in water.

Tooth bleaching test
Example 1
2.0 g of 6% hydrogen peroxide water, 0.20 g of oxone (manufactured by DuPont, KHSO ₄ · K ₂ SO ₄ · 2KHSO ₅ ), 0.004 g of sodium hydrogen carbonate, 0.004 g of sodium carbonate, 380 (Nippon Aerosil Co., Ltd.) )) 0.39 g, emulsion liquid 1.0 g, and 3% oxalic acid aqueous solution 1.0 g were mixed to form a uniform paste, and then uniformly applied to the tooth surface.
One bleaching time was 20 minutes, and the application of a new bleaching agent composition was repeated three times each time. As a result, the brightness ΔL was improved to 7.4 and the color difference ΔE was improved to 11.7, and bleaching was performed. The tooth surface condition was protected by a polymer film.

Example 2
2.0 g of 10% hydrogen peroxide solution and 0.20 g of oxone (manufactured by DuPont, KHSO ₄ · K ₂ SO ₄ · 2KHSO ₅ ), 0.004 g of sodium bicarbonate, 0.004 g of sodium carbonate, 380 (Nippon Aerosil Co., Ltd.) )) 0.39 g, emulsion liquid 1.0 g, and 3% oxalic acid aqueous solution 1.0 g were mixed to form a uniform paste, and then uniformly applied to the tooth surface.
One bleaching time was 20 minutes, and the application of a new bleaching agent composition was repeated three times each time. As a result, the brightness ΔL was improved to 7.5 and the color difference ΔE was improved to 12.0. The tooth surface condition was protected by a polymer film.

Comparative Example 1
Uniform paste by mixing sodium hydrogen carbonate 0.0005g, sodium carbonate 0.0005g, 380S 0.13g, emulsion 0.25g, 3% oxalic acid aqueous solution 0.25g in 6% hydrogen peroxide water 0.6g And then uniformly applied to the teeth.
One bleaching time was 20 minutes, and the application of a new bleaching agent composition was repeated three times each time. As a result, the brightness ΔL was 0.9 and the color difference ΔE was 1.4, which was hardly bleached. The tooth surface condition was protected by a polymer film.

Example 3
2.0 g of 6% hydrogen peroxide water, 0.20 g of oxone (manufactured by DuPont, KHSO ₄ · K ₂ SO ₄ · 2KHSO ₅ ), 0.004 g of sodium hydrogen carbonate, 0.004 g of sodium carbonate, 380 (Nippon Aerosil Co., Ltd.) )) 0.39 g, 2.5 wt% polymer (MSE) and an aqueous solution containing 1 wt% ammonium sulfate simultaneously and 0.5 wt% calcium chloride aqueous solution are stored in separate containers and immediately before use. 1.0 g each was taken out and mixed well to obtain a uniform paste, which was then uniformly applied to the tooth surface.
One bleaching time was 20 minutes, and the application of a new bleaching agent composition was repeated three times each time. As a result, the brightness ΔL was improved to 5.4, the color difference ΔE was improved to 8.5, and bleaching was performed. The tooth surface condition was protected by a polymer film.

Example 4
2.0 g of 10% hydrogen peroxide solution and 0.20 g of oxone (manufactured by DuPont, KHSO ₄ · K ₂ SO ₄ · 2KHSO ₅ ), 0.004 g of sodium bicarbonate, 0.004 g of sodium carbonate, 380 (Nippon Aerosil Co., Ltd.) )) 0.39 g, 2.5 wt% polymer (MSE) and an aqueous solution containing 1 wt% ammonium sulfate simultaneously and 0.5 wt% calcium chloride aqueous solution are stored in separate containers and immediately before use. 1.0 g each was taken out and mixed well to obtain a uniform paste, which was then uniformly applied to the tooth surface.
One bleaching time was 20 minutes, and the application of a new bleaching agent composition was repeated three times each time. As a result, the brightness ΔL was improved to 6.3, the color difference ΔE was improved to 8.6, and bleaching was performed. The tooth surface condition was protected by a polymer film.

Comparative Example 2
To 0.6 g of 6% hydrogen peroxide solution, 0.0005 g of sodium hydrogen carbonate, 0.0005 g of sodium carbonate, 0.13 g of 380S, 2.5% by weight of a high molecular weight polymer (MSE) and 1% by weight of ammonium sulfate were simultaneously added. Store the aqueous solution containing and 0.5% by weight calcium chloride aqueous solution in separate containers, take out 0.25g each before use and mix well,
And then uniformly applied to the teeth.
One bleaching time was 20 minutes, and the application of a new bleaching agent composition was repeated three times each time. As a result, the brightness ΔL was 1.0 and the color difference ΔE was 1.4, which was hardly bleached. The tooth surface condition was protected by a polymer film.

Claims (22)

(AB) water-insoluble, poorly water-soluble or a component capable of forming a Ca salt that becomes aggregated particles in water, and (C) a persulfate bleach.
A bleaching composition for teeth, comprising: (AB) Insoluble in water, hardly soluble in water, or a component capable of forming a Ca salt that becomes aggregated particles in water,
(A) an aqueous emulsion component having an average particle size of less than 3 μm and capable of forming aggregated particles having a particle size of 3 μm or more by reacting with a calcium compound and / or
(B) a water-soluble organic acid component and / or a water-soluble salt component thereof (provided that the calcium salt of the water-soluble organic acid is water-insoluble or poorly water-soluble), and / or
The tooth bleaching composition according to claim 1, which is (B ') a sulfate component. The tooth bleaching composition according to claim 2, wherein the component (AB) is a combination of the component (A) and the component (B). The tooth bleaching composition according to claim 2, wherein the component (AB) is a combination of the component (A) and the component (B '). The component (A) is an emulsion particle comprising a polymer having at least one functional group selected from the group consisting of a carboxyl group, a group in which at least one hydroxyl group is bonded to a phosphorus atom, and a sulfonic acid group. The tooth bleach composition according to any one of claims 2 to 4. The tooth bleaching composition according to any one of claims 2 to 4, wherein the component (A) comprises a copolymer comprising a (meth) acrylic acid alkyl ester component and a styrenesulfonic acid component as emulsion particles. The component (B) is at least one water-soluble oxalic acid compound selected from the group consisting of oxalic acid, metal oxalate, ammonium oxalate and amine oxalate. Tooth bleach composition. The tooth bleaching composition according to any one of claims 1 to 7, wherein the component (C) is a double salt compound of potassium peroxymonosulfate / potassium hydrogensulfate / potassium sulfate, potassium persulfate or sodium persulfate. Claims further containing a compound capable of supplying at least one hydrogen peroxide selected from the group consisting of sodium peroxide, sodium perborate, percarbonate, perphosphate, calcium peroxide, magnesium peroxide and urea peroxide. Item 9. A tooth bleaching composition according to any one of Items 1-8. The tooth bleaching composition according to any one of claims 1 to 9, further comprising at least one selected from the group consisting of a thickener and a pH adjuster. The dental bleaching composition according to claim 9, wherein a latent content of hydrogen peroxide by the compound capable of supplying hydrogen peroxide is 0.5% by weight or more based on the composition. The dental bleaching composition according to claim 9, wherein the latent content of hydrogen peroxide is 2% by weight or more based on the composition. The tooth bleaching composition according to any one of claims 1 to 12, further comprising hydrogen peroxide. The tooth bleach composition according to claim 13, wherein the amount of hydrogen peroxide is 0.1% by weight or more. The tooth bleaching composition according to claim 13, wherein the amount of hydrogen peroxide is 1% by weight or more. The tooth bleaching composition according to any one of claims 1 to 15, further comprising at least one selected from the group consisting of phosphoric acid, condensed phosphoric acid, and salts thereof. (D) The tooth bleaching composition according to any one of claims 1 to 16, further comprising a calcium compound. The tooth bleach composition according to any one of claims 1 to 17, wherein the aqueous emulsion component (A) has a metal ion concentration in a dispersion medium of 1,000 ppm or less. The dental bleaching composition according to claim 2 or 4, wherein the concentration of the component (B ') is in the range of 1% by weight to a saturated concentration and is in the form of an aqueous solution or an aqueous solution. The dental bleaching composition according to claim 17, wherein the component (D) is calcium chloride. The dental bleaching according to claim 17 or 20, wherein the concentration of the component (D) is in the range of 0.01 wt% to a saturated concentration, and is in the form of an aqueous solution or an aqueous solution that may contain an organic solvent. Agent composition. In 100 parts by weight of the dental composition containing the component (A), the polymer in the component (A) is contained in the range of 0.1 to 60 parts by weight in terms of solid matter. The dental composition as described.