JP2007230872A - Skin care preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a skin care preparation that contains octylmethoxycinnamate and alleviates skin irritation of sunscreen cosmetic. <P>SOLUTION: The skin care preparation comprises octylmethoxycinnamate and 6-aminohexanoic acid. The sunscreen cosmetic comprises octylmethoxycinnamate and 6-aminohexanoic acid. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an external preparation for skin having a stimulating effect. More specifically, the present invention relates to a skin external preparation in which 6-aminohexanoic acid is blended with a skin external preparation containing octylmethoxycinnamate to reduce the skin irritation of octylmethoxycinnamate.

  Ultraviolet absorbers are blended in skin external preparations such as sunscreen cosmetics. In many cases, octyl methoxycinnamate is blended in the ultraviolet absorber (Patent Document 1).

On the other hand, octyl methoxycinnamate in sunscreen cosmetics may cause irritation to users of sensitive skin.
Therefore, a method for alleviating the stimulus has been strongly demanded (Patent Documents 2 to 5). For example, Patent Document 2 includes polyethylene glycol, Patent Document 3 includes polypropylene glycol and polybutylene glycol, Patent Document 4 includes polypropylene glycol dimethyl ether, Patent Document 5 includes polyoxyethylene methyl glucoside, A topical skin preparation that relieves the skin irritation of octyl methoxycinnamate by blending polypropylene methyl glucoside is described.

JP-A-7-267842 Japanese Patent Laid-Open No. 2002-212024 JP 2002-284622 A JP 2003-206214 A JP 2004-123543 A

  From the above viewpoint, the present inventor has conducted earnest research on a method for mitigating irritation of octylmethoxycinnamate useful as an ultraviolet absorber in order to obtain a low irritation sunscreen cosmetic. The inventors have found that the cinnamate functions as an effective stimulant-relieving agent and completed the present invention.

  That is, this invention provides the skin external preparation containing an octyl methoxycinnamate and 6-aminohexanoic acid.

  Moreover, this invention provides said skin external preparation whose said skin external preparation is sunscreen cosmetics.

  ADVANTAGE OF THE INVENTION According to this invention, the skin external preparation which relieves the skin irritation of octyl methoxycinnamate can be provided. This is a particularly useful technique for sunscreen cosmetics containing a certain amount of octyl methoxycinnamate.

  The present invention is described in detail below.

  Octylmethoxycinnamate is blended in the external preparation for skin of the present invention as an ultraviolet absorber. Octyl methoxycinnamate has many commercial products, and those commercial products can be used. For example, it is marketed under the trade name of Pulsol MCX (Gibutton Corporation).

The blending amount of octyl methoxycinnamate is appropriately determined according to the target SPF value in the product design of the external preparation for skin. Usually, about 1.0-15 mass% is mix | blended, Preferably it is 2.0-10.0 mass%, More preferably, it is 3.0-8.0 mass%.

6-Aminohexanoic acid used in the present invention is a known compound represented by the following structural formula. In the external preparation for skin of the present invention, 6-aminohexanoic acid is blended as a skin irritation relieving agent for octylmethoxycinnamate.

  The amount of 6-aminohexanoic acid is appropriately determined according to the amount of octyl methoxycinnamate, but is usually about 1.0 to 10% by mass, preferably 3.0 to 5.0% by mass. %.

  The external preparation for skin of the present invention preferably contains titanium oxide and / or zinc oxide powder in addition to the above essential components. Since these function as ultraviolet light scattering agents, they are often blended with octyl methoxycinnamate, especially in sunscreen cosmetics, and these powders are thought to have an effect of enhancing the stimulation of octyl methoxycinnamate. The usefulness of the invention is increased.

  As the titanium oxide and / or zinc oxide powder, a commercially available powder usually blended in cosmetics can be used. As the powder, needle-like, spindle-like, spherical and granular powders are usually used. A fine particle powder having a particle size of 0.1 μm or less is preferred. In addition, silicone treatment such as methylhydrogenpolysiloxane and silane coupling agent; metal soap treatment; fluorine treatment such as perfluoroalkyl phosphate diethanolamine salt and perfluoroalkylsilane, dextrin fatty acid ester treatment, etc. A powder is also preferred.

  The blending amount of the powder is not particularly limited. It is appropriately determined in the range of usually 1.0 to 40% by mass with respect to the total amount of the external preparation for skin. In sunscreen cosmetics, 3.0-25 mass% is preferable with respect to cosmetics whole quantity from a viewpoint of the target SPF value, usability, and stability.

  In the external preparation for skin of the present invention, the above components are blended with the preparation components of the external preparation for skin (for example, oil, water, ethanol, moisturizer, surfactant, thickener, sequestering agent, drug, pigment, and fragrance). However, it is produced by a conventional method according to the target dosage form.

  The dosage form of the external preparation for skin of the present invention is not limited. For example, there are liquid, emulsion, gel, paste, and cream. The external preparation for skin of the present invention is preferably used as a sunscreen cosmetic, but its product form is not limited. Sunscreen cosmetics mean cosmetics that protect the skin from ultraviolet rays.

  The present invention will be specifically described with reference to examples. A compounding quantity is the mass%. Skin irritation was evaluated by the following test.

"Continuous skin irritation test"
Test method:
1. 0.05 ml of the test solution is applied to the back 2 × 2 cm of the guinea pig (first application).
2. After 24 hours, apply a second time.
3. After a further 24 hours, a third application is performed.
Evaluation methods:
Skin reactions such as erythema and edema are observed with the naked eye before the second and third application and 24 hours after the third application. Evaluation is performed according to the following criteria, and the average value of the three scores is used as the skin irritation score.

Evaluation criteria for skin reaction Degree of skin reaction Score No erythema observed 0
Slight erythema is observed 1
Obvious erythema 2
Sick erythema or slight edema, crusts 3
Obvious edema and crusts 4

  The components shown in “Table 1” were mixed to prepare a skin external preparation (sunscreen). The above test was conducted using this external preparation for skin as a test solution to evaluate irritation. In addition, the compounding quantity of octyl methoxycinnamate is 7.5 mass%. In addition, the comparative example 1 is the prescription which does not mix | blend 6-aminohexanoic acid in Example 1, and the comparative examples 2-4 are the prescriptions which replaced with 6-aminohexanoic acid and mix | blended the typical anti-inflammatory agent.

[Table 1]
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Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4
――――――――――――――――――――――――――――――――――――――――
6-Aminohexanoic acid 3.0----
Indomethacin--1.0--
Ibuprofen piconal---5.0-
Piroxicam----0.5
――――――――――――――――――――――――――――――――――――――――
<Common prescription>
Octyl methoxycinnamate 7.5
Titanium dioxide 5.0
Decamethylcyclopentasiloxane 30.0
Organically modified montmorillonite 0.8
1,3-butylene glycol 5.0
Purified water residue ――――――――――――――――――――――――――――――――――――――――
(Manufacturing method) Each component is stirred and mixed to obtain a sunscreen.
――――――――――――――――――――――――――――――――――――――――

  The results are shown in FIG. From this result, the skin irritation of octyl methoxycinnamate was not alleviated even when a typical anti-inflammatory agent was added (Comparative Examples 2 to 4), but when 6-aminohexanoic acid was added, the skin irritation was remarkably reduced. Was recognized. The continuous skin irritation score of FIG. 1 is 0.7 for Example 1, 1.1 for Comparative Example 1, 1.2 for Comparative Examples 2 and 3, and 1.0 for Comparative Example 4.

  Other examples of the present invention will be given below. All of them are external preparations for skin that have an irritation mitigating effect and have an excellent feeling of use.

Example 2 Sunscreen Octylmethoxycinnamate 7.5
6-aminohexanoic acid 3.0
Polypropylene glycol 1000 2.0
t-Butylmethoxydibenzoylmethane 0.1
Titanium dioxide 5.0
Decamethylcyclopentasiloxane 30.0
POE / methylpolysiloxane copolymer 3.0
Organically modified montmorillonite 0.8
1,3-butylene glycol 5.0
Preservative Appropriate amount of perfume Appropriate amount of purified water Remaining (Production method) Stir and mix each component to obtain a sunscreen.

Example 3 Lotion A Octylmethoxycinnamate 1.0
Pentaerythrityl tetraoctanoate 1.0
Polyoxyethylene (20) oleyl alcohol ether
0.5
Ethanol 60.0
Perfume appropriate amount Preservative appropriate amount B sorbit 2.0
Dipropylene glycol 6.0
6-aminohexanoic acid 1.0
Lactic acid 0.1
Citric acid 0.1
Sodium citrate 0.05
Hydroxymethoxybenzophenone Sodium sulfonate appropriate amount Trisodium edetate appropriate amount Purified water The remainder (production method) B is mixed and adjusted. Separately, other components of A are dissolved in ethanol to prepare A, and this is added to B to solubilize, and filtered to obtain a lotion.

Example 4 Sunscreen Emulsification Foundation A Purified Water 52.0
6-aminohexanoic acid 5.0
Ethanol 7.0
B Talc 7.0
Titanium dioxide 10.0
Zinc oxide 2.0
Silica anhydride 2.0
Nylon powder 4.0
Color pigment 2.0
C octyl methoxycinnamate 15.0
Pentaerythrityl tetraoctanoate 4.0
Octamethylcyclotetrasiloxane 10.0
Rosin pentaerythlit ester 1.5
Neopentyl glycol diisooctanoate 5.0
Glycerin triisooctanoate 2.0
Polyoxyethylene-modified dimethylpolysiloxane
1.5
Trimethylsiloxysilicate resin 5.0
(Manufacturing method) After stirring A, B sufficiently mixed and pulverized is added and homomixed. After dissolving C, it is added to this and subjected to a homomixer treatment to obtain a sunscreen emulsified foundation.

Example 5 Latex A Stearic Acid 2.0
Cetyl alcohol 0.5
Liquid paraffin 10.0
Polyoxyethylene (10) oleate
1.0
Sorbitan triolate 1.0
Octyl methoxycinnamate 3.0
6-aminohexanoic acid 0.5
Pentaerythrityl tetraoctanoate 1.5
Isopropyl myristate 2.0
Silica 3.0
Preservative Appropriate amount Fragrance Appropriate amount B Diplene glycol 5.0
DMPPG2000 5.0
Triethanolamine 1.0
Hectorite 1.0
Citric acid 0.2
Ethanol 55.0
Purified water Residue (Preparation) B is adjusted and kept at 70 ° C. The ingredients of A are mixed, heated and melted and kept at 70 ° C. A is added to B and uniformly emulsified with a homomixer and rapidly cooled with stirring to obtain an emulsion.

Example 6 Sunscreen Hair Gel A Carbopol 940 0.6
B Purified water 68.0
C Triethanolamine 0.1
D ethanol 14.0
Octyl methoxycinnamate 7.5
6-Aminohexanoic acid 2.5
Methoxyethyl acrylate / hydroxyethyl acrylate / butyl acrylate copolymer 1.0
Polyethylene glycol 1.0
Dimethicone copolymer 4.0
Methylparaben 0.25
Propylparaben 0.05
Fragrance Appropriate amount (production method) A is stirred and dissolved in B, C is added, and then dispersed in a disperser. D is added to this and stirred to obtain the desired hair gel.

  The external preparation for skin of the present invention is excellent in the skin irritation mitigating effect of octylmethoxycinnamate, and has an excellent feeling of use and a sunscreen effect. Particularly useful in sunscreen cosmetics.

It is a graph which shows a continuous skin irritation test result.

Claims (2)

  An external preparation for skin containing octylmethoxycinnamate and 6-aminohexanoic acid. The skin external preparation according to claim 1, wherein the skin external preparation is a sunscreen cosmetic.

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