JP2007217332A - Skin care composition with storage stability even in high-temperature region - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a means for improving high-temperature preservation stability of a skin care composition comprising a polyhydric alcohol extract from Engelhardtia chrisolepis of the family Juglandaceae, Betula japonica of the family Betulaceae or Opiopogon japonicus of the family Liliaceae. <P>SOLUTION: The skin care composition is prepared by including (1) a plant extract assuming discoloring properties during high-temperature preservation and (2) hydroquinone and/or a derivative thereof. The extract from the Engelhardtia chrisolepis of the family Juglandaceae, Betula japonica of the family Betulaceae or Opiopogon japonicus of the family Liliaceae can be exemplified as the plant extract assuming the discoloring properties during the high-temperature preservation. The polyhydric alcohol extract can be exemplified as the plant extract assuming the discoloring properties during the high-temperature preservation. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin suitable for cosmetics including quasi drugs.

  The walnut family (Engelhardtia chrisolepis), birch family birch (Betura japonica) or the lily family Bakumondou (Opiopogon japonicus) is a plant that is used as a medicinal plant in the western or the east, part or all of which is used. Its medicinal properties are said to be derived from glycosides such as saponins or their aglycones contained in plants. Such plant extracts are also used in the field of topical skin preparations such as cosmetics. For example, dullness improving cosmetics utilizing blood circulation promoting action and whitening action (for example, Patent Document 1, Patent Document) 2), hair growth cosmetics using testosterone-α-reductase inhibitory action (see, for example, Patent Document 3), skin care cosmetics using fibroblast proliferation action (see, for example, Patent Document 4), etc. It can be illustrated as an example of such use. As such a plant extract, a polyhydric alcohol extract such as 1,3-butanediol is often used in the field of such an external preparation for skin, and the aglycone is often used under such extraction conditions. Although the extract contained is obtained, when such an extract is contained in an external preparation for skin such as cosmetics, it seems to be derived from the extract in storage at severe high temperature conditions of 50 to 60 ° C. In some cases, a coloring phenomenon is observed. This tendency is more prominent in the polyhydric alcohol extract than in a water extract or a hydrous alcohol extract. Usually, such a coloring phenomenon is dealt with by adding an antioxidant such as BHA or BHT, or a chelating agent such as EDTA or etidronate. In such a coloring phenomenon, such a component is Not very effective. That is, in the topical skin preparation containing polyhydric alcohol extract of Engelhardtia chrisolepis, Betura japonica or Opiopogon japonicus, a means for improving high-temperature storage stability has been developed. It was desired.

  On the other hand, hydroquinone or its derivatives such as glycosides are known to have an inhibitory action on melanin production in external preparations for skin use, and are used in combination with extracts of herbal medicines such as rosemary and suhakuhi. There are also known techniques for enhancing the effect. (See, for example, Patent Document 5 and Patent Document 6) However, 1) Colorability when stored at high temperature, such as extracts of Engelhardtia chrisolepis, Betura japonica, or Opiopogon japonicus There is no known technique for combining a plant extract exhibiting 2) and hydroquinone and / or derivatives thereof into a topical skin preparation, and with such a combination, high-temperature storage of a preparation that is considered to be derived from a plant extract is known. It has not been known at all that coloring in can be suppressed.

JP 2005-289913 A Japanese Patent Application Laid-Open No. 08-92056 JP 05-255102 A Japanese Patent Laid-Open No. 10-45615 JP 05-139950 A JP 05-85926 A

  The present invention has been made under such circumstances, and is for topical skin use containing a polyhydric alcohol extract of Engelhardtia chrisolepis, Betura japonica, or Opiopogon japonicus. An object of the present invention is to provide means for improving storage stability at high temperatures.

In an external skin preparation containing a polyhydric alcohol extract of Engelhardtia chrisolepis, Betura japonica, or Opiopogon japonicus, we eagerly seek a means to improve high-temperature storage stability. As a result of repeated research efforts, the inventors have found that such an improvement can be achieved by combining hydroquinone and / or its derivative with a skin external preparation, and have completed the invention. That is, the present invention is as follows.
(1) A skin external preparation characterized by comprising 1) a plant extract exhibiting colorability during high-temperature storage, and 2) hydroquinone and / or a derivative thereof.
(2) The plant extract that exhibits colorability during high-temperature storage is an extract of Engelhardtia chrisolepis, Betura japonica or Opiopogon japonicus, The skin external preparation as described in (1).
(3) The skin external preparation according to (1) or (2), wherein the plant extract exhibiting colorability during high-temperature storage is a polyhydric alcohol extract.
(4) The skin external preparation according to any one of (1) to (3), wherein the hydroquinone derivative is a hydroquinone glycoside and / or a salt thereof.
(5) The external preparation for skin according to (4), wherein the glycoside of hydroquinone is a hydroquinone glucoside.
(6) The external preparation for skin according to any one of (1) to (5), wherein the preparation component does not contain an oil or fat having an unsaturated aliphatic group.

  ADVANTAGE OF THE INVENTION According to this invention, high-temperature preservation stability is improved in the skin external preparation containing the polyhydric alcohol extract of Engelhardtia chrisolepis, Betura japonica, or Opiopogon japonicus. Means can be provided.

(1) The plant extract that exhibits colorability during high-temperature storage, which is an essential component of the external preparation for skin of the present invention, the skin external preparation of the present invention contains a plant extract that exhibits colorability during high-temperature storage as an essential component. Features. As such a plant extract, one having a high aglycone content is preferable, and as an extract having a high aglycone content, a polyhydric alcohol extract can be preferably exemplified. As the polyhydric alcohol, for example, 1, 3 -Butanediol, propylene glycol, 1,2-pentanediol, 1,2-hexanediol and the like can be suitably exemplified, and 1,3-butanediol is particularly preferable. This is because the extraction efficiency of the active ingredient is excellent. Further, the plant as the base source is preferably one that is preserved at high temperature and contains a highly colored component. Specifically, walnuts are walnuts (yellow japonicus), and preferred plant parts are leaves, birchs, etc. Examples of birch, preferable plant part, bark and lily family Bakumondo, and preferable plant part include massive roots. Such extraction is performed, for example, by adding 1 to 10 times the amount of a solvent, specifically a polyhydric alcohol, with respect to 1 part by mass of the plant use site. If so, it can be produced by dipping for several hours, cooling and removing insoluble matter by filtration or the like. As the index substance of the plant extract, astilbine is aglycone for koji, betulinic acid is aglycon for birch, and methyl ophiopogononone A to B is an aglycon for bacmond. Can be illustrated. If these indicator substances are plant extracts contained in proper amounts, the effects of the present invention are sufficiently exhibited. The appropriate amount is 1 to 1000 μM for astilbine, more preferably 5 to 100 μM, 0.1 to 10 μM for betulinic acid, more preferably 0.5 to 5 μM, methyl ophiopogononone. In the case of A to B, 0.1 to 100 μM, more preferably 0.5 to 10 μM can be exemplified. A production example is shown below.

<Production Example 1>
100 g of dried leaves of Kouki were chopped, 1 l of 1,3-butanediol was added thereto, and the mixture was heated at 90 ° C. for 4 hours. After heating, the mixture was allowed to cool to room temperature, filtered to remove insoluble matters, and extract 1 was obtained. For extract 1, the content of astilbine was measured by HPLC. The HPLC conditions were an ODS column (4.6 mmφ, 150 mm), the column temperature was 40 ° C., the flow rate was 1 ml / min, the elution solvent was an acetonitrile aqueous solution (5% → 40% gradient), and the detection was performed using an ultraviolet part of 220 nm. . The content of astilbine was 9 μM.

<Production Example 2>
100 g of dried birch bark was chopped, 1 l of 1,3-butanediol was added thereto, and the mixture was heated at 90 ° C. for 4 hours. After heating, the mixture was allowed to cool to room temperature, filtered to remove insoluble matters, and extract 2 was obtained. For extract 2, the content of betulinic acid was measured by HPLC. The HPLC conditions were an ODS column (4.6 mmφ, 150 mm), the column temperature was 40 ° C., the flow rate was 1 ml / min, and the elution solvent was a 15 mM phosphate buffered acetonitrile aqueous solution (pH 7; 10% → 50% grapher) with 10 mM tetrabutylammonium bromide. In the detection, an ultraviolet portion of 220 nm was used for detection. The content of betulinic acid was 4 μM.

<Production Example 3>
100 g of dried dried Bacmond roots were chopped, 1 l of 1,3-butanediol was added thereto, and the mixture was heated at 90 ° C. for 4 hours. After heating, the mixture was allowed to cool to room temperature, filtered to remove insoluble matters, and extract 3 was obtained. For extract 3, the content of methyl ophiopogonanone B was measured by HPLC. The HPLC conditions were an ODS column (4.6 mmφ, 150 mm), the column temperature was 40 ° C., the flow rate was 1 ml / min, the elution solvent was an acetonitrile aqueous solution (10% → 80% gradient), and the detection was performed using an ultraviolet part of 220 nm. . The content of methyl ophiopogonanone B was 6 μM.

(2) Hydroquinone which is an essential component of the skin external preparation of the present invention, and derivatives thereof The skin external preparation of the present invention contains hydroquinone or a derivative thereof as an essential component. Preferred examples of the hydroquinone derivative include glycosides such as glucoside, arabinoside, galactoside, furanoside, riboside and maltoside, and alkyl ethers such as methoxide, ethoxide and propoxide, with glycosides being more preferred. Particularly preferred is glucoside. As the glucoside, there are an α-form and a β-form, and any of them can be used, and these two are particularly preferable because the β-form is a natural type. In the external preparation for skin of the present invention, such components have an action of improving storage stability in a high temperature range in the preparation of the plant extract and preventing coloring during storage. The high temperature range means a practical temperature of 50 to 60 ° C. and a severe condition. In order to express such an action, the hydroquinone or its derivative can use only one kind, or can contain two or more kinds. These can be contained in free form or in the form of a salt. These salts can be used without any particular limitation as long as they are used in skin external preparations, for example, alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as calcium salts and magnesium salts. Preferred examples include organic amine salts such as ammonium salt, triethylamine salt, triethanolamine salt, and monoethanolamine salt, and basic amino acid salts such as lysine salt and alginate. As content required in order to show such an effect, it is 0.01-10 mass% with respect to the skin external preparation whole quantity by the total amount, More preferably, it is 0.1-5 mass%.

(3) The skin external preparation of this invention The skin external preparation of this invention contains the said essential component, It is characterized by the above-mentioned. The external preparation for skin of the present invention can be applied without particular limitation as long as it is externally administered to the skin. For example, cosmetics (including quasi-drugs), external pharmaceutical compositions for skin, skin External miscellaneous goods etc. can be illustrated suitably, and cosmetics are particularly preferred among them. Suitable cosmetics include basic cosmetics such as lotions, emulsions, essences, creams and packs, UV protective cosmetics such as sun care lotions and sun care milk, make-up cosmetics such as under-makeup, control colors and foundations. Can be illustrated. Particularly preferred is a basic cosmetic that can fully exhibit the action of the plant extract.

  The external preparation for skin of the present invention can contain, in addition to such components, optional components that are usually used in external preparations for skin. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oil, wax, oil such as beeswax, canola wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpoly Linear polysiloxanes such as oxane and diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane; amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oils such as modified polysiloxanes such as fluorine-modified polysiloxanes; Anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfates; Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), and amphoteric surfactants such as acylmethyltaurine; sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid ester and alkyl glucoside; polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene Polyhydric alcohols such as recall, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol; sodium pyrrolidonecarboxylate Moisturizing ingredients such as lactic acid and sodium lactate; powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, barium sulfate, etc. whose surface may be treated Body, the surface may be treated, inorganic pigments such as bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide; surface may be treated, mica Pearl agents such as titanium, fish phosphorus foil, bismuth oxychloride; red 202 which may be raked, red Color 228, Red 226, Yellow 4, Blue 404, Yellow 5, Red 505, Red 230, Red 223, Orange 201, Red 213, Yellow 204, Yellow 203, Blue 1 No., green 201, purple 201, red 204, etc .; organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer; para-aminobenzoic acid UV absorbers; anthranils Acid UV absorbers; salicylic acid UV absorbers; cinnamic acid UV absorbers; benzophenone UV absorbers; sugar UV absorbers; 2- (2′-hydroxy-5′-t-octylphenyl) benzo Ultraviolet absorbers such as triazole and 4-methoxy-4′-t-butyldibenzoylmethane; lower grades such as ethanol and isopropanol Alcohols; vitamin A or derivatives thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or derivatives thereof, vitamin B such as vitamin B12, vitamin B15 or derivatives thereof; α-tocopherol, β- Preferred examples include vitamins such as tocopherol, γ-tocopherol, vitamin E acetate and the like, vitamins D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone, and the like; and antibacterial agents such as phenoxyethanol.

  As a preferable form of the external preparation for skin of the present invention, it is possible to exemplify not containing an oil or fat having an unsaturated aliphatic group. Examples of the unsaturated aliphatic group include oleyl group, oleoyl group, linol group, linoloyl group, and the like. This is because such fats and oils are easily oxidized in a high temperature range, and hydroquinone, which is an essential component for suppressing the oxidation, and derivatives thereof work, and the original effect may not be sufficiently exhibited. Moreover, in the effect of this invention, since addition of antioxidants, such as BHA and BHT, and chelating agents, such as EDTA and etidronate, is not required, it is preferable not to contain such a component.

  Hydroquinone, a hydroquinone derivative, which is an essential component of the external preparation for skin of the present invention, has a physiological activity such as a whitening effect by itself. Even in the case where the plant extract is contained in the agent, the effect of the present invention is exhibited. Therefore, even if such essential components other than the object are satisfied, they are within the technical scope of the present invention. Belongs.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it is needless to say that the present invention is not limited to such examples.

  In accordance with the formulation shown below, an essence (cosmetic) that is an external preparation for skin of the present invention was produced. That is, each of the components (a), (b) and (c) was heated to 80 ° C., and (b) was gradually added to (a) while stirring. Thereafter, (c) was added to neutralize and cooled by stirring to obtain Essence 1. A comparative example 1 in which the hydroquinone glucoside (β-form) of this product was replaced with water and a comparative example 2 in which EDTA was substituted were also prepared.

<Test Example 1>
The above Essence 1, Comparative Example 1 and Comparative Example 2 were stored for 10 days at 60 ° C. and 5 ° C., and returned to 20 ° C. over 1 day after the storage was completed, using a Konica Minolta Color Difference Meter CR300 at 60 ° C. The color difference (ΔE) between this sample and the sample at 5 ° C. was measured. The results are shown in Table 2. From this, it can be seen that the external preparation for skin of the present invention is excellent in stability at high temperature storage.

  Extract 1 of Production Example 1 of Essence 1 was changed to Extract 2 of Production Example 2 to produce Essence 2. Similarly, Comparative Example 3 in which the hydroquinone glucoside (β form) of this product was replaced with water and Comparative Example 4 in which EDTA was replaced were also prepared in the same manner. The results of evaluating these in the same manner as in Test Example 1 are shown in Table 3. Similar effects were confirmed.

  Extract 1 of Production Example 1 of Essence 1 was replaced with Extract 3 of Production Example 3 to produce Essence 3. Similarly, Comparative Example 5 in which the hydroquinone glucoside (β form) of this product was replaced with water and Comparative Example 6 in which EDTA was replaced were also prepared in the same manner. The results of evaluating these in the same manner as in Test Example 1 are shown in Table 4. Similar effects were confirmed.

  Essence 4 was produced by changing the hydroquinone glucoside of Essence 1 to hydroquinone. Similarly, Comparative Example 1 in which the hydroquinone was replaced with water and Comparative Example 2 in which EDTA was replaced were also prepared. The results of evaluating these in the same manner as in Test Example 1 are shown in Table 5. Similar effects were confirmed.

  Essence 5 was produced by changing the hydroquinone glucoside of Essence 1 to hydroquinone maltoside. Similarly, Comparative Example 1 in which the hydroquinone maltoside was replaced with water and Comparative Example 2 in which EDTA was replaced were also prepared. The results of evaluating these in the same manner as in Test Example 1 are shown in Table 6. Similar effects were confirmed.

  The present invention can be applied to an external preparation for skin such as cosmetics.

Claims (6)

An external preparation for skin comprising 1) a plant extract exhibiting colorability during high-temperature storage, and 2) hydroquinone and / or a derivative thereof. The plant extract exhibiting colorability when stored at high temperature is an extract of Engelhardtia chrisolepis, Betura japonica, or Opiopogon japonicus. The skin external preparation described in 1. The skin external preparation according to claim 1 or 2, wherein the plant extract exhibiting colorability during high-temperature storage is a polyhydric alcohol extract. The skin external preparation according to any one of claims 1 to 3, wherein the hydroquinone derivative is a hydroquinone glycoside and / or a salt thereof. The skin external preparation according to claim 4, wherein the glycoside of hydroquinone is a hydroquinone glucoside. The skin external preparation according to any one of claims 1 to 5, wherein the preparation component does not contain an oil or fat having an unsaturated aliphatic group.