JP2007195673A - Iontophoresis apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an iontophoresis apparatus capable of sufficiently suppressing the deviation in an ion concentration distribution and an interfacial polarization. <P>SOLUTION: This iontophoresis apparatus 10 is so formed that an operation side electrode structure body 12 has a case 13, a second ion exchange membrane 26 installed in the case 13 so as to partition inside the case 13 and be able to vibrate along its surface direction, and a vibrator 17 for vibrating the second ion exchange membrane 26 in the surface direction. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an iontophoresis device for administering drug ions to a living body.

  There is iontophoresis as one of the methods for allowing a drug to penetrate into a living body through skin or mucous membrane. In iontophoresis, a drug ion is electrically driven by applying a voltage of the same conductivity type as that of the drug ion in the drug solution while the drug solution is in contact with the skin or mucous membrane, via the skin or mucous membrane. It is to be transferred into the living body.

  Also, ion exchange membranes that have the function of selectively passing the same type of conductive ions as the charged ions of the drug ions, and ion exchanges that have the function of selectively passing the ions of the opposite conductivity type to the charged ions of the drug ions. An iontophoresis device is known that is provided with a membrane to efficiently administer drug ions (see, for example, Patent Document 1).

  In such an iontophoresis device, the concentration distribution of drug ions in the drug solution may be biased by energization, or polarization may occur at the interface such as the electrode surface or the skin surface. When an ion exchange membrane is provided, polarization may occur on the surface of the ion exchange membrane. Efficient administration of drug ions may be hindered by such a deviation in drug ion concentration distribution or interfacial polarization.

  In contrast, an iontophoresis system is provided with an ultrasonic transducer such as a ceramic or fluorine compound film inside a case filled with a liquid such as a chemical solution to diffuse the drug or prevent interfacial polarization by ultrasonic vibration. An apparatus is known (see, for example, Patent Document 2).

JP-A-4-297277 JP-A-6-70987

  However, there are cases in which the bias of the ion concentration distribution and the interface polarization cannot be sufficiently suppressed only by the vibration of the ultrasonic vibrator.

  Further, in this iontophoresis device, the vibration becomes smaller as the distance from the ultrasonic transducer becomes smaller, so that even in this respect, the deviation of ion concentration distribution and interface polarization may not be sufficiently suppressed.

  The present invention has been made in view of the above problems, and an object of the present invention is to provide an iontophoresis device capable of sufficiently suppressing the deviation of ion concentration distribution and interface polarization.

  Various exemplary embodiments of the present invention are installed in a case so as to be separated from the case for containing at least one of a chemical solution and an electrolytic solution, and to vibrate along the surface direction. An iontophoresis device is provided that includes the ion exchange membrane and a vibrator for exciting the ion exchange membrane in a plane direction.

  In addition, various exemplary embodiments of the present invention include a case for containing at least one of a chemical solution and an electrolytic solution, an ion exchange membrane installed in the case so as to separate the case, and unevenness in a predetermined direction. A concavo-convex surface having a corrugated cross-section and capable of moving back and forth in a direction in which the concavo-convex continues, and a concavo-convex surface having a corrugated surface in cross-section. 2nd uneven part installed so that it may mesh with the uneven surface of a part, and a vibrator for driving the 1st uneven part in the direction where the unevenness continues, unevenness of the 1st uneven part Provided is an iontophoresis device configured to vibrate the first uneven portion and the second uneven portion by rubbing the surface and the uneven surface of the second uneven portion.

  Thus, by providing the part which vibrates in an apparatus, a vibration propagates not only to an ion exchange membrane but the other member which comprises an interface, and can prevent polarization.

  That is, the above object can be achieved by the following various embodiments.

(1) A case for storing at least one of a chemical solution and an electrolyte, and an ion exchange membrane installed in the case so as to be separated from the case and vibrated along the surface direction And an oscillator for exciting the ion exchange membrane in the surface direction.

(2) In (1), the case has a through hole in the vicinity of the end of the ion exchange membrane, and the ion exchange membrane has a protrusion protruding from the through hole to the outside of the case. And an iontophoresis device engaged with the vibrator.

(3) In (2), the iontophoresis is characterized in that at least one of the chemical solution and the electrolytic solution is held in a case that is held in any of the impregnation and inclusion modes in a carrier having water retention. Lesis device.

(4) In (2) or (3), the case is a first case, the through hole of the first case is shielded from the outside, and the projection of the ion exchange membrane and the vibrator are accommodated. An iontophoresis device comprising two cases.

(5) In any one of (1) to (4), the unevenness is continuous in a predetermined direction, the cross-section has a corrugated uneven surface, and the direction in which the unevenness continues is along the vibration direction of the ion exchange membrane. And has a concavo-convex surface having a corrugated cross section, and the concavo-convex surface meshes with the concavo-convex surface of the first concavo-convex portion. And the second uneven portion connected to the ion exchange membrane, and the uneven surface of the first uneven portion and the uneven surface of the second uneven portion are rubbed, An iontophoresis device characterized in that the first uneven portion and the second uneven portion vibrate and the ion exchange membrane vibrates.

(6) A case for containing at least one of a chemical solution and an electrolytic solution, an ion exchange membrane installed in the case so as to separate the inside of the case, and concavities and convexities in a predetermined direction are continuous, and the cross section is corrugated A first concavo-convex portion having a concavo-convex surface and capable of moving back and forth in a direction in which the concavo-convex continues; A second concavo-convex portion installed; and a vibrator for driving the first concavo-convex portion in a direction in which the concavo-convex portion is continuous, the concavo-convex surface of the first concavo-convex portion and the second concavo-convex portion An iontophoresis device configured to vibrate the first uneven portion and the second uneven portion by rubbing against the uneven surface of the portion.

(7) The iontophoresis device according to (5) or (6), wherein the first uneven portion serves also as the vibrator.

(8) In any one of (1) to (7), a working electrode structure for administering drug ions by iontophoresis is provided, and the working electrode structure includes charged ions of the drug ions and A working electrode connected to the same kind of polarity, a first electrolytic solution holding part arranged on the front surface of the working electrode and holding the first electrolytic solution, and arranged on a front surface of the first electrolytic solution holding part A second ion exchange membrane having a function of selectively passing ions of the second conductivity type opposite to the charged ions of the drug ions, and disposed on the front surface of the second ion exchange membrane, including the drug ions A chemical solution holding unit for holding a chemical solution, and a first ion exchange membrane that is disposed in front of the chemical solution holding unit and has a function of selectively passing ions of the same conductivity type as the charged ions of the drug ions And having The second ion exchange membrane (1) to (7) iontophoresis device characterized in that it corresponds to the ion-exchange membrane according to any one of.

(9) In any one of (1) to (8), a non-working electrode structure serving as a counter electrode when administering drug ions by iontophoresis is provided. A non-working side electrode connected to a polarity opposite to the charged ion of the ion, a second electrolytic solution holding part disposed on the front surface of the non-working side electrode and holding the second electrolytic solution, and the second electrolysis A third ion exchange membrane disposed on the front surface of the liquid holding unit and having a function of selectively passing the first conductivity type ions of the same kind as the charged ions of the drug ions, and disposed on the front surface of the third ion exchange membrane A third electrolyte solution holding part for holding the third electrolyte solution, and a second conductivity type ion opposite to the charged ions of the drug ions, which is disposed on the front surface of the third electrolyte solution holding part. Ion exchange membrane having a function of passing through Becomes a iontophoresis device characterized in that it corresponds to the ion-exchange membrane according to any one of the third ion-exchange membrane (1) to (7).

(10) In (8), the first ion exchange membrane is connected so that the projections and depressions are continuous in a predetermined direction and the cross-section has a corrugated projection and depression and can be moved back and forth in the direction in which the projections and depressions continue. A first concavo-convex portion and a second concavo-convex portion that has a corrugated concavo-convex surface in cross section and is arranged so that the concavo-convex surface meshes with the concavo-convex surface of the first concavo-convex portion, When the uneven surface of the uneven portion and the uneven surface of the second uneven portion are rubbed, the first uneven portion and the second uneven portion vibrate and the first ion exchange membrane also vibrates. An iontophoresis device characterized by that.

(11) In (9), the concave and convex portions are continuous in a predetermined direction, and the cross section has a corrugated concave and convex surface, and is connected to the fourth ion exchange membrane so as to be movable back and forth in the continuous direction. A first concavo-convex portion and a second concavo-convex portion that has a corrugated concavo-convex surface in cross section and is arranged so that the concavo-convex surface meshes with the concavo-convex surface of the first concavo-convex portion, When the uneven surface of the uneven portion and the uneven surface of the second uneven portion are rubbed, the first uneven portion and the second uneven portion vibrate and the fourth ion exchange membrane also vibrates. An iontophoresis device characterized by that.

  In the present application, the term “drug ion” is used to mean an ion generated by ion dissociation of a drug and having a medicinal effect.

  Further, in the present application, the term “front surface” is used to mean a surface on the side directed to an administration subject such as a living body in administration of drug ions.

  In the present invention, the ion exchange membrane in contact with the chemical solution or the electrolytic solution vibrates over the entire surface, so that the concentration distribution of ions and the polarization at the interface are effectively suppressed. In addition, since the uneven surface of the first uneven portion and the uneven surface of the second uneven portion are rubbed, a large vibration capable of sufficiently suppressing the concentration distribution of drug ions and the polarization of the interface can be obtained.

  DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Embodiments of the present invention will be described below in detail with reference to the drawings.

(First embodiment)
As shown in FIGS. 1 to 3, an iontophoresis device 10 according to a first embodiment of the present invention has a working electrode structure 12 for administering drug ions by iontophoresis, and an action. Non-working side electrode structure 14 which becomes a counter electrode when administering drug ions from side electrode structure 12, and power supply device connected to these working side electrode structure 12 and non-working side electrode structure 14 with different polarities 16.

  The iontophoresis device 10 is installed in the case 13 so that the working electrode structure 12 is separated from the cylindrical case 13 and the case 13 and can vibrate along the surface direction. The second ion exchange membrane 26 and the vibrator 17 for exciting the second ion exchange membrane 26 in the surface direction are provided.

  Specifically, the working side electrode structure 12 is disposed on the front side of the working side electrode 22 and the working side electrode 22 connected to the power supply device 16 in the same polarity as the charged ions of the drug ions. And a function of selectively passing ions of the second conductivity type opposite to the charged ions of the drug ions, disposed on the front surface of the first electrolyte solution holding unit. A second ion exchange membrane 26 having a chemical solution holding portion 28 disposed on the front surface of the second ion exchange membrane 26 and holding the electrolyte solution containing the drug ions, and disposed on the front surface of the chemical solution holding portion 28. And a first ion exchange membrane 30 having a function of selectively passing ions of the same conductivity type as the charged ions of the drug ions.

  The working side electrode structure 12 is accommodated in the case 13 on the front side of the base sheet 19, and the first ion exchange membrane 30 at the front end of the front side is attached to the end face of the case 13, It is possible to contact the administration subject.

  On the other hand, the non-working side electrode structure 14 is disposed on the front surface of the non-working side electrode 32 and the non-working side electrode 32 connected to the power supply device 16 in the opposite polarity to the charged ions of the drug ions. A second electrolytic solution holding unit 34 holding the electrolytic solution, and a third ion exchange disposed on the front surface of the second electrolytic solution holding unit 34 and having a function of selectively passing ions of the first conductivity type A membrane 36, a third electrolyte solution holding portion 38 disposed on the front surface of the third ion exchange membrane 36 and holding a third electrolyte solution, and disposed on the front surface of the third electrolyte solution holding portion 38, And a fourth ion exchange membrane 40 having a function of selectively passing ions of the second conductivity type.

  The non-working side electrode structure 14 is also accommodated in the cylindrical case 15 on the front side of the base sheet 19, and the fourth ion exchange membrane 40 at the front end on the front side is attached to the end face of the case 15. It is possible to come into contact with the administration target of drug ions such as.

  The first ion exchange membrane 30 and the fourth ion exchange membrane 40 at the tips of the working side electrode structure 12 and the non-working side electrode structure 14 are configured so that no direct current flows between them when energized. It is provided with a certain gap.

  In addition, a working electrode terminal 22A is provided on the rear surface side of the working electrode 22 in the base sheet 19, and the working electrode terminal 22A passes through a through-hole provided in the base sheet 19 to the working electrode 22. Conducted.

  Similarly, a non-working side electrode terminal 32 </ b> A is provided on the rear surface side of the non-working side electrode 32 in the base sheet 19, and this non-working side electrode terminal 32 </ b> A is also a through hole formed in the non-working side base sheet 19. And is conducted to the non-working side electrode 32.

  As shown in FIG. 4, the case 13 of the working electrode structure 12 has a through hole 13 </ b> A near the end of the second ion exchange membrane 26.

  The second ion exchange membrane 26 is a membrane containing an ion exchange resin into which an ion exchange group having a counter ion of a second conductivity type opposite to the charged ions of the drug ions in the drug solution holding unit 28, which will be described later, is introduced. When the drug ion held in the drug solution holding unit 28 is a cation, it contains an anion exchange resin. Conversely, when the drug ion is an anion, it contains a cation exchange resin. As shown in FIG. 5, the second ion exchange membrane 26 has a substantially circular outer diameter that is slightly smaller than the inner diameter of the case 13, and has a protruding portion 26 </ b> A protruding from the through hole 13 </ b> A of the case 13 to the outside of the case 13. Have. The circumferential width of the protruding portion 26A is smaller than the circumferential width of the through hole 13A of the case 13, so that the second ion exchange membrane 26 can rotate and vibrate in the circumferential direction. The gap in the thickness direction of the through hole 13A is slightly larger than the thickness of the second ion exchange membrane 26. In addition, a through hole 26B that penetrates in the thickness direction is formed in the protruding portion 26A. Since the second ion exchange membrane 26 is a thin film, the projection 26A can be inserted into the through hole 13A of the case 13 and incorporated into the case 13 by bending.

  The vibrator 17 is a film-like member in which a metal thin film is laminated on both surfaces of a piezoelectric film such as polyvinylidene fluoride, for example, and the case 13 extends along the outer periphery of the case 13 as shown in FIG. It is installed outside and is bonded to the first ion exchange membrane 30 at the base end 17A by an adhesive or the like. The vibrator 17 expands and contracts in the surface direction along the outer periphery of the case 13 with a change in the magnitude of the voltage applied to the metal thin films on both sides. In addition, a rod-like connecting member 21 that protrudes in the direction of the protruding portion 26A of the second ion exchange membrane 26 and passes through the through hole 26B is attached in the vicinity of the tip 17B of the vibrator 17. When the vibrator 17 expands and contracts, the forward / backward movement of the tip 17B is transmitted to the second ion exchange membrane 26 via the connecting member 21, so that the second ion exchange membrane 26 rotates and vibrates.

  The working side electrode 22 is a thin film such as carbon and is formed on the front side of the base sheet 19. For example, the working electrode 22 can be formed by applying a conductive paint containing a non-metallic conductive filler such as carbon paste. The working electrode 22 can be formed of a copper plate or a metal thin film. However, since the metal eluted from the working electrode 22 may be transferred to a living body during drug administration, a nonmetal is preferable.

  The first electrolytic solution holding unit 24 is impregnated with an electrolytic solution in a carrier having water retention, such as a fiber sheet such as gauze or filter paper, a polymer gel sheet such as a hydrogel of acrylic resin or a segmented polyurethane gel, or the like. It is made to contain. The electrolytic solution is an electrolyte that is more easily oxidized or reduced than water electrolysis (oxidation at the anode and reduction at the cathode), such as drugs such as ascorbic acid (vitamin C) and sodium ascorbate, lactic acid, oxalic acid, malic acid. It is particularly preferable to contain an organic acid such as succinic acid or fumaric acid and / or a salt thereof, whereby it is possible to suppress the generation of oxygen gas or hydrogen gas, and buffer when dissolved in a solvent. By blending a plurality of types of electrolytes in combination as an electrolytic solution, fluctuations in pH during energization can be suppressed.

  The drug solution holding unit 28 is a drug that dissociates into a cationic or anionic drug ion on a carrier having water retention, such as a fiber sheet such as gauze or filter paper, or a polymer gel sheet such as a hydrogel of acrylic resin or a segmented polyurethane gel. It is constituted by impregnating or containing a solution (including a drug precursor). Examples of drugs that dissociate into cationic drug ions include drugs having a blood circulation promoting effect such as benzyl nicotinate and nonylic acid valinylamide, and drugs having anti-inflammatory and analgesic effects such as glycol salicylate and methyl salicylate. Examples of drugs that dissociate into anionic drug ions include ketoprofen, indomethacin, diclofenac, felbinac, and other drugs having anti-inflammatory and analgesic effects.

  The first ion exchange membrane 30 is a membrane-like body containing an ion exchange resin into which an ion exchange group having the same first conductivity type ions as the counter ions as the drug ions in the drug solution holding unit 28 is introduced. When the drug ion held in the holding part 28 is a cation, it contains a cation exchange resin, and when the drug ion is an anion, it contains an anion exchange resin. The first ion exchange membrane 30 has a substantially circular outer diameter that is substantially equal to the outer diameter of the case 13, and a part of the first ion exchange membrane 30 projects outward in the radial direction from the case 13, thereby constituting a base portion 30 </ b> A that supports the vibrator 17. ing. The vibrator 17 may be directly attached to the case 13. Further, the vibrator 17 may be attached to the case 13 via a member different from the first ion exchange membrane 30. In such a case, the first ion exchange membrane 30 may have a configuration in which a first ion exchange paint containing an ion exchange resin is applied to the chemical solution holding unit 28.

  The cation exchange resin that is the material of the second ion exchange membrane 26 and the first ion exchange membrane 30 is a three-dimensional such as a hydrocarbon resin such as polystyrene resin or acrylic resin, or a fluorine resin having a perfluorocarbon skeleton. An ion exchange resin in which a cation exchange group such as a sulfonic acid group, a carboxylic acid group, or a phosphonic acid group (an exchange group in which the counter ion is a cation) is introduced into a polymer having a simple network structure can be used.

  In addition, as anion exchange resin, a polymer having a three-dimensional network structure similar to the cation exchange resin, a primary to tertiary amino group, a quaternary ammonium group, a pyridyl group, an imidazole group, a quaternary pyridinium group, An ion exchange resin into which an anion exchange group such as a quaternary imidazolium group (an exchange group in which the counter ion is an anion) is introduced can be used.

  The non-working side electrode 32 in the non-working side electrode structure 14 has the same configuration as the working side electrode 22 and is provided on the front side of the base sheet 19 in the non-working side electrode structure 14. The configurations and components of the second electrolyte solution holding unit 34 and the third electrolyte solution holding unit 38 are the same as those of the first electrolyte solution holding unit 24.

  Similar to the first ion exchange membrane 30, the third ion exchange membrane 36 is a membrane-like body containing an ion exchange resin into which an ion exchange group having a first conductivity type ion as a counter ion is introduced. It functions as an ion exchange membrane similar to the exchange membrane 30. The third ion exchange membrane 36 may have a configuration in which a coating containing an ion exchange resin into which an ion exchange group having a first conductivity type ion as a counter ion is introduced is applied on the second electrolyte solution holding unit 34. Good.

  The fourth ion exchange membrane 40 is a membrane-like body containing an ion exchange resin into which ion exchange groups having ions of the second conductivity type as counter ions are introduced in the same manner as the second ion exchange membrane 26. It functions as an ion exchange membrane similar to the exchange membrane 26. The fourth ion exchange membrane 40 may also have a configuration in which a coating containing an ion exchange resin into which an ion exchange group having a second conductivity type ion as a counter ion is introduced is applied on the third electrolyte solution holding unit 38. Good.

  As shown in FIG. 7, the power supply device 16 includes a first DC power supply 16A, a second DC power supply 16B, an oscillation unit 16C, a control unit 16D, and a switch 16E. As the first DC power supply 16A and the second DC power supply 16B, for example, thin batteries disclosed in Japanese Patent Application Laid-Open No. 11-067236, US Patent Publication No. 2004 / 0185667A1, US Pat. No. 6,855,441, and the like are used. be able to. The oscillation unit 16C is configured to convert a DC voltage input from the second DC power supply 16B into an AC voltage and output the AC voltage. The control unit 16D has a timer function for supplying an alternating current at a predetermined timing. The switch 16E is installed on one side of the first DC power supply 16A and the second DC power supply 16B, and connection / disconnection between these and the outside of the power supply device 16 can be connected / disconnected. The iontophoresis device 10 is disconnected from the first DC power supply 16A, the second DC power supply 16B, and the outside of the power supply device 16 by a switch 16E before use. The first DC power source 16A is connected to the working electrode terminal 22A by a conductive portion 44 such as a coating film of a conductive paint, and is connected to the non-working side electrode terminal 32A by a conductive portion 46. The transmitter 16C is connected to the vibrator 17.

  The power supply device 16 includes the first DC power supply 16A and the second DC power supply 16B, but the first DC power supply 16A may also serve as the second DC power supply. The power supply device 16 is configured to supply a direct current and an alternating current. However, a power supply device for supplying a direct current and a power supply device for supplying an alternating current may be provided independently. Good.

  Next, the operation of the iontophoresis device 10 will be described.

  First, the iontophoresis device 10 is applied to a drug ion administration target such as a living body. At this time, the first ion exchange membrane 30 and the fourth ion exchange membrane 40 of the iontophoresis device 10 are set so as to be in contact with the affected area or the vicinity thereof.

  Next, the switch 16E makes the first DC power supply 16A of the power supply device 16 and the working electrode terminal 22A conductive. As a result, a direct current is supplied to the working electrode structure 12 and the non-working electrode structure 14, and the drug ions in the drug solution holding unit 28 are administered to the living body via the first ion exchange membrane 30. The second DC power supply 16B is also connected to the control unit 16D, but the control unit 16D keeps the connection between the second DC power supply 16B and the oscillation unit 16C in a disconnected state.

  By applying a direct current to the working electrode structure 12 and the non-working electrode structure 14 in this way, the concentration distribution of drug ions in the drug solution holding unit 28 and ions in the first electrolyte solution holding unit 24 is biased. Or polarization occurs at the interface such as the surface of the working electrode 22, the surface of the second ion exchange membrane 26, the surface of the first ion exchange membrane 30, the contact surface between the first ion exchange membrane 30 and the living body, etc. Efficient administration of drug ions may be inhibited.

  On the other hand, when the power supply device 16 applies an alternating voltage to the vibrator 17, the second ion exchange membrane 26 is rotationally vibrated along the surface direction on the entire surface. This vibration sufficiently corrects the concentration distribution of drug ions in the chemical solution holding unit 28 and the concentration distribution of ions in the first electrolyte solution holding unit 24. In addition, the interfacial polarization on the surface of the working electrode 22, the surface of the second ion exchange membrane 26, and the surface of the first ion exchange membrane 30 is sufficiently corrected.

  The second ion exchange membrane 26 may be oscillated intermittently in a plurality of times, or may be oscillated only once during the administration. In addition, the concentration distribution of drug ions in the drug solution holding unit 28, the concentration distribution of ions in the first electrolyte solution holding unit 24, and the interfacial polarization may be reduced when the iontophoresis device 10 is stored for a long time after manufacturing. It can occur even before use. Therefore, for example, the second ion exchange membrane 26 may be vibrated only once immediately after the start of administration of drug ions.

  Thus, drug ions can be efficiently administered by correcting the deviation of ion concentration distribution and interfacial polarization.

  The iontophoresis device 10 has a simple structure because the vibrator 17 is installed outside the case 13, and is compact because the second ion exchange membrane 26 vibrates along the surface direction. Contributes to

  Although there is a gap between the through hole 13A of the case 13 and the protrusion 26A of the second ion exchange membrane 26, the first electrolyte solution holding unit 24 and the chemical solution holding unit 28 are impregnated with a carrier having water retention. Since it is held in any of the contained modes, the outflow of the electrolytic solution in the first electrolytic solution holding unit 24 and the chemical solution in the chemical solution holding unit 28 is prevented or suppressed to a level that causes no problem in practical use.

(Second Embodiment)
Next, a second embodiment of the present invention will be described.

  As shown in FIGS. 8 to 12, the second embodiment is different from the first embodiment in that the working electrode structure 12 has an uneven surface with a corrugated cross section in which unevenness continues in a predetermined direction. The first concave and convex portion 50 has a concave and convex surface that has a corrugated cross section and is engaged with the concave and convex surface of the first concave and convex portion 50. Second concavo-convex portion 52, and the concavo-convex surface of the first concavo-convex portion 50 and the concavo-convex surface of the second concavo-convex portion 52 are rubbed, whereby the first concavo-convex portion 50 and the second concavo-convex portion The part 52 is configured to vibrate. Note that the through hole 13 </ b> A is not formed in the case 13. Since the other configuration is the same as that of the first embodiment, the same reference numerals as those in FIGS.

  The first concavo-convex portion 50 is a film-like member in which a metal thin film is laminated on both surfaces of a piezoelectric film such as polyvinylidene fluoride, which is the same as the vibrator 17 of the first embodiment, and the concavo-convex portion is continuous. It is molded into a shape that is long in the direction of The first concavo-convex portion 50 is disposed outside the case 13 along the outer periphery of the case 13, and is bonded to the base portion 30A of the first ion exchange membrane 30 with an adhesive or the like at the base end 50A.

  The first concavo-convex portion 50 is configured to expand and contract in a direction in which the concavo-convex portion continues by changing the magnitude of the voltage applied to the metal thin films on both sides. In other words, the first uneven portion 50 also serves as a vibrator for driving the first uneven portion 50 in the direction in which the unevenness is continuous.

  The second concavo-convex portion 52 is also a long and thin film-like member and is formed in a shape that is long in the direction in which the concavo-convex portion continues. The second uneven portion 52 is coupled to the outer peripheral surface of the case 13 with an adhesive or the like. Note that the second uneven portion 52 does not expand and contract.

  In the second embodiment, as shown in FIGS. 9 and 10, the first uneven portion 50 expands and contracts, and the uneven surface of the first uneven portion 50 and the uneven surface of the second uneven portion 52 rub against each other. As a result, a sufficiently large vibration capable of suppressing the deviation of the concentration distribution of drug ions in the drug solution holding unit 28, the deviation of the concentration distribution of ions in the first electrolyte solution holding unit 24, and the interfacial polarization can be obtained at high frequency. In particular, vibration propagates efficiently to the first ion exchange membrane 30 connected to the first uneven portion 50. Therefore, drug ions can be administered efficiently. Even when the frequency response of the vibrator (first uneven portion 50) with respect to the drive voltage is dull, the uneven surface of the first uneven portion 50 and the uneven surface of the second uneven portion 52 rub against each other to increase the frequency. Vibration is obtained.

  Further, by appropriately designing the shapes of the uneven surface of the first uneven portion 50 and the uneven surface of the second uneven portion 52, it is possible to adjust the frequency and amplitude of vibration.

  Further, since the first concavo-convex portion 50 also serves as a vibrator for driving itself in a direction in which the concavo-convex portion continues, the structure is simple and compact.

  Since the through hole 13A is not formed in the case 13, the electrolytic solution in the first electrolytic solution holding unit 24 and the chemical solution in the chemical solution holding unit 28 do not flow out of the case 13. Therefore, the 1st electrolyte solution holding part 24 is good also as a structure which hold | maintains electrolyte solution in a liquid state. Further, the first electrolyte solution holding unit 24 may have a configuration in which a paint containing such an electrolyte solution is applied to the working electrode 22. In this case, the electrolyte coating is blended with a hydrophilic polymer such as polyvinyl alcohol, polyacrylic acid, polyacrylamide, or polyethylene glycol in order to improve the coating property and film forming property as a coating, and the viscosity of the electrolyte coating An appropriate amount of a solvent such as water, ethanol, or propanol is added. Furthermore, appropriate additional components such as thickeners, thixotropic agents, antifoaming agents, pigments, fragrances, and coloring agents can be blended. Similarly, the chemical solution holding unit 28 may be configured to hold the drug in a liquid state. Alternatively, the second ion exchange membrane 26 may be coated with a paint containing a drug.

(Third embodiment)
Next, a third embodiment of the present invention will be described.

  As shown in FIGS. 13 to 16, the third embodiment is different from the first embodiment in that the working electrode structure 12 has a concavo-convex surface with a corrugated cross section in which the concavo-convex is continuous in a predetermined direction. The second embodiment is provided so that the direction in which the irregularities are continuous follows the vibration direction of the second ion exchange membrane 26 and can move forward and backward in the vibration direction of the second ion exchange membrane 26. A similar first concavo-convex portion 50 and a concavo-convex surface having a corrugated cross section are installed outside the case 13 so that the concavo-convex surface meshes with the concavo-convex surface of the first concavo-convex portion 50, and the second ion exchange The first concavo-convex portion 60 connected to the film 26, and the concavo-convex surface of the first concavo-convex portion 50 and the concavo-convex surface of the second concavo-convex portion 60 rub against each other. And the second uneven portion 60 vibrates and the second ion exchange membrane 26 vibrates. It is characterized in that it was. Since the other configuration is the same as that of the first embodiment, the same reference numerals as those in FIGS. Since the first uneven portion 50 is the same as that described in the second embodiment, description of the first uneven portion 50 is also omitted.

  The second concavo-convex portion 60 is a part of the second ion exchange membrane 26 formed into a concavo-convex shape, and is integrally connected to the second concavo-convex portion 60, and from the through hole 13 A of the case 13 to the case 13. Projects outward.

  In the third embodiment, when the first concavo-convex portion 50 expands and contracts, the concavo-convex surface of the first concavo-convex portion 50 and the concavo-convex surface of the second concavo-convex portion 60 rub against each other to generate vibration and the second. The ion exchange membrane 26 also rotates and vibrates on the entire surface along the surface direction. More specifically, high-frequency vibration is generated by rubbing the uneven surface of the first uneven portion 50 and the uneven surface of the second uneven portion 60, and this vibration causes the second ion exchange membrane 26 to move in the thickness direction. And the second ion exchange membrane 26 also oscillates in the plane direction. In addition, vibration is efficiently transmitted to the first ion exchange membrane 30 connected to the first uneven portion 50. Even when the frequency response of the vibrator (first uneven portion 50) with respect to the drive voltage is dull, the uneven surface of the first uneven portion 50 and the uneven surface of the second uneven portion 52 rub against each other to increase the frequency. Vibration is obtained. Due to the synergistic effect of these vibrations, the deviation of the concentration distribution of drug ions in the drug solution holding unit 28 and the deviation of the concentration distribution of ions in the first electrolyte solution holding unit 24 are remarkably corrected. In addition, the interfacial polarization on the surface of the working electrode 22, the surface of the second ion exchange membrane 26, and the surface of the first ion exchange membrane 30 is remarkably corrected. Therefore, drug ions can be administered efficiently.

  Further, by appropriately designing the shape of the uneven surface of the first uneven portion 50 and the uneven surface of the second uneven portion 60, the frequency and amplitude of vibration can be adjusted.

  Further, the first concavo-convex portion 50 also serves as a vibrator for driving the first concavo-convex portion 50 in the direction in which the concavo-convex continues, and the second ion exchange membrane 26 vibrates along the surface direction. This contributes to downsizing. In addition, since the first concavo-convex portion 50 also serving as a vibrator is installed outside the case 13, the structure is simple.

  Although there is a gap between the through hole 13A of the case 13 and the second concavo-convex portion 60, the first electrolyte solution holding unit 24 and the chemical solution holding unit 28 are either impregnated or contained in a carrier having water retention. Therefore, the outflow of the electrolytic solution in the first electrolytic solution holding unit 24 and the chemical solution in the chemical solution holding unit 28 is prevented or suppressed to a level that causes no problem in practical use.

(Fourth embodiment)
Next, a fourth embodiment of the present invention will be described.

  As shown in FIGS. 17 to 20, the fourth embodiment is different from the third embodiment in that the first uneven portion 50 and the second uneven portion 60 are different from the first uneven portion 50. It is characterized in that it is connected by the same connecting member 21 as in the first embodiment, which is coupled in the vicinity of the tip and penetrates the through hole 26B in the vicinity of the tip of the second uneven portion 60. Since other configurations are the same as those of the third embodiment, the same reference numerals as those in FIGS.

  In the fourth embodiment example, similarly to the third embodiment example, when the first uneven portion 50 expands and contracts, the uneven surface of the first uneven portion 50 and the uneven surface of the second uneven portion 60 are changed. By rubbing, high-frequency vibration is generated. This vibration causes the second ion exchange membrane 26 to vibrate in the thickness direction, and the second ion exchange membrane 26 also rotationally vibrates in the surface direction. In addition, vibration is efficiently transmitted to the first ion exchange membrane 30 connected to the first uneven portion 50. Even when the frequency response of the vibrator (first uneven portion 50) with respect to the drive voltage is dull, the uneven surface of the first uneven portion 50 and the uneven surface of the second uneven portion 60 rub against each other to increase the frequency. Vibration is obtained. Due to the synergistic effect of these vibrations, the deviation of the concentration distribution of drug ions in the drug solution holding unit 28 and the deviation of the concentration distribution of ions in the first electrolyte solution holding unit 24 are remarkably corrected. In addition, the interfacial polarization on the surface of the working electrode 22, the surface of the second ion exchange membrane 26, and the surface of the first ion exchange membrane 30 is remarkably corrected. Therefore, drug ions can be administered efficiently.

  In addition, since the 1st uneven | corrugated | grooved part 50 and the 2nd uneven | corrugated | grooved part 60 are connected by the connection member 21 in the vicinity of the front-end | tip, even if the 1st uneven | corrugated part 50 expands and contracts, the relative part of the vicinity of both front-end | tip However, since the relative positional relationship between the concave and convex portions of the two changes, the concave and convex surfaces of the first concave and convex portions 50 and the concave and convex surfaces of the second concave and convex portions 60 rub against each other, and high-frequency vibrations are generated. appear.

(Fifth embodiment)
Next, a fifth embodiment of the present invention will be described.

  As shown in FIG. 21, in the fifth embodiment, in contrast to the first embodiment, the non-working side electrode structure 14 is also installed so as to separate the inside of the case 15 of the non-working side electrode structure 14. The formed third ion exchange membrane 36 is held in the case 15 so as to be able to vibrate along its surface direction, and the vibrator 17 capable of exciting the third ion exchange membrane 36 in the surface direction is provided in the case 15. It is characterized by being installed outside. The third ion exchange membrane 36 is provided with a protrusion 36A. Since the other configuration is the same as that of the first embodiment, the same reference numerals as those in FIGS.

  The third ion exchange membrane 36 of the non-working side electrode structure 14 vibrates along the surface direction over the entire surface, so that the second electrolytic solution holding unit 34 and the third electrolytic solution holding are also performed in the non-working side electrode structure 14. The deviation of the ion concentration distribution in the portion 36 is corrected. In addition, interface polarization on the surface of the non-working side electrode 32, the surface of the third ion exchange membrane 36, and the surface of the fourth ion exchange membrane 40 is also corrected. Therefore, drug ions can be administered more efficiently.

(Sixth embodiment)
Next, a sixth embodiment of the present invention will be described.

  As shown in FIG. 22, the sixth embodiment is different from the second embodiment in that the non-working side electrode structure 14 also has an uneven surface with a corrugated cross section and is installed outside the case 15. The first concavo-convex portion 50 has a corrugated concavo-convex surface in cross section, and the concavo-convex surface meshes with the concavo-convex surface of the first concavo-convex portion 50 and can vibrate in the direction in which the concavo-convex continues. 2nd concavo-convex part 52 installed on the outside of the case 15, and the concavo-convex surface of the first concavo-convex part 50 and the concavo-convex surface of the second concavo-convex part 52 rub against each other, The portion 50 and the second uneven portion 52 are configured to vibrate. Since the other configuration is the same as that of the second embodiment, the same reference numerals as those in FIGS.

  As described above, since the non-working side electrode structure 14 is also provided with the first concavo-convex part 50 and the second concavo-convex part 52, a large high-frequency vibration can be obtained in the non-working side electrode structure 14. The deviation of the ion concentration distribution in the liquid holding unit 34 and the third electrolyte holding unit 36 is sufficiently corrected. In particular, vibration is efficiently propagated to the fourth ion exchange membrane 40 connected to the first uneven portion 50. In addition, the interfacial polarization on the surface of the non-working side electrode 32, the surface of the third ion exchange membrane 36, and the surface of the fourth ion exchange membrane 40 is sufficiently corrected. Therefore, drug ions can be administered more efficiently.

(Seventh embodiment)
Next, a seventh embodiment of the present invention will be described.

  As shown in FIG. 23, the seventh embodiment is different from the third embodiment in that the non-working side electrode structure 14 also has an uneven surface with a corrugated cross section in the direction in which the unevenness continues. 3 The first concavo-convex portion 50 provided on the outer side of the case 15 along the vibration direction of the ion exchange membrane 36 and provided on the case 15 side, and a concavo-convex surface having a corrugated cross section. A second concavo-convex portion 60 provided outside the case 15 so as to mesh with the concavo-convex surface of the first concavo-convex portion 50 and provided on the third ion exchange membrane 36 side. The uneven surface of the portion 50 and the uneven surface of the second uneven portion 60 are rubbed so that the first uneven portion 50 and the second uneven portion 60 vibrate and the third ion exchange membrane 36 vibrates. It is characterized by being composed. Since other configurations are the same as those of the third embodiment, the same reference numerals as those in FIGS.

  Thus, the non-working side electrode structure 14 is also provided with the 1st uneven part 50 and the 2nd uneven part 60, and when the 1st uneven part 50 expands and contracts, the unevenness | corrugation of the 1st uneven part 50 is obtained. The surface and the concavo-convex surface of the second concavo-convex portion 60 rub against each other to generate high-frequency vibration, which causes the third ion exchange membrane 36 to vibrate in the thickness direction and the third ion exchange membrane 36 to move in the surface direction. Also oscillates. In addition, vibration is efficiently propagated to the fourth ion exchange membrane 40 connected to the first uneven portion 50. Due to the synergistic effect of these vibrations, the deviation of the ion concentration distribution in the second electrolyte solution holding part 34 and the third electrolyte solution holding part 38 is remarkably corrected. In addition, the interfacial polarization on the surface of the non-working side electrode 32, the surface of the third ion exchange membrane 36, and the surface of the fourth ion exchange membrane 40 is remarkably corrected. Therefore, drug ions can be administered more efficiently.

(Eighth embodiment)
Next, an eighth embodiment of the present invention will be described.

  As shown in FIG. 24, the eighth embodiment is different from the fourth embodiment in that the non-working side electrode structure 14 also has an uneven surface with a corrugated cross section in the direction in which the unevenness continues. 3 The first concavo-convex portion 50 provided on the outer side of the case 15 along the vibration direction of the ion exchange membrane 36 and provided on the case 15 side, and a concavo-convex surface having a corrugated cross section. A second concavo-convex portion 60 provided outside the case 15 so as to mesh with the concavo-convex surface of the first concavo-convex portion 50 and provided on the third ion exchange membrane 36 side, and these are in the vicinity of the tip In this case, the first uneven portion 50 and the second uneven portion 60 vibrate when the uneven surface of the first uneven portion 50 and the uneven surface of the second uneven portion 60 are rubbed. And the third ion exchange membrane 36 is configured to vibrate. To have. Since the other configuration is the same as that of the fourth embodiment, the same reference numerals as those in FIGS.

  Similarly to the seventh embodiment, the eighth embodiment is also provided with the first concavo-convex portion 50 and the second concavo-convex portion 60 in the non-working side electrode structure 14 so that the first concavo-convex portion 50 is provided. The uneven surface of the second surface and the uneven surface of the second uneven portion 60 rub against each other to generate a high-frequency vibration. This vibration causes the third ion exchange membrane 36 to vibrate in the thickness direction, and the third ion exchange membrane 36 has a surface. Also vibrates in the direction. In addition, vibration is efficiently propagated to the fourth ion exchange membrane 40 connected to the first uneven portion 50. Due to the synergistic effect of these vibrations, the deviation of the ion concentration distribution in the second electrolyte solution holding part 34 and the third electrolyte solution holding part 38 is remarkably corrected. In addition, the interfacial polarization on the surface of the non-working side electrode 32, the surface of the third ion exchange membrane 36, and the surface of the fourth ion exchange membrane 40 is remarkably corrected. Therefore, drug ions can be administered more efficiently.

(Ninth embodiment)
Next, a ninth embodiment of the present invention will be described.

  As shown in FIG. 25, the ninth embodiment is different from the first embodiment in that the case 70 of the working electrode structure 12 has a rectangular tube shape with a substantially rectangular cross section. The exchange membrane 72 is configured to vibrate by reciprocating linear motion. Since the other configuration is the same as that of the first embodiment, the same reference numerals as those in FIGS.

  The second ion exchange membrane 72 is substantially rectangular and has a side length in the vibration direction that is shorter than the length of the inner peripheral side of the case 70, so that it can vibrate along the surface direction.

  Similarly to the first embodiment, in the ninth embodiment, the second ion exchange membrane 26 vibrates on the entire surface along the surface direction, thereby causing the concentration distribution of drug ions in the drug solution holding unit 28 to be biased. The deviation of the concentration distribution of ions in the one electrolyte solution holding unit 24 is corrected. In addition, interfacial polarization on the surface of the working electrode 22, the surface of the second ion exchange membrane 26, and the surface of the first ion exchange membrane 30 is also corrected.

  Similarly, the second to eighth embodiments may be configured to include a rectangular tube case having a substantially rectangular cross section and a substantially rectangular ion exchange membrane. In the fifth to eighth embodiments, both the working electrode structure 12 and the non-working electrode structure 14 may include a rectangular tube case having a substantially rectangular cross section and a substantially rectangular ion exchange membrane. Only one of them may include a rectangular tube-shaped case having a substantially rectangular cross section and a substantially rectangular ion exchange membrane.

(Tenth embodiment)
Next, a tenth embodiment of the present invention will be described.

  As shown in FIG. 26, the tenth embodiment is different from the first embodiment in that the working electrode structure 12 has a case 13 as a first case, and the first case 13 penetrates. The hole 13A is shielded from the outside, and includes a second case 80 that accommodates the vibrator 17 and the protruding portion 26A of the second ion exchange membrane 26. Since the other configuration is the same as that of the first embodiment, the same reference numerals as those in FIGS.

  Thus, by providing the second case 80, the vibrator 17 and the protruding portion 26 </ b> A of the second ion exchange membrane 26 can be protected.

  In addition, even if the electrolytic solution in the first electrolytic solution holding unit 24 or the chemical solution in the chemical solution holding unit 28 flows out of the first case 13, the second case 80 is provided as described above. It is possible to reliably prevent leakage to the outside.

  In addition, it is good also as a structure provided with the 2nd case 80 similarly in the said 3rd-5th embodiment example, 7th, and 8th embodiment example. In the fifth embodiment example, the seventh and eighth embodiment examples, the second case 80 may be provided in both the working side electrode structure 12 and the non-working side electrode structure 14, and only one of them may be provided. A second case 80 may be provided.

  In the first to tenth embodiments, a film-like member in which a metal thin film is laminated on both surfaces of a piezoelectric film such as polyvinylidene fluoride is exemplified as a material of the vibrator 17. For example, another piezoelectric material such as a thin film ceramic may be used.

  In the second, third, fourth, sixth, seventh, and eighth embodiments, the first uneven portion 50 also serves as a vibrator. A vibrator for driving the uneven portion 50 in a direction along the uneven surface may be provided.

  Even when the frequency response of the vibrator with respect to the drive voltage is dull, high-frequency vibration can be obtained by rubbing the uneven surface of the first uneven portion 50 and the uneven surface of the second uneven portion 52.

  In the first to tenth embodiments, the iontophoresis device 10 includes the power supply device 16, but the iontophoresis device does not include the power supply device. Drug ions may be administered by connecting an external power source to the device.

The top view which shows schematic structure of the iontophoresis apparatus which concerns on the 1st Example of this invention. Side view Sectional drawing which expands and shows the structure of the working side electrode and non-working side electrode of the iontophoresis device Enlarged arrow view from IV in Fig. 3 Sectional drawing which follows the VV line in FIG. Sectional view along the VI-VI line in FIG. The block diagram which shows typically the structure of the power supply device of the iontophoresis device Sectional drawing which shows the structure of the iontophoresis apparatus based on 2nd Example of this invention. Side view showing enlarged structure of uneven part of the iontophoresis device Side view showing enlarged operation of the uneven part Sectional drawing which follows the XI-XI line in FIG. Sectional view along line XII-XII in FIG. Sectional drawing which shows the structure of the iontophoresis apparatus which concerns on 3rd Example of this invention. Enlarged view from XIV in Fig. 13 Sectional drawing which follows the XV-XV line in FIG. Sectional drawing which follows the XVI-XVI line in FIG. Sectional drawing which shows the structure of the iontophoresis apparatus based on 4th Embodiment of this invention. 17 is an enlarged view as seen from XVIII in FIG. Sectional view along line XIX in FIG. Sectional view along line XX in FIG. Sectional drawing which shows the structure of the iontophoresis apparatus which concerns on 5th Example of this invention. Sectional drawing which shows the structure of the iontophoresis apparatus based on 6th Embodiment of this invention. Sectional drawing which shows the structure of the iontophoresis apparatus based on 7th Embodiment of this invention Sectional drawing which shows the structure of the iontophoresis apparatus which concerns on the example of 8th Embodiment of this invention. Sectional drawing which shows the structure of the iontophoresis apparatus based on 9th Embodiment of this invention Sectional drawing which shows the structure of the iontophoresis apparatus based on 10th Embodiment of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 ... Iontophoresis apparatus 12 ... Working side electrode structure 13, 15, 70 ... Case 13A ... Through-hole 14 ... Non-working side electrode structure 16 ... Power supply device 17 ... Vibrator 22 ... Working side electrode 24 ... 1st Electrolyte holding part 26, 72 ... 2nd ion exchange membrane 26A, 36A ... Projection part 28 ... Chemical solution holding part 30 ... 1st ion exchange membrane 32 ... Non-action side electrode 34 ... 2nd electrolyte solution holding part 36 ... 3rd ion Exchange membrane 38 ... third electrolyte holding part 40 ... fourth ion exchange membrane 50 ... first uneven part 52, 60 ... second uneven part 80 ... second case

Claims (11)

  A case for containing at least one of a chemical solution and an electrolytic solution, an ion exchange membrane installed in the case so as to be separated from the inside of the case and vibrated along a surface direction thereof, An iontophoresis device comprising: a vibrator for exciting the ion exchange membrane in the plane direction. In claim 1,
The case has a through hole in the vicinity of the end of the ion exchange membrane, and the ion exchange membrane has a protrusion protruding from the through hole to the outside of the case, and the protrusion is engaged with the vibrator. An iontophoresis device characterized by that. In claim 2,
An iontophoresis device, wherein at least one of the chemical solution and the electrolytic solution is held in a case that is impregnated and contained in a carrier having water retention property and contained in the case. In claim 2 or 3,
An iontophoresis device comprising: a first case, wherein the case is a first case, and the through hole of the first case is shielded from the outside, and a second case that accommodates the protrusion of the vibrator and the ion exchange membrane is provided. Lesis device. In any one of Claims 1 thru | or 4,
Concavities and convexities continue in a predetermined direction, and the cross-section has a corrugated uneven surface. The first concavo-convex portion that is movable and the concavo-convex surface having a corrugated cross section are installed so that the concavo-convex surface meshes with the concavo-convex surface of the first concavo-convex portion, and connected to the ion exchange membrane. A second uneven portion, and the first uneven portion and the second uneven portion vibrate when the uneven surface of the first uneven portion and the uneven surface of the second uneven portion rub against each other. And an iontophoresis device characterized in that the ion exchange membrane vibrates.   A case for containing at least one of a chemical solution and an electrolyte, an ion exchange membrane installed in the case so as to separate the inside of the case, and an uneven surface having a corrugated cross section that is continuous in a predetermined direction. A first concavo-convex portion that is capable of moving back and forth in a direction in which the concavo-convex is continuous, and a concavo-convex surface having a corrugated cross section, and the concavo-convex surface is arranged to mesh with the concavo-convex surface of the first concavo-convex portion A second concavo-convex portion; and a vibrator for driving the first concavo-convex portion in a direction in which the concavo-convex portion continues, the concavo-convex surface of the first concavo-convex portion and the concavo-convex portion of the second concavo-convex portion. An iontophoresis device configured to vibrate the first uneven portion and the second uneven portion by rubbing with a surface. In claim 5 or 6,
The iontophoresis device, wherein the first uneven portion serves also as the vibrator. In any one of Claims 1 thru | or 7,
A working electrode structure for administering drug ions by iontophoresis,
The working electrode structure is
A working electrode connected to the same polarity as the charged ions of the drug ions;
A first electrolytic solution holding unit disposed on the front surface of the working electrode and holding the first electrolytic solution;
A second ion exchange membrane disposed on the front surface of the first electrolyte solution holding unit and having a function of selectively passing ions of a second conductivity type opposite to the charged ions of the drug ions;
A chemical solution holding unit disposed on the front surface of the second ion exchange membrane and holding a chemical solution containing the drug ions;
A first ion exchange membrane disposed on the front surface of the drug solution holding part and having a function of selectively allowing the first conductivity type ions of the same kind as the charged ions of the drug ions to pass through;
Having
An iontophoresis device, wherein the second ion exchange membrane corresponds to the ion exchange membrane according to any one of claims 1 to 7. In any one of Claims 1 thru | or 8.
A non-working side electrode structure that serves as a counter electrode when administering drug ions by iontophoresis,
The non-working side electrode structure is
A non-working side electrode connected to a polarity opposite to the charged ion of the drug ion;
A second electrolyte solution holding unit disposed on the front surface of the non-working side electrode and holding the second electrolyte solution;
A third ion exchange membrane disposed on the front surface of the second electrolyte solution holding unit and having a function of selectively passing the same type of first conductivity type ions as the charged ions of the drug ions;
A third electrolyte solution holding unit disposed on the front surface of the third ion exchange membrane and holding the third electrolyte solution;
A fourth ion exchange membrane disposed on the front surface of the third electrolyte solution holding unit and having a function of selectively passing ions of the second conductivity type opposite to the charged ions of the drug ions;
Having
The iontophoresis device, wherein the third ion exchange membrane corresponds to the ion exchange membrane according to any one of claims 1 to 7. In claim 8,
A first uneven portion connected to the first ion-exchange membrane so that the unevenness is continuous in a predetermined direction, the cross-section has a corrugated uneven surface, and is movable back and forth in the direction in which the unevenness continues; Having a corrugated uneven surface, and the uneven surface disposed so as to mesh with the uneven surface of the first uneven portion, the uneven surface of the first uneven portion and the first The first and second concavo-convex parts vibrate and the first ion exchange membrane vibrates by rubbing against the concavo-convex surface of the two concavo-convex parts. Lesis device. In claim 9,
A first uneven portion connected to the fourth ion exchange membrane so that the unevenness is continuous in a predetermined direction, the cross-section has a corrugated uneven surface, and the forward and backward movement is possible in the direction in which the unevenness is continued; Having a corrugated uneven surface, and the uneven surface disposed so as to mesh with the uneven surface of the first uneven portion, the uneven surface of the first uneven portion and the first The iontophoresis is characterized in that the first and second uneven portions vibrate and the fourth ion exchange membrane vibrates by rubbing against the uneven surface of the two uneven portions. Lesis device.

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