JP2007187446A - Automated analyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an analyzer which automizes an operation for the measurement of calibration and reduces user's work and a working error. <P>SOLUTION: The analyzer includes a memory means, which preliminarily stores whether refined water used in the analyzer is used as a standard sample of a zero concentration is used at every analyzing item or the prepared standard sample set to a sample placing position is used, and the function of measuring the control of precision or calibration on the basis of the data stored in the memory means using refined water or the prepared standard sample when the measurement of the control of precision related to an analyzing item or the execution of calibration is directed. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an automatic analyzer that converts a measurement value of a photometer into a concentration using a calibration curve and obtains an analysis result, and particularly has a function of periodically managing the accuracy of a calibration curve using a quality control sample. Relates to an automatic analyzer.

  An automated analyzer that performs qualitative and quantitative analysis of target components in a sample by mixing and reacting the sample and reacting to detect changes in the sample color as absorbance changes using a photometer. Compared to the method of calculating the results, the speed of measurement and the reproducibility of the measurement results are excellent, so that the spread is mainly in large hospitals and inspection centers.

  In the automatic analyzer, a calibration curve is obtained by measuring at least two standard samples whose concentrations are known in advance, and the concentration is calculated from the absorbance based on the calibration curve. In this case, a calibration curve is re-created periodically in consideration of changes in the reagent over time, and a quality control sample with a known concentration (Quality Control) is used to guarantee the measurement result calculated based on the calibration curve. , QC sample, control sample, standard sample, etc.) are periodically measured (with a period shorter than the calibration curve re-creation period) to check the dispersion of the measurement results. As the quality control sample, it is common to use at least two kinds of samples having a zero concentration (such as physiological saline) and a sample having a preset concentration.

  In recent automatic analyzers, for the purpose of improving the processing speed, a plurality of analysis units are connected via a common transport line, and a sample (sample) is transported to the target analysis unit via the transport line for analysis. Things have been commercialized. In such an automatic analyzer, the quality control is realized by mounting the quality control sample on a rack and transporting it to the analysis unit via the transport line.

  As such an automatic analyzer, for example, one disclosed in Patent Document 1 is known.

JP 2000-227433 A

  In automatic analyzers that perform calibration measurements using conventional sample racks, calibration measurements using zero-concentration samples are generally performed by mounting a zero-concentration sample such as physiological saline in the sample rack. It was. For this purpose, it takes about 10 minutes to prepare a physiological saline as a zero concentration sample of a standard sample used for calibration measurement and a quality control sample used for quality control measurement per analysis item, and calibration measurement and In order to perform quality control measurement, a total work time of about 20 minutes was required for about 10 minutes.

  An object of the present invention is to provide means for carrying out accuracy control / calibration measurement using purified water used in the apparatus as a zero concentration standard sample in an automatic analyzer that performs calibration measurement using a sample rack. An object of the present invention is to provide an analyzer that automates operations for calibration measurement, reduces user work, and reduces work errors. In addition, by performing quality control measurement using purified water used in the equipment as a quality control sample, it is possible to confirm the denaturation of the reagent used, and to quickly take measures for quality control of the equipment, Another object of the present invention is to provide an analyzer capable of continuously realizing highly reliable analysis.

  In order to achieve the above object, an automatic analyzer according to the present invention is configured as follows. Storage means for storing in advance whether to use purified water used in the analyzer as a zero concentration standard sample for each analysis item or to use a standard sample prepared in advance at the sample mounting position When the execution of quality control measurement or calibration is instructed for the analysis item, the quality control measurement or calibration measurement is performed using purified water or a standard sample prepared in advance based on the information stored in the storage means. An automatic analyzer with a function to be executed using any of the above.

  The standard sample is also referred to as a standard solution. This is the name of a sample solution whose concentration is known in advance. Purified water is generally pure water produced by a pure water production machine, and is supplied to an automatic analyzer for use in washing or the like. The sample mounting position is a specimen (sample) disk in which a plurality of sample containers are arranged in a line on the circumference of a disk, or a modular automatic analysis system in which a plurality of analysis units are connected via a transport line. , Means a sample rack (about 1 to 5 sample containers can be mounted) set on the transport line.

  According to the present invention, in an automatic analyzer that performs a calibration measurement using a sample rack, in a calibration measurement using a zero concentration sample that is a standard sample that is most frequently used, purified water used in the device is supplied. By providing means for performing the used calibration measurement, it is possible to provide an analyzer that automates the operation for calibration measurement, reduces user work, and reduces work errors. In addition, by performing quality control measurement using purified water used in the equipment as a quality control sample, it is possible to confirm the denaturation of the reagent used, and to quickly take measures for quality control of the equipment, In addition, it is possible to realize an analyzer capable of continuously realizing highly reliable analysis and improving measurement accuracy. For example, in a conventional automatic analyzer, about 10 minutes are required to prepare a physiological saline as a zero concentration sample of a standard sample used for calibration measurement or a quality control sample used for quality control measurement per analysis item. In order to perform calibration measurement and quality control measurement, a total work time of about 20 minutes is required for about 10 minutes. On the other hand, by providing the present invention, the work is automated, the work time can be eliminated, and the management cost of the zero concentration sample can be reduced.

  The outline of one embodiment of the present invention will be described as follows.

  First, a means for setting and storing sample information of a single or a plurality of standard samples used in calibration measurement for each analysis item is provided. The sample information of the standard sample is information for identifying the standard sample (for example, a code or name for uniquely identifying the standard sample) and concentration information (a known concentration of the standard sample).

  Next, there is provided means for setting and storing in which position of which sample rack the sample information is mounted. Here, when using purified water in the analyzer, it is possible to omit setting the position in the sample rack by specifying the sample information that means purified water. . For example, if the sample identification code indicating purified water is defined as 999, the analyzer sets the sample identification code as 999 for the standard sample used in a certain analysis item, so that the analyzer selects the standard sample on the sample rack. Recognizing that purified water in the apparatus is used instead of using it, it is not necessary to set a sample rack for the standard sample.

  Next, the calibration measurement is performed according to the calibration measurement execution instruction input from the operation unit of the analyzer or the calibration measurement execution reservation (for example, timer reservation) input in advance by the user. For calibration measurement, first read the standard sample information set and stored in the analysis item to be calibrated, and if it is recognized that the calibration measurement uses only purified water, no sample rack installation is required. Immediately or indirectly, the purified water in the apparatus is directly or indirectly supplied to the in-apparatus equipment for controlling the sample supply equipment in the apparatus to perform calibration measurement, and the instrument control of the analyzer that performs the calibration measurement is performed. If it is recognized that the calibration measurement uses a combination of purified water and a standard sample mounted on the sample rack, it is detected that the sample rack is installed in the device (for example, the sample rack or the mounted sample Read the barcode attached to the container), and follow the set order based on the sample information of the standard sample used for the calibration measurement, and the standard sample mounted on the sample water and the sample rack Is directly or indirectly supplied to the in-apparatus equipment for measuring the calibration by controlling the in-apparatus sample supply equipment, and performs instrument control of the analyzer that performs the calibration measurement.

  In addition, there is provided means for setting and storing a determination parameter used for determination of the measurement data of the quality control sample. Judgment parameters are information that identifies a quality control sample (for example, a code or name that uniquely identifies the quality control sample), a reference upper / lower limit range (coefficient for control SD), and a calibration method (standard sample used for calibration measurement). Combination pattern).

  Next, there is provided means for setting and storing in which position of which sample rack the sample information is mounted. Here, when using purified water in the analyzer, it is possible to omit setting the position in the sample rack by specifying the sample information that means purified water. . For example, if the sample identification code indicating purified water is defined as 999, the sample identification code is set to 999 for the quality control sample used for a certain analysis item, so that the analyzer can perform quality control on the sample rack. Recognizing that purified water in the apparatus is used instead of using a sample, it is not necessary to set a sample rack for the quality control sample.

  Next, the quality control measurement is performed according to the quality control measurement execution instruction input from the operation unit of the analyzer or the quality control measurement execution reservation (for example, timer reservation) previously input by the user. For quality control measurement, first read the quality control sample information set and stored in the analysis item to be quality control measured, and if it is recognized that the quality control measurement uses purified water, there is no need to install a sample rack. Immediately or indirectly, the purified water in the apparatus is directly or indirectly supplied to the in-apparatus equipment for controlling the sample supply equipment in the apparatus to perform the accuracy control measurement, and the instrument control of the analyzer that performs the accuracy control measurement is performed.

  When a quality control sample is measured and measurement data is output, first, determination parameters and reference upper and lower limit values are read from the storage means. When the quality control sample is set as a determination parameter for the analysis item, the measurement data of the quality control sample and the reference upper and lower limit values are compared.

  If the measurement data of the quality control sample is outside the upper and lower limits, determine that the reagent used for the measurement in the analysis item has been denatured due to factors such as reagent deterioration, and provide recommended information for calibration measurement. The reagent information (reagent lot number, reagent manufacturing number, etc.) is stored in the storage means.

  The operation unit includes display and input means for confirming reagent information of analysis items for which remeasurement of calibration is recommended and easily requesting calibration measurement for the recommended reagent. Furthermore, a display and input means is provided that can easily confirm the measurement data of the quality control sample that is out of the reference upper and lower limits and re-measure the quality control sample.

  An operation screen for setting use of purified water used in the apparatus for a standard sample and a quality control sample used in calibration measurement and quality control measurement is provided. In addition, when an instruction to execute calibration measurement and quality control measurement with purified water is input, it is necessary to control the sample supply equipment in the instrument and calibrate it immediately without the need to install a sample rack. It is directly or indirectly supplied to the equipment in the apparatus for measurement and quality control measurement, and has an instrument control function of an analyzer for performing calibration measurement and quality control measurement. An operation screen for presetting upper and lower reference values for determining measurement data of the quality control sample and an operation screen for recommending and displaying calibration remeasurement for the reagent of the analysis item outside the reference range are provided.

  Examples of the present invention will be described below.

  FIG. 1 is a block diagram showing an embodiment of an automatic analyzer according to the present invention. A user 101 is an operator who uses the analyzer to perform analysis work, and installs a sample rack and operates the analyzer. The operation unit 102 includes, for example, a keyboard and a CRT, and performs operations such as setting of standard samples and quality control samples for each analysis item, instructions for calibration and quality control measurement, confirmation of measurement results and recommended information, and the like. It is. The storage unit 103 is composed of a hard disk or the like, and stores standard samples, quality control sample settings, calibration and quality control measurement results, calibration measurement recommendation information, and the like. The data processing unit 104 performs data processing on analysis instructions and measurement results based on settings related to calibration and quality control measurement. The analysis unit 105 performs equipment control for dispensing and measuring the sample. The timer 106 manages time in order to perform calibration and accuracy management measurement according to a reservation set by the date and time and the cycle.

FIG. 2 shows a screen configuration for setting and displaying a standard sample used in calibration measurement for the analysis items registered in the analyzer using the operation unit 102. Reference numeral 201 denotes a list of analysis items registered in the analysis apparatus. Reference numeral 202 denotes an analysis item selection button for selecting an analysis item from the analysis item list. When the analysis item is selected, the setting relating to the standard sample used in the analysis item selected in 203 is read from the storage unit 103 and displayed. The standard sample code 204 is set with a number that uniquely identifies the standard sample to be used. When specifying purified water as a standard sample, 999, which is a number indicating purified water, is set. In the standard sample name 205, the name of the standard sample is set. When 999 is set in 204, it is automatically displayed as purified water. 206 is the amount of standard sample dispensed, 207 is the standard sample concentration, 208 is
Is the number of the sample mounting rack on which the standard sample is mounted, and 209 is the mounting position in the sample rack. Note that when 999 is set to 204, the sample mounting rack is not used, so that setting of 208 and 209 is unnecessary. Reference numeral 210 denotes a button for canceling data set on this screen. Reference numeral 211 denotes a button for storing data set on this screen in the storage unit 103.

  FIG. 3 shows a screen configuration for setting and displaying a quality control sample used for quality control measurement on the operation unit 102 for the analysis items registered in the analysis apparatus. Reference numeral 301 denotes a list of analysis items registered in the analysis apparatus. Reference numeral 302 denotes an analysis item selection button for selecting an analysis item from the analysis item list. When an analysis item is selected, the setting relating to the quality control sample used in the selected analysis item is read from the storage unit 103 and displayed. In the quality control sample code 304, a number for uniquely identifying the quality control sample to be used is set. When the purified water is designated as the quality control sample, 999, which is a number indicating the purified water, is set specially. In the quality control sample name 305, the name of the quality control sample is set. When 999 is set in 304, it is automatically displayed as purified water. In 306, the dispensing amount of the quality control sample is set, in 307, the number of the sample mounting rack on which the quality control sample is mounted is set, and in 308, the mounting position in the sample rack is set. If 999 is set to 304, the sample mounting rack is not used, so the settings of 307 and 308 are unnecessary. 309 is an allowable upper limit value for the quality control measurement result, 310 is an allowable lower limit value for the quality control measurement result, 311 is an average value targeted for the quality control measurement result, and 312 is a target of the quality control measurement result. Set the standard deviation value. When the quality control measurement result exceeds the range of 309 and 310, it becomes a recommended target for calibration measurement. Reference numeral 313 denotes a button for canceling the data set on this screen. Reference numeral 314 denotes a button for storing data set on this screen in the storage unit 103.

FIG. 4 is a screen configuration for performing calibration and quality control measurement instructions and reservations on the operation unit 102 for the analysis items registered in the analysis apparatus. 401 is a list of analysis items registered in the analyzer. Reference numeral 402 denotes an analysis item selection button for selecting an analysis item from the analysis item list. Reference numeral 403 denotes a button for instructing start of calibration measurement for the analysis item selected in 402. Reference numeral 404 denotes a button for instructing start of quality control measurement for the analysis item selected in 402. When an analysis item is selected in 402, the calibration measurement reservation information for the analysis item selected in 405 and the quality control measurement reservation information for the selected analysis item are read out from the storage unit 103 and displayed in 406. For the date and time designation reservation for the calibration measurement, a date is set in 406 and a time is set in 407. For the reservation of the cycle designation, the number of cycles is designated in 408, and the cycle unit is designated in 409. The cycle unit 409 is selected from minute, hour, day, and month. Reference numeral 410 denotes a button for confirming a reservation for calibration measurement based on the information set in 406 to 409 and storing it in the storage unit 103. For appointments with date and time designation for quality control measurements, set the date to 412,
The time is set at 413. Regarding the reservation for specifying the cycle, the number of cycles is specified in 414 and the cycle unit is specified in 415. The cycle unit 415 is selected from minute, hour, day, and month. Reference numeral 416 denotes a button for confirming a reservation for quality control measurement based on the information set in 412 to 415 and storing it in the storage unit 103.

  FIG. 5 shows an example of the overall configuration of the apparatus combining the transport equipment of the sample mounting rack and the analysis unit. The sample rack input unit 501 is a facility for the user 101 to input a sample mounting rack 502 on which a sample for calibration or accuracy control measurement is mounted, and a plurality of sample mounting racks may be installed according to the user's purpose. it can. The sample mounting rack loaded into the sample rack loading unit is transported by the sample rack transport unit 503 to an analysis unit that actually performs calibration or quality control measurement among a plurality of analysis units 504 connected to the sample rack transport unit. Measurement is performed. The sample mounting rack for which the measurement has been completed is transported and stored in the sample rack storage unit 505 by the sample rack transport unit.

FIG. 6 is a configuration diagram illustrating an example of detailed equipment of the analysis unit. Reference numeral 601 denotes a base on which the equipment of the analysis unit is mounted. Reference numeral 602 denotes a sample container for storing a standard sample and a quality control sample.
Reference numeral 603 denotes a sample mounting rack on which a plurality of sample containers can be mounted. When there is a measurement instruction, the sample mounting rack transported by the sample rack transporting unit 503 in FIG. 5 is transported into the analysis unit by the sample rack transporting / unloading facility 605, and the barcode 604 attached to the sample mounting rack is installed in the apparatus. When the barcode reader 606 reads, the sample information is collated with the sample information stored in the storage unit 103 to recognize the sample. The recognized sample is dispensed to the measurement reaction facility 611 by the sample supply facility 607, and the reagent filled in the reagent container 613 stored in the reagent storage 612 is added to the measurement reaction facility by the reagent supply facility 614. Measure with. When the sample information that is collated with the sample information stored in the storage unit 103 and used in calibration or quality control measurement is purified water, purified water is supplied from the pure water device 608 connected to the analyzer via the tube 609. The purified water supplied to the mouth 610 is measured by being dispensed to the measurement reaction facility 611 by the sample supply facility 607. The sample mounting rack for which the measurement has been completed is carried out to the sample rack transport unit 503 in FIG. 5 by the sample rack carry-in / out facility.

FIG. 7 shows a screen configuration for displaying the measurement results of calibration and quality control measurement on the operation unit 102 for the analysis items registered in the analyzer. Reference numeral 701 denotes a list of analysis items registered in the analysis apparatus. Reference numeral 702 denotes an analysis item selection button for selecting an analysis item from the analysis item list. When an analysis item is selected in 702, the calibration measurement result information for the analysis item selected in 703 and the quality control measurement result information for the analysis item selected in 710 are read from the storage unit 103 and displayed. As the result information of the calibration measurement of 703, the absorbance value of the standard sample 1 is displayed in 704, the proportionality constant used in the concentration calculation is displayed in 705, and the correction coefficient used in the concentration calculation is displayed in 706 and 707. As the result information of the accuracy management measurement of 710, from the information set and stored in FIG. 3, the setting management upper limit value is set to 711, the setting management lower limit value is set to 712, the setting management average value is set to 713, and 714
The setting management standard deviation value is displayed. As statistical value information, the number of quality control measurements is displayed in 715, the average value of the measurement results is displayed in 716, and the standard deviation value of the measurement results is displayed in 717. In addition, by selecting the measurement order in 718, the selected measurement value is displayed in 719. Further, when the latest measured value exceeds the range of 711 and 712, recommended information recommending remeasurement of calibration is displayed in 708 because the quality control measurement value is abnormal. Further, in 709, there is a possibility that the reagent is denatured based on the quality control measurement result, and alarm information for warning that the calibration is measured again or the reagent is replaced is displayed.

  FIG. 8 is a processing flow at the time of calibration measurement. It is determined whether the calibration measurement reservation time set in FIG. 4 has been reached or whether a calibration measurement instruction has been input (801). If the condition is satisfied, it is determined whether the standard sample used in the analysis item set in FIG. 2 is only purified water (802). When the standard sample to be used is only purified water, the purified water is controlled by the sample supply facility 607, the purified water is sucked from the purified water supply port 610, and dispensed to the measurement reaction facility 611 (804) for calibration. Measurement (809). If the standard sample to be used is not only purified water, it is determined whether the sample mounting rack 603 has arrived at the dispensing position. When it arrives, it is determined whether the standard sample used this time is purified water (805). In the case of purified water, the purified water is sucked from the purified water supply port 610 by controlling the sample supply facility 607 and dispensed to the measurement reaction facility 611 (806), and then used for the analysis item. It is determined whether all standard samples to be dispensed have been dispensed (808). When all of them are dispensed, calibration measurement is performed (809). If not all dispensed, the process returns to 805 to dispense all. If the determination result of 805 is not purified water, the standard sample is sucked from the sample mounting rack 603 by controlling the sample supply facility 607 and dispensed to the measurement reaction facility 611. After dispensing, proceed to 808.

  FIG. 9 is a processing flow at the time of quality control measurement. It is determined whether the quality control measurement reservation time set in FIG. 4 has been reached or a quality control measurement instruction has been input (901). If the condition is satisfied, it is determined whether the quality control sample used in the analysis item set in FIG. 3 is purified water (902). When the quality control sample to be used is purified water, the purified water is sucked from the purified water supply port 610 by controlling the sample supply facility 607 and dispensed to the measurement reaction facility 611 (905). Management measurement is performed (906). If the quality control sample to be used is not purified water, it is determined whether the sample mounting rack 603 has arrived at the dispensing position. When the sample arrives, the quality control sample is controlled by the sample supply facility 607, sucked from the sample mounting rack 603, and dispensed to the measurement reaction facility 611. After dispensing, quality control measurement is performed (906).

FIG. 10 is a calibration recommended information update processing flow at the time of quality control measurement. When the quality control measurement result is output (1001), it is determined whether or not the measured value is outside the range of the quality control upper limit value 309 and the quality control lower limit value 310 of the analysis item set in FIG. 3 (1002). . If the determination result is out of the range, recommended information for calibration of the analysis item is created and stored in the storage unit 103 (1003). Further, in 709, there is a possibility that the reagent is denatured from the quality control measurement result, and alarm information for warning that the calibration is remeasured or the reagent is replaced is displayed (1005). The recommended information for calibration of the analysis item is deleted and stored in the storage unit 103 (1004). The recommended calibration information can be confirmed on the screen of FIG. 7, and a remeasurement of calibration can be requested on the screen of FIG. After performing the processing 1005 and 1004, the measurement data is stored in the operation unit 102 (1006). This measurement data can be confirmed on the screen of FIG.

It is a block diagram which shows the basic outline of the analyzer which is one Embodiment of this invention. It is an example of a screen for setting a standard sample used for calibration measurement. It is an example of a screen which sets the quality control sample used by quality control measurement. It is an example of an instruction screen for calibration and quality control measurement. It is the example of the whole apparatus structure which combined the conveyance equipment and analysis part of the sample rack. It is a detailed equipment configuration example of an analysis part. It is an example of a screen which displays the result of calibration and quality control measurement. It is the flowchart which showed the calibration measurement process. It is the flowchart which showed quality control measurement processing. It is the flowchart which showed the calibration recommendation information update process at the time of quality control measurement.

Explanation of symbols

DESCRIPTION OF SYMBOLS 101 ... User, 102 ... Operation part, 103 ... Memory | storage part, 104 ... Data processing part, 105,504 ... Analysis part, 106 ... Timer, 201, 301, 401, 701 ... Analysis item list, 202, 302, 702 ... Analysis Item selection button, 203 ... Standard sample setting area, 204 ... Standard sample code, 205 ... Standard sample name, 206 ... Dispensing amount, 207 ... Concentration, 208,
307: Mounting rack number, 209, 308 ... Position in mounting rack, 210, 313 ... Cancel button, 211, 314 ... Storage button, 303 ... Quality control sample setting area, 304 ... Quality control sample code, 305 ... Quality control sample name 306: Dispensing amount 309: Quality control upper limit value 310: Quality control lower limit value 311: Quality control average value 312: Quality control deviation value 402: Analysis item selection button 403: Calibration measurement start button 404 ... Quality control measurement start button, 405 ... Calibration measurement reserved area, 406, 412 ... Reserved date, 407, 413 ... Reserved time, 408, 414 ... Cycle, 409, 415 ... Cycle unit, 410, 416 ... Reserve button, 411 ... Quality control measurement reservation area, 501 ... Sample rack input section, 502, 603 ... Test Mounting rack, 503 ... Sample rack transport section, 505 ... Sample rack storage section, 601 ... Analysis section base, 602 ... Sample container, 604 ... Bar code, 605 ... Sample rack loading / unloading facility, 606 ... Bar code reader, 607 ... Sample Supply equipment, 608 ... pure water device, 609 ... tube, 610 ... purified water supply port, 611 ... measurement reaction equipment, 612 ... reagent storage, 613 ... reagent container, 614 ... reagent supply equipment, 703 ... calibration measurement result display area 704 ... Standard sample 1 absorbance value, 705 ... Concentration constant for calculation, 706 ... Correction coefficient A, 707 ... Correction coefficient B, 708 ... Calibration recommended information, 709 ... Alarm information, 710 ... Quality control measurement result display area, 711 ... Setting management upper limit value, 712 ... Setting management lower limit value, 713 ... Setting management average value, 714 ... Setting management Quasi-deviation value, 715 ... the number of measurement, 716 ... the measured average value, 717 ... measurement standard deviation value, 718 ... measurement times following selection, 719 ... measurement value.

Claims (6)

Storage means for storing in advance whether to use purified water used in the analyzer as a zero concentration standard sample for each analysis item or to use a standard sample prepared in advance at the sample mounting position With
When execution of quality control measurement or calibration is instructed for the analysis item, either quality control measurement or calibration measurement is performed using purified water or a standard sample prepared in advance based on the information stored in the storage means. An automatic analyzer characterized by having a function to be executed using a computer. The automatic analyzer according to claim 1,
The automatic analyzer according to claim 1, wherein the sample mounting position is a sample rack for transporting a sample to the analyzer via a transport line. The automatic analyzer according to claim 1,
The storage means displays a screen as to whether to use purified water used in the analyzer or a standard sample prepared in advance as a sample mounting position as a zero concentration standard sample for each analysis item. An automatic analyzer characterized by comprising an input means capable of instructing above. The automatic analyzer according to claim 1,
When an instruction to perform quality control or calibration measurement is input, if the zero-concentration standard sample used in the quality control or calibration measurement is designated as purified water,
An automatic analyzer comprising control means for dispensing purified water into a reaction container of an automatic analyzer using a reagent dispensing probe or a sample dispensing probe to perform quality control measurement or calibration measurement. The automatic analyzer according to claim 4,
When the zero-concentration standard sample used for quality control measurement or calibration measurement is set with a combination of a pre-prepared standard sample set at the sample mounting position and purified water in the analyzer,
An automatic analyzer comprising control means for controlling to perform calibration measurement by combining a standard sample set at a sample mounting position and purified water in the analyzer. The automatic analyzer according to claim 4,
When the automatic analyzer starts up or when the preset start-up time is reached, the automatic analyzer supplies the purified water in the analyzer to the reaction vessel and does the calibration measurement automatically without requiring user operation. An automatic analyzer characterized by comprising control means for controlling.

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