JP2007167576A - Prefilled syringe and combination of syringe and adapter - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a prefilled syringe and a combination of the prefilled syringe and an adapter preventing a medical solution of which rapid intravenous injection is disapproved, from being erroneously rapidly intravenous injected from a three-way cock and other mixed injection port such as a side injection port. <P>SOLUTION: This prefilled syringe 10 is provided with a male thread part 13 around the outer circumference of a tubular projecting wall part 12, and a step part 17 at the base part of the tubular projecting wall part 12. The adapter 20 to be attached to the prefilled syringe 10 has an external tube body 21 having a female thread part 23 threadedly engaged with the male thread part 13, and an internal tube body 22 coming into contact with the inner wall of the tubular projecting wall part 12 in the inward side of the external tube body 21. The adapter 20 has a hollow body part 25 having a second medical solution pathway 26 communicated with a first medical solution pathway of the internal tube body 22 and having a closed one end, and a tapered needle-shaped shaft body 27 integrally formed with the hollow body part 25, formed with a long groove part 28 along the axial direction around the outer circumference and formed with an open pathway 29 communicating the long groove part 28 with the second medical solution pathway 26 of the hollow body part 25. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a medical prefilled syringe pre-filled with a chemical solution, and more particularly to a technique for preventing erroneous connection and erroneous injection of a prefilled syringe.

  Conventionally, various chemical solutions have been injected into a living body through a tube from a chemical solution bag, or injected into a living body from a mixed injection port provided in the middle of the tube. At that time, there is a chemical solution that should not be injected into the living body without diluting it with a saline solution. Such a chemical solution is once mixed and diluted in a chemical solution bag or bottle, and then injected into the living body. Have been instructed.

  However, due to the operator's mistake, the prefilled syringe filled with the diluted drug solution is misconnected to the mixed injection port provided in the infusion set or blood transfusion set, etc., and the diluted drug solution is left as it is (without dilution) to the human body. The danger of intravenous injection has been pointed out.

  In such a background, there is a strong demand for a syringe structure having a mechanism for preventing a prefilled syringe filled with a diluted drug solution from being erroneously connected to a mixed injection port.

  When the inventor measured various sizes of a normal prefilled syringe currently used (for example, Patent Document 1) and a co-injection port, the connection part of the prefilled syringe filled with the diluted drug solution, There was no difference in size and shape from the connection part of the prefilled syringe, and there was a risk of erroneously connecting the prefilled syringe filled with the diluted drug solution to the mixed injection port. The inventor has made various studies in view of whether it is possible to make a structure that cannot be physically misconnected by devising the shape and size of the syringe and various co-infusion ports, etc., in order to prevent artificial misconnection. did.

  As a result, if the nozzle outer diameter at the tip of the syringe is increased, a prefilled syringe filled with a drug solution that should not be directly administered without changing the size or shape of the conventional mixed injection port or the like has been It was found that it could not be connected to the mixed injection port.

Conventionally, as such a syringe structure, the outer diameter and inner diameter of the nozzle part at the tip of the syringe are increased so that it cannot be connected to a normal mixed injection port, a male screw part is provided on the outer periphery of the nozzle part, There has been known one in which a needle-shaped adapter is interposed for connection (Patent Documents 2 and 3).
JP 2004-344423 A JP 2002-159576 A JP 2003-047658 A

  However, in the above-described Patent Documents 2 and 3, since the nozzle portion is thick, the nozzle portion itself cannot be inserted or held in the mixed injection port. However, since the tip of the needle attached to the nozzle can be inserted into the co-infusion port lumen, if the syringe piston is pushed in such a state, the drug solution to be diluted and used remains at a high concentration, Risk of being injected into the body.

  Although not shown, normally, the cap is attached to the nozzle portion of the prefilled syringe until use so that the filled diluted drug solution is not contaminated. In that case, since the male screw is formed on the outer periphery of the nozzle portion, the sealing performance between the nozzle portion and the adapter becomes a problem.

  The objective of this invention is providing the prefilled syringe which prevents that the chemical | medical solution which should be used after diluting is inject | poured accidentally with high concentration from mixed injection ports, such as a three-way stopcock and other side injection ports. . Furthermore, it aims at providing the combination of the said prefilled syringe and the cap which can be liquid-tightly joined to it.

  The invention of claim 1 includes a chemical solution storage portion pre-filled with a chemical solution, a cylindrical protruding wall portion that forms an opening for discharging the chemical solution filled in the chemical solution storage portion, and an outer periphery of the cylindrical protruding wall portion. A prefilled syringe having a formed nozzle portion having a male screw portion and a chemical solution discharge mechanism for discharging the chemical solution in the chemical solution storage portion, wherein the outer diameter of the cylindrical protruding wall portion is 4.3 mm to 5.4 m. It is the composition which is.

  The invention according to claim 2 is provided with a chemical solution storage portion pre-filled with a chemical solution, a cylindrical protruding wall portion that forms an opening for discharging the chemical solution filled in the chemical solution storage portion, and an outer periphery of the cylindrical protruding wall portion. A pre-filled syringe having a formed nozzle portion having a male screw portion and a chemical solution discharge mechanism for discharging a chemical solution in the chemical solution storage portion, the cylindrical protruding wall having the male screw portion at the base of the nozzle portion It is the structure provided with the step part which has an outer diameter larger than the outer diameter of a part.

  A third aspect of the present invention is the prefilled syringe according to the first or second aspect, wherein a throttle portion having an opening diameter smaller than the inner diameter of the cylindrical protruding wall portion is provided on the inner peripheral side of the cylindrical protruding wall portion. It is.

  According to a fourth aspect of the present invention, in the prefilled syringe according to the second aspect, a throttle portion having an opening diameter smaller than the inner diameter of the cylindrical protruding wall portion is provided at a connection portion between the stepped portion and the cylindrical protruding wall portion. It is the structure provided.

  A fifth aspect of the present invention is the prefilled syringe according to the third or fourth aspect, wherein the inner diameter of the cylindrical projecting wall portion is formed in a tapered shape that gradually decreases from the tip toward the throttle portion. It is.

  The invention of claim 6 has an adapter that can be connected to the prefilled syringe according to any one of claims 1 to 5, and the adapter has a female screw portion that is screwed into the male screw portion of the nozzle portion. An outer cylindrical body having an inner periphery, an inner cylindrical body that is in contact with the inner wall of the cylindrical protruding wall portion on the inner side of the outer cylindrical body, and in which a first chemical liquid passage is formed; and A tapered body formed with a hollow body portion having a second chemical liquid passage that is communicated with the first chemical liquid passage and closed at one end, and an opening passage that opens the second chemical liquid passage of the hollow body portion to the outer periphery. A needle-like shaft body, and the outer cylinder body, the inner cylinder body, and the hollow body portion are integrally formed.

  A seventh aspect of the invention is a combination of the prefilled syringe and the adapter according to the sixth aspect, wherein the distance from the tip of the needle shaft to the communication path is 15 to 30 mm.

  The invention of claim 8 is a combination of the prefilled syringe and the adapter according to claim 6 or 7, wherein the end of the inner cylinder is formed to be retracted inside the end of the outer cylinder. It is the composition which is.

  A ninth aspect of the present invention is the prefilled syringe according to any one of the fourth to eighth aspects, further comprising a cap for sealing the nozzle portion of the prefilled syringe, wherein the cap contacts the outer periphery of the stepped portion. A cap main body having a contact portion to be sealed on the inner surface, a first seal surface to be in contact with the inner peripheral surface of the cylindrical protruding wall portion of the prefilled syringe, and an opening in the throttle portion to be sealed. And a projecting portion having two sealing surfaces.

  In the invention of claim 1, since the outer diameter of the nozzle portion of the prefilled syringe prefilled with the chemical solution is larger than the opening portion of the normal co-infusion port, it is possible to prevent erroneous connection.

  In invention of Claim 2, it can seal with the cap and step part which cover a nozzle part, and is excellent in sealing performance.

  In the invention of claim 3, by setting the size of the aperture of the throttle part to be the same as that of a conventional syringe, the discharge state of the chemical liquid in the chemical liquid storage part can be made the same as the conventional state. Can be used without any sense of incongruity. It can also be used for chemical solutions that do not require the injection state to be as fast as conventional. Moreover, this throttle part can also be used as a seal part of a cap, and the utilization range is remarkably excellent.

  In the invention of claim 4, since the discharge state of the liquid medicine in the liquid medicine storage part can be made the same as the conventional state by setting the opening size of the throttle part to the same size as a conventional syringe, an operator such as a nurse Can be used without any sense of incongruity. It can also be used for chemical solutions that do not require the injection state to be as fast as conventional.

  Moreover, this throttle part can also be used as a seal part of a cap, and the utilization range is remarkably excellent.

  In the invention of claim 5, even when a large opening is provided in the nozzle portion, the sealing performance with the cap can be improved.

  In the invention of claim 6, even if the adapter is mistakenly connected to the co-infusion port, the chemical liquid leaks out from the opening passage of the adapter, so that it can be quickly noticed that the adapter has been mistakenly connected.

  According to the seventh aspect of the present invention, since the open passage is exposed to the outside with respect to a general ordinary co-infusion port, it is possible to quickly notice that the connection is made by mistake.

  In invention of Claim 8, it can prevent that an inner cylinder is damaged accidentally.

  In invention of Claim 9, a syringe can be reliably sealed with the simple cap only covered from the outer side.

  1 to 6 show a prefilled syringe according to an embodiment of the present invention. As shown in FIG. 1, the prefilled syringe 10 includes a chemical solution storage unit 11 that is formed in a cylindrical shape and is prefilled with a chemical solution. A nozzle portion 15 is provided at the distal end portion of the chemical solution storage portion 11. The nozzle portion 15 has a cylindrical protruding wall portion 12 that forms an opening for discharging the chemical solution filled in the chemical solution storage portion 11, and has a male screw portion 13 on the outer periphery of the cylindrical protruding wall portion 12. . A chemical solution discharge mechanism 16 that discharges the chemical solution in the chemical solution storage unit 11 is provided at the rear end portion of the prefilled syringe 10.

  The detailed structure of the nozzle unit 15 will be described with reference to FIG. A male screw portion 13 is formed on the outer periphery of the cylindrical protruding wall portion 12. A stepped portion 17 having an outer diameter that is slightly larger than the cylindrical protruding wall portion 12 is provided at the base of the cylindrical protruding wall portion 12. A throttle portion 18 is integrally formed at the connecting portion between the base portion of the cylindrical protruding wall portion 12 and the step portion 17. The opening diameter r3 of the opening 19 of the throttle section 18 is 1.8 mm, which is the same as or similar to the opening diameter of a syringe that has been conventionally used.

  The inner diameter r2 of the cylindrical projecting wall portion of the nozzle portion 15 of the present embodiment is about 3.5 mm, which is considerably larger than the inner diameter of the nozzle portion of the conventional syringe, but the opening diameter of the opening portion 19 of the throttle portion 18 is conventional. By using the same diameter as the inner diameter of the nozzle portion of the syringe, the chemical solution in the chemical solution storage unit 11 is prevented from being ejected in a large amount more rapidly than in the past. In addition, the operator can operate without feeling uncomfortable with the discharge state of the conventional syringe.

  As shown in FIG. 3, in the unused state, the nozzle portion 15 of the prefilled syringe 10 is covered with a rubber cap 30. The rubber cap 30 includes a hollow portion 32 having an inner diameter that elastically engages with the male screw portion 13 formed on the outer periphery of the cylindrical protruding wall portion 12 of the prefilled syringe 10, and is connected to the hollow portion 32. The cap body 31 includes a contact portion 33 having an inner diameter slightly larger than the cavity portion 32.

  Further, a protrusion 34 is formed integrally with the cap body 31 inside the cap body 31. The protruding portion 34 has a substantially conical shape that tapers in the direction of the throttle portion 18, and a first seal surface 35 and a throttle portion that contact and seal the inner peripheral surface 14 of the cylindrical protruding wall portion 12 at the root portion. A second sealing surface 36 is provided to contact and seal the 18 openings 19.

  When the rubber cap 30 is fitted into the nozzle portion 15, the contact portion 33 is sealed by elastically and closely contacting the outer periphery of the step portion 17. Further, the first seal surface 35 of the projecting portion 34 contacts and seals with the inner peripheral surface 14 of the cylindrical projecting wall portion 12, and the second seal surface 36 is sealed by fitting into the opening 19 of the throttle portion 18. It is like that. As described above, the first seal surface 35 and the second seal surface 36 prevent the chemical liquid from leaking and can be reliably sealed. In addition, the restricting portion 18 may make it difficult for the chemical solution in the chemical solution storage portion 11 to leak out by reducing the opening diameter of the opening portion 19.

  In this embodiment, the cap portion 30 is put on the nozzle portion 15 so that the contact portion 33 fits closely with the stepped portion 17, so that the cap 30 is held by the nozzle portion 15 without coming off, and the seal portion 34. , 35 is surely sealed, so that workability such as insertion and removal of the cap 30 is excellent.

  The adapter 20 will be described with reference to FIG. The base portion of the adapter 20 made entirely of needle-shaped plastic is attached to the nozzle portion 15 of the prefilled syringe 10. Specifically, the adapter 20 includes an outer cylindrical body 21 having an internal thread portion 23 screwed into the external thread portion 13 on the inner periphery, and an inner cylindrical body 22 formed on the inner side of the outer cylindrical body 21. . The outer side of the inner cylindrical body 22 is a tapered surface that can come into contact with the inner wall of the cylindrical projecting wall portion 12, and a first chemical liquid passage 24 is formed in the center of the inner cylinder 22. In the hollow body portion 25, a second chemical liquid passage 26 communicating with the first chemical liquid passage 24 of the inner cylinder 22 is formed at the inner center, and one end of the second chemical liquid passage 26 is closed. The hollow body portion 25 is formed integrally with the inner cylinder body 22 and the outer cylinder body 21 to form an elongated needle-shaped body portion. A tapered needle-like shaft body 27 is integrally provided at the tip of the hollow body portion 25. Three long groove portions 28 along the axial direction are formed on the outer periphery of the needle-like shaft body 27 at intervals of 120 degrees. The long groove portion 28 and the second chemical liquid passage 26 of the hollow body portion 25 are communicated with each other through an opening passage 29.

  The distance H from the tip of the needle shaft 27 to the opening passage 29 is in the range of 15 to 30 mm. Normally, even if the adapter 20 is inserted into the mixed injection port, the opening passage 29 is exposed outside the mixed injection port (disk valve). The length is set so that it can be normally injected when mixed into a medical solution bag or bottle for dilution. With this configuration, even when the adapter is mistakenly inserted into the mixed injection port, the liquid in the prefilled syringe does not flow into the mixed injection port. Depending on the type and standard of the mixed injection port, there is a vertically long type. In such a mixed injection port, there is a risk that the opening passage 29 will enter the lumen of the mixed injection port and the diluted drug solution may be directly injected. . Therefore, it is preferable that the thickness of the distal end side of the needle-shaped shaft body 27 (the portion from the distal end to the opening passage 29 excluding the most pierced portion) is 3.5 to 4.5 mm. Because the disk valve of the vertically long mixed injection port has a small outer diameter and the slit diameter formed in the valve is small, if the tip side thickness of the needle-shaped shaft body is in the above range, the adapter distal end side becomes a vertically long mixed injection port. It cannot be inserted deeply. As a result, even if only the adapter tip can be inserted into the co-infusion port, the drug solution in the syringe cannot be injected. If the tip-side thickness of the needle-shaped shaft body 27 is 3.5 mm or less, the adapter is inserted deeply into the vertically long mixed injection port, and there is a risk of erroneous injection. On the other hand, when the adapter thickness is 4.5 mm or more, it is necessary to puncture and bond the adapter to the drug solution bag at the time of dilution, but it is difficult to puncture and bond the adapter. The end 22a of the inner cylinder 22 is formed by being retracted inward from the end 21a of the outer cylinder 21, so that the inner cylinder 22 can be prevented from being damaged by anything.

  As shown in FIG. 5, the adapter 20 is accommodated in the protector 40 when not in use. The protector 40 includes a hollow part 42 that accommodates the hollow body part 25 and the needle-shaped shaft body 27 of the adapter 20, and a cup part 41 that accommodates the outer cylinder 21. A holding portion 43 that holds the base portion of the hollow body portion 25 is formed at a connection portion between the cup portion 41 and the hollow portion 42.

  The use state will be described with reference to FIG. The adapter 20 is taken out from the protector 40 and the cap 30 is removed from the nozzle portion 15 of the prefilled syringe 10. Then, the adapter 20 is attached to the nozzle portion 15. At that time, the female screw portion 23 of the outer cylindrical body 21 is screwed into the male screw portion 13 of the cylindrical projecting wall portion 12. At the same time, the outer peripheral surface 22b of the inner cylindrical body 22 comes into strong contact with the inner peripheral surface 14 of the cylindrical protruding wall portion 12 and is sealed to each other. That is, the inner peripheral surface 14 of the cylindrical protruding wall portion 12 is formed in a taper that gradually narrows in the direction of the throttle portion, and the outer peripheral surface 22b of the inner cylindrical body 22 extends from the end portion 22a to the back side (hollow body portion). It is formed in a taper that gradually widens in the direction. Sealing properties are ensured by bringing the tapered surfaces into close contact with each other.

  A state of connecting to the mixed injection port will be described with reference to FIGS. For example, a bottle needle 101 is pierced into the mouth portion of the chemical solution bag 100, an infusion tube 102 is connected to the bottle needle 101, and sequentially connected to a backflow prevention valve 103, a mixed injection port 104, a roller clamp 105, and a mixed injection port 106, It is connected to a venous needle 107 that punctures the patient.

  In the case of such a chemical liquid circuit, another chemical liquid can be supplied from the mixed injection port 104 and the mixed injection port 106.

  When the mixed injection port 104 is a mixed injection port as shown in FIG. 8, a disc valve 111 having a slot (not shown) in the center is attached to the main body 110 with a cover 112. When the needle shaft 27 of the adapter 20 is inserted into the mixed injection port 110 with the adapter 20 attached to the prefilled syringe 10 as shown in FIG. 6, the opening passage 29 of the adapter 20 is mixed and injected. Since it is exposed to the outside of the port 110, anyone can immediately recognize that it is a misconnection, and no accidental injection can be made, thereby preventing an accident.

  As described above, when the opening passage 29 of the adapter 20 is a vertically long mixed injection port that is accommodated in the lumen of the mixed injection port, an adapter attached to the prefilled syringe 10 may be directly connected to the mixed injection port 110. Since the outer diameter of the needle shaft 27 is 4.0 mm and larger than the notch of the disc valve 111, the needle shaft 27 cannot be inserted and held in the disc valve.

  Thus, it is possible to prevent the prefilled syringe 10 filled with the chemical solution that needs to be diluted and injected from being erroneously connected to the co-infusion port 110.

  The state of connection to the side note port 106 in FIG. 7 will be described with reference to FIG. A valve body 122 made of a rubber elastic body is attached to the connection port 121 of the side injection port 106. A slit (not shown) is formed in the central portion of the valve body 122 so that a normal syringe or needle body can be pierced and connected.

  When it is going to connect the prefilled syringe 10 filled with the chemical | medical solution of this invention to this side injection port 106, the outer diameter R1 of the cylindrical protrusion wall part 12 of the prefilled syringe 10 is the outer diameter of the valve body 122 (of the connection port 121). Therefore, the cylindrical projecting wall portion 12 of the prefilled syringe 10 cannot be inserted. Further, when the adapter 20 is inserted into the prefilled syringe 10 and then inserted into the connection port 121, it can be inserted, but since the opening passage 29 is exposed from the connection port 121, the chemical solution leaks out. As a result, it is clear that the connection is incorrect.

  The outer diameter of the cylindrical protruding wall portion 12 needs to be larger than the outer diameter of the valve body 122 of the side injection port 106 (the inner diameter of the connection port 121). Also, if the outer diameter of the cylindrical projecting wall portion 12 is too large, the inner diameter of the cylindrical projecting wall portion becomes too large, and there is a possibility that it will be covered from the outside of the side injection port 106 and connected. Don't be too big. Therefore, it is preferable that the outer diameter of the cylindrical protruding wall portion 12 is 4.3 mm to 5.4 mm.

  In the above embodiment, three long groove portions 28 and three opening passages 29 are provided at intervals of 120 degrees. However, the number is not limited to this, and one or other plural number may be used. In the above embodiment, the long groove portion 28 is provided so that the chemical solution is smoothly guided in the direction of the needle tip. However, the long groove portion 28 is not necessarily required, and only the opening passage 29 may be provided.

  The structure of the mixed injection port is not limited to that shown in FIGS. 7 to 9 and can be applied to other mixed injection ports in the same manner, and the type of the mixed injection port is not limited.

  As described above, the prefilled syringe according to the present invention and the combination of the syringe and the adapter can be used when the diluted drug solution is once mixed and diluted in a drug solution bag or bottle.

The sectional view of the prefilled syringe concerning the embodiment of the present invention is shown. It is a principal part enlarged view of FIG. It is a figure explaining the state which fits a cap to the prefilled syringe of FIG. Sectional drawing of the adapter concerning embodiment is shown. The state which accommodated the adapter of FIG. 4 is shown. It is sectional drawing which shows the state which attached the adapter to the prefilled syringe concerning embodiment. The example of the ring fluid supply circuit which has a mixed injection port is shown. It is a figure explaining the example which connected the adapter of this invention to the mixed injection port of FIG. It is a figure explaining the example which connected the prefilled syringe of this invention to the side injection port of FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Prefilled syringe 11 Chemical solution storage part 12 Cylindrical protrusion wall part 13 Male screw part 15 Nozzle part 17 Step part 18 Restriction part 20 Adapter 21 Outer cylinder body 22 Inner cylinder body 23 Female screw part 24 1st chemical | medical solution channel | path 25 Hollow body part 26 Second chemical liquid passage 27 Needle-shaped shaft body 28 Long groove portion 29 Opening passage 30 Cap 40 Protective body

Claims (9)

A chemical storage part pre-filled with a chemical,
A nozzle part having a cylindrical protruding wall part that forms an opening for discharging the chemical liquid filled in the chemical liquid storage part, and a male screw part formed on the outer periphery of the cylindrical protruding wall part;
A prefilled syringe having a chemical solution discharge mechanism for discharging a chemical solution in the chemical solution storage portion, wherein the cylindrical protruding wall portion has an outer diameter of 4.3 mm to 5.4 mm. A chemical storage part pre-filled with a chemical,
A nozzle part having a cylindrical protruding wall part that forms an opening for discharging the chemical liquid filled in the chemical liquid storage part, and a male screw part formed on the outer periphery of the cylindrical protruding wall part;
A prefilled syringe having a chemical solution discharge mechanism for discharging the chemical solution in the chemical solution storage unit,
A step portion having an outer diameter larger than the outer diameter of the cylindrical projecting wall portion having the male screw portion is provided at the base portion of the nozzle portion.   The prefilled syringe according to claim 1 or 2, wherein a throttle portion having an opening diameter smaller than an inner diameter of the cylindrical protruding wall portion is provided on an inner peripheral side of the cylindrical protruding wall portion.   The prefilled syringe according to claim 2, wherein a throttle part having an opening diameter smaller than an inner diameter of the cylindrical projecting wall part is provided at a connection part between the step part and the cylindrical projecting wall part. To do.   5. The prefilled syringe according to claim 3, wherein an inner diameter of the cylindrical projecting wall portion is formed in a tapered shape that gradually decreases from the tip toward the throttle portion. An adapter connectable to the prefilled syringe according to any one of claims 1 to 5,
The adapter includes an outer cylinder body having an internal thread portion on an inner periphery thereof that is screwed into the external thread portion of the nozzle portion,
An inner cylinder that is in contact with the inner wall of the cylindrical projecting wall on the inner side of the outer cylinder and in which a first chemical liquid passage is formed;
A hollow body portion having a second chemical liquid passage that is communicated with the first chemical liquid passage of the inner cylinder and has one end closed;
A tapered needle-like shaft body having an opening passage that opens to the outer periphery of the second chemical liquid passage of the hollow body portion, and the outer cylinder body, the inner cylinder body, and the hollow body portion are integrally formed. It is characterized by.   The combination of the prefilled syringe and the adapter according to claim 6, wherein a distance from the tip of the needle-shaped shaft body to the opening passage is in a range of 15 to 30 mm.   The combination of the prefilled syringe and the adapter according to claim 6 or 7, wherein an end portion of the inner cylindrical body is formed to be retracted inward from an end portion of the outer cylindrical body. The prefilled syringe according to any one of claims 4 to 8, further comprising a cap that seals the nozzle portion of the prefilled syringe,
The cap includes a cap body having a contact portion on the inner surface that contacts and seals the outer periphery of the stepped portion, a first seal surface that contacts and seals the inner peripheral surface of the cylindrical protruding wall portion of the prefilled syringe, and And a projecting portion having a second sealing surface that contacts and seals the opening of the throttle portion.

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