JP2007167309A - Iontophoresis apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an iontophoresis apparatus capable of administering a large amount of a medicinal solution compared to an administered area when the area where the medicinal solution is administered is small. <P>SOLUTION: In the iontophoresis apparatus 10, a working-side electrode structure 20 is configured by stacking an annular medicinal solution retaining part 24, a second ion selective membrane 26, an electrolyte retaining part 28, and a working-side electrode 30 all of which sequentially enclose outside a first circular ion selective membrane 22 located at the center and by sealing with a working-side sealing material 32 with an exposing opening to expose the first ion exchange resin 22 part. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an iontophoresis device for administering drug ions to a living body.

  As described in Patent Document 1, the iontophoresis device as described above has a working electrode structure and a non-working electrode structure, and a chemical solution is applied to the skin and the ion exchange membrane of the working electrode structure. It penetrates the mucous membrane.

  The iontophoresis device as described above is intended for a relatively large area of skin or mucous membrane having a diameter of about 20 mm even when it is small, and injects a drug solution into a smaller part of the living body (pinpoint). In this case, a working electrode structure having a smaller diameter must be used.

  In this case, the area of the ion exchange membrane provided at the tip of the working electrode structure determines the chemical penetration area into the skin and mucous membrane, but both the working electrode structure and the non-working electrode structure were cut in advance. Since the same size ion exchange membrane, chemical solution holding part, electrolyte solution holding part, working electrode or non-working electrode are sequentially stacked, and the chemical liquid holding part has the same area as the chemical solution penetration area, it can be administered There is a problem that the amount of is limited by the area of the ion exchange membrane.

  Further, in the iontophoresis device described above, since the parts are sequentially stacked, there is a problem that the manufacturing process takes time.

WO03037425

  This invention makes it a solution subject to provide the iontophoresis apparatus which enabled it to administer sufficient chemical | medical solution even when the area which administers chemical | medical solution is small.

  It is another object of the present invention to provide an iontophoresis device that is easy to manufacture.

  That is, the above-described problems can be solved by the following embodiments.

  (1) A working electrode structure and a non-working electrode structure used to administer drug ions by iontophoresis, and these working electrode structures and non-working electrode structures have different polarities. The working electrode structure is electrically connected to the working electrode connected to the same kind of polarity as the drug ions in the direct current power supply. A drug solution holding unit that holds the drug ions, and at least the working electrode is annularly stacked so as to surround the drug solution holding unit as a center, At least one end surface in the direction orthogonal to the central axis of the chemical solution holding part in the range from the outer periphery of the chemical solution holding part to the working side electrode is sealed with an insulating working side sealing material. Iontophoresis device to.

  (2) The medicinal solution holding unit may impregnate the working ion selective membrane that selectively allows the same kind of ions as the drug ions to pass through or be applied to the ion selective membrane. The iontophoresis device according to (1), wherein the iontophoresis device is composed of any one of a mixture of a gel and a trace amount of gel.

  (3) A working ion-selective membrane that selectively passes ions opposite to the drug ions so as to surround the medicinal solution holding part between the medicinal solution holding part and the working electrode, and an electrolytic solution holding part And the iontophoresis device according to (1), wherein the iontophoresis device is provided in this order.

  (4) The working side sealing material seals one end face in the range from the outer periphery of the chemical solution holding part to the working side electrode, and the other end face in the range from the chemical solution holding part to the working side electrode. The iontophoresis device according to any one of (1) to (3), wherein the iontophoresis device comprises an insulating opposite-side action sealing material.

  (5) A working electrode structure and a non-working electrode structure used to administer drug ions by iontophoresis, and the working electrode structure and the non-working electrode structure with different polarities. The working electrode structure is electrically connected to the working electrode connected to the same kind of polarity as the drug ions in the direct current power supply. A drug solution holding unit that holds the drug ions, and a working ion selective membrane that is disposed in front of the drug solution holding unit and selectively allows the same kind of ions as the drug ions to pass through, The non-working side electrode structure includes an electrolysis which is electrically connected to the non-working side electrode connected to the polarity opposite to the drug ion in the DC power source and holds the electrolytic solution. Liquid retention And at least a non-working side ion selective membrane that is disposed on the front surface of the electrolyte solution holding portion and selectively passes ions opposite to the drug ions, and the working electrode structure is The medicinal solution holding part and the working electrode are arranged in this order in an annular manner so as to surround the working ion selective membrane as a center, and in the medicinal solution holding part and the working electrode. At least one end face in a direction orthogonal to the central axis of the working side ion selective membrane is sealed with an insulating working side sealing material.

  (6) The working-side sealing material includes a working sealing material that seals one end face in the range from the chemical solution holding unit to the working electrode, and the other in the range from the working-side ion-selective membrane to the chemical solution holding unit and the working electrode. An iontophoresis device according to (5), comprising: an insulating opposite-side action sealing material that seals an end face.

  (7) The non-working side electrode structure is formed by annularly laminating the electrolyte solution holding part and the non-working side electrode in this order so as to surround the non-working side ion selective membrane. And at least one end surface of the electrolyte solution holding part and the non-working side electrode in a direction perpendicular to the central axis of the non-working side ion selective membrane is sealed with an insulating non-working side sealing material. The iontophoresis device according to (5) or (6), wherein

  (8) The non-acting side sealing material includes a non-acting sealing material that seals one end face in a range from the electrolyte solution holding unit to the non-working side electrode, and an electrolyte solution holding unit and non-acting material from the non-working side ion selective membrane. The iontophoresis device according to (7), further comprising: an insulating opposite non-acting sealing material that seals an end face in the range of the side electrode.

  (9) When viewed from the direction orthogonal to the one end face, the working-side ion selective membrane and the non-working-side ion selective membrane are adjacent to each other via an insulating separation sealing material, and in a connected state, circular or The working ion-selective membrane is formed in a non-circular continuous shape, and the chemical solution holding unit and the electrolyte solution holding unit, and the working side electrode and the non-working side electrode are adjacent to each other and connected via a separation sealing material. The iontophoresis device according to (7) or (8), wherein an annular body is formed concentrically surrounding the non-working side ion selective membrane in this order.

  (10) The non-working side electrode structure includes the non-working side electrode surrounding the working side electrode via an insulating material and the electrolyte holding unit and the non-working side ion selective membrane so as to surround the non-working side electrode. In this order, the non-working side electrode and the end face continuous with the one end face of the electrolyte solution holding portion are sealed with the working side sealing material. The iontophoresis device according to 5) or (6).

  (11) The non-working side electrode structure includes the non-working side ion-selective membrane surrounding the working side electrode with an insulating material and the non-working side electrode structure. (5) or characterized in that the end faces continuous with the one end face of the electrolyte solution holding part and the non-working side electrode are sealed by the working side sealing material. The iontophoresis device according to (6).

  (12) The working sealing material and the non-working sealing material are continuously formed having exposed holes for exposing at least a part of the working-side ion selective membrane and the non-working-side ion selective membrane. The iontophoresis device according to any one of (5) to (11), wherein the iontophoresis device comprises a single sheet of sealing film.

  (13) Any one of (5) to (12), wherein a boundary surface between the working-side ion selective membrane and the chemical solution holding portion is a tapered surface that expands in the one end surface direction. An iontophoresis device described in 1.

  (14) The boundary surface between the non-working side ion selective membrane and the electrolytic solution holding part is a tapered surface that expands in the direction of the one end surface. (5) to (13) The iontophoresis device according to any one of the above.

  (15) The iontophoresis according to any one of (5) to (14), wherein the one end face side of the working side ion selective membrane protrudes from the working side sealing material. Cis equipment.

  (16) The working electrode structure is disposed on the working electrode, on the front surface of the working electrode, on the front surface of the electrolytic solution holding section, and on the front surface of the electrolytic solution holding section. A second ion-selective membrane that selectively allows ions opposite to drug ions to pass through; the drug solution holding portion disposed on the front surface of the second ion selective membrane; An iontophoresis device according to any one of (5) to (15), comprising a working side ion selective membrane.

  (17) Any two adjacent ones of the chemical solution holding unit, the second ion selective membrane, the electrolyte solution holding unit, and the working side electrode are arranged so as to overlap in the direction of the central axis of the working side ion selective membrane. The iontophoresis device according to (16), characterized in that:

  (18) The non-working side electrode structure includes the non-working side electrode, a second electrolytic solution holding unit that is disposed on the front surface of the non-working side electrode and holds the second electrolytic solution, and the second electrolytic solution. A third ion-selective membrane that is disposed in front of the holding unit and selectively allows the same kind of ions as the drug ions to pass through; a third electrolyte solution holding unit that is disposed in front of the third ion-selective membrane; The iontophoresis according to any one of (5) to (15), further comprising the non-working side ion selective membrane disposed on the front surface of the third electrolyte solution holding unit. apparatus.

  (19) Out of the third electrolyte solution holding unit, the third ion selective membrane, the second electrolyte solution holding unit, and the non-working side electrode, any two adjacent ones are arranged at the center of the non-working side ion selective membrane. The iontophoresis device according to (18), wherein the iontophoresis device is disposed so as to overlap in an axial direction.

  In the present invention, the working electrode structure is configured by laminating a chemical solution holding unit, another ion selective membrane, an electrolytic solution holding unit and the like sequentially in a ring shape with the working ion selective membrane as the center. Even if the contact area of the central working side ion selective membrane to the skin or the like is small, the chemical solution holding part or the like can be formed large.

  In the iontophoresis device according to the best mode, the working electrode structure is centered on the first ion selective membrane and surrounds the chemical solution holding portion, the second ion selective membrane, and the electrolyte solution holding. The working electrode and the working electrode are laminated in this order, and the non-working electrode structure is held by the third electrolyte so as to surround the fourth ion selective membrane. Part, the third ion selective membrane, the second electrolyte solution holding part, and the non-working side electrode are arranged in this order in an annular form, and the side of the working side electrode structure that contacts the human skin or the like Except for the first ion selective membrane portion, and the end surface on the contact side of the non-working side electrode structure to the human skin or the like is the fourth ion selective. A structure that is sealed by an insulating non-working side sealing material except for the membrane part Going on.

  Hereinafter, an iontophoresis device according to Embodiment 1 of the present invention will be described in detail with reference to FIGS.

  The iontophoresis device 10 according to the first embodiment includes a working electrode structure 20 and a non-working electrode structure 40 used to administer an ionic drug by iontophoresis, and the working side thereof. A DC power source 12 connected to the electrode structure 20 and the non-working side electrode structure 40 with different polarities.

  The working electrode structure 20 includes a chemical solution holding unit 24, a second ion selective membrane 26, an electrolyte solution holding unit 28, and a working electrode 30 so as to surround the first ion selective membrane 22. In this order, they are laminated in a ring shape.

  Further, the working electrode structure 20 has one end face 13A (the lower face in FIG. 1 and the contact surface to the human skin etc.) except for the portion of the first ion selective membrane 22, Sealed by an annular and insulating working side sealing material 32 having an exposed hole 32A in the center.

  The other end surface 13B opposite to the one end surface 13A of the working side electrode structure 20 is in contact with and supported by an insulating working side base sheet 34 and sealed.

  The working electrode 30 in the working electrode structure 20 is connected to the same kind of polarity as the drug ion in the DC power source 12, and is a conductive paint containing a nonmetallic conductive filler such as carbon paste, for example. It is composed of Although this working side electrode 30 can also be comprised with a copper plate or a metal thin film, since the metal eluted from this can transfer to a biological body at the time of chemical | medical agent administration, nonmetallic property is preferable.

  The electrolyte solution holding unit 28 holds an electrolyte, and the electrolyte is more easily oxidized or reduced than an electrolytic reaction of water (oxidation at the positive electrode and reduction at the negative electrode), for example, ascorbic acid. It is particularly preferable to use pharmaceutical agents such as (vitamin C) and sodium ascorbate, organic acids such as lactic acid, oxalic acid, malic acid, succinic acid, fumaric acid and / or salts thereof, whereby oxygen gas or hydrogen Generation | occurrence | production of gas can be suppressed and the fluctuation | variation of pH during electricity supply can also be suppressed by mix | blending multiple types of electrolyte of the combination used as buffer electrolyte solution when melt | dissolving in a solvent.

  The electrolytic solution holding unit 28 is a carrier made of any material having water retention properties such as a fiber sheet such as gauze or filter paper, or a polymer gel sheet such as a hydrogel of acrylic resin (acrylic hydrogel) or a segmented polyurethane gel. Is impregnated with or contained in an electrolyte solution. Moreover, what hold | maintains electrolyte solution in a liquid state may be used, and electrolyte paint may be used.

  Further, the second ion-selective membrane 26 that selectively passes ions opposite to the drug ions is disposed inside the electrolyte solution holding unit 28, and inside the second ion-selective membrane, A chemical solution holding unit 24 for holding the ionic drug is disposed.

  The second ion-selective membrane 26 contains an ion exchange resin into which an ion exchange group having a counter ion of a conductivity type opposite to the drug ions in the drug solution holding unit 24, which will be described later, is introduced, and the drug solution holding unit 28 When an agent that dissociates into a drug ion that becomes a cation becomes an anion exchange resin, and conversely, when an agent that dissociates into a drug ion that becomes an anion becomes an agent Cation exchange resin is blended.

  The medicinal solution holding part 24 contains a drug (including a drug precursor) in which the medicinal component is dissociated into positive or negative ions (drug ions) when dissolved in a solvent such as water. Examples of drugs that dissociate into positive ions include lidocaine hydrochloride, which is an anesthetic, and morphine hydrochloride, which is an anesthetic. Examples of drugs that dissociate into medicinal ions that have a medicinal component are ascorbic acid, which is a vitamin agent. Etc. can be illustrated.

  The chemical solution holding unit 24 is made of any material having water retention properties such as a fiber sheet such as gauze or filter paper, or a polymer gel sheet such as an acrylic resin hydrogel (acrylic hydrogel) or a segmented polyurethane gel. The carrier is constituted by impregnating or containing a drug solution. Moreover, you may use what hold | maintains a chemical | medical solution in a liquid state. In addition to the above, drugs include hormones, DNA, RNA, proteins, amino acids, and minerals.

  The first ion-selective membrane 22 is configured to select ions of the same type as the drug ions, and an ion exchange group having a counter ion of the same conductivity type as the drug ions in the drug solution holding unit 24 is introduced. In the case where a drug that dissociates into a cation or an anion is used as the medicinal component of the drug solution holding unit 24, this is a cation exchange resin or an anion exchange resin.

  Examples of the cation exchange resin include polymers having a three-dimensional network structure such as hydrocarbon resins such as polystyrene resins and acrylic resins, and fluorine resins having a perfluorocarbon skeleton, sulfonic acid groups, and carboxylic acids. An ion exchange resin into which a cation exchange group such as a group or a phosphonic acid group (an exchange group in which the counter ion is a cation) is introduced can be used without limitation.

  The anion exchange resin includes a polymer having the same three-dimensional network structure as the cation exchange resin, a primary to tertiary amino group, a quaternary ammonium group, a pyridyl group, an imidazole group, a quaternary group. An ion exchange resin into which an anion exchange group such as a pyridinium group or a quaternary imidazolium group (an exchange group in which the counter ion is an anion) is introduced can be used without limitation.

  The non-working side electrode structure 40 has a third electrolyte solution holding part 44, a third ion selective film 46, and a second electrolyte solution holding part 48 so as to surround the fourth ion selective film 42. The non-working side electrode 50 is formed by laminating in this order in an annular shape.

  The non-working side electrode 50 in the non-working side electrode structure 40 is connected to the polarity opposite to the charged ion of the drug ion in the DC power supply 12.

  The second electrolyte solution holding part 48 is disposed inside the non-working side electrode 50 and holds the second electrolyte solution.

  Further, the third ion selective membrane 46 is disposed inside the second electrolyte solution holding part 48 so as to selectively pass ions of the same kind as the charged ions of the drug ions.

  The third electrolyte solution holding unit 44 is disposed inside the third ion selective membrane 46 and holds the third electrolyte solution.

  The fourth ion selective membrane 42 is disposed inside the third electrolyte solution holding unit 44 and selectively allows ions opposite to the charged ions of the ionic drug to pass through.

  The non-working side electrode 50 has the same configuration as that of the working side electrode 30, and the configurations and components of the second electrolytic solution holding unit 48 and the third electrolytic solution holding unit 44 are the same as those of the electrolytic solution holding unit 28. It is the same.

  Further, the third ion selective membrane 46 functions as an ion selective membrane similar to the first ion selective membrane 22.

  The fourth ion selective membrane 42 is formed including the ion exchange resin contained in the second ion selective membrane 26 similar to the above. The fourth ion selective membrane 42 functions as an ion selective membrane equivalent to the second ion selective membrane 26.

  One end face 40A on the lower side of the non-working side electrode structure 40 in FIG. 1 is annular and insulative except for the portion of the fourth ion selective membrane 42 (exposed hole 52A). Sealed by the non-working side sealing material 52.

  Further, the other end face 40B opposite to the one end face 40A is entirely sealed by a non-acting side base sheet 54 (opposite side non-acting sealing material).

  As the DC power source 12, for example, a button battery or a thin battery disclosed in, for example, Japanese Patent Application Laid-Open No. 11-067236, US Patent Publication No. 2004 / 0185667A1, US Pat. No. 6,855,441, or the like can be used. The structure of the embodiment is not limited.

  The DC power source 12 is disposed integrally with the working side electrode structure 20 or the non-working side electrode structure 40, and the DC power source 12, the working side electrode structure 20, and the non-working side electrode structure 40 are connected to each other. They are connected by lead wires 14.

  Note that the end surface of the first ion selective film 22 on the one end surface 12A side is substantially flush with the outer surface of the working side sealing material 32, and similarly, the fourth ion selective film 42 is provided. The end face on the one end face 40A side is also configured to be substantially flush with the outer face of the non-acting side sealing material 52.

  Note that an adhesive layer 56 may be provided on the outer surfaces of the working side sealing material 32 and the non-working side sealing material 52 so as to adhere to the skin and mucous membrane of a living body. For the pressure-sensitive adhesive layer 56, for example, a silicon-based pressure-sensitive adhesive mainly composed of polyorganosiloxane, polyacrylic acid, polyacrylic acid salt, polymethacrylic acid, polyethacrylic acid salt, or the like is used.

  In the iontophoresis device 10 according to the first embodiment, the first ion selective membrane 22 of the chemical solution holding unit 24 with respect to the area of the end surface of the first ion selective membrane 22 that determines the administration area of the chemical solution. It is possible to administer a relatively large amount of a drug solution because it can be set large without being limited to the area in contact with.

  In addition, the working electrode structure 20 and the non-working electrode structure 40 both have an ion-selective membrane, an electrolyte solution holding portion, an electrode, and the like arranged in a ring shape like a trunk in a tree. It can be manufactured easily and in large quantities by making a long piece in a direction perpendicular to the circle.

  Next, an iontophoresis device 60 according to Embodiment 2 of the present invention will be described with reference to FIG.

  In this iontophoresis device 60, a portion corresponding to the first ion selective film in the working electrode structure 62 is divided into a thin first ion selective material film 22A on the one end face 13A side and the other side. The extension part 22 </ b> B, which is a part, is overlapped, and the extension part 22 </ b> B is extended from the chemical solution holding part 24.

  Further, in the non-working side electrode structure 64, the portion corresponding to the fourth ion selective membrane is divided into the film-like fourth ion selective material film 42A on the one end face 40A side, and the upper side in FIG. This part is composed of an extension part 42B from the third electrolyte solution holding part 44.

  In this iontophoresis device 60, an extension 24A is added to the chemical solution holding unit 24 and an extension 44A is added to the third electrolyte solution holding unit 44, respectively, to increase the amount of drug solution to be administered. be able to.

  Next, an iontophoresis device 70 according to Embodiment 3 shown in FIG. 4 will be described.

  In the working electrode structure 72 and the non-working electrode structure 74 in the iontophoresis device 70, the first ion-selective membrane 76 and the fourth ion-selective membrane 78 as the centers are provided on the skin or mucous membrane. The end surface (the other end surface) on the opposite side to the bonding surface is tapered so that the tip is tapered in the direction of 70B.

  Thereby, the distance to the skin or mucous membrane of the boundary surface between the chemical solution holding unit 79 and the first ion selective membrane 76 is made uniform, and the current during use is one of the first ion selective membranes 76. Concentration only on the outer peripheral portion on the end face 70A side can be suppressed.

  Next, a fourth embodiment of the present invention shown in FIG. 5 will be described.

  The iontophoresis device 80 according to the fourth embodiment is the same as the iontophoresis device 10 according to the first embodiment shown in FIGS. 1 and 2 in that the working electrode structure and the non-working electrode are circular in plan view. A state in which the working electrode structure 82 and the non-working electrode structure 84 having a semicircular shape in plan view, which are equivalent to the structure divided into two equal parts, are connected to each other through an insulating separation sealing material 86. Thus, it is configured to be circular in plan view.

  Therefore, in this iontophoresis device 80, the semicircular chemical liquid holding part 24A and the third electrolyte holding part 44A both form the first annular body 88, and the second ion selective membrane 26A and the third ion selective. 46A is the second annular body 90, the electrolytic solution holding part 28A and the second electrolytic solution holding part 48A are the third annular body 92, and the working electrode 30A and the non-working side electrode 50A are the fourth annular body. 94, respectively, via a separation sealing material 86, and these are formed in a central circle composed of the first ion selective membrane 22A and the fourth ion selective membrane 42A that are semicircular in plan view. In this order, they are concentrically enclosed.

  In this iontophoresis device 80, first, a circular working electrode structure and a non-working electrode structure are formed in a plan view, and then divided into two along a diameter line to form a semicircular shape. The working-side electrode structure 82 and the non-working-side electrode structure 84 may be formed, and these may be connected so as to form a circle via the separation sealing material 86.

  Next, an iontophoresis device 100 according to Embodiment 5 of the present invention shown in FIG. 6 will be described.

  In the iontophoresis device 100, the first ion selective membrane 22 and the fourth ion selective membrane 42 in the iontophoresis device 10 shown in FIG. 1 and FIG. In contrast, the central portions of the first ion selective film 106 and the fourth ion selective film 108 at the centers of the working electrode structure 102 and the non-working electrode structure 104 are the working seal material. 32 and the non-working side sealing material 52, and taper protrusions 106A and 108A tapering in the protruding direction are formed.

  Since other configurations are the same as those in the iontophoresis device 10, the same components as those in the first embodiment are denoted by the same reference numerals, and description thereof is omitted.

  In the iontophoresis device 100 according to the fifth embodiment, for example, when the chemical solution is introduced from the mucous membrane of the pierced part formed on the earlobe, it is convenient when the chemical solution is introduced to the pinpoint of the living body.

  Next, an iontophoresis device 110 according to Embodiment 6 of the present invention shown in FIG. 7 will be described.

  The iontophoresis device 110 is arranged outside the working electrode structure 20 in the iontophoresis device 10 shown in FIGS. 1 and 2 so as to surround the working electrode structure 20 concentrically. Is formed.

  A non-working side electrode 50 is provided adjacent to the outside of the working side electrode 30 via an insulating material 112. That is, the non-working side electrode structure 120 is arranged in the order opposite to that of the first embodiment from the non-working side electrode 50 to the fourth ion selective membrane 42.

  Since other configurations are the same as those in the iontophoresis device 10, the same components as those in the first embodiment are denoted by the same reference numerals, and the description thereof is omitted.

  Next, an iontophoresis device 120 according to Embodiment 7 of the present invention shown in FIG. 8 will be described.

  The working electrode structure 122 of the iontophoresis device 120 has a first ion-selective membrane 126, a chemical solution replenishment layer 128, an inner liner 130, and a second ion-selective membrane on the outer periphery of the chemical solution holding part 124. 132, the electrolytic solution holding part 134, and the working side electrode 136 are sequentially laminated in a ring shape.

  The ion selective membrane 126, the second ion selective membrane 132, the electrolytic solution holding part 134, and the working electrode 136 are the first ion selective membrane 22, the second ion selective membrane 26, and the electrolytic solution in the first embodiment. Since it is the same structure as the holding | maintenance part 28 and the action | operation side electrode 30, description is abbreviate | omitted.

  The drug solution holding part 124 is applied with the same drug ions as used in the drug solution holding part 24 in the first embodiment. The chemical solution replenishment layer 128 is composed of similar drug ions.

  The inner liner 130 is made of release paper or a release film, and prevents the chemical solution replenishment layer 128 and the second ion selective membrane 132 from coming into contact with each other. This prevents mixing of the drug and drug solution replenishment layer 128 due to diffusion of drug ions.

  Since the inner liner 130 is not sticky to the second ion-selective membrane 132, no release agent is required on the side in contact with the second ion-selective membrane 132. Therefore, the inner liner 130 may be a waterproof thin film.

  The lower end face in FIG. 8 of the working side electrode structure 122 is outside the chemical solution holding part 124, that is, in the range from the first ion selective membrane 126 to the working side electrode 136. Is sealed by.

  The portion of the action sealing material 138 corresponding to the chemical solution holding portion 124 is an exposed hole 139, and the tip of the chemical solution holding portion 124 exposed from the exposed hole 139 is formed by a central liner 140 that can be easily peeled off. It is sealed.

  In addition, the end surface of the working side electrode structure 122 opposite to the working sealing material 138, that is, the entire range from the chemical solution holding part 124 to the outermost working side electrode 136 is a sheet serving as a working side base sheet. These are sealed by an insulating opposite-side action sealing material 142.

  Further, the inner liner 130 is housed in two between the chemical solution replenishment layer 128 and the second ion selective membrane 132, and one end 130A of the working electrode structure 122 is shown in FIG. The inner liner 130 can be pulled out from between the chemical solution replenishment layer 128 and the second ion selective membrane 132 by being pulled upward.

  An end portion 130 </ b> A of the inner liner 130 that protrudes to the outside protrudes through the opposite-side action sealing material 142.

  The description of the configuration of the non-working side electrode structure 123 is omitted.

  When the iontophoresis device 120 according to this embodiment is used, the central liner 140 is peeled off to expose the chemical solution holding part 124, and the inner liner 130 is pulled by pulling the end part 130A from the outside. Then, the chemical solution replenishment layer 128 and the second ion selective membrane 132 are pulled out and brought into contact with each other. As a result, ions different from the drug ions can be moved from the chemical solution replenishment layer 128 through the second ion selective membrane 132 to the electrolyte solution holding unit 134.

  In addition, although the said chemical | medical solution holding | maintenance part 124 is comprised from the drug ion apply | coated to the 1st ion selective membrane 126, this invention is not limited to this, For example, the said 1st ion selective membrane 126 may be impregnated with drug ions, or a mixture of drug ions and a small amount of gel may be provided outside the first ion selective membrane 126.

  According to each of the above embodiments, even when the contact area between the first ion-selective membrane or the drug solution holding part 124 and the skin is small, that is, even when the administration area is small, the drug solution holding part is formed to be thick. The dose per area can be increased.

  In addition, when a chemical layer or the like is laminated on the ion selective membrane in the thickness direction as in the prior art, the thickness is inevitably increased and flexibility is lost. However, in the configuration of each of the above embodiments, the working electrode structure and / or Alternatively, the non-working side electrode structure can be thinned, and thus there is an effect that the skin followability during use is improved.

  Further, in each of the above embodiments, the width between the layers can be freely selected. For example, the electrode solution and the drug ions are mixed by widening the width of the ion selective membrane such as the ion selective membrane. You can avoid it.

  Furthermore, according to each of the above embodiments, if each layer is formed in an annual ring shape in the trunk of the tree around the chemical solution holding part or the first ion selective membrane in the center, It can be manufactured at low cost.

  For example, in the case of a working electrode structure, the working electrode, the electrolyte solution holding unit, the second ion selective membrane, the chemical solution holding unit, and the first ion selective membrane are applied in this order on the base sheet. After sequentially forming by sticking, printing, spraying, etc., the whole is formed in an annual ring shape, that is, in a roll shape, and then this is cut into rings, for example, the working side electrode as shown in FIG. A structure can be obtained.

  In Examples 1 to 6, the working electrode structure is formed from the first ion selective membrane, the chemical solution holding unit, the second ion selective membrane, the electrolytic solution holding unit, and the working electrode, The non-working side electrode structure is composed of a fourth ion-selective membrane, a third electrolyte solution holding unit, a third ion-selective membrane, a second electrolyte solution holding unit, and a non-working side electrode. However, the working electrode structure may be composed of a chemical solution holding part and a working electrode, or may be composed of a first ion selective membrane, a chemical solution holding part, and a working electrode. It may be what you did.

  Further, in each of the above embodiments, each layer constituting the working electrode structure or the non-working electrode structure is formed by sequentially laminating the ring from the center side, but the present invention is limited to this. The shape in plan view may be a quadrangle, a hexagon, a long side, or the like.

  Furthermore, in the non-working side electrode structure between the central first ion selective membrane and the outermost working side electrode, or between the chemical solution holding part and the working side electrode, the fourth ion selective membrane and the non-working side electrode structure. A plurality of layers between the working side electrodes may be partially laminated in the thickness direction, for example, like the iontophoresis device 150 or 160 shown in FIG. 9 or FIG.

  The iontophoresis device 150 includes a working electrode structure 152 and a non-working electrode structure 154, and the iontophoresis device 160 includes a working electrode structure 162 and a non-working electrode structure 164. ing. 9 and 10, the same parts as those of the first embodiment are denoted by the same reference numerals and the description thereof is omitted.

  In these cases, in order to make the electrical contact order the same as in each of the above embodiments, a sealing material 144 is provided on the side surface so as not to be short-circuited.

  The first ion selective membrane is composed of a membrane containing an ion exchange resin. However, the present invention is not limited to this, and an ion selective membrane having a function of selecting target ions. I just need it.

Sectional drawing which shows the iontophoresis apparatus which concerns on Example 1 of this invention. Plan view Sectional drawing similar to FIG. 1 which shows the iontophoresis apparatus based on Example 2 of this invention. Sectional drawing similar to FIG. 1 which shows the iontophoresis apparatus based on Example 3 of this invention. Plan view showing an iontophoresis device according to Embodiment 4 of the present invention. Sectional drawing similar to FIG. 1 which shows the iontophoresis apparatus based on Example 5 of this invention. The top view similar to FIG. 2 which shows the iontophoresis apparatus based on Example 6 of this invention. Sectional drawing similar to FIG. 1 which shows the iontophoresis apparatus based on Example 7 of this invention. Sectional drawing which shows typically the modification of the lamination | stacking method of the intermediate | middle layer in a working electrode structure or a non-working electrode structure Sectional drawing which shows the other modification schematically

Explanation of symbols

10, 60, 70, 80, 100, 110, 120, 150, 160 ... iontophoresis device 12 ... DC power supply 13A, 40A, 70A ... one end face 20, 62, 72, 82, 102, 122, 152, 162 ... Working side electrode structure 22, 22A, 62, 76, 103, 126 ... First ion selective membrane 24, 24A, 79, 124 ... Chemical solution holding part 26, 26A, 132 ... Second ion selective membrane 28, 28A, 134 ... Electrolyte holding part 30, 30A, 136 ... Working side electrode 32 ... Working side sealing material 34 ... Working side base sheet (opposite side working sealing material)
40, 64, 74, 84, 104, 120, 154, 164 ... non-working side electrode structure 13B, 40B, 70B ... other end face 42, 42A, 64, 78, 105 ... fourth ion selective membrane 44, 44A ... 3rd electrolyte solution holding part 22A, 42A ... Extension part 46, 46A ... 3rd ion selective membrane 48, 48A ... 2nd electrolyte solution holding part 50, 50A ... Non-action side electrode 52 ... Non-action side sealing material 54 ... Non-operating side base sheet (opposite non-acting sealing material)
56 ... Adhesive layer 82A, 84A ... Tapered protrusion 86 ... Separation seal material 88 ... First annular body 90 ... Second annular body 92 ... Third annular body 106A, 108A ... Tapered protrusion 112 ... Insulating material 130 ... Inner liner 138 ... Action sealing material 142 ... Opposite side action sealing material 144 ... Sealing material

Claims (19)

Working and non-working electrode structures used to administer drug ions by iontophoresis and are connected to these working and non-working electrode structures with different polarities DC power supply,
The working electrode structure includes a working electrode connected to the same kind of polarity as the drug ion in the DC power supply, and a drug solution holding unit electrically connected to the working electrode and holding the drug ion. And at least the working electrode is annularly stacked so as to surround the medicinal solution holding part, and the working electrode is disposed from the outer periphery of the medicinal solution holding part. The iontophoresis device according to claim 1, wherein at least one end face in a direction perpendicular to the central axis of the chemical solution holding portion is sealed with an insulating working side sealing material. In claim 1,
The medicinal solution holding unit impregnates the drug ion on the working side ion selective membrane that selectively allows the same kind of ions as the drug ions to pass through or is applied to the ion selective membrane. An iontophoresis device comprising any one of a mixture with a gel agent. In claim 1,
Between the drug solution holding unit and the working electrode, a working ion selective membrane that selectively passes ions opposite to the drug ions so as to surround the drug solution holding unit, and an electrolyte solution holding unit, An iontophoresis device characterized by being provided in this order. In any one of Claims 1 thru | or 3,
The working-side electrode-side sealing material seals one end face in the range from the outer periphery of the chemical solution holding part to the working side electrode, and the other end face in the range from the chemical solution holding part to the working-side electrode. An iontophoresis device comprising: an insulating opposite-side action sealing material. Working and non-working electrode structures used to administer drug ions by iontophoresis and are connected to these working and non-working electrode structures with different polarities DC power supply,
The working electrode structure includes a working electrode connected to the same kind of polarity as the drug ion in the DC power supply, and a drug solution holding unit electrically connected to the working electrode and holding the drug ion. , At least a working side ion-selective membrane that is disposed in front of the drug solution holding section and selectively allows the same kind of ions as the drug ions to pass therethrough,
The non-working side electrode structure includes a non-working side electrode connected to a polarity opposite to that of the drug ion in the DC power source, and an electrolytic solution that is electrically connected to the non-working side electrode and holds the electrolytic solution A holding unit and a non-working side ion selective membrane that is disposed on the front surface of the electrolyte solution holding unit and selectively allows ions opposite to the drug ions to pass therethrough,
The working-side electrode structure is configured by laminating the drug solution holding portion and the working-side electrode in this order in an annular manner so as to surround the working-side ion selective membrane. Iontophoresis characterized in that at least one end face in a direction perpendicular to the central axis of the working side ion selective membrane in the chemical solution holding part and the working side electrode is sealed with an insulating working side sealing material. apparatus. In claim 5,
The working side sealing material seals one end face in the range from the chemical solution holding part to the working side electrode, and the other end face in the range from the working side ion selective membrane to the chemical solution holding part and the working side electrode. An iontophoresis device comprising an insulating opposite-side action sealing material. In claim 5 or 6,
In the non-working side electrode structure, the electrolyte solution holding part and the non-working side electrode are arranged in an annular form in this order so as to surround the non-working side ion selective membrane. And at least one end surface of the electrolyte solution holding part and the non-working side electrode in the direction perpendicular to the central axis of the non-working side ion selective membrane is sealed with an insulating non-working side sealing material. An iontophoresis device characterized by that. In claim 7,
The non-working side sealing material includes a non-working sealing material that seals one end face in a range from the electrolyte solution holding unit to the non-working side electrode, and a non-working side ion-selective membrane from the electrolyte holding unit and the non-working side electrode An iontophoresis device comprising: an insulating non-acting sealing material that seals an end face of the region. In claim 7 or 8,
When viewed from a direction orthogonal to the one end surface, the working ion selective membrane and the non-working ion selective membrane are adjacent to each other via an insulating separation sealing material, and are connected in a circular or non-circular shape. It is a continuum shape,
The chemical solution holding part and the electrolyte solution holding part, and the working side electrode and the non-working side electrode are adjacent to each other via a separation sealing material, and the working side ion selective membrane and the non-working side ion selective membrane are connected. An iontophoresis device characterized by forming an annular body concentrically surrounding in this order. In claim 5 or 6,
The non-working side electrode structure includes the non-working side electrode surrounding the working side electrode via an insulating material and the electrolyte solution holding unit and the non-working side ion selective membrane so as to surround the non-working side electrode. An iontophoresis characterized in that the non-working side electrode and the end face continuous with the one end face of the electrolyte solution holding portion are sealed by the working side sealing material. apparatus. In claim 5 or 6,
The non-working side electrode structure is formed by laminating the non-working side ion-selective membrane surrounding the working side electrode with an insulating material and the electrolyte solution holding unit and the non-working side electrode in this order so as to surround the non-working side ion selective membrane. An iontophoresis device characterized in that an end surface continuous with the one end surface of the electrolyte solution holding part and the non-working side electrode is sealed by the working side sealing material. In any of claims 5 to 11,
The working sealing material and the non-working sealing material are one continuous piece having exposed holes for exposing at least a part of the working-side ion selective membrane and the non-working-side ion selective membrane. An iontophoresis device characterized by comprising a sealing film. In any of claims 5 to 12,
An iontophoresis device characterized in that a boundary surface between the working side ion selective membrane and the chemical solution holding part is a tapered surface that expands in the direction of the one end surface. In any of claims 5 to 13,
An iontophoresis device characterized in that a boundary surface between the non-working side ion selective membrane and the electrolyte solution holding portion is a tapered surface that expands in the one end surface direction. In any of claims 5 to 14,
In the iontophoresis device, the one end face side of the working side ion selective membrane protrudes from the working side sealing material. In any of claims 5 to 15,
The working electrode structure is disposed on the front surface of the working electrode, the front surface of the working electrode, and holds an electrolytic solution, and is disposed on the front surface of the electrolytic solution holding portion, and the drug ions A second ion-selective membrane that selectively allows opposite ions to pass through; the chemical solution holding portion disposed in front of the second ion selective membrane; and the working ion disposed in front of the chemical solution holding portion. An iontophoresis device comprising: a selective membrane. In claim 16,
Any two adjacent ones of the chemical solution holding unit, the second ion selective membrane, the electrolyte solution holding unit, and the working side electrode are arranged so as to overlap each other in the direction of the central axis of the working side ion selective membrane. An iontophoresis device. In any of claims 5 to 15,
The non-working side electrode structure includes the non-working side electrode, a second electrolytic solution holding unit that is disposed in front of the non-working side electrode, and holds the second electrolytic solution, and the second electrolytic solution holding unit A third ion-selective membrane that is disposed on the front surface and selectively allows ions of the same kind as the drug ions to pass therethrough; a third electrolyte solution holding unit that is disposed on the front surface of the third ion-selective membrane; An iontophoresis device comprising: the non-working side ion selective membrane disposed on the front surface of the electrolyte solution holding unit. In claim 18,
Of the third electrolyte solution holding part, the third ion selective membrane, the second electrolyte solution holding part, and the non-working side electrode, any two adjacent ones are arranged in the direction of the central axis of the non-working side ion selective film. An iontophoresis device characterized by being placed on top of each other.

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