JP2007106719A - Stress reducing composition using component derived from newborn baby - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a smell for reducing stress, particularly a general malaise characteristic of women, that is, unpleasant symptoms after childbirth. <P>SOLUTION: As a result of a diligent study in order to solve the above problem, it has been found that the smell of a newborn baby positively acts on a feeling relating to a depressive mood, a feeling of fatigue or the like of a test subject [for example, a woman after childbirth (who is having maternity blues at this time)]. Thus, based on this knowledge, a composition for reducing stress comprising a component derived from a newborn baby is provided. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a novel use of a newborn-derived component. More specifically, the present invention relates to a composition for improving discomfort after childbirth, which uses the smell of a newborn as an active ingredient, and a method for improving the discomfort. Discomfort caused by maternity blues can be improved by the composition or method of the present invention.

  Women have indefinite complaints (depressed mood, malaise, decreased motivation, sleep disturbance) immediately after giving birth (2 weeks from the 3rd to 5th day after giving birth). The indefinite complaint is seen in 80% of women and is called maternity blues.

  Until now, maternity blues has been treated with hormone replacement therapy in severe cases, but in mild cases it is breastfeeding, so it has been excluded from medical care and women have been forced to change.

  Recently, aromatherapy has been performed as an alternative medicine, but there is also a preference for scents and it has not been accepted by all mothers. However, when olfactory information is input directly to the limbic system, which is the center of emotion, and to the hypothalamus, which is the center of instinct (feeding, sleep) hormone, without passing through the cerebral neocortex, There is a possibility that it can be developed as a new central nervous system drug without transvenous or transdermal route.

Non-patent document 1 outlines communication through body odor in humans. However, there is no story about stress improvement.
Shinohara Kazuyuki, Morobushi Masayo, Takahashi Toshiya, Mitsuda Univ., Takashi Hisako, Communication through body odor in humans, Journal of Taste and Odor Society, 7, 11-17 (2000).

  An object of the present invention is to provide an odor that improves stress, in particular, indefinite complaints peculiar to women, that is, discomfort after childbirth.

  As a result of intensive studies to solve the above problems, the present inventor has found that the odor of the newborn is depressed in the subject (for example, a woman after giving birth (causing maternity blues at this time)), malaise, etc. Based on this finding, the present inventors have completed the present invention.

Accordingly, the present invention provides the following.
(1) A composition for improving stress, comprising a component derived from a newborn.
(2) The composition according to item 1, wherein the component is an odor component.
(3) The composition according to item 1, wherein the stress is female stress.
(4) The composition according to item 1, wherein the stress is after the birth of a woman.
(5) The composition according to item 1, wherein the stress is an unpleasant symptom after delivery of a woman.
(6) The composition according to item 1, wherein the component is derived from sweat of the newborn.
(7) The composition according to item 1, wherein the newborn is one month or less after birth.
(8) The composition according to item 1, wherein the newborn is within one week after birth (for example, 0 to 4 days of age).
(9) The composition according to item 1, wherein the component is recovered from the underwear after the newborn is put on the underwear and continued to be worn for 8 to 24 hours.
(10) The composition according to item 1, wherein the stress is measured by a psychological test item selected from the group consisting of happiness, friendliness, pleasure, anxiety, motivation, fatigue, and motherhood.
(11) The composition according to item 1, wherein the stress is measured by a psychological test item selected from the group consisting of happiness, familiarity, anxiety, fatigue, and motherhood.
(12) The composition according to item 1, wherein the stress is measured by a psychological test item selected from the group consisting of pleasure and motivation, and the newborn is the female child.
(13) The composition according to item 1, wherein the stress is caused by maternity blues.
(14) A method for improving stress, comprising a step of administering a component derived from a newborn.
(15) The method according to item 14, wherein the component is an odor component.
(16) The method according to item 14, wherein the stress is female stress.
(17) The method according to item 14, wherein the stress is after childbirth.
(18) The method according to item 14, wherein the stress is an unpleasant symptom after delivery.
(19) The method according to item 14, further comprising a step of extracting a component derived from sweat of a newborn as the component.
(20) The method according to item 14, wherein the newborn is one month or less after birth.
(21) The method according to item 14, wherein the newborn is within one week after birth (for example, 0 to 4 days of age).
(22) The method according to item 14, further comprising a step of recovering the component from the underwear after the underwear has been put on the newborn and continued to be worn for 8 to 24 hours.
(23) The method according to item 14, wherein the stress is measured by a psychological test item selected from the group consisting of happiness, friendliness, pleasure, anxiety, motivation, fatigue, and motherhood.
(24) The method according to item 14, wherein the stress is measured by a psychological test item selected from the group consisting of happiness, familiarity, anxiety, fatigue, and motherhood.
(25) The method according to item 14, wherein the stress is measured by a psychological test item selected from a group consisting of pleasantness and motivation, and the newborn is the female child.
(26) A method according to item 14, wherein the stress is caused by maternity blues.
(27) A device for stress improvement comprising a part containing a component derived from a newborn.
(28) The device according to item 27, wherein the component has the characteristics according to any one of items 2 to 13.
(29) The device according to item 27, wherein the means for administering the odor of the newborn is a means for transmitting stimulation by the odor of the newborn to the brain via the olfactory nerve.
(30) The device according to item 27, wherein the means by which stimulation by the smell of the newborn is transmitted to the brain via the olfactory nerve is means for causing the subject to smell the air containing the smell of the newborn.
(31) The apparatus according to any one of items 27 to 30, wherein the stress is an unpleasant symptom after delivery.
(32) The apparatus according to any one of items 27 to 30, wherein the stress is caused by maternity blues, which is a discomfort after childbirth.
(33) Use of a component derived from a newborn in the manufacture of a medicament for improving stress.

  Preferred embodiments of the present invention will be shown below, but those skilled in the art can appropriately implement the embodiments and the like from the description of the present invention and well-known and common techniques in the field, and the effects and effects of the present invention can be easily achieved. It should be recognized to understand.

  The present invention has the unexpected effect of improving stress, particularly the stress state of women (preferably women after childbirth). Since the composition of the present invention can improve discomfort after childbirth, it is useful as an remedy for maternity blues and the like. In addition, since the composition of the present invention can be administered by a method via the olfactory nerve, it can exert its effect in a short time, and since it does not involve blood, it has the advantage of having no side effects on the liver and kidney.

  The invention will now be described by way of example, with reference to the accompanying drawings, where appropriate. Throughout this specification, it should be understood that the singular forms also include the plural concept unless specifically stated otherwise. Therefore, it should be understood that the expression of the singular includes the concept of the plural unless specifically stated otherwise. In addition, it is to be understood that the terms used in the present specification are used in the meaning normally used in the art unless otherwise specified. Thus, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

(Definition)
Listed below are definitions of terms particularly used in the present specification.

  As used herein, the term “human newborn” has the meaning normally used and means an individual within one month after delivery. Preferably, the newborn can be an individual within one week of life (eg, 0-4 days old). Premature infants are used in the same meaning as commonly used, and mean newborns whose birth weight is 2.5 kg or less.

  In the present specification, “a component derived from a newborn” or “a component derived from a newborn” refers to any component obtained from a newborn. It can be obtained by any method of the component derived from a newborn, and in particular, it is recovered from the underwear after the newborn is put on the underwear and continued to be worn for 8 to 24 hours. In addition to this, the neonate-derived component can be obtained, for example, by the following method: a method of collecting by putting on, laying or sticking underwear, cloth, towels, etc .; How to collect with a shirt.

  Thus, neonatal-derived components include odor components and substances that may not be perceived by the olfactory sense but can be perceived by the newborn in some form.

  As used herein, “stress” refers to a functional change that occurs in the mind and body when various external stimuli act as a burden, and usually the internal environment's homeostasis can be distorted by factors from the outside or inside. Refers to the state. Stress-causing elements (stressors) include physicochemicals such as cold / noise / chemical substances, biological things such as hunger / infection / overwork / insufficient sleep, social tension / anxiety / fear / excitement There are various things such as things, and they may be classified according to their causes. As used herein, stress can be classified as “pain stress”, “anxiety stress”, “fear stress”, “maladjustment stress”, “loss stress”, “loss of health stress”, “loss of self-esteem stress”, and the like. . Stress can be determined by measuring body movements for 60 seconds in the actogram of pain during blood collection, or by the rate of crying or frowning over a period of time (eg, 1 minute). In addition, it has been proved that the actigram, the frown face, and the cry are correlated with each other. Maladaptive stress refers to stress caused by maladjustment to a new situation, and can include stress due to marriage, pregnancy, childbirth, birth of siblings, relocation, admission, admission, employment, retirement, job change, etc. Loss stress refers to stress caused by loss of support, and can include stress due to divorce, separation from family, bereavement of relatives or close relatives, and the like. Loss of health stress refers to stress caused by loss of physical health, and can include injury, removal of an organ by surgery, long-term hospitalization, and the like. Self-esteem loss stress refers to stress caused by loss of self-esteem, and can include unemployment, dismissal, relegation, bankruptcy, conviction, and so on. In this specification, it is measured by a psychological examination item selected from the group consisting of happiness, friendliness, pleasure, anxiety, motivation, fatigue, and motherhood. These psychological test items can be measured by using the POMS (Profile Of Mood State) revised version VAS (Visual Analog Scale). As used herein, stress is specifically targeted to female stress. In the present invention, stress can be particularly targeted after a woman's childbirth, and in a preferred embodiment can be a deep symptom after a woman's childbirth.

  In the present specification, happiness is a psychological factor of pleasant emotion caused by joy, love, self-confidence, sense of accomplishment, etc., and can be measured as follows. Measure by using POMS revised VAS. Happiness is on the 10 cm line (VAS), the middle is 0 point, one end “feels happy (+5 points)”, the other end “feels unhappy (−5 points)” It is measured by having the subject fill in which part of the line corresponds to his / her feelings.

  In the present specification, the familiarity is a psychological factor of feelings that want to behave socially, and can be measured as follows. Measure by using POMS revised VAS. The familiarity is defined on the 10 cm line (VAS) as the middle is 0 point, one end is “feeling familiarity (+5 points)” and the other end is “not feeling familiarity (−5 points)” The test is performed by having the test subject fill in which part of his / her feeling corresponds to that line.

  In this specification, pleasant is a psychological factor called emotion that is a motivation for selecting a food or environment necessary for maintaining the life of an individual, and can be measured as follows. Measure by using POMS revised VAS. Pleasure is defined on the 10 cm line (VAS) as 0 in the middle, “feel comfortable (+5 points)” on one end, and “feel uncomfortable (−5 points)” on the other end. Measures by asking you to fill in what part of your line corresponds to your feelings.

  In this specification, anxiety is the feeling opposite to relaxation. When an individual's “holding / survival” is threatened, the “holding / improvement” of the position is compromised, “an unknown matter / situation” Is a psychological factor of emotions that occur when faced with, and can be measured as follows. Measure by using POMS revised VAS. Anxiety is defined as 10 points on the 10 cm line (VAS), with 0 in the middle, “I feel anxiety (+5 points)” on one end, and “I feel secure (−5 points)” on the other end. The test is performed by having the test subject fill in which part of his / her feeling corresponds to that line.

  In this specification, motivation is a psychological factor called emotion when there is motivation and can be measured as follows. Measure by using POMS revised VAS. Motivation is defined on the 10cm line (VAS) as the middle is 0 point, one end is "motivated (+5 points)" and the other end is "motivated (-5 points)" Measure by asking the subject to fill in what part of the line corresponds to their feelings.

  In the present specification, fatigue is an emotion associated with fatigue, laziness, and weakness, and is a psychological factor called emotion that is also referred to as fatigue, and can be measured as follows. Measure by using POMS revised VAS. Fatigue is defined as 10 points on the 10 cm line (VAS), the middle is 0 point, one end is “feeling tired (+5 points)”, and the other end is “were tired (−5 points)” Measure by asking the subject to fill in what part of the line corresponds to their feelings.

  In this specification, maternity is an emotion that makes children feel loved. Or it is a psychological factor called emotion that arises in response to increased interest in children, and can be measured as follows. Measure by using POMS revised VAS. The motherhood is on the 10 cm line (VAS), the middle is 0 point, one end is “children ’s dear (+5 points)”, the other end is “not interested in children (−5 points)” Defined and measured by having the subject fill in what part of the line corresponds to his / her feelings.

  As used herein, “odor component” refers to any substance or component that is sensed by smell. An olfactory substance is characterized by volatility and diffuses in a medium (for example, air or water) as so-called odorous particles to reach the olfactory receptor.

  In the present specification, the “component derived from sweat” refers to any component that can be directly or indirectly obtained from sweat itself and sweat.

  In the present specification, “immediately after giving birth” has a meaning usually used, and usually means within one week after birth, preferably within three days.

  As used herein, “maternity blues” refers to a symptom in a woman immediately after giving birth. Maternity blues symptoms include insomnia, irritability, tearfulness, depression, anxiety, and poor concentration, and usually begins 3-5 days after delivery and disappears within 2 weeks. In the past, treatment with hormone replacement therapy was used in severe cases, but in the case of mild cases, breastfeeding was excluded from medical treatment, and women were forced to change.

  As used herein, “same species” refers to the same species when referring to animals. The same species includes allogeneic and homologous. It is preferable that the component contained in the composition of this invention is the same kind as the test subject (for example, woman).

  The "animal species" referred to in this specification are Group I: African beasts (long legs, African shrews, caninees, close hoofs, rocks, long nose, sea cows), Group II: Heterogeneous (heterogeneous, Boreoyuteria), GroupIII: True lords (primary rodents) (True lords, climbers, wings, primates, Griles) , Heavy teeth, rodents), Group IV: Laurasian beasts (Cannitic, Winged, Hoofed, Strangely, and Lepidoptera). Preferably, the animal species is a species belonging to the primate, more preferably the animal species can be human.

  In this specification, “freeze drying” refers to an operation of sublimating and drying moisture in a vacuum at low temperature. Herein, it can be lyophilized using any method known in the art. Freeze the aqueous solution and dry it by sublimating moisture directly in a frozen state with a vacuum chamber. Also called freeze drying. This is a special case of vacuum drying. It is used for drying substances that are unstable to heat and easily change when left as an aqueous solution, or substances that are difficult to concentrate under reduced pressure due to foaming or the like, and animal and plant tissues. It was unexpected that the active ingredient of the present invention was resistant to lyophilization.

  In the present specification, “spraying” is used in the same meaning as commonly used, and refers to a process of making a fluid (eg, liquid) into a mist.

  In the present specification, feed, food and medicine are used in the same meaning as commonly used.

  In the present specification, “exposure” refers to an action in a state sufficient for the interaction of the component of the present invention and the target to be acted on.

  The active ingredient of the present invention can be used as it is, but an ingredient isolated by extraction or the like may be used.

  As used herein, “isolated” means that the substances naturally associated with it in a normal environment are at least reduced, preferably substantially free. “Isolated” when referring to a component (eg, small molecule, nucleic acid or polypeptide) is substantially free of chemicals or culture media, eg, when made by recombinant DNA technology, When synthesized, refers to small molecules, nucleic acids or polypeptides that are substantially free of precursor chemicals or other chemicals.

  In the present invention, the collected fraction can be lyophilized according to a known lyophilization method to obtain a powdered neonatal component.

  As used herein, “underwear” refers to clothing made of any material that can be worn by a newborn and can adsorb components derived from the newborn (eg, odor components and sweat). Examples of the material include, but are not limited to, cotton (gauze, absorbent cotton), hemp, synthetic fiber (polyester, etc.) and silk.

  The extracted active ingredient of the present invention can be used.

  The aqueous solvent used for extraction may be either water alone or an arbitrary mixed solution of water and one or two polar solvents such as methanol, lower alcohols such as ethanol, and acetone. However, since the active ingredient of the present invention cannot be extracted efficiently only with a polar solvent, it is desirable that the mixture is always mixed with water and the mixing ratio is 90% or less of the solvent. Among these solvents, it is preferable to use water, ethanol, or a mixture thereof from the viewpoint of safety, considering that the extract is finally mixed with food. The solvent used for extraction is water; alcohols such as methanol, ethanol, propanol and butanol; polyhydric alcohols such as propylene glycol and butylene glycol; ketones such as acetone and methyl ethyl ketone; esters such as methyl acetate and ethyl acetate; Linear and cyclic ethers such as hydrofuran and diethyl ether; hydrogen halides such as dichloromethane, chloroform and carbon tetrachloride; hydrocarbons such as hexane, cyclohexane and petroleum ether; aromatic hydrocarbons such as benzene and toluene; Polyethers such as polyethylene glycol; pyridines; soybean oil, rapeseed oil, squalane, isopropyl myristate, fats and oils such as palmitic acid, oleic acid, linoleic acid; supercritical carbon dioxide, etc. It can be used as a compound.

  The ratio of the newborn-derived component and the solvent at the time of extraction is not particularly limited, but the solvent is preferably 2-1000 times by weight with respect to the newborn-derived component 1, particularly 5-100 times by weight in terms of extraction operation and efficiency. . The extraction temperature is conveniently in the range of room temperature to the boiling point of the solvent under normal pressure, and the extraction time is preferably in the range of 10 minutes to 24 hours.

  In the present invention, the newborn extract is, for example, various solvent extracts obtained by extracting components derived from a newborn at room temperature or under heating or using an extraction device such as a Soxhlet extractor, and diluted solutions thereof. , Its concentrated solution or its dry powder. Here, the extract may be a mixture obtained from two or more newborns.

  The neonate-derived component aqueous solvent extract obtained as such, as it is, can be used in any state, such as a concentrated product, dried product obtained by removing the solvent from the eluate, From the viewpoint of safety of the organic solvent, it is preferable to use a dry product.

  The medicament of the present invention is prepared by formulating a neonatal-derived component extract as it is or with a known pharmaceutical carrier. The medicament of the present invention includes oral preparations such as tablets, granules, powders and syrups; parenteral preparations such as suppositories and external preparations, and foods such as beverages, milk, whey drinks and lactic acid bacteria drinks (particularly baby food) Etc.).

  The pharmaceutical carrier that can be used for the preparation of the medicament of the present invention is not particularly limited, and those that are usually used can be used. Examples thereof include starch, lactose, sucrose, mannitol, Solid carriers such as carboxymethyl cellulose, corn starch and inorganic salts; liquid carriers such as distilled water, physiological saline, aqueous glucose solution, ethanol and other alcohols, propylene glycol and polyethylene glycol; various animal and vegetable oils, white petrolatum, paraffin and waxes Oily carriers and the like.

  In addition, in order to produce foods, feeds, medicines and the like using the medicament of the present invention, appropriate components that are usually used can be blended depending on the type of the product. For example, when preparing food, glucose, fructose, sucrose, maltose, sorbitol, stevioside, rubusoside, corn syrup, lactose, citric acid, tartaric acid, malic acid, succinic acid, lactic acid, L-ascorbic acid, dl- α-tocopherol, sodium erythorbate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, gum arabic, carrageenan, casein, gelatin, pectin, agar, Vitamin Bs, nicotinic acid amide, calcium pantothenate, amino acids, calcium salts, pigments, fragrances, preservatives, etc., which are used as usual food ingredients can be blended as appropriate. .

When preparing infant medical supplies using the newborn-derived component extract of the present invention, other anti-inflammatory / anti-allergic cosmetic raw materials such as licorice extract components (for example, glycyrrhizic acid), diphenhydramine hydrochloride, azulene , Dl-α-tocopherol and its derivatives, vitamins B ₂ and B _6, etc., can enhance the effect.

  The composition of the present invention can be provided in any preparation form as long as the composition is suitable for transfer to an organism. Examples of such a pharmaceutical form include a liquid, an injection, and a sustained release agent. Examples of administration routes include oral administration, parenteral administration, and direct administration to the affected area.

  In the present specification, “instruction” describes the method for administering the pharmaceutical of the present invention to doctors, patients and other persons who administer it. This instruction describes a word for instructing administration of the medicine of the present invention. Further, the instruction sheet may include a word indicating an exposure method (for example, exposure at 37 ° C., cryopreservation method). This instruction is prepared in accordance with the format prescribed by the national supervisory authority (for example, the Ministry of Health, Labor and Welfare in Japan and the Food and Drug Administration (FDA) in the United States, etc. in the United States) where the present invention is implemented, and is approved by the supervisory authority. It is clearly stated that it has been received. The instruction sheet is a so-called package insert, and is usually provided as a paper medium, but is not limited thereto. But it can be provided.

  As used herein, “subject” refers to an organism to which the treatment of the present invention is applied, and is also referred to as a “patient”. The patient or subject may preferably be a human.

  The present invention can be provided in any formulation form. Examples of such a pharmaceutical form include a liquid, an injection, and a sustained release agent. Administration methods include oral administration, parenteral administration (for example, intravenous administration, intramuscular administration, subcutaneous administration, intradermal administration, mucosal administration, rectal administration, intravaginal administration, topical administration to affected areas, skin administration, etc.) Examples include direct administration to the affected area. Formulations for such administration can be provided in any dosage form. Examples of such a pharmaceutical form include a liquid, an injection, and a sustained release agent. The compositions and medicaments of the present invention may be in the form of an orally acceptable aqueous solution that is pyrogen-free when administered systemically. The preparation of such pharmaceutically acceptable protein solutions is within the skill of the artisan, provided that considerable attention is paid to pH, isotonicity, stability, and the like.

  The present invention, when formulated as a pharmaceutical or pharmaceutical composition, is optionally physiologically acceptable carriers, excipients or stabilizers (Remington's Pharmaceutical Sciences, 18th Edition, AR Gennaro, ed., Mack Publishing Company, 1990) and a selected composition having the desired degree of purity can be prepared for storage in the form of a lyophilized cake or an aqueous solution. The formulation procedure of the preparation of the present invention is known in the art, and is described in, for example, the Japanese Pharmacopeia, the US Pharmacopeia, the pharmacopoeia of other countries, and the like. The amount of the composition, medicine, etc. used in the method of the present invention is determined by a person skilled in the art in consideration of the purpose of use, the age, size, sex, medical history, composition, medicine, etc. Can be easily determined.

  The frequency with which the composition of the present invention is applied to an object can also be easily determined by those skilled in the art taking into consideration the purpose of use, the age, size, sex, medical history, treatment history, etc. of the object. . Examples of the frequency include administration once to several times a day, once every day to several months (for example, once a week to once a month). It is preferable to administer once a week to once a month while observing the course.

(screening)
Any screening method can be used for screening. For the screening, a system using an actual substance such as in vitro or in vivo may be used, or a library generated using an in silico (computer system) system may be used. Since it is known that the substance of the factor of the present invention exists in a newborn, it can be identified by using any purification method based on the activity, and the present invention can be identified based on the identified substance. Then, various screenings can be performed to identify substances having similar activities. In the present invention, it is understood that the compound obtained by the screening having the desired activity (that is, the stress reducing action) is also included in the scope of the present invention. The present invention also contemplates providing a computer modeling drug based on the disclosure of the present invention.

  In one embodiment, the present invention provides an assay for screening for components equivalent to the active ingredients of the present invention. Test compounds of the invention can be obtained using any of a number of approaches in combinatorial library methods known in the art, including: biological libraries; spatially Accessible parallel solid phase or solution phase library; synthetic library method requiring deconvolution; “one bead one compound” library method; and synthetic library method using affinity chromatography selection. The biological library approach is limited to peptide libraries, but the other four approaches are applicable to small molecule libraries of peptides, non-peptide oligomers or compounds.

  The screening method according to the present invention can be performed by methods well known to those skilled in the art, and international patent application WO 00/02045 performed by those skilled in the art on various solid supports such as microtiter plates or biochips according to known techniques. Preferably by high throughput screening, diagnostic and dosing devices based on the methods described in. The invention also relates to a molecule characterized by said method and optionally recovered, which is a sufficient amount of said molecule and pharmaceutically acceptable for the preparation of a medicament in the prevention and / or treatment of a particular disease. Pharmaceutical compositions comprising a suitable carrier or diluent.

(Exposure device design)
The present invention treats emotions related to postpartum depression, malaise, etc. by exposure to a subject (especially a woman, preferably a maternity blues woman) using a dedicated odor exposure device. can do.

(Use of the present invention)
The odor of the newborn acts positively on emotions related to postpartum women's depression, malaise, and so on. Therefore, it is thought that the smell of a newborn can be used for the following novel uses.
(1) From the above findings, it can be directly estimated that the smell of a newborn is effective for discomfort after childbirth. From the above, it is considered that the odor of a newborn can be used as “a composition for improving discomfort after childbirth”. These preferred embodiments are variously described herein.
(2) The effect of the smell of a newborn can be exerted not only in the form of a composition but also in the form of an instrument or a tool. Therefore, it is considered that the smell of a newborn can be used as “a tool for improving discomfort after childbirth”. These preferred embodiments are variously described herein.
(3) Since the odor of a newborn is effective in improving discomfort after childbirth, it can be used in the “method for improving discomfort after childbirth”. These preferred embodiments are variously described herein.

(Preferred embodiment)
Hereinafter, each application will be described.

(Composition for improving discomfort after childbirth (hereinafter sometimes referred to as “the composition for improving the present invention”))
The improving composition of the present invention contains a newborn odor as an active ingredient.

  The smell of the newborn to be used is not limited to one's own, but may be collected from another child.

  As used herein, `` discomfort after childbirth '' is a form of stress, and refers to symptoms such as depressed mood, anxiety, malaise, reduced motivation, insomnia / hypersomnia, loss of appetite, and binge eating. “Improving discomfort after childbirth” means improving at least one of the aforementioned symptoms. The unpleasant symptoms as described above appear in maternity blues. Therefore, the composition for improvement of the present invention has an effect of improving these symptoms.

(Tool for improving discomfort after childbirth (hereinafter sometimes referred to as “the tool for improving the present invention”))
The improvement tool of this invention has a part containing the smell of a newborn.

The odor of the newborn to be used takes various forms depending on the mode of use, but usually takes the same form as the fragrance treatment device described later.
(Aroma treatment composition)
The composition for treating aroma according to the present invention is prepared with various compositions according to its usage, and usually an underwear worn by a newborn for 8 to 24 hours is used. Generally, the aroma is inhaled as an aromatic bath using an aroma pot or a diffuser.

(Method for improving discomfort after childbirth (hereinafter sometimes referred to as “the method for improving the present invention”))
The improvement method of the present invention is characterized in that the smell of a newborn is administered to a person who exhibits discomfort after childbirth.

  As a method for administering the odor of a newborn, administration is performed by such a means that stimulation by the odor of the newborn is transmitted to the brain via the olfactory nerve. As an example of such administration means, a means for causing a person who exhibits unpleasant symptoms after delivery to smell the air containing the smell of a newborn can be exemplified.

(Fragrance)
The active ingredient of this invention can be used with a fragrance | flavor, and can use all the kinds of fragrance | flavors which can be used for a human and an animal, added to normal cosmetics or a chemical | medical agent. Examples of fragrances include lavender scent, lemon scent, floral scent, herb scent, apple scent, strawberry scent, lily scent, freesia scent, lilac scent, rose scent, acacia scent, There are Karin scent, musk scent, pheromone scent and pine scent, which can be used alone or in combination.

  The solvent for dissolving the active ingredient of the present invention is used for the purpose of effectively dissolving or dispersing each contained substance, and any solvent that is harmless to animals can be used. Preferred solvents are ethanol, isopropanol, or mixtures thereof, which can be included in the spray composition in residual amounts.

  As the filler used in the composition of the present invention, all the fillers used in spray products can be used. A typical filler is liquefied petroleum gas (LPG) for human bodies. Also, the filler may include a sufficient amount so that the antimicrobial composition of the present invention is applied in a spray form. A preferred content is 0.01 to 50% by weight.

  The composition of the present invention preferably has a pH of 3.0 to 9.0, more preferably 4.0 to 7.5. When the pH is lower than 3.0 or higher than 9.0, there may be dosage form stability and application side effects.

  The anti-composition of the present invention can be manufactured in liquid, gel, solid, aerosol form (AEROSOLS), or spray form (SPRAYS), depending on the dosage form, using ordinary substances well known to those skilled in the art. be able to. When the composition of the present invention is produced in a spray form, the composition can be produced in a powder injection type or a liquid injection type, preferably a liquid injection type.

  Such spray compositions can be sprayed into any environment. The spray composition can be used by filling a normal spray container. As an example, a plastic, aluminum, or tin container provided with a spray device can be mentioned.

  References such as scientific literature, patents and patent applications cited herein are hereby incorporated by reference in their entirety to the same extent as if each was specifically described.

  The present invention has been described with reference to the preferred embodiments for easy understanding. In the following, the present invention will be described based on examples, but the above description and the following examples are provided only for the purpose of illustration, not for the purpose of limiting the present invention. Accordingly, the scope of the present invention is not limited to the embodiments or examples specifically described in the present specification, but is limited only by the scope of the claims.

(Example 1: Effect on postpartum women)
We examined psychological changes that occurred when the scent of a newborn was smelled in postpartum (3-5 days) mentally and physically healthy women who were admitted to the Department of Obstetrics and Gynecology.

(1. Experimental method)
(1-1. Explanation and agreement)
This experiment was approved by the Nagasaki University School of Medicine Ethics Committee (approval number 17011489), and the subject was given a thorough explanation by the doctor about the contents of the experiment, and written consent was obtained. On the day of the experiment, foods and stimulants (garlic, onions, spices, herbs, etc.) with a strong smell were not eaten in the morning.

(1-2. Collection of newborn odors)
The odor of the newborn was collected from the subject's infant admitted to obstetrics or from another subject's infant. The smell of the newborn was collected before bathing the next day after the bathing of the newborn after bathing at 9:00 am. A 10 cm × 15 cm portion was cut out from the back of the collected underwear, and the underwear cloth was further divided into three equal parts and stored in a −80 ° C. freezer. In this experiment, this underwear cloth was used as the smell of a newborn baby, and when the experiment was carried out, it was packed in a 40 ml glass bottle and pre-warmed with a constant temperature bath of 37 ° C. for about 15 to 30 minutes. . Of the cloths divided into three equal parts, one was used for the subject's own experiment as “the smell of his / her newborn”, and the other two were used for the experiments of other subjects as “the smell of the newborn's newborn”. Moreover, the underwear for newborns that the newborn did not wear after washing was designated as “control”.

(1-3. Experiment day)
The subjects were allowed to smell the control (C: Control), the smell of another newborn (O: Other Infant Odor), and the smell of their own newborn (S :: Self Infant Odor) for 1 minute each time. went.

  Psychological examination is a revised version of VMS (Visual Analog) for 7 items of "happiness", "familiarity", "pleasantness", "anxiety", "motivation", "fatigue", and "maternity". Evaluation was performed using (Scale).

(2. Experimental results)
(2-1. Happiness)
FIG. 1 shows the test results of “happiness” when the scent of a newborn is smelled.

  As shown in FIG. 1, when sniffing “the smell of their own newborn”, subjects 3-5 days after giving birth gave a positive evaluation regarding “happiness”. Similarly, when they smelled “the smell of another person's newborn”, they gave a positive evaluation of “happiness”. It is considered that “the smell of one's newborn” and “the smell of another person's newborn” that make a subject feel “happiness” 3-5 days after giving birth are effective in improving the depressed mood after giving birth.

(2-2. Familiarity)
FIG. 2 shows the test result of “familiarity” in the case of smelling the newborn.

  As shown in FIG. 2, when sniffing “the smell of my newborn”, the subjects 3-5 days after giving birth gave a positive evaluation regarding “familiarity”. Similarly, when they smelled “the smell of another person's newborn”, they also gave a positive evaluation of “familiarity”. It is considered that “the smell of one's newborn” and “the smell of another person's newborn” that make the subject feel 3) 5 days after giving birth are effective in improving the depressed mood after giving birth.

(2-3. Pleasant)
FIG. 3 shows the test results for “comfort” when the scent of the newborn is smelled.

  As shown in FIG. 3, when sniffing “the smell of their own newborn”, the subjects 3-5 days after giving birth gave a positive evaluation regarding “pleasant”. It is considered that “the smell of one's newborn” that makes the subject 3-5 days after delivery feel “pleasant” is effective in improving the depressed mood after delivery.

(2-4. Anxiety)
The test result about "anxiety" when smelling the newborn baby is shown in FIG.

  As shown in FIG. 4, when sniffing “the smell of one's newborn”, subjects 3-5 days after giving birth gave a negative evaluation regarding “anxiety”. Similarly, when they smelled “the smell of another person's newborn”, negative evaluation was given regarding “anxiety”. It is considered that "the smell of one's newborn" and "the smell of another person's newborn" that reduce "anxiety" for a subject 3-5 days after delivery are effective in reducing anxiety after giving birth.

(2-5. Fatigue)
FIG. 5 shows the test results of “feeling of fatigue” when smelling the newborn.

  As shown in FIG. 5, when sniffing “the smell of my newborn”, the subjects 3-5 days after giving birth gave a negative evaluation regarding “feeling of fatigue”. Similarly, when they smelled “the smell of another person's newborn”, they also showed a negative evaluation of “fatigue”. It is considered that “the smell of one's newborn” and “the smell of another person's newborn” that reduce the “feeling of fatigue” for a subject 3-5 days after delivery are effective in reducing fatigue after giving birth.

(2-6. Motivation)
FIG. 6 shows the test result of “motivation” when the smell of the newborn is made to smell.

  As shown in FIG. 6, when sniffing “the smell of my newborn”, the subjects 3-5 days after giving birth gave a positive evaluation regarding “motivation”. It is thought that “the smell of one's newborn” that makes the subject 3-5 days after giving birth feel “motivated” is effective in improving the decreased motivation after giving birth.

(2-7. Maternity)
FIG. 7 shows the test results for “maternality” when the scent of a newborn is smelled.

  As shown in FIG. 7, when sniffing “the smell of my newborn”, the subjects 3-5 days after giving birth gave a positive evaluation regarding “maternity”. Similarly, when they smelled “the smell of another person's newborn”, they gave a positive evaluation of “maternity”. It is considered that “the smell of one's newborn” and “the smell of another person's newborn”, which increase “maternity” for a subject 3-5 days after delivery, are effective for increasing the motherhood after delivery.

(Example 2: Effect on women other than postpartum)
In this example, women who have not experienced childbirth (10s, 20s, 30s) and parous women (20s, 30s, 40s, 50s) in place of the women targeted in Example 1 A similar experiment was conducted on the subject.

  A female who had not experienced parturition in the twenties (i.e., heifer) (n = 12 Mean age 25.8 y) was used as a test subject. The subject conducted the experiment using the same protocol as the mother immediately after delivery. Also, since the baby's smell cannot be distinguished from others, the baby's smell was used. The odor of the baby was divided into odors collected from the body and those collected from the head (back of the head). The female test subjects were asked about the menstrual cycle up to 3 months before to determine whether the day of the experiment was before ovulation (follicular phase: F) or after ovulation (luteal phase: L). As a result, all the subjects were collected without considering the menstrual cycle (n = 12), the woman in the follicular phase (n = 7), and the woman in the luteal phase (n = 5).

(result)
In FIGS. 8 to 28, experiments conducted on newborns with respect to nulliparous (all), nulliparous (F), and nulliparous (L) are shown as “happiness”, “friendly”, “pleasant”, “ The results of investigating the smell of the control and the body and the head for anxiety, fatigue, motivation and motherhood are shown.

  For newborns, the scent of the baby's body tended to be positive in all of the babies (all), babies (F) and babies (L). In addition, there was a tendency that the odor of the baby's body acted more positively in the follicular phase than in the luteal phase.

(Example 3: Effect of various neonatal ingredients)
In this example, how the effect varies depending on the type of other newborn (1 day, 2 days, 1 week, 1 month, 2 months) or a premature baby instead of the newborn used in Example 1. Find out.

  As an example, a premature baby and a newborn can be compared. In this embodiment, in this case, the subject mother can be a person who has passed about one month after giving birth.

  The protocol according to Example 1 can be used.

(result)
For premature infant mothers, control happiness, friendliness, pleasure, anxiety, fatigue, motivation, and maternity, and examine the body and head odors of premature infants. It can be understood that the result is the same as that of a newborn.

(Example 4: Identification and purification method)
The active ingredient of the present invention can be identified and purified as follows.

  Male in 1986, 1987 by George Pretty, Cutler et al. (Preti G Horm Behav. 1986 Dec; 20 (4): 474-82; Cutler WB Horm Behav. 1986 Dec; 20 (4): 463-73) The method of extracting the odorous substance is referred to. Two pieces of 10 cm × 10 cm cloth are cut out from the underwear worn by the newborn (8h-24h) or the portion of the underwear not worn by the newborn (control). 15 ml of ethanol is added to the two sheets and left at room temperature for 1 hour in a moist state. After 1 hour, the cloth is squeezed with a hand wearing rubber gloves, and ethanol containing components adhering to the underwear of the newborn is extracted. The yield is about 2/3, about 10 ml.

  Take 2 ml from the extracted solution, put it in another bottle, add 2 ml of MilliQ water to make 4 ml of 50% ethanol. This 4 ml is allowed to stand at room temperature overnight, and the ethanol component is volatilized as much as possible. As the solvent, those used as perfume solvents such as propylene glycol and dipropylene glycol can also be used.

  After one night (extraction work is performed the day before the experiment), 1.5 ml is taken from the extract, put on absorbent cotton, and the absorbent cotton is placed in the bottle used in Example 1 and the same is applied to the mother. The experiment was conducted.

(result)
As a result of the extraction experiment (n = 5), the solution in which the smell of the newborn was extracted tended to be more positive than the control (FIGS. 36 to 42). The results will be described below.

  As shown in FIG. 29, when the “newborn odor extraction solution” was made to smell, subjects 3-5 days after giving birth gave a positive evaluation regarding “happiness”. It is considered that a “newborn odor extraction solution” that makes a subject 3-5 days after giving birth feel “happiness” is effective in improving depressed mood after delivery.

  As shown in FIG. 30, when the “newborn odor extraction solution” was sniffed, the subjects 3 to 5 days after giving birth gave a positive evaluation regarding “familiarity”. It is considered that a “newborn odor extraction solution” that makes the subject feel 3) 5 days after giving birth is effective in improving the depressed mood after giving birth.

  As shown in FIG. 31, when sniffing the “newborn odor extraction solution”, the subjects 3-5 days after giving birth gave a positive evaluation regarding “pleasant”. It is considered that a “newborn odor extraction solution” that makes a subject feel “pleasant” 3-5 days after childbirth is effective in improving depressed mood after childbirth.

  As shown in FIG. 32, when the “newborn odor extraction solution” was sniffed, the subjects 3-5 days after giving birth gave a negative evaluation regarding “anxiety”. A “newborn odor extraction solution” that reduces “anxiety” for subjects 3-5 days after delivery is considered effective in reducing anxiety after childbirth.

  As shown in FIG. 33, when the “newborn odor extraction solution” was sniffed, the subjects 3-5 days after giving birth gave a negative evaluation regarding “feeling of fatigue”. It is considered that a “newborn odor extraction solution” that reduces “feeling of fatigue” for subjects 3 to 5 days after delivery is effective in reducing fatigue after delivery.

  As shown in FIG. 34, when the “newborn odor extraction solution” was sniffed, the subjects 3-5 days after giving birth gave a positive evaluation regarding “motivation”. The “newborn odor extraction solution” that makes the subject 3-5 days after giving birth feel “motivated” is considered to be effective in improving the reduced motivation after delivery.

  As shown in FIG. 35, when the “newborn odor extraction solution” was sniffed, the subjects 3-5 days after giving birth gave a positive evaluation regarding “maternity”. It is considered that a “newborn odor extraction solution” that makes a subject 3-5 days after giving birth feel “maternity” is effective for increasing maternity after delivery.

  Therefore, it has been clarified that the extraction method of the present invention can be used for purifying and separating active ingredients while maintaining the stress reduction effect of the present invention.

(Example 5: Storage effect)
The preservation effect of the active ingredient of the present invention is examined.

  In addition to the method described in Example 1, the cryopreservation method confirms the effect of the preservation method of no storage, -80 ° C., and quick freezing (−30 ° C. or lower) with dry ice.

  As a comparison experiment, the experiment is performed in the case where the milk is not frozen and stored refrigerated (4 ° C.) and left at room temperature (RT).

(result)
Storage of odorous substances is desirable at −80 ° C., but it may be possible at −30 ° C. or lower.

(Example 6: Formulation)
Next, the stress relieving agent of the present invention is formulated.

  Similar to the natural aromatherapy fragrance, it is extracted with alcohol as a natural ingredient derived from a newborn, mixed with a solvent such as propylene glycol, and formulated in the form of an essential oil.

(Example 7)
A subject 1 to 2 days after giving birth entered a test room (6-8 tatami mats) and asked to answer the Japanese version of the STAI questionnaire. Then, after the subject was exposed to the test substance for 1 hour, he was asked to answer the Japanese version of the STAI questionnaire as described above. The STAI questionnaire was made by Sankyobo and examined for two types of anxiety: state anxiety and characteristic anxiety. Exposure to the test substance was performed by filling the room with the test substance with a commercially available aromatherapy diffuser (tree of life). As the test substance, the active ingredient of the present invention is used, and as a control, Clarisage (NEAL'S YARD REMEDIAS) and Sandalwood (NEAL'S YARD REMEDIAS), which are considered effective against anxiety, are used. It was.

  STAI scores for state anxiety and characteristic anxiety before and after exposure can be determined.

  In addition, the effect on the state anxiety and characteristic anxiety of the test substance is “highly effective (STAI score decrease value before and after exposure is 10 or more)”, “effective (STAI score decrease value before and after exposure is 4 or more and less than 10)”, It is classified into three types of “invalid (reduced value of STAI score before and after exposure is less than 4)”, and it is examined to which of the effects each subject belongs.

  As a result, it can be seen that the active ingredient of the present invention is effective for state anxiety and characteristic anxiety.

  As mentioned above, although this invention has been illustrated using preferable embodiment of this invention, it is understood that the scope of this invention should be construed only by the claims. Patents, patent applications, and documents cited herein should be incorporated by reference in their entirety, as if the contents themselves were specifically described herein. Understood.

  The present invention provides ingredients that are particularly effective as stress relieving agents for postpartum women. It has been clarified in the present invention that such a component is effective if it is a component derived from a newborn, regardless of the system, even if it is derived from a newborn derived from the same species. Therefore, this invention is useful in the industry etc. which manufacture an anti-stress formulation.

It is a figure which shows the test result about "happiness" when a subject smells the newborn. It is a figure which shows the test result about "familiarity" when making a test subject smell of a newborn. It is a figure which shows the test result about "pleasantness" when making a test subject smell of a newborn. It is a figure which shows the test result about "anxiety" when making a test subject smell of a newborn. It is a figure which shows the test | inspection result about "fatigue" at the time of making a test subject smell the newborn. It is a figure which shows the test result about "motivation" when making a test subject smell of a newborn. It is a figure which shows the test | inspection result about "maternity" at the time of making a test subject smell the newborn. It is a figure which shows the test | inspection result about "happiness" in the case where the test subject (the heifer (all)) is made to smell the newborn. It is a figure which shows the test result about "familiarity" at the time of making a test subject (the heifer (all)) smell the newborn. It is a figure which shows the test | inspection result about "pleasantness" when making a test subject (childbirth (all)) smell the newborn. It is a figure which shows the test | inspection result about "anxiety" at the time of making a test subject (childbirth (all)) smell the newborn. It is a figure which shows the test result about "fatigue" at the time of making a test subject (childbirth (all)) smell the newborn. It is a figure which shows the test result about "motivation" at the time of making a test subject (childbirth (all)) smell the newborn. It is a figure which shows the test | inspection result about "maternality" when making a test subject (the heifer (all)) smell the newborn. It is a figure which shows the test result about "happiness" when making a test subject (childbirth (F)) smell a newborn. It is a figure which shows the test | inspection result about "familiarity" when making a test subject (childbirth (F)) smell the newborn. It is a figure which shows the test | inspection result about "pleasantness" when making a test subject (childbirth (F)) smell a newborn. It is a figure which shows the test result about "anxiety" at the time of making a test subject (childbirth (F)) smell a newborn. It is a figure which shows the test result about "feeling of fatigue" at the time of making a test subject (childbirth (F)) smell a newborn. It is a figure which shows the test result about "motivation" at the time of making a test subject (childbirth (F)) smell the newborn. It is a figure which shows the test | inspection result about "maternality" when making a test subject (childbirth (F)) smell the newborn. It is a figure which shows the test result about "happiness" when a test subject (childbirth (L)) is made to smell the newborn. It is a figure which shows the test result about "familiarity" at the time of making a test subject (childbirth (L)) smell the newborn. It is a figure which shows the test | inspection result about "pleasantness" when making a test subject (childbirth (L)) smell a newborn. It is a figure which shows the test result about "anxiety" at the time of making a test subject (childbirth (L)) smell the newborn. It is a figure which shows the test result about "feeling of fatigue" at the time of making a test subject (childbirth (L)) smell the newborn. It is a figure which shows the test result about "motivation" at the time of making a test subject (childbirth (L)) smell a newborn. It is a figure which shows the test | inspection result about "maternity" when making a test subject (childbirth (L)) smell the newborn. In FIG. 29, the result of having tested the result of extraction experiment about "happiness" is shown. As shown in FIG. 36, when the “newborn odor extraction solution” was sniffed, the subjects 3-5 days after giving birth gave a positive evaluation regarding “happiness”. It is considered that a “newborn odor extraction solution” that makes a subject 3-5 days after giving birth feel “happiness” is effective in improving depressed mood after delivery. FIG. 30 shows a result of testing the result of the extraction experiment for “familiarity”. As shown in FIG. 37, when the “newborn odor extraction solution” was sniffed, the subjects 3-5 days after giving birth gave a positive evaluation regarding “familiarity”. It is considered that a “newborn odor extraction solution” that makes the subject feel 3) 5 days after giving birth is effective in improving the depressed mood after giving birth. In FIG. 31, the result of having tested the result of extraction experiment about "pleasant" is shown. As shown in FIG. 38, when the “newborn odor extraction solution” was sniffed, the subjects 3-5 days after giving birth gave a positive evaluation regarding “pleasant”. It is considered that the “newborn odor extraction solution” that makes the subject 3-5 days after delivery feel “pleasant” is effective in improving the depressed mood after childbirth. In FIG. 32, the result of having tested the result of extraction experiment about "anxiety" is shown. As shown in FIG. 39, when the “newborn odor extraction solution” was sniffed, the subjects 3-5 days after giving birth gave a negative evaluation regarding “anxiety”. A “newborn odor extraction solution” that reduces “anxiety” for subjects 3-5 days after delivery is considered effective in reducing anxiety after delivery. In FIG. 33, the result of having tested the result of extraction experiment about "feeling of fatigue" is shown. As shown in FIG. 40, when the “newborn odor extraction solution” was sniffed, the subjects 3-5 days after giving birth gave a negative evaluation regarding “fatigue”. It is considered that a “newborn odor extraction solution” that reduces the “feeling of fatigue” for subjects 3-5 days after delivery is effective in reducing fatigue after delivery. In FIG. 34, the result of having tested the result of extraction experiment about "motivation" is shown. As shown in FIG. 41, when the “newborn odor extraction solution” was sniffed, the subjects 3-5 days after giving birth gave a positive evaluation regarding “motivation”. The “newborn odor extraction solution” that makes the subject 3-5 days after giving birth feel “motivated” is considered to be effective in improving the reduced motivation after delivery. FIG. 35 shows a result of testing the result of the extraction experiment for “maternity”. As shown in FIG. 42, when the “newborn odor extraction solution” was sniffed, the subjects 3-5 days after giving birth gave a positive evaluation regarding “maternity”. It is considered that a “newborn odor extraction solution” that makes a subject 3-5 days after giving birth feel “maternity” is effective for increasing maternity after delivery.

Claims (33)

  A composition for improving stress, comprising a component derived from a newborn.   The composition according to claim 1, wherein the component is an odor component. The composition of claim 1, wherein the stress is female stress.   The composition of claim 1, wherein the stress is after female birth.   The composition according to claim 1, wherein the stress is a discomfort after delivery of a woman.   The composition of claim 1, wherein the ingredient is derived from the sweat of the newborn.   The composition according to claim 1, wherein the newborn is one month old or less.   The composition according to claim 1, wherein the newborn is within one week of birth.   The composition according to claim 1, wherein the component is recovered from the underwear after the newborn is put on the underwear and continued to be worn for 8 to 24 hours. The composition according to claim 1, wherein the stress is measured by a psychological test item selected from the group consisting of happiness, familiarity, pleasure, anxiety, motivation, fatigue, and motherhood. The composition according to claim 1, wherein the stress is measured by a psychological test item selected from the group consisting of happiness, familiarity, anxiety, fatigue, and motherhood. The composition according to claim 1, wherein the stress is measured by a psychological test item selected from the group consisting of pleasure and motivation, and the newborn is the female child. The composition of claim 1, wherein the stress is due to maternity blues.   A method for stress improvement comprising the step of administering a component derived from a newborn.   The method of claim 14, wherein the component is an odor component. 15. The method of claim 14, wherein the stress is female stress.   15. The method of claim 14, wherein the stress is after childbirth.   15. The method of claim 14, wherein the stress is a discomfort after childbirth.   15. The method of claim 14, further comprising extracting a component derived from neonatal sweat as the component.   15. The method of claim 14, wherein the newborn is less than one month old.   15. The method of claim 14, wherein the newborn is within one week of birth.   15. The method of claim 14, further comprising the step of recovering the component from the underwear after the newborn has been put on the underwear and continued to be worn for 8 to 24 hours. The method of claim 14, wherein the stress is measured by a psychological test item selected from the group consisting of happiness, friendliness, pleasure, anxiety, motivation, fatigue, and maternity. The method according to claim 14, wherein the stress is measured by a psychological test item selected from the group consisting of happiness, familiarity, anxiety, fatigue, and maternity. 15. The method according to claim 14, wherein the stress is measured by a psychological test item selected from the group consisting of pleasure and motivation, and the newborn is the female child. 15. The method of claim 14, wherein the stress is due to maternity blues. An apparatus for stress improvement comprising a part containing a component derived from a newborn. 28. The device of claim 27, wherein the component has the features of any one of claims 2-13. 28. The apparatus of claim 27, wherein the means for administering the neonatal odor is a means by which stimulation by the neonatal odor is transmitted to the brain via the olfactory nerve. 28. The apparatus according to claim 27, wherein the means by which stimulation by the smell of the newborn is transmitted to the brain via the olfactory nerve is means for causing the subject to smell the air containing the smell of the newborn. 31. The apparatus according to any one of claims 27 to 30, wherein the stress is a discomfort after childbirth. 31. The apparatus according to any one of claims 27 to 30, wherein the stress is due to maternity blues, which is a discomfort after childbirth. Use of a component derived from a newborn in the manufacture of a medicament for improving stress.

Images