JP2007070291A - Sunscreen external lotion - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new sunscreen external lotion having an excellent sun-screening effect. <P>SOLUTION: This sun screen external agent is obtained by finding an effect of powerfully inhibiting erythema formation caused by ultraviolet light by leaps and bound by the combined use of 1 kind or ≥2 kinds selected from a substance showing physiologically antioxidation effect such as vitamin C, its derivatives and salts, vitamin Es, their derivatives and salts, dibutylhydroxytoluene and butylhydroxyanisole, or 1 kind or ≥2 kinds selected from a cinnamic acid-based ultraviolet light-absorbing agent, a benzophenone-based ultraviolet light absorbing agent, a benzoic acid-based ultraviolet light absorbing agent, a salicylic acid-based ultraviolet light-absorbing agent, a dibenzoylmethane-based ultraviolet light-absorbing agent, an anthranilic acid-based ultraviolet light-absorbing agent, an urocanic acid-based ultraviolet light-absorbing agent and an ultraviolet light-scattering agent with a basil (Ocimum basilicum) extract. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

The present invention relates to an external preparation for skin, such as cosmetics and external medicines, which have an excellent sun protection effect by containing a basil extract as a sunscreen in combination with an antioxidant or an ultraviolet protective agent.

So far, sunscreen cosmetics have been mainly prevented from sunburn by blending UV absorbers or UV scattering agents. However, many of the ultraviolet absorbers have skin irritation, and the blending amount thereof is limited. Many of the ultraviolet light scattering agents are white pigments. If they are added too much, the makeup becomes too thick, whitish, etc., so that the amount of addition is limited to some extent. Therefore, a method for preventing sunburn by a method different from ultraviolet absorption or ultraviolet scattering has been demanded.

Regarding basil or Shiso family plants, reports on their antioxidant action (Non-Patent Document 1-3) and patents as active oxygen inhibitors (Patent Document 1) or whitening (Patent Document 2-3), atopic There are things related to dermatitis treatment / prevention (Patent Document 4), deodorization (Patent Document 5-6), anti-aging preventive (Patent Document 7), etc. There is no report on those having an effective ingredient, particularly those that have obtained a great effect by the combined use with an antioxidant or an ultraviolet absorber.
Jayasinghe C, Gotoh N, Wada S: J Agric FoodChem. 51 (15): 4442-4449, 2003 Yun Ys, Nakajima Y, Iseda E, Kunugi A: Shokuhin Eiseigaku Zasshi 44 (1): 59-62, 2003 Lee KG, Shibamoto T: J Agric Food Chem. 50 (17): 4947-4952, 2002 JP-A-8-11869 JP-A-9-77636 JP 2000-119156 A JP-A-9-118629 JP-A-2004-123684 JP 2002-255774 A JP 2002-104924

Therefore, it is a problem to provide a skin external preparation having a synergistically excellent sun protection effect by containing a substance having an effect of preventing sunburn due to ultraviolet rays, which is different from an ultraviolet absorber and an ultraviolet scattering agent. It was.

Focusing on the mechanism that ultraviolet erythema is formed through the generation of reactive oxygen species, we screened for substances that prevent ultraviolet rays from causing erythema on the skin. As a result, in addition to vitamin C, which exhibits physiological antioxidant activity, the basil extract was found to have an effect of strongly suppressing erythema formation due to ultraviolet rays. Furthermore, the present inventors have found that the basil extract exhibits a greater effect when used in combination with an antioxidant such as vitamin C or an ultraviolet protective agent, and thus completed the present invention.

A more excellent external preparation for skin can be provided by blending a basil extract together with an antioxidant. In addition, because of the high safety of basil extract, it can be used in combination with highly safe antioxidants such as vitamin C, and can provide a skin external preparation that is safe even when applied directly to the skin. .

A more excellent external preparation for skin can be provided by blending a basil extract together with a UV protection agent. Further, by blending the basil extract together, the same amount of sunscreen prevention effect can be obtained with an ultraviolet absorber having a smaller blending amount than before, and a safer skin external preparation can be provided.

The basil extract that can be used in the present invention is obtained by extracting a whole plant of Labiatae genus basil (Ocimum basilicum) with a solvent such as water. There are no particular restrictions. Moreover, if the antioxidant and ultraviolet absorber used together are also marketed, there will be no restriction | limiting in particular.

The content of the basil extract in the present invention is preferably in the range of 0.5% to 10%. The content of vitamin antioxidants such as vitamin C and derivatives thereof and salts thereof, vitamin Es and derivatives thereof and salts thereof is preferably in the range of 0.5% to 5%, and synthetic antioxidants For example, the content of dibutylhydroxytoluene and butylhydroxyanisole is preferably in the range of 0.5% to 2%.

Cinnamic acid UV absorbers such as paramethoxycinnamic acid-2-ethylhexyl, isopropyl paramethoxycinnamic acid, paramethoxyhydrocinnamic acid diethanolamine, diparamethoxycinnamic acid-glyceryl mono-2-ethylhexanoate The content of octyl methoxycinnamate is preferably in the range of 0.5% to 10%, and the content of benzophenone-based ultraviolet absorbers such as 2-hydroxy-4-methoxybenzophenone and 2,4-dihydroxybenzophenone is preferred. Is in the range of 0.5% to 5%, the content of benzoic acid UV absorber, paraaminobenzoic acid, paraaminobenzoic acid ester, glyceryl paraaminobenzoate is preferably in the range of 0.5% to 5%, salicylic acid type UV absorbers, such as methyl salicylate, 2-ethylhexyl salicylate, dipropylene glycol salicylate The content of ruthenium, amyl salicylate, and benzyl salicylate is preferably in the range of 0.5% to 10%, and the content of dibenzoylmethane-based UV absorbers, such as 4-t-butyl-4'-methoxybenzoylmethane, Preferably, it is in the range of 0.5% to 5%, and the content of anthranilic acid-based UV absorbers such as menthyl-o-aminobenzoate, 3-diphenyl acrylate, menthyl anthranilate is preferably in the range of 0.5% to 5%. is there. The content of the ultraviolet scattering agent such as titanium oxide, zinc oxide, cerium oxide or zirconium oxide is preferably in the range of 1% to 30%. When a basil extract and an antioxidant or UV protection agent are combined in these ranges, a more excellent synergistic sun protection effect can be obtained. Moreover, each content is in the said range, and if it is combined use with a basil extract, the combination of another antioxidant or a ultraviolet protective agent will not be limited.

EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated concretely, this invention is not limited to an Example at all.

Labiatae (Ocimum)
Basilicum) was dried, and 200 g of the whole plant was soaked in 2 liters of water at 60 ° C. for 4 hours and filtered to obtain a basil water extract.

(Test example)
Creams were prepared according to the formulation shown in Table 1, and the sun protection effect was examined by the following method.

A water-soluble component and purified water were mixed to form an aqueous phase. An oil-soluble component was mixed to obtain an oil phase. Both the aqueous phase and the oil phase were dissolved by heating to 80 ° C., and the oil phase was slowly added to the aqueous phase with stirring to emulsify, and the mixture was cooled to 37 ° C. with stirring to obtain a cream.

(Test method)
The sun protection effect was evaluated by measuring the minimum ultraviolet dose (MED) required for erythema formation in Hartley guinea pigs and measuring the ability to increase MED. UV irradiation device (Dermaray on shaved back abdomen
MED was measured by irradiating with UV light using M-DMR 50, UV lamp [Toshiba FL20S.E-30 / DMR, 7 lights], Toshiba medical supplies) and observing the presence or absence of erythema at each irradiation time. UV intensity meter (UVR-305 / 365,
The intensity of irradiation was 2.080 mW / cm ² and the irradiation energy for 1 minute was 1.25 × 10 ⁶ erg / cm ² / min. Each cream was applied 30 minutes before UV irradiation.

(Results) The results are shown in Table 2.

When the cream was not applied, the MED was 5.41 × 10 ⁶ erg / cm ² , and the MED was slightly extended by applying the cream (Comparative Example 1).

The MED of Comparative Example 2 was larger than that of Comparative Example 1, and the cream containing the basil water extract extended the MED.

The cream containing vitamin C and vitamin E (Comparative Example 3) has a longer MED than the cream application (Comparative Example 1).

In addition, the cream (Example 1) to which the basil aqueous extract was added prolongs the MED dramatically. On the other hand, no further extension was observed in the cream added with indomethacin (Comparative Example 4).

A cream containing 2-methoxyhexyl paramethoxycinnamate (Comparative Example 5) extended the MED.

The cream (Example 2) obtained by further adding the basil water extract to Comparative Example 5 greatly extended the MED.

As described above, the cream containing the basil water extract was found to have an effect of suppressing erythema formation due to ultraviolet rays. In addition, vitamin C and vitamin E, which are antioxidants, and 2-ethylhexyl paramethoxycinnamate, which is an ultraviolet absorber, were also found to suppress the formation of erythema due to ultraviolet rays. In addition, creams containing basil water extract in combination with vitamin C and vitamin E were found to synergistically increase the effect of suppressing erythema formation due to ultraviolet rays. However, the cream containing indomethacin in combination with vitamin C and vitamin E did not increase the effect of suppressing erythema formation due to ultraviolet rays. This suggests that the basil water extract acts specifically when combined with vitamin C and vitamin E, and synergistically suppresses erythema formation due to ultraviolet rays.

Since the sunscreen skin external preparation of the present invention is excellent in skin safety and has a high sunscreen effect, it can be widely applied to sunscreen cosmetics and the like.

Claims (3)

A skin external preparation characterized by containing a basil extract and an antioxidant or a UV protection agent. The antioxidant is one or more selected from vitamin C and derivatives thereof and salts thereof, vitamin E and derivatives thereof and salts thereof, dibutylhydroxytoluene and butylhydroxyanisole. The external preparation for skin according to 1. UV protective agent is cinnamic acid UV absorber, benzophenone UV absorber, benzoic acid UV absorber, salicylic acid UV absorber, dibenzoylmethane UV absorber, anthranilic acid UV absorber, urocanic acid UV 2. The skin external preparation according to claim 1, wherein the external preparation is one or more selected from an absorbent and an ultraviolet scattering agent.